pre-miRNA Information
pre-miRNA hsa-mir-6818   
Genomic Coordinates chr22: 30007049 - 30007113
Description Homo sapiens miR-6818 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6818-3p
Sequence 44| UUGUCUCUUGUUCCUCACACAG |65
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1325627700 2 dbSNP
rs750902684 3 dbSNP
rs756542190 6 dbSNP
rs1365035732 17 dbSNP
Putative Targets

Gene Information
Gene Symbol CLEC4D   
Synonyms CD368, CLEC-6, CLEC6, CLECSF8, MCL, MPCL
Description C-type lectin domain family 4 member D
Transcript NM_080387   
Expression
Putative miRNA Targets on CLEC4D
3'UTR of CLEC4D
(miRNA target sites are highlighted)
>CLEC4D|NM_080387|3'UTR
   1 AAACTCAGAAAGTGGTCCTTGTGATGGAAAGAGAAAAGAAAAACCAATTAGAATAAGGCAGAATGTACGTGCGTCATTGG
  81 AACACAGAAAACATGCTGGTTCATACAGCGTTTTTAGTCATAATGGTCTTTTTTATTTTGTTTGATTCATTCGAGACAAC
 161 ATGTGTGTATGTGTGTGTGTGTGTGTGTAGATAATGTGGTTTTTGTATGGTGTTTGATGGAAGGAATAATCTTTCTTTGC
 241 TTTCTTAGTAGTATTTCAAGGTGTTTACTTTTCAATTGGTGTGCACTGAATGCATGTATGGAAGAATAGCGTGAATAATG
 321 CAATCTCTTTGTCATTTTTCCCCTTCTCAGACTCTTAGCTCTTAAAATTCAAAGATGGGATATTCTAACTGGTAGTGGTG
 401 CATCATTTTTAACCCAAATATTGCAAGCACTTTAAAGATTTGAAACCACATTTTTATTGTTTGATGTTTCATTTTCAGAC
 481 TTTTTAATGTCAGTCATTACAATTACATTGCATGAGGAAAATTTTTCCAGAACAACAGTGTGGAATAGTTCTGAATTATG
 561 CTGTTCTACAGATAGAAAAAAAGTCCAAATGCCTTTAAAAATTTACTTCTTACTCCACCCAACACGTTTTTGCAAAGCAA
 641 GAAGTCTTTGTAAGACACCTTAAACAAAGTCCTTCAATTCTACAGCAGAGGAAATAAAATCCCCCAGAAGCCAAAGGGCT
 721 CACCTTCACATTGTTAGTTCATGACAGACCCAGGTGTGCTTCATTAGAGATAACATACATTCCCTTTGGTATCACAGGAA
 801 GTTACTGGGGATTACTCGACCTCATTACTTAGCTAACGACTGGATAAAATTTCTTAATTGTTTGAAGTAACATTGTATTC
 881 GTGTTTGCATTATTAATTTGAATAGAAAATAATCACATTTTCAACCCATTTATACAAATTGTTAATGTTTCTTTAGAGCT
 961 GTATAACTATAGTTTGAACTAGCAAGGAAGTTATTGTTTTGACAACCAGAAATTATGCTTTTCTGGTGCATGAAACATTA
1041 ATTGCAAAGGGCAGTCACATCCAACTTTAATAAAATATGGTGGTCTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
1121 AAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaCACACUCCUUGUUCUCUGUu 5'
            |||||    |: |||||:| 
Target 5' agGTGTGCTTCATTAGAGATAa 3'
752 - 773 140.00 -14.64
2
miRNA  3' gacACACUCCUUGUUCUCUGUu 5'
             ||||| |:| |||||| | 
Target 5' cctTGTGATGGA-AAGAGAAAa 3'
17 - 37 138.00 -13.62
3
miRNA  3' gaCACACUCCUUGUUCUCUGUu 5'
            || |||   |:  |||||| 
Target 5' ttGTTTGATTCATTCGAGACAa 3'
138 - 159 124.00 -11.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30488395 19 COSMIC
COSN18737225 20 COSMIC
COSN30508545 41 COSMIC
COSN30118095 42 COSMIC
COSN2374924 44 COSMIC
COSN7385334 72 COSMIC
COSN31554022 73 COSMIC
COSN31489503 74 COSMIC
COSN30504528 101 COSMIC
COSN17678772 123 COSMIC
COSN20109172 135 COSMIC
COSN18736489 188 COSMIC
COSN31542169 211 COSMIC
COSN5868819 232 COSMIC
COSN30162231 262 COSMIC
COSN31960747 312 COSMIC
COSN5868820 378 COSMIC
COSN32057909 537 COSMIC
COSN9480627 625 COSMIC
COSN1591195 690 COSMIC
COSN216990 839 COSMIC
COSN17840495 977 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs966430587 4 dbSNP
rs1249493536 7 dbSNP
rs762779976 9 dbSNP
rs766257005 16 dbSNP
rs1440769215 17 dbSNP
rs756761378 18 dbSNP
rs117963676 20 dbSNP
rs1262187778 21 dbSNP
rs767169681 23 dbSNP
rs865831842 27 dbSNP
rs1177005748 30 dbSNP
rs775896537 34 dbSNP
rs1361005580 39 dbSNP
rs1460506098 41 dbSNP
rs1232740851 44 dbSNP
rs1354598675 46 dbSNP
rs1330676797 47 dbSNP
rs752298337 48 dbSNP
rs755679803 49 dbSNP
rs763480573 51 dbSNP
rs750986569 53 dbSNP
rs1335569410 54 dbSNP
rs1034871109 66 dbSNP
rs1449668338 68 dbSNP
rs1215838651 69 dbSNP
rs960789125 72 dbSNP
rs1401643347 74 dbSNP
rs773013110 75 dbSNP
rs916480843 76 dbSNP
rs1451145435 81 dbSNP
rs1388190946 85 dbSNP
rs1164656869 86 dbSNP
rs770604707 87 dbSNP
rs1372915715 89 dbSNP
rs983656517 93 dbSNP
rs1019489711 98 dbSNP
rs147470619 104 dbSNP
rs759063641 107 dbSNP
rs774858576 108 dbSNP
rs984069166 110 dbSNP
rs909863067 111 dbSNP
rs762447397 117 dbSNP
rs7307664 118 dbSNP
rs975371290 122 dbSNP
rs7138828 123 dbSNP
rs1210695546 124 dbSNP
rs11442181 129 dbSNP
rs544279143 129 dbSNP
rs375761094 153 dbSNP
rs752013111 154 dbSNP
rs1242760575 156 dbSNP
rs1491486777 161 dbSNP
rs749501338 162 dbSNP
rs1319783940 168 dbSNP
rs1156688961 170 dbSNP
rs138070495 170 dbSNP
rs377759688 170 dbSNP
rs754052295 170 dbSNP
rs922800113 170 dbSNP
rs979394804 170 dbSNP
rs934152329 172 dbSNP
rs1050046492 176 dbSNP
rs1345263541 177 dbSNP
rs1380896338 177 dbSNP
rs878882990 182 dbSNP
rs1432158590 183 dbSNP
rs1298097618 186 dbSNP
rs1476977669 187 dbSNP
rs1248531431 189 dbSNP
rs7300097 196 dbSNP
rs1010598598 197 dbSNP
rs148532747 201 dbSNP
rs1355840358 209 dbSNP
rs1354890653 210 dbSNP
rs370198198 211 dbSNP
rs1217978363 212 dbSNP
rs1347680146 213 dbSNP
rs35769706 214 dbSNP
rs1276170605 236 dbSNP
rs902149695 249 dbSNP
rs1339489529 252 dbSNP
rs999283790 258 dbSNP
rs1295941259 262 dbSNP
rs1035143438 264 dbSNP
rs60451208 276 dbSNP
rs765226375 277 dbSNP
rs767508754 278 dbSNP
rs1412702190 280 dbSNP
rs1045413280 292 dbSNP
rs1023576311 296 dbSNP
rs898401478 307 dbSNP
rs1261056567 308 dbSNP
rs780233422 310 dbSNP
rs1488699826 311 dbSNP
rs184620468 312 dbSNP
rs530304744 313 dbSNP
rs547193189 318 dbSNP
rs909894329 325 dbSNP
rs1314538257 326 dbSNP
rs1188319244 328 dbSNP
rs1279918816 328 dbSNP
rs1316779220 335 dbSNP
rs777389282 336 dbSNP
rs1236666414 343 dbSNP
rs886858051 352 dbSNP
rs1159903356 353 dbSNP
rs1408135391 377 dbSNP
rs1302113945 380 dbSNP
rs1008358338 381 dbSNP
rs6487219 387 dbSNP
rs972883345 389 dbSNP
rs1464998622 397 dbSNP
rs770516774 404 dbSNP
rs1172831615 410 dbSNP
rs1478302366 413 dbSNP
rs1413346786 429 dbSNP
rs1180523131 430 dbSNP
rs1484430927 438 dbSNP
rs6487220 443 dbSNP
rs1198606170 445 dbSNP
rs189230115 456 dbSNP
rs749551448 458 dbSNP
rs1029693322 459 dbSNP
rs1050329317 472 dbSNP
rs1318199694 484 dbSNP
rs1311542702 496 dbSNP
rs74839373 502 dbSNP
rs923910878 503 dbSNP
rs946964098 505 dbSNP
rs1043966221 509 dbSNP
rs1445967020 510 dbSNP
rs1398003779 516 dbSNP
rs780082113 531 dbSNP
rs11046028 537 dbSNP
rs1349568326 539 dbSNP
rs934982128 544 dbSNP
rs1425742253 556 dbSNP
rs917992352 559 dbSNP
rs1056250369 560 dbSNP
rs947911924 565 dbSNP
rs1200036791 567 dbSNP
rs1480685152 568 dbSNP
rs896206654 569 dbSNP
rs1218928766 570 dbSNP
rs1044895714 571 dbSNP
rs1292297696 574 dbSNP
rs1239149699 577 dbSNP
rs1374629731 580 dbSNP
rs1011975005 582 dbSNP
rs6487221 585 dbSNP
rs1367039738 586 dbSNP
rs1211500087 594 dbSNP
rs887578727 595 dbSNP
rs773789454 608 dbSNP
rs1350673384 612 dbSNP
rs1158492463 613 dbSNP
rs1046770791 615 dbSNP
rs1006099447 619 dbSNP
rs1179850259 625 dbSNP
rs1433042388 626 dbSNP
rs1007996315 627 dbSNP
rs1188932681 628 dbSNP
rs1014793192 634 dbSNP
rs1269119644 645 dbSNP
rs868322871 647 dbSNP
rs182269313 648 dbSNP
rs961395514 654 dbSNP
rs1215694947 656 dbSNP
rs1351266318 660 dbSNP
rs1041214765 666 dbSNP
rs1233056150 670 dbSNP
rs1438540885 678 dbSNP
rs1311477895 681 dbSNP
rs1299359613 682 dbSNP
rs1388589544 683 dbSNP
rs973133038 685 dbSNP
rs1029769433 688 dbSNP
rs1176177403 695 dbSNP
rs1297842461 700 dbSNP
rs1398338830 701 dbSNP
rs1362849051 704 dbSNP
rs955659926 705 dbSNP
rs1396351393 718 dbSNP
rs1376421063 724 dbSNP
rs1173388701 726 dbSNP
rs985532898 731 dbSNP
rs911399060 739 dbSNP
rs1173641403 740 dbSNP
rs1192530525 752 dbSNP
rs1487067984 766 dbSNP
rs996788627 767 dbSNP
rs946826992 771 dbSNP
rs968279829 777 dbSNP
rs1235258616 789 dbSNP
rs1324404825 793 dbSNP
rs979719130 805 dbSNP
rs1336517511 811 dbSNP
rs1330808811 818 dbSNP
rs187191229 819 dbSNP
rs1307255864 822 dbSNP
rs1319468046 828 dbSNP
rs1373246434 836 dbSNP
rs1234988109 838 dbSNP
rs1255287429 839 dbSNP
rs898204035 848 dbSNP
rs992161411 859 dbSNP
rs7976134 861 dbSNP
rs1273291850 863 dbSNP
rs1457090632 868 dbSNP
rs1193685780 872 dbSNP
rs7963287 873 dbSNP
rs1253770386 874 dbSNP
rs1202111605 878 dbSNP
rs981014693 881 dbSNP
rs896124425 882 dbSNP
rs1454317551 890 dbSNP
rs931230180 916 dbSNP
rs747462360 917 dbSNP
rs1044755297 920 dbSNP
rs866929818 923 dbSNP
rs190078012 940 dbSNP
rs1244277592 943 dbSNP
rs1339112189 945 dbSNP
rs887652770 954 dbSNP
rs908440326 969 dbSNP
rs11046036 971 dbSNP
rs1377522194 973 dbSNP
rs1400196020 973 dbSNP
rs1463580256 974 dbSNP
rs1398245668 1001 dbSNP
rs1040713005 1004 dbSNP
rs1457035704 1008 dbSNP
rs899584002 1015 dbSNP
rs996576823 1016 dbSNP
rs753979738 1017 dbSNP
rs777097465 1019 dbSNP
rs1237459193 1029 dbSNP
rs11046037 1034 dbSNP
rs73045775 1039 dbSNP
rs1273755683 1047 dbSNP
rs1209476067 1052 dbSNP
rs1030087613 1054 dbSNP
rs1267667415 1072 dbSNP
rs1247169006 1076 dbSNP
rs1376867219 1087 dbSNP
rs1307681982 1091 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084074. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000299665.2 | 3UTR | CAACAUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000299665.2 | 3UTR | AACAUGUGUGUAUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000299665.2 | 3UTR | ACAUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000299665.2 | 3UTR | CAACAUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000299665.2 | 3UTR | UCGAGACAACAUGUGUGUAUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000299665.2 | 3UTR | CAACAUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084074
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SantaCruzAb
Location of target site ENST00000299665.2 | 3UTR | CAACAUGUGUGUAUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000299665.2 | 3UTR | ACAUGUGUGUAUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000299665.2 | 3UTR | ACAUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000299665.2 | 3UTR | AACAUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000299665.2 | 3UTR | CAACAUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000299665.2 | 3UTR | AACAUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000299665.2 | 3UTR | AACAUGUGUGUAUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000299665.2 | 3UTR | AACAUGUGUGUAUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
150 hsa-miR-6818-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112122 TIMM17A translocase of inner mitochondrial membrane 17A 2 6
MIRT262243 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT446689 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT449923 TPST2 tyrosylprotein sulfotransferase 2 2 2
MIRT464356 USP12P1 ubiquitin specific peptidase 12 pseudogene 1 2 2
MIRT485703 CBX7 chromobox 7 2 2
MIRT497478 XPR1 xenotropic and polytropic retrovirus receptor 1 2 4
MIRT499435 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT514246 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT515032 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515065 PLA2G2C phospholipase A2 group IIC 2 2
MIRT520235 USP9X ubiquitin specific peptidase 9, X-linked 2 4
MIRT523685 FHL2 four and a half LIM domains 2 2 4
MIRT525524 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT525838 FAR2 fatty acyl-CoA reductase 2 2 2
MIRT528583 PTGER3 prostaglandin E receptor 3 2 2
MIRT530404 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530703 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT535118 PLSCR4 phospholipid scramblase 4 2 2
MIRT539880 IRGQ immunity related GTPase Q 2 2
MIRT540195 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540938 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541501 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT542544 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542559 ZNF280B zinc finger protein 280B 2 2
MIRT542689 RPS15A ribosomal protein S15a 2 2
MIRT548759 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT549735 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT553060 ULK1 unc-51 like autophagy activating kinase 1 2 2
MIRT556303 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT560816 DIP2A disco interacting protein 2 homolog A 2 2
MIRT567455 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT575143 Cd93 CD93 antigen 2 2
MIRT607217 ACSM2A acyl-CoA synthetase medium chain family member 2A 2 4
MIRT607286 CD300E CD300e molecule 2 6
MIRT607302 RREB1 ras responsive element binding protein 1 2 6
MIRT608645 ABCF3 ATP binding cassette subfamily F member 3 2 4
MIRT611095 MYO1F myosin IF 2 4
MIRT611576 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT614271 WSCD2 WSC domain containing 2 2 2
MIRT614855 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT617114 KANK2 KN motif and ankyrin repeat domains 2 2 2
MIRT618002 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618028 CTU1 cytosolic thiouridylase subunit 1 2 2
MIRT619062 BSND barttin CLCNK type accessory beta subunit 2 4
MIRT619289 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619356 CFHR5 complement factor H related 5 2 2
MIRT620725 CCL16 C-C motif chemokine ligand 16 2 2
MIRT620913 LRRTM2 leucine rich repeat transmembrane neuronal 2 2 2
MIRT621902 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT622025 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT622556 PTPN3 protein tyrosine phosphatase, non-receptor type 3 2 2
MIRT623137 NCKAP1 NCK associated protein 1 2 2
MIRT623140 NAV2 neuron navigator 2 2 2
MIRT623701 HHAT hedgehog acyltransferase 2 2
MIRT624602 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT625944 OLIG3 oligodendrocyte transcription factor 3 2 2
MIRT625988 SPATA17 spermatogenesis associated 17 2 2
MIRT628028 LSAMP limbic system-associated membrane protein 2 2
MIRT635521 MC2R melanocortin 2 receptor 2 2
MIRT638916 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT639796 EPX eosinophil peroxidase 2 2
MIRT640344 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT644806 VLDLR very low density lipoprotein receptor 2 2
MIRT645303 AGTRAP angiotensin II receptor associated protein 2 2
MIRT645629 SYTL4 synaptotagmin like 4 2 2
MIRT645683 TBC1D13 TBC1 domain family member 13 2 2
MIRT646216 DUSP10 dual specificity phosphatase 10 2 2
MIRT648505 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT649748 UTP20 UTP20, small subunit processome component 2 2
MIRT649797 CLEC2D C-type lectin domain family 2 member D 2 2
MIRT650482 UFM1 ubiquitin fold modifier 1 2 2
MIRT653199 SP9 Sp9 transcription factor 2 2
MIRT655741 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT659978 C2CD2L C2CD2 like 2 2
MIRT660350 BAG4 BCL2 associated athanogene 4 2 2
MIRT662185 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663290 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT666817 PRCP prolylcarboxypeptidase 2 2
MIRT671665 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT671838 PDE3A phosphodiesterase 3A 2 2
MIRT672193 F2 coagulation factor II, thrombin 2 2
MIRT673870 KLF2 Kruppel like factor 2 2 2
MIRT683563 CARD8 caspase recruitment domain family member 8 2 2
MIRT684545 ZNF708 zinc finger protein 708 2 2
MIRT685140 TACR3 tachykinin receptor 3 2 2
MIRT685413 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT686039 SLC5A5 solute carrier family 5 member 5 2 2
MIRT686126 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT687473 NHLRC2 NHL repeat containing 2 2 2
MIRT687946 HHIP hedgehog interacting protein 2 2
MIRT688171 FRRS1 ferric chelate reductase 1 2 2
MIRT688295 FAM208A family with sequence similarity 208 member A 2 2
MIRT689044 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT689194 ZNF574 zinc finger protein 574 2 2
MIRT691253 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT695358 PHAX phosphorylated adaptor for RNA export 2 2
MIRT696674 APOC3 apolipoprotein C3 2 2
MIRT697358 ZNF394 zinc finger protein 394 2 2
MIRT697604 XIAP X-linked inhibitor of apoptosis 2 2
MIRT697726 USP6NL USP6 N-terminal like 2 2
MIRT697776 UBXN7 UBX domain protein 7 2 2
MIRT698478 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT698984 SPAG9 sperm associated antigen 9 2 2
MIRT699851 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT700172 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT704339 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT704589 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT705836 AHCY adenosylhomocysteinase 2 2
MIRT707085 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT707132 TRA2B transformer 2 beta homolog 2 2
MIRT707145 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT707234 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT707347 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT707445 PPFIBP1 PPFIA binding protein 1 2 2
MIRT707494 AXL AXL receptor tyrosine kinase 2 2
MIRT707638 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT707690 FAM118A family with sequence similarity 118 member A 2 2
MIRT707706 CDC6 cell division cycle 6 2 2
MIRT707817 TMEM170A transmembrane protein 170A 2 2
MIRT707957 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT707996 NUDT4 nudix hydrolase 4 2 2
MIRT708026 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT708058 LIX1L limb and CNS expressed 1 like 2 2
MIRT708089 KIAA1671 KIAA1671 2 2
MIRT708125 GK5 glycerol kinase 5 (putative) 2 2
MIRT708194 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT708201 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT710503 BSDC1 BSD domain containing 1 2 2
MIRT711308 IFNGR2 interferon gamma receptor 2 2 2
MIRT711740 DTX1 deltex E3 ubiquitin ligase 1 2 2
MIRT713202 SOCS6 suppressor of cytokine signaling 6 2 2
MIRT714380 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT715210 NPVF neuropeptide VF precursor 2 2
MIRT715559 EPHB4 EPH receptor B4 2 2
MIRT715835 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT716680 HLA-B major histocompatibility complex, class I, B 2 2
MIRT717660 THBS2 thrombospondin 2 2 2
MIRT718132 PALM paralemmin 2 2
MIRT718322 METTL7A methyltransferase like 7A 2 2
MIRT720693 RNF217 ring finger protein 217 2 2
MIRT720727 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT721376 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721983 FAM214B family with sequence similarity 214 member B 2 2
MIRT722163 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT722881 MOB3A MOB kinase activator 3A 2 2
MIRT723218 FMNL3 formin like 3 2 2
MIRT723788 MUC17 mucin 17, cell surface associated 2 2
MIRT724093 TMEM199 transmembrane protein 199 2 2
MIRT725265 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6818-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)

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