pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KLB   
Synonyms BKL
Description klotho beta
Transcript NM_175737   
Expression
Putative miRNA Targets on KLB
3'UTR of KLB
(miRNA target sites are highlighted)
>KLB|NM_175737|3'UTR
   1 ACTGATCTGTCTGCATGATAGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGGAGATATACCTGTA
  81 TTATAGAAAGACAATCTGAGATACAGCTGTAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATTCCC
 161 TTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAAACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACA
 241 TGCTACATTGCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCTTTAGCTTTCATCTCTACCAATAGCTACTTGT
 321 GGTACAATAAATTATTTTTAAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGA
 401 GGCCGAGGCGGGGAGATCACCTGAGGTGAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGTCTCTACTAAAA
 481 ATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAACC
 561 CAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGCCTAGGCGACAACAGCAAGACTGTGTCCAAAAAA
 641 AAAAAAAAAAGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAACACCCTTCTTTAAACTGGGTAGTC
 721 AGTGATAGATAATATATATTCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCTAAAATGGAAAGAA
 801 AACACAATAGGGTAAGTAGTGCTTGTCTAAGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTTCTA
 881 ACAACAAAAAATCACCTATAGAATATCTAATTTGTGATCTTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGC
 961 CAGGCACGGTGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTTAGGAGTTCGAGA
1041 CTAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGCATGGTGGTGGGCACCTGTAAT
1121 CCCAGCTACTCAGGAGGCCGAGGCAGGAGAATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAAGATCGTGCCAT
1201 TGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCTCAAAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTTC
1281 CAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGACTCAACTCTGTGAATAGAAGTTGCTATACTGTAA
1361 GTAAAGCAACAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTTTGGGCTAGGGTTAATTACTAGAT
1441 CTGACTTGGATAATTTGACACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAAACATCTGAGGAAG
1521 AAAACTTAAATATGCACCTATTTATACCTATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTGTCC
1601 TTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCACAAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGC
1681 AGTTTTGATTATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTATCTAACTGCTAATGAACAAGTTTCCAAAATA
1761 CTGTAAAAATACAATTAGTCAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGCTATTTGGCCTGGCAAATGGGA
1841 ACAGTAAAATTCTGCTTTACTCTTCTCTAGTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGCAGTTTTGAGGT
1921 ATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCCCTCTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCAA
2001 TTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAAACAATCACTTGGCTGGGTTTTTTCCCCTTTGTG
2081 CCACATTGATTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGGGCAACTCATTAACCTCTCTTTAA
2161 CATCAAGGGCTTGGGAAAAAAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCTTTCAGGTTTTGCT
2241 TTCTCTTTCTCACTTTGTTTAAAGTATCTCGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAGAGC
2321 TTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGTTTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGT
2401 ACTGAGAGTCCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTTAAGCCATCATCGCACAAGAATCCAAAAACCC
2481 TTAAATTTTTTAACCACTGGCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGGCTCATGCTCTATCATACTAAA
2561 TATTCAGGTTTATCATAAACTCCTTAAAAACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGGAGCAAACAGGT
2641 AAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTGTGAAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACCT
2721 GGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGTACAGTGTGACTACATGTTTAATTTTCAATGTAA
2801 TTTATTCCAAATAAACTGGTTCATGCTGACCACTTGTATTCAACTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            |||  |||   |||||||| 
Target 5' ccCAA--GAACTCCAGGGAAAa 3'
2100 - 2119 156.00 -15.40
2
miRNA  3' cggUUCCCUUACCGUCCCUUUa 5'
             :|||  : |||:||||:| 
Target 5' tggGAGGCCGAGGCGGGGAGAt 3'
396 - 417 131.00 -23.00
3
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            ||||||  |    |||||| 
Target 5' atCAAGGGCTT----GGGAAAa 3'
2162 - 2179 129.00 -15.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30501534 15 COSMIC
COSN30523672 22 COSMIC
COSN30191681 42 COSMIC
COSN30447290 48 COSMIC
COSN30145238 61 COSMIC
COSN30503244 61 COSMIC
COSN508919 104 COSMIC
COSN20099951 853 COSMIC
COSN24342401 1254 COSMIC
COSN7490113 1268 COSMIC
COSN6830301 1299 COSMIC
COSN2027992 1364 COSMIC
COSN29528212 1648 COSMIC
COSN9040061 1666 COSMIC
COSN29669482 1783 COSMIC
COSN6830302 1977 COSMIC
COSN20099954 2190 COSMIC
COSN22978304 2447 COSMIC
COSN32055613 2789 COSMIC
COSN9789933 2842 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs929582587 5 dbSNP
rs763758863 6 dbSNP
rs530647446 7 dbSNP
rs755955313 11 dbSNP
rs780840373 16 dbSNP
rs1424347947 20 dbSNP
rs761942574 20 dbSNP
rs770117219 20 dbSNP
rs377571125 22 dbSNP
rs907257661 24 dbSNP
rs1248866412 27 dbSNP
rs780364678 30 dbSNP
rs1232457537 33 dbSNP
rs1213374814 35 dbSNP
rs550664546 37 dbSNP
rs749842132 40 dbSNP
rs769136954 41 dbSNP
rs1246107277 49 dbSNP
rs770793277 50 dbSNP
rs1044547117 56 dbSNP
rs1393959788 67 dbSNP
rs907283573 67 dbSNP
rs1002925156 70 dbSNP
rs528929988 74 dbSNP
rs1320808547 79 dbSNP
rs887764304 80 dbSNP
rs55780789 85 dbSNP
rs1006175291 87 dbSNP
rs1409193865 91 dbSNP
rs1458002014 93 dbSNP
rs1372402819 94 dbSNP
rs1017518038 97 dbSNP
rs112327399 98 dbSNP
rs139319166 115 dbSNP
rs1030506456 119 dbSNP
rs1011472336 124 dbSNP
rs1443423899 129 dbSNP
rs1269508258 130 dbSNP
rs190158547 137 dbSNP
rs1480377248 152 dbSNP
rs1250117927 155 dbSNP
rs977800707 159 dbSNP
rs1343237788 163 dbSNP
rs1303151132 170 dbSNP
rs1233055185 171 dbSNP
rs924986034 172 dbSNP
rs953937790 175 dbSNP
rs1386831103 178 dbSNP
rs957699840 185 dbSNP
rs990811704 186 dbSNP
rs1007156823 189 dbSNP
rs1231143618 190 dbSNP
rs1172816161 194 dbSNP
rs1452386313 201 dbSNP
rs1019406667 222 dbSNP
rs948914774 232 dbSNP
rs1418577094 235 dbSNP
rs150001094 238 dbSNP
rs1248518013 239 dbSNP
rs535734443 251 dbSNP
rs1207849836 255 dbSNP
rs965511985 257 dbSNP
rs981610641 258 dbSNP
rs928770677 260 dbSNP
rs1209144824 269 dbSNP
rs1347645649 278 dbSNP
rs145214710 289 dbSNP
rs1047835206 292 dbSNP
rs1334597915 295 dbSNP
rs776588049 297 dbSNP
rs952342505 307 dbSNP
rs1411544641 310 dbSNP
rs749319051 311 dbSNP
rs80311857 313 dbSNP
rs1404173695 319 dbSNP
rs182394633 323 dbSNP
rs1469832203 326 dbSNP
rs116491942 331 dbSNP
rs539724692 337 dbSNP
rs997774784 340 dbSNP
rs551435142 349 dbSNP
rs1186508923 354 dbSNP
rs1444423514 363 dbSNP
rs1030186324 365 dbSNP
rs1200627706 377 dbSNP
rs1349545030 384 dbSNP
rs1470051938 386 dbSNP
rs547573864 398 dbSNP
rs1044964868 402 dbSNP
rs999272883 405 dbSNP
rs928810505 406 dbSNP
rs1292598723 410 dbSNP
rs774498874 411 dbSNP
rs1194652781 412 dbSNP
rs1053192276 416 dbSNP
rs2168844 423 dbSNP
rs113048381 427 dbSNP
rs185578891 429 dbSNP
rs1043016896 432 dbSNP
rs889705158 437 dbSNP
rs970359547 438 dbSNP
rs982088739 442 dbSNP
rs1417255266 451 dbSNP
rs1163332743 453 dbSNP
rs1474071035 456 dbSNP
rs189298216 457 dbSNP
rs1192884482 472 dbSNP
rs1394023032 484 dbSNP
rs1445688809 485 dbSNP
rs1385201360 492 dbSNP
rs929458096 493 dbSNP
rs1320393070 496 dbSNP
rs1210281315 501 dbSNP
rs1327058883 505 dbSNP
rs1019902288 507 dbSNP
rs1430647060 517 dbSNP
rs965220927 522 dbSNP
rs528394202 525 dbSNP
rs180932636 534 dbSNP
rs2608826 539 dbSNP
rs942037928 545 dbSNP
rs530763166 547 dbSNP
rs550774795 551 dbSNP
rs116352953 555 dbSNP
rs1436104221 556 dbSNP
rs750525394 562 dbSNP
rs1445854169 564 dbSNP
rs756179501 565 dbSNP
rs1191439345 566 dbSNP
rs916216310 568 dbSNP
rs970748829 572 dbSNP
rs1167906762 584 dbSNP
rs1259515492 589 dbSNP
rs1392425975 592 dbSNP
rs980376441 593 dbSNP
rs1251793491 594 dbSNP
rs1051632183 597 dbSNP
rs1218710365 606 dbSNP
rs115158956 614 dbSNP
rs1456611936 615 dbSNP
rs114178491 617 dbSNP
rs1299570338 628 dbSNP
rs999282756 631 dbSNP
rs1370484137 633 dbSNP
rs1491498762 633 dbSNP
rs1491323996 634 dbSNP
rs1169662062 635 dbSNP
rs1174818834 635 dbSNP
rs1428400395 635 dbSNP
rs1454142805 635 dbSNP
rs1491445099 635 dbSNP
rs35648143 635 dbSNP
rs55764144 635 dbSNP
rs66853070 635 dbSNP
rs1357877516 636 dbSNP
rs1394084092 651 dbSNP
rs1415832487 651 dbSNP
rs1293090198 652 dbSNP
rs1189160482 655 dbSNP
rs1339037484 659 dbSNP
rs928820915 661 dbSNP
rs1246797469 664 dbSNP
rs893535245 667 dbSNP
rs374794663 669 dbSNP
rs1012391169 672 dbSNP
rs879157425 675 dbSNP
rs1349403446 676 dbSNP
rs1213820650 679 dbSNP
rs1023329116 687 dbSNP
rs879096262 690 dbSNP
rs1485946426 691 dbSNP
rs1053668599 692 dbSNP
rs1352840861 694 dbSNP
rs913338291 702 dbSNP
rs947437950 705 dbSNP
rs1253821915 707 dbSNP
rs1035904413 712 dbSNP
rs185599606 718 dbSNP
rs1173443256 732 dbSNP
rs1415840943 734 dbSNP
rs1425205529 739 dbSNP
rs1176093140 758 dbSNP
rs1471351668 761 dbSNP
rs1184320741 767 dbSNP
rs1182894379 779 dbSNP
rs1364591489 781 dbSNP
rs546585834 791 dbSNP
rs1212452814 793 dbSNP
rs1156904455 799 dbSNP
rs1313034961 809 dbSNP
rs983588942 811 dbSNP
rs909314003 812 dbSNP
rs1435922160 819 dbSNP
rs566298230 820 dbSNP
rs1007240444 822 dbSNP
rs1352475027 838 dbSNP
rs1289447661 841 dbSNP
rs1414721655 847 dbSNP
rs200595463 848 dbSNP
rs865879375 848 dbSNP
rs1304992758 849 dbSNP
rs1158038881 851 dbSNP
rs34261066 851 dbSNP
rs1455183656 852 dbSNP
rs1413539818 856 dbSNP
rs975217889 859 dbSNP
rs921997085 863 dbSNP
rs1040953558 868 dbSNP
rs901054406 875 dbSNP
rs1307347142 880 dbSNP
rs1483484978 886 dbSNP
rs1241737668 889 dbSNP
rs1375658297 898 dbSNP
rs1237389977 900 dbSNP
rs994032265 902 dbSNP
rs1331248290 903 dbSNP
rs1233166705 904 dbSNP
rs79236630 904 dbSNP
rs888205240 906 dbSNP
rs1315495216 907 dbSNP
rs1229234137 910 dbSNP
rs1361781667 918 dbSNP
rs1210093715 919 dbSNP
rs535077449 925 dbSNP
rs1023344306 927 dbSNP
rs1481529555 933 dbSNP
rs1196122851 936 dbSNP
rs1390142654 937 dbSNP
rs969063702 946 dbSNP
rs980792126 949 dbSNP
rs1457008041 950 dbSNP
rs555749714 958 dbSNP
rs1289960551 959 dbSNP
rs1389331345 968 dbSNP
rs569191524 968 dbSNP
rs755426595 969 dbSNP
rs1248922359 977 dbSNP
rs1213120779 978 dbSNP
rs1487578973 987 dbSNP
rs779485232 988 dbSNP
rs947509676 992 dbSNP
rs1246172425 993 dbSNP
rs1307221708 995 dbSNP
rs1295894595 998 dbSNP
rs978814491 1000 dbSNP
rs1225682880 1002 dbSNP
rs1366881923 1003 dbSNP
rs1454724329 1004 dbSNP
rs1176055094 1012 dbSNP
rs1053575085 1016 dbSNP
rs911240862 1018 dbSNP
rs942728715 1022 dbSNP
rs1012033551 1023 dbSNP
rs1295153748 1026 dbSNP
rs1045211926 1027 dbSNP
rs1369671663 1033 dbSNP
rs1041418274 1038 dbSNP
rs901090224 1043 dbSNP
rs1399961663 1044 dbSNP
rs929848444 1045 dbSNP
rs1327429944 1052 dbSNP
rs1431445355 1056 dbSNP
rs1003175200 1057 dbSNP
rs1046964909 1059 dbSNP
rs1483034271 1076 dbSNP
rs1218124104 1083 dbSNP
rs1273158985 1085 dbSNP
rs888277247 1086 dbSNP
rs1207717611 1096 dbSNP
rs1299152477 1097 dbSNP
rs1274910090 1103 dbSNP
rs553606080 1104 dbSNP
rs1328796498 1106 dbSNP
rs1302802873 1107 dbSNP
rs1023377055 1113 dbSNP
rs904912699 1120 dbSNP
rs1306165656 1137 dbSNP
rs1370945701 1140 dbSNP
rs555902595 1140 dbSNP
rs1035059667 1141 dbSNP
rs960330308 1142 dbSNP
rs1250577547 1143 dbSNP
rs552530013 1145 dbSNP
rs1197002321 1148 dbSNP
rs989016388 1152 dbSNP
rs1255114592 1154 dbSNP
rs1020451588 1155 dbSNP
rs968843608 1161 dbSNP
rs1190654409 1163 dbSNP
rs1185063297 1164 dbSNP
rs530068905 1165 dbSNP
rs963878648 1169 dbSNP
rs974859513 1170 dbSNP
rs777516514 1172 dbSNP
rs577753946 1180 dbSNP
rs1419989187 1183 dbSNP
rs1257441320 1184 dbSNP
rs1223576840 1186 dbSNP
rs746544553 1188 dbSNP
rs1286308224 1195 dbSNP
rs1423368877 1202 dbSNP
rs1464379399 1211 dbSNP
rs942737394 1212 dbSNP
rs190153626 1219 dbSNP
rs1404592784 1230 dbSNP
rs976786899 1231 dbSNP
rs1456775942 1233 dbSNP
rs868837467 1234 dbSNP
rs1409859770 1238 dbSNP
rs1394722825 1239 dbSNP
rs1161936858 1244 dbSNP
rs987409986 1244 dbSNP
rs922586022 1245 dbSNP
rs1185836780 1247 dbSNP
rs1203908210 1251 dbSNP
rs929916274 1251 dbSNP
rs1053623932 1252 dbSNP
rs1363396783 1253 dbSNP
rs137896556 1254 dbSNP
rs145759953 1254 dbSNP
rs3068651 1254 dbSNP
rs1242327883 1257 dbSNP
rs145592175 1257 dbSNP
rs28498899 1260 dbSNP
rs888310491 1261 dbSNP
rs941188731 1262 dbSNP
rs915117889 1264 dbSNP
rs1386488820 1269 dbSNP
rs1434669770 1269 dbSNP
rs1322600597 1270 dbSNP
rs201117826 1270 dbSNP
rs534427367 1270 dbSNP
rs1413684900 1272 dbSNP
rs1162044434 1274 dbSNP
rs147643000 1286 dbSNP
rs1369423468 1290 dbSNP
rs906244816 1292 dbSNP
rs904944138 1301 dbSNP
rs1183770938 1311 dbSNP
rs1003672430 1324 dbSNP
rs573920311 1331 dbSNP
rs201087133 1335 dbSNP
rs892125376 1342 dbSNP
rs775994169 1344 dbSNP
rs1322531799 1347 dbSNP
rs760102416 1348 dbSNP
rs1358137080 1354 dbSNP
rs181382783 1358 dbSNP
rs1010469759 1362 dbSNP
rs1227440716 1383 dbSNP
rs1363257583 1383 dbSNP
rs76708393 1384 dbSNP
rs1486855553 1386 dbSNP
rs1187674483 1394 dbSNP
rs575608434 1406 dbSNP
rs1000320636 1410 dbSNP
rs1391866741 1413 dbSNP
rs1168308444 1414 dbSNP
rs996721777 1422 dbSNP
rs1018823358 1426 dbSNP
rs954983399 1428 dbSNP
rs1475451690 1436 dbSNP
rs1245679667 1443 dbSNP
rs1263097410 1447 dbSNP
rs1453217976 1453 dbSNP
rs987503313 1456 dbSNP
rs1477068968 1460 dbSNP
rs1277034455 1469 dbSNP
rs62307970 1470 dbSNP
rs1418962087 1475 dbSNP
rs564233574 1475 dbSNP
rs977238297 1476 dbSNP
rs922651938 1484 dbSNP
rs1404427334 1486 dbSNP
rs1273196767 1487 dbSNP
rs867935889 1488 dbSNP
rs2249177 1493 dbSNP
rs780339834 1511 dbSNP
rs1307974337 1513 dbSNP
rs1428142731 1516 dbSNP
rs1453841855 1519 dbSNP
rs1372861616 1520 dbSNP
rs1172066012 1527 dbSNP
rs1410227956 1551 dbSNP
rs982752909 1554 dbSNP
rs1424073904 1555 dbSNP
rs947924824 1557 dbSNP
rs142222963 1559 dbSNP
rs1269431574 1565 dbSNP
rs1338300891 1565 dbSNP
rs1481943918 1568 dbSNP
rs941219966 1569 dbSNP
rs939110671 1578 dbSNP
rs1311785746 1581 dbSNP
rs1276798808 1582 dbSNP
rs1044913369 1587 dbSNP
rs886778388 1590 dbSNP
rs1324375317 1594 dbSNP
rs560109973 1603 dbSNP
rs939155984 1612 dbSNP
rs1408596562 1616 dbSNP
rs1395572071 1617 dbSNP
rs1310829690 1622 dbSNP
rs1352686169 1625 dbSNP
rs1318880966 1626 dbSNP
rs1299066708 1632 dbSNP
rs1447795555 1634 dbSNP
rs1037972534 1635 dbSNP
rs899391214 1641 dbSNP
rs996424825 1641 dbSNP
rs1487605319 1643 dbSNP
rs766993921 1647 dbSNP
rs1213592323 1648 dbSNP
rs1414133958 1650 dbSNP
rs1258657085 1652 dbSNP
rs186928937 1654 dbSNP
rs892184892 1656 dbSNP
rs1235878124 1668 dbSNP
rs1179818776 1679 dbSNP
rs1461813968 1688 dbSNP
rs890616434 1699 dbSNP
rs1227058322 1705 dbSNP
rs767758205 1710 dbSNP
rs1308360901 1720 dbSNP
rs1228042968 1727 dbSNP
rs1300701881 1731 dbSNP
rs1377527307 1731 dbSNP
rs1419197637 1737 dbSNP
rs572163671 1738 dbSNP
rs1008976824 1742 dbSNP
rs1031005551 1749 dbSNP
rs1358019192 1755 dbSNP
rs1346835270 1756 dbSNP
rs1159748585 1766 dbSNP
rs191773820 1771 dbSNP
rs1313342699 1773 dbSNP
rs1358419779 1775 dbSNP
rs1185626810 1777 dbSNP
rs1445507423 1777 dbSNP
rs1247670911 1783 dbSNP
rs904790561 1787 dbSNP
rs989858262 1792 dbSNP
rs1466315692 1796 dbSNP
rs1445534482 1800 dbSNP
rs1282683797 1801 dbSNP
rs1022229792 1803 dbSNP
rs1320270501 1815 dbSNP
rs13112140 1819 dbSNP
rs1247212692 1829 dbSNP
rs1241079551 1833 dbSNP
rs1018483157 1837 dbSNP
rs1308657524 1848 dbSNP
rs554780500 1850 dbSNP
rs964541774 1856 dbSNP
rs980698570 1865 dbSNP
rs760683773 1868 dbSNP
rs1237156653 1873 dbSNP
rs1289359852 1876 dbSNP
rs998309051 1879 dbSNP
rs1030174444 1880 dbSNP
rs145997294 1886 dbSNP
rs753856894 1888 dbSNP
rs1442275891 1889 dbSNP
rs1165190669 1896 dbSNP
rs909851008 1908 dbSNP
rs941026443 1911 dbSNP
rs879025682 1912 dbSNP
rs962655252 1915 dbSNP
rs1186986563 1921 dbSNP
rs528966815 1924 dbSNP
rs1191093918 1931 dbSNP
rs1487768931 1933 dbSNP
rs747492253 1936 dbSNP
rs1223609738 1939 dbSNP
rs148237196 1943 dbSNP
rs551565790 1945 dbSNP
rs1177578142 1958 dbSNP
rs140228825 1962 dbSNP
rs1377955166 1965 dbSNP
rs183859671 1967 dbSNP
rs1455151774 1968 dbSNP
rs1174256435 1976 dbSNP
rs554011354 1982 dbSNP
rs1295719058 1984 dbSNP
rs9995998 1985 dbSNP
rs1050698458 1991 dbSNP
rs890626335 1991 dbSNP
rs1056274418 2007 dbSNP
rs1369786772 2011 dbSNP
rs1166925771 2013 dbSNP
rs1463760620 2015 dbSNP
rs1008985122 2016 dbSNP
rs578125569 2017 dbSNP
rs1431525039 2022 dbSNP
rs1271599701 2025 dbSNP
rs536298431 2033 dbSNP
rs1200859647 2039 dbSNP
rs945093005 2042 dbSNP
rs1482925323 2046 dbSNP
rs1250122628 2051 dbSNP
rs1043404623 2064 dbSNP
rs1193683821 2065 dbSNP
rs1251549628 2065 dbSNP
rs1340983742 2065 dbSNP
rs765815154 2074 dbSNP
rs936289649 2077 dbSNP
rs556589722 2084 dbSNP
rs892527841 2086 dbSNP
rs1285102868 2092 dbSNP
rs1354855062 2095 dbSNP
rs753130941 2096 dbSNP
rs1305911980 2111 dbSNP
rs1447796838 2113 dbSNP
rs1010972716 2114 dbSNP
rs1330863185 2115 dbSNP
rs1022744633 2117 dbSNP
rs80236142 2123 dbSNP
rs1464606067 2124 dbSNP
rs2687968 2127 dbSNP
rs998779363 2129 dbSNP
rs1443194773 2131 dbSNP
rs544472801 2134 dbSNP
rs1438762769 2136 dbSNP
rs188802912 2137 dbSNP
rs1276006698 2161 dbSNP
rs1250796979 2166 dbSNP
rs1344903419 2168 dbSNP
rs13119661 2171 dbSNP
rs753515471 2173 dbSNP
rs1328328608 2174 dbSNP
rs1402908692 2175 dbSNP
rs1217533699 2176 dbSNP
rs1300447848 2176 dbSNP
rs1387011187 2176 dbSNP
rs368300399 2176 dbSNP
rs3832280 2176 dbSNP
rs72109716 2176 dbSNP
rs1275590641 2177 dbSNP
rs1368306527 2190 dbSNP
rs1470712132 2190 dbSNP
rs1312753150 2191 dbSNP
rs1318959180 2193 dbSNP
rs2687969 2194 dbSNP
rs189571791 2197 dbSNP
rs960544605 2205 dbSNP
rs1235972609 2209 dbSNP
rs1469449405 2216 dbSNP
rs982591479 2219 dbSNP
rs367912237 2222 dbSNP
rs1206886489 2224 dbSNP
rs1351100138 2225 dbSNP
rs1198925668 2232 dbSNP
rs1245574352 2239 dbSNP
rs774139581 2242 dbSNP
rs1316006478 2244 dbSNP
rs1169505612 2245 dbSNP
rs1363193325 2252 dbSNP
rs1320827145 2254 dbSNP
rs1390684690 2257 dbSNP
rs560016704 2257 dbSNP
rs1161776442 2259 dbSNP
rs1004293031 2266 dbSNP
rs1016987712 2267 dbSNP
rs908359839 2268 dbSNP
rs1170321850 2271 dbSNP
rs528978143 2272 dbSNP
rs1448334599 2275 dbSNP
rs1463127146 2276 dbSNP
rs1239909198 2280 dbSNP
rs1195199669 2285 dbSNP
rs980744474 2287 dbSNP
rs1324311781 2288 dbSNP
rs1447466580 2288 dbSNP
rs1330554927 2290 dbSNP
rs1219901084 2304 dbSNP
rs1034030167 2305 dbSNP
rs1361330896 2306 dbSNP
rs1292767380 2321 dbSNP
rs962806210 2325 dbSNP
rs114961058 2334 dbSNP
rs562102271 2336 dbSNP
rs992407250 2342 dbSNP
rs1330972490 2343 dbSNP
rs1341589632 2343 dbSNP
rs182267196 2347 dbSNP
rs1366641643 2352 dbSNP
rs778673438 2355 dbSNP
rs756859862 2357 dbSNP
rs1428748676 2362 dbSNP
rs1416985083 2368 dbSNP
rs748280175 2372 dbSNP
rs1169088314 2376 dbSNP
rs1259513946 2376 dbSNP
rs1475461370 2378 dbSNP
rs1245984594 2391 dbSNP
rs551627083 2396 dbSNP
rs1051126683 2400 dbSNP
rs1490773771 2402 dbSNP
rs945166800 2403 dbSNP
rs1269389076 2404 dbSNP
rs912115825 2404 dbSNP
rs979131395 2405 dbSNP
rs924977855 2407 dbSNP
rs1052574758 2414 dbSNP
rs1215170451 2415 dbSNP
rs943042604 2417 dbSNP
rs892620114 2418 dbSNP
rs571896802 2421 dbSNP
rs534158697 2429 dbSNP
rs1307765010 2430 dbSNP
rs900086347 2433 dbSNP
rs1352343290 2434 dbSNP
rs1288528721 2436 dbSNP
rs1043814487 2439 dbSNP
rs1449313127 2442 dbSNP
rs2687970 2449 dbSNP
rs1174145224 2451 dbSNP
rs1481356540 2459 dbSNP
rs1263812961 2460 dbSNP
rs567697264 2462 dbSNP
rs1181118383 2464 dbSNP
rs777968301 2472 dbSNP
rs1479538526 2477 dbSNP
rs745351087 2484 dbSNP
rs1441893350 2485 dbSNP
rs1261382735 2486 dbSNP
rs1034955226 2487 dbSNP
rs1191213149 2491 dbSNP
rs1419704935 2495 dbSNP
rs1324836574 2499 dbSNP
rs887272370 2505 dbSNP
rs1222352864 2506 dbSNP
rs1004325601 2508 dbSNP
rs1390126744 2512 dbSNP
rs536711905 2523 dbSNP
rs769794598 2527 dbSNP
rs1404946620 2529 dbSNP
rs1004121338 2533 dbSNP
rs1470678203 2533 dbSNP
rs370815936 2539 dbSNP
rs1361707545 2545 dbSNP
rs1033649387 2555 dbSNP
rs960940484 2556 dbSNP
rs186779568 2557 dbSNP
rs1472568371 2558 dbSNP
rs747300911 2559 dbSNP
rs1357679780 2568 dbSNP
rs1241555246 2569 dbSNP
rs1205572747 2577 dbSNP
rs920990007 2581 dbSNP
rs1245080119 2597 dbSNP
rs953856138 2601 dbSNP
rs992084555 2606 dbSNP
rs1319077288 2609 dbSNP
rs1206354865 2615 dbSNP
rs138791201 2616 dbSNP
rs1487936995 2617 dbSNP
rs548462106 2620 dbSNP
rs1381516129 2622 dbSNP
rs986405377 2625 dbSNP
rs140719049 2628 dbSNP
rs111608435 2629 dbSNP
rs1288195356 2633 dbSNP
rs1451590929 2635 dbSNP
rs2687971 2639 dbSNP
rs1368113571 2640 dbSNP
rs1471878403 2654 dbSNP
rs1160551458 2658 dbSNP
rs558119028 2672 dbSNP
rs1261186120 2674 dbSNP
rs768382277 2676 dbSNP
rs150317679 2678 dbSNP
rs1487111002 2679 dbSNP
rs974822406 2684 dbSNP
rs922955363 2686 dbSNP
rs1296825397 2691 dbSNP
rs934276846 2692 dbSNP
rs946863793 2695 dbSNP
rs540099839 2700 dbSNP
rs137955097 2701 dbSNP
rs1247781964 2710 dbSNP
rs1359497719 2712 dbSNP
rs1294183394 2713 dbSNP
rs1380050390 2713 dbSNP
rs1404874610 2717 dbSNP
rs1289376052 2718 dbSNP
rs1363544546 2723 dbSNP
rs1396966494 2725 dbSNP
rs777102792 2729 dbSNP
rs1425498584 2733 dbSNP
rs908741431 2735 dbSNP
rs1168345369 2736 dbSNP
rs142341973 2738 dbSNP
rs542266876 2739 dbSNP
rs1352255914 2740 dbSNP
rs145927092 2745 dbSNP
rs1199403110 2751 dbSNP
rs1237890926 2752 dbSNP
rs1489955940 2754 dbSNP
rs1271551187 2759 dbSNP
rs531171572 2765 dbSNP
rs1223727359 2767 dbSNP
rs139018573 2771 dbSNP
rs774118508 2773 dbSNP
rs1224526685 2774 dbSNP
rs1056509287 2776 dbSNP
rs1483494777 2776 dbSNP
rs896467346 2779 dbSNP
rs1222874461 2780 dbSNP
rs1199640687 2781 dbSNP
rs1304680030 2784 dbSNP
rs896480343 2786 dbSNP
rs866244853 2788 dbSNP
rs1395963100 2789 dbSNP
rs1004171952 2794 dbSNP
rs1463579522 2797 dbSNP
rs1013484330 2798 dbSNP
rs1176299139 2801 dbSNP
rs1479718842 2802 dbSNP
rs1253755171 2807 dbSNP
rs1015481636 2816 dbSNP
rs1200524874 2819 dbSNP
rs1440937598 2825 dbSNP
rs898331650 2828 dbSNP
rs1193772304 2837 dbSNP
rs1180666044 2841 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' -------------uuGGGAAAa 3'
1 - 9
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000257408.4 | 3UTR | UUGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000257408.4 | 3UTR | UUGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000257408.4 | 3UTR | CUUGGGAAAAAAAAAAAAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000257408.4 | 3UTR | UUGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000257408.4 | 3UTR | AAGGGCUUGGGAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000257408.4 | 3UTR | UUGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000257408.4 | 3UTR | CAAGGGCUUGGGAAAAAAAAAAAAAAGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000257408.4 | 3UTR | UUGGGAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000257408.4 | 3UTR | UUGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

Error report submission