pre-miRNA Information | |
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pre-miRNA | hsa-mir-637 |
Genomic Coordinates | chr19: 3961414 - 3961512 |
Synonyms | MIRN637, hsa-mir-637, MIR637 |
Description | Homo sapiens miR-637 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-637 | |||||||||||||||||||||||||||||||||||||||
Sequence | 61| ACUGGGGGCUUUCGGGCUCUGCGU |84 | |||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||
Experiments | SAGE | |||||||||||||||||||||||||||||||||||||||
Expression Profile | ![]() |
DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | CCNF | ||||||||||||||||||||
Synonyms | FBX1, FBXO1 | ||||||||||||||||||||
Description | cyclin F | ||||||||||||||||||||
Transcript | NM_001761 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on CCNF | |||||||||||||||||||||
3'UTR of CCNF (miRNA target sites are highlighted) |
>CCNF|NM_001761|3'UTR 1 GTGTGTCAGCACATTTGCCGCAGTGGATGTGTACTGAGGGGGCTGGAGGCGAAGGGTGGGAGCATAGCATAGGAACGCTG 81 CATAGACCATGGAGGCCTTTGCGCAGAGAGCAGAGAGGATGACTTGCGGCCACCAAGTTTCTGTCTCCGCGGGAGTCCCG 161 TGCAAGCCATCAGAATGTTGAAATGAGGGTGAAGAGCTCAGATCCCTCTCTTTGGAAAGTTTAGCCTGGAAGCAGTTGGC 241 CACACTGTGTGGAGGGCACCTCTCTGTCCCTTCCGTGTCTCACTGTCTCTGGAAGCTTCAGCCCATGTGTGTCCTGGTGT 321 TCCCAGCCCCACCAGAGCCCCGTGCCGGGAGCTGACAGCTTTCACGCTTAAGGCACGTGTGACCTGGGTAGTCAGACACC 401 ACTTGAGCCCCTGCCCACATCTGCTGGTTTGGGGCTTCAGTGGGGAGCTGACAGCTGTGAGCACACCACTGTCCCCTCAT 481 CCACCTCGGCCTGCATGGGGCACCCACTTCCTTCTGGGTGGGGCTTCCATGGTAAGGGGGCCTGCGTCCCTGCACACTGC 561 GAGGACTGCCTTGGCCACAGGCCCACTCCCTACGACACGTGACTCGTTTTAGAGCTCTGTCCCAGAGGCGTTCGTATGTG 641 ACCCACAGATGGCGTCAATGTGAACACCTCTCTTTGTGCTGAATTTCTGGGCCATTCTTTTCCTGTCTTATTTCTAAATT 721 TCCTTCTTCCAAGATGAAAACAAAAGAAAAACTTAAAACAGAAGGTATTAAAAAAACAAGAGATTCCCACCATTATTTAG 801 GTTCACCTGCAAAACAAAAATCTTACTCCAGCCCCTCAATGCCATCCTGACACACTTTATGCAAAAAGAATTTTCCCAGA 881 TAGGCTAGCCAGAAAAAACTTCAAGTCCTCTGTAACATCTGAGGTGACCAAGAGGCAGAAGAGCAGAGCAGTCGGGGGCC 961 GTGTCCTGGCTGATCCCAACTGCAGCTCTGCTGTGGGGGCCCGTGGGAGGGAGGCAGACCCCTGGGCTTTCCTGCTGGCC 1041 ACGGAGACTCTGCTCCTGCATGGAAAGGGAGCCTGGGAGCCAGCAGCCCACGCCTGGGGAGCCTGCCTGGGGCCATGTGA 1121 CCATGGCCTCTCCCTGGGAACGGGCTGACCACAACACACCCTGCTGCCATCCACTTCTGTTTACTCTGCAAATGTAAGAA 1201 AGAACCACTTGGCCAGAAGTGTCCCCCAGATGCTTTTTTTTTTTTTTTTTTGGAGACAGTTTTGCTCTTGTCTCCCCGGC 1281 TGGAGTGCAGTGGCATGATCTCAACTCTCAACTCACTGTAACCTCCGCCTCCCGGATACTCCTGCCTCAGCCTCCTGGGT 1361 AGCTGGGATTACAAGCACCCAACCACGCCCAGCTAATTTTTGTATTTTCGGTAGAGACGGGATTTCACCATGTTGGCCAG 1441 GCTAGTCTCGAACTCATGACCTCAAGTGATCCGCCCACTTCGGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACGG 1521 CGCCTGGCCCCCAAATGCTCTTGAACCGGAAACCCAGGGATGGGAGATGCTCACTGAGCTGCTGCTTTTATGTGTGCTGG 1601 TGCTATGTGTGTTCATGTCCGCGGCAGCTGTCTTTTTGCTACTATAAGGGAATTCTGGCCACCCTGGGTGGGGTGTGGTC 1681 GGGGTGAGAACCCAAGCGTTGGAACTGTAGACCCGTCCTGTCGACTGTGTGCCCCTGGGCATGTGTGAGCCTCAGTTTCC 1761 TCATCTGTAAGGGGGGCAATGATACCTACCTCACAGGGGTGTTGTGAGGATTAAATGTGAGGAGGATAGTGGCAGATG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293S |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb
HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb
HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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CLIP-seq Support 1 for dataset GSM1084066 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_SantaCruzAb |
Location of target site | ENST00000397066.4 | 3UTR | AGAUGCUUUUUUUUUUUUU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1084078 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb |
Location of target site | ENST00000397066.4 | 3UTR | AGAUGCUUUUUUUUUUUUUUUU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM1084081 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb |
Location of target site | ENST00000397066.4 | 3UTR | AGAUGCUUUUUUUUUUUUUU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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69 hsa-miR-637 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT006147 | SP7 | Sp7 transcription factor | ![]() |
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3 | 1 | |||||
MIRT054906 | COL4A1 | collagen type IV alpha 1 chain | ![]() |
1 | 1 | |||||||
MIRT159142 | NRBP1 | nuclear receptor binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT358526 | HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | ![]() |
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2 | 2 | ||||||
MIRT441490 | NCEH1 | neutral cholesterol ester hydrolase 1 | ![]() |
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2 | 2 | ||||||
MIRT443472 | ACPP | acid phosphatase, prostate | ![]() |
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2 | 2 | ||||||
MIRT464631 | UBE4A | ubiquitination factor E4A | ![]() |
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2 | 2 | ||||||
MIRT465259 | TRIM44 | tripartite motif containing 44 | ![]() |
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2 | 2 | ||||||
MIRT473975 | LRRC58 | leucine rich repeat containing 58 | ![]() |
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2 | 2 | ||||||
MIRT475168 | IP6K1 | inositol hexakisphosphate kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT477631 | EFNA1 | ephrin A1 | ![]() |
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2 | 2 | ||||||
MIRT480100 | CALR | calreticulin | ![]() |
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2 | 2 | ||||||
MIRT483504 | STMN3 | stathmin 3 | ![]() |
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2 | 4 | ||||||
MIRT483735 | THSD4 | thrombospondin type 1 domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT483847 | UNC5B | unc-5 netrin receptor B | ![]() |
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2 | 2 | ||||||
MIRT485973 | RTBDN | retbindin | ![]() |
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2 | 2 | ||||||
MIRT486616 | METTL6 | methyltransferase like 6 | ![]() |
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2 | 2 | ||||||
MIRT487847 | CLSTN1 | calsyntenin 1 | ![]() |
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2 | 4 | ||||||
MIRT488675 | WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | ![]() |
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2 | 4 | ||||||
MIRT489046 | PRPF4B | pre-mRNA processing factor 4B | ![]() |
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2 | 2 | ||||||
MIRT490612 | SLC47A1 | solute carrier family 47 member 1 | ![]() |
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2 | 4 | ||||||
MIRT490990 | USP22 | ubiquitin specific peptidase 22 | ![]() |
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2 | 2 | ||||||
MIRT492559 | PRX | periaxin | ![]() |
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2 | 2 | ||||||
MIRT494667 | ARL8A | ADP ribosylation factor like GTPase 8A | ![]() |
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2 | 2 | ||||||
MIRT495880 | DPY19L1 | dpy-19 like C-mannosyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT496778 | ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif 14 | ![]() |
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2 | 2 | ||||||
MIRT499742 | USH1G | USH1 protein network component sans | ![]() |
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2 | 4 | ||||||
MIRT500371 | ZNF385A | zinc finger protein 385A | ![]() |
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2 | 2 | ||||||
MIRT503257 | KIF18B | kinesin family member 18B | ![]() |
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2 | 2 | ||||||
MIRT504511 | PPP1R9B | protein phosphatase 1 regulatory subunit 9B | ![]() |
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2 | 2 | ||||||
MIRT511940 | FAM127B | retrotransposon Gag like 8A | ![]() |
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2 | 2 | ||||||
MIRT514606 | NDUFA12 | NADH:ubiquinone oxidoreductase subunit A12 | ![]() |
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2 | 4 | ||||||
MIRT527187 | CLASP1 | cytoplasmic linker associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT532494 | HOXA13 | homeobox A13 | ![]() |
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2 | 2 | ||||||
MIRT533504 | TRIM71 | tripartite motif containing 71 | ![]() |
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2 | 2 | ||||||
MIRT539171 | AR | androgen receptor | ![]() |
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2 | 2 | ||||||
MIRT542735 | RBFOX2 | RNA binding protein, fox-1 homolog 2 | ![]() |
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2 | 2 | ||||||
MIRT544647 | PHF8 | PHD finger protein 8 | ![]() |
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2 | 4 | ||||||
MIRT546232 | TNRC18P2 | trinucleotide repeat containing 18 pseudogene 2 | ![]() |
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2 | 2 | ||||||
MIRT548372 | ENTPD5 | ectonucleoside triphosphate diphosphohydrolase 5 | ![]() |
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2 | 4 | ||||||
MIRT555913 | ORMDL3 | ORMDL sphingolipid biosynthesis regulator 3 | ![]() |
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2 | 2 | ||||||
MIRT565381 | TGOLN2 | trans-golgi network protein 2 | ![]() |
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2 | 2 | ||||||
MIRT568954 | RUNX3 | runt related transcription factor 3 | ![]() |
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2 | 2 | ||||||
MIRT570205 | RAP1GAP2 | RAP1 GTPase activating protein 2 | ![]() |
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2 | 2 | ||||||
MIRT573599 | CERS1 | ceramide synthase 1 | ![]() |
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2 | 2 | ||||||
MIRT615364 | CCNF | cyclin F | ![]() |
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2 | 2 | ||||||
MIRT616102 | HOXB5 | homeobox B5 | ![]() |
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2 | 2 | ||||||
MIRT619127 | CD40LG | CD40 ligand | ![]() |
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2 | 2 | ||||||
MIRT634968 | C8orf17 | chromosome 8 open reading frame 17 | ![]() |
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2 | 2 | ||||||
MIRT646665 | FNBP1 | formin binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT649633 | RASA4 | RAS p21 protein activator 4 | ![]() |
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2 | 2 | ||||||
MIRT658443 | FAM167B | family with sequence similarity 167 member B | ![]() |
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2 | 2 | ||||||
MIRT660237 | BMP7 | bone morphogenetic protein 7 | ![]() |
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2 | 2 | ||||||
MIRT669467 | ATL3 | atlastin GTPase 3 | ![]() |
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2 | 2 | ||||||
MIRT670557 | SHISA2 | shisa family member 2 | ![]() |
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2 | 2 | ||||||
MIRT671035 | PCDHB2 | protocadherin beta 2 | ![]() |
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2 | 2 | ||||||
MIRT684255 | TBXA2R | thromboxane A2 receptor | ![]() |
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2 | 2 | ||||||
MIRT688619 | CYBRD1 | cytochrome b reductase 1 | ![]() |
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3 | 2 | |||||
MIRT694346 | CHST6 | carbohydrate sulfotransferase 6 | ![]() |
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2 | 2 | ||||||
MIRT695516 | ALPI | alkaline phosphatase, intestinal | ![]() |
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2 | 2 | ||||||
MIRT697512 | ZBTB7A | zinc finger and BTB domain containing 7A | ![]() |
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2 | 2 | ||||||
MIRT700133 | RNF144B | ring finger protein 144B | ![]() |
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2 | 2 | ||||||
MIRT711667 | TRMT5 | tRNA methyltransferase 5 | ![]() |
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2 | 2 | ||||||
MIRT712156 | TAOK1 | TAO kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT712463 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ![]() |
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2 | 2 | ||||||
MIRT720759 | FAM193A | family with sequence similarity 193 member A | ![]() |
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2 | 2 | ||||||
MIRT731198 | AKT1 | AKT serine/threonine kinase 1 | ![]() |
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2 | 1 | ||||||
MIRT755463 | PACS2 | phosphofurin acidic cluster sorting protein 2 | 1 | 1 | ||||||||
MIRT755522 | FOXM1 | forkhead box M1 | 3 | 1 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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