pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ABCC12   
Synonyms MRP9
Description ATP binding cassette subfamily C member 12
Transcript NM_033226   
Expression
Putative miRNA Targets on ABCC12
3'UTR of ABCC12
(miRNA target sites are highlighted)
>ABCC12|NM_033226|3'UTR
   1 AGGTCCTGGCGGCTGATTCTAGAGGAGGAAGAGGCTCTGTGAGATGAATAGGAGGAGTCTTCAGGAGGAGGGGCTGTCCT
  81 CTCCGCAGGCAGCCCTGGTCTTCAGCCCCTCCCATCCACGGAGTGAGCTGGGGCTGAAGTTGTCCCCACTGCCATACTCA
 161 GTCCATGTCACCCCACTTGGTGGGCTTGGGGTTGGTTCTGGGTGGTGAACCGGGGCAGACCCAGCTAATGGATTAAAAAA
 241 CTGCCCTTCACCTCCCAAATCCCCAAGGGTTCCTCATGTGTTTTCACCAAAACCACCCCAGTGCCTGAGATTGAAAATAT
 321 TGTAACTTTCAGTTAGAAATCAGCCACAATAAACAACATGGGAAAATGCCTTAGGATGGAGTTTGCAAGGTTTCCTTGCC
 401 CATTATCAGAAGGAAAAAGAGCAGAATTTTCTTCTCGTTTAACCCCACTCACTTCCATCTTGACTGGGTGACAAGTGGTA
 481 ATGACACAGATTTGTAGCGTGAAAGACTGAATACAGTGTTTGGCCAAAAATTTTTTTAAAAATCATATTATATGTTTCAA
 561 TTGATCTGTTAGAATAACCAAGAAAACAAAATGCTGGAGTTTCTCTATAAATGACACTTTTATATCTTCTTTATTCGTCG
 641 TTAAAACGCGGTAGGAAATTACCCTGAAATGTCGCCTTGCAATTATTTCACTGAAGATATTCCAATTTCCATACTATTTC
 721 CTCCAATAGACCCTTGTTGCCT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauacccacCCUGUCUCUCCc 5'
                   ||| :|||:|| 
Target 5' gagtcttcaGGA-GGAGGGGc 3'
55 - 74 115.00 -12.80
2
miRNA  3' gauacCCACC--CU---GUCU-CUCCc 5'
               || ||  ||   :||| |||| 
Target 5' gtcctGGCGGCTGATTCTAGAGGAGGa 3'
3 - 29 114.00 -13.00
3
miRNA  3' gaUACCCACCCUGUCUCUCcc 5'
            ||  |  ||| | ||||  
Target 5' ttATCAGAAGGAAAAAGAGca 3'
403 - 423 103.00 -6.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30191124 10 COSMIC
COSN30506371 11 COSMIC
COSN30561944 21 COSMIC
COSN8601691 28 COSMIC
COSN30479160 74 COSMIC
COSN13673562 85 COSMIC
COSN6413979 98 COSMIC
COSN30461719 106 COSMIC
COSN30460857 107 COSMIC
COSN26964422 109 COSMIC
COSN30535426 120 COSMIC
COSN30178656 121 COSMIC
COSN31525705 147 COSMIC
COSN20078625 165 COSMIC
COSN30110076 215 COSMIC
COSN31505014 245 COSMIC
COSN7258234 530 COSMIC
COSN7258233 538 COSMIC
COSN21441578 543 COSMIC
COSN17181901 640 COSMIC
COSN31959678 647 COSMIC
COSN25361741 674 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1433138342 1 dbSNP
rs1338969082 2 dbSNP
rs11864455 3 dbSNP
rs1402203713 10 dbSNP
rs371058499 11 dbSNP
rs772559184 17 dbSNP
rs748418889 20 dbSNP
rs183749700 31 dbSNP
rs202012111 38 dbSNP
rs1366823962 43 dbSNP
rs768722658 45 dbSNP
rs1408910925 46 dbSNP
rs374219486 49 dbSNP
rs894660769 57 dbSNP
rs1277696425 58 dbSNP
rs1444228282 58 dbSNP
rs1476312014 59 dbSNP
rs985997407 61 dbSNP
rs1056418899 67 dbSNP
rs1345238150 69 dbSNP
rs1209734205 72 dbSNP
rs1278286700 78 dbSNP
rs920347413 84 dbSNP
rs936271975 85 dbSNP
rs1470120464 95 dbSNP
rs924912318 111 dbSNP
rs1206527219 116 dbSNP
rs979108497 119 dbSNP
rs759632420 120 dbSNP
rs1015824167 131 dbSNP
rs34076060 137 dbSNP
rs1326661582 139 dbSNP
rs971702933 144 dbSNP
rs1023080786 154 dbSNP
rs1353823850 158 dbSNP
rs751710928 163 dbSNP
rs1327268829 172 dbSNP
rs1357011466 174 dbSNP
rs1291009232 176 dbSNP
rs1233022413 194 dbSNP
rs766672330 195 dbSNP
rs1396555678 200 dbSNP
rs531902143 202 dbSNP
rs763241284 204 dbSNP
rs1214888544 205 dbSNP
rs903200296 209 dbSNP
rs61080373 210 dbSNP
rs41280919 211 dbSNP
rs76139125 212 dbSNP
rs1476535859 214 dbSNP
rs769621635 218 dbSNP
rs1050216847 220 dbSNP
rs1327842263 221 dbSNP
rs1187452055 226 dbSNP
rs375883229 231 dbSNP
rs1392280378 240 dbSNP
rs930472727 243 dbSNP
rs1318468676 244 dbSNP
rs1327802090 247 dbSNP
rs1472996677 252 dbSNP
rs761515229 261 dbSNP
rs1024369749 263 dbSNP
rs1234367972 270 dbSNP
rs1175493323 276 dbSNP
rs372772067 277 dbSNP
rs920314498 282 dbSNP
rs1250654930 287 dbSNP
rs1262553425 294 dbSNP
rs1448907630 297 dbSNP
rs1214123095 298 dbSNP
rs1191316569 304 dbSNP
rs1262114269 311 dbSNP
rs1475408856 321 dbSNP
rs1166908251 324 dbSNP
rs1457385335 329 dbSNP
rs1336651234 330 dbSNP
rs1270928941 334 dbSNP
rs894599277 344 dbSNP
rs1386524239 351 dbSNP
rs1398535068 354 dbSNP
rs1232299197 355 dbSNP
rs879049587 357 dbSNP
rs1055967878 369 dbSNP
rs1415755042 370 dbSNP
rs1000855570 375 dbSNP
rs1354068045 376 dbSNP
rs940475997 379 dbSNP
rs927607298 382 dbSNP
rs1352935085 387 dbSNP
rs1203534703 394 dbSNP
rs1285560295 399 dbSNP
rs1486151199 401 dbSNP
rs1335894302 407 dbSNP
rs531892174 412 dbSNP
rs1189767232 416 dbSNP
rs981833354 422 dbSNP
rs1255181669 426 dbSNP
rs1423128693 433 dbSNP
rs879629053 436 dbSNP
rs776571832 437 dbSNP
rs76912927 446 dbSNP
rs375095231 450 dbSNP
rs768496044 451 dbSNP
rs1392728756 452 dbSNP
rs1315118016 459 dbSNP
rs552604483 471 dbSNP
rs746479849 472 dbSNP
rs1395884855 478 dbSNP
rs1454512473 494 dbSNP
rs1338105133 496 dbSNP
rs933764009 498 dbSNP
rs921094092 499 dbSNP
rs1348822879 509 dbSNP
rs372560017 511 dbSNP
rs1277858388 521 dbSNP
rs962605381 523 dbSNP
rs191099565 530 dbSNP
rs1252565214 531 dbSNP
rs982712424 531 dbSNP
rs78719042 537 dbSNP
rs1177421483 538 dbSNP
rs1469704976 539 dbSNP
rs567533143 545 dbSNP
rs1359788746 554 dbSNP
rs1024317231 560 dbSNP
rs1171368452 593 dbSNP
rs1376780633 595 dbSNP
rs898980136 597 dbSNP
rs1299143839 599 dbSNP
rs41280917 602 dbSNP
rs1262072339 605 dbSNP
rs1236312395 610 dbSNP
rs1445260100 616 dbSNP
rs1330705088 617 dbSNP
rs940429127 624 dbSNP
rs927773380 626 dbSNP
rs1311894002 636 dbSNP
rs560808940 637 dbSNP
rs778495712 639 dbSNP
rs756435085 640 dbSNP
rs1443732296 647 dbSNP
rs544104290 647 dbSNP
rs753018847 648 dbSNP
rs181292375 649 dbSNP
rs114144417 650 dbSNP
rs1428791423 651 dbSNP
rs957641048 661 dbSNP
rs926108658 671 dbSNP
rs868252220 673 dbSNP
rs1010458413 674 dbSNP
rs1387449811 678 dbSNP
rs142350875 685 dbSNP
rs1443184820 695 dbSNP
rs1291912775 698 dbSNP
rs967828344 704 dbSNP
rs545074207 713 dbSNP
rs1019039794 716 dbSNP
rs1297376840 725 dbSNP
rs1050787168 726 dbSNP
rs933727069 733 dbSNP
rs141343813 734 dbSNP
rs1039923431 737 dbSNP
rs1978351 752 dbSNP
rs1245658605 764 dbSNP
rs779407710 771 dbSNP
rs1455544446 775 dbSNP
rs1264219957 776 dbSNP
rs909728234 784 dbSNP
rs1393123764 786 dbSNP
rs1193473871 787 dbSNP
rs372097948 788 dbSNP
rs1463514144 793 dbSNP
rs929878699 799 dbSNP
rs917234712 801 dbSNP
rs1162707415 808 dbSNP
rs1349381080 831 dbSNP
rs992879274 837 dbSNP
rs1036600881 842 dbSNP
rs1338791880 851 dbSNP
rs1399141690 854 dbSNP
rs76186659 861 dbSNP
rs1357241873 862 dbSNP
rs74441655 863 dbSNP
rs1046159112 865 dbSNP
rs979275946 868 dbSNP
rs555271375 874 dbSNP
rs947699161 884 dbSNP
rs1217401416 892 dbSNP
rs1258573373 899 dbSNP
rs894793224 899 dbSNP
rs1216308104 900 dbSNP
rs968829202 901 dbSNP
rs1258678350 906 dbSNP
rs1346385599 907 dbSNP
rs1180625710 917 dbSNP
rs1303257109 928 dbSNP
rs936247697 937 dbSNP
rs1176962373 945 dbSNP
rs1161435920 946 dbSNP
rs1020419099 948 dbSNP
rs977959728 949 dbSNP
rs1010405917 953 dbSNP
rs1377063101 955 dbSNP
rs946251800 956 dbSNP
rs1283523919 971 dbSNP
rs890741428 981 dbSNP
rs1224949109 985 dbSNP
rs1306509475 986 dbSNP
rs1029727679 988 dbSNP
rs1352479746 989 dbSNP
rs997885180 993 dbSNP
rs899515281 994 dbSNP
rs190233309 999 dbSNP
rs953470453 1019 dbSNP
rs1444481550 1020 dbSNP
rs941095078 1024 dbSNP
rs1432890360 1040 dbSNP
rs888241157 1044 dbSNP
rs1046969514 1050 dbSNP
rs370135234 1055 dbSNP
rs917203521 1061 dbSNP
rs1378569092 1062 dbSNP
rs1439256494 1063 dbSNP
rs1174500418 1069 dbSNP
rs1171896414 1078 dbSNP
rs1397194871 1080 dbSNP
rs993222023 1081 dbSNP
rs937337482 1082 dbSNP
rs927299971 1084 dbSNP
rs1412536578 1085 dbSNP
rs1333326445 1090 dbSNP
rs1355008947 1091 dbSNP
rs569416401 1092 dbSNP
rs978781624 1095 dbSNP
rs1374565960 1099 dbSNP
rs1190681623 1101 dbSNP
rs1328614620 1102 dbSNP
rs1477292263 1106 dbSNP
rs1375521679 1111 dbSNP
rs1234464004 1112 dbSNP
rs1305152740 1114 dbSNP
rs1257726834 1118 dbSNP
rs1014849467 1119 dbSNP
rs968778140 1126 dbSNP
rs367862420 1136 dbSNP
rs1005094582 1137 dbSNP
rs552523184 1138 dbSNP
rs1020407651 1139 dbSNP
rs988967179 1150 dbSNP
rs1457367244 1153 dbSNP
rs955110195 1166 dbSNP
rs1194413211 1167 dbSNP
rs1030559290 1171 dbSNP
rs906383178 1172 dbSNP
rs1419995766 1177 dbSNP
rs1025249080 1179 dbSNP
rs1011936659 1186 dbSNP
rs996844354 1190 dbSNP
rs549222430 1193 dbSNP
rs186255962 1201 dbSNP
rs1212433527 1208 dbSNP
rs763185339 1216 dbSNP
rs28560105 1217 dbSNP
rs936350624 1219 dbSNP
rs1340507948 1227 dbSNP
rs904746880 1229 dbSNP
rs1005302017 1232 dbSNP
rs888229954 1236 dbSNP
rs1046920111 1239 dbSNP
rs866035968 1241 dbSNP
rs929819885 1242 dbSNP
rs546698798 1243 dbSNP
rs895660357 1245 dbSNP
rs750656104 1248 dbSNP
rs1450037986 1256 dbSNP
rs987674327 1264 dbSNP
rs1057021334 1267 dbSNP
rs1478670521 1281 dbSNP
rs377416480 1289 dbSNP
rs922012569 1294 dbSNP
rs765387735 1296 dbSNP
rs973367137 1303 dbSNP
rs1461921283 1309 dbSNP
rs181736425 1310 dbSNP
rs963385694 1311 dbSNP
rs761617100 1322 dbSNP
rs1043079325 1325 dbSNP
rs1333493197 1330 dbSNP
rs560968261 1334 dbSNP
rs750092840 1350 dbSNP
rs550427699 1352 dbSNP
rs947460893 1353 dbSNP
rs913341630 1354 dbSNP
rs1340413791 1359 dbSNP
rs1234468258 1374 dbSNP
rs988874417 1375 dbSNP
rs1354327327 1389 dbSNP
rs1418188078 1392 dbSNP
rs1209375361 1395 dbSNP
rs1189592994 1396 dbSNP
rs776317384 1404 dbSNP
rs868738199 1407 dbSNP
rs894865227 1408 dbSNP
rs1032066876 1409 dbSNP
rs1181829988 1412 dbSNP
rs1000466104 1419 dbSNP
rs1158694020 1422 dbSNP
rs1362035941 1426 dbSNP
rs902161495 1436 dbSNP
rs1296688596 1438 dbSNP
rs1360305816 1446 dbSNP
rs530748195 1447 dbSNP
rs1315418554 1457 dbSNP
rs763913627 1465 dbSNP
rs1244113566 1466 dbSNP
rs1280240807 1471 dbSNP
rs565070967 1474 dbSNP
rs1356061204 1475 dbSNP
rs1010480414 1477 dbSNP
rs1284959451 1479 dbSNP
rs544923680 1480 dbSNP
rs1485874684 1490 dbSNP
rs189875737 1497 dbSNP
rs1202028229 1510 dbSNP
rs1441811834 1513 dbSNP
rs761566790 1515 dbSNP
rs760582286 1516 dbSNP
rs1017943493 1527 dbSNP
rs1005252843 1529 dbSNP
rs1381653428 1531 dbSNP
rs890742780 1541 dbSNP
rs775463547 1542 dbSNP
rs1025378136 1547 dbSNP
rs377332366 1550 dbSNP
rs1395363329 1554 dbSNP
rs1051895677 1563 dbSNP
rs751354587 1567 dbSNP
rs994337936 1568 dbSNP
rs1395980151 1570 dbSNP
rs932144625 1573 dbSNP
rs1379214874 1575 dbSNP
rs1444738765 1587 dbSNP
rs895616079 1590 dbSNP
rs921981396 1592 dbSNP
rs1057367609 1601 dbSNP
rs185743951 1603 dbSNP
rs905809965 1606 dbSNP
rs1043019998 1637 dbSNP
rs1254060743 1641 dbSNP
rs1231672131 1646 dbSNP
rs907855184 1647 dbSNP
rs542763610 1652 dbSNP
rs983889754 1657 dbSNP
rs1280209154 1664 dbSNP
rs573642017 1667 dbSNP
rs1253203379 1671 dbSNP
rs917842611 1679 dbSNP
rs1178625772 1683 dbSNP
rs913248423 1685 dbSNP
rs1445830715 1686 dbSNP
rs990586271 1688 dbSNP
rs1172005392 1694 dbSNP
rs1053098982 1698 dbSNP
rs933401801 1706 dbSNP
rs1330815346 1714 dbSNP
rs923459321 1717 dbSNP
rs1032162188 1718 dbSNP
rs1459560697 1728 dbSNP
rs144480809 1734 dbSNP
rs964975522 1752 dbSNP
rs1298849230 1753 dbSNP
rs909489401 1756 dbSNP
rs966897535 1758 dbSNP
rs985060706 1761 dbSNP
rs1020616689 1774 dbSNP
rs1259882814 1782 dbSNP
rs1316027415 1805 dbSNP
rs952331185 1809 dbSNP
rs1025325226 1815 dbSNP
rs1469235773 1819 dbSNP
rs1052029197 1822 dbSNP
rs993893374 1824 dbSNP
rs1266316153 1829 dbSNP
rs996322272 1829 dbSNP
rs374903896 1830 dbSNP
rs139741989 1836 dbSNP
rs1426371569 1837 dbSNP
rs575894010 1839 dbSNP
rs1464549830 1841 dbSNP
rs1212133715 1845 dbSNP
rs773909257 1849 dbSNP
rs1037900100 1851 dbSNP
rs1285155613 1869 dbSNP
rs1035522458 1879 dbSNP
rs1225587344 1880 dbSNP
rs1459582731 1886 dbSNP
rs745385448 1893 dbSNP
rs907990070 1895 dbSNP
rs1348593458 1901 dbSNP
rs1400344267 1903 dbSNP
rs181942798 1904 dbSNP
rs1001796883 1913 dbSNP
rs905722000 1918 dbSNP
rs1445941836 1929 dbSNP
rs538815737 1938 dbSNP
rs917811485 1941 dbSNP
rs773998933 1966 dbSNP
rs990681188 1973 dbSNP
rs1322993565 1975 dbSNP
rs1218814933 1979 dbSNP
rs1264472428 1983 dbSNP
rs144847930 1985 dbSNP
rs546662005 1990 dbSNP
rs1265826115 2003 dbSNP
rs925110112 2005 dbSNP
rs1193583182 2011 dbSNP
rs542194065 2014 dbSNP
rs536362903 2017 dbSNP
rs1162813970 2018 dbSNP
rs1368069882 2019 dbSNP
rs1420560431 2025 dbSNP
rs188158088 2027 dbSNP
rs375098736 2031 dbSNP
rs1348966378 2036 dbSNP
rs891756278 2037 dbSNP
rs1053085938 2041 dbSNP
rs111768275 2045 dbSNP
rs530833361 2055 dbSNP
rs1226088135 2060 dbSNP
rs1311428393 2065 dbSNP
rs1353916018 2072 dbSNP
rs1241892642 2077 dbSNP
rs1288520214 2080 dbSNP
rs1039186721 2082 dbSNP
rs1157467747 2089 dbSNP
rs565075965 2099 dbSNP
rs909395978 2104 dbSNP
rs1238522004 2105 dbSNP
rs551666015 2106 dbSNP
rs528230179 2113 dbSNP
rs1180137539 2114 dbSNP
rs955233304 2117 dbSNP
rs376577379 2124 dbSNP
rs929548108 2129 dbSNP
rs918254415 2132 dbSNP
rs59721874 2136 dbSNP
rs900787301 2137 dbSNP
rs1176575564 2141 dbSNP
rs959805253 2142 dbSNP
rs183606462 2161 dbSNP
rs1360786062 2164 dbSNP
rs1445766710 2172 dbSNP
rs979888323 2177 dbSNP
rs1377004962 2178 dbSNP
rs1448440201 2178 dbSNP
rs1306618368 2185 dbSNP
rs1352595160 2190 dbSNP
rs1223534673 2204 dbSNP
rs115596218 2206 dbSNP
rs1021415556 2212 dbSNP
rs563268524 2217 dbSNP
rs1243137136 2222 dbSNP
rs543482819 2223 dbSNP
rs191837867 2226 dbSNP
rs558937116 2230 dbSNP
rs1031656784 2234 dbSNP
rs997948019 2243 dbSNP
rs901863724 2244 dbSNP
rs1439352253 2245 dbSNP
rs1218210761 2248 dbSNP
rs1039502513 2257 dbSNP
rs943443986 2278 dbSNP
rs75379854 2281 dbSNP
rs1401019203 2283 dbSNP
rs1285421239 2298 dbSNP
rs1049297464 2300 dbSNP
rs949522825 2313 dbSNP
rs1328720843 2314 dbSNP
rs1375630279 2317 dbSNP
rs1436763055 2325 dbSNP
rs896479871 2331 dbSNP
rs1217891640 2332 dbSNP
rs1348541347 2333 dbSNP
rs573322969 2336 dbSNP
rs1263037715 2337 dbSNP
rs1305474427 2337 dbSNP
rs553186492 2347 dbSNP
rs1256263322 2349 dbSNP
rs747507349 2352 dbSNP
rs116045459 2355 dbSNP
rs1366638448 2358 dbSNP
rs72802141 2359 dbSNP
rs556929622 2361 dbSNP
rs1432474913 2364 dbSNP
rs1190460003 2378 dbSNP
rs1424217370 2380 dbSNP
rs1343004233 2383 dbSNP
rs1297073205 2385 dbSNP
rs1167841598 2388 dbSNP
rs78634100 2389 dbSNP
rs945215340 2395 dbSNP
rs913627433 2398 dbSNP
rs542381853 2408 dbSNP
rs928328561 2411 dbSNP
rs1434724698 2422 dbSNP
rs571621889 2423 dbSNP
rs1433039318 2444 dbSNP
rs1341627938 2448 dbSNP
rs1221019193 2449 dbSNP
rs1276313697 2452 dbSNP
rs1338822912 2455 dbSNP
rs139463800 2460 dbSNP
rs975113252 2466 dbSNP
rs1188599561 2473 dbSNP
rs964917903 2474 dbSNP
rs1221415344 2490 dbSNP
rs764016932 2493 dbSNP
rs1474552715 2516 dbSNP
rs1262695426 2522 dbSNP
rs1021403990 2525 dbSNP
rs1489190645 2535 dbSNP
rs1191409721 2542 dbSNP
rs528419233 2545 dbSNP
rs1372490425 2556 dbSNP
rs1472827202 2557 dbSNP
rs1164534660 2559 dbSNP
rs1211714476 2561 dbSNP
rs1016935062 2562 dbSNP
rs1486682710 2571 dbSNP
rs1404420560 2574 dbSNP
rs879591474 2580 dbSNP
rs1282469118 2586 dbSNP
rs565854486 2588 dbSNP
rs1302864587 2594 dbSNP
rs1006367197 2596 dbSNP
rs886590567 2599 dbSNP
rs1207916197 2601 dbSNP
rs989968717 2605 dbSNP
rs1326410606 2608 dbSNP
rs1245578111 2609 dbSNP
rs1286064614 2610 dbSNP
rs1354433228 2622 dbSNP
rs1026514061 2624 dbSNP
rs8046592 2625 dbSNP
rs896615036 2630 dbSNP
rs1296031992 2636 dbSNP
rs1055010556 2643 dbSNP
rs1216062953 2650 dbSNP
rs1337989955 2651 dbSNP
rs1031984812 2658 dbSNP
rs1158872390 2661 dbSNP
rs1381845669 2663 dbSNP
rs1157236082 2669 dbSNP
rs1414909050 2669 dbSNP
rs1356813574 2681 dbSNP
rs1384824986 2690 dbSNP
rs938022338 2694 dbSNP
rs1336172117 2703 dbSNP
rs762771731 2706 dbSNP
rs1452078368 2711 dbSNP
rs1356169416 2715 dbSNP
rs903753276 2716 dbSNP
rs1311657983 2719 dbSNP
rs1044052357 2721 dbSNP
rs901808826 2722 dbSNP
rs532900023 2729 dbSNP
rs528987544 2730 dbSNP
rs60250034 2738 dbSNP
rs1178769518 2740 dbSNP
rs1007646396 2741 dbSNP
rs1239588270 2753 dbSNP
rs1437472928 2757 dbSNP
rs887896176 2758 dbSNP
rs986685513 2773 dbSNP
rs1188886551 2774 dbSNP
rs114776028 2776 dbSNP
rs1255506841 2779 dbSNP
rs150535687 2786 dbSNP
rs1379345923 2791 dbSNP
rs757386377 2792 dbSNP
rs1331458599 2794 dbSNP
rs1057083172 2801 dbSNP
rs1235226732 2803 dbSNP
rs939620827 2804 dbSNP
rs928286558 2812 dbSNP
rs1251765070 2817 dbSNP
rs1198667672 2818 dbSNP
rs1044100396 2819 dbSNP
rs1206419581 2820 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000416054.1 | 3UTR | gggcgcuaugcaaaacuga
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000416054.1 | 3UTR | agagagaggaagaugc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000416054.1 | 3UTR | gagagagaggaagaugc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000416054.1 | 3UTR | gagagagaggaagaugc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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