miRTarBase - #MIRT613356


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pre-miRNA Information
pre-miRNA hsa-mir-155   
Genomic Coordinates chr21: 25573980 - 25574044
Description Homo sapiens miR-155 stem-loop
Comment Human mir-155 is predicted based on homology to a cloned miR from mouse (MIR:MI0000177) .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-155-3p
Sequence 43| CUCCUACAUAUUAGCAUUAACA |64
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1181188719 6 dbSNP
rs759895287 7 dbSNP
rs200351615 8 dbSNP
rs377265631 10 dbSNP
rs1038360714 20 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA4I1F miR-155 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Blood and urinary supernatants Quantitative real-time PCR
BA4I1F miR-155 Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Kidney tissue Quantitative real-time PCR
Gene Information
Gene Symbol ADAMTS5   
Synonyms ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2
Description ADAM metallopeptidase with thrombospondin type 1 motif 5
Transcript NM_007038   
Expression
Putative miRNA Targets on ADAMTS5
3'UTR of ADAMTS5
(miRNA target sites are highlighted)		 
>ADAMTS5|NM_007038|3'UTR
   1 CCTGTGGTTATGATCTTATGCACAAAGATAACTGGAGGATTCAGCACTGATGCAGTCGTGGTGAACAGGAGGTCTACCTA
  81 ACGCACAGAAAGTCATGCTTCAGTGACATTGTCAACAGGAGTCCAATTATGGGCAGAATCTGCTCTCTGTGACCAAAAGA
 161 GGATGTGCACTGCTTCACGTGACAGTGGTGACCTTGCAATATAGAAAAACTTGGGAGTTATTGAACATCCCCTGGGCTTA
 241 CAAGAAACACTGATGAATGTAAAATCAGGGGACATTTGAAGATGGCAGAACTGTCTCCCCCTTGTCACCTACCTCTGATA
 321 GAATGTCTTTAATGGTATCATAATCATTTTCACCCATAATACACAGTAGCTTCTTCTTACTGTTTGTAAATACATTCTCC
 401 CTTGGTATGTCACTTTATATCCCCTGGTTCTATTAAAATATCCATATATATTTCTATAAAAAAAGTGTTTGACCAAAGTA
 481 GGTCTGCAGCTATTTCAACTTCCTTCCGTTTCCAGAAAGAGCTGTGGATATTTTACTGGAAATTAAGAACTTGCTGCTGT
 561 TTTAATAAGATGTAGTATATTTTCTGACTACAGGAGATAAAATTTCAGTCAAAAAACCATTTTGACAGCAAGTATCTTCT
 641 GAGAAATTTTGAAAAGTAAATAGATCTCAGTGTATCTAGTCACTTAAATACATACACGGGTTCATTTACTTAAACCTTTG
 721 ACTGCCTGTATTTTTTTCAGGTAGCTAGCCAAATTAATGCATAATTTCAGATGTAGAAGTAGGGTTTGCGTGTGTGTGTG
 801 TGATCATACTCAAGAGTCTAAAAACTAGTTTCCTTGTGTTGGAAATTTAAAAGGAAAAAAATCGTATTTCACTGTGTTTT
 881 CAATTTATATTTTCACAACTACTTTCTCTCTCCAGAGCTTTCATCTGATATCTCACAATGTATGATATACGTACAAAACA
 961 CACAGCAAGTTTTCTATCATGTCCAACACATTCAACACTGGTATACCTCCTACCAGCAAGCCTTTAAAATGCATTTGTGT
1041 TTGCTTATTTGTTTTGTTCAAGGGTTCAGTAAGACCTACAATGTTTTGTATTTCTTGACTTATTTTATTAGAAACATTAA
1121 AGATCACTTGGTAGTTAGCCACATTGAGAAGTGGTTATCATTGTTAATGTGGTTAATGCCAAAAAGTGGTTAATATTAAT
1201 AAGACTGTTTCCACACCATAGGCAATAATTTCTTAATTTAAAAAATCTAAGTATATTCCTATTGTACTAAATATTTTTCC
1281 CAACTGGAAAGCACTTGATTGTACCCGTAAGTGTTTGAGTGATGACATGTGATGATTTTCAGAAAGTTGTTGTTTTTGTT
1361 TCCATAGCCTGTTTAAGTAGGTTGTAAGTTTGAATAGTTAGACATGGAAATTATTTTATAAGCACACACCTAAAGATATC
1441 TTTTTAGATGATAAAATGTACACCCCCCCATCACCAACCTCACAACTTAGAAAATCTAAGTTGTTTGATTTCTTTGGGAT
1521 TTCTTTTGTTGTGAAACACTGCAAAGCCAATTTTTCTTTATAAAAATTCATAGTAATCCTGCCAAATGTGCCTATTGTTA
1601 AAGATTTGCATGTGAAGATCTTAGGGAACCACTGTTTGAGTTCTACAAGCTCATGAGAGTTTATTTTTATTATAAGATGT
1681 TTTTAATATAAAAGAATTATGTAACTGATCACTATATTACATCATTTCAGTGGGCCAGGAAAATAGATGTCTTGCTGTTT
1761 TCAGTATTTTCTTAAGAAATTGCTTTTAAAACAAATAATTGTTTTACAAAACCAATAATTATCCTTTGAATTTTCATAGA
1841 CTGACTTTGCTTTTGACGTAGAAATTTTTTTTCTCAATAAATTATCACTTTGAGAAATGAGGCCTGTACAAGGCTGATAA
1921 CCTATATGTGATGGAGATCACCCAATGCCAAGGGCAGAAAGCAAACCTAGTTAAATAGGTGAGAAAAAAAATAATAATCC
2001 CAGTGCCATTTGTCTGTGCAAAGAGAATTAGGAGAGAGGTTAATGTTACTTTTTTCCATTTTGGAAATAATTTTAATCAA
2081 GTAACTCAAATGTGACAAAATTTATTTTTATTTTTTGTGGTTATATTCCCAACAACATTAAAAAATACTCGAGGCATAAA
2161 TGTAGTTGTCTCCTACTCTGCTTCTCTTACTATACTCATACATTTTTAATATGGTTTATCAATGATTCATGTTTCCCTCA
2241 AATAGTGATGGTTTACACCTGTCATGGAAACAATCCTAGAGAGCTCAGAGCAATTAAACCACTATTCCATGCTTTTAAGT
2321 AGTTTTCTCCACCTTTTTCTTATGAGTCTCACTAGATTGACTGAGGAATGTATGTCTAAATTCCTGGAGAAGATGATATG
2401 GATTGGAAACTGAAATTCAGAGAAATGGAGTGTTCAATAGATACCACGAATTGTGAACAAAGGGAAAATTCTATACAACT
2481 CAATCTAAGTCAGTCCACTTTGACTTCGTACTGTCTTTCACCTTTCCATTGTTGCATCTTGAATTTTTTAAAATGTCTAG
2561 AATTCAGGATGCTAGGGGCTACTTCTTTAAAAAAAAAAAAAAAAAAGAATTCGTCTGAAAATGCTCAGGTTTGTAAGAAT
2641 CTAATCTCACTTACATAACTAAGCACTCCATAATAAGTTTTATTAAGTACAAAGGGAGCCAGAAAAAATGACATTTATTT
2721 CTTCTAGATCAGAAAAATTTAAATTAAGCCCTGCCTTGCTGTTTAGAAATATGTGGGCATTGTTATAATTTATTCAATAA
2801 ATTTATGTTCCTTTGCCTTCCTGTGGAAACAGTTTTATCCCACTAAACTAGGAATTAGGGGATAAATCACAAACAAAAAA
2881 AAAGTTGCAGCACTGAAAAAAAGTAATTTATTGTTTTTGCAACTGGTATGTGAATTTGTGTGATAAAATTATTTATTCTT
2961 ATTTAACAAAAATATGTTCAAATTTTTCTATATTTAAAATGTTTTGCTGTTGTCCTACTTTTTAATTTATGCTTCATGTT
3041 TGTGTATAAAGTACACTTTTACACTTTGTGAGTTTACATAATATACAGCACTGGTTGCTTTTGTATTTTTTTACAGAAAG
3121 CTTTCTGTGTGAAGCAGGTGTATATGTATATATTCCTCATGTATTCTTATTCTGATACTATCATTTTTCTTTCCAAGGAA
3201 ATTTTAATCTGTCATGACCAATAGTGTTCATTACTTGTGCCTATGATAATAGGTTTTTTACATCACATTAACACTATTTT
3281 TTCCAAGTCACAAATAAGAAAAACACTTATTCAATGAAACAAGGTGCAAGTTTTAAATTTGGGTACACAAATAGCCTAGA
3361 AGCTTCCTACAGACGCTAAGACACAGCCAATAATCAGATCCTTTCACTTCATCGAGAAACTTGGACAAGTCGATATTGAT
3441 GTATTAGATGAAAGTTGTCTACACACAACTTCTGAGGGATACAAACGATAATAAAACCAAATGTTGTCTGTTTCTCCTTT
3521 AGAAACACCTCCTAAAATTAATATCATTTAGTCTCTAGTGTCTGTAGGATTCTACAGATGAGCACAAATAGATTGGGTTT
3601 GTATAACAAATGCTAATAGTCATAACTGTTTCTACAAATATGGGGTGTCCATTAAGAGAATGTGATGTTTTCCTACTGCT
3681 GTTGAATCCCATGGGGTGATTATAGGACTTGAAATAGGCAGAGTCACCTCTGATGACATCAGCTTGCCTCTGTGATTTCA
3761 CAGTCTGATCCTGGCAACAAGACAAAGCACCCTTGGACACACAGCCAATCTCTGGTTGTGATATTTCCCCATTGATTCCT
3841 TCCTTGTTAACAAGGTCATTTTAATGGTTCAGGTGAGGACAGCAGCCAGATTCAAAGTCCAGAATTTGTGCTGTTACATA
3921 GAGTTCACACTGTCAAATAACATTGAATTTAATAATGATCAAATTTTTCTAGTAGTCTTTGGCAGAGTGTATAATCTCAT
4001 TGGCATGATTGGTGAATATTACTAATCTCTTTATAATGAAAGATGCTTTACAAATACCTTATATTTGCTAACATTTCAAA
4081 ACTACTAAATAAATGAAATAGCCATGTGTACAGAAATGGTCATTTAAAGCTTTAATAGAACCAAATTCAAGACAATGTAT
4161 CATTTAGACACACAGAAAAGGAACTTGTATGTTTTCCCTATTATTTTTCTCATTTGCCAACAATCTATAGTTTTAGGTTA
4241 TCAAACAGATAGATCAACTTAACTGGCTAGTACATTGAAAAATCTTCCTAAGAATCCTTTGTTAGCATAATCTATAGAGA
4321 TAATTTCTCAAATTATATCATCATGATGCATATAAACTCTATAATGTATAATTGTGTTTCATTTATTTAATGTATGAGAA
4401 CATATTGAAATACAAAACCATGCATTAGCCAAAAAATTGGAATACAGGTAGTGTTCAGATCAGCAAAACATTCAGTCTGG
4481 TAAATGCCTGCCTGGGGCTATGATATCATTCTCAATGCAGGTTTTATGGAAAAACTAAAAGAATATGTTGTTAGATGATG
4561 TTGGTTTTGAAAAAAAAAAGACATTAACATACACATTAGTTAGCCCAGTTAATTGCATTCTACTAATATAGTTGCACATT
4641 AGCAATAATTTTGCTGTCTCTGGTCTTTATTTTGTGGCTTCAACTAACTGGACCATGTGGACTGTAAAGGTCAAATGGAA
4721 AAAACGAGCAGTGGCCCCTCATCCTGTAAGGTACTGCTACATCAGAGTGACCTAAAAGTCTAACACTGTGAGGAAAACTG
4801 TGATTTGTAGGAAAAAAAAAAAAAACAAATAAAAAACAGGGCATGCTTTTTAATTTTTTTCCACTTTCCTTTGGCACACC
4881 CAATGAACAATTCTAATTTTTATTGAGGTGCTAACATCTTTCGTGACCGACTGTCAAATGTGGTATTTTTGAGTTACTAT
4961 TTTTCTACATGATTTTACAGTTTGCAAGAAAGACCTCTAAGCTTTGTGTCACGGTAGGGCACAACTTGATACTCAAAATT
5041 TGAAAAATAAGCACATCCAATGATTGTTTTGACCAACAGTGGTCAGTGACGTAAACTGCATGTGCATCTGAGGACATTTA
5121 AGGGGTCATTAAAATTTGAGGAGCATCAGGCCGGAGTAGCAGACTTTTAGATGAGTCATATTTCAGCATTCACTAAGTCC
5201 TCAGCATTCCATTCAAACTGTCGTGTATATTTGGCCTGATTTTTTTTCAAGCTTTGCAATAATTTATGTTATTGGTAAAC
5281 ACTTGGTGACTATATCTCAGCCTTTTCTTTAACAACTCACAATATATTAGAAACACGTCTACCTATACTGAGAGTATATT
5361 TACAATAGAAGAACATACTGTATGTGACTTTGTAAAGCTAGACTTTTGATTAAGAAATATATAATCTCTGGATGCTATTT
5441 TTGCATTATACACTCAGGCACAACGTAAACCTTGATGGCTCATCTTGCTACAATTACGAGTTGAAAAACACTACTTACGT
5521 ATTTGTATGACCTATTAGTCAGAGGAAATCATACATATGCTTTGTAAATAGACTTTGCAGATAACTAAATAGACTGAAGA
5601 AATATGTTGCATTTGATAGAAGCAATTGCATAAATATTTGGTTTCTATATTAGAGTCTGTGAGTAAAGTCAAGTAATAAA
5681 CCTAAGTAGGTATAACAGATTTTTAAACCTTGAAACTTGCTTTGATGGTAGAGAAAATCATTGAAGATTTACATACTGTA
5761 TATAAGATGTAAAATGTACGCTGCTTATTACCCTCAATTTTCCAGAAGCAATGGTATATAATGCAGTTGAAAAACCAAAA
5841 ATCTTGGAAAACTAAGACGGGTCTTGTTTAAAATGTCTCTCAGCTTTGGCAACCTTCAAATCTTAATCAACTATTTAAAG
5921 CATTACTGTGTCTTGTAGCCTGCATTCCACAACAGCTCTGTTATTCAGGTAAAAGACTTGAACTGAGCCGTTTGGGACCT
6001 ATACTGTAATATTTTCATTGAGGAACAATATCCTATTTTGTAAAGCATTTCCCTATGTGTGACTTTAAACTGTAAAATTA
6081 AACACTGCTTTTGTGGGTTCAGTGGGCATAATAAATATAAATTGTAAACTAGGTTAAAGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acAAUUA-CGAUUAU--ACAUCCUc 5'
            |||:|  |||:|:  ||||||| 
Target 5' atTTAGTCTCTAGTGTCTGTAGGAt 3'
 3546 - 3570 162.00 -11.70
2 
miRNA  3' acaaUUACGAUUAUACAUCCUc 5'
              | || |:|| ||||||| 
Target 5' gaaaACTG-TGATTTGTAGGAa 3'
 4793 - 4813 157.00 -9.50
3 
miRNA  3' acAAUUACG-AUUA-----UACAUCCUc 5'
            ||||||| ||||     |||||| | 
Target 5' aaTTAATGCATAATTTCAGATGTAGAAg 3'
 752 - 779 144.00 -12.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30110784 1 COSMIC
COSN30151980 6 COSMIC
COSN30692313 6 COSMIC
COSN30146430 12 COSMIC
COSN506811 16 COSMIC
COSN30479168 23 COSMIC
COSN30182177 44 COSMIC
COSN20080019 47 COSMIC
COSN28632853 48 COSMIC
COSN13878590 49 COSMIC
COSN16274101 82 COSMIC
COSN24382362 83 COSMIC
COSN31579052 85 COSMIC
COSN31604494 123 COSMIC
COSN30176131 161 COSMIC
COSN28733039 184 COSMIC
COSN2488736 193 COSMIC
COSN16738484 223 COSMIC
COSN28802356 237 COSMIC
COSN31550750 250 COSMIC
COSN7142425 259 COSMIC
COSN31961909 353 COSMIC
COSN31584797 397 COSMIC
COSN31573088 486 COSMIC
COSN31537440 487 COSMIC
COSN24307260 491 COSMIC
COSN31584573 547 COSMIC
COSN1888837 579 COSMIC
COSN20116791 711 COSMIC
COSN28039797 750 COSMIC
COSN22488797 864 COSMIC
COSN31483875 1178 COSMIC
COSN31570575 1212 COSMIC
COSN31520639 1228 COSMIC
COSN1888836 1250 COSMIC
COSN23820500 1258 COSMIC
COSN30241857 1306 COSMIC
COSN5451609 1331 COSMIC
COSN7142424 1397 COSMIC
COSN7142423 1514 COSMIC
COSN8903026 1524 COSMIC
COSN9155167 1617 COSMIC
COSN7142422 1624 COSMIC
COSN32063100 1674 COSMIC
COSN1888835 1939 COSMIC
COSN31548976 2224 COSMIC
COSN8611618 2237 COSMIC
COSN26633919 2282 COSMIC
COSN28639879 2395 COSMIC
COSN20116786 2588 COSMIC
COSN20116789 2589 COSMIC
COSN32057112 2638 COSMIC
COSN31529732 2702 COSMIC
COSN31568106 2766 COSMIC
COSN186287 2782 COSMIC
COSN31541619 2810 COSMIC
COSN31538667 2874 COSMIC
COSN5451608 2934 COSMIC
COSN31529723 2946 COSMIC
COSN17807960 2967 COSMIC
COSN31588177 3008 COSMIC
COSN31531204 3030 COSMIC
COSN4783157 3054 COSMIC
COSN31596509 3079 COSMIC
COSN9155166 3127 COSMIC
COSN26330093 3138 COSMIC
COSN9155165 3286 COSMIC
COSN24958470 3335 COSMIC
COSN32056661 3348 COSMIC
COSN24525194 4049 COSMIC
COSN16081155 4259 COSMIC
COSN16368580 4421 COSMIC
COSN28160276 4422 COSMIC
COSN18723552 4568 COSMIC
COSN20116781 4569 COSMIC
COSN1255310 4570 COSMIC
COSN32100727 4635 COSMIC
COSN31959834 4702 COSMIC
COSN18843181 4811 COSMIC
COSN27519406 4811 COSMIC
COSN8565105 4828 COSMIC
COSN27910178 4898 COSMIC
COSN8903025 4987 COSMIC
COSN17235221 5012 COSMIC
COSN4973028 5026 COSMIC
COSN28402194 5223 COSMIC
COSN25476198 5242 COSMIC
COSN25603882 5479 COSMIC
COSN31656926 5536 COSMIC
COSN1888834 5573 COSMIC
COSN25359770 5574 COSMIC
COSN5983942 5680 COSMIC
COSN31606690 5707 COSMIC
COSN18862643 6052 COSMIC
COSN7142421 6067 COSMIC
COSN25210083 6122 COSMIC
rs2830581 2572 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs368402576 9 dbSNP
rs764856112 10 dbSNP
rs753535346 14 dbSNP
rs777370374 15 dbSNP
rs764800244 19 dbSNP
rs752226589 20 dbSNP
rs1028058844 21 dbSNP
rs766994517 22 dbSNP
rs759394326 23 dbSNP
rs1446614855 26 dbSNP
rs996334915 27 dbSNP
rs751508752 37 dbSNP
rs1183043205 38 dbSNP
rs1240457297 43 dbSNP
rs1442923063 44 dbSNP
rs151065 48 dbSNP
rs377563737 49 dbSNP
rs370761737 51 dbSNP
rs75758943 57 dbSNP
rs891808331 58 dbSNP
rs1053506900 66 dbSNP
rs1434704328 67 dbSNP
rs1325630503 73 dbSNP
rs1366253304 81 dbSNP
rs935999195 82 dbSNP
rs3746837 83 dbSNP
rs1034272749 84 dbSNP
rs769112279 91 dbSNP
rs1291871513 97 dbSNP
rs866362629 106 dbSNP
rs1449768998 107 dbSNP
rs1212880797 108 dbSNP
rs557621661 111 dbSNP
rs138760524 119 dbSNP
rs749677254 122 dbSNP
rs1372007396 140 dbSNP
rs939891386 145 dbSNP
rs1164365563 154 dbSNP
rs1416655406 173 dbSNP
rs117283492 179 dbSNP
rs984221650 182 dbSNP
rs1234068165 185 dbSNP
rs1349953486 186 dbSNP
rs1437551615 194 dbSNP
rs1318734681 201 dbSNP
rs2008402 204 dbSNP
rs1027022944 205 dbSNP
rs995634436 209 dbSNP
rs530157538 223 dbSNP
rs1286522253 226 dbSNP
rs1232588435 229 dbSNP
rs111329078 231 dbSNP
rs229078 237 dbSNP
rs1028530231 238 dbSNP
rs1039943712 242 dbSNP
rs566091449 244 dbSNP
rs1041806343 248 dbSNP
rs1189070577 259 dbSNP
rs1235243140 263 dbSNP
rs964854000 269 dbSNP
rs1019040687 270 dbSNP
rs1474548086 271 dbSNP
rs1164767061 273 dbSNP
rs1413197160 282 dbSNP
rs1292765453 288 dbSNP
rs1157167580 292 dbSNP
rs1384571046 298 dbSNP
rs1415251164 300 dbSNP
rs1009120740 301 dbSNP
rs1338715389 319 dbSNP
rs892068621 323 dbSNP
rs187870773 327 dbSNP
rs1396336399 335 dbSNP
rs1352122785 337 dbSNP
rs1000641170 352 dbSNP
rs1259901663 353 dbSNP
rs777444160 356 dbSNP
rs1345366140 361 dbSNP
rs1201809423 377 dbSNP
rs904520742 388 dbSNP
rs1044501733 394 dbSNP
rs1485034167 397 dbSNP
rs1187889632 399 dbSNP
rs948750739 400 dbSNP
rs895665839 401 dbSNP
rs1057010766 426 dbSNP
rs1385171710 430 dbSNP
rs184502688 432 dbSNP
rs939821150 441 dbSNP
rs908488895 444 dbSNP
rs937165572 446 dbSNP
rs1373744118 452 dbSNP
rs1434135745 455 dbSNP
rs984052519 457 dbSNP
rs1409206183 463 dbSNP
rs1183323338 473 dbSNP
rs930973299 483 dbSNP
rs567491780 486 dbSNP
rs927083627 502 dbSNP
rs114117451 507 dbSNP
rs530638327 508 dbSNP
rs965073695 509 dbSNP
rs1205298341 514 dbSNP
rs192726341 526 dbSNP
rs1276145754 532 dbSNP
rs1484355303 534 dbSNP
rs1194525246 537 dbSNP
rs1250262111 544 dbSNP
rs1434082967 545 dbSNP
rs1201309931 547 dbSNP
rs983226707 559 dbSNP
rs1453969077 564 dbSNP
rs1169385349 575 dbSNP
rs1487716687 577 dbSNP
rs1275367521 600 dbSNP
rs1019306043 603 dbSNP
rs551070126 604 dbSNP
rs1297472626 607 dbSNP
rs987629543 609 dbSNP
rs1388347007 612 dbSNP
rs1027034389 614 dbSNP
rs1369870522 620 dbSNP
rs528128620 634 dbSNP
rs1299193258 640 dbSNP
rs956226683 647 dbSNP
rs1018880694 661 dbSNP
rs187440668 665 dbSNP
rs891407000 678 dbSNP
rs375131448 681 dbSNP
rs1000413380 683 dbSNP
rs1300524129 685 dbSNP
rs1468253317 687 dbSNP
rs1041972497 691 dbSNP
rs781254943 691 dbSNP
rs1009911369 692 dbSNP
rs1426773167 694 dbSNP
rs112955042 697 dbSNP
rs1459372984 698 dbSNP
rs1373002984 700 dbSNP
rs374202103 701 dbSNP
rs201967272 715 dbSNP
rs372136375 715 dbSNP
rs386394504 715 dbSNP
rs71331596 715 dbSNP
rs937051010 716 dbSNP
rs1322089139 720 dbSNP
rs1022943934 730 dbSNP
rs927011799 740 dbSNP
rs1046006725 745 dbSNP
rs1453879932 750 dbSNP
rs949910789 761 dbSNP
rs1322922902 765 dbSNP
rs1013025208 770 dbSNP
rs573564228 772 dbSNP
rs183349722 779 dbSNP
rs751566555 782 dbSNP
rs1175982187 784 dbSNP
rs1057229474 789 dbSNP
rs79997650 790 dbSNP
rs1186068043 794 dbSNP
rs1401094240 800 dbSNP
rs964123224 802 dbSNP
rs1008853019 803 dbSNP
rs1018353637 803 dbSNP
rs377472990 803 dbSNP
rs1457528700 806 dbSNP
rs1161078525 809 dbSNP
rs1343113946 810 dbSNP
rs1452601887 814 dbSNP
rs1255344019 815 dbSNP
rs1380638469 817 dbSNP
rs1194626437 818 dbSNP
rs780372247 820 dbSNP
rs1259949615 827 dbSNP
rs1229436795 833 dbSNP
rs8132272 842 dbSNP
rs1315409438 843 dbSNP
rs1215256894 852 dbSNP
rs1020966244 853 dbSNP
rs931215566 863 dbSNP
rs558345591 864 dbSNP
rs1256780229 867 dbSNP
rs1472860860 870 dbSNP
rs1184160593 872 dbSNP
rs1255487689 874 dbSNP
rs1418162887 878 dbSNP
rs1176255644 893 dbSNP
rs1010464239 895 dbSNP
rs535129350 897 dbSNP
rs1039367100 901 dbSNP
rs1303932323 906 dbSNP
rs943694885 917 dbSNP
rs1362709384 919 dbSNP
rs892825774 926 dbSNP
rs1032702986 932 dbSNP
rs1001189112 933 dbSNP
rs912348380 936 dbSNP
rs1350294669 940 dbSNP
rs905646834 941 dbSNP
rs750593876 942 dbSNP
rs1319892691 947 dbSNP
rs140877085 950 dbSNP
rs191038659 951 dbSNP
rs949931161 958 dbSNP
rs1433450544 964 dbSNP
rs1480166009 969 dbSNP
rs956409283 973 dbSNP
rs924770270 974 dbSNP
rs1452177689 976 dbSNP
rs886244567 986 dbSNP
rs187477249 987 dbSNP
rs570013135 988 dbSNP
rs1174767030 989 dbSNP
rs1449263368 990 dbSNP
rs868349710 995 dbSNP
rs1331413034 1001 dbSNP
rs1048123195 1003 dbSNP
rs968975330 1007 dbSNP
rs550614873 1011 dbSNP
rs536905255 1013 dbSNP
rs182881823 1032 dbSNP
rs229077 1033 dbSNP
rs1447789857 1041 dbSNP
rs1302786347 1050 dbSNP
rs1012954922 1051 dbSNP
rs191048456 1056 dbSNP
rs1255617404 1060 dbSNP
rs1270745525 1068 dbSNP
rs1306829664 1077 dbSNP
rs1208779480 1078 dbSNP
rs920496842 1081 dbSNP
rs758365481 1082 dbSNP
rs879469996 1088 dbSNP
rs1248139306 1096 dbSNP
rs1204280967 1097 dbSNP
rs1339808407 1117 dbSNP
rs1035779750 1118 dbSNP
rs1271710892 1121 dbSNP
rs942702266 1122 dbSNP
rs911300996 1124 dbSNP
rs1004264036 1127 dbSNP
rs1166001332 1131 dbSNP
rs1020428399 1136 dbSNP
rs375030163 1138 dbSNP
rs886952287 1144 dbSNP
rs1325430816 1146 dbSNP
rs1339484094 1148 dbSNP
rs1433046277 1152 dbSNP
rs1268465082 1153 dbSNP
rs1310002480 1155 dbSNP
rs559216019 1159 dbSNP
rs1274816376 1160 dbSNP
rs1332353390 1163 dbSNP
rs995727069 1163 dbSNP
rs1212705106 1171 dbSNP
rs899791091 1185 dbSNP
rs549039031 1188 dbSNP
rs1190481946 1190 dbSNP
rs56273208 1191 dbSNP
rs1475382187 1194 dbSNP
rs1189188416 1203 dbSNP
rs1420517429 1215 dbSNP
rs563261510 1219 dbSNP
rs912192854 1236 dbSNP
rs1164635552 1241 dbSNP
rs1169989660 1245 dbSNP
rs1052621937 1248 dbSNP
rs1316324760 1253 dbSNP
rs1325859514 1255 dbSNP
rs935067582 1256 dbSNP
rs1294997515 1261 dbSNP
rs905493645 1263 dbSNP
rs1024488073 1265 dbSNP
rs1288743582 1266 dbSNP
rs1352469730 1269 dbSNP
rs765059687 1271 dbSNP
rs1282950445 1272 dbSNP
rs1186018992 1277 dbSNP
rs1442455496 1290 dbSNP
rs544137512 1297 dbSNP
rs1013981714 1301 dbSNP
rs1474497365 1306 dbSNP
rs924793482 1307 dbSNP
rs1471280726 1309 dbSNP
rs780084480 1313 dbSNP
rs528612611 1323 dbSNP
rs1435995003 1324 dbSNP
rs1314793445 1325 dbSNP
rs1373629773 1327 dbSNP
rs759247935 1329 dbSNP
rs1274915087 1333 dbSNP
rs1196122811 1343 dbSNP
rs1355324592 1350 dbSNP
rs969282633 1351 dbSNP
rs1308425707 1355 dbSNP
rs1337241326 1357 dbSNP
rs1236473066 1365 dbSNP
rs916204888 1370 dbSNP
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rs991700093 1377 dbSNP
rs186300576 1384 dbSNP
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rs1484982640 1428 dbSNP
rs1210706596 1429 dbSNP
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rs1004722248 1439 dbSNP
rs951517631 1440 dbSNP
rs1180077379 1444 dbSNP
rs769444246 1446 dbSNP
rs1027470827 1448 dbSNP
rs1363479802 1449 dbSNP
rs995387561 1453 dbSNP
rs899675994 1462 dbSNP
rs1039600906 1463 dbSNP
rs181934706 1465 dbSNP
rs1434033512 1468 dbSNP
rs1298642290 1470 dbSNP
rs571261048 1470 dbSNP
rs115596608 1473 dbSNP
rs1052084013 1474 dbSNP
rs576366546 1477 dbSNP
rs1163056383 1478 dbSNP
rs1300626707 1479 dbSNP
rs1346464150 1484 dbSNP
rs903634825 1499 dbSNP
rs1043863561 1507 dbSNP
rs1342046366 1510 dbSNP
rs229076 1513 dbSNP
rs1418738194 1514 dbSNP
rs1158491538 1516 dbSNP
rs1469085607 1524 dbSNP
rs1468569636 1528 dbSNP
rs1234558636 1529 dbSNP
rs1251250861 1531 dbSNP
rs916047789 1538 dbSNP
rs989014382 1540 dbSNP
rs991750730 1546 dbSNP
rs938889375 1554 dbSNP
rs1250906341 1568 dbSNP
rs1460402629 1570 dbSNP
rs957485145 1571 dbSNP
rs1394878779 1576 dbSNP
rs1033268605 1579 dbSNP
rs1323416006 1584 dbSNP
rs1369757528 1586 dbSNP
rs928851058 1597 dbSNP
rs1297091135 1602 dbSNP
rs980318431 1603 dbSNP
rs982830408 1609 dbSNP
rs951452351 1623 dbSNP
rs1023996757 1624 dbSNP
rs1215814916 1628 dbSNP
rs1014323735 1643 dbSNP
rs772548072 1649 dbSNP
rs1352155210 1657 dbSNP
rs1426679328 1660 dbSNP
rs1192326244 1678 dbSNP
rs539442132 1689 dbSNP
rs571248698 1694 dbSNP
rs1026016242 1710 dbSNP
rs769494558 1723 dbSNP
rs974526472 1734 dbSNP
rs1443481464 1735 dbSNP
rs1393360019 1739 dbSNP
rs898970598 1747 dbSNP
rs963856046 1749 dbSNP
rs191129060 1753 dbSNP
rs890352695 1758 dbSNP
rs1051133267 1761 dbSNP
rs1356638035 1762 dbSNP
rs1235578232 1769 dbSNP
rs534543603 1785 dbSNP
rs1395455830 1791 dbSNP
rs891066995 1804 dbSNP
rs1216701658 1805 dbSNP
rs769163493 1819 dbSNP
rs1484903778 1821 dbSNP
rs1204605985 1827 dbSNP
rs565837654 1836 dbSNP
rs1031323799 1838 dbSNP
rs1053158313 1850 dbSNP
rs229075 1854 dbSNP
rs115292701 1857 dbSNP
rs770799163 1858 dbSNP
rs1477650784 1859 dbSNP
rs460495 1861 dbSNP
rs980656450 1863 dbSNP
rs1195237246 1873 dbSNP
rs1376667368 1873 dbSNP
rs229074 1875 dbSNP
rs1378820902 1878 dbSNP
rs532951790 1883 dbSNP
rs1450328487 1888 dbSNP
rs947757177 1898 dbSNP
rs1224560517 1899 dbSNP
rs917481799 1904 dbSNP
rs1239597360 1906 dbSNP
rs992545254 1910 dbSNP
rs564807594 1914 dbSNP
rs775970194 1916 dbSNP
rs1213143998 1917 dbSNP
rs1448230014 1921 dbSNP
rs950394037 1923 dbSNP
rs1026029309 1924 dbSNP
rs1178704517 1931 dbSNP
rs1405394844 1933 dbSNP
rs1418148314 1934 dbSNP
rs1173786355 1939 dbSNP
rs1396305699 1945 dbSNP
rs994517613 1946 dbSNP
rs374367470 1948 dbSNP
rs1055995551 1966 dbSNP
rs1443450509 1976 dbSNP
rs963200838 1979 dbSNP
rs1371538769 1980 dbSNP
rs1446235461 1981 dbSNP
rs185825244 1985 dbSNP
rs1350082641 1989 dbSNP
rs1232029862 1991 dbSNP
rs1007794458 1992 dbSNP
rs1307982274 1992 dbSNP
rs1230956218 1999 dbSNP
rs890414982 2003 dbSNP
rs938817682 2005 dbSNP
rs143537582 2013 dbSNP
rs998204081 2016 dbSNP
rs1452079235 2019 dbSNP
rs983437444 2023 dbSNP
rs746192404 2031 dbSNP
rs1425158875 2034 dbSNP
rs1411014586 2036 dbSNP
rs541958927 2045 dbSNP
rs919889367 2048 dbSNP
rs974144258 2074 dbSNP
rs964074722 2079 dbSNP
rs1428810315 2080 dbSNP
rs1373429281 2082 dbSNP
rs1438864141 2085 dbSNP
rs56297631 2104 dbSNP
rs1362655009 2111 dbSNP
rs986626239 2119 dbSNP
rs1270634190 2120 dbSNP
rs556229975 2130 dbSNP
rs926014305 2133 dbSNP
rs1274720733 2137 dbSNP
rs1044603127 2140 dbSNP
rs1413879854 2143 dbSNP
rs955204720 2150 dbSNP
rs545826388 2151 dbSNP
rs576803897 2158 dbSNP
rs1477722070 2161 dbSNP
rs55646475 2171 dbSNP
rs903529934 2174 dbSNP
rs1175388167 2186 dbSNP
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rs1322976358 2195 dbSNP
rs530783104 2195 dbSNP
rs1184483279 2197 dbSNP
rs1432830336 2207 dbSNP
rs865951056 2212 dbSNP
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rs986022961 2241 dbSNP
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rs1208813893 2246 dbSNP
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rs1030260060 2250 dbSNP
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rs754852310 2299 dbSNP
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rs370870627 2689 dbSNP
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rs1353521515 5053 dbSNP
rs1042615993 5054 dbSNP
rs779077420 5056 dbSNP
rs892658916 5069 dbSNP
rs540326008 5074 dbSNP
rs371904062 5081 dbSNP
rs554640556 5082 dbSNP
rs927655807 5089 dbSNP
rs1204145182 5090 dbSNP
rs926899520 5091 dbSNP
rs146077595 5094 dbSNP
rs1181212148 5097 dbSNP
rs961144794 5099 dbSNP
rs868834688 5100 dbSNP
rs1444506043 5103 dbSNP
rs1159654393 5116 dbSNP
rs138256738 5118 dbSNP
rs1452035404 5125 dbSNP
rs1423773653 5126 dbSNP
rs949420843 5135 dbSNP
rs192118061 5141 dbSNP
rs1288559653 5144 dbSNP
rs917881374 5146 dbSNP
rs1163541194 5148 dbSNP
rs972192056 5150 dbSNP
rs962462833 5152 dbSNP
rs367662468 5153 dbSNP
rs755909447 5155 dbSNP
rs538914871 5161 dbSNP
rs9979684 5162 dbSNP
rs1240720702 5168 dbSNP
rs375606048 5179 dbSNP
rs553246449 5185 dbSNP
rs1238047552 5200 dbSNP
rs1184046842 5208 dbSNP
rs1256293523 5210 dbSNP
rs780850738 5222 dbSNP
rs2830580 5223 dbSNP
rs146296592 5225 dbSNP
rs188271922 5233 dbSNP
rs370147286 5234 dbSNP
rs79944253 5239 dbSNP
rs75732015 5240 dbSNP
rs751087132 5256 dbSNP
rs1158824782 5262 dbSNP
rs1378424110 5266 dbSNP
rs1471044790 5273 dbSNP
rs892924209 5282 dbSNP
rs941462354 5288 dbSNP
rs1054201184 5291 dbSNP
rs1232777882 5292 dbSNP
rs902600107 5300 dbSNP
rs1390610684 5301 dbSNP
rs1301651388 5305 dbSNP
rs551070422 5316 dbSNP
rs1221265738 5317 dbSNP
rs1262092135 5319 dbSNP
rs1318056367 5324 dbSNP
rs905326569 5334 dbSNP
rs541774281 5336 dbSNP
rs949644418 5337 dbSNP
rs1372416943 5340 dbSNP
rs184120242 5345 dbSNP
rs1176999351 5350 dbSNP
rs1268433102 5354 dbSNP
rs1296215538 5357 dbSNP
rs1481559869 5368 dbSNP
rs191921967 5375 dbSNP
rs229071 5376 dbSNP
rs1324742902 5380 dbSNP
rs1459425429 5392 dbSNP
rs1369622677 5395 dbSNP
rs1172541083 5406 dbSNP
rs1352702508 5409 dbSNP
rs1461379701 5410 dbSNP
rs9977266 5414 dbSNP
rs1293928427 5418 dbSNP
rs1347211392 5420 dbSNP
rs1167600009 5422 dbSNP
rs940689309 5430 dbSNP
rs938291558 5432 dbSNP
rs229070 5435 dbSNP
rs1270198731 5448 dbSNP
rs984801989 5464 dbSNP
rs981783076 5465 dbSNP
rs1441881862 5473 dbSNP
rs149543252 5481 dbSNP
rs186187727 5482 dbSNP
rs879458362 5490 dbSNP
rs984249487 5497 dbSNP
rs952596481 5498 dbSNP
rs1028600511 5501 dbSNP
rs975263007 5513 dbSNP
rs1267286213 5514 dbSNP
rs766888474 5515 dbSNP
rs1367351176 5518 dbSNP
rs560679241 5518 dbSNP
rs543878226 5519 dbSNP
rs1316235613 5525 dbSNP
rs760892721 5527 dbSNP
rs1267929219 5528 dbSNP
rs773671974 5532 dbSNP
rs181518113 5542 dbSNP
rs1360712136 5549 dbSNP
rs576131944 5558 dbSNP
rs966382073 5564 dbSNP
rs557495568 5569 dbSNP
rs1302241205 5573 dbSNP
rs1438243263 5578 dbSNP
rs574913035 5590 dbSNP
rs1220740122 5591 dbSNP
rs1291439903 5598 dbSNP
rs1008908781 5607 dbSNP
rs1218262946 5610 dbSNP
rs966671110 5618 dbSNP
rs1021067209 5625 dbSNP
rs1020191135 5640 dbSNP
rs1184277938 5643 dbSNP
rs564501664 5647 dbSNP
rs753465879 5650 dbSNP
rs1452384157 5653 dbSNP
rs1162716962 5656 dbSNP
rs1345144398 5675 dbSNP
rs1402199548 5687 dbSNP
rs229069 5689 dbSNP
rs573497562 5690 dbSNP
rs867026981 5693 dbSNP
rs762059446 5708 dbSNP
rs1338059926 5722 dbSNP
rs553613184 5723 dbSNP
rs1385652847 5728 dbSNP
rs1032768269 5730 dbSNP
rs1001254714 5731 dbSNP
rs1351916683 5734 dbSNP
rs377242838 5740 dbSNP
rs772117300 5745 dbSNP
rs574147200 5750 dbSNP
rs1204398420 5752 dbSNP
rs1193299747 5753 dbSNP
rs768673908 5756 dbSNP
rs1244988211 5759 dbSNP
rs1459948858 5760 dbSNP
rs749363095 5763 dbSNP
rs1233364269 5768 dbSNP
rs1471071988 5775 dbSNP
rs1046598031 5778 dbSNP
rs1406810251 5779 dbSNP
rs182551620 5780 dbSNP
rs1178008121 5787 dbSNP
rs1403321702 5789 dbSNP
rs908196215 5795 dbSNP
rs867865352 5800 dbSNP
rs1336725008 5802 dbSNP
rs896765950 5803 dbSNP
rs1336870101 5807 dbSNP
rs1444816049 5814 dbSNP
rs1278084362 5816 dbSNP
rs372971663 5822 dbSNP
rs1224310719 5824 dbSNP
rs1265197688 5827 dbSNP
rs1354233577 5828 dbSNP
rs1279316196 5852 dbSNP
rs940699218 5858 dbSNP
rs887747543 5859 dbSNP
rs921017666 5879 dbSNP
rs1049149332 5881 dbSNP
rs1179424290 5888 dbSNP
rs1232054977 5889 dbSNP
rs769675420 5892 dbSNP
rs965171606 5899 dbSNP
rs1426758214 5912 dbSNP
rs1468900286 5914 dbSNP
rs1167920481 5925 dbSNP
rs922023240 5926 dbSNP
rs1412082318 5935 dbSNP
rs1327303729 5941 dbSNP
rs1381177057 5943 dbSNP
rs1359173405 5980 dbSNP
rs976352312 5981 dbSNP
rs1405906851 5982 dbSNP
rs977311578 5983 dbSNP
rs76038321 5989 dbSNP
rs551845302 5990 dbSNP
rs1341426509 5991 dbSNP
rs913141352 5994 dbSNP
rs1010899173 6002 dbSNP
rs1272178490 6003 dbSNP
rs1361624036 6005 dbSNP
rs780912127 6023 dbSNP
rs1224442543 6037 dbSNP
rs1464819809 6051 dbSNP
rs1033731007 6055 dbSNP
rs190400635 6061 dbSNP
rs1176984712 6065 dbSNP
rs77292869 6083 dbSNP
rs546850910 6085 dbSNP
rs1046649242 6086 dbSNP
rs756911552 6091 dbSNP
rs529870250 6093 dbSNP
rs1488559264 6096 dbSNP
rs1256671936 6104 dbSNP
rs1004446531 6112 dbSNP
rs1208497187 6122 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acaauuacgauuauaCAUCCUc 5'
                         |||||| 
Target 5' ---------------GUAGGAa 3'
 		1 - 7
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000284987.5 | 3UTR | AAAACUGUGAUUUGUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000284987.5 | 3UTR | UGUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000284987.5 | 3UTR | UGUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000284987.5 | 3UTR | UGUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000284987.5 | 3UTR | GUAGGAAAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19783 ER- ER- breast cancer -0.36 5.6e-4 -0.409 9.1e-5 79 Click to see details
GSE19536 Breast cancer -0.299 1.3e-3 -0.345 2.2e-4 100 Click to see details
GSE28544 Breast cancer -0.375 3.5e-2 -0.411 2.3e-2 24 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.712 5.6e-2 -0.771 3.6e-2 6 Click to see details
GSE28260 Renal cortex and medulla 0.411 8.1e-2 0.324 1.4e-1 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.24 1.2e-1 -0.342 4.7e-2 25 Click to see details
GSE32688 Pancreatic cancer -0.18 1.6e-1 -0.116 2.6e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.192 2.1e-1 0.203 2.0e-1 20 Click to see details
GSE21687 Ependynoma primary tumors -0.093 2.3e-1 -0.046 3.6e-1 64 Click to see details
GSE17498 Multiple myeloma 0.094 2.8e-1 0.147 1.8e-1 40 Click to see details
GSE19350 CNS germ cell tumors 0.146 3.3e-1 0.274 1.9e-1 12 Click to see details
GSE42095 Differentiated embryonic stem cells 0.081 3.6e-1 0.053 4.1e-1 23 Click to see details
GSE19783 ER+ ER+ breast cancer -0.083 3.6e-1 0.017 4.7e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.071 3.7e-1 -0.014 4.7e-1 24 Click to see details
GSE38226 Liver fibrosis -0.074 3.7e-1 -0.265 1.2e-1 21 Click to see details
GSE38226 Liver fibrosis -0.074 3.7e-1 -0.265 1.2e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.527 0.02 -0.576 0.01 16 Click to see details
ESCA -0.87 0.07 -0.800 0.1 4 Click to see details
THCA -0.164 0.23 -0.154 0.24 23 Click to see details
PAAD 0.51 0.25 0.200 0.4 4 Click to see details
KIRC -0.192 0.3 -0.006 0.49 10 Click to see details
CHOL 0.588 0.3 0.500 0.33 3 Click to see details
UCEC -0.314 0.3 -0.100 0.44 5 Click to see details
LIHC -0.144 0.32 -0.055 0.43 13 Click to see details
STAD -0.145 0.33 -0.056 0.43 12 Click to see details
PRAD -0.242 0.35 -0.400 0.25 5 Click to see details
BRCA 0.08 0.39 0.207 0.23 15 Click to see details
LUSC 0.057 0.41 0.083 0.36 20 Click to see details
KIRP 0.075 0.45 -0.100 0.44 5 Click to see details
KIRP 0.075 0.45 -0.100 0.44 5 Click to see details
KIRP 0.075 0.45 -0.100 0.44 5 Click to see details
KIRP 0.075 0.45 -0.100 0.44 5 Click to see details
73 hsa-miR-155-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005808 IRAK3 interleukin 1 receptor associated kinase 3 4 1
MIRT082844 ZNF460 zinc finger protein 460 2 4
MIRT256047 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT437787 PTEN phosphatase and tensin homolog 2 1
MIRT456168 ZDHHC6 zinc finger DHHC-type containing 6 2 2
MIRT464916 TXNIP thioredoxin interacting protein 2 4
MIRT475559 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 2
MIRT499608 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 8
MIRT504220 MYO6 myosin VI 2 4
MIRT504256 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT507642 CREBRF CREB3 regulatory factor 2 2
MIRT522858 KIAA1551 KIAA1551 2 2
MIRT527505 MYD88 myeloid differentiation primary response 88 5 2
MIRT530713 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT532851 ZNF699 zinc finger protein 699 2 2
MIRT535952 MIA3 MIA family member 3, ER export factor 2 2
MIRT539041 ATXN1L ataxin 1 like 2 4
MIRT556391 LUC7L LUC7 like 2 2
MIRT558617 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT559869 ATXN3 ataxin 3 2 2
MIRT569208 SHC3 SHC adaptor protein 3 2 2
MIRT573122 C18orf25 chromosome 18 open reading frame 25 2 2
MIRT575076 Ddit4 DNA-damage-inducible transcript 4 2 2
MIRT607597 ABCF3 ATP binding cassette subfamily F member 3 2 6
MIRT609386 PHEX phosphate regulating endopeptidase homolog X-linked 2 2
MIRT610550 MDN1 midasin AAA ATPase 1 2 2
MIRT612390 TCF7L2 transcription factor 7 like 2 2 2
MIRT612910 GTDC1 glycosyltransferase like domain containing 1 2 6
MIRT613314 ARL5C ADP ribosylation factor like GTPase 5C 2 2
MIRT613356 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 4
MIRT613541 CLMP CXADR like membrane protein 2 2
MIRT617029 SYT6 synaptotagmin 6 2 2
MIRT618044 MRVI1 murine retrovirus integration site 1 homolog 2 2
MIRT619307 KIRREL kirre like nephrin family adhesion molecule 1 2 2
MIRT623209 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT625448 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT634551 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT640740 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT640906 RAB13 RAB13, member RAS oncogene family 2 2
MIRT644025 ZNF792 zinc finger protein 792 2 2
MIRT651489 WT1 Wilms tumor 1 2 2
MIRT652037 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT669093 CDK6 cyclin dependent kinase 6 2 2
MIRT696720 WNT3 Wnt family member 3 2 2
MIRT698085 TPM1 tropomyosin 1 2 2
MIRT703284 GID4 GID complex subunit 4 homolog 2 2
MIRT707183 ARHGEF33 Rho guanine nucleotide exchange factor 33 2 2
MIRT710362 CREB5 cAMP responsive element binding protein 5 2 2
MIRT713501 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT717153 LRRC3C leucine rich repeat containing 3C 2 2
MIRT719038 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 2 2
MIRT719489 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT720284 DPYSL3 dihydropyrimidinase like 3 2 2
MIRT732474 NLRP3 NLR family pyrin domain containing 3 2 0
MIRT732620 MS multiple sclerosis 1 0
MIRT732968 TGFBR2 transforming growth factor beta receptor 2 3 0
MIRT733063 AGTR1 angiotensin II receptor type 1 3 0
MIRT733206 ADAM10 ADAM metallopeptidase domain 10 1 0
MIRT733302 CRP C-reactive protein 2 0
MIRT734202 PDCD4 programmed cell death 4 3 0
MIRT734467 SIRT1 sirtuin 1 2 0
MIRT734701 Foxo3 forkhead box O3 1 0
MIRT734889 SP4 Sp4 transcription factor 2 0
MIRT735047 BATF basic leucine zipper ATF-like transcription factor 1 0
MIRT735048 SPI1 Spi-1 proto-oncogene 1 0
MIRT735734 PICALM phosphatidylinositol binding clathrin assembly protein 3 0
MIRT735944 TNF tumor necrosis factor 1 0
MIRT736131 MYLK myosin light chain kinase 2 0
MIRT736780 FOXP3 forkhead box P3 1 0
MIRT736781 CEBPB CCAAT/enhancer binding protein beta 1 0
MIRT736858 WEE1 WEE1 G2 checkpoint kinase 2 0
MIRT736873 TLR3 toll like receptor 3 2 0
MIRT736902 CFH complement factor H 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-155 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-155 Cyclophosphamide approved 2907 Quantitative real-time PCR p53+/+ pregnant mice 20170545 2010 down-regulated
miR-155 Estrogen NULL NULL Microarray mouse uterus 20720260 2010 up-regulated
miR-155 Estrogen NULL NULL Quantitative real-time PCR mouse uterus 20720260 2010 up-regulated
miR-155 Camptothecin NULL 24360 Microarray human cancer cells 24252850 2014 down-regulated
miR-155 Cocaine NULL 446220 Quantitative real-time PCR monocyte derived dendritic cells 24391808 2014 down-regulated
miR-155 Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-155 Triptolide NULL 107985 Quantitative real-time PCR peripheral blood mononuclear cells (PBMCs) of RA (rheumatoid arthritis) 24909288 2014 down-regulated
miR-155 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-155 Lithium (Li) approved 3028194 Quantitative real-time PCR lymphoblastoid cell lines (LCLs) 19254429 2009 up-regulated
miR-155 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 down-regulated
miR-155 Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines HTR-8 20417706 2010 up-regulated
miR-155 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 down-regulated
miR-155 Aidi injection NULL NULL Microarray human breast cancer cells 21563499 2011 down-regulated
miR-155 Gemcitabine approved 60750 Quantitative real-time PCR pancreatic cancer 21738581 2011 down-regulated
miR-155 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-155 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-155 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miR-155 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 up-regulated
miR-155 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 up-regulated
miR-155 Glucocorticoid NULL NULL Microarray RAW264.7 cells 22326887 2012 down-regulated
miR-155 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-155 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-155 Glucocorticoid NULL NULL TaqMan low-density array Eosinophilic esophagitis 22815788 2012 up-regulated
miR-155 Adrenaline approved 5816 Quantitative real-time PCR colon cancer HT29 cells 23036199 2012 up-regulated
miR-155 Leptin NULL NULL Quantitative real-time PCR muscles 20800581 2010 down-regulated
miR-155 Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 up-regulated
miR-155 Sinomenine NULL 5459308 Quantitative real-time PCR Colitis 24066068 2013 down-regualted
miR-155 Praziquantel approved 4891 Quantitative real-time PCR liver cell lines 25051829 2014 down-regualted
miR-155 Uric acid NULL 1175 Quantitative real-time PCR endothelial cells 23996753 2013 up-regualted
miR-155 Hydroxychloroquine approved 3652 Microarray mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-155 Tripterygium wilfordii Hook F resistant tissue
hsa-mir-155 Doxorubicin 31703 NSC123127 approved resistant cell line (W1)
hsa-mir-155 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-155 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-155-3p Cisplatin 5460033 NSC119875 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-miR-155-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-155-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-155-3p Paclitaxel 36314 NSC125973 approved sensitive Low Breast Cancer cell line (MCF-7, SKBR3, MDA-MB-231)
hsa-miR-155-3p Temozolomide 5394 NSC362856 approved resistant Low Glioblastoma cell line (A172, U87)
hsa-miR-155-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-155-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-155-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-155-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-155-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-155-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-155-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-155-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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