miRTarBase - #MIRT614420


—
pre-miRNA Information
pre-miRNA hsa-mir-4480   
Genomic Coordinates chr10: 12578753 - 12578823
Description Homo sapiens miR-4480 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4480
Sequence 44| AGCCAAGUGGAAGUUACUUUA |64
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 10 + 12578796 23291724, 27587585 MiREDiBase
A-to-I 12 10 + 12578807 23291724, 27587585 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs929437808 7 dbSNP
rs1454494557 9 dbSNP
rs1345041659 17 dbSNP
rs561601367 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF440   
Synonyms -
Description zinc finger protein 440
Transcript NM_152357   
Expression
Putative miRNA Targets on ZNF440
3'UTR of ZNF440
(miRNA target sites are highlighted)		 
>ZNF440|NM_152357|3'UTR
   1 TGCACTCTGTAGAGAGACCTTATAAATGTAAGATATGTGGGAGGGGCTTTTATTCTGCCAAGTCATTTCAAATACATGAA
  81 AAATCTTACACTGGAGAGAAACCCTATGAGTGTAAGCAATGTGGGAAAGCCTTTGTTTCCTTCACTTCCTTTCGATATCA
 161 TGAAAGGACTCACACTGGAGAGAACCCCTATGAGTGTAAGCAATTTGGGAAAGCCTTCAGATCTGTCAAAAATCTTCGAT
 241 TTCATAAAAGGACACACACTGGAGAGAAACCCTGTGAATGTAAGAAATGTAGAAAAGCATTCCATAATTTCTCTTCTTTG
 321 CAAATACATGAAAGGATGCACAGAGGAGAGAAGCTCTGTGAATGTAAGCATTGTGGGAAAGCATTCATATCTGCCAAGAT
 401 CCTTTGAATACATGCAAGAACACACAATGGAGAGAAACCCTATGAATGTAAAGAATGCAGAAAAGCATTCAGCTTGCCTA
 481 CTTCCTTTCATAGACATGAAAAGACTCACACTGGAAGGAAACACTATGAATGCAAGCAATGTGGCAAAGCTTTCACTTCT
 561 TCCAGTTCTTTTCAATATCATGAAAGAACACACTAGGGAGAAACCCTATCAATGTAAGCAATGTGCAAAAGCCTTTATTT
 641 CTTCCACTTCTTTTCAATATCATGAAAGGACTCACATGGGAGAGAAACCCTATGAGTGTATGCCAAGTGGGAAAGCCTTC
 721 ATTTCTTCTAGTTCCCTTCAATATCATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATATAAGCAATGTGGGAAAGC
 801 CTTCAGATCAGCCTCGCACCTTCAAATGCATGGAAGGACTCACACTGGAGAAAAACCCTATGAATGTAAGCAGTATGGGA
 881 AAGCGTTCAGACCTGACAAGATTCTTTGAATACAGATAATGAATGTAAACAATTAACTGTTTATAATAACTGTATACTAA
 961 CAAATGATATTCTTTTTAAATAAGAAGCTATAATATCCCATTGGTGTCATGTATTAGATCAGCCTTATACTGTTAAATTG
1041 TTATTATTTGGACATTGTGAGTCAGTATAACCATGTGGATAAAATGCCAGACATCTTTTTATTCGAAAATTTTACTTTTC
1121 ATGCTTCTGTACTTACATTTTTATCTCAACCTTAATTTTTCTTTCTTTTTTTTTTTCCCCCAGAAAGAATCTCACTCTGT
1201 CACCCAGGCTGGAGTGCAGTGGCATGATCTCAGGTCACTGCAACCTCTGCCTCCAGGGTTCAAGCAATTCTCCTGCCTCA
1281 GTCTCCTGAGTAGCTGGGACTACAGGCATGCGCCACCATGCCAGGCTAATTTTTTGTATTTTTTAGTAGAGACGGGGTTT
1361 CACCATATTGGCTAGGCTGGTCTCAAACTCCAGACCTCATGATTTACCCACCTCGGCCTCCCAAAATGCTGGGATTACAG
1441 ACATGAACCATCATGCCCAGCTGCAACCCTAATTTTTCATTCAGTCATAATACCAATAGTTATCTCATGCACCTCTGAGT
1521 GCCTTCTTCCCCAAAACCAGCAGTGCCATACCTGCTGTCAGCAAGGGTGTAATATACCATAGTGATAAATATGACCAAAA
1601 GCCATAAATGACTGTGAGATGTATGAGAATTACAAGTCACATTAGTAAGAAGAGAAAAATTTTGGTCATGTTTATGATTT
1681 GAAATACGTTTTCCTCTATCACATTTAAAAATATAGTTACAAAATGCCCTTGTTTTTGTCCTGATTCATCATGGTCACTG
1761 AGGAGCATCGTCTCATATGCCTGGTATGTGACACGTGTCTCTCCAACAATAAAAGACTTGGCCTTGGCTGGGCATGGTGG
1841 CTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTCAGGAGTTAGAGACCATTCTGACCAATATGATCAAACCCCGT
1921 CTCTACTAAAAATACAAAAGTTAGCAGGGCGTGGTGGCATGCTCCTGTAATCCTAGCTATTCAGGAGGCTGACATAGGAG
2001 AATTGCTTGAATATAGGAAGCAGAGGTTGCAGTGAGCCGAGGTTGCACCATTGTACTCCAGCCTGGGCAACAAGAGTGAA
2081 ACTCTGTCTTAAAAAACACAAAAAAAGACTTGGCCTTAGGGCCGAGTGCGGTGGCTCACGCCTATAATCCCAGCACTTTG
2161 GGAGGCCGAGGCGGGCGGATCACTAGGTCAGGAAATGGAGACCATCCTGGCCAACACAGTGAAACCCAGTCTCTACT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auuucauugaaggUGAACCGa 5'
                       ||||||| 
Target 5' ccaacaataaaagACTTGGCc 3'
 1803 - 1823 140.00 -8.90
2 
miRNA  3' auuucauugaaggUGAACCGa 5'
                       ||||||| 
Target 5' aacacaaaaaaagACTTGGCc 3'
 2095 - 2115 140.00 -8.90
3 
miRNA  3' auUUCAUUGAAGGUGAACCga 5'
            || | ::| ::|:||||  
Target 5' ttAAATTGTTATTATTTGGac 3'
 1033 - 1053 119.00 -6.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8901225 1 COSMIC
COSN30473127 8 COSMIC
COSN31538606 17 COSMIC
COSN31604090 29 COSMIC
COSN30500511 38 COSMIC
COSN8604942 42 COSMIC
COSN8866754 45 COSMIC
COSN31480923 56 COSMIC
COSN30171661 58 COSMIC
COSN30476633 70 COSMIC
COSN15324674 74 COSMIC
COSN30102058 82 COSMIC
COSN1210806 92 COSMIC
COSN30156704 95 COSMIC
COSN31501727 97 COSMIC
COSN30126342 101 COSMIC
COSN30459046 109 COSMIC
COSN23813880 113 COSMIC
COSN30127595 133 COSMIC
COSN28379296 146 COSMIC
COSN30463811 149 COSMIC
COSN30150930 154 COSMIC
COSN30158611 160 COSMIC
COSN30101925 167 COSMIC
COSN31481657 171 COSMIC
COSN30506441 182 COSMIC
COSN32052695 206 COSMIC
COSN31491146 219 COSMIC
COSN30492991 230 COSMIC
COSN31574515 239 COSMIC
COSN30474335 244 COSMIC
COSN26581743 275 COSMIC
COSN31542212 286 COSMIC
COSN8866755 288 COSMIC
COSN8866756 292 COSMIC
COSN31489826 303 COSMIC
COSN31606658 312 COSMIC
COSN9347699 317 COSMIC
COSN31605574 384 COSMIC
COSN31600165 387 COSMIC
COSN30148928 407 COSMIC
COSN30476413 419 COSMIC
COSN31479673 421 COSMIC
COSN30480287 441 COSMIC
COSN30131011 454 COSMIC
COSN8604943 471 COSMIC
COSN31503087 485 COSMIC
COSN31503058 486 COSMIC
COSN28718761 490 COSMIC
COSN30522771 504 COSMIC
COSN8604944 560 COSMIC
COSN30160307 569 COSMIC
COSN31559096 569 COSMIC
COSN19704312 587 COSMIC
COSN20115450 590 COSMIC
COSN31548081 598 COSMIC
COSN20467438 622 COSMIC
COSN22378324 627 COSMIC
COSN31567154 648 COSMIC
COSN31574752 655 COSMIC
COSN30152290 681 COSMIC
COSN30187943 700 COSMIC
COSN8604945 721 COSMIC
COSN31528907 726 COSMIC
COSN30508785 729 COSMIC
COSN30143941 732 COSMIC
COSN30464611 735 COSMIC
COSN30464603 736 COSMIC
COSN30162359 740 COSMIC
COSN30512820 741 COSMIC
COSN27006122 765 COSMIC
COSN30463430 775 COSMIC
COSN30173471 805 COSMIC
COSN30521470 810 COSMIC
COSN13779992 816 COSMIC
COSN30451244 824 COSMIC
COSN30133047 829 COSMIC
COSN30155317 838 COSMIC
COSN30179642 848 COSMIC
COSN28197961 856 COSMIC
COSN30492068 859 COSMIC
COSN30101076 863 COSMIC
COSN27006121 871 COSMIC
COSN30185529 886 COSMIC
COSN30510956 895 COSMIC
COSN30175582 905 COSMIC
COSN30519153 905 COSMIC
COSN30115748 911 COSMIC
COSN1210807 917 COSMIC
COSN1760389 946 COSMIC
COSN30125120 994 COSMIC
COSN30129350 1044 COSMIC
COSN31602136 1106 COSMIC
COSN31558673 1155 COSMIC
COSN16905757 1177 COSMIC
COSN30128554 1200 COSMIC
COSN15740080 1219 COSMIC
COSN20575765 1248 COSMIC
COSN28627730 1262 COSMIC
COSN31581049 1271 COSMIC
COSN30529086 1313 COSMIC
COSN24050068 1453 COSMIC
COSN26125709 1528 COSMIC
COSN26032509 2161 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1033162799 4 dbSNP
rs770269280 5 dbSNP
rs773693139 6 dbSNP
rs1200519851 7 dbSNP
rs749404632 10 dbSNP
rs771198546 11 dbSNP
rs1169157026 17 dbSNP
rs1391869119 19 dbSNP
rs956379806 25 dbSNP
rs201851810 29 dbSNP
rs1166288798 31 dbSNP
rs1382484652 33 dbSNP
rs1395838862 37 dbSNP
rs1387607376 38 dbSNP
rs146601063 41 dbSNP
rs1355825878 45 dbSNP
rs375049 45 dbSNP
rs368705646 47 dbSNP
rs763792937 48 dbSNP
rs1416963874 49 dbSNP
rs1165070855 50 dbSNP
rs1445085338 51 dbSNP
rs1384342834 63 dbSNP
rs573543742 66 dbSNP
rs3745669 74 dbSNP
rs941730543 79 dbSNP
rs974711512 103 dbSNP
rs1436096614 111 dbSNP
rs1206283152 112 dbSNP
rs375461820 120 dbSNP
rs879060047 135 dbSNP
rs1260261137 141 dbSNP
rs1446994229 150 dbSNP
rs921959667 153 dbSNP
rs141420596 154 dbSNP
rs756909349 155 dbSNP
rs909815985 156 dbSNP
rs1298047585 160 dbSNP
rs1440909493 168 dbSNP
rs1352254969 176 dbSNP
rs939803309 186 dbSNP
rs1424872571 191 dbSNP
rs1364513137 199 dbSNP
rs1046562657 202 dbSNP
rs1175916172 204 dbSNP
rs1408649649 206 dbSNP
rs1412992455 213 dbSNP
rs1036870259 224 dbSNP
rs1176542061 230 dbSNP
rs902689778 238 dbSNP
rs895567789 239 dbSNP
rs763396819 245 dbSNP
rs1053913510 251 dbSNP
rs1156959203 253 dbSNP
rs1218397152 254 dbSNP
rs1044055201 260 dbSNP
rs1384133638 262 dbSNP
rs893778295 272 dbSNP
rs1222532966 273 dbSNP
rs1006919162 277 dbSNP
rs533414503 281 dbSNP
rs430965 288 dbSNP
rs381973 292 dbSNP
rs1404122057 293 dbSNP
rs1300841046 299 dbSNP
rs1033649925 309 dbSNP
rs892055262 317 dbSNP
rs1455209082 329 dbSNP
rs199519108 336 dbSNP
rs1030114927 340 dbSNP
rs527833553 343 dbSNP
rs1398858599 346 dbSNP
rs950593585 355 dbSNP
rs1352016066 357 dbSNP
rs549200522 364 dbSNP
rs1480113469 370 dbSNP
rs1267106582 374 dbSNP
rs567677716 378 dbSNP
rs531628221 382 dbSNP
rs1236243530 384 dbSNP
rs1486420911 388 dbSNP
rs1019110201 391 dbSNP
rs550113661 399 dbSNP
rs966090285 401 dbSNP
rs569182679 409 dbSNP
rs1214024925 410 dbSNP
rs182973630 411 dbSNP
rs558027434 413 dbSNP
rs541302419 415 dbSNP
rs187351202 416 dbSNP
rs1298826572 417 dbSNP
rs963471821 432 dbSNP
rs909754495 440 dbSNP
rs1294615111 443 dbSNP
rs533919482 448 dbSNP
rs555149884 478 dbSNP
rs1408217316 479 dbSNP
rs573653730 481 dbSNP
rs949581415 487 dbSNP
rs543882910 491 dbSNP
rs10411874 492 dbSNP
rs1429357379 500 dbSNP
rs1179710737 504 dbSNP
rs1185144770 510 dbSNP
rs1462887380 511 dbSNP
rs924101295 512 dbSNP
rs749658756 521 dbSNP
rs192651852 524 dbSNP
rs1322271947 527 dbSNP
rs1164863129 532 dbSNP
rs927077495 533 dbSNP
rs1363640105 537 dbSNP
rs1423757501 538 dbSNP
rs545293677 540 dbSNP
rs434048 544 dbSNP
rs892043488 545 dbSNP
rs1384720420 550 dbSNP
rs1389362737 556 dbSNP
rs1451798263 566 dbSNP
rs1010476437 574 dbSNP
rs1040505691 577 dbSNP
rs1462499102 578 dbSNP
rs1372731941 581 dbSNP
rs902041289 583 dbSNP
rs1168588165 586 dbSNP
rs34722409 589 dbSNP
rs35549963 590 dbSNP
rs996375548 590 dbSNP
rs901218459 592 dbSNP
rs1460390516 598 dbSNP
rs1253238610 601 dbSNP
rs1062257 613 dbSNP
rs1029460643 614 dbSNP
rs1030229388 620 dbSNP
rs1062258 622 dbSNP
rs1275846413 624 dbSNP
rs868069415 625 dbSNP
rs1004691096 628 dbSNP
rs1016530338 633 dbSNP
rs1392090784 638 dbSNP
rs1006633300 643 dbSNP
rs1014962142 646 dbSNP
rs961272962 647 dbSNP
rs1306451428 651 dbSNP
rs990983304 660 dbSNP
rs972669955 661 dbSNP
rs1189784513 668 dbSNP
rs917188863 671 dbSNP
rs1366379594 672 dbSNP
rs1383287198 674 dbSNP
rs543176786 678 dbSNP
rs138342575 679 dbSNP
rs979967034 685 dbSNP
rs1419192158 688 dbSNP
rs531789948 693 dbSNP
rs1168960930 698 dbSNP
rs1372136822 702 dbSNP
rs1062259 707 dbSNP
rs1353974555 711 dbSNP
rs1460297436 712 dbSNP
rs1239645287 713 dbSNP
rs1062260 735 dbSNP
rs1062262 737 dbSNP
rs1335304238 738 dbSNP
rs550199788 740 dbSNP
rs1297189889 742 dbSNP
rs1062264 744 dbSNP
rs935804570 747 dbSNP
rs1346393879 753 dbSNP
rs1054519971 762 dbSNP
rs565272890 763 dbSNP
rs912926247 773 dbSNP
rs533303724 777 dbSNP
rs1404011578 778 dbSNP
rs1062265 783 dbSNP
rs1159702068 787 dbSNP
rs1397265772 791 dbSNP
rs1062266 793 dbSNP
rs1062267 794 dbSNP
rs1179389328 801 dbSNP
rs946282459 810 dbSNP
rs1481096849 813 dbSNP
rs1269223239 815 dbSNP
rs942793858 816 dbSNP
rs1062268 817 dbSNP
rs1205457163 820 dbSNP
rs1349915405 827 dbSNP
rs1062269 830 dbSNP
rs1040577788 833 dbSNP
rs902114917 842 dbSNP
rs1062271 853 dbSNP
rs934023329 854 dbSNP
rs1282958515 857 dbSNP
rs532572212 869 dbSNP
rs551683290 876 dbSNP
rs1319426012 884 dbSNP
rs1309570371 885 dbSNP
rs1062272 886 dbSNP
rs1179188126 893 dbSNP
rs1250961988 902 dbSNP
rs899028253 903 dbSNP
rs1429345186 905 dbSNP
rs1012000270 915 dbSNP
rs1006337540 921 dbSNP
rs1483731996 925 dbSNP
rs552160977 926 dbSNP
rs1014917014 928 dbSNP
rs1023411307 944 dbSNP
rs549129445 950 dbSNP
rs970366467 951 dbSNP
rs567260743 955 dbSNP
rs981744222 972 dbSNP
rs1241406249 973 dbSNP
rs187602664 978 dbSNP
rs1013606163 980 dbSNP
rs1262614179 1003 dbSNP
rs1024195995 1006 dbSNP
rs1217507308 1011 dbSNP
rs1341741137 1037 dbSNP
rs971341437 1041 dbSNP
rs980339040 1045 dbSNP
rs927182483 1049 dbSNP
rs957333376 1050 dbSNP
rs956945538 1053 dbSNP
rs1421585513 1058 dbSNP
rs1426450455 1062 dbSNP
rs1405933254 1068 dbSNP
rs1332971640 1073 dbSNP
rs1412206644 1074 dbSNP
rs1421222687 1075 dbSNP
rs1168124253 1090 dbSNP
rs1448717145 1091 dbSNP
rs989938586 1092 dbSNP
rs929645364 1095 dbSNP
rs1388058473 1105 dbSNP
rs555787085 1106 dbSNP
rs2545809 1111 dbSNP
rs1236758919 1122 dbSNP
rs1208121826 1125 dbSNP
rs598006 1128 dbSNP
rs1274062555 1137 dbSNP
rs1204661516 1143 dbSNP
rs1435202904 1146 dbSNP
rs975724922 1151 dbSNP
rs1321729432 1152 dbSNP
rs922659254 1154 dbSNP
rs1247123480 1158 dbSNP
rs1380869208 1159 dbSNP
rs1382702528 1162 dbSNP
rs879459868 1166 dbSNP
rs934097047 1166 dbSNP
rs1355771493 1170 dbSNP
rs1329177640 1171 dbSNP
rs773373526 1175 dbSNP
rs1491451617 1176 dbSNP
rs554065293 1177 dbSNP
rs940609886 1177 dbSNP
rs1413053889 1178 dbSNP
rs572664196 1200 dbSNP
rs74181615 1211 dbSNP
rs1233501605 1218 dbSNP
rs1312966516 1227 dbSNP
rs561484904 1238 dbSNP
rs565674771 1241 dbSNP
rs1322841699 1250 dbSNP
rs1294139423 1254 dbSNP
rs942212013 1262 dbSNP
rs1044931047 1263 dbSNP
rs543922143 1278 dbSNP
rs1036420333 1283 dbSNP
rs878908357 1284 dbSNP
rs1288436027 1286 dbSNP
rs1225946974 1294 dbSNP
rs1279659371 1297 dbSNP
rs769768054 1299 dbSNP
rs1484886570 1303 dbSNP
rs1304563695 1304 dbSNP
rs113333129 1312 dbSNP
rs532526306 1313 dbSNP
rs1162654301 1314 dbSNP
rs1402396657 1318 dbSNP
rs907106760 1320 dbSNP
rs1001488313 1322 dbSNP
rs201408980 1324 dbSNP
rs1034576964 1330 dbSNP
rs1481307314 1337 dbSNP
rs957202202 1350 dbSNP
rs1200413859 1352 dbSNP
rs547786078 1354 dbSNP
rs192616555 1355 dbSNP
rs1218333647 1356 dbSNP
rs1267987664 1368 dbSNP
rs1318050081 1368 dbSNP
rs1160727566 1374 dbSNP
rs1407462091 1376 dbSNP
rs1347438671 1385 dbSNP
rs1452312663 1386 dbSNP
rs1366407399 1398 dbSNP
rs1291603713 1409 dbSNP
rs1288833557 1412 dbSNP
rs967141189 1413 dbSNP
rs975714835 1415 dbSNP
rs1011142346 1416 dbSNP
rs1431507032 1419 dbSNP
rs1022999690 1433 dbSNP
rs1281541141 1435 dbSNP
rs548862984 1440 dbSNP
rs975530130 1441 dbSNP
rs1486388256 1444 dbSNP
rs1229068396 1450 dbSNP
rs922776847 1454 dbSNP
rs955422763 1456 dbSNP
rs1315231543 1458 dbSNP
rs1311257627 1459 dbSNP
rs568605271 1462 dbSNP
rs986376365 1465 dbSNP
rs1365660867 1474 dbSNP
rs1319858410 1478 dbSNP
rs1490759750 1483 dbSNP
rs2685659 1488 dbSNP
rs941382171 1493 dbSNP
rs942179024 1500 dbSNP
rs1465555797 1505 dbSNP
rs567452633 1508 dbSNP
rs537590406 1511 dbSNP
rs1172793387 1514 dbSNP
rs184835577 1518 dbSNP
rs369357896 1522 dbSNP
rs4594364 1524 dbSNP
rs549450843 1532 dbSNP
rs1187012494 1534 dbSNP
rs920476543 1544 dbSNP
rs1178396658 1545 dbSNP
rs897909103 1546 dbSNP
rs1418028057 1548 dbSNP
rs761407598 1549 dbSNP
rs1253946867 1551 dbSNP
rs949481564 1557 dbSNP
rs1046417660 1560 dbSNP
rs1342673873 1565 dbSNP
rs905214014 1575 dbSNP
rs1044879692 1581 dbSNP
rs1158946665 1605 dbSNP
rs1002632681 1622 dbSNP
rs1233887034 1632 dbSNP
rs1294588341 1636 dbSNP
rs1225852309 1655 dbSNP
rs555846173 1657 dbSNP
rs1313327365 1660 dbSNP
rs1366742557 1661 dbSNP
rs1400114083 1662 dbSNP
rs1426943947 1668 dbSNP
rs745886944 1673 dbSNP
rs1167102377 1686 dbSNP
rs2545808 1688 dbSNP
rs116557162 1689 dbSNP
rs1052641199 1697 dbSNP
rs1422774652 1699 dbSNP
rs892119819 1705 dbSNP
rs600636 1709 dbSNP
rs1021979886 1712 dbSNP
rs1020109878 1714 dbSNP
rs1202830087 1717 dbSNP
rs1361319189 1721 dbSNP
rs558304048 1733 dbSNP
rs1487014459 1734 dbSNP
rs766896471 1739 dbSNP
rs1361571865 1742 dbSNP
rs1030514610 1758 dbSNP
rs997064197 1761 dbSNP
rs1309277325 1763 dbSNP
rs953045745 1766 dbSNP
rs1029776940 1768 dbSNP
rs1219942658 1769 dbSNP
rs536946040 1770 dbSNP
rs189979569 1771 dbSNP
rs1163243599 1773 dbSNP
rs963663253 1776 dbSNP
rs1456863606 1782 dbSNP
rs1366018757 1787 dbSNP
rs1472623808 1791 dbSNP
rs576562587 1795 dbSNP
rs571986688 1796 dbSNP
rs559118220 1804 dbSNP
rs191774196 1807 dbSNP
rs1208977164 1808 dbSNP
rs1354169443 1818 dbSNP
rs199581298 1824 dbSNP
rs1328573892 1828 dbSNP
rs1230836278 1844 dbSNP
rs146110646 1847 dbSNP
rs1323349438 1855 dbSNP
rs1385389981 1861 dbSNP
rs184691397 1862 dbSNP
rs1386396044 1863 dbSNP
rs527635228 1865 dbSNP
rs1410550730 1874 dbSNP
rs1156255822 1875 dbSNP
rs1486281155 1875 dbSNP
rs1478823811 1880 dbSNP
rs1162023761 1881 dbSNP
rs1384947556 1885 dbSNP
rs1410892183 1886 dbSNP
rs1331058741 1888 dbSNP
rs1054197381 1903 dbSNP
rs1353043100 1908 dbSNP
rs542897808 1909 dbSNP
rs1449643325 1914 dbSNP
rs140140614 1919 dbSNP
rs1041516406 1920 dbSNP
rs1243622235 1925 dbSNP
rs903003052 1929 dbSNP
rs1266345121 1931 dbSNP
rs1314326566 1934 dbSNP
rs1225390894 1949 dbSNP
rs892186237 1951 dbSNP
rs997318250 1952 dbSNP
rs374410208 1955 dbSNP
rs1231612599 1957 dbSNP
rs764609132 1960 dbSNP
rs531381747 1977 dbSNP
rs1030047477 1986 dbSNP
rs1043753536 1987 dbSNP
rs188915899 1992 dbSNP
rs367971465 1995 dbSNP
rs1160057468 1996 dbSNP
rs1317962849 1999 dbSNP
rs1415625322 2016 dbSNP
rs1402540373 2020 dbSNP
rs1171637627 2026 dbSNP
rs1476943178 2033 dbSNP
rs899541817 2034 dbSNP
rs1188913375 2035 dbSNP
rs1448828428 2039 dbSNP
rs571017109 2040 dbSNP
rs1212356614 2043 dbSNP
rs1443066554 2045 dbSNP
rs1278233040 2046 dbSNP
rs1210181599 2048 dbSNP
rs1016376539 2051 dbSNP
rs1341672137 2053 dbSNP
rs1275837196 2055 dbSNP
rs775027468 2057 dbSNP
rs1244488337 2072 dbSNP
rs1363658874 2073 dbSNP
rs1459608095 2077 dbSNP
rs1317760044 2082 dbSNP
rs1182220646 2091 dbSNP
rs1365767064 2091 dbSNP
rs1449672074 2097 dbSNP
rs1243075085 2098 dbSNP
rs1340518260 2100 dbSNP
rs1475942814 2100 dbSNP
rs963608273 2115 dbSNP
rs1170061130 2118 dbSNP
rs1412423015 2120 dbSNP
rs1371982596 2123 dbSNP
rs1417606477 2124 dbSNP
rs997051333 2125 dbSNP
rs1029893438 2127 dbSNP
rs1409646132 2127 dbSNP
rs370675948 2130 dbSNP
rs919526036 2131 dbSNP
rs532030919 2132 dbSNP
rs541007397 2135 dbSNP
rs1450565333 2138 dbSNP
rs181934923 2140 dbSNP
rs982694167 2141 dbSNP
rs565658477 2143 dbSNP
rs938129640 2145 dbSNP
rs963077210 2146 dbSNP
rs186354564 2162 dbSNP
rs1445090948 2165 dbSNP
rs974190988 2168 dbSNP
rs536574731 2169 dbSNP
rs915269065 2173 dbSNP
rs144017238 2174 dbSNP
rs1243055998 2177 dbSNP
rs927839813 2178 dbSNP
rs939267837 2179 dbSNP
rs1041587825 2181 dbSNP
rs903115939 2184 dbSNP
rs1482307690 2186 dbSNP
rs1248845662 2203 dbSNP
rs1222725334 2209 dbSNP
rs997266326 2210 dbSNP
rs1288283266 2213 dbSNP
rs1052073097 2218 dbSNP
rs888863257 2219 dbSNP
rs1330601611 2220 dbSNP
rs1007748834 2221 dbSNP
rs913743677 2227 dbSNP
rs1227421058 2236 dbSNP
rs1348194672 2238 dbSNP
rs1295072080 2239 dbSNP
rs112524698 2247 dbSNP
rs1349284189 2247 dbSNP
rs946451895 2252 dbSNP
rs1015912617 2253 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000304060.5 | 3UTR | AAAAAAAAAAAAAAAAAAGACUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
117 hsa-miR-4480 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056040 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT091259 FXR1 FMR1 autosomal homolog 1 2 4
MIRT117347 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT234960 ZNF439 zinc finger protein 439 2 4
MIRT441356 ZNF75A zinc finger protein 75a 2 2
MIRT441426 STXBP2 syntaxin binding protein 2 2 2
MIRT441455 ZNF488 zinc finger protein 488 2 4
MIRT441524 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT441576 EXOC5 exocyst complex component 5 2 2
MIRT441597 ABCB5 ATP binding cassette subfamily B member 5 2 6
MIRT441610 ATP13A4 ATPase 13A4 2 2
MIRT441698 CIT citron rho-interacting serine/threonine kinase 2 2
MIRT441714 FGF9 fibroblast growth factor 9 2 2
MIRT441784 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT441795 EXOSC2 exosome component 2 2 2
MIRT441868 RNASEL ribonuclease L 2 2
MIRT441900 SLC9A8 solute carrier family 9 member A8 2 6
MIRT441919 FAM217B family with sequence similarity 217 member B 2 2
MIRT441928 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT441938 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT442157 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT442172 AZF1 azoospermia factor 1 2 2
MIRT442208 IRS1 insulin receptor substrate 1 2 2
MIRT442237 DDX19A DEAD-box helicase 19A 2 2
MIRT442366 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT442572 SDC1 syndecan 1 2 2
MIRT442604 ZNF391 zinc finger protein 391 2 2
MIRT442609 MRC1 mannose receptor C-type 1 2 2
MIRT442647 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT442658 OIP5 Opa interacting protein 5 2 6
MIRT442686 COX15 COX15, cytochrome c oxidase assembly homolog 2 2
MIRT442773 JAG1 jagged 1 2 2
MIRT442785 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT442895 PLCB3 phospholipase C beta 3 2 2
MIRT442941 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT442959 SGCD sarcoglycan delta 2 2
MIRT442998 EDAR ectodysplasin A receptor 2 2
MIRT443017 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT443064 CASP5 caspase 5 2 2
MIRT443069 ABLIM1 actin binding LIM protein 1 2 2
MIRT443208 VPS36 vacuolar protein sorting 36 homolog 2 2
MIRT443237 ANKRD26 ankyrin repeat domain 26 2 2
MIRT443253 A1CF APOBEC1 complementation factor 2 2
MIRT443329 JUN Jun proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT443333 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT443349 STX7 syntaxin 7 2 2
MIRT443452 CLIC5 chloride intracellular channel 5 2 2
MIRT443547 GPR35 G protein-coupled receptor 35 2 2
MIRT443616 AVPR1A arginine vasopressin receptor 1A 2 2
MIRT443626 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT443730 ALPK3 alpha kinase 3 2 2
MIRT443786 ST13 ST13, Hsp70 interacting protein 2 2
MIRT443852 RGS6 regulator of G protein signaling 6 2 2
MIRT445483 KLF5 Kruppel like factor 5 2 2
MIRT471105 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT472329 NETO2 neuropilin and tolloid like 2 2 4
MIRT472391 NDRG3 NDRG family member 3 2 2
MIRT473522 MAX MYC associated factor X 2 2
MIRT473874 MAFK MAF bZIP transcription factor K 2 6
MIRT476021 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT478320 DDN dendrin 2 2
MIRT492049 TNFSF9 TNF superfamily member 9 2 2
MIRT494851 ANKRD24 ankyrin repeat domain 24 2 2
MIRT494991 TSSC1 EARP complex and GARP complex interacting protein 1 2 2
MIRT495034 RASSF2 Ras association domain family member 2 2 2
MIRT495111 NOL10 nucleolar protein 10 2 2
MIRT495113 TRADD TNFRSF1A associated via death domain 2 2
MIRT495131 METTL24 methyltransferase like 24 2 2
MIRT495147 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT495297 NUP54 nucleoporin 54 2 2
MIRT495341 RTN2 reticulon 2 2 2
MIRT495347 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT496682 DUSP18 dual specificity phosphatase 18 2 2
MIRT496743 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT496841 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT496852 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2 2
MIRT496889 FOXP1 forkhead box P1 2 2
MIRT496922 CLMN calmin 2 2
MIRT496990 TMEM231 transmembrane protein 231 2 2
MIRT497002 SNAP25 synaptosome associated protein 25 2 2
MIRT497058 C6orf223 chromosome 6 open reading frame 223 2 2
MIRT500529 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 6
MIRT506048 PPP6C protein phosphatase 6 catalytic subunit 2 4
MIRT512163 CD164 CD164 molecule 2 6
MIRT527051 RDH13 retinol dehydrogenase 13 2 2
MIRT532282 TNFSF14 TNF superfamily member 14 2 2
MIRT534083 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT534605 RNASEH1 ribonuclease H1 2 4
MIRT539509 ACSS3 acyl-CoA synthetase short chain family member 3 2 2
MIRT543069 ARID4B AT-rich interaction domain 4B 2 2
MIRT544233 CCBL2 kynurenine aminotransferase 3 2 2
MIRT544686 ZNF224 zinc finger protein 224 2 4
MIRT546269 TMEM30A transmembrane protein 30A 2 4
MIRT559069 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT562768 RMI2 RecQ mediated genome instability 2 2 2
MIRT563974 HCFC1 host cell factor C1 2 2
MIRT564086 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT564525 PDXP pyridoxal phosphatase 2 2
MIRT564613 ZNF703 zinc finger protein 703 2 2
MIRT566252 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT614420 ZNF440 zinc finger protein 440 2 2
MIRT618789 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT619160 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT641778 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT653680 SLC25A36 solute carrier family 25 member 36 2 2
MIRT657861 GJD2 gap junction protein delta 2 2 2
MIRT660879 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT668781 DAAM1 dishevelled associated activator of morphogenesis 1 2 4
MIRT688559 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT695393 WDR41 WD repeat domain 41 2 2
MIRT698680 TCEA1 transcription elongation factor A1 2 2
MIRT700974 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT705055 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705864 AFF1 AF4/FMR2 family member 1 2 2
MIRT710586 CDCA4 cell division cycle associated 4 2 2
MIRT713904 IGF2R insulin like growth factor 2 receptor 2 2
MIRT717133 SKI SKI proto-oncogene 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4480 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-4480 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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