pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TTC38   
Synonyms LL22NC03-5H6.5
Description tetratricopeptide repeat domain 38
Transcript NM_017931   
Expression
Putative miRNA Targets on TTC38
3'UTR of TTC38
(miRNA target sites are highlighted)
>TTC38|NM_017931|3'UTR
   1 GCCAGCCTGGCCGCCTCCACCCTGCAGAACCTCAGTGGTGGCGTCACTGCGTCCAGTCAGCTGCTCCACCGGGTTAGGGT
  81 CAGGAGACGGCCAGAGCCTGTTTGTTAGGGCTGTTAGAGGGTGATCTTCAGTTTTACAGGAAGTGGGTCACGGGTTAATT
 161 TTAAATGTGATTCCGAATCTCCTTTCAGTCCTCGAGAAGGGCCAATGAGCATTTTTCAGCAGTCACAGCCAGTGTGAGTG
 241 CTGCTCTTTCCACCTGCCTTGCAAATTCTGTTTCCCAGGGGAATGTGTCTACTGCCTGGTGGTTCAAAGGTTGGAAGGCA
 321 GGGCAGAGGTGGGGGCTGATTCTGCTGGGACAGGTCTTCCAGAGGCAGCCTCCCCCCACTGCCTGTCCCCGTCCCCACCA
 401 GGCTGCCCTTGGGATGGACCTTTTCATTCTTTTCTTTATATTCTAGACAGTCTCTGTTGTCTCATTGTGTTGCTGTCCCA
 481 TTTTTCAGGTGAGGGTACCGGGGTAGGGGAGTGGCCTGCCCAGGGTCACACTATGAGAGGCCCCCACCTGCTGCCTTTGG
 561 ACGCAGCCCCCTGCTGCTGCATCCACCACCCTTCTTACAGATCAGCGCGCACATGGGGTCCTTCTGCTGTCTCTGGGGCG
 641 AGTCTTGGAGCCCCCTGGGGGGCTCTGTTGGTGCTGATTTGGACCCGTTTCTCTTTTTAAACTGCACATCATAACAGGGC
 721 TTCATGTCGAGCATGATTTTAATCATAAATGCACTTCTGAGGTGCAAGGATTGAGCTCAGAGCTGCTCTGTTGTGGCAAA
 801 ACCCAAAGTGCTGTGATGTGTGGCTGTGACAAGCCTGGAGCGGGTCCTGTGAGCGCCGCCTCTGTCTCCTGCTTCCCCAC
 881 TGAACGCCTGCTGAATGTGCCGCTGACTCAGCTGTGCTGCTTTCAGCCCTCCTGTGAGGGGCGGTCCCAGTGCACAGATG
 961 TTTTTCAAGTTCCTCAGTTTGTACTGAAATTAGGGATTCATCAGGGCAGGAAGCAGGCAGGCCTCTCAGAAGGGAGAGGA
1041 GGCCTCCAAATCTATTGAGTCCCCACAGTTTGCTCAAGCCCAGGCAAATTTCTGTGATTAAAATGAATTCATCAGTTCCT
1121 CCAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguucccuuaccGUCCCUUUa 5'
                       |||||:|| 
Target 5' aaattctgtttccCAGGGGAAt 3'
263 - 284 129.00 -14.67
2
miRNA  3' cgGUUCCCUU---ACCGUCCCUUUa 5'
            ::|||| |    ||:||||:|: 
Target 5' ggTGAGGGTACCGGGGTAGGGGAGt 3'
488 - 512 128.00 -22.20
3
miRNA  3' cgguucccuuacCGUCCCUUUa 5'
                      | |||||:| 
Target 5' gcaggcctctcaGAAGGGAGAg 3'
1017 - 1038 126.00 -11.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30494112 7 COSMIC
COSN31497119 18 COSMIC
COSN31481911 34 COSMIC
COSN30111611 43 COSMIC
COSN13921217 44 COSMIC
COSN5865671 128 COSMIC
COSN26585690 146 COSMIC
COSN25091607 259 COSMIC
COSN24904650 387 COSMIC
COSN5993847 887 COSMIC
COSN8020299 944 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776821650 5 dbSNP
rs1252568541 6 dbSNP
rs761928247 10 dbSNP
rs370159601 13 dbSNP
rs750681441 14 dbSNP
rs759350048 21 dbSNP
rs767439732 22 dbSNP
rs752640013 24 dbSNP
rs57993528 28 dbSNP
rs777121703 39 dbSNP
rs988374891 40 dbSNP
rs1376082846 42 dbSNP
rs577801335 43 dbSNP
rs374930102 44 dbSNP
rs1372225956 47 dbSNP
rs778468694 51 dbSNP
rs745532056 52 dbSNP
rs979557722 61 dbSNP
rs1040669617 65 dbSNP
rs543650298 69 dbSNP
rs185955357 70 dbSNP
rs573950872 71 dbSNP
rs991204562 72 dbSNP
rs1260146874 77 dbSNP
rs543316344 82 dbSNP
rs1165080413 85 dbSNP
rs949768716 90 dbSNP
rs1046950312 100 dbSNP
rs1424397531 101 dbSNP
rs111839774 105 dbSNP
rs994033052 107 dbSNP
rs1357134281 111 dbSNP
rs1332061815 114 dbSNP
rs1034934340 119 dbSNP
rs528113421 122 dbSNP
rs11556944 125 dbSNP
rs1289522347 127 dbSNP
rs941314003 132 dbSNP
rs1038200357 138 dbSNP
rs1386657092 139 dbSNP
rs551171044 143 dbSNP
rs1374775280 144 dbSNP
rs1475717048 145 dbSNP
rs899706324 148 dbSNP
rs148046728 152 dbSNP
rs763246864 153 dbSNP
rs1263126798 155 dbSNP
rs141739653 163 dbSNP
rs117945146 168 dbSNP
rs191676607 175 dbSNP
rs1463167652 176 dbSNP
rs1220519349 182 dbSNP
rs1009966158 191 dbSNP
rs1020984623 194 dbSNP
rs979222380 195 dbSNP
rs371392806 206 dbSNP
rs1481540881 218 dbSNP
rs923581909 227 dbSNP
rs968697310 229 dbSNP
rs376085308 237 dbSNP
rs1326943137 243 dbSNP
rs1297658265 246 dbSNP
rs1437286081 247 dbSNP
rs1386587030 252 dbSNP
rs1320083968 258 dbSNP
rs979694090 275 dbSNP
rs1161820466 285 dbSNP
rs41279833 285 dbSNP
rs959542375 292 dbSNP
rs1237563262 300 dbSNP
rs991172002 302 dbSNP
rs917003202 310 dbSNP
rs949851861 311 dbSNP
rs1447084179 328 dbSNP
rs1184950008 329 dbSNP
rs753136969 332 dbSNP
rs1385434762 334 dbSNP
rs982839481 344 dbSNP
rs1452974568 355 dbSNP
rs751991398 361 dbSNP
rs908233950 364 dbSNP
rs1339837762 365 dbSNP
rs1252962492 366 dbSNP
rs145958827 371 dbSNP
rs565907006 374 dbSNP
rs1356656326 375 dbSNP
rs942092766 376 dbSNP
rs535052289 378 dbSNP
rs1397693393 381 dbSNP
rs1170974162 391 dbSNP
rs1298103396 392 dbSNP
rs1398813937 403 dbSNP
rs897823995 413 dbSNP
rs921064290 414 dbSNP
rs1478733982 421 dbSNP
rs1244557446 427 dbSNP
rs932484952 432 dbSNP
rs1438139051 437 dbSNP
rs1253678387 441 dbSNP
rs1202809312 445 dbSNP
rs1341364109 447 dbSNP
rs1281022011 448 dbSNP
rs57866552 449 dbSNP
rs753360584 451 dbSNP
rs896372003 455 dbSNP
rs577763998 460 dbSNP
rs778849834 466 dbSNP
rs1408449836 468 dbSNP
rs1370428009 470 dbSNP
rs748098262 500 dbSNP
rs182088366 501 dbSNP
rs1171538740 504 dbSNP
rs979576245 512 dbSNP
rs1413804229 517 dbSNP
rs903857859 525 dbSNP
rs1227959893 529 dbSNP
rs1482613020 533 dbSNP
rs1257317048 534 dbSNP
rs1258057363 534 dbSNP
rs956448510 536 dbSNP
rs975715572 542 dbSNP
rs1276560065 546 dbSNP
rs187134197 548 dbSNP
rs1330074223 549 dbSNP
rs1290460516 551 dbSNP
rs1226876868 554 dbSNP
rs1204971074 562 dbSNP
rs953588481 563 dbSNP
rs1033907188 564 dbSNP
rs58980421 567 dbSNP
rs913671136 568 dbSNP
rs1390313344 569 dbSNP
rs746849141 571 dbSNP
rs909358733 576 dbSNP
rs1418329644 577 dbSNP
rs1179765293 578 dbSNP
rs771151654 583 dbSNP
rs1209440901 585 dbSNP
rs1465408190 589 dbSNP
rs1270209118 595 dbSNP
rs1207086285 599 dbSNP
rs1328807092 600 dbSNP
rs564682278 601 dbSNP
rs982590159 607 dbSNP
rs542926584 608 dbSNP
rs1377604248 609 dbSNP
rs528806788 610 dbSNP
rs1366776728 612 dbSNP
rs962378242 614 dbSNP
rs12165966 625 dbSNP
rs1318060416 634 dbSNP
rs1177168255 640 dbSNP
rs776748938 641 dbSNP
rs1445995792 651 dbSNP
rs560025443 656 dbSNP
rs1394810940 657 dbSNP
rs1403410299 657 dbSNP
rs919303410 657 dbSNP
rs1290840445 659 dbSNP
rs374803589 661 dbSNP
rs1450114828 662 dbSNP
rs1057031308 666 dbSNP
rs1382539374 670 dbSNP
rs1186799353 686 dbSNP
rs921200149 687 dbSNP
rs1224162710 688 dbSNP
rs9615938 688 dbSNP
rs1320297822 696 dbSNP
rs1051364694 702 dbSNP
rs1289739766 703 dbSNP
rs1229811912 707 dbSNP
rs912436996 712 dbSNP
rs1263147828 714 dbSNP
rs945414630 719 dbSNP
rs1042487074 721 dbSNP
rs903837029 723 dbSNP
rs114403288 729 dbSNP
rs1030849485 730 dbSNP
rs564967637 732 dbSNP
rs530572657 735 dbSNP
rs12166072 758 dbSNP
rs956416217 768 dbSNP
rs1055070320 772 dbSNP
rs1193348819 775 dbSNP
rs1166782931 780 dbSNP
rs1029984475 782 dbSNP
rs550703121 783 dbSNP
rs895387967 789 dbSNP
rs559057380 791 dbSNP
rs1193174964 802 dbSNP
rs1013823076 806 dbSNP
rs1487681568 820 dbSNP
rs953054351 834 dbSNP
rs1206359840 839 dbSNP
rs561029808 842 dbSNP
rs1226944880 843 dbSNP
rs1025559017 844 dbSNP
rs950915898 854 dbSNP
rs1302898340 855 dbSNP
rs192471290 856 dbSNP
rs1308407739 859 dbSNP
rs1412811372 860 dbSNP
rs972224789 863 dbSNP
rs1015354916 865 dbSNP
rs919438486 878 dbSNP
rs941150424 880 dbSNP
rs769778747 886 dbSNP
rs775909128 887 dbSNP
rs1431621157 890 dbSNP
rs1057166622 892 dbSNP
rs1338155053 900 dbSNP
rs1183331025 902 dbSNP
rs920966298 903 dbSNP
rs1250201648 907 dbSNP
rs915897686 909 dbSNP
rs1483895404 915 dbSNP
rs1257212624 918 dbSNP
rs1207495889 920 dbSNP
rs1311237968 924 dbSNP
rs1406616856 926 dbSNP
rs1288605664 929 dbSNP
rs1229930789 930 dbSNP
rs1348432571 943 dbSNP
rs948781481 955 dbSNP
rs953940794 958 dbSNP
rs986738812 969 dbSNP
rs1045383436 995 dbSNP
rs912353018 1002 dbSNP
rs945244033 1003 dbSNP
rs1304651347 1004 dbSNP
rs978561063 1008 dbSNP
rs1001205811 1011 dbSNP
rs925354741 1015 dbSNP
rs1473750599 1020 dbSNP
rs936784421 1023 dbSNP
rs1410189998 1024 dbSNP
rs1181596454 1032 dbSNP
rs1052246562 1034 dbSNP
rs1216940064 1039 dbSNP
rs1179551362 1040 dbSNP
rs1258953051 1040 dbSNP
rs1285786823 1040 dbSNP
rs1317090556 1042 dbSNP
rs1215447696 1044 dbSNP
rs1482646930 1053 dbSNP
rs1268323749 1055 dbSNP
rs1210234272 1058 dbSNP
rs1326697530 1059 dbSNP
rs546556752 1061 dbSNP
rs892329756 1064 dbSNP
rs997253854 1067 dbSNP
rs1055038549 1076 dbSNP
rs895188970 1084 dbSNP
rs949627151 1085 dbSNP
rs1316016794 1091 dbSNP
rs5768362 1093 dbSNP
rs1200661397 1096 dbSNP
rs1046650198 1097 dbSNP
rs1007187323 1109 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084074. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000381031.3 | 3UTR | CAAGGGAAAAAAAAAAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000381031.3 | 3UTR | UCAAGGGAAAAAAAAAAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000381031.3 | 3UTR | UCAAGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000381031.3 | 3UTR | UCAAGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000381031.3 | 3UTR | UCAAGGGAAAAAAAAAAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000381031.3 | 3UTR | AAGGGAAAAAAAAAAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084074
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SantaCruzAb
Location of target site ENST00000381031.3 | 3UTR | UCAAGGGAAAAAAAAAAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000381031.3 | 3UTR | AAGGGAAAAAAAAAAAAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000381031.3 | 3UTR | UCAAGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000381031.3 | 3UTR | AAGGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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