pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BCL7A   
Synonyms BCL7
Description BCL tumor suppressor 7A
Transcript NM_001024808   
Other Transcripts NM_020993   
Expression
Putative miRNA Targets on BCL7A
3'UTR of BCL7A
(miRNA target sites are highlighted)
>BCL7A|NM_001024808|3'UTR
   1 ACGATGCTTTAAAGCCTCCGATCCATGTTCCATGGAAGGTACATCAGCAATTAATTCTAGAGCAACTTTGCCCCAGCGAT
  81 TCCTCTTGGGTGCGAACAGAACTACTAACGTTTCAAGTTTACCAAGTGCAAATCCAAGAAGACCCAGAACGGCGTCACTT
 161 CTCAGACACTGAAGAACTCTGCTGTGAAGCAAAACACTCAAACCTTTAAGGGACTGTCCTTGGGGAGGCAGGCGGGGCTG
 241 ACAGCTCAGGAGTGTCTGCACACTGTCTCGGAAGCCAGGATTCCATTTGTGTTGCTGCTGTATTTTCCCCCCACTTCTCT
 321 ATGTAACGATATAAGCTATCGGAGGGTGGTACCGATCAGGAACGCTTTTTGGCGGGGCTTTCCACTGTTCAACCGATTCC
 401 TTCCGCTTTCTTTTTTTGTGCCTTGTGCCCTTGAGGTGACCTCTGGCATGTATCCTGGTGGTTCTTACATCCCCCTCTGC
 481 AAAGTGCCCTCTTGGTTTGGTTCGGGCGGCGGCTGCCACCCTACTCACCGCTCTCCTCCCTGCCCCAGGACTTCATCGGA
 561 GCAGGCAGGGTGGAGCGAAGGAGCTCCTTAGCCCACCTGGTTTGCAGGTGCAGGGGGACCTTAGGCACGCCCCAAGCACC
 641 AGGCACCAGGGCCCAAGGACGCGCAGGTGTTGGGGCACAGTCCCCAAGGGCTCGGCCCCTTGGATCAGGCTGGGCACTCG
 721 CTGTGCTCTCCCCTCCTTGGGGCGTTTAGGACTGGGCGTCTCCAAGCCCACCATGGCCCAGATGGACGTGCAAAGCCCTT
 801 GGAATTTTCTGGCACTTCCTCTCTATTGCCCCCACCACCACCACCCCCATCACTGCTTTCTCCCAGACCTCCGAATACGA
 881 AATGGCTTCTCTGGCTGACTGCAAGGCTGTCTCCTTAAGGCACTGAGTGGGCCGGGGAGGCTGGGAGCCGGCGGCAGGAT
 961 TAGCTGGTGCTGAACTTTCTCTCATAGGACGTCGCTTGGATTTCAAATCCACGGTCACCTGCTGCCCTTTGCCTCCCCCG
1041 ACGCCCCAGCCTGTGCCCCGGAGAGGCAGGATCGCAGTGGTCAGAATCCACGTGCTTTCCTATTCTCAGGCTGTTCTGAC
1121 TCTGAGCCAACAGCTGGACCGTGTCTCATCCCCAGAACATGCCGTCTGTCCCCACCGGGGAGTGGGCCTTGATGGCCGGG
1201 CCTCGAAGGCCACAAACAAGGCGTCGAGGAATTGGAAAGATTTGCACACCCTCCAGAAAGGAGAGACGCAATCTCCCCTC
1281 CCTCCCATCCCCCACCTTCGCTGGAACAGCTTCCTCTCACTGAACGGAGACGCCCCCTTGGACGAACTGCCTAATCGTTT
1361 GGTTCTGAGGCCTGGTTTGCTCTTAATTAATATATGAACTCCTCAGACCTTAAACCTTTTCCTAAGCTTTCTTTACTGCA
1441 CTGGAGTTCTGACTCCCTTTGAGTTGTGTGTTACTGGGGGTGGGGTGGGGTCATGGGTTTTGTTGTTTTTGGGGGCTAAT
1521 TGGTGCATATTCAGGTACCACCTTTGACGTGTGGCTCTTTCTCCTGACCATCATGGGAAGTGTCTGCTGGATTCCATTTT
1601 CTAAGAGTTTCTGAGGGTGAGGCTCTTATTTTTTTTTTTAAGGGATCCTGTCTATTTCCTGCACTTCGAGAAGAATCAAA
1681 ATGTTCCTGAATTTCAAATACCTCATGCAAAATGTCTCCTGAAATAAGGGAAAAAAAAAAAACCACAACTTTGAAAATCT
1761 TAATGTTGAAGTTAGCAATGCCGAAAGGTTTCTGTCTTAAAAAAAAAAATCCTTGTACTTATCAATTTTGCCCCTTAGGC
1841 AGTCAGTTTTGTTGAGAACTGTGTCCTGCATCCTGGCGCAGAACCTACCTGATGCGGTTCCTCTCCACGCATCTCGAGGC
1921 GGCGTTACCTCCAGATTCCGTAGAGTTAGAGTCACATTTTTCTTTGCAGCGAAACTCCATCTTGGTGAGAGATGAATTTG
2001 GATATTTATTTCCTTCTCTGTTTTTGGGAAACGAGAGGCTACAACCAAGACAGCTGAAGGAGAATGAAACACACACATCC
2081 ACAGAAACAGAGAGGCGTAGGTGGCCCTGCCGTTGACCGCAGCCTCTCTGGACAGGCAAGGGGAGTTGGCGCAGGTGAGG
2161 ACTCAGACGACGTCCACCGTCCCAAGGCTGTCACTAGTATTTCTCTGAAGTGCCTGAAGGTAGGAATGGGCCGGCGATTG
2241 GGACCAGCTGGGCCCCACCACGGCCACGCCAGGCAAAGCGCCAGCAGCCCTGCACTCCACGCTGGCCAAGAAGGCCTTCC
2321 ACGCAGAATGACAAGACTGCAAAAATCCGATGTGCTTCCTTCCCTGGCGCAGTCGCTCCTCGAGCCGCTGCCCCCCACCC
2401 ACCCTGCACCCCTCGCCCTCCCCCCACCACAGAATCTAAGACCTTTCAGCTTCGAGCCAGGGGGCGGGGGATCCCGAGCA
2481 AAAGCCTTCCGTGGACATCAGGCCCCGTGGCCTCAAGGGCTCCCAGGGCAAACCTAATTCCCCCCAAAACGTGAAGTCGG
2561 GGAAGCTGCGGCTACACATTCCACAAAGTGCTGGCACTTACACCCACAACCCGGAAGGCTGTGGACCGATTCCTCTAGGG
2641 TGGTGACCTCCCATTAGCAAACGGTGTCATGGTTTGGAATGTTCATTATCGCCAAGAACCTGGTTAGAGGCATAAAGACC
2721 TTTTTTCACCGTTACCTAATTTTTTCCCCTTTCAAGAATTTTTTTTTTTTTTGGTGTGTTGTACAGCAGTATAATTTTTC
2801 ACTTATTTATTCCATCAGTAGATATGGTTTGTACAATGTACAATTGTTTCATTTCAGAAAATAAAAATTTCAAATCATGA
2881 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguucCCUUACCGUCCCUUUa 5'
                | |||   ||||||| 
Target 5' tctcctGAAAT--AAGGGAAAa 3'
1715 - 1734 144.00 -10.60
2
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            ||||||  |  ||||| || 
Target 5' ctCAAGGG-CTCCCAGGGCAAa 3'
2512 - 2532 131.00 -17.50
3
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            || ||  | | |||| ||| 
Target 5' acCACGGCCACGCCAGGCAAAg 3'
2257 - 2278 128.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30500251 3 COSMIC
COSN30158254 17 COSMIC
COSN30465889 21 COSMIC
COSN30496907 23 COSMIC
COSN26967785 24 COSMIC
COSN31554217 76 COSMIC
COSN27694641 198 COSMIC
COSN20046861 213 COSMIC
COSN19408203 235 COSMIC
COSN25091332 613 COSMIC
COSN31769742 654 COSMIC
COSN31488756 822 COSMIC
COSN26678078 926 COSMIC
COSN28727499 934 COSMIC
COSN8698391 988 COSMIC
COSN7610076 1041 COSMIC
COSN31591028 1093 COSMIC
COSN10099561 1198 COSMIC
COSN31769743 1218 COSMIC
COSN30539781 1281 COSMIC
COSN8585496 1483 COSMIC
COSN31522054 1640 COSMIC
COSN26573757 1656 COSMIC
COSN26572526 1732 COSMIC
COSN31487299 1784 COSMIC
COSN31546405 1827 COSMIC
COSN27667097 2080 COSMIC
COSN31489549 2490 COSMIC
COSN31769745 2711 COSMIC
COSN31523256 2719 COSMIC
COSN31769746 2721 COSMIC
COSN26648228 2731 COSMIC
COSN30173434 2754 COSMIC
COSN19661208 2765 COSMIC
COSN20110255 2773 COSMIC
COSN22590304 2814 COSMIC
rs28384349 934 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs550091216 3 dbSNP
rs755848366 4 dbSNP
rs562062691 5 dbSNP
rs1455155770 8 dbSNP
rs529033756 9 dbSNP
rs368258721 15 dbSNP
rs774282210 20 dbSNP
rs372266845 21 dbSNP
rs1183156847 27 dbSNP
rs772036219 32 dbSNP
rs773380784 33 dbSNP
rs945994998 34 dbSNP
rs1309781929 36 dbSNP
rs1051485416 40 dbSNP
rs760785150 41 dbSNP
rs1373498450 42 dbSNP
rs777093755 44 dbSNP
rs373993754 48 dbSNP
rs765756172 50 dbSNP
rs959511538 58 dbSNP
rs1278949390 63 dbSNP
rs564084558 66 dbSNP
rs1378937206 69 dbSNP
rs773315385 70 dbSNP
rs1342722403 78 dbSNP
rs918098606 79 dbSNP
rs763719414 83 dbSNP
rs191030948 86 dbSNP
rs532821694 87 dbSNP
rs951666204 91 dbSNP
rs1250154384 94 dbSNP
rs907538282 95 dbSNP
rs1183253195 99 dbSNP
rs1442085808 100 dbSNP
rs773170697 100 dbSNP
rs566007663 101 dbSNP
rs771142155 106 dbSNP
rs774375307 117 dbSNP
rs1213895048 118 dbSNP
rs1446583093 123 dbSNP
rs1283302021 124 dbSNP
rs1240554283 126 dbSNP
rs992421020 144 dbSNP
rs1025673311 148 dbSNP
rs1037563092 151 dbSNP
rs900403666 152 dbSNP
rs1367687311 155 dbSNP
rs1477307373 185 dbSNP
rs1169192962 193 dbSNP
rs1428227265 202 dbSNP
rs539569491 204 dbSNP
rs1344167571 205 dbSNP
rs1390239321 212 dbSNP
rs1421850408 218 dbSNP
rs1374219133 221 dbSNP
rs1454811052 224 dbSNP
rs879422015 234 dbSNP
rs980190310 235 dbSNP
rs1475227564 236 dbSNP
rs1052000409 237 dbSNP
rs759570962 238 dbSNP
rs1242867198 239 dbSNP
rs879517274 243 dbSNP
rs890299253 248 dbSNP
rs1008726933 252 dbSNP
rs927024284 255 dbSNP
rs1489130324 265 dbSNP
rs1021073050 270 dbSNP
rs966690634 271 dbSNP
rs1210055895 272 dbSNP
rs935757371 279 dbSNP
rs1302768330 283 dbSNP
rs1387155751 284 dbSNP
rs1360860410 290 dbSNP
rs1322600044 291 dbSNP
rs1000893801 292 dbSNP
rs1402321599 300 dbSNP
rs1353941369 303 dbSNP
rs1329314953 304 dbSNP
rs1032364187 306 dbSNP
rs959576850 307 dbSNP
rs1361368731 308 dbSNP
rs1168455445 311 dbSNP
rs913057044 313 dbSNP
rs78067163 315 dbSNP
rs918074560 322 dbSNP
rs569702350 323 dbSNP
rs537091593 328 dbSNP
rs1186872273 329 dbSNP
rs1483553509 338 dbSNP
rs1257635563 339 dbSNP
rs1358680208 341 dbSNP
rs1210847152 342 dbSNP
rs983593435 354 dbSNP
rs767382611 355 dbSNP
rs761501744 356 dbSNP
rs1220106448 357 dbSNP
rs1450451704 359 dbSNP
rs1353112078 364 dbSNP
rs941801973 365 dbSNP
rs1396927956 368 dbSNP
rs775190078 374 dbSNP
rs898542319 375 dbSNP
rs995598128 377 dbSNP
rs1401106268 382 dbSNP
rs1249116743 387 dbSNP
rs921613083 395 dbSNP
rs749038387 396 dbSNP
rs1025773923 401 dbSNP
rs1163829733 404 dbSNP
rs1051725778 405 dbSNP
rs1175403971 406 dbSNP
rs1258265296 406 dbSNP
rs1480237241 411 dbSNP
rs890278794 412 dbSNP
rs1199939999 422 dbSNP
rs1332253677 423 dbSNP
rs1186064155 429 dbSNP
rs945932781 438 dbSNP
rs1042479475 458 dbSNP
rs1246036880 460 dbSNP
rs1014201242 462 dbSNP
rs902579002 466 dbSNP
rs1223725878 469 dbSNP
rs1378209290 475 dbSNP
rs1333478741 476 dbSNP
rs760353756 480 dbSNP
rs965265863 500 dbSNP
rs1025197129 502 dbSNP
rs970064126 504 dbSNP
rs1032303685 505 dbSNP
rs376855615 508 dbSNP
rs555735343 509 dbSNP
rs763712452 511 dbSNP
rs1012903250 512 dbSNP
rs73417628 517 dbSNP
rs1466726333 519 dbSNP
rs1266317340 521 dbSNP
rs913004679 524 dbSNP
rs971286105 527 dbSNP
rs1489224099 529 dbSNP
rs983614090 530 dbSNP
rs1015058409 531 dbSNP
rs963063336 534 dbSNP
rs1370324067 536 dbSNP
rs1295448403 537 dbSNP
rs1464421842 541 dbSNP
rs1302005024 545 dbSNP
rs534870769 555 dbSNP
rs973130883 558 dbSNP
rs1265292553 559 dbSNP
rs942614487 565 dbSNP
rs921600990 566 dbSNP
rs1452090935 574 dbSNP
rs1376586839 575 dbSNP
rs931701579 576 dbSNP
rs987781672 577 dbSNP
rs1434575733 578 dbSNP
rs1216399188 579 dbSNP
rs1259167151 579 dbSNP
rs1210905972 580 dbSNP
rs1288860920 583 dbSNP
rs1209374934 584 dbSNP
rs1039692610 593 dbSNP
rs1256700431 596 dbSNP
rs911839593 599 dbSNP
rs1324956150 600 dbSNP
rs1464807419 604 dbSNP
rs1206324021 611 dbSNP
rs945974982 616 dbSNP
rs1041545574 621 dbSNP
rs904358665 622 dbSNP
rs549726325 623 dbSNP
rs887204685 628 dbSNP
rs756689190 629 dbSNP
rs1053905005 630 dbSNP
rs1366286110 631 dbSNP
rs183516966 638 dbSNP
rs1473458240 641 dbSNP
rs1047005779 643 dbSNP
rs1192472046 646 dbSNP
rs905412071 661 dbSNP
rs1265803449 663 dbSNP
rs1387857870 663 dbSNP
rs554644175 664 dbSNP
rs545899269 665 dbSNP
rs1012272664 666 dbSNP
rs1287247078 666 dbSNP
rs1404435293 674 dbSNP
rs1025413473 677 dbSNP
rs1279926300 679 dbSNP
rs957015748 683 dbSNP
rs146922318 689 dbSNP
rs1257733320 694 dbSNP
rs569693712 695 dbSNP
rs1020001636 697 dbSNP
rs576105361 708 dbSNP
rs963553433 720 dbSNP
rs1329127729 721 dbSNP
rs973119512 729 dbSNP
rs1028728996 732 dbSNP
rs1397334185 735 dbSNP
rs1207376626 739 dbSNP
rs976679428 741 dbSNP
rs543410567 743 dbSNP
rs1465847843 744 dbSNP
rs74495539 745 dbSNP
rs963907513 746 dbSNP
rs575986884 749 dbSNP
rs919870946 751 dbSNP
rs540843703 757 dbSNP
rs755507536 758 dbSNP
rs1237643010 759 dbSNP
rs1047113741 769 dbSNP
rs977373536 770 dbSNP
rs1459276273 774 dbSNP
rs1483811448 778 dbSNP
rs1271482435 782 dbSNP
rs781585867 788 dbSNP
rs949510271 789 dbSNP
rs1246910615 791 dbSNP
rs1046512028 797 dbSNP
rs76338977 801 dbSNP
rs1178141778 802 dbSNP
rs1446860296 807 dbSNP
rs532998003 816 dbSNP
rs1402073365 819 dbSNP
rs1323475099 822 dbSNP
rs1405202742 824 dbSNP
rs1414997135 829 dbSNP
rs1002349230 832 dbSNP
rs535494903 835 dbSNP
rs1380172071 836 dbSNP
rs551456625 837 dbSNP
rs1179390645 838 dbSNP
rs1459118508 846 dbSNP
rs1251436720 849 dbSNP
rs1053849673 852 dbSNP
rs916646062 857 dbSNP
rs1452341920 859 dbSNP
rs73217770 863 dbSNP
rs1373913787 865 dbSNP
rs1351488209 867 dbSNP
rs1011171711 873 dbSNP
rs1309083028 874 dbSNP
rs1046358149 879 dbSNP
rs758401094 880 dbSNP
rs967119095 896 dbSNP
rs1008384675 902 dbSNP
rs1019398727 903 dbSNP
rs1005090182 904 dbSNP
rs115452244 907 dbSNP
rs975257688 908 dbSNP
rs1159774621 912 dbSNP
rs1441682674 922 dbSNP
rs1393359485 926 dbSNP
rs139372923 933 dbSNP
rs28384349 934 dbSNP
rs535304180 935 dbSNP
rs1487184030 937 dbSNP
rs1285294294 945 dbSNP
rs1029596567 950 dbSNP
rs1481956262 951 dbSNP
rs953130288 953 dbSNP
rs949455149 954 dbSNP
rs1367924986 955 dbSNP
rs1009073603 960 dbSNP
rs1018607761 968 dbSNP
rs967068655 970 dbSNP
rs938151414 976 dbSNP
rs977321361 977 dbSNP
rs1432494435 980 dbSNP
rs1357885489 984 dbSNP
rs1175516750 985 dbSNP
rs553424549 986 dbSNP
rs1427614209 991 dbSNP
rs1393330516 992 dbSNP
rs925881933 994 dbSNP
rs945639382 997 dbSNP
rs571859736 1010 dbSNP
rs1042679241 1013 dbSNP
rs1007922912 1014 dbSNP
rs1235642220 1019 dbSNP
rs957292026 1022 dbSNP
rs371459575 1025 dbSNP
rs1370127251 1034 dbSNP
rs539286454 1040 dbSNP
rs991292126 1041 dbSNP
rs915736671 1044 dbSNP
rs1019754030 1050 dbSNP
rs1279265359 1052 dbSNP
rs1295616685 1053 dbSNP
rs948123274 1060 dbSNP
rs557840762 1061 dbSNP
rs1046957414 1074 dbSNP
rs1448922652 1075 dbSNP
rs927980524 1078 dbSNP
rs940725204 1092 dbSNP
rs1465331960 1101 dbSNP
rs1036554688 1103 dbSNP
rs899402972 1104 dbSNP
rs1171186082 1109 dbSNP
rs1478662283 1114 dbSNP
rs576214969 1117 dbSNP
rs1273489225 1120 dbSNP
rs1339586268 1125 dbSNP
rs1181192584 1128 dbSNP
rs1223545691 1132 dbSNP
rs996645007 1134 dbSNP
rs1026828896 1136 dbSNP
rs995065631 1138 dbSNP
rs952559859 1143 dbSNP
rs1196163239 1144 dbSNP
rs1457082723 1148 dbSNP
rs1488148766 1151 dbSNP
rs1050584668 1152 dbSNP
rs1189396967 1153 dbSNP
rs371732893 1154 dbSNP
rs749537838 1156 dbSNP
rs1015537904 1160 dbSNP
rs771088747 1165 dbSNP
rs1381924812 1171 dbSNP
rs543018615 1177 dbSNP
rs1446099905 1178 dbSNP
rs1401351120 1182 dbSNP
rs143294306 1184 dbSNP
rs112110801 1188 dbSNP
rs982145747 1190 dbSNP
rs926684862 1191 dbSNP
rs1424357489 1192 dbSNP
rs938099029 1199 dbSNP
rs989573040 1205 dbSNP
rs1408399963 1206 dbSNP
rs915403639 1214 dbSNP
rs998496004 1222 dbSNP
rs150887242 1223 dbSNP
rs1222713907 1224 dbSNP
rs374749184 1226 dbSNP
rs368882723 1227 dbSNP
rs1377726209 1229 dbSNP
rs943677763 1240 dbSNP
rs1385309858 1241 dbSNP
rs541306226 1250 dbSNP
rs991816874 1252 dbSNP
rs1339945942 1255 dbSNP
rs372159087 1264 dbSNP
rs971672335 1268 dbSNP
rs186688993 1269 dbSNP
rs899547794 1271 dbSNP
rs982206226 1272 dbSNP
rs1380381443 1276 dbSNP
rs544810837 1285 dbSNP
rs1026773614 1291 dbSNP
rs1266205781 1292 dbSNP
rs775343183 1294 dbSNP
rs760453101 1300 dbSNP
rs1015899337 1301 dbSNP
rs1313243316 1302 dbSNP
rs563406030 1314 dbSNP
rs1003916335 1315 dbSNP
rs1330790121 1316 dbSNP
rs1302241659 1322 dbSNP
rs1387194014 1325 dbSNP
rs1320897591 1326 dbSNP
rs542656302 1327 dbSNP
rs373987932 1332 dbSNP
rs201238409 1333 dbSNP
rs959400710 1334 dbSNP
rs989521163 1336 dbSNP
rs1051158061 1341 dbSNP
rs1176313943 1344 dbSNP
rs375188348 1345 dbSNP
rs1209488734 1352 dbSNP
rs549237260 1353 dbSNP
rs944890419 1354 dbSNP
rs1474584717 1356 dbSNP
rs767580873 1357 dbSNP
rs117795225 1358 dbSNP
rs1256604255 1366 dbSNP
rs28718387 1383 dbSNP
rs1423615596 1385 dbSNP
rs1163171612 1386 dbSNP
rs528517492 1388 dbSNP
rs763953287 1393 dbSNP
rs879908103 1394 dbSNP
rs1276100946 1407 dbSNP
rs1458208362 1414 dbSNP
rs1341099956 1421 dbSNP
rs776088029 1427 dbSNP
rs1320200372 1438 dbSNP
rs1393847591 1440 dbSNP
rs1400884949 1443 dbSNP
rs1302846777 1448 dbSNP
rs1319368645 1455 dbSNP
rs1420959149 1456 dbSNP
rs1039335449 1457 dbSNP
rs920926944 1467 dbSNP
rs1375347642 1469 dbSNP
rs1186067773 1482 dbSNP
rs1442283627 1485 dbSNP
rs1256995562 1494 dbSNP
rs932326360 1496 dbSNP
rs1048156982 1497 dbSNP
rs1257631608 1504 dbSNP
rs1217851949 1510 dbSNP
rs547269596 1511 dbSNP
rs1303081576 1512 dbSNP
rs1339764702 1516 dbSNP
rs1312837237 1521 dbSNP
rs888218027 1526 dbSNP
rs1004432348 1527 dbSNP
rs1330254032 1530 dbSNP
rs149602283 1539 dbSNP
rs1289954299 1546 dbSNP
rs144290994 1549 dbSNP
rs1399087554 1550 dbSNP
rs906409877 1551 dbSNP
rs1472773298 1558 dbSNP
rs1227699315 1564 dbSNP
rs1283737585 1569 dbSNP
rs1437903650 1573 dbSNP
rs1237863173 1576 dbSNP
rs1199519384 1601 dbSNP
rs1439705680 1602 dbSNP
rs1274889329 1608 dbSNP
rs1207793991 1612 dbSNP
rs1355614640 1618 dbSNP
rs1247618139 1629 dbSNP
rs1374037257 1629 dbSNP
rs532538752 1629 dbSNP
rs57981128 1629 dbSNP
rs1307812091 1633 dbSNP
rs1445362532 1640 dbSNP
rs761474962 1641 dbSNP
rs1447104329 1646 dbSNP
rs1238297162 1655 dbSNP
rs1337112730 1661 dbSNP
rs1483028086 1664 dbSNP
rs1322046968 1665 dbSNP
rs764684471 1668 dbSNP
rs1186313000 1669 dbSNP
rs1414632625 1674 dbSNP
rs1379766717 1677 dbSNP
rs1473242973 1680 dbSNP
rs1003456044 1687 dbSNP
rs1245177668 1706 dbSNP
rs757580328 1709 dbSNP
rs1159077788 1717 dbSNP
rs1406352585 1720 dbSNP
rs1415707087 1722 dbSNP
rs1334202358 1726 dbSNP
rs1224636540 1731 dbSNP
rs1450813300 1731 dbSNP
rs879225661 1731 dbSNP
rs1033597709 1732 dbSNP
rs1284713614 1733 dbSNP
rs1223836111 1743 dbSNP
rs959348729 1743 dbSNP
rs1309688942 1744 dbSNP
rs781098578 1753 dbSNP
rs1346552520 1757 dbSNP
rs1305265375 1769 dbSNP
rs1398724841 1778 dbSNP
rs1010890312 1783 dbSNP
rs1350883411 1784 dbSNP
rs374110700 1785 dbSNP
rs745664296 1789 dbSNP
rs1423405323 1791 dbSNP
rs569742020 1794 dbSNP
rs111336661 1799 dbSNP
rs1269374287 1799 dbSNP
rs529086474 1799 dbSNP
rs1277722122 1800 dbSNP
rs78381444 1810 dbSNP
rs78442460 1811 dbSNP
rs966821618 1812 dbSNP
rs1262353045 1816 dbSNP
rs978630079 1820 dbSNP
rs769796213 1823 dbSNP
rs912055210 1826 dbSNP
rs1218281145 1831 dbSNP
rs1279395431 1852 dbSNP
rs1323748851 1857 dbSNP
rs966648673 1859 dbSNP
rs1285604296 1860 dbSNP
rs1347502345 1860 dbSNP
rs1217159050 1863 dbSNP
rs1340492908 1869 dbSNP
rs1289960518 1872 dbSNP
rs537130064 1878 dbSNP
rs1208990918 1879 dbSNP
rs28733446 1882 dbSNP
rs1254165372 1886 dbSNP
rs974971005 1896 dbSNP
rs1178378705 1897 dbSNP
rs140057976 1909 dbSNP
rs1422905466 1910 dbSNP
rs1231705317 1912 dbSNP
rs1479272834 1916 dbSNP
rs1235272329 1917 dbSNP
rs1208753405 1921 dbSNP
rs932278925 1922 dbSNP
rs1423845666 1923 dbSNP
rs749973120 1924 dbSNP
rs1432554067 1925 dbSNP
rs1317666638 1928 dbSNP
rs909586096 1929 dbSNP
rs1170103208 1930 dbSNP
rs749315275 1940 dbSNP
rs868323096 1941 dbSNP
rs573576284 1947 dbSNP
rs1453431814 1950 dbSNP
rs1428903475 1971 dbSNP
rs1329551207 1980 dbSNP
rs534323177 1981 dbSNP
rs1037223398 1992 dbSNP
rs906365127 2001 dbSNP
rs1170829383 2002 dbSNP
rs1003355891 2003 dbSNP
rs559471373 2025 dbSNP
rs1411500884 2028 dbSNP
rs28643366 2033 dbSNP
rs189925061 2034 dbSNP
rs1319991367 2038 dbSNP
rs1176408711 2039 dbSNP
rs1010822956 2042 dbSNP
rs1022260243 2052 dbSNP
rs1320483481 2069 dbSNP
rs143079361 2069 dbSNP
rs372363164 2069 dbSNP
rs1275584034 2073 dbSNP
rs773932520 2074 dbSNP
rs1370342768 2076 dbSNP
rs999612415 2089 dbSNP
rs1385106587 2090 dbSNP
rs544775101 2097 dbSNP
rs73417629 2098 dbSNP
rs182819813 2112 dbSNP
rs1298580743 2113 dbSNP
rs1319181298 2118 dbSNP
rs543097970 2119 dbSNP
rs561271741 2120 dbSNP
rs753256485 2122 dbSNP
rs1211569627 2125 dbSNP
rs1425157943 2125 dbSNP
rs374305163 2132 dbSNP
rs1240043990 2133 dbSNP
rs1477279911 2135 dbSNP
rs1176183200 2136 dbSNP
rs1418199808 2137 dbSNP
rs1250754274 2138 dbSNP
rs1179389200 2146 dbSNP
rs1487704442 2147 dbSNP
rs1453897272 2150 dbSNP
rs1029227775 2151 dbSNP
rs1347151399 2167 dbSNP
rs1223890934 2169 dbSNP
rs1362165734 2169 dbSNP
rs952278800 2173 dbSNP
rs756380008 2179 dbSNP
rs983756136 2180 dbSNP
rs528440325 2182 dbSNP
rs1452050720 2191 dbSNP
rs1317782995 2213 dbSNP
rs909543030 2226 dbSNP
rs1189888949 2233 dbSNP
rs778224682 2234 dbSNP
rs1428676876 2236 dbSNP
rs972492393 2237 dbSNP
rs1165998514 2245 dbSNP
rs1156347676 2259 dbSNP
rs1392610911 2260 dbSNP
rs927732972 2262 dbSNP
rs547026636 2263 dbSNP
rs939158656 2264 dbSNP
rs1054887409 2267 dbSNP
rs1322826439 2269 dbSNP
rs1431030307 2277 dbSNP
rs1429068045 2280 dbSNP
rs776919000 2281 dbSNP
rs749484569 2283 dbSNP
rs1299880755 2284 dbSNP
rs1366260380 2285 dbSNP
rs895032029 2297 dbSNP
rs565545947 2301 dbSNP
rs757595034 2302 dbSNP
rs1486226944 2304 dbSNP
rs539494753 2306 dbSNP
rs779115970 2317 dbSNP
rs1358916554 2323 dbSNP
rs1210754216 2328 dbSNP
rs1311785579 2329 dbSNP
rs1282452900 2341 dbSNP
rs1223864708 2343 dbSNP
rs1347393095 2353 dbSNP
rs946627300 2357 dbSNP
rs1044073126 2360 dbSNP
rs1467501079 2362 dbSNP
rs1210103934 2363 dbSNP
rs902492093 2367 dbSNP
rs999961014 2369 dbSNP
rs1190583250 2370 dbSNP
rs1428133247 2372 dbSNP
rs1177649128 2375 dbSNP
rs1018997822 2376 dbSNP
rs532879161 2379 dbSNP
rs901948664 2382 dbSNP
rs1415637366 2383 dbSNP
rs556511078 2387 dbSNP
rs1322712629 2388 dbSNP
rs1204128098 2391 dbSNP
rs1325445416 2392 dbSNP
rs1275999756 2394 dbSNP
rs1029175302 2397 dbSNP
rs1389468431 2397 dbSNP
rs1381656493 2398 dbSNP
rs1393754576 2399 dbSNP
rs1316517918 2402 dbSNP
rs952225378 2404 dbSNP
rs1470717658 2406 dbSNP
rs1055413887 2409 dbSNP
rs1246033406 2414 dbSNP
rs1293036316 2415 dbSNP
rs1333405056 2416 dbSNP
rs1230766403 2420 dbSNP
rs1269245909 2425 dbSNP
rs188300967 2426 dbSNP
rs1202802886 2427 dbSNP
rs1257874209 2428 dbSNP
rs1442612036 2430 dbSNP
rs759876907 2439 dbSNP
rs1194995085 2448 dbSNP
rs1032639012 2453 dbSNP
rs1415378056 2454 dbSNP
rs892845850 2455 dbSNP
rs961060019 2458 dbSNP
rs576468375 2459 dbSNP
rs1159825981 2466 dbSNP
rs192808949 2467 dbSNP
rs536489286 2476 dbSNP
rs556014682 2477 dbSNP
rs1161992654 2480 dbSNP
rs971236818 2486 dbSNP
rs1424513543 2488 dbSNP
rs1385976729 2490 dbSNP
rs981658690 2491 dbSNP
rs1438122714 2492 dbSNP
rs990563174 2498 dbSNP
rs1015396873 2507 dbSNP
rs1438168747 2508 dbSNP
rs1396810492 2519 dbSNP
rs962071060 2521 dbSNP
rs1252331767 2525 dbSNP
rs972127825 2529 dbSNP
rs1358592351 2530 dbSNP
rs1291899637 2539 dbSNP
rs1247505045 2545 dbSNP
rs758996441 2551 dbSNP
rs548268115 2552 dbSNP
rs1278576194 2555 dbSNP
rs1043634456 2559 dbSNP
rs930664969 2560 dbSNP
rs772042823 2563 dbSNP
rs28597772 2567 dbSNP
rs901896272 2570 dbSNP
rs117459500 2571 dbSNP
rs944988897 2572 dbSNP
rs572640717 2576 dbSNP
rs1407599260 2579 dbSNP
rs567256628 2582 dbSNP
rs775224722 2585 dbSNP
rs934393813 2589 dbSNP
rs1196955733 2596 dbSNP
rs1490179995 2597 dbSNP
rs1257221722 2602 dbSNP
rs1054239418 2613 dbSNP
rs1209703474 2614 dbSNP
rs746978875 2621 dbSNP
rs1013022613 2622 dbSNP
rs1399615726 2628 dbSNP
rs1224027148 2629 dbSNP
rs1483922856 2633 dbSNP
rs1182577140 2639 dbSNP
rs185268832 2645 dbSNP
rs552569026 2663 dbSNP
rs764033974 2664 dbSNP
rs114802215 2667 dbSNP
rs374994940 2670 dbSNP
rs962627975 2672 dbSNP
rs1429162406 2674 dbSNP
rs530672833 2678 dbSNP
rs1379438517 2686 dbSNP
rs993814658 2691 dbSNP
rs1319017952 2692 dbSNP
rs73417631 2693 dbSNP
rs960399150 2702 dbSNP
rs1174043868 2703 dbSNP
rs990511193 2704 dbSNP
rs1429662264 2710 dbSNP
rs1432050684 2711 dbSNP
rs916357746 2715 dbSNP
rs1373311704 2717 dbSNP
rs1241043669 2725 dbSNP
rs541620628 2729 dbSNP
rs967824118 2731 dbSNP
rs1448415186 2732 dbSNP
rs1015344528 2736 dbSNP
rs979691867 2739 dbSNP
rs923844029 2740 dbSNP
rs1213356187 2744 dbSNP
rs935255200 2749 dbSNP
rs961235748 2750 dbSNP
rs376448883 2757 dbSNP
rs548843572 2759 dbSNP
rs755282252 2759 dbSNP
rs1277780241 2760 dbSNP
rs1343811531 2762 dbSNP
rs1205665291 2773 dbSNP
rs1250533688 2774 dbSNP
rs1479654456 2775 dbSNP
rs1192853160 2777 dbSNP
rs1267901227 2779 dbSNP
rs1454779095 2782 dbSNP
rs1193042797 2783 dbSNP
rs575393491 2793 dbSNP
rs1186671383 2803 dbSNP
rs1476099024 2822 dbSNP
rs923266747 2823 dbSNP
rs371329365 2825 dbSNP
rs1050489027 2828 dbSNP
rs1171631380 2828 dbSNP
rs1461456617 2832 dbSNP
rs1354311652 2836 dbSNP
rs542460388 2839 dbSNP
rs887874926 2845 dbSNP
rs1274317449 2852 dbSNP
rs1216777117 2874 dbSNP
rs1357376748 2877 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000538010.1 | 3UTR | UAAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000538010.1 | 3UTR | AUAAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000538010.1 | 3UTR | UAAGGGAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000538010.1 | 3UTR | AAGGGAAAAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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