pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol UGT8   
Synonyms CGT, UGT4
Description UDP glycosyltransferase 8
Transcript NM_001128174   
Other Transcripts NM_003360   
Expression
Putative miRNA Targets on UGT8
3'UTR of UGT8
(miRNA target sites are highlighted)
>UGT8|NM_001128174|3'UTR
   1 GCCAACAGCCCAGGTGATAGAAATAAATTGGTTCACTCATTGAATTTTTATTGCTATTATTTAGTCTAACAGCTACTAAA
  81 AGTAAAACATCAGTAAACAATTCTAACATGCCCTTATGAGATCTACTAATGAAATTCTGTGGAATTAAGATGGCTGTAAA
 161 AAGCACAAACCTAAAATGCAGAAATGTATTTTATTCAAATACTGATGTAGAGAGTTTTGGCACTGAACCTTTTAGAAGCC
 241 TTAATTATTTAAATCAATTCAGTGACTGTGTCAGACCTTAGTTTTAAATCTTGATATGTGCGTGTCCCGGATCAGGAATG
 321 GTTTCATTTTTCTTAATAATGTGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGTGTTTGTGTGTGTGTGTGTGTGTCCTA
 401 ATTAAGAGAATTTTTACTGGCTGCTTGTTACATTTGTTGAGGGTACAACACACTCAAGAATAAAGTAAAAGGATAGTCAG
 481 GATCCAGATGTTTCTTTTCTAGCATTTAATGTGTGTGAACTCAGAACACTACCATGAAAGAACACTTCCCCCCAAAACTG
 561 GATGCAGAGGAAGAAAAAAAAAAAAGAAATGGCACAGTTTTTTGTATTTTTTTTTTTAGTTATTTTTTGTTGTTGTTGTT
 641 TGTATTGTTTTTCTTTTCTGATAGAGTATGGCCACTTCTGGGGGAAAAACATGTAATTAAGTAAATGTATACATTGGTTT
 721 TCACGTTTTACTTTTGTTTTCCCACTACCAATAATTTTCCTCTGGAAGAATTTTATAGTTTTTTCTATTTCATTTTAATG
 801 AGTAACAATATGTTAAATGCATAATTAAGACAAAGCAATGAAATTCTGACTTTATTCAAAGTACTGAAGATTATTGCTTC
 881 TAGGGCATTTTTAAACAGCACCATTGTATTGTTGAATGTTTATGTAACTGATGGCTTTTCTATAATGTAATTTTTGAATG
 961 TTCAGGTGTTACATTTCCAAAGTTTAACTTTTAAAAAACCATCTTCTGATCCCTTTTATTGTCTGGGCCATACAATCTAT
1041 ATTACATAGGTGCCAACATTTAATTCTTTTAAATGGAACATTTGCAGTTTTCCATATTGGTACCTGCTTTTTCTGGAGAG
1121 GTTTGAGATCTTGTTAACAAATCAGACTTTACACTATATACAGATGTGACAGATAAATTGAACCACTTGTTTGTGAAAAT
1201 GAGTTCCTGTCATCTTCCTCATTCACTCAGCCCTCACCCCAGCAGCCTTTTCCGGTCATTGTAGCTGACATGGAGCAGTG
1281 ACAGTATTCATTTGAGAACAGGGATGCAAGTCACAGACATCATAAAATCAGGGTCTCCCTGCTGAAGCATTCACTAGTTG
1361 GCAACTATGAATTTATTCCATGTCATTCTGTTTACTTAGCACTTGCACTACCCTTGTTGGTTGAGTGTATGCTTTATTTG
1441 TTTCTAGTTTGAAATCCCACATCTGATAGCTGAGAGTAGGCAAATACAACATTTACCTAATGTCATTCACTAACATGGAA
1521 GAGTTGTGAAAATTCTAGAGTGCTGTAAATCCTTGGCATACACTATGACAAACAACTTCATTACTCTCCCACCAGGAGCT
1601 GCTCTCCTGCACTTAGAAATAATGTCACAAGTAGTTTTCTAATGTACAATGCAGACAAATGTACTGCTCTCTGAATACTT
1681 GAAGAAATGGTATTATACATACATAGAAACTTATTAGTTATACCTTTTCACAATCTTATTACGATGTTGCCGTTAAAAGG
1761 GAAAAAAGACACAGGCAATGAATGGTGGGATAGTAAGAGGACTTAGAGTGTATGAATGAGTTGATTTTACTTTTTTGGAA
1841 TTTGATTAAGTTGACAGTAGGCACTGATTGGATGATTAAACATAAGTTAATCTCCACTGTGATAAAAACTTAAATAATAA
1921 ACATGATTTAAAATAGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuUAGUGUUUAC---------AGGAAUUAUc 5'
            |||| :||||         |:||||||| 
Target 5' ggATCAGGAATGGTTTCATTTTTCTTAATAa 3'
309 - 339 160.00 -12.60
2
miRNA  3' cuuAGUGUUUACAGGAAUUAuc 5'
             |: :|:| | |||||||  
Target 5' accTTTTAGAAG-CCTTAATta 3'
227 - 247 134.00 -6.30
3
miRNA  3' cuuagUGUUUACA-------GGAAUUAUc 5'
               ||||||||       :|| |||| 
Target 5' tgcagACAAATGTACTGCTCTCTGAATAc 3'
1650 - 1678 129.00 -6.41
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31518516 14 COSMIC
COSN27001139 21 COSMIC
COSN31605835 21 COSMIC
COSN31485396 39 COSMIC
COSN28864437 54 COSMIC
COSN30108006 76 COSMIC
COSN23063494 98 COSMIC
COSN26650290 111 COSMIC
COSN26643435 256 COSMIC
COSN30161169 275 COSMIC
COSN7725554 286 COSMIC
COSN15662127 354 COSMIC
COSN15939061 378 COSMIC
COSN16957339 380 COSMIC
COSN31550790 390 COSMIC
COSN31571584 409 COSMIC
COSN22803737 444 COSMIC
COSN28992778 586 COSMIC
COSN29010602 586 COSMIC
COSN17775459 723 COSMIC
COSN1981315 802 COSMIC
COSN16406367 1105 COSMIC
COSN6791856 1148 COSMIC
COSN16470511 1158 COSMIC
COSN16613695 1622 COSMIC
COSN5051027 1748 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs760070749 2 dbSNP
rs1285355894 6 dbSNP
rs1486066165 9 dbSNP
rs9996273 10 dbSNP
rs1254413470 19 dbSNP
rs372484108 21 dbSNP
rs1464223282 22 dbSNP
rs756838004 29 dbSNP
rs375803468 37 dbSNP
rs750170015 40 dbSNP
rs758395837 41 dbSNP
rs1395140987 46 dbSNP
rs1436108118 49 dbSNP
rs779828142 50 dbSNP
rs747165031 51 dbSNP
rs1395752996 53 dbSNP
rs1332918390 60 dbSNP
rs989899768 61 dbSNP
rs539907680 62 dbSNP
rs918005415 71 dbSNP
rs1308896951 76 dbSNP
rs368895157 93 dbSNP
rs1364838730 99 dbSNP
rs946935680 101 dbSNP
rs978680399 107 dbSNP
rs929499429 109 dbSNP
rs1276031608 110 dbSNP
rs1047871406 112 dbSNP
rs1400651537 119 dbSNP
rs533072316 126 dbSNP
rs909480072 129 dbSNP
rs1462035008 134 dbSNP
rs1198847513 137 dbSNP
rs934233898 138 dbSNP
rs551184110 140 dbSNP
rs759517182 148 dbSNP
rs1374303296 155 dbSNP
rs371889174 166 dbSNP
rs1448529574 170 dbSNP
rs147821436 182 dbSNP
rs911264771 187 dbSNP
rs1440529922 207 dbSNP
rs1255385710 209 dbSNP
rs1236075600 215 dbSNP
rs191391576 219 dbSNP
rs1480967970 221 dbSNP
rs1276871870 228 dbSNP
rs1226409564 230 dbSNP
rs942659098 231 dbSNP
rs1038482054 238 dbSNP
rs1316041759 239 dbSNP
rs898586867 240 dbSNP
rs900202497 257 dbSNP
rs994239282 258 dbSNP
rs997191426 260 dbSNP
rs375788297 262 dbSNP
rs1397957509 270 dbSNP
rs1305663115 271 dbSNP
rs1047338111 273 dbSNP
rs907009743 277 dbSNP
rs1428604773 285 dbSNP
rs1365781977 289 dbSNP
rs1002778706 299 dbSNP
rs1377044836 302 dbSNP
rs141680233 303 dbSNP
rs150423330 307 dbSNP
rs774238564 309 dbSNP
rs138194865 310 dbSNP
rs1249587945 311 dbSNP
rs967551813 313 dbSNP
rs1482807716 316 dbSNP
rs1292762601 322 dbSNP
rs977160187 327 dbSNP
rs1394773251 334 dbSNP
rs1388928232 338 dbSNP
rs1240324900 339 dbSNP
rs924111997 339 dbSNP
rs1001823205 340 dbSNP
rs1338029040 340 dbSNP
rs771625987 340 dbSNP
rs779379928 340 dbSNP
rs1304519422 341 dbSNP
rs1330980337 342 dbSNP
rs959676229 344 dbSNP
rs1158957241 346 dbSNP
rs1231744628 348 dbSNP
rs1280104277 350 dbSNP
rs1409655874 350 dbSNP
rs1472272724 351 dbSNP
rs1269698482 352 dbSNP
rs143006953 352 dbSNP
rs955521832 352 dbSNP
rs1450103726 353 dbSNP
rs113192515 354 dbSNP
rs113496925 354 dbSNP
rs1276139415 354 dbSNP
rs1318636123 354 dbSNP
rs1330115079 354 dbSNP
rs1383691900 354 dbSNP
rs1386199424 354 dbSNP
rs1433796232 354 dbSNP
rs546746239 354 dbSNP
rs760175563 354 dbSNP
rs992153006 354 dbSNP
rs368393143 355 dbSNP
rs1318713941 356 dbSNP
rs911462754 356 dbSNP
rs1430012403 358 dbSNP
rs1174365452 362 dbSNP
rs763734891 364 dbSNP
rs1246344725 366 dbSNP
rs755482490 368 dbSNP
rs1466486932 370 dbSNP
rs1208608732 372 dbSNP
rs1246580025 372 dbSNP
rs950772159 372 dbSNP
rs1216963066 374 dbSNP
rs1270354032 374 dbSNP
rs1281412873 374 dbSNP
rs112659357 376 dbSNP
rs1491159175 376 dbSNP
rs1491387739 376 dbSNP
rs61375034 377 dbSNP
rs112000650 378 dbSNP
rs1388660388 378 dbSNP
rs1451599090 378 dbSNP
rs149001721 378 dbSNP
rs753470072 378 dbSNP
rs761524481 378 dbSNP
rs909343036 378 dbSNP
rs1210267099 380 dbSNP
rs556964477 382 dbSNP
rs1266437833 383 dbSNP
rs1239707898 391 dbSNP
rs1208653000 394 dbSNP
rs1392347742 398 dbSNP
rs1273136058 400 dbSNP
rs1449758518 407 dbSNP
rs1206794925 409 dbSNP
rs1195768652 420 dbSNP
rs1339607083 424 dbSNP
rs1296465950 425 dbSNP
rs1423701528 426 dbSNP
rs1477245696 433 dbSNP
rs1246435162 446 dbSNP
rs1381150717 447 dbSNP
rs374516160 449 dbSNP
rs1447206316 454 dbSNP
rs975443169 459 dbSNP
rs539966353 466 dbSNP
rs1431761024 468 dbSNP
rs1369888371 472 dbSNP
rs1047133208 473 dbSNP
rs1416413082 474 dbSNP
rs1180577890 489 dbSNP
rs1294445626 496 dbSNP
rs1234018154 501 dbSNP
rs933012283 502 dbSNP
rs149566050 510 dbSNP
rs111956030 512 dbSNP
rs1222788468 515 dbSNP
rs1300654615 527 dbSNP
rs1323220599 530 dbSNP
rs1055668396 533 dbSNP
rs1287508091 537 dbSNP
rs1227629593 549 dbSNP
rs1341207646 553 dbSNP
rs1411724321 556 dbSNP
rs1399524707 565 dbSNP
rs1293679236 566 dbSNP
rs1323683031 568 dbSNP
rs1245842542 570 dbSNP
rs1264575113 571 dbSNP
rs1348397461 574 dbSNP
rs1471291846 574 dbSNP
rs571381848 574 dbSNP
rs76112544 574 dbSNP
rs74609220 575 dbSNP
rs1250430032 577 dbSNP
rs945740126 593 dbSNP
rs1489272976 594 dbSNP
rs1244673935 595 dbSNP
rs1317369958 598 dbSNP
rs1354062736 598 dbSNP
rs1457447812 607 dbSNP
rs538530654 607 dbSNP
rs1287828448 612 dbSNP
rs1218695035 618 dbSNP
rs1263860886 619 dbSNP
rs1487663185 620 dbSNP
rs1190813766 621 dbSNP
rs1257696097 623 dbSNP
rs1042918628 627 dbSNP
rs1389860891 627 dbSNP
rs904391116 627 dbSNP
rs866522422 630 dbSNP
rs1163655045 633 dbSNP
rs1368242703 636 dbSNP
rs1423207997 639 dbSNP
rs1410520886 643 dbSNP
rs1001372125 645 dbSNP
rs10011060 649 dbSNP
rs13148598 652 dbSNP
rs1034703022 665 dbSNP
rs1190332123 670 dbSNP
rs1486032082 672 dbSNP
rs555961165 676 dbSNP
rs867434010 686 dbSNP
rs1464368316 691 dbSNP
rs1263720999 693 dbSNP
rs1011469416 700 dbSNP
rs1381439698 710 dbSNP
rs1021713426 711 dbSNP
rs1299395204 714 dbSNP
rs1024907269 725 dbSNP
rs1366330481 741 dbSNP
rs950803031 744 dbSNP
rs983535992 748 dbSNP
rs1016301989 752 dbSNP
rs1312357973 754 dbSNP
rs1375431126 761 dbSNP
rs963905189 776 dbSNP
rs974927913 779 dbSNP
rs1391679710 784 dbSNP
rs1286501982 786 dbSNP
rs1448714567 788 dbSNP
rs1352843357 801 dbSNP
rs922191990 803 dbSNP
rs1202119558 809 dbSNP
rs1213563792 813 dbSNP
rs1484239159 819 dbSNP
rs933566210 820 dbSNP
rs183307684 822 dbSNP
rs912868316 824 dbSNP
rs1300151669 831 dbSNP
rs1483325730 837 dbSNP
rs999045874 839 dbSNP
rs1365000144 851 dbSNP
rs1369591281 867 dbSNP
rs1030067662 871 dbSNP
rs1398336114 874 dbSNP
rs955552669 877 dbSNP
rs76681860 878 dbSNP
rs1042866795 883 dbSNP
rs754222891 886 dbSNP
rs1253690073 889 dbSNP
rs1372016344 897 dbSNP
rs1306737687 899 dbSNP
rs904254035 905 dbSNP
rs1443141575 909 dbSNP
rs188140889 912 dbSNP
rs1448586949 934 dbSNP
rs937199192 942 dbSNP
rs114309643 950 dbSNP
rs964290313 951 dbSNP
rs1419563210 953 dbSNP
rs974316849 960 dbSNP
rs532781679 961 dbSNP
rs929988030 966 dbSNP
rs983296764 967 dbSNP
rs1483463957 970 dbSNP
rs756753432 971 dbSNP
rs1203301675 980 dbSNP
rs1339093212 985 dbSNP
rs928712297 992 dbSNP
rs1247500710 999 dbSNP
rs1466648826 1001 dbSNP
rs1339192118 1004 dbSNP
rs1302457090 1005 dbSNP
rs1404116251 1012 dbSNP
rs879903156 1013 dbSNP
rs143215138 1017 dbSNP
rs1351810364 1029 dbSNP
rs1375893357 1031 dbSNP
rs749755419 1033 dbSNP
rs1164759177 1034 dbSNP
rs947300961 1039 dbSNP
rs1367818367 1040 dbSNP
rs1159899105 1041 dbSNP
rs1472927348 1046 dbSNP
rs886483137 1047 dbSNP
rs1180223240 1050 dbSNP
rs1004824557 1051 dbSNP
rs1268364412 1056 dbSNP
rs769088264 1062 dbSNP
rs1273040107 1063 dbSNP
rs1312231071 1067 dbSNP
rs191673452 1074 dbSNP
rs1330557578 1077 dbSNP
rs1208876789 1082 dbSNP
rs1285940131 1098 dbSNP
rs1260737469 1101 dbSNP
rs996767536 1102 dbSNP
rs774538180 1105 dbSNP
rs1325198239 1113 dbSNP
rs902871475 1130 dbSNP
rs955136657 1133 dbSNP
rs139016699 1134 dbSNP
rs913483771 1152 dbSNP
rs1239111947 1156 dbSNP
rs1409723960 1157 dbSNP
rs1156990012 1162 dbSNP
rs1469748508 1163 dbSNP
rs1378409748 1166 dbSNP
rs548800691 1167 dbSNP
rs1450163425 1171 dbSNP
rs1252795728 1180 dbSNP
rs978409767 1193 dbSNP
rs890227632 1203 dbSNP
rs544598695 1208 dbSNP
rs182294495 1229 dbSNP
rs1222703099 1230 dbSNP
rs1427922807 1231 dbSNP
rs746703406 1231 dbSNP
rs1007275045 1234 dbSNP
rs754501039 1239 dbSNP
rs531546783 1247 dbSNP
rs937081227 1254 dbSNP
rs1369926670 1255 dbSNP
rs60300934 1265 dbSNP
rs142240625 1267 dbSNP
rs1437057408 1271 dbSNP
rs1386349441 1272 dbSNP
rs964234275 1287 dbSNP
rs974768397 1288 dbSNP
rs1404006412 1291 dbSNP
rs1467324409 1297 dbSNP
rs1332363226 1300 dbSNP
rs917052933 1307 dbSNP
rs949923131 1312 dbSNP
rs1046993419 1313 dbSNP
rs1439807351 1323 dbSNP
rs1027222709 1331 dbSNP
rs146375282 1339 dbSNP
rs772160724 1345 dbSNP
rs1368153733 1353 dbSNP
rs1189577373 1355 dbSNP
rs1451795355 1362 dbSNP
rs1246717392 1366 dbSNP
rs982761845 1367 dbSNP
rs1215726342 1371 dbSNP
rs1280736679 1378 dbSNP
rs1319408647 1381 dbSNP
rs1218854508 1389 dbSNP
rs1004855582 1403 dbSNP
rs539455788 1412 dbSNP
rs1346663123 1415 dbSNP
rs928617560 1420 dbSNP
rs1037643348 1421 dbSNP
rs1362784877 1422 dbSNP
rs996241780 1431 dbSNP
rs550503919 1433 dbSNP
rs938771756 1433 dbSNP
rs1341090139 1444 dbSNP
rs111576577 1445 dbSNP
rs991500700 1448 dbSNP
rs15601 1461 dbSNP
rs1437584130 1462 dbSNP
rs1412877795 1465 dbSNP
rs1029485160 1466 dbSNP
rs954939132 1470 dbSNP
rs879399741 1475 dbSNP
rs1388715024 1477 dbSNP
rs1186407708 1484 dbSNP
rs915779935 1487 dbSNP
rs1473426855 1505 dbSNP
rs139672727 1512 dbSNP
rs1184768905 1515 dbSNP
rs1485090575 1516 dbSNP
rs947238400 1521 dbSNP
rs1274838222 1522 dbSNP
rs142930459 1526 dbSNP
rs903113023 1527 dbSNP
rs866189711 1532 dbSNP
rs1199343249 1535 dbSNP
rs1020576540 1540 dbSNP
rs1381215745 1545 dbSNP
rs1051429955 1550 dbSNP
rs566865488 1560 dbSNP
rs890090072 1567 dbSNP
rs1285880232 1574 dbSNP
rs1007348705 1585 dbSNP
rs1413000476 1589 dbSNP
rs1354921067 1605 dbSNP
rs1308797329 1617 dbSNP
rs1017360468 1623 dbSNP
rs1411939198 1632 dbSNP
rs1478883058 1634 dbSNP
rs1170146800 1645 dbSNP
rs534268447 1646 dbSNP
rs1423244118 1649 dbSNP
rs1408454983 1650 dbSNP
rs186612288 1655 dbSNP
rs1416571117 1659 dbSNP
rs900020943 1662 dbSNP
rs773336345 1675 dbSNP
rs1474555580 1697 dbSNP
rs1350262766 1703 dbSNP
rs1435605122 1706 dbSNP
rs1183833075 1715 dbSNP
rs79505369 1716 dbSNP
rs958706484 1718 dbSNP
rs991286735 1720 dbSNP
rs1341798836 1722 dbSNP
rs1400129421 1723 dbSNP
rs951682095 1724 dbSNP
rs1277039140 1734 dbSNP
rs766376068 1743 dbSNP
rs192572095 1744 dbSNP
rs1230367475 1747 dbSNP
rs1371445793 1752 dbSNP
rs556588197 1753 dbSNP
rs1351987043 1756 dbSNP
rs150749940 1759 dbSNP
rs915983531 1760 dbSNP
rs1461398059 1764 dbSNP
rs941243843 1769 dbSNP
rs1267431171 1774 dbSNP
rs969178957 1776 dbSNP
rs978635206 1778 dbSNP
rs185456804 1784 dbSNP
rs1489301021 1785 dbSNP
rs924400419 1788 dbSNP
rs1416862173 1790 dbSNP
rs775377810 1796 dbSNP
rs1241628008 1803 dbSNP
rs560079943 1806 dbSNP
rs1474513408 1809 dbSNP
rs934601444 1810 dbSNP
rs1212943191 1818 dbSNP
rs1465276568 1821 dbSNP
rs1270008511 1827 dbSNP
rs139071426 1829 dbSNP
rs911596956 1830 dbSNP
rs1404589085 1850 dbSNP
rs542312025 1850 dbSNP
rs942995772 1851 dbSNP
rs1306474419 1854 dbSNP
rs1161569824 1855 dbSNP
rs532012626 1870 dbSNP
rs1301675828 1876 dbSNP
rs1420260877 1876 dbSNP
rs1296968013 1877 dbSNP
rs1390013299 1878 dbSNP
rs1450927837 1883 dbSNP
rs898930421 1883 dbSNP
rs1324184836 1889 dbSNP
rs1176288137 1898 dbSNP
rs1449749285 1910 dbSNP
rs890522896 1911 dbSNP
rs560789249 1922 dbSNP
rs1009081331 1923 dbSNP
rs1020440665 1924 dbSNP
rs1380313756 1925 dbSNP
rs1245765391 1926 dbSNP
rs1260240642 1929 dbSNP
rs377234423 1931 dbSNP
rs994973539 1936 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000310836.6 | 3UTR | UAAUAAUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000310836.6 | 3UTR | UAAUAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGUGUGUGUUUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000310836.6 | 3UTR | AAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGUGUGUGUUUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000310836.6 | 3UTR | AUAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGUGUGUGUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000310836.6 | 3UTR | UAAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000310836.6 | 3UTR | UAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGUGUGUGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000310836.6 | 3UTR | UAAUAAUGUGUGUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | AAUAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | AUCAGGAAUGGUUUCAUUUUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | UAAUAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000310836.6 | 3UTR | AUAAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | AUGUGUGUGUGUGUAUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | UAAUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000310836.6 | 3UTR | UAAUAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGUGUGUGUGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000310836.6 | 3UTR | AAUAAUGUGUGUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | AUGUGUGUGUGUGUAUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 17 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000310836.6 | 3UTR | AAUAAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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