miRTarBase - #MIRT611818


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pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol FCRL4   
Synonyms CD307d, FCRH4, IGFP2, IRTA1
Description Fc receptor like 4
Transcript NM_031282   
Expression
Putative miRNA Targets on FCRL4
3'UTR of FCRL4
(miRNA target sites are highlighted)		 
>FCRL4|NM_031282|3'UTR
   1 GAGAATGAAAAGTTACGAGAACGTCCTACTCATGTGATTTCTCCCTTGTCCAAAGTCCCAGGCCCAGTGCAGTCCTTGCG
  81 GCCCCTGGAATGATCAACTCATTCCAGCTTTCTAATTCTTCTCATGCATATGCATTCACTCCCAGGAATACTCATTCGTC
 161 TACTCTGATGTTGGGATGGAATGGCCTCTGAAAGACTTCACTAAAATGACCAGGATCCACAGTTAAGAGAAGACCCTGTA
 241 GTATTTGCTGTGGGCCTGACCTAATGTATTCCCTAGGGTCTGCTTTAGAGAAGGGGGATAAAGAGAGAGAAGGACTGTTA
 321 TGAAAAACAGAAGCACAAATTTTGGTGAATTGGGATTTGCAGAGATGAAAAAGACTGGGTGACCTGGATCTCTGCTTAAT
 401 ACATCTACAACCATTGTCTCACTGGAGACTCACTTGCATCAGTTTGTTTAACTGTGAGTGGCTGCACAGGCACTGTGCAA
 481 ACAATGAAAAGCCCCTTCACTTCTGCCTGCACAGCTTACACTGTCAGGATTCAGTTGCAGATTAAAGAACCCATCTGGAA
 561 TGGTTTACAGAGAGAGGAATTTAAAAGAGGACATCAGAAGAGCTGGAGATGCAAGCTCTAGGCTGCGCTTCCAAAAGCAA
 641 ATGATAATTATGTTAATGTCATTAGTGACAAAGATTTGCAACATTAGAGAAAAGAGACACAAATATAAAATTAAAAACTT
 721 AAGTACCAACTCTCCAAAACTAAATTTGAACTTAAAATATTAGTATAAACTCATAATAAACTCTGCCTTTAAAAAAAGAT
 801 AAATATTTCCTACGTCTGTTCACTGAAATAATTACCAACCCCTTAGCAATAAGCACTCCTTGCAGAGAGGTTTTATTCTC
 881 TAAATACCATTCCCTTCTCAAAGGAAATAAGGTTGCTTTTCTTGTAGGAACTGTGTCTTTGAGTTACTAATTAGTTTATA
 961 TGAGAATAATTCTTGCAATAAATGAAGAAGGAATAAAAGAAATAGGAAGCCACAAATTTGTATGGATATTTCATGATACA
1041 CCTACTGGTTAAATAATTGACAAAAACCAGCAGCCAAATATTAGAGGTCTCCTGATGGAAGTGTACAATACCACCTACAA
1121 ATTATCCATGCCCCAAGTGTTAAAACTGAATCCATTCAAGTCTTTCTAACTGAATACTTGTTTTATAGAAAATGCATGGA
1201 GAAAAGGAATTTGTTTAAATAACATTATGGGATTGCAACCAGCAAAACATAAACTGAGAAAAAGTTCTATAGGGCAAATC
1281 ACCTGGCTTCTATAACAAATAAATGGGAAAAAAATGAAATAAAAAGAAGAGAGGGAGGAAGAAAGGGAGAGAGAAGAAAA
1361 GAAAAATGAAGAAAAGTAATTAGAATATTTTCAACATAAAGAAAAGACGAATATTTAAGGTGACAGATATCCCAACTACG
1441 CTGATTTGATCTTTACAAATTATATGAGTGTATGAATTTGTCACATGTATCACCCCCAAAAAAAGAGAAAAAGAAAAATA
1521 GAAGACATATAAATTAAATGAGACGAGACATGTCGACCAAAAGGAATGTGTGGGTCTTGTTTGGATCCTGACTCAAATTA
1601 AGAAAAAATAAAACTACCTACGAAATACTAAGAAAAATTTGTATACTAATATTAAGAAATTGTTGTGTGTTTTGGATATA
1681 AGTGATAGTTTATTGTAGTGATGTTTTTATAAAAGCAAAAGGATATTCACTTTCAGCGCTTATACTGAAGTATTAGATTA
1761 AAGCTTATTAACGTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaUACCCACCCUGUCUCUCCc 5'
            |||| |   | ||||||| 
Target 5' gaATGGTTTACAGAGAGAGGa 3'
 558 - 578 155.00 -18.50
2 
miRNA  3' gauacccacccUGUCUCUCCc 5'
                     :|||||||| 
Target 5' aagcactccttGCAGAGAGGt 3'
 851 - 871 146.00 -13.00
3 
miRNA  3' gauacccaccCUGUCUCUCCc 5'
                    || ||||||| 
Target 5' gaaataaaaaGA-AGAGAGGg 3'
 1316 - 1335 142.00 -14.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31487317 1 COSMIC
COSN30504086 16 COSMIC
COSN30449030 17 COSMIC
COSN32055768 23 COSMIC
COSN30453797 43 COSMIC
COSN30193235 48 COSMIC
COSN13478439 57 COSMIC
COSN31505277 59 COSMIC
COSN30528552 79 COSMIC
COSN2468816 82 COSMIC
COSN30543801 88 COSMIC
COSN31522166 91 COSMIC
COSN30128925 118 COSMIC
COSN30134448 118 COSMIC
COSN28196027 179 COSMIC
COSN21686502 223 COSMIC
COSN30129928 253 COSMIC
COSN24125408 313 COSMIC
COSN9364045 728 COSMIC
COSN22879407 790 COSMIC
COSN29580246 791 COSMIC
COSN17246027 798 COSMIC
COSN29226296 1021 COSMIC
COSN26627809 1197 COSMIC
COSN32061259 1308 COSMIC
COSN25869734 1439 COSMIC
COSN26203050 1442 COSMIC
COSN21876315 1502 COSMIC
COSN17725763 1597 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs187311182 3 dbSNP
rs1426628028 6 dbSNP
rs867211538 7 dbSNP
rs61023553 16 dbSNP
rs755685686 17 dbSNP
rs370897126 22 dbSNP
rs763345321 23 dbSNP
rs759887185 24 dbSNP
rs1460579862 28 dbSNP
rs564610736 29 dbSNP
rs376162760 32 dbSNP
rs763301146 33 dbSNP
rs368978193 34 dbSNP
rs1301008674 36 dbSNP
rs540326299 37 dbSNP
rs767578026 42 dbSNP
rs765181227 44 dbSNP
rs903442907 45 dbSNP
rs1043207065 47 dbSNP
rs372875747 49 dbSNP
rs1203291286 55 dbSNP
rs911328764 56 dbSNP
rs1251216952 58 dbSNP
rs985642404 62 dbSNP
rs934161092 67 dbSNP
rs947524153 71 dbSNP
rs776494146 79 dbSNP
rs541546477 80 dbSNP
rs849827 83 dbSNP
rs542928965 84 dbSNP
rs1014526456 85 dbSNP
rs984894348 96 dbSNP
rs1177675794 98 dbSNP
rs1481659695 100 dbSNP
rs118025271 101 dbSNP
rs951821911 107 dbSNP
rs1023845695 110 dbSNP
rs1393474077 114 dbSNP
rs1235746272 123 dbSNP
rs1210233808 124 dbSNP
rs1299359062 127 dbSNP
rs1359486230 137 dbSNP
rs982853998 139 dbSNP
rs1312843957 141 dbSNP
rs1322811372 143 dbSNP
rs1012046919 147 dbSNP
rs896333009 153 dbSNP
rs1238488326 156 dbSNP
rs1034911083 157 dbSNP
rs999424631 158 dbSNP
rs1316650630 166 dbSNP
rs1485027790 176 dbSNP
rs973918068 179 dbSNP
rs1308375290 193 dbSNP
rs963850294 194 dbSNP
rs1018098997 199 dbSNP
rs1414633560 200 dbSNP
rs1476114219 210 dbSNP
rs902458554 226 dbSNP
rs1043723918 229 dbSNP
rs141219629 229 dbSNP
rs1162686949 233 dbSNP
rs1417164010 234 dbSNP
rs1007669031 235 dbSNP
rs3841012 235 dbSNP
rs1343026272 236 dbSNP
rs954948326 239 dbSNP
rs1302854473 240 dbSNP
rs1356799152 241 dbSNP
rs1310617216 243 dbSNP
rs1291941257 250 dbSNP
rs1413599691 259 dbSNP
rs1229340230 262 dbSNP
rs1375736420 265 dbSNP
rs849828 267 dbSNP
rs545588986 268 dbSNP
rs1215348702 276 dbSNP
rs756781156 278 dbSNP
rs1238327469 282 dbSNP
rs1486693635 289 dbSNP
rs889835769 293 dbSNP
rs1185951957 294 dbSNP
rs999222432 297 dbSNP
rs1344312210 305 dbSNP
rs903453891 307 dbSNP
rs1043259997 317 dbSNP
rs1050281368 321 dbSNP
rs1176323347 322 dbSNP
rs1420864681 330 dbSNP
rs1376939298 333 dbSNP
rs183069311 344 dbSNP
rs1311768030 345 dbSNP
rs922793244 350 dbSNP
rs1443567746 354 dbSNP
rs1281578431 355 dbSNP
rs1348968965 369 dbSNP
rs1223646011 387 dbSNP
rs1281270259 390 dbSNP
rs1350387543 402 dbSNP
rs1208761254 405 dbSNP
rs1279748648 406 dbSNP
rs1483305784 412 dbSNP
rs1475562406 419 dbSNP
rs938485621 435 dbSNP
rs928335680 436 dbSNP
rs1469407305 437 dbSNP
rs1191605338 440 dbSNP
rs374917926 446 dbSNP
rs1203573169 452 dbSNP
rs14335 464 dbSNP
rs1370650551 480 dbSNP
rs1261740805 484 dbSNP
rs1331454505 485 dbSNP
rs1334554581 491 dbSNP
rs1218381091 493 dbSNP
rs919861272 499 dbSNP
rs758846992 510 dbSNP
rs748060849 512 dbSNP
rs1302695219 522 dbSNP
rs1340144851 523 dbSNP
rs910160145 526 dbSNP
rs849829 533 dbSNP
rs1254660504 535 dbSNP
rs951804958 555 dbSNP
rs911089849 562 dbSNP
rs573950795 564 dbSNP
rs1390476528 566 dbSNP
rs916302538 569 dbSNP
rs149144976 574 dbSNP
rs1165703330 581 dbSNP
rs960466693 593 dbSNP
rs1034837421 603 dbSNP
rs954818844 604 dbSNP
rs1360816462 606 dbSNP
rs1397164321 610 dbSNP
rs768371478 612 dbSNP
rs1302909003 614 dbSNP
rs998879981 622 dbSNP
rs967327820 623 dbSNP
rs536127914 626 dbSNP
rs1455122575 627 dbSNP
rs749101053 632 dbSNP
rs1233836270 633 dbSNP
rs562994276 634 dbSNP
rs375310057 645 dbSNP
rs568778227 651 dbSNP
rs1261970573 665 dbSNP
rs191313938 665 dbSNP
rs1190349398 682 dbSNP
rs1372008657 687 dbSNP
rs1475342797 693 dbSNP
rs1166273626 705 dbSNP
rs1420698614 706 dbSNP
rs998207274 713 dbSNP
rs901296808 738 dbSNP
rs1385890315 741 dbSNP
rs1384136769 753 dbSNP
rs1316237993 759 dbSNP
rs906966477 762 dbSNP
rs1047230718 763 dbSNP
rs575699734 766 dbSNP
rs1295020495 770 dbSNP
rs1037155549 771 dbSNP
rs1232389460 775 dbSNP
rs1261095910 783 dbSNP
rs924818920 784 dbSNP
rs1038032456 785 dbSNP
rs1260661852 786 dbSNP
rs1485692843 793 dbSNP
rs1054492 798 dbSNP
rs1467382633 802 dbSNP
rs145600867 804 dbSNP
rs144527505 813 dbSNP
rs1049134107 814 dbSNP
rs1164612757 822 dbSNP
rs368927998 825 dbSNP
rs1364762253 839 dbSNP
rs780309346 844 dbSNP
rs1157014863 855 dbSNP
rs529376317 859 dbSNP
rs140457338 860 dbSNP
rs916213876 867 dbSNP
rs1415461244 878 dbSNP
rs1314853798 879 dbSNP
rs1353412199 880 dbSNP
rs528217666 897 dbSNP
rs1307378642 899 dbSNP
rs923398758 907 dbSNP
rs1236660243 912 dbSNP
rs1224604521 915 dbSNP
rs1325528259 921 dbSNP
rs1348175821 926 dbSNP
rs1295818038 936 dbSNP
rs560705319 941 dbSNP
rs1277617670 944 dbSNP
rs1484949932 961 dbSNP
rs1181770488 974 dbSNP
rs960435455 981 dbSNP
rs927736725 989 dbSNP
rs1383726309 991 dbSNP
rs977504774 994 dbSNP
rs1421247283 999 dbSNP
rs977878521 1005 dbSNP
rs1368464504 1011 dbSNP
rs967427800 1022 dbSNP
rs548928436 1025 dbSNP
rs530539737 1028 dbSNP
rs1021621047 1037 dbSNP
rs1373730201 1041 dbSNP
rs563923250 1044 dbSNP
rs1298645807 1062 dbSNP
rs753356466 1062 dbSNP
rs1398625825 1088 dbSNP
rs1389406117 1096 dbSNP
rs1396592754 1097 dbSNP
rs1306033804 1100 dbSNP
rs1371230431 1102 dbSNP
rs958995612 1108 dbSNP
rs1166270103 1123 dbSNP
rs1461527658 1124 dbSNP
rs976207667 1127 dbSNP
rs185970677 1130 dbSNP
rs1022185666 1132 dbSNP
rs1373882194 1137 dbSNP
rs1011260832 1162 dbSNP
rs1346480961 1168 dbSNP
rs954012937 1170 dbSNP
rs1204686162 1186 dbSNP
rs1252393068 1195 dbSNP
rs1481914134 1198 dbSNP
rs1028269401 1205 dbSNP
rs1172755487 1209 dbSNP
rs866914994 1210 dbSNP
rs901264319 1223 dbSNP
rs1452972485 1229 dbSNP
rs1195705365 1231 dbSNP
rs1393542873 1239 dbSNP
rs1034987673 1250 dbSNP
rs1374661018 1257 dbSNP
rs756339876 1259 dbSNP
rs1460434898 1260 dbSNP
rs1003063675 1264 dbSNP
rs1037080509 1265 dbSNP
rs1394918519 1266 dbSNP
rs1442884537 1267 dbSNP
rs1470268658 1269 dbSNP
rs907390337 1271 dbSNP
rs1248991186 1272 dbSNP
rs1297104174 1275 dbSNP
rs1004304200 1279 dbSNP
rs888629968 1285 dbSNP
rs182651399 1286 dbSNP
rs1025795838 1287 dbSNP
rs993950099 1294 dbSNP
rs1338117576 1300 dbSNP
rs1258032774 1305 dbSNP
rs868295793 1307 dbSNP
rs1469161054 1308 dbSNP
rs545966392 1315 dbSNP
rs898244541 1315 dbSNP
rs1251561766 1316 dbSNP
rs1048578885 1333 dbSNP
rs1421773135 1336 dbSNP
rs1426868006 1353 dbSNP
rs12116911 1356 dbSNP
rs1169838009 1361 dbSNP
rs1418573302 1368 dbSNP
rs948972282 1370 dbSNP
rs1462807683 1376 dbSNP
rs942307979 1381 dbSNP
rs1348869693 1391 dbSNP
rs1431049932 1397 dbSNP
rs533608871 1401 dbSNP
rs916197768 1403 dbSNP
rs1345485958 1405 dbSNP
rs1302492835 1408 dbSNP
rs1054791519 1409 dbSNP
rs1373166052 1417 dbSNP
rs1326716494 1421 dbSNP
rs1051429012 1422 dbSNP
rs1390927494 1424 dbSNP
rs1397224326 1426 dbSNP
rs543534201 1430 dbSNP
rs923804421 1435 dbSNP
rs861998 1436 dbSNP
rs977847422 1439 dbSNP
rs1484932435 1440 dbSNP
rs914626512 1441 dbSNP
rs945208510 1459 dbSNP
rs559945196 1461 dbSNP
rs1476148745 1463 dbSNP
rs1185480012 1469 dbSNP
rs1412827219 1485 dbSNP
rs1401122821 1487 dbSNP
rs1455835513 1489 dbSNP
rs1343136710 1492 dbSNP
rs1362590835 1507 dbSNP
rs1043121969 1509 dbSNP
rs1312969102 1526 dbSNP
rs1356620888 1536 dbSNP
rs915043194 1540 dbSNP
rs1436726820 1542 dbSNP
rs1417190230 1543 dbSNP
rs147627660 1544 dbSNP
rs1206677515 1550 dbSNP
rs2758679 1552 dbSNP
rs28408942 1554 dbSNP
rs1234781202 1556 dbSNP
rs1215900662 1558 dbSNP
rs2758680 1568 dbSNP
rs1277710973 1575 dbSNP
rs994295539 1576 dbSNP
rs1236872921 1582 dbSNP
rs537020207 1588 dbSNP
rs976681910 1589 dbSNP
rs968326785 1590 dbSNP
rs1238174843 1592 dbSNP
rs1336269599 1618 dbSNP
rs1178784762 1620 dbSNP
rs965358170 1621 dbSNP
rs576032414 1622 dbSNP
rs1004686492 1625 dbSNP
rs888567543 1631 dbSNP
rs12039602 1639 dbSNP
rs1432376998 1641 dbSNP
rs1375119039 1643 dbSNP
rs898254404 1645 dbSNP
rs1437003283 1648 dbSNP
rs1359155667 1649 dbSNP
rs1443311881 1653 dbSNP
rs538589268 1656 dbSNP
rs1006579673 1666 dbSNP
rs1470831774 1667 dbSNP
rs1239724493 1671 dbSNP
rs1304505764 1676 dbSNP
rs1366027017 1677 dbSNP
rs1350103979 1696 dbSNP
rs894677918 1698 dbSNP
rs889472577 1711 dbSNP
rs867663055 1712 dbSNP
rs1050775892 1721 dbSNP
rs553990509 1728 dbSNP
rs933941357 1730 dbSNP
rs902390538 1731 dbSNP
rs1396583241 1733 dbSNP
rs12088314 1734 dbSNP
rs1171500216 1735 dbSNP
rs1425001511 1737 dbSNP
rs534531656 1738 dbSNP
rs1331236717 1739 dbSNP
rs578126896 1740 dbSNP
rs906219585 1743 dbSNP
rs1446561230 1744 dbSNP
rs1326819023 1757 dbSNP
rs1281966028 1764 dbSNP
rs754661960 1764 dbSNP
rs1204332304 1767 dbSNP
rs1351356060 1768 dbSNP
rs1042102453 1771 dbSNP
rs763285557 1772 dbSNP
rs567325878 1773 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000271532.1 | 3UTR | AAGAGAGGGAGGAAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000271532.1 | 3UTR | AAGAGAGGGAGGAAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000271532.1 | 3UTR | AAAGAAGAGAGGGAGGAAGAAAGGGAGAGAGAAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000271532.1 | 3UTR | AGAAGAGAGGGAGGAAGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000271532.1 | 3UTR | AAGAGAGGGAGGAAGAAAGGGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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