miRTarBase - #MIRT611153


—
pre-miRNA Information
pre-miRNA hsa-mir-4254   
Genomic Coordinates chr1: 31758660 - 31758735
Description Homo sapiens miR-4254 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4254
Sequence 44| GCCUGGAGCUACUCCACCAUCUC |66
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1415016281 1 dbSNP
rs564274475 8 dbSNP
rs12731294 9 dbSNP
rs780735773 13 dbSNP
rs1207241221 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF486   
Synonyms KRBO2
Description zinc finger protein 486
Transcript NM_052852   
Expression
Putative miRNA Targets on ZNF486
3'UTR of ZNF486
(miRNA target sites are highlighted)		 
>ZNF486|NM_052852|3'UTR
   1 CAAAGGATTATTTTATTATTATTATTTTTTTGAGAGGTAATTCTGCTGTTGTTTCCCAGGCTGGAGTGCAATGGCATAAT
  81 TTTGGCTCACCACAACCTCCACCTTCTGGGTTCAAGTAACTCTCCTTAGTAGCTAGGATTACAGGGCTGCACCACCACAC
 161 CTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAATCTCCTAACCTCAGGTGG
 241 TCTGCCTGCTTTGGCCTCCCAAAGTGTTGGGGTTACAGGCATGAGCCACTGTGCCTGGCTGACAAAGCTTTTTAAGGAAG
 321 TTCTCAACCCTTATTACACATAATTCATACTGGACAGAAACCCTACAAGTGTGAAGAATGTGGCAAGCCTGTAACAAGTT
 401 CTCAATTCTTTTATTTTTATTTGTTTATTTATTTTTTGAGATGCAGTTTCACTCTTGTGACCCGGGCTGTAGTGCAATGG
 481 CATGATCTTGGCTTACTGTGACCTCTGCCTCCTGGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTA
 561 CAGGTGCCACCACCATTCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGCTTTTGCCATATTTGCCAGGCTGGTCTCA
 641 AACTCCTGACCTCAGGTGATCCACTCGCCTCGGCTTCCTAAAGTGCTGGGATGACAGGCATGAGCCTCAATTCCCAGCCA
 721 TAAGCTCTTAATTCTTAAGAGACATGGCGATAATTCATGGTGAAGAGGAACTTTACAAACCTGAAAGATGTGACAGTGCT
 801 TTTCCCAACACCTCCAACTTTTCTATGCATAAAAAAAATTATACTACACCATAGAAATGTATGAAATGTGACAAAGCCTT
 881 TATATGGTTGCCACACTTTATTGTAGGTAATTCATACTTCCAAAATACCTACAAGTATGAAGAATGTGGCAAAACTTTTA
 961 ATCAGTGCTTACACCGTATTTCACAGGAAAGCTATTATCCTTGAGAAAAATTGTACAAATATAAAGAATATGGAAAAGCC
1041 ATTAATGTCCATCACATCTTACTCAACAGAAGAAGGTTCATAAAAGAGCAATTACTGTGACAAAAATCTTTCAGAAAATA
1121 TAAGCCTTTAAGGTGAAGAAGAGTATTGATTCTGAAGACAAGCATTACAAATATAAAGAGGTTTGTAGTACCTTTGCTTG
1201 TATTACAGATCTTATTGCCCGCGTTTTGTATTAGAAGGAAACCCTAAAGCGGTTGCCAAACTTTGTGCAACATCAGGGAA
1281 TGTATATTGAAGAAGATTCCTGCAAATGTAATGAGTTTGGAAACACTTCTTAGATAAATTATTTGTGGCTGGGCACAGTG
1361 GCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATCACCTGATGTCGGGAGTTTGAGATCAGACTGAC
1441 CAAAACGGAGAAACCCAGTCTCTACTGAAAATATAAAATTAGCCATGCATGGTGGCACATGCCTGTAATCCCAGCTACTC
1521 AGGAGGCTTGAACCCTGGAGGCAGAGGTTGTGGTGAGTCGAGATCATTGCACTCCAGCCTGGGCAATAAGAGTGAAACTC
1601 TGTCTCCAGGAAAAAAAAAAATTTATTTGTGTATAACTTTAAAAGCAGATTTTTGGAAGCATTGTAATTACATTAAAAGT
1681 ATACTTGTTCCAGCTGCGTGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACGAGGT
1761 CAGGAGTTCAAGACCATCTTGGCCAAGATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCCATGCATGGTGGC
1841 CGGCGCGTATAATCCCAGCTGCTTGGGAGGCTGAGGCAGAGAATTGGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGT
1921 GAGCCGAGGTTGCACCATTGTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAGTGTATTTGTTTCCTTA
2001 AAAAAATTTTTCTGAAAAGTGGGTAATGACATAATACAGCTTTCAAATTACTTTATGCTGTTATTTTATTCTTATTGTAT
2081 TCACATGTGAAAGCATGTGATCAATTTTTGCTGCATCAGAGATATTAGAGATAGTTTTTTATTAATTGGGCATTTATGAC
2161 CTTTTCTATAAAAGTAAGGACATTAAAATGTAAGATGCATGATGAAAATATAAGTGGAGAGGCTCTTTGTAGTTAACCTA
2241 TATGAAGTAATGTATAAGGTAGGTCAGAGTAATACTTTTCTACATTATAGTGCAAGAAATAATTATTGATAAAAGTATAT
2321 TAAACTAAATTCGTATATTTTACTTATTGTACTTTTATGTAATAAAATGCAGTGCATTTAAAAATTGT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cucuacCACCU---CAUCGAGGUCCg 5'
                ||| |    |: ||||||| 
Target 5' ataagaGTGAAACTCTGTCTCCAGGa 3'
 1586 - 1611 145.00 -16.60
2 
miRNA  3' cuCUAC-CACCUC----AUC--GAGGUCcg 5'
            |:|| || |||    | |  ||||||  
Target 5' gtGGTGAGTCGAGATCATTGCACTCCAGcc 3'
 1550 - 1579 133.00 -18.10
3 
miRNA  3' cuCUACCACCUCAUCGAGGUCCg 5'
            || | |||:||  ||||| | 
Target 5' taGA-GATGGGGTTTCTCCATGt 3'
 183 - 204 132.00 -19.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN19767104 28 COSMIC
COSN18742119 32 COSMIC
COSN30142030 43 COSMIC
COSN20302860 93 COSMIC
COSN4966679 120 COSMIC
COSM6437266 353 COSMIC
COSN21744751 466 COSMIC
COSN26868777 467 COSMIC
COSN30690959 494 COSMIC
COSN6139358 749 COSMIC
COSN28446515 1039 COSMIC
COSN8552233 1209 COSMIC
COSN16698229 1250 COSMIC
COSN17845758 1623 COSMIC
COSN6139359 2162 COSMIC
COSN1762172 2294 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs782647320 2 dbSNP
rs782268139 4 dbSNP
rs782410234 10 dbSNP
rs1200942318 13 dbSNP
rs1466939946 13 dbSNP
rs782042728 16 dbSNP
rs1209536239 19 dbSNP
rs991735472 21 dbSNP
rs146746753 22 dbSNP
rs532476856 25 dbSNP
rs751270209 25 dbSNP
rs375278545 26 dbSNP
rs782101742 28 dbSNP
rs111401072 30 dbSNP
rs929292486 35 dbSNP
rs782619728 38 dbSNP
rs1370636976 39 dbSNP
rs1321708705 42 dbSNP
rs1435354243 43 dbSNP
rs112134607 44 dbSNP
rs1399562997 47 dbSNP
rs890545660 49 dbSNP
rs749525641 52 dbSNP
rs1425299662 60 dbSNP
rs1007601131 70 dbSNP
rs1175364457 72 dbSNP
rs1452519446 76 dbSNP
rs1039627676 81 dbSNP
rs11667300 85 dbSNP
rs1466400653 88 dbSNP
rs181479393 92 dbSNP
rs1021143883 96 dbSNP
rs1215365755 100 dbSNP
rs1443004753 101 dbSNP
rs1280837573 104 dbSNP
rs548801129 106 dbSNP
rs1347873706 107 dbSNP
rs532943533 111 dbSNP
rs746356468 112 dbSNP
rs1231136461 113 dbSNP
rs1360339560 115 dbSNP
rs1286716026 117 dbSNP
rs1429596087 118 dbSNP
rs111514659 119 dbSNP
rs1432783941 120 dbSNP
rs1374818746 121 dbSNP
rs1168971080 123 dbSNP
rs1035327301 126 dbSNP
rs1417172294 134 dbSNP
rs782397313 136 dbSNP
rs1473280177 147 dbSNP
rs991226274 153 dbSNP
rs1259695596 154 dbSNP
rs772498993 155 dbSNP
rs1208869057 156 dbSNP
rs1485617605 159 dbSNP
rs915758158 167 dbSNP
rs1275911518 194 dbSNP
rs963190020 197 dbSNP
rs1306060653 206 dbSNP
rs1295326252 209 dbSNP
rs546897556 210 dbSNP
rs1213615576 211 dbSNP
rs1379530339 213 dbSNP
rs1294563717 217 dbSNP
rs1412440678 220 dbSNP
rs781988778 223 dbSNP
rs1354299336 224 dbSNP
rs1308522703 227 dbSNP
rs1463470829 230 dbSNP
rs1352527221 232 dbSNP
rs782232587 233 dbSNP
rs566623155 237 dbSNP
rs528894963 240 dbSNP
rs1420355069 241 dbSNP
rs1186101099 243 dbSNP
rs185730192 256 dbSNP
rs1179412441 257 dbSNP
rs1251074643 261 dbSNP
rs1052203959 265 dbSNP
rs1274593367 266 dbSNP
rs1231076342 267 dbSNP
rs911872334 271 dbSNP
rs1288489697 273 dbSNP
rs943459907 282 dbSNP
rs1393037356 283 dbSNP
rs190434681 286 dbSNP
rs568868009 295 dbSNP
rs537980432 302 dbSNP
rs145595067 305 dbSNP
rs1412767874 314 dbSNP
rs1161425165 318 dbSNP
rs1417846817 320 dbSNP
rs1250507627 324 dbSNP
rs78999415 335 dbSNP
rs1470049678 336 dbSNP
rs1251551412 338 dbSNP
rs1211417493 339 dbSNP
rs539616096 341 dbSNP
rs1333760159 346 dbSNP
rs1260800590 350 dbSNP
rs1042651255 352 dbSNP
rs1314629779 356 dbSNP
rs1306120815 357 dbSNP
rs902780420 366 dbSNP
rs1003776285 370 dbSNP
rs1323702756 372 dbSNP
rs1440406267 373 dbSNP
rs1035777608 380 dbSNP
rs553643545 388 dbSNP
rs1451644561 392 dbSNP
rs1363303428 396 dbSNP
rs782509384 408 dbSNP
rs1177369847 415 dbSNP
rs781943889 420 dbSNP
rs782670538 424 dbSNP
rs1013105157 428 dbSNP
rs1467744629 432 dbSNP
rs1022721201 434 dbSNP
rs140854698 438 dbSNP
rs1484585703 440 dbSNP
rs973243207 446 dbSNP
rs542209483 451 dbSNP
rs1259653347 453 dbSNP
rs1234905126 455 dbSNP
rs760903424 455 dbSNP
rs1350013196 458 dbSNP
rs1026115131 463 dbSNP
rs782053663 464 dbSNP
rs987376231 465 dbSNP
rs1326816966 466 dbSNP
rs1297908349 475 dbSNP
rs150101677 478 dbSNP
rs1384278531 480 dbSNP
rs1303543142 492 dbSNP
rs1437123321 493 dbSNP
rs943363111 496 dbSNP
rs975271473 503 dbSNP
rs1375175525 504 dbSNP
rs1194816195 508 dbSNP
rs1426419070 510 dbSNP
rs575222789 511 dbSNP
rs544331990 512 dbSNP
rs564218511 520 dbSNP
rs532977601 521 dbSNP
rs540014740 522 dbSNP
rs560401927 525 dbSNP
rs1210079372 527 dbSNP
rs529220984 529 dbSNP
rs549251678 535 dbSNP
rs1252874911 541 dbSNP
rs1225484349 542 dbSNP
rs138465451 548 dbSNP
rs1293975164 549 dbSNP
rs776257544 555 dbSNP
rs1416638453 562 dbSNP
rs1312764534 564 dbSNP
rs1430979686 565 dbSNP
rs1399055838 574 dbSNP
rs371992802 575 dbSNP
rs1460147038 582 dbSNP
rs1372205375 585 dbSNP
rs1188232906 586 dbSNP
rs895511919 587 dbSNP
rs531312677 594 dbSNP
rs1187071440 595 dbSNP
rs1022606626 597 dbSNP
rs898919814 602 dbSNP
rs1274858298 613 dbSNP
rs1338522854 614 dbSNP
rs782773481 619 dbSNP
rs1273976082 621 dbSNP
rs1235406099 627 dbSNP
rs994567338 628 dbSNP
rs1332706654 636 dbSNP
rs782325797 637 dbSNP
rs375123162 646 dbSNP
rs1338115671 651 dbSNP
rs950565090 657 dbSNP
rs4275969 658 dbSNP
rs1327253856 660 dbSNP
rs1391122134 662 dbSNP
rs571329673 667 dbSNP
rs1018859940 668 dbSNP
rs1414987255 672 dbSNP
rs540032130 673 dbSNP
rs142682673 681 dbSNP
rs868994658 684 dbSNP
rs567048138 685 dbSNP
rs1215766689 686 dbSNP
rs781834777 691 dbSNP
rs1272621939 699 dbSNP
rs535810187 702 dbSNP
rs555622942 704 dbSNP
rs978135732 706 dbSNP
rs1352952467 709 dbSNP
rs1278221839 711 dbSNP
rs575261898 712 dbSNP
rs924135284 716 dbSNP
rs782473625 719 dbSNP
rs538939543 734 dbSNP
rs782698388 735 dbSNP
rs1328400799 737 dbSNP
rs868916933 740 dbSNP
rs868933576 742 dbSNP
rs1391911116 749 dbSNP
rs537814899 750 dbSNP
rs1400718698 759 dbSNP
rs1409569641 762 dbSNP
rs557841363 781 dbSNP
rs1156695041 782 dbSNP
rs1057154492 790 dbSNP
rs1395423297 791 dbSNP
rs836903 792 dbSNP
rs1467300609 793 dbSNP
rs540720753 797 dbSNP
rs1216773856 800 dbSNP
rs560129228 804 dbSNP
rs573764262 807 dbSNP
rs1205034944 810 dbSNP
rs1349281519 812 dbSNP
rs782656849 819 dbSNP
rs1273841774 825 dbSNP
rs1431044986 826 dbSNP
rs1346433599 827 dbSNP
rs1315662628 831 dbSNP
rs1419018008 831 dbSNP
rs1044104543 840 dbSNP
rs898802047 847 dbSNP
rs1452267860 853 dbSNP
rs1424239795 858 dbSNP
rs1187281304 861 dbSNP
rs994616367 868 dbSNP
rs1240396644 869 dbSNP
rs1192644279 872 dbSNP
rs1486049679 873 dbSNP
rs1283012116 877 dbSNP
rs1209397943 879 dbSNP
rs1347553709 890 dbSNP
rs782255575 895 dbSNP
rs1363719637 898 dbSNP
rs1267884490 900 dbSNP
rs1398785326 901 dbSNP
rs182978574 903 dbSNP
rs1432807175 907 dbSNP
rs1008723018 908 dbSNP
rs1019159395 913 dbSNP
rs562744998 920 dbSNP
rs1170930095 924 dbSNP
rs782417270 926 dbSNP
rs566802190 930 dbSNP
rs186240519 933 dbSNP
rs1259730170 936 dbSNP
rs1186403343 938 dbSNP
rs1483232641 942 dbSNP
rs1233815853 943 dbSNP
rs1207136266 949 dbSNP
rs1306140746 951 dbSNP
rs137943106 956 dbSNP
rs749973337 956 dbSNP
rs1334865194 959 dbSNP
rs1294647933 961 dbSNP
rs144086076 968 dbSNP
rs1298518709 969 dbSNP
rs566985543 973 dbSNP
rs1352581165 976 dbSNP
rs112312644 977 dbSNP
rs1462211191 977 dbSNP
rs924042628 978 dbSNP
rs1162961707 981 dbSNP
rs1423732114 988 dbSNP
rs147339203 991 dbSNP
rs192462045 995 dbSNP
rs369930956 1008 dbSNP
rs916713420 1011 dbSNP
rs948346128 1012 dbSNP
rs782279130 1015 dbSNP
rs1038617150 1019 dbSNP
rs1197597489 1023 dbSNP
rs1274497174 1024 dbSNP
rs1468672117 1024 dbSNP
rs557777829 1026 dbSNP
rs1230983644 1039 dbSNP
rs1320603882 1041 dbSNP
rs1307574828 1042 dbSNP
rs1370885454 1047 dbSNP
rs182378875 1049 dbSNP
rs117644085 1056 dbSNP
rs1441911808 1060 dbSNP
rs148758562 1068 dbSNP
rs797036343 1068 dbSNP
rs573778660 1071 dbSNP
rs781108196 1073 dbSNP
rs1161848979 1075 dbSNP
rs1417905032 1087 dbSNP
rs1047544934 1093 dbSNP
rs886197203 1094 dbSNP
rs781987627 1096 dbSNP
rs1009023039 1097 dbSNP
rs1254426140 1109 dbSNP
rs1040224471 1115 dbSNP
rs900320723 1125 dbSNP
rs1260857831 1127 dbSNP
rs996074231 1127 dbSNP
rs1217828055 1142 dbSNP
rs1351506749 1144 dbSNP
rs542808528 1148 dbSNP
rs562778566 1151 dbSNP
rs968056709 1158 dbSNP
rs782098958 1163 dbSNP
rs1234681291 1165 dbSNP
rs1372917337 1176 dbSNP
rs1301472839 1181 dbSNP
rs1386443261 1182 dbSNP
rs999492207 1184 dbSNP
rs1290750081 1188 dbSNP
rs1452251605 1189 dbSNP
rs1360507201 1190 dbSNP
rs1031382611 1192 dbSNP
rs960842984 1194 dbSNP
rs1436895455 1199 dbSNP
rs1393685825 1203 dbSNP
rs17679495 1207 dbSNP
rs1432281799 1209 dbSNP
rs1261817447 1210 dbSNP
rs1187823755 1217 dbSNP
rs916781353 1218 dbSNP
rs797039584 1221 dbSNP
rs969524436 1221 dbSNP
rs112760853 1222 dbSNP
rs111492207 1223 dbSNP
rs836904 1224 dbSNP
rs1327314965 1228 dbSNP
rs1297793611 1231 dbSNP
rs782816430 1235 dbSNP
rs930176595 1237 dbSNP
rs141528094 1243 dbSNP
rs550728675 1244 dbSNP
rs1373997279 1246 dbSNP
rs1172431008 1247 dbSNP
rs547203203 1251 dbSNP
rs944484817 1252 dbSNP
rs1172098614 1256 dbSNP
rs1040510187 1258 dbSNP
rs561008627 1262 dbSNP
rs1261860346 1271 dbSNP
rs1188538714 1273 dbSNP
rs900372406 1275 dbSNP
rs782122654 1279 dbSNP
rs1253810655 1283 dbSNP
rs1199717523 1285 dbSNP
rs1339842453 1287 dbSNP
rs782222152 1289 dbSNP
rs529474773 1295 dbSNP
rs1317353905 1300 dbSNP
rs1294029905 1304 dbSNP
rs931810230 1308 dbSNP
rs1339290219 1309 dbSNP
rs1334101373 1310 dbSNP
rs187869181 1312 dbSNP
rs544521712 1314 dbSNP
rs1399122245 1315 dbSNP
rs1299478987 1317 dbSNP
rs150842589 1325 dbSNP
rs1422244973 1330 dbSNP
rs999376096 1335 dbSNP
rs531922423 1343 dbSNP
rs880002780 1346 dbSNP
rs1438143548 1348 dbSNP
rs551645459 1349 dbSNP
rs1252428795 1357 dbSNP
rs1196954999 1359 dbSNP
rs563516843 1363 dbSNP
rs1457539464 1365 dbSNP
rs896467811 1366 dbSNP
rs1273878750 1368 dbSNP
rs1235151787 1369 dbSNP
rs112028398 1371 dbSNP
rs1284084686 1376 dbSNP
rs1024134732 1379 dbSNP
rs1240420725 1382 dbSNP
rs969577709 1386 dbSNP
rs1307581526 1387 dbSNP
rs1444118599 1390 dbSNP
rs1399167917 1393 dbSNP
rs1326180504 1401 dbSNP
rs974244559 1402 dbSNP
rs1387985098 1408 dbSNP
rs1162531317 1412 dbSNP
rs1027115525 1416 dbSNP
rs1365323242 1417 dbSNP
rs1176610009 1419 dbSNP
rs1253790186 1420 dbSNP
rs534170856 1421 dbSNP
rs983409579 1422 dbSNP
rs1206204580 1427 dbSNP
rs1353553359 1437 dbSNP
rs1307515547 1442 dbSNP
rs1239800782 1443 dbSNP
rs553991070 1447 dbSNP
rs1303631837 1448 dbSNP
rs1438194897 1450 dbSNP
rs1328822870 1451 dbSNP
rs907558590 1455 dbSNP
rs944368138 1457 dbSNP
rs1401207948 1458 dbSNP
rs1362323533 1459 dbSNP
rs567710482 1464 dbSNP
rs921694599 1468 dbSNP
rs1395483833 1481 dbSNP
rs1193115681 1483 dbSNP
rs931695797 1489 dbSNP
rs1477184633 1490 dbSNP
rs1246196451 1491 dbSNP
rs536451749 1498 dbSNP
rs1043560373 1503 dbSNP
rs144322840 1506 dbSNP
rs1282972310 1507 dbSNP
rs1220596728 1514 dbSNP
rs1342516879 1515 dbSNP
rs1273896840 1523 dbSNP
rs1430743993 1527 dbSNP
rs1341867722 1534 dbSNP
rs1296216122 1548 dbSNP
rs1399383778 1552 dbSNP
rs782559889 1560 dbSNP
rs781907521 1561 dbSNP
rs896522979 1562 dbSNP
rs576292768 1566 dbSNP
rs111785853 1569 dbSNP
rs1168719060 1570 dbSNP
rs558793638 1571 dbSNP
rs1261148516 1572 dbSNP
rs1193543418 1574 dbSNP
rs113674863 1576 dbSNP
rs782245737 1580 dbSNP
rs1208390413 1581 dbSNP
rs1311982268 1583 dbSNP
rs782359653 1584 dbSNP
rs1319361873 1587 dbSNP
rs1275804025 1591 dbSNP
rs951512344 1593 dbSNP
rs192596638 1596 dbSNP
rs747560731 1598 dbSNP
rs1358390105 1601 dbSNP
rs1020277688 1603 dbSNP
rs1467422438 1609 dbSNP
rs62107025 1610 dbSNP
rs1170138973 1611 dbSNP
rs1421531513 1611 dbSNP
rs540416712 1611 dbSNP
rs561389627 1611 dbSNP
rs782654294 1611 dbSNP
rs76003440 1612 dbSNP
rs1483100904 1615 dbSNP
rs1233868480 1617 dbSNP
rs1198850573 1618 dbSNP
rs1255589344 1621 dbSNP
rs965624900 1621 dbSNP
rs1334922743 1622 dbSNP
rs976157433 1622 dbSNP
rs560825313 1623 dbSNP
rs1226555428 1624 dbSNP
rs1378140875 1628 dbSNP
rs1279961307 1631 dbSNP
rs1449271094 1632 dbSNP
rs1398310759 1638 dbSNP
rs528603010 1644 dbSNP
rs1461994314 1648 dbSNP
rs529845430 1651 dbSNP
rs931746804 1656 dbSNP
rs782193392 1663 dbSNP
rs1423789142 1665 dbSNP
rs543105416 1667 dbSNP
rs1180960045 1679 dbSNP
rs1438236779 1680 dbSNP
rs562775721 1688 dbSNP
rs1177655587 1689 dbSNP
rs1488493701 1691 dbSNP
rs1219243875 1696 dbSNP
rs182629340 1698 dbSNP
rs1284889175 1699 dbSNP
rs1241966610 1706 dbSNP
rs935156700 1707 dbSNP
rs1308737487 1709 dbSNP
rs1441985905 1713 dbSNP
rs1291931171 1722 dbSNP
rs1457833752 1723 dbSNP
rs1346245137 1724 dbSNP
rs844372 1725 dbSNP
rs1052394711 1727 dbSNP
rs551681639 1729 dbSNP
rs1380096596 1730 dbSNP
rs1177600148 1739 dbSNP
rs1433449975 1744 dbSNP
rs1189006734 1753 dbSNP
rs1268832537 1753 dbSNP
rs1487877146 1755 dbSNP
rs113895681 1756 dbSNP
rs527693703 1757 dbSNP
rs1351205103 1768 dbSNP
rs1285098976 1775 dbSNP
rs1234234454 1779 dbSNP
rs374276265 1783 dbSNP
rs1314226827 1784 dbSNP
rs949290893 1787 dbSNP
rs547720484 1790 dbSNP
rs1386213624 1792 dbSNP
rs1362784076 1798 dbSNP
rs1300529106 1804 dbSNP
rs1398748896 1807 dbSNP
rs1360253188 1808 dbSNP
rs1174729408 1809 dbSNP
rs1466218044 1815 dbSNP
rs1378938304 1819 dbSNP
rs1173559010 1827 dbSNP
rs1432043304 1830 dbSNP
rs1423779053 1831 dbSNP
rs905165519 1834 dbSNP
rs995619212 1842 dbSNP
rs1262190189 1843 dbSNP
rs1048507530 1845 dbSNP
rs1484113245 1846 dbSNP
rs1254440698 1847 dbSNP
rs568701404 1848 dbSNP
rs1318667741 1850 dbSNP
rs140043328 1851 dbSNP
rs1217331627 1867 dbSNP
rs536780940 1870 dbSNP
rs531216806 1879 dbSNP
rs1398115436 1882 dbSNP
rs1400545812 1882 dbSNP
rs1300693309 1885 dbSNP
rs1465270039 1891 dbSNP
rs551300903 1907 dbSNP
rs187287411 1909 dbSNP
rs1028647276 1910 dbSNP
rs953033356 1913 dbSNP
rs1172270101 1919 dbSNP
rs558592888 1926 dbSNP
rs1422755681 1927 dbSNP
rs1188199078 1928 dbSNP
rs1425281287 1929 dbSNP
rs1253871938 1931 dbSNP
rs925023538 1933 dbSNP
rs956448068 1936 dbSNP
rs1458435721 1944 dbSNP
rs1260059279 1947 dbSNP
rs1196759861 1956 dbSNP
rs1317408956 1959 dbSNP
rs988380387 1968 dbSNP
rs1312549550 1970 dbSNP
rs1398945379 1974 dbSNP
rs1451451063 1974 dbSNP
rs1463567774 1974 dbSNP
rs201183491 1974 dbSNP
rs782139198 1977 dbSNP
rs1366491910 1981 dbSNP
rs1186647395 1984 dbSNP
rs1440090990 1986 dbSNP
rs572259207 1988 dbSNP
rs1240184533 1989 dbSNP
rs782117504 1989 dbSNP
rs1457355664 1990 dbSNP
rs1290729289 1992 dbSNP
rs1212149721 2001 dbSNP
rs1354938069 2005 dbSNP
rs1265389732 2007 dbSNP
rs949340062 2008 dbSNP
rs1044990584 2013 dbSNP
rs1444182460 2018 dbSNP
rs1334626492 2022 dbSNP
rs370456559 2031 dbSNP
rs1407003858 2042 dbSNP
rs61694170 2045 dbSNP
rs796878191 2045 dbSNP
rs926633013 2047 dbSNP
rs202019363 2048 dbSNP
rs1162856205 2049 dbSNP
rs540964706 2052 dbSNP
rs1157049485 2059 dbSNP
rs1439391673 2061 dbSNP
rs1048392506 2065 dbSNP
rs1201023469 2070 dbSNP
rs200988953 2073 dbSNP
rs558691970 2082 dbSNP
rs1267228435 2084 dbSNP
rs1218012615 2087 dbSNP
rs1356267050 2087 dbSNP
rs1284369935 2089 dbSNP
rs1237497919 2094 dbSNP
rs1349577811 2116 dbSNP
rs887194697 2117 dbSNP
rs570351776 2122 dbSNP
rs1275085305 2127 dbSNP
rs1437902427 2128 dbSNP
rs1328878507 2129 dbSNP
rs1302448768 2131 dbSNP
rs574079693 2133 dbSNP
rs1362214153 2134 dbSNP
rs1296179639 2135 dbSNP
rs1399912397 2149 dbSNP
rs1041624494 2151 dbSNP
rs1174569665 2161 dbSNP
rs115985612 2162 dbSNP
rs1377185342 2172 dbSNP
rs997533153 2181 dbSNP
rs1028531339 2184 dbSNP
rs1261462573 2198 dbSNP
rs563018720 2200 dbSNP
rs953080946 2207 dbSNP
rs1000492350 2211 dbSNP
rs1220646190 2212 dbSNP
rs781974107 2212 dbSNP
rs1342223150 2217 dbSNP
rs1282162147 2219 dbSNP
rs1219155587 2223 dbSNP
rs1342235801 2226 dbSNP
rs1296275977 2230 dbSNP
rs114719445 2234 dbSNP
rs56849372 2237 dbSNP
rs917770396 2244 dbSNP
rs192153055 2248 dbSNP
rs762310457 2260 dbSNP
rs1405428706 2261 dbSNP
rs980718977 2263 dbSNP
rs1171543785 2266 dbSNP
rs184699829 2270 dbSNP
rs926535242 2271 dbSNP
rs1422026443 2276 dbSNP
rs1478851200 2276 dbSNP
rs1186476594 2284 dbSNP
rs781792097 2288 dbSNP
rs1211796288 2289 dbSNP
rs931179488 2291 dbSNP
rs984141822 2293 dbSNP
rs1262136158 2297 dbSNP
rs1198658042 2298 dbSNP
rs782164526 2299 dbSNP
rs1319431222 2301 dbSNP
rs940131785 2318 dbSNP
rs1276173971 2321 dbSNP
rs1213967627 2325 dbSNP
rs528033644 2333 dbSNP
rs1446069408 2334 dbSNP
rs76385318 2334 dbSNP
rs901380022 2336 dbSNP
rs1332304171 2344 dbSNP
rs1467211252 2353 dbSNP
rs868920564 2354 dbSNP
rs1398227976 2355 dbSNP
rs932812293 2370 dbSNP
rs1406529396 2371 dbSNP
rs1416394416 2375 dbSNP
rs1180423501 2382 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cucuaccaccucaucgAGGUCCg 5'
                          |||||| 
Target 5' ----------------UCCAGGa 3'
 		1 - 7
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000335117.8 | 3UTR | CCAGGAAAAAAAAAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000335117.8 | 3UTR | UCCAGGAAAAAAAAAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.02 0.49 0.000 0.5 4 Click to see details
THCA 0.02 0.49 0.000 0.5 4 Click to see details
THCA 0.02 0.49 0.000 0.5 4 Click to see details
57 hsa-miR-4254 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061595 BTG2 BTG anti-proliferation factor 2 2 4
MIRT306302 ABCC5 ATP binding cassette subfamily C member 5 2 2
MIRT353697 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT442351 RAB6B RAB6B, member RAS oncogene family 2 2
MIRT448535 RIMS4 regulating synaptic membrane exocytosis 4 2 2
MIRT449881 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT457644 ZNF69 zinc finger protein 69 2 2
MIRT458620 TRIM72 tripartite motif containing 72 2 2
MIRT470963 PKM pyruvate kinase, muscle 2 2
MIRT476285 GMFB glia maturation factor beta 2 10
MIRT477615 EFNA3 ephrin A3 2 2
MIRT482761 TMEM126B transmembrane protein 126B 2 2
MIRT492535 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT502995 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT508467 HOXB6 homeobox B6 2 4
MIRT520190 WBP2 WW domain binding protein 2 2 2
MIRT525117 PRKD2 protein kinase D2 2 2
MIRT525773 SOD2 superoxide dismutase 2 2 2
MIRT526411 TFAM transcription factor A, mitochondrial 2 2
MIRT528152 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT534111 SOGA3 SOGA family member 3 2 2
MIRT538026 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT539288 ANGEL2 angel homolog 2 2 2
MIRT541103 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT550999 SUOX sulfite oxidase 2 2
MIRT562165 HOXA13 homeobox A13 2 2
MIRT570122 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT571104 DENND4B DENN domain containing 4B 2 2
MIRT574099 VASN vasorin 2 2
MIRT611153 ZNF486 zinc finger protein 486 2 2
MIRT612252 STX1B syntaxin 1B 2 4
MIRT614808 RIOK3 RIO kinase 3 2 2
MIRT622153 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT624286 CRCP CGRP receptor component 2 2
MIRT624875 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT627479 STRN striatin 2 2
MIRT641273 AMDHD2 amidohydrolase domain containing 2 2 2
MIRT645622 TSPAN6 tetraspanin 6 2 2
MIRT650226 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT657507 HBEGF heparin binding EGF like growth factor 2 2
MIRT660811 AHCY adenosylhomocysteinase 2 2
MIRT667439 METTL14 methyltransferase like 14 2 2
MIRT693744 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT697852 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT698719 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT699980 RREB1 ras responsive element binding protein 1 2 2
MIRT700689 POLR3D RNA polymerase III subunit D 2 2
MIRT703267 GNL3L G protein nucleolar 3 like 2 2
MIRT703787 FAM102B family with sequence similarity 102 member B 2 2
MIRT711277 SDR9C7 short chain dehydrogenase/reductase family 9C member 7 2 2
MIRT711863 TRAF2 TNF receptor associated factor 2 2 2
MIRT712451 KHNYN KH and NYN domain containing 2 2
MIRT714449 UBXN2A UBX domain protein 2A 2 2
MIRT718846 SNX20 sorting nexin 20 2 2
MIRT721333 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT723315 PRKCH protein kinase C eta 2 2
MIRT736659 CYP2B6 cytochrome P450 family 2 subfamily B member 6 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4254 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4254 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4254 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4254 Sunitinib 5329102 NSC750690 approved sensitive tissue
hsa-miR-4254 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4254 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)
hsa-miR-4254 Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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