pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZDHHC22   
Synonyms C14orf59
Description zinc finger DHHC-type containing 22
Transcript NM_174976   
Expression
Putative miRNA Targets on ZDHHC22
3'UTR of ZDHHC22
(miRNA target sites are highlighted)
>ZDHHC22|NM_174976|3'UTR
   1 TAGACACTCCCGTCATTTATCTCTCTGTCTCTGTCTTGACTCCTCCTGAGCATAAAACCATGGCAGCCTTGTCTCCACCC
  81 ATGACTCACTACAACCTTGTGCTGGTAAGGTCCTAGCATCTTCCCCTCACCTTCCACCCATGAGAACAGCGTGAGCTGGT
 161 GGATCATGACAAGGAGGAAAAATGTCCCCCCAGGCATTTCTAGGCTCCTCACGAGCCAGCCAGGTGGCTGCTAGCTGTTA
 241 GGCTGCCTCTGCTTTCTTTCCGTCCCCTTGGGATCCCTGCTTTCCCCCTCTTCCTGGCTCATCCATTCTCCACCGTGTCT
 321 CATTCATCACTGCTGTCTGCTAGAGCCCTTCCTCTCAGCCCCCATGTTGGGAGAGGGGAGTGGATTCTTGCTGCTGGTAT
 401 GAGACTCCCTGGGACCTAGAGGCTGGCAAATGTTTAAAATCACCACGTGTAAGAGGCAGCCAAGTCAGCTCTGCCAACTG
 481 CTAGGGGAGTTGGGAAAGAGTGGGTGTGTGTCCGCATCCCCTCTGTAGGAAAAAGAACTTAGTAGCTTGCTGCTCCCTCA
 561 CCACCCCCCACCAGGTTCAAGACCCTTTTTCTGGGAGACAGCAATCAATGGCCTGCTTTTTCCAAATGTTATTCCCTGTC
 641 CACCCTGCCCCATCTGGCCGGCCCAGCCCAGTCCAGGACCTGGCTGGATGCTTCCTGTCCCTGGAACTCTTCCAGCCTTT
 721 CTACTTGATCTCCAGCCCCCAGGTCTTTGCCAGATGATGGGAAGGCAAGGAAGAAGGGACAGGGAAAGATAATTACTGAT
 801 AAATGAAGGGGATATTCGACTGTATAACCATATGGAAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGAGAGAGAGAGAG
 881 AGAGATGGGTGGTGGTGAGAAGTGTTGTTAGAAACATATAGGAATAATGCCTAGGGGAAAGGGAGAAGTGAGAGGGACAA
 961 TTGGGTTCATTTATGCCCTATACAAAGGGCATTCCAGCAGCTGAAACTCTTCAATGTTTGAATGGCTGCCTGTGAAGGTA
1041 GTGAGTGCCCCATCACTGGAGGTATTCCAGCAGAGTCTAGGCAGTCGTCTGCCAGGCATGCTGTGGAAGGGATTTCTGTA
1121 CAGGGTCATTCTAGGTGAGCTTACACATTCCTTCCAACCCCAAGGTTCTGATGTCCTGGTTGTGATTGCTGGACCCAGAG
1201 GCAAGATCTGCAGAGATGCCTGTGAGATATTTGCTTTCCTAGAGGGGAGTGTGGGCATGGGAGGGGTCTGAAAATCAGGA
1281 CCCAACCCAGCCACTGAAGAGAGAGTCTCTGCAGAGACAGGGCTACCTGGGTGGTTGAGGGGACTGACATTTGAGGACAG
1361 GGAGATGGAGCAGTGTCATTGTCAGTGGCAGGGCATGGGGGGCAGTGGTGAGCTAAGGCTGAGGAGTGGAGATGACCAGA
1441 ATATAAGGGTGCAATTCCCAGACCATCCCTGCGCATCTGACTGACTCCGGTGGAGGCACTGCTGTGTGTTTTCTGAAACC
1521 TAGAGGACCAGACCTCTGGGGCATATAAGGGAGTAGGGACAACACAAGTGCCCCCTCCTGACTGGGTCCCAAAGCCAATA
1601 TGACATCCATGCAGGCAGCAGTGCTGAATCCATGCCCTGCAATGTCCAACCGCCAACTGCAGTGACCCGCTGATAGCTGC
1681 GCAACAGCCTGGGTTCTTGAGCAGAGATTGGGAGGACTTTACTGTGGTTCTGCCTTCACACCCCCTAGAGAGCTAATGTA
1761 GTATTGGCTCCACCTGCTCACATTTCTCCCTCCCATACTCATTCCTTCACTCATCCATCCTACGTATATTTATTGAGTGC
1841 CAACTACGTTCCCAGCCTCTTCCAGGCACTGGCAATGCAGTGATGAACAGGATGACAAGATTCATGCCATCAGGGGCACC
1921 TTGTCACTGCCGTCTGTGCACTGATTCACACTCCCTGCAAAATGGTCACTCTGCCATCTTGGTGGTTGGTGGGGCAGGTC
2001 ATTTGGAAATAAAGAATGTGATAGAGATGGCTGAAGAGGGGAAGCCTAGGCTGCCTCAATGGAGGAGTCGCTGGGGGCAT
2081 TTTCACCCACAATTCTGGCCATACTTAAGCAATGGGAGGGAGAGGGAGGAGGGGAAGATCTGGGCAATTTTGGCCTTGAC
2161 TCTTTCCTGGCTCCAGAGCTCAAGCTTAGAAGCCAGCCCTGCTATTTCCAGCCTCCTGAAGGCTCAGCACGGTGAGGCCT
2241 GACATCCTGGGGAAGGGCAACAGGGAGACCTACAGGATGTTGGCTGCTTGCAGACTGGTCAATGGGGGATGACGGTGGGG
2321 AGGTTGCCAGATGTGAGACTTGAGTAGCATTTGTACACATGGCCCTGTATTGTCCTTGAAGAACATCAATAAAATATATG
2401 GTTTTAAATTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cacacGAGA--GACC-AGUUGGUAg 5'
               ||||  |||| ||| |||| 
Target 5' tccccCTCTTCCTGGCTCATCCATt 3'
283 - 307 135.00 -15.90
2
miRNA  3' cacACGAG-AGACCAGUUGGUAg 5'
             | :||  |||  :|||||| 
Target 5' ggaTATTCGACTGTATAACCATa 3'
810 - 832 135.00 -9.70
3
miRNA  3' cacacgagagaccagUUGGUAg 5'
                         |||||| 
Target 5' tcctcctgagcataaAACCATg 3'
41 - 62 120.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26134186 9 COSMIC
COSN30455030 11 COSMIC
COSN30505580 11 COSMIC
COSN31569526 23 COSMIC
COSN31612068 29 COSMIC
COSN30188207 51 COSMIC
COSN31559287 112 COSMIC
COSN30742955 136 COSMIC
COSN6543003 194 COSMIC
COSN30534515 201 COSMIC
COSN28085504 237 COSMIC
COSN20111508 865 COSMIC
COSN16278086 869 COSMIC
COSN19044874 1101 COSMIC
COSN7026966 1248 COSMIC
COSN5750911 1745 COSMIC
COSN8850424 2069 COSMIC
COSN8850423 2097 COSMIC
COSN21837174 2216 COSMIC
COSN24186971 2314 COSMIC
COSN22580690 2326 COSMIC
COSN19462383 2362 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1272915567 5 dbSNP
rs756765997 6 dbSNP
rs746638897 11 dbSNP
rs369098841 12 dbSNP
rs907795526 24 dbSNP
rs983372914 26 dbSNP
rs1374302723 27 dbSNP
rs769555156 33 dbSNP
rs1440110838 45 dbSNP
rs187121162 49 dbSNP
rs1037186464 52 dbSNP
rs1314504174 59 dbSNP
rs940432826 63 dbSNP
rs907664416 74 dbSNP
rs1336471926 76 dbSNP
rs1272616603 78 dbSNP
rs1048711134 81 dbSNP
rs1278065074 88 dbSNP
rs1371586316 89 dbSNP
rs1350250868 95 dbSNP
rs772416161 102 dbSNP
rs142698447 105 dbSNP
rs1000338886 108 dbSNP
rs530292714 115 dbSNP
rs1251865401 120 dbSNP
rs1331125254 125 dbSNP
rs1410781779 134 dbSNP
rs561294049 140 dbSNP
rs1362800113 142 dbSNP
rs1478153289 147 dbSNP
rs911700247 150 dbSNP
rs556867757 151 dbSNP
rs1308632093 153 dbSNP
rs1397283924 162 dbSNP
rs956104894 170 dbSNP
rs1393157508 172 dbSNP
rs1033095287 181 dbSNP
rs1178630528 186 dbSNP
rs1468922507 190 dbSNP
rs1235004978 192 dbSNP
rs1335358440 193 dbSNP
rs1235331347 196 dbSNP
rs1306051309 200 dbSNP
rs1346213633 205 dbSNP
rs544711526 207 dbSNP
rs1010470411 213 dbSNP
rs1252463440 216 dbSNP
rs1481914395 217 dbSNP
rs760835219 218 dbSNP
rs575610899 223 dbSNP
rs368097326 226 dbSNP
rs1249245608 230 dbSNP
rs75688671 261 dbSNP
rs779110226 262 dbSNP
rs1393032707 264 dbSNP
rs1276100162 268 dbSNP
rs1453636295 277 dbSNP
rs1212319444 286 dbSNP
rs757820682 291 dbSNP
rs1347988893 300 dbSNP
rs866718618 303 dbSNP
rs1323696546 305 dbSNP
rs1237952006 311 dbSNP
rs749784690 313 dbSNP
rs1279870813 315 dbSNP
rs1369216496 316 dbSNP
rs1447054158 321 dbSNP
rs1014905128 335 dbSNP
rs1440552438 338 dbSNP
rs1358730705 347 dbSNP
rs1311303664 350 dbSNP
rs931930071 353 dbSNP
rs900605812 363 dbSNP
rs896100204 365 dbSNP
rs1250237972 366 dbSNP
rs1037758363 367 dbSNP
rs576769601 375 dbSNP
rs539353349 378 dbSNP
rs1215163025 397 dbSNP
rs1004377744 404 dbSNP
rs1467759869 411 dbSNP
rs1376208089 419 dbSNP
rs1263615830 424 dbSNP
rs886150852 426 dbSNP
rs866317032 427 dbSNP
rs762371208 447 dbSNP
rs907679540 466 dbSNP
rs1169700708 468 dbSNP
rs1372572255 477 dbSNP
rs148491715 483 dbSNP
rs930303505 485 dbSNP
rs921576205 487 dbSNP
rs3742741 499 dbSNP
rs1461149235 508 dbSNP
rs949325858 513 dbSNP
rs115264386 514 dbSNP
rs1295569596 515 dbSNP
rs371389073 517 dbSNP
rs1356674964 523 dbSNP
rs944612804 526 dbSNP
rs1234522140 528 dbSNP
rs959008516 530 dbSNP
rs1032065885 535 dbSNP
rs911851050 543 dbSNP
rs988601759 545 dbSNP
rs11621913 550 dbSNP
rs955863538 552 dbSNP
rs1284737783 553 dbSNP
rs926001216 562 dbSNP
rs1190104952 564 dbSNP
rs1318610977 567 dbSNP
rs978861419 569 dbSNP
rs756443538 574 dbSNP
rs753060599 580 dbSNP
rs1023375989 583 dbSNP
rs571146654 591 dbSNP
rs1288660909 597 dbSNP
rs1376556906 604 dbSNP
rs1417190281 615 dbSNP
rs960567206 618 dbSNP
rs1354318779 623 dbSNP
rs1223986266 628 dbSNP
rs969315476 629 dbSNP
rs1291660277 633 dbSNP
rs1020443219 634 dbSNP
rs1015802469 639 dbSNP
rs574314010 641 dbSNP
rs752703 642 dbSNP
rs534373002 654 dbSNP
rs764528712 656 dbSNP
rs1027132478 659 dbSNP
rs994982156 661 dbSNP
rs373267387 662 dbSNP
rs900282430 666 dbSNP
rs567030555 668 dbSNP
rs369501265 669 dbSNP
rs944388575 670 dbSNP
rs1037810896 679 dbSNP
rs552190428 685 dbSNP
rs1358055975 688 dbSNP
rs890340896 698 dbSNP
rs1053035186 700 dbSNP
rs1262059277 719 dbSNP
rs942121520 727 dbSNP
rs1184189123 728 dbSNP
rs934460583 729 dbSNP
rs1231975638 733 dbSNP
rs1486568910 734 dbSNP
rs1438332732 735 dbSNP
rs1242617063 736 dbSNP
rs1234698950 738 dbSNP
rs1479769130 743 dbSNP
rs1220826232 752 dbSNP
rs886307608 758 dbSNP
rs765839034 760 dbSNP
rs1332366947 762 dbSNP
rs925761208 765 dbSNP
rs1047567669 766 dbSNP
rs1411041975 770 dbSNP
rs949203716 777 dbSNP
rs1352310366 781 dbSNP
rs145458421 783 dbSNP
rs1372742618 790 dbSNP
rs1438357660 800 dbSNP
rs948809349 802 dbSNP
rs182835649 807 dbSNP
rs916037424 810 dbSNP
rs763159289 817 dbSNP
rs990669587 818 dbSNP
rs1216310293 820 dbSNP
rs993199311 823 dbSNP
rs547335875 825 dbSNP
rs1277815443 828 dbSNP
rs1380547308 833 dbSNP
rs1364246776 835 dbSNP
rs1289964540 836 dbSNP
rs1275174640 837 dbSNP
rs375230791 838 dbSNP
rs1305909255 850 dbSNP
rs866429110 852 dbSNP
rs960076671 853 dbSNP
rs1392711547 855 dbSNP
rs1328286364 857 dbSNP
rs370703937 859 dbSNP
rs149602941 861 dbSNP
rs140188712 863 dbSNP
rs144140985 865 dbSNP
rs367639970 866 dbSNP
rs1165016141 867 dbSNP
rs1491459943 867 dbSNP
rs376434680 867 dbSNP
rs4021329 867 dbSNP
rs888061 867 dbSNP
rs1423066568 869 dbSNP
rs867679749 869 dbSNP
rs1167454330 871 dbSNP
rs1330992427 871 dbSNP
rs1348484646 878 dbSNP
rs1457668315 883 dbSNP
rs1289821567 886 dbSNP
rs1387724723 886 dbSNP
rs142042377 886 dbSNP
rs1342652528 887 dbSNP
rs1458811667 887 dbSNP
rs1190528029 890 dbSNP
rs1467043192 891 dbSNP
rs1254844678 893 dbSNP
rs952994137 894 dbSNP
rs1027101260 895 dbSNP
rs370449827 899 dbSNP
rs1382596220 928 dbSNP
rs375019907 929 dbSNP
rs1418405183 932 dbSNP
rs1457167553 933 dbSNP
rs561543111 935 dbSNP
rs1416021450 941 dbSNP
rs1017359653 945 dbSNP
rs1300604631 950 dbSNP
rs1225607095 961 dbSNP
rs1309302838 965 dbSNP
rs1391658969 974 dbSNP
rs1296449271 980 dbSNP
rs1351315051 986 dbSNP
rs1239318964 1001 dbSNP
rs550850875 1002 dbSNP
rs531082828 1014 dbSNP
rs1349967901 1022 dbSNP
rs548730910 1025 dbSNP
rs1369374888 1029 dbSNP
rs762474758 1033 dbSNP
rs1235828640 1034 dbSNP
rs1483031104 1041 dbSNP
rs1178064506 1046 dbSNP
rs1240401666 1048 dbSNP
rs1438160042 1049 dbSNP
rs1158425772 1052 dbSNP
rs1396171735 1052 dbSNP
rs1442079219 1056 dbSNP
rs1052796448 1061 dbSNP
rs1400109058 1067 dbSNP
rs934553482 1070 dbSNP
rs1416679735 1081 dbSNP
rs966494291 1086 dbSNP
rs904475906 1087 dbSNP
rs565226804 1092 dbSNP
rs1374218191 1094 dbSNP
rs1174692377 1095 dbSNP
rs989011842 1096 dbSNP
rs955013536 1098 dbSNP
rs1217446339 1109 dbSNP
rs1030615778 1110 dbSNP
rs948584508 1116 dbSNP
rs773036084 1117 dbSNP
rs964743936 1119 dbSNP
rs1456633738 1127 dbSNP
rs1178356812 1134 dbSNP
rs1016263835 1144 dbSNP
rs992940098 1150 dbSNP
rs377399724 1157 dbSNP
rs1006602822 1160 dbSNP
rs886529318 1165 dbSNP
rs1409985977 1167 dbSNP
rs765154942 1171 dbSNP
rs1172199341 1172 dbSNP
rs545036629 1173 dbSNP
rs1464800087 1182 dbSNP
rs1248203128 1189 dbSNP
rs938791382 1190 dbSNP
rs1274917624 1193 dbSNP
rs1481713070 1195 dbSNP
rs1434193879 1201 dbSNP
rs1252140987 1212 dbSNP
rs1362575813 1229 dbSNP
rs1215195057 1233 dbSNP
rs530638153 1235 dbSNP
rs1345889604 1241 dbSNP
rs572881451 1249 dbSNP
rs1009030662 1285 dbSNP
rs879597149 1287 dbSNP
rs952961557 1307 dbSNP
rs1054991649 1326 dbSNP
rs191739417 1331 dbSNP
rs975951701 1337 dbSNP
rs74069083 1347 dbSNP
rs1305242058 1348 dbSNP
rs945013039 1350 dbSNP
rs1477288753 1362 dbSNP
rs1165268166 1365 dbSNP
rs913663615 1379 dbSNP
rs1017745899 1386 dbSNP
rs986939742 1391 dbSNP
rs1322684105 1395 dbSNP
rs1008631285 1401 dbSNP
rs1393529394 1403 dbSNP
rs574598318 1407 dbSNP
rs186908464 1417 dbSNP
rs954475284 1419 dbSNP
rs1031335609 1423 dbSNP
rs1373519173 1424 dbSNP
rs954879349 1426 dbSNP
rs1218237823 1436 dbSNP
rs998562911 1437 dbSNP
rs1284946430 1441 dbSNP
rs1358748427 1449 dbSNP
rs904402527 1472 dbSNP
rs544065371 1473 dbSNP
rs772469308 1474 dbSNP
rs1219485203 1477 dbSNP
rs117502738 1481 dbSNP
rs1487642094 1487 dbSNP
rs369054203 1488 dbSNP
rs558345229 1489 dbSNP
rs1471617375 1499 dbSNP
rs950751016 1510 dbSNP
rs1183673491 1516 dbSNP
rs538705596 1524 dbSNP
rs1408485979 1526 dbSNP
rs4903545 1535 dbSNP
rs749325495 1539 dbSNP
rs1359841041 1544 dbSNP
rs1399412481 1554 dbSNP
rs1014069014 1560 dbSNP
rs1187584066 1566 dbSNP
rs1484713553 1568 dbSNP
rs1283941454 1572 dbSNP
rs896363763 1573 dbSNP
rs1047010840 1576 dbSNP
rs1282621781 1577 dbSNP
rs1284418142 1578 dbSNP
rs1353657998 1580 dbSNP
rs778213762 1582 dbSNP
rs1211711340 1583 dbSNP
rs920141445 1585 dbSNP
rs1259489267 1597 dbSNP
rs1241554972 1604 dbSNP
rs1186478362 1622 dbSNP
rs1233234974 1631 dbSNP
rs1441259302 1641 dbSNP
rs139506830 1644 dbSNP
rs975707148 1646 dbSNP
rs1412591219 1647 dbSNP
rs964671545 1649 dbSNP
rs1173214657 1650 dbSNP
rs2041822 1651 dbSNP
rs112249103 1652 dbSNP
rs565087948 1653 dbSNP
rs78191721 1659 dbSNP
rs551198596 1668 dbSNP
rs1167168435 1669 dbSNP
rs998489344 1672 dbSNP
rs1050901685 1679 dbSNP
rs933718523 1680 dbSNP
rs920979231 1681 dbSNP
rs1199405650 1685 dbSNP
rs1258233037 1686 dbSNP
rs1458840492 1693 dbSNP
rs1196476146 1704 dbSNP
rs974912025 1708 dbSNP
rs1454636418 1715 dbSNP
rs964853476 1727 dbSNP
rs376620396 1739 dbSNP
rs1367719476 1740 dbSNP
rs1467422476 1741 dbSNP
rs115272500 1742 dbSNP
rs1021937763 1744 dbSNP
rs373595119 1745 dbSNP
rs1231841741 1747 dbSNP
rs992238123 1757 dbSNP
rs183725206 1758 dbSNP
rs765996327 1762 dbSNP
rs1033700900 1766 dbSNP
rs1196417432 1778 dbSNP
rs1002005856 1782 dbSNP
rs1446510146 1785 dbSNP
rs2041821 1792 dbSNP
rs375103987 1794 dbSNP
rs1002663540 1795 dbSNP
rs1265131694 1801 dbSNP
rs887157698 1802 dbSNP
rs12897402 1806 dbSNP
rs1351812946 1816 dbSNP
rs892163960 1817 dbSNP
rs543171734 1822 dbSNP
rs191858329 1823 dbSNP
rs530042552 1824 dbSNP
rs942960272 1834 dbSNP
rs912847177 1837 dbSNP
rs1039446764 1839 dbSNP
rs561008822 1840 dbSNP
rs1293533529 1843 dbSNP
rs986929397 1844 dbSNP
rs1298243643 1847 dbSNP
rs186276236 1847 dbSNP
rs575891025 1848 dbSNP
rs1321981330 1863 dbSNP
rs1483368093 1869 dbSNP
rs1320170901 1881 dbSNP
rs1263506504 1885 dbSNP
rs985099217 1891 dbSNP
rs1382757215 1893 dbSNP
rs1263977583 1902 dbSNP
rs1489276830 1911 dbSNP
rs575368743 1912 dbSNP
rs977188377 1917 dbSNP
rs968896675 1919 dbSNP
rs558748598 1923 dbSNP
rs1462818885 1931 dbSNP
rs1021282583 1932 dbSNP
rs919483356 1938 dbSNP
rs1367130547 1940 dbSNP
rs991602385 1957 dbSNP
rs958609014 1960 dbSNP
rs1035579265 1976 dbSNP
rs116302291 1978 dbSNP
rs572931405 1979 dbSNP
rs1371450951 1984 dbSNP
rs747851602 1988 dbSNP
rs1195930250 1990 dbSNP
rs1397457045 1997 dbSNP
rs1310303280 1998 dbSNP
rs1320952103 2002 dbSNP
rs1240613727 2005 dbSNP
rs553054541 2016 dbSNP
rs960664923 2021 dbSNP
rs1351465781 2022 dbSNP
rs1448034922 2024 dbSNP
rs1260272722 2030 dbSNP
rs117430319 2031 dbSNP
rs1183888174 2045 dbSNP
rs1254495004 2047 dbSNP
rs1033754712 2050 dbSNP
rs1179690478 2058 dbSNP
rs1382650373 2059 dbSNP
rs1418460056 2066 dbSNP
rs55734127 2068 dbSNP
rs967944452 2069 dbSNP
rs113703943 2070 dbSNP
rs368238956 2076 dbSNP
rs1039706976 2078 dbSNP
rs942699706 2086 dbSNP
rs891344410 2088 dbSNP
rs1377990355 2111 dbSNP
rs1447201223 2113 dbSNP
rs1311218735 2120 dbSNP
rs537723098 2126 dbSNP
rs1213668663 2129 dbSNP
rs1336853301 2140 dbSNP
rs1239390150 2141 dbSNP
rs1271380150 2147 dbSNP
rs892378124 2165 dbSNP
rs1029558672 2170 dbSNP
rs935463416 2173 dbSNP
rs924088142 2175 dbSNP
rs1199640182 2186 dbSNP
rs899488486 2193 dbSNP
rs1039497315 2194 dbSNP
rs1370070243 2196 dbSNP
rs1426495325 2197 dbSNP
rs1434326876 2213 dbSNP
rs1301170734 2215 dbSNP
rs1173379587 2219 dbSNP
rs941086902 2220 dbSNP
rs1465863206 2223 dbSNP
rs545373557 2230 dbSNP
rs1395035338 2231 dbSNP
rs1445938545 2237 dbSNP
rs1324422087 2239 dbSNP
rs1409661429 2241 dbSNP
rs887986966 2249 dbSNP
rs979629269 2256 dbSNP
rs929467163 2257 dbSNP
rs1323052373 2259 dbSNP
rs1450176275 2265 dbSNP
rs571763152 2269 dbSNP
rs919514943 2281 dbSNP
rs1456672788 2284 dbSNP
rs1204269412 2285 dbSNP
rs1489769351 2286 dbSNP
rs1188930877 2287 dbSNP
rs1428042925 2297 dbSNP
rs1477943101 2302 dbSNP
rs1172446398 2303 dbSNP
rs1421039064 2305 dbSNP
rs992356123 2308 dbSNP
rs939377824 2311 dbSNP
rs947154743 2313 dbSNP
rs760491182 2314 dbSNP
rs1202259965 2319 dbSNP
rs866044137 2322 dbSNP
rs1192369497 2329 dbSNP
rs1455831399 2337 dbSNP
rs968544653 2344 dbSNP
rs991136230 2346 dbSNP
rs915288056 2362 dbSNP
rs1316327137 2369 dbSNP
rs1204292622 2374 dbSNP
rs958626256 2381 dbSNP
rs1035545215 2384 dbSNP
rs1435670947 2385 dbSNP
rs1220095936 2386 dbSNP
rs981304736 2392 dbSNP
rs1267542102 2397 dbSNP
rs1488298801 2399 dbSNP
rs1274677970 2402 dbSNP
rs951326435 2406 dbSNP
rs956539700 2409 dbSNP
rs1025425409 2410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGAUGGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGAUGGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGAUGGGUGGUGGUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | AUAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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