pre-miRNA Information
pre-miRNA hsa-mir-637   
Genomic Coordinates chr19: 3961414 - 3961512
Synonyms MIRN637, hsa-mir-637, MIR637
Description Homo sapiens miR-637 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-637
Sequence 61| ACUGGGGGCUUUCGGGCUCUGCGU |84
Evidence Experimental
Experiments SAGE
Expression Profile
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN518997 2 COSMIC
COSN1082357 6 COSMIC
COSN13804010 13 COSMIC
COSN1082358 14 COSMIC
COSN30450169 14 COSMIC
COSN30532059 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1416171403 2 dbSNP
rs200224173 4 dbSNP
rs1475121792 9 dbSNP
rs202144891 13 dbSNP
rs767027646 14 dbSNP
rs529226642 16 dbSNP
rs751534327 17 dbSNP
rs758718359 17 dbSNP
rs149472696 20 dbSNP
rs773105166 21 dbSNP
rs543903246 22 dbSNP
rs374248027 24 dbSNP
Putative Targets

Gene Information
Gene Symbol CCNF   
Synonyms FBX1, FBXO1
Description cyclin F
Transcript NM_001761   
Expression
Putative miRNA Targets on CCNF
3'UTR of CCNF
(miRNA target sites are highlighted)
>CCNF|NM_001761|3'UTR
   1 GTGTGTCAGCACATTTGCCGCAGTGGATGTGTACTGAGGGGGCTGGAGGCGAAGGGTGGGAGCATAGCATAGGAACGCTG
  81 CATAGACCATGGAGGCCTTTGCGCAGAGAGCAGAGAGGATGACTTGCGGCCACCAAGTTTCTGTCTCCGCGGGAGTCCCG
 161 TGCAAGCCATCAGAATGTTGAAATGAGGGTGAAGAGCTCAGATCCCTCTCTTTGGAAAGTTTAGCCTGGAAGCAGTTGGC
 241 CACACTGTGTGGAGGGCACCTCTCTGTCCCTTCCGTGTCTCACTGTCTCTGGAAGCTTCAGCCCATGTGTGTCCTGGTGT
 321 TCCCAGCCCCACCAGAGCCCCGTGCCGGGAGCTGACAGCTTTCACGCTTAAGGCACGTGTGACCTGGGTAGTCAGACACC
 401 ACTTGAGCCCCTGCCCACATCTGCTGGTTTGGGGCTTCAGTGGGGAGCTGACAGCTGTGAGCACACCACTGTCCCCTCAT
 481 CCACCTCGGCCTGCATGGGGCACCCACTTCCTTCTGGGTGGGGCTTCCATGGTAAGGGGGCCTGCGTCCCTGCACACTGC
 561 GAGGACTGCCTTGGCCACAGGCCCACTCCCTACGACACGTGACTCGTTTTAGAGCTCTGTCCCAGAGGCGTTCGTATGTG
 641 ACCCACAGATGGCGTCAATGTGAACACCTCTCTTTGTGCTGAATTTCTGGGCCATTCTTTTCCTGTCTTATTTCTAAATT
 721 TCCTTCTTCCAAGATGAAAACAAAAGAAAAACTTAAAACAGAAGGTATTAAAAAAACAAGAGATTCCCACCATTATTTAG
 801 GTTCACCTGCAAAACAAAAATCTTACTCCAGCCCCTCAATGCCATCCTGACACACTTTATGCAAAAAGAATTTTCCCAGA
 881 TAGGCTAGCCAGAAAAAACTTCAAGTCCTCTGTAACATCTGAGGTGACCAAGAGGCAGAAGAGCAGAGCAGTCGGGGGCC
 961 GTGTCCTGGCTGATCCCAACTGCAGCTCTGCTGTGGGGGCCCGTGGGAGGGAGGCAGACCCCTGGGCTTTCCTGCTGGCC
1041 ACGGAGACTCTGCTCCTGCATGGAAAGGGAGCCTGGGAGCCAGCAGCCCACGCCTGGGGAGCCTGCCTGGGGCCATGTGA
1121 CCATGGCCTCTCCCTGGGAACGGGCTGACCACAACACACCCTGCTGCCATCCACTTCTGTTTACTCTGCAAATGTAAGAA
1201 AGAACCACTTGGCCAGAAGTGTCCCCCAGATGCTTTTTTTTTTTTTTTTTTGGAGACAGTTTTGCTCTTGTCTCCCCGGC
1281 TGGAGTGCAGTGGCATGATCTCAACTCTCAACTCACTGTAACCTCCGCCTCCCGGATACTCCTGCCTCAGCCTCCTGGGT
1361 AGCTGGGATTACAAGCACCCAACCACGCCCAGCTAATTTTTGTATTTTCGGTAGAGACGGGATTTCACCATGTTGGCCAG
1441 GCTAGTCTCGAACTCATGACCTCAAGTGATCCGCCCACTTCGGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACGG
1521 CGCCTGGCCCCCAAATGCTCTTGAACCGGAAACCCAGGGATGGGAGATGCTCACTGAGCTGCTGCTTTTATGTGTGCTGG
1601 TGCTATGTGTGTTCATGTCCGCGGCAGCTGTCTTTTTGCTACTATAAGGGAATTCTGGCCACCCTGGGTGGGGTGTGGTC
1681 GGGGTGAGAACCCAAGCGTTGGAACTGTAGACCCGTCCTGTCGACTGTGTGCCCCTGGGCATGTGTGAGCCTCAGTTTCC
1761 TCATCTGTAAGGGGGGCAATGATACCTACCTCACAGGGGTGTTGTGAGGATTAAATGTGAGGAGGATAGTGGCAGATG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugcgucUCGGGCUUU-C-GGGGGUCa 5'
                :||| |||: | ||||||| 
Target 5' ccacttGGCCAGAAGTGTCCCCCAGa 3'
1205 - 1230 158.00 -21.80
2
miRNA  3' ugCGU-CUCGG-GCU----UUCGGGGGUca 5'
            ||| ||||| ||:     :|||||||  
Target 5' agGCATGAGCCACGGCGCCTGGCCCCCAaa 3'
1506 - 1535 144.00 -28.10
3
miRNA  3' ugcguCUCGGGCUUUCGGGGGUCa 5'
               | |:|| :: |::||||| 
Target 5' catgtGTGTCCTGGTGTTCCCAGc 3'
304 - 327 127.00 -20.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28196156 34 COSMIC
COSN31550408 39 COSMIC
COSN31576174 43 COSMIC
COSN28196146 64 COSMIC
COSN30497075 77 COSMIC
COSN31531111 103 COSMIC
COSN30532487 133 COSMIC
COSN31588878 175 COSMIC
COSN15662987 618 COSMIC
COSN25838481 994 COSMIC
COSN20965736 1003 COSMIC
COSN7302113 1338 COSMIC
COSN1695740 1356 COSMIC
COSN20626700 1405 COSMIC
COSN20676202 1532 COSMIC
COSN24279872 1681 COSMIC
COSN25720337 1716 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746327360 2 dbSNP
rs1189144441 7 dbSNP
rs772751358 8 dbSNP
rs376761785 9 dbSNP
rs761471485 13 dbSNP
rs1223963838 14 dbSNP
rs769508433 14 dbSNP
rs1467593180 19 dbSNP
rs777132064 20 dbSNP
rs368033051 21 dbSNP
rs766120944 23 dbSNP
rs374043839 26 dbSNP
rs759371495 27 dbSNP
rs767502488 30 dbSNP
rs1268548423 32 dbSNP
rs189703997 34 dbSNP
rs1219090431 36 dbSNP
rs756199019 41 dbSNP
rs1400090392 43 dbSNP
rs1321084303 48 dbSNP
rs371391701 51 dbSNP
rs1278849583 52 dbSNP
rs1450686461 56 dbSNP
rs1182158311 57 dbSNP
rs1407562818 65 dbSNP
rs1365305054 70 dbSNP
rs1468448428 71 dbSNP
rs770353839 77 dbSNP
rs1258722614 78 dbSNP
rs1418518575 79 dbSNP
rs1484999871 82 dbSNP
rs1025032784 86 dbSNP
rs1287514557 91 dbSNP
rs1215910774 102 dbSNP
rs1463027919 103 dbSNP
rs1323979501 104 dbSNP
rs1315920422 105 dbSNP
rs970511532 107 dbSNP
rs1001870084 114 dbSNP
rs1313849637 118 dbSNP
rs1355841191 122 dbSNP
rs1292522560 126 dbSNP
rs1412828130 128 dbSNP
rs1033386963 129 dbSNP
rs777084475 130 dbSNP
rs1290662994 134 dbSNP
rs1392166605 140 dbSNP
rs760058825 144 dbSNP
rs933359333 150 dbSNP
rs983907273 151 dbSNP
rs1463271523 152 dbSNP
rs983571558 160 dbSNP
rs531998268 161 dbSNP
rs1228195515 164 dbSNP
rs1294390009 172 dbSNP
rs1337596521 188 dbSNP
rs1186525544 200 dbSNP
rs1234514278 206 dbSNP
rs1037914885 220 dbSNP
rs552266055 225 dbSNP
rs565613662 232 dbSNP
rs961567406 233 dbSNP
rs895394399 234 dbSNP
rs1487903360 242 dbSNP
rs948295225 246 dbSNP
rs1296221494 250 dbSNP
rs972106959 257 dbSNP
rs1356832013 263 dbSNP
rs1381632262 269 dbSNP
rs1361350367 270 dbSNP
rs79965049 271 dbSNP
rs1287230697 272 dbSNP
rs146030951 275 dbSNP
rs1003009355 276 dbSNP
rs568662712 276 dbSNP
rs1460210304 282 dbSNP
rs1375228679 290 dbSNP
rs114568350 292 dbSNP
rs891569682 296 dbSNP
rs1416738819 314 dbSNP
rs1011361078 315 dbSNP
rs1468607383 322 dbSNP
rs1435817424 324 dbSNP
rs542343127 324 dbSNP
rs910624785 334 dbSNP
rs1181206543 336 dbSNP
rs1211525850 338 dbSNP
rs1021447946 342 dbSNP
rs557346338 343 dbSNP
rs974687658 346 dbSNP
rs1293460336 347 dbSNP
rs562005808 348 dbSNP
rs570856387 349 dbSNP
rs1325494604 354 dbSNP
rs1162777935 360 dbSNP
rs1439057346 365 dbSNP
rs1299139011 366 dbSNP
rs1399078864 366 dbSNP
rs539413178 367 dbSNP
rs945585914 376 dbSNP
rs1046067481 377 dbSNP
rs906231495 378 dbSNP
rs553453842 380 dbSNP
rs1001817893 385 dbSNP
rs1033419609 388 dbSNP
rs751747031 393 dbSNP
rs907958289 409 dbSNP
rs1394630331 410 dbSNP
rs1250942151 428 dbSNP
rs1195029829 437 dbSNP
rs73490247 443 dbSNP
rs1257692919 446 dbSNP
rs1213042537 448 dbSNP
rs1313871594 458 dbSNP
rs1302858780 461 dbSNP
rs761909168 467 dbSNP
rs1232331913 472 dbSNP
rs973535935 486 dbSNP
rs1005361766 488 dbSNP
rs373826341 489 dbSNP
rs1046657289 490 dbSNP
rs906809037 497 dbSNP
rs961328777 499 dbSNP
rs11552572 502 dbSNP
rs753802130 508 dbSNP
rs1171251782 510 dbSNP
rs1320553968 515 dbSNP
rs1454977098 519 dbSNP
rs772045018 525 dbSNP
rs1364048086 527 dbSNP
rs1180741145 530 dbSNP
rs554382376 531 dbSNP
rs1259424286 536 dbSNP
rs1029570053 546 dbSNP
rs954901126 547 dbSNP
rs891538644 553 dbSNP
rs1279676232 555 dbSNP
rs574271713 561 dbSNP
rs986110568 562 dbSNP
rs910657268 569 dbSNP
rs1353069134 571 dbSNP
rs1021372722 575 dbSNP
rs1238712993 575 dbSNP
rs1339642903 577 dbSNP
rs1334344181 579 dbSNP
rs900361038 584 dbSNP
rs1415910680 586 dbSNP
rs936709502 587 dbSNP
rs996466186 592 dbSNP
rs376935289 594 dbSNP
rs914017075 595 dbSNP
rs563403314 597 dbSNP
rs1157619960 598 dbSNP
rs945563273 599 dbSNP
rs1419724424 600 dbSNP
rs1165445296 605 dbSNP
rs954830419 606 dbSNP
rs1185669984 607 dbSNP
rs983466121 611 dbSNP
rs1448832687 615 dbSNP
rs1014943456 625 dbSNP
rs532155074 630 dbSNP
rs755002224 631 dbSNP
rs916722375 633 dbSNP
rs139949328 634 dbSNP
rs1291991656 635 dbSNP
rs778844511 638 dbSNP
rs752595287 639 dbSNP
rs1326503789 641 dbSNP
rs1317071874 648 dbSNP
rs928233711 650 dbSNP
rs1396254411 653 dbSNP
rs1326291265 654 dbSNP
rs527907894 655 dbSNP
rs1415508953 659 dbSNP
rs528237255 661 dbSNP
rs1802723 664 dbSNP
rs888211227 669 dbSNP
rs1052683751 673 dbSNP
rs1373692030 673 dbSNP
rs1463678521 677 dbSNP
rs912901626 682 dbSNP
rs1377623494 684 dbSNP
rs1005227456 699 dbSNP
rs1015338434 700 dbSNP
rs1468308838 705 dbSNP
rs897011949 718 dbSNP
rs998014429 724 dbSNP
rs1363287735 725 dbSNP
rs1042800044 727 dbSNP
rs1269032413 730 dbSNP
rs1225592026 742 dbSNP
rs1382234327 742 dbSNP
rs1372641902 744 dbSNP
rs548301773 747 dbSNP
rs568697259 748 dbSNP
rs1439787393 749 dbSNP
rs1391970453 756 dbSNP
rs900277609 762 dbSNP
rs1410412035 765 dbSNP
rs1395720130 767 dbSNP
rs1297095056 768 dbSNP
rs1362476538 770 dbSNP
rs1397029384 771 dbSNP
rs541219732 778 dbSNP
rs1454031093 787 dbSNP
rs1052068157 793 dbSNP
rs531108030 805 dbSNP
rs1438861236 806 dbSNP
rs1272932982 808 dbSNP
rs1202340375 825 dbSNP
rs192944609 829 dbSNP
rs1280512152 831 dbSNP
rs1017583293 832 dbSNP
rs1233077714 840 dbSNP
rs1349732386 847 dbSNP
rs958111564 850 dbSNP
rs1281028494 852 dbSNP
rs1442666280 854 dbSNP
rs777415748 855 dbSNP
rs990010373 857 dbSNP
rs1326752410 864 dbSNP
rs1436575779 869 dbSNP
rs1014912429 870 dbSNP
rs1174393246 871 dbSNP
rs1434289531 873 dbSNP
rs76327579 878 dbSNP
rs539822894 879 dbSNP
rs1470726689 880 dbSNP
rs1232726534 882 dbSNP
rs1023708986 884 dbSNP
rs982284871 885 dbSNP
rs142081758 889 dbSNP
rs982292824 899 dbSNP
rs1448988177 903 dbSNP
rs3810795 909 dbSNP
rs928127960 910 dbSNP
rs1285927455 913 dbSNP
rs1224048273 921 dbSNP
rs1054729401 930 dbSNP
rs1194462858 932 dbSNP
rs566517527 935 dbSNP
rs1452903075 945 dbSNP
rs535583469 951 dbSNP
rs555425979 954 dbSNP
rs766071562 955 dbSNP
rs1455793393 956 dbSNP
rs1447400080 960 dbSNP
rs780730595 961 dbSNP
rs1161540739 962 dbSNP
rs1401575748 973 dbSNP
rs151141585 976 dbSNP
rs1385769091 985 dbSNP
rs998443941 986 dbSNP
rs1433753882 987 dbSNP
rs536821997 990 dbSNP
rs1050918234 994 dbSNP
rs1258868019 995 dbSNP
rs184054887 1001 dbSNP
rs1006772744 1003 dbSNP
rs577025745 1004 dbSNP
rs958059294 1014 dbSNP
rs1317355152 1018 dbSNP
rs1010894413 1020 dbSNP
rs1241065586 1032 dbSNP
rs546071489 1043 dbSNP
rs966797060 1044 dbSNP
rs890303665 1048 dbSNP
rs1004776839 1050 dbSNP
rs1431687060 1055 dbSNP
rs1388190542 1056 dbSNP
rs1318911651 1059 dbSNP
rs1036270117 1067 dbSNP
rs559133661 1067 dbSNP
rs1383608159 1069 dbSNP
rs982702374 1070 dbSNP
rs1255049415 1073 dbSNP
rs928104104 1075 dbSNP
rs959620451 1080 dbSNP
rs1421010327 1086 dbSNP
rs991073663 1092 dbSNP
rs994834951 1093 dbSNP
rs1245847380 1094 dbSNP
rs1487626978 1103 dbSNP
rs1272358888 1106 dbSNP
rs1309242711 1112 dbSNP
rs1297733901 1113 dbSNP
rs1215278261 1117 dbSNP
rs910120770 1129 dbSNP
rs1024088936 1135 dbSNP
rs775823299 1142 dbSNP
rs1004037238 1143 dbSNP
rs1456788013 1160 dbSNP
rs1356792622 1161 dbSNP
rs572852534 1163 dbSNP
rs1421291122 1166 dbSNP
rs1036673478 1169 dbSNP
rs918351470 1173 dbSNP
rs541978756 1178 dbSNP
rs1195075953 1182 dbSNP
rs1454491560 1199 dbSNP
rs1035171586 1203 dbSNP
rs933717819 1207 dbSNP
rs1022021989 1208 dbSNP
rs1051379437 1209 dbSNP
rs1189258972 1210 dbSNP
rs561729513 1213 dbSNP
rs1456194318 1214 dbSNP
rs1203794490 1219 dbSNP
rs1341510472 1228 dbSNP
rs75680089 1233 dbSNP
rs1175033655 1234 dbSNP
rs1376103308 1234 dbSNP
rs1390046639 1234 dbSNP
rs1425835788 1234 dbSNP
rs1429714144 1234 dbSNP
rs1434884552 1234 dbSNP
rs562145171 1234 dbSNP
rs571951905 1234 dbSNP
rs988296368 1235 dbSNP
rs1325997416 1238 dbSNP
rs1396118201 1253 dbSNP
rs1433831622 1255 dbSNP
rs1292632061 1256 dbSNP
rs1373743029 1260 dbSNP
rs1392946806 1264 dbSNP
rs968215379 1265 dbSNP
rs1251026950 1268 dbSNP
rs531146892 1269 dbSNP
rs986281533 1271 dbSNP
rs1275113402 1273 dbSNP
rs1249641173 1274 dbSNP
rs1320049327 1274 dbSNP
rs550848660 1275 dbSNP
rs113705886 1276 dbSNP
rs113141391 1277 dbSNP
rs968307347 1278 dbSNP
rs1006725440 1279 dbSNP
rs1481795189 1286 dbSNP
rs921598425 1296 dbSNP
rs1054397427 1297 dbSNP
rs1314141713 1299 dbSNP
rs1414895810 1312 dbSNP
rs1400933386 1320 dbSNP
rs1170416187 1324 dbSNP
rs754886949 1327 dbSNP
rs987643030 1328 dbSNP
rs1158166887 1332 dbSNP
rs911677633 1334 dbSNP
rs1419977402 1335 dbSNP
rs1190095726 1340 dbSNP
rs1443050013 1351 dbSNP
rs1255604392 1352 dbSNP
rs940489327 1353 dbSNP
rs1261619612 1372 dbSNP
rs564810369 1375 dbSNP
rs1011336179 1377 dbSNP
rs1327645859 1378 dbSNP
rs899073149 1379 dbSNP
rs1415298223 1380 dbSNP
rs1020929205 1387 dbSNP
rs967198143 1388 dbSNP
rs1331697632 1395 dbSNP
rs1003594721 1396 dbSNP
rs1383500167 1397 dbSNP
rs1035056876 1399 dbSNP
rs1455463657 1400 dbSNP
rs959558093 1401 dbSNP
rs1396473536 1408 dbSNP
rs1165520585 1409 dbSNP
rs533495240 1410 dbSNP
rs1305951919 1411 dbSNP
rs1248908819 1413 dbSNP
rs139107867 1413 dbSNP
rs1430451738 1413 dbSNP
rs1208404738 1415 dbSNP
rs149900630 1419 dbSNP
rs535424414 1420 dbSNP
rs1275517177 1422 dbSNP
rs1210946544 1427 dbSNP
rs1415300736 1432 dbSNP
rs1035502045 1443 dbSNP
rs147579473 1445 dbSNP
rs1227831566 1450 dbSNP
rs568963761 1451 dbSNP
rs933643731 1456 dbSNP
rs1022428495 1461 dbSNP
rs767670799 1465 dbSNP
rs1326394343 1470 dbSNP
rs142557915 1473 dbSNP
rs942538593 1474 dbSNP
rs1274348796 1478 dbSNP
rs1390912816 1481 dbSNP
rs35354174 1482 dbSNP
rs556918998 1482 dbSNP
rs576966803 1483 dbSNP
rs953151690 1485 dbSNP
rs529186585 1498 dbSNP
rs1451498275 1503 dbSNP
rs1288377085 1508 dbSNP
rs1198131396 1513 dbSNP
rs1342212727 1517 dbSNP
rs1471492957 1519 dbSNP
rs1180780793 1520 dbSNP
rs945944675 1522 dbSNP
rs755954398 1523 dbSNP
rs1329186649 1530 dbSNP
rs902544167 1538 dbSNP
rs1330779366 1541 dbSNP
rs1003948955 1547 dbSNP
rs1035099191 1548 dbSNP
rs765208647 1549 dbSNP
rs1427991962 1554 dbSNP
rs752685266 1556 dbSNP
rs1369683643 1561 dbSNP
rs1477891826 1571 dbSNP
rs758172510 1575 dbSNP
rs971855827 1582 dbSNP
rs1245384471 1592 dbSNP
rs1017020512 1595 dbSNP
rs1435137612 1602 dbSNP
rs1336038675 1606 dbSNP
rs1357373381 1620 dbSNP
rs1447298777 1621 dbSNP
rs777452114 1622 dbSNP
rs539378175 1623 dbSNP
rs751204175 1646 dbSNP
rs1045400384 1649 dbSNP
rs1342612059 1658 dbSNP
rs756901012 1669 dbSNP
rs1364239851 1670 dbSNP
rs1226426596 1673 dbSNP
rs905137105 1674 dbSNP
rs1349804887 1676 dbSNP
rs939329069 1681 dbSNP
rs955090460 1682 dbSNP
rs986451833 1685 dbSNP
rs780679252 1687 dbSNP
rs531194758 1690 dbSNP
rs1414186681 1698 dbSNP
rs755638356 1699 dbSNP
rs1160666765 1700 dbSNP
rs1442349256 1705 dbSNP
rs892518142 1707 dbSNP
rs1217204875 1709 dbSNP
rs989983778 1713 dbSNP
rs146684439 1715 dbSNP
rs568870077 1716 dbSNP
rs575369544 1723 dbSNP
rs1041672399 1724 dbSNP
rs1328329856 1725 dbSNP
rs1286357302 1730 dbSNP
rs1186237576 1742 dbSNP
rs1389191190 1750 dbSNP
rs1454507417 1753 dbSNP
rs1447498330 1762 dbSNP
rs997055777 1763 dbSNP
rs907103638 1765 dbSNP
rs1322916627 1766 dbSNP
rs1458112517 1767 dbSNP
rs1388425193 1771 dbSNP
rs1399881041 1779 dbSNP
rs749778424 1790 dbSNP
rs1413817565 1794 dbSNP
rs1180782401 1817 dbSNP
rs1413824898 1818 dbSNP
rs1243511918 1819 dbSNP
rs1209021425 1826 dbSNP
rs1056369764 1827 dbSNP
rs80290294 1832 dbSNP
rs1464249636 1833 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000397066.4 | 3UTR | AGAUGCUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000397066.4 | 3UTR | AGAUGCUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000397066.4 | 3UTR | AGAUGCUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.551 3.2e-3 0.654 3.6e-4 23 Click to see details
GSE26953 Aortic valvular endothelial cells -0.54 3.2e-3 -0.511 5.4e-3 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.393 2.6e-2 -0.281 8.7e-2 25 Click to see details
GSE14794 Lymphoblastoid cells -0.182 4.3e-2 -0.140 9.4e-2 90 Click to see details
GSE28260 Renal cortex and medulla 0.318 1.4e-1 0.214 2.4e-1 13 Click to see details
GSE17498 Multiple myeloma -0.143 1.9e-1 -0.135 2.0e-1 40 Click to see details
GSE32688 Pancreatic cancer 0.145 2.1e-1 0.271 6.7e-2 32 Click to see details
GSE27834 Pluripotent stem cells -0.159 2.8e-1 0.044 4.4e-1 16 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.128 3.0e-1 0.099 3.4e-1 20 Click to see details
GSE21687 Ependynoma primary tumors -0.061 3.2e-1 -0.049 3.5e-1 64 Click to see details
GSE21849 B cell lymphoma 0.086 3.3e-1 0.280 7.1e-2 29 Click to see details
GSE28544 Breast cancer -0.079 3.6e-1 0.034 4.4e-1 24 Click to see details
GSE38226 Liver fibrosis 0.062 3.9e-1 -0.036 4.4e-1 21 Click to see details
GSE17306 Multiple myeloma -0.025 4.3e-1 0.317 1.3e-2 49 Click to see details
GSE17306 Multiple myeloma -0.025 4.3e-1 0.317 1.3e-2 49 Click to see details
GSE17306 Multiple myeloma -0.025 4.3e-1 0.317 1.3e-2 49 Click to see details
GSE17306 Multiple myeloma -0.025 4.3e-1 0.317 1.3e-2 49 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-637 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006147 SP7 Sp7 transcription factor 3 1
MIRT054906 COL4A1 collagen type IV alpha 1 chain 1 1
MIRT159142 NRBP1 nuclear receptor binding protein 1 2 2
MIRT358526 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT441490 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT443472 ACPP acid phosphatase, prostate 2 2
MIRT464631 UBE4A ubiquitination factor E4A 2 2
MIRT465259 TRIM44 tripartite motif containing 44 2 2
MIRT473975 LRRC58 leucine rich repeat containing 58 2 2
MIRT475168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT477631 EFNA1 ephrin A1 2 2
MIRT480100 CALR calreticulin 2 2
MIRT483504 STMN3 stathmin 3 2 4
MIRT483735 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT483847 UNC5B unc-5 netrin receptor B 2 2
MIRT485973 RTBDN retbindin 2 2
MIRT486616 METTL6 methyltransferase like 6 2 2
MIRT487847 CLSTN1 calsyntenin 1 2 4
MIRT488675 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT489046 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT490612 SLC47A1 solute carrier family 47 member 1 2 4
MIRT490990 USP22 ubiquitin specific peptidase 22 2 2
MIRT492559 PRX periaxin 2 2
MIRT494667 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT495880 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT496778 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT499742 USH1G USH1 protein network component sans 2 4
MIRT500371 ZNF385A zinc finger protein 385A 2 2
MIRT503257 KIF18B kinesin family member 18B 2 2
MIRT504511 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT511940 FAM127B retrotransposon Gag like 8A 2 2
MIRT514606 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT527187 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT532494 HOXA13 homeobox A13 2 2
MIRT533504 TRIM71 tripartite motif containing 71 2 2
MIRT539171 AR androgen receptor 2 2
MIRT542735 RBFOX2 RNA binding protein, fox-1 homolog 2 2 2
MIRT544647 PHF8 PHD finger protein 8 2 4
MIRT546232 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 2
MIRT548372 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT555913 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT565381 TGOLN2 trans-golgi network protein 2 2 2
MIRT568954 RUNX3 runt related transcription factor 3 2 2
MIRT570205 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT573599 CERS1 ceramide synthase 1 2 2
MIRT615364 CCNF cyclin F 2 2
MIRT616102 HOXB5 homeobox B5 2 2
MIRT619127 CD40LG CD40 ligand 2 2
MIRT634968 C8orf17 chromosome 8 open reading frame 17 2 2
MIRT646665 FNBP1 formin binding protein 1 2 2
MIRT649633 RASA4 RAS p21 protein activator 4 2 2
MIRT658443 FAM167B family with sequence similarity 167 member B 2 2
MIRT660237 BMP7 bone morphogenetic protein 7 2 2
MIRT669467 ATL3 atlastin GTPase 3 2 2
MIRT670557 SHISA2 shisa family member 2 2 2
MIRT671035 PCDHB2 protocadherin beta 2 2 2
MIRT684255 TBXA2R thromboxane A2 receptor 2 2
MIRT688619 CYBRD1 cytochrome b reductase 1 3 2
MIRT694346 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT695516 ALPI alkaline phosphatase, intestinal 2 2
MIRT697512 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT700133 RNF144B ring finger protein 144B 2 2
MIRT711667 TRMT5 tRNA methyltransferase 5 2 2
MIRT712156 TAOK1 TAO kinase 1 2 2
MIRT712463 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT720759 FAM193A family with sequence similarity 193 member A 2 2
MIRT731198 AKT1 AKT serine/threonine kinase 1 2 1
MIRT755463 PACS2 phosphofurin acidic cluster sorting protein 2 1 1
MIRT755522 FOXM1 forkhead box M1 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-637 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-miR-637 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive Low Squamous Cell Carcinoma cell line (SCC-11)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-637 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Tivantinib 11494412 NSC758242 resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-637 Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, HCT-116)
hsa-miR-637 Sevoflurane 5206 NSC760367 approved sensitive Low Colorectal Cancer cell line
hsa-mir-637 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-637 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-637 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-637 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-637 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-637 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-637 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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