miRTarBase - #MIRT615500


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pre-miRNA Information
pre-miRNA hsa-mir-6767   
Genomic Coordinates chr16: 2445392 - 2445457
Description Homo sapiens miR-6767 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6767-3p
Sequence 45| CCACGUGCUUCUCUUUCCGCAG |66
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
722753 18 ClinVar
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1357663597 2 dbSNP
rs1195774168 3 dbSNP
rs1271299527 4 dbSNP
rs368889723 5 dbSNP
rs373559092 15 dbSNP
rs376429792 18 dbSNP
rs189194179 19 dbSNP
rs1189692059 22 dbSNP
Putative Targets

Gene Information
Gene Symbol MPP2   
Synonyms DLG2
Description membrane palmitoylated protein 2
Transcript NM_005374   
Expression
Putative miRNA Targets on MPP2
3'UTR of MPP2
(miRNA target sites are highlighted)		 
>MPP2|NM_005374|3'UTR
   1 GCCTGTTCACCTGGTCTTTGGCTCACTCTGTGTTGAAACCCAGAACCTGAATCCATCCCCCTCCTGACCTGTGACCCCCT
  81 GCCACAATCCTTAGCCCCCATATCTGGCTGTCCTTGGGTAACAGCTCCCAGCAGGCCCTAAGTCTGGCTTCAGCACAGAG
 161 GCGTGCACTGCCAGGGAGGTGGGCATTCATGGGGTACCTTGTGCCCAGGTGCTGCCCACTCCTGATGCCCATTGGTCACC
 241 AGATATCTCTGAGGGCCAAGCTATGCCCAGGAATGTGTCAGAGTCACCTCCATAATGGTCAGTACAGAGAAGAGAAAAGC
 321 TGCTTTGGGACCACATGGTCAGTAGGCACACTGCCCCCTGCCACCCCTCCCCAGTCACCAGTTCTCCTCTGGACTGGCCA
 401 CACCCACCCCATTCCTGGACTCCTCCCACCTCTCACCCCTGTGTCGGAGGAACAGGCCTTGGGCTGTTTCCGTGTGACCA
 481 GGGGAATGTGTGGCCCGCTGGCAGCCAGGCAGGCCCGGGTGGTGGTGCCAGCCTGGTGCCATCTTGAAGGCTGGAGGAGT
 561 CAGAGTGAGAGCTAGTGGCCACAGCTGCAGAGCACTGCAGCTCCCAGCTCCTTTGGAAAGGGACAGGGTCGCAGGGCAGA
 641 TGCTGCTCGGTCCTTCCCTCATCCACAGCTTCTCACTGCCGAAGTTTCTCCAGATTTCTCCAATGTGTCCTGACAGGTCA
 721 GCCCTGCTCCCCACAGGGCCAGGCTGGCAGGGGCCAGTGGGCTCAGCCCAGGTAGGGGCAGGATGGAGGGCTGAGCCCTG
 801 TGACAACCTGCTGTTACCAACTGAAGAGCCCCAAGCTCTCCATGGCCCACAGCAGGCACAGGTCTGAGCTCTATGTCCTT
 881 GACCTTGGTCCATTTGGTTTTCTGTCTAGCCAGGTCCAGGTAGCCCACTTGCATCAGGGCTGCTGGGTTGGAGGGGCTAA
 961 GGAGGAGTGCAGAGGGGACCTTGGGAGCCTGGGCTTGAAGGACAGTTGCCCTCCAGGAGGTTCCTCACACACAACTCCAG
1041 AGGCGCCATTTACACTGTAGTCTGTACAACCTGTGGTTCCACGTGCATGTTCGGCACCTGTCTGTGCCTCTGGCACCAGG
1121 TTGTGTGTATGTGTGTGCGTGTGCACGTGCGTGTGTGTGTGTGTGTGTCAGGTTTAATTTGGGGAGGAAGCAAAGGGTTT
1201 TGTTTTGGAGGTCACTCTTTGGGGCCCCTTTCTGGGGGTTCCCCATCAGCCCTCATTTCTTATAATACCCTGATCCCAGA
1281 CTCCAAAGCCCTGGTCCTTTCCTGATGTCTCCTCCCTTGTCTTATTGTCCCCCTACCCTAAATGCCCCCCTGCCATAACT
1361 TGGGGAGGGCAGTTTTGTAAAATAGGAGACTCCCTTTAAGAAAGAATGCTGTCCTAGATGTACTTGGGCATCTCATCCTT
1441 CATTATTCTCTGCATTCCTTCCGGGGGGAGCCTGTCCTCAGAGGGGACAACCTGTGACACCCTGAGTCCAAACCCTTGTG
1521 CCTCCCAGTTCTTCCAAGTGTCTAACTAGTCTTCGCTGCAGCGTCAGCCAAAGCTGGCCCCTGAACCACTGTGTGCCCAT
1601 TTCCTAGGGAAGGGGAAGGAGAATAAACAGAATATTTATTACAAATGTTAGAATATATTTCTTATACTAGGAATCTCATT
1681 TGCATTTGCATAGACTATACACATGGGGTGGAAAGGCCAGGCCTGCCCCCATCTCGTTGGTGTGGCTCTGCGTATACTAC
1761 ACACTCATTCTCCTGCTCCTCTTTTCCCTTAGTCAGTGTCCTTTCATCCTGATTCAGCTCTGCCTTGCATCACCCTCAGC
1841 CTAAGGGAGTGGGAAGGAAATGGGGTGTTTTCTTGCTGACCTGAGGCTATAGGGTCACTTGCCATTTCCTACCTTCTCTG
1921 GGGGATTTGAGGGTAGAGGCAGGGGAAGATCTGTTGTTGCAGCTGCTTCTGCCCCCTTGATCCAAATGACCATCATCTCT
2001 GATGGAGATGGGTTGGGTACCTGGCCTTCATGGCACCTTCACTGCTAGGGATGCTCAAGGGGCAGGCCTGGGGCCCTTCC
2081 CTCCTGTCTCTTCTCGGTCTTTCCTCTCTGAGCAGCCTCCTACCTCCCCTGCCTGAGCCCTCACTCCACAGCCCTCCCAG
2161 GTACCTAGCAGAGGCTGTCAGTCCTTGGCTCACCTGGAACAGGGCTGGGGCTGGGTTGGAACAGGTGTGTGCCCCCACCA
2241 CAGCTCTATGACTCTGTTCTCCCTCCCTGCCATTGTGGACTCTTGTATTTGAGGGACCTCAAGAGAGTGAGGACCCTACC
2321 ATCCACTGTCCATATTCAGTCCCAGCCCCAGTGCGCTTCCTCTGTTCCCTCCCTCAGCCATCCAATTCTTGAGTTTTCTC
2401 ACTGATTGGTTTTCTTTCTTTTTCCTTGGATTAAATGTGAAAGCAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
2481 AAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacgccuuucucuuCGUGCACc 5'
                        ||||||| 
Target 5' atgtgtgtgcgtgtGCACGTGc 3'
 1129 - 1150 140.00 -13.17
2 
miRNA  3' gacgccuuucucuucGUGCACc 5'
                         |||||| 
Target 5' tacaacctgtggttcCACGTGc 3'
 1065 - 1086 120.00 -14.10
3 
miRNA  3' gaCGCCUUUCUCUUCGUGCACc 5'
            |:| :|  ||::| |:||| 
Target 5' ccGTGTGACCAGGGGAATGTGt 3'
 470 - 491 112.00 -12.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30116560 20 COSMIC
COSN32059263 28 COSMIC
COSN30171259 69 COSMIC
COSN30160919 74 COSMIC
COSN30165334 79 COSMIC
COSN30165327 89 COSMIC
COSN30183465 90 COSMIC
COSN31573290 104 COSMIC
COSN30178482 110 COSMIC
COSN30544520 131 COSMIC
COSN31542096 161 COSMIC
COSN29234212 162 COSMIC
COSN31494984 174 COSMIC
COSN31495173 184 COSMIC
COSN8603196 196 COSMIC
COSN8836981 520 COSMIC
COSN26556029 630 COSMIC
COSN7435778 681 COSMIC
COSN30542712 699 COSMIC
COSN26596579 730 COSMIC
COSN17241226 758 COSMIC
COSN20113975 1126 COSMIC
COSN27605673 1328 COSMIC
COSN27612497 1344 COSMIC
COSN27794418 1398 COSMIC
COSN20180927 1462 COSMIC
COSN30176843 1481 COSMIC
COSN31515488 1661 COSMIC
COSN27150508 1684 COSMIC
COSN7435777 1752 COSMIC
COSN17037524 2083 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747618909 3 dbSNP
rs370806097 10 dbSNP
rs767092992 11 dbSNP
rs185479897 13 dbSNP
rs776391063 14 dbSNP
rs571726206 16 dbSNP
rs231521 17 dbSNP
rs369643176 21 dbSNP
rs775312520 24 dbSNP
rs765397685 26 dbSNP
rs1444624448 30 dbSNP
rs780810623 34 dbSNP
rs1294719729 36 dbSNP
rs1465686115 39 dbSNP
rs759848874 41 dbSNP
rs1219359590 47 dbSNP
rs1162223180 49 dbSNP
rs59817478 52 dbSNP
rs567979372 57 dbSNP
rs1202719125 63 dbSNP
rs992061317 68 dbSNP
rs1465472425 76 dbSNP
rs1433421934 82 dbSNP
rs967866104 83 dbSNP
rs1240619815 85 dbSNP
rs1023581163 87 dbSNP
rs1025443472 95 dbSNP
rs995346276 97 dbSNP
rs1479750651 98 dbSNP
rs1012562043 100 dbSNP
rs772348531 127 dbSNP
rs1451253444 132 dbSNP
rs549350257 135 dbSNP
rs1315764093 152 dbSNP
rs1018397765 153 dbSNP
rs1436573322 158 dbSNP
rs1035113462 162 dbSNP
rs527694631 163 dbSNP
rs1466495549 166 dbSNP
rs1330909157 181 dbSNP
rs1226396801 182 dbSNP
rs1282407464 196 dbSNP
rs1446707996 197 dbSNP
rs764869631 201 dbSNP
rs1372234348 206 dbSNP
rs1489991754 211 dbSNP
rs1199293641 214 dbSNP
rs1253232926 215 dbSNP
rs896910804 216 dbSNP
rs1473771038 218 dbSNP
rs1168038740 219 dbSNP
rs1405605727 221 dbSNP
rs566919894 222 dbSNP
rs1363199699 225 dbSNP
rs761476970 226 dbSNP
rs1005706888 229 dbSNP
rs1051545306 230 dbSNP
rs1010407474 243 dbSNP
rs1439746559 247 dbSNP
rs551564949 248 dbSNP
rs1250096393 250 dbSNP
rs1278744807 251 dbSNP
rs1189506311 253 dbSNP
rs892057635 258 dbSNP
rs889936677 259 dbSNP
rs1221922372 263 dbSNP
rs533504919 266 dbSNP
rs1484327925 268 dbSNP
rs1180028865 271 dbSNP
rs572086331 282 dbSNP
rs1232683820 284 dbSNP
rs564899988 287 dbSNP
rs1472897456 288 dbSNP
rs1183204152 294 dbSNP
rs1383050971 301 dbSNP
rs1423438938 302 dbSNP
rs1054545970 306 dbSNP
rs934255289 308 dbSNP
rs1460888447 317 dbSNP
rs543624947 338 dbSNP
rs1202632131 343 dbSNP
rs936214845 345 dbSNP
rs1053533633 348 dbSNP
rs925006442 349 dbSNP
rs1450011399 352 dbSNP
rs1044850409 354 dbSNP
rs947809310 355 dbSNP
rs531454984 356 dbSNP
rs1275454653 358 dbSNP
rs1342031522 359 dbSNP
rs901417685 363 dbSNP
rs1272976547 364 dbSNP
rs951242613 370 dbSNP
rs918541061 371 dbSNP
rs973898526 382 dbSNP
rs761532365 383 dbSNP
rs1018761193 387 dbSNP
rs1188579073 399 dbSNP
rs560859639 403 dbSNP
rs926061770 421 dbSNP
rs1167237577 422 dbSNP
rs1344821573 425 dbSNP
rs1029632160 426 dbSNP
rs1415954669 429 dbSNP
rs1334447267 431 dbSNP
rs1010229296 435 dbSNP
rs1452226051 437 dbSNP
rs892046455 439 dbSNP
rs555437092 440 dbSNP
rs1054661564 445 dbSNP
rs1225403016 446 dbSNP
rs1338129068 453 dbSNP
rs192640487 454 dbSNP
rs1346414415 455 dbSNP
rs967900395 456 dbSNP
rs916420944 462 dbSNP
rs990642060 463 dbSNP
rs906003475 471 dbSNP
rs1460569844 473 dbSNP
rs1208932785 474 dbSNP
rs1044976350 479 dbSNP
rs1444763544 485 dbSNP
rs571703965 488 dbSNP
rs917665677 493 dbSNP
rs1478973784 495 dbSNP
rs1034902321 496 dbSNP
rs993831999 497 dbSNP
rs1321443665 512 dbSNP
rs974013121 516 dbSNP
rs376528343 517 dbSNP
rs1317733229 519 dbSNP
rs1332124313 528 dbSNP
rs962958999 528 dbSNP
rs911032378 531 dbSNP
rs1323249376 537 dbSNP
rs1016666056 541 dbSNP
rs768432527 553 dbSNP
rs1229457543 560 dbSNP
rs1262117661 569 dbSNP
rs1431375088 571 dbSNP
rs1203973966 572 dbSNP
rs231522 573 dbSNP
rs955478619 578 dbSNP
rs1268157848 585 dbSNP
rs1169421431 588 dbSNP
rs1472593843 594 dbSNP
rs1366734012 596 dbSNP
rs1273397247 602 dbSNP
rs1030200810 603 dbSNP
rs779899677 608 dbSNP
rs544761588 621 dbSNP
rs1443117062 623 dbSNP
rs1250408161 624 dbSNP
rs1028921731 626 dbSNP
rs1406896533 627 dbSNP
rs956070180 628 dbSNP
rs998330162 630 dbSNP
rs577682602 631 dbSNP
rs1333570531 642 dbSNP
rs1237912162 645 dbSNP
rs112709856 648 dbSNP
rs140575754 649 dbSNP
rs769402001 652 dbSNP
rs116450361 658 dbSNP
rs1178667150 669 dbSNP
rs1285656757 671 dbSNP
rs1349780487 672 dbSNP
rs1014870886 679 dbSNP
rs373435659 680 dbSNP
rs538433633 681 dbSNP
rs530336162 685 dbSNP
rs752945099 696 dbSNP
rs1161753593 699 dbSNP
rs1365436884 700 dbSNP
rs1430975164 702 dbSNP
rs1300218591 703 dbSNP
rs896794391 704 dbSNP
rs1411617435 707 dbSNP
rs1370866733 709 dbSNP
rs1038058652 711 dbSNP
rs1384631184 713 dbSNP
rs1302322153 715 dbSNP
rs1403463568 716 dbSNP
rs941246727 719 dbSNP
rs1301234332 727 dbSNP
rs779355901 731 dbSNP
rs528479686 732 dbSNP
rs1200890001 737 dbSNP
rs1243904874 739 dbSNP
rs1473140298 743 dbSNP
rs985310668 752 dbSNP
rs567914846 756 dbSNP
rs1181777039 757 dbSNP
rs991065184 761 dbSNP
rs939193901 764 dbSNP
rs1173139534 768 dbSNP
rs1353332762 773 dbSNP
rs933843200 774 dbSNP
rs556084084 778 dbSNP
rs374094632 781 dbSNP
rs1450043736 785 dbSNP
rs961049983 790 dbSNP
rs1365252410 799 dbSNP
rs1032935733 802 dbSNP
rs1016572568 804 dbSNP
rs534528264 805 dbSNP
rs11544389 814 dbSNP
rs1210083670 817 dbSNP
rs1349283333 820 dbSNP
rs74344201 821 dbSNP
rs998795710 828 dbSNP
rs1462790252 831 dbSNP
rs1201970686 833 dbSNP
rs533240359 834 dbSNP
rs1230091101 838 dbSNP
rs1486230006 840 dbSNP
rs901327424 847 dbSNP
rs1188429475 849 dbSNP
rs1031952101 859 dbSNP
rs1282606535 871 dbSNP
rs556314965 878 dbSNP
rs866901706 891 dbSNP
rs1468607834 912 dbSNP
rs771970443 918 dbSNP
rs1434002863 921 dbSNP
rs1332633302 923 dbSNP
rs1345488331 926 dbSNP
rs904750384 927 dbSNP
rs1286623919 942 dbSNP
rs1361123812 956 dbSNP
rs1387310665 962 dbSNP
rs1285154436 965 dbSNP
rs1321119619 969 dbSNP
rs766854244 977 dbSNP
rs539268042 980 dbSNP
rs569339066 987 dbSNP
rs1262750972 988 dbSNP
rs1317751572 994 dbSNP
rs549670012 994 dbSNP
rs760741486 1015 dbSNP
rs948712629 1016 dbSNP
rs894589309 1029 dbSNP
rs1271745969 1030 dbSNP
rs1057207370 1032 dbSNP
rs531395755 1044 dbSNP
rs868459113 1045 dbSNP
rs560793528 1047 dbSNP
rs1344059168 1048 dbSNP
rs1413295833 1053 dbSNP
rs1304860060 1054 dbSNP
rs1172553085 1059 dbSNP
rs1343640772 1060 dbSNP
rs972516120 1062 dbSNP
rs542491635 1067 dbSNP
rs1248849796 1069 dbSNP
rs1038035966 1072 dbSNP
rs939953073 1082 dbSNP
rs527614515 1083 dbSNP
rs559860510 1086 dbSNP
rs1245875058 1092 dbSNP
rs909769662 1094 dbSNP
rs941064901 1106 dbSNP
rs1210022828 1107 dbSNP
rs1294501934 1112 dbSNP
rs1490006152 1113 dbSNP
rs983753525 1118 dbSNP
rs1329302315 1120 dbSNP
rs1233844656 1127 dbSNP
rs1471382609 1129 dbSNP
rs72628311 1129 dbSNP
rs1406864079 1130 dbSNP
rs1262380405 1131 dbSNP
rs750508776 1132 dbSNP
rs3080356 1133 dbSNP
rs67353312 1133 dbSNP
rs745840862 1133 dbSNP
rs747041144 1133 dbSNP
rs1423959239 1134 dbSNP
rs953730687 1134 dbSNP
rs1028520396 1135 dbSNP
rs1329254036 1135 dbSNP
rs976511994 1136 dbSNP
rs965478439 1137 dbSNP
rs1246729835 1138 dbSNP
rs530084948 1138 dbSNP
rs1031858765 1139 dbSNP
rs988607691 1139 dbSNP
rs1429834592 1140 dbSNP
rs1439902332 1142 dbSNP
rs934712594 1142 dbSNP
rs1364721813 1144 dbSNP
rs1318837027 1146 dbSNP
rs112934026 1147 dbSNP
rs1444881499 1147 dbSNP
rs1382888722 1149 dbSNP
rs374356882 1150 dbSNP
rs1168406239 1151 dbSNP
rs1399772075 1151 dbSNP
rs189977834 1151 dbSNP
rs1244225078 1154 dbSNP
rs1338985439 1154 dbSNP
rs1440037894 1154 dbSNP
rs1389501948 1155 dbSNP
rs79782040 1156 dbSNP
rs1021884194 1157 dbSNP
rs1413272581 1159 dbSNP
rs1427632000 1162 dbSNP
rs1173513284 1163 dbSNP
rs1205140574 1163 dbSNP
rs1240942550 1164 dbSNP
rs112263548 1169 dbSNP
rs1193363070 1169 dbSNP
rs1243717170 1169 dbSNP
rs140654052 1169 dbSNP
rs541472497 1169 dbSNP
rs559488913 1169 dbSNP
rs993458036 1169 dbSNP
rs1324690251 1171 dbSNP
rs231523 1177 dbSNP
rs1387912642 1181 dbSNP
rs894461168 1184 dbSNP
rs1260863201 1187 dbSNP
rs1190134786 1188 dbSNP
rs1464922339 1193 dbSNP
rs1236387883 1202 dbSNP
rs1207859822 1206 dbSNP
rs1444049705 1216 dbSNP
rs1026444659 1220 dbSNP
rs762047790 1225 dbSNP
rs1227350139 1232 dbSNP
rs1339867637 1234 dbSNP
rs1192823279 1236 dbSNP
rs961116315 1237 dbSNP
rs1197016440 1238 dbSNP
rs1017119716 1239 dbSNP
rs1002975851 1245 dbSNP
rs1005208234 1246 dbSNP
rs184164849 1248 dbSNP
rs1049424285 1249 dbSNP
rs1399077828 1255 dbSNP
rs1365938842 1262 dbSNP
rs1302351248 1268 dbSNP
rs1407077398 1276 dbSNP
rs34736389 1280 dbSNP
rs998471587 1291 dbSNP
rs1239276808 1307 dbSNP
rs897884266 1311 dbSNP
rs574264435 1314 dbSNP
rs773981039 1315 dbSNP
rs1052876537 1316 dbSNP
rs1429459226 1319 dbSNP
rs1490823321 1324 dbSNP
rs1369129681 1327 dbSNP
rs895895487 1328 dbSNP
rs1266449652 1329 dbSNP
rs1170021025 1330 dbSNP
rs934533495 1332 dbSNP
rs1053227174 1335 dbSNP
rs939817592 1343 dbSNP
rs926020129 1345 dbSNP
rs1365824953 1346 dbSNP
rs1449709848 1347 dbSNP
rs556032806 1349 dbSNP
rs948844313 1351 dbSNP
rs1366680162 1352 dbSNP
rs1179600458 1354 dbSNP
rs1019886813 1355 dbSNP
rs1048294793 1355 dbSNP
rs1390436142 1367 dbSNP
rs1237966548 1370 dbSNP
rs932333334 1372 dbSNP
rs920958825 1374 dbSNP
rs768471069 1383 dbSNP
rs1392389869 1389 dbSNP
rs762702112 1411 dbSNP
rs960242584 1416 dbSNP
rs919550263 1420 dbSNP
rs1204381335 1425 dbSNP
rs1315171345 1426 dbSNP
rs1361457166 1428 dbSNP
rs1481929374 1431 dbSNP
rs976797588 1431 dbSNP
rs1276519900 1433 dbSNP
rs965167243 1442 dbSNP
rs1207491920 1443 dbSNP
rs972209355 1444 dbSNP
rs1480829607 1448 dbSNP
rs1197406000 1452 dbSNP
rs771015535 1458 dbSNP
rs534462180 1462 dbSNP
rs1016447454 1463 dbSNP
rs567196143 1468 dbSNP
rs1446572375 1469 dbSNP
rs1005690305 1474 dbSNP
rs557819967 1475 dbSNP
rs924320419 1476 dbSNP
rs1312363645 1484 dbSNP
rs1462752486 1491 dbSNP
rs557215610 1495 dbSNP
rs968863901 1499 dbSNP
rs376793047 1506 dbSNP
rs1285259139 1513 dbSNP
rs1409751829 1516 dbSNP
rs569197744 1516 dbSNP
rs1369035600 1522 dbSNP
rs1028374729 1528 dbSNP
rs1243220753 1540 dbSNP
rs1013148444 1554 dbSNP
rs959187253 1559 dbSNP
rs1430869396 1563 dbSNP
rs2543098 1567 dbSNP
rs1035707775 1577 dbSNP
rs1348903283 1580 dbSNP
rs1249433984 1586 dbSNP
rs901094138 1588 dbSNP
rs1198224052 1591 dbSNP
rs1003250889 1593 dbSNP
rs998632417 1610 dbSNP
rs139058804 1611 dbSNP
rs191368005 1616 dbSNP
rs1172939638 1621 dbSNP
rs567106467 1621 dbSNP
rs1421901132 1630 dbSNP
rs1465481962 1635 dbSNP
rs146672113 1639 dbSNP
rs1407930631 1640 dbSNP
rs1036402643 1642 dbSNP
rs1449749943 1643 dbSNP
rs187547283 1646 dbSNP
rs1362515315 1647 dbSNP
rs1413932178 1655 dbSNP
rs1004031957 1665 dbSNP
rs1057439218 1666 dbSNP
rs1223961100 1667 dbSNP
rs938689699 1668 dbSNP
rs1325940123 1669 dbSNP
rs142076578 1671 dbSNP
rs1255518477 1678 dbSNP
rs1486259536 1683 dbSNP
rs1188782144 1684 dbSNP
rs972282727 1692 dbSNP
rs1477699211 1696 dbSNP
rs963645209 1700 dbSNP
rs1048681430 1706 dbSNP
rs932598739 1707 dbSNP
rs1430902366 1709 dbSNP
rs1412424224 1710 dbSNP
rs1174961625 1712 dbSNP
rs59625378 1725 dbSNP
rs1040719485 1730 dbSNP
rs1488058826 1731 dbSNP
rs986324068 1735 dbSNP
rs943684685 1736 dbSNP
rs1284979760 1748 dbSNP
rs374083746 1751 dbSNP
rs1323507530 1752 dbSNP
rs1218127311 1754 dbSNP
rs1284419770 1756 dbSNP
rs1273902452 1757 dbSNP
rs1227924722 1760 dbSNP
rs1223623278 1764 dbSNP
rs1349168061 1767 dbSNP
rs977154093 1776 dbSNP
rs1290792442 1778 dbSNP
rs1408348475 1784 dbSNP
rs968895791 1787 dbSNP
rs914760613 1792 dbSNP
rs1392305035 1797 dbSNP
rs1367378907 1798 dbSNP
rs1359763298 1809 dbSNP
rs992036282 1813 dbSNP
rs1425253391 1827 dbSNP
rs1304919067 1829 dbSNP
rs367676406 1835 dbSNP
rs1347882732 1840 dbSNP
rs958993759 1846 dbSNP
rs1036311744 1847 dbSNP
rs72836572 1848 dbSNP
rs962010528 1849 dbSNP
rs562390050 1850 dbSNP
rs1242335182 1851 dbSNP
rs544310902 1853 dbSNP
rs887834526 1860 dbSNP
rs573798337 1872 dbSNP
rs1294658644 1876 dbSNP
rs9902075 1880 dbSNP
rs78920541 1887 dbSNP
rs746704665 1889 dbSNP
rs9896181 1892 dbSNP
rs548221328 1896 dbSNP
rs902830319 1897 dbSNP
rs754223674 1898 dbSNP
rs1041379204 1901 dbSNP
rs1036366558 1902 dbSNP
rs558419665 1908 dbSNP
rs1355285883 1909 dbSNP
rs1208149210 1911 dbSNP
rs780473057 1912 dbSNP
rs756628263 1913 dbSNP
rs932191361 1916 dbSNP
rs116197501 1918 dbSNP
rs1228054230 1919 dbSNP
rs750456154 1922 dbSNP
rs183268384 1923 dbSNP
rs1311911718 1932 dbSNP
rs991674408 1938 dbSNP
rs1388950288 1939 dbSNP
rs767618952 1940 dbSNP
rs1371275600 1942 dbSNP
rs757324934 1943 dbSNP
rs1235607755 1944 dbSNP
rs1472441744 1945 dbSNP
rs1168246046 1946 dbSNP
rs764779730 1947 dbSNP
rs925965273 1948 dbSNP
rs1432237031 1950 dbSNP
rs981642395 1951 dbSNP
rs1399838604 1960 dbSNP
rs969030325 1960 dbSNP
rs751787496 1961 dbSNP
rs231524 1963 dbSNP
rs1013153682 1966 dbSNP
rs894281542 1967 dbSNP
rs1014892992 1969 dbSNP
rs1271333356 1970 dbSNP
rs1035543198 1972 dbSNP
rs73985803 1973 dbSNP
rs897920643 1974 dbSNP
rs952134916 1975 dbSNP
rs1193785657 1976 dbSNP
rs1395892364 1980 dbSNP
rs192651655 1982 dbSNP
rs996729193 1983 dbSNP
rs942083642 1990 dbSNP
rs188358717 1991 dbSNP
rs1174574882 1992 dbSNP
rs899652961 1994 dbSNP
rs562849127 1996 dbSNP
rs1050728334 1997 dbSNP
rs1019549640 1999 dbSNP
rs1398479001 2000 dbSNP
rs1277990140 2001 dbSNP
rs1483203093 2002 dbSNP
rs548718388 2008 dbSNP
rs77504473 2013 dbSNP
rs1235847838 2014 dbSNP
rs976223752 2017 dbSNP
rs1287998357 2020 dbSNP
rs1041409879 2021 dbSNP
rs1215573947 2026 dbSNP
rs775149359 2030 dbSNP
rs946995561 2034 dbSNP
rs892925504 2036 dbSNP
rs765206581 2037 dbSNP
rs1296355978 2041 dbSNP
rs1225732744 2042 dbSNP
rs1366670032 2045 dbSNP
rs1376207263 2049 dbSNP
rs1055943773 2050 dbSNP
rs977053050 2060 dbSNP
rs763636923 2062 dbSNP
rs1418445587 2063 dbSNP
rs370979078 2063 dbSNP
rs937553528 2065 dbSNP
rs914237043 2074 dbSNP
rs759566780 2075 dbSNP
rs958877861 2079 dbSNP
rs981547258 2081 dbSNP
rs1035488744 2084 dbSNP
rs940955001 2093 dbSNP
rs115563871 2095 dbSNP
rs550862089 2096 dbSNP
rs1447907486 2099 dbSNP
rs1207849128 2103 dbSNP
rs1006620680 2104 dbSNP
rs952135826 2106 dbSNP
rs1179293163 2109 dbSNP
rs887755398 2112 dbSNP
rs1050874932 2117 dbSNP
rs922072101 2119 dbSNP
rs996404832 2120 dbSNP
rs752453608 2122 dbSNP
rs1040510566 2123 dbSNP
rs141983039 2126 dbSNP
rs924344542 2126 dbSNP
rs551648430 2128 dbSNP
rs1333009210 2129 dbSNP
rs1373995284 2131 dbSNP
rs1250704954 2133 dbSNP
rs1041439903 2134 dbSNP
rs776240134 2137 dbSNP
rs966129168 2139 dbSNP
rs9901061 2141 dbSNP
rs1423363650 2142 dbSNP
rs1339882610 2145 dbSNP
rs1254661564 2147 dbSNP
rs991573393 2152 dbSNP
rs1008028880 2154 dbSNP
rs1178112060 2163 dbSNP
rs1426104210 2164 dbSNP
rs958641716 2165 dbSNP
rs139690624 2168 dbSNP
rs377620530 2168 dbSNP
rs1466521781 2169 dbSNP
rs1274386693 2177 dbSNP
rs1397676987 2179 dbSNP
rs1203521813 2180 dbSNP
rs1343849885 2182 dbSNP
rs1381205672 2183 dbSNP
rs1394185333 2184 dbSNP
rs967289567 2188 dbSNP
rs1270447539 2189 dbSNP
rs981254948 2190 dbSNP
rs961902211 2191 dbSNP
rs1243402763 2192 dbSNP
rs1260168889 2194 dbSNP
rs1338211286 2194 dbSNP
rs1316317388 2197 dbSNP
rs1198042521 2204 dbSNP
rs1314722470 2205 dbSNP
rs543597565 2211 dbSNP
rs1020209973 2214 dbSNP
rs1180610063 2218 dbSNP
rs1011280774 2231 dbSNP
rs1196317162 2234 dbSNP
rs892781119 2235 dbSNP
rs1477309382 2236 dbSNP
rs150651460 2243 dbSNP
rs375767708 2243 dbSNP
rs1398872167 2246 dbSNP
rs1055441651 2248 dbSNP
rs1302191121 2250 dbSNP
rs1001705196 2255 dbSNP
rs1366829386 2256 dbSNP
rs1276104247 2261 dbSNP
rs1339634925 2262 dbSNP
rs906917646 2272 dbSNP
rs1045879933 2273 dbSNP
rs940861290 2279 dbSNP
rs1475813105 2283 dbSNP
rs908169892 2285 dbSNP
rs762929828 2297 dbSNP
rs1251812087 2300 dbSNP
rs1488917390 2303 dbSNP
rs746558427 2315 dbSNP
rs947125520 2318 dbSNP
rs529125731 2323 dbSNP
rs1232195951 2326 dbSNP
rs1488197122 2333 dbSNP
rs914340155 2337 dbSNP
rs1430887423 2338 dbSNP
rs930686674 2341 dbSNP
rs937014937 2350 dbSNP
rs562472798 2353 dbSNP
rs940607001 2354 dbSNP
rs974741325 2355 dbSNP
rs77319852 2359 dbSNP
rs1286427937 2360 dbSNP
rs528953306 2362 dbSNP
rs1300718715 2364 dbSNP
rs1354552945 2367 dbSNP
rs2537 2368 dbSNP
rs974751288 2373 dbSNP
rs966044849 2377 dbSNP
rs967194857 2378 dbSNP
rs1386430062 2385 dbSNP
rs1222781313 2392 dbSNP
rs1018921356 2403 dbSNP
rs1487317265 2404 dbSNP
rs1020241132 2407 dbSNP
rs1167186980 2414 dbSNP
rs1011890078 2419 dbSNP
rs1441060935 2420 dbSNP
rs1462067848 2422 dbSNP
rs999695000 2427 dbSNP
rs902783556 2429 dbSNP
rs957282162 2435 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000377184.3 | 3UTR | GCACGUGCGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000377184.3 | 3UTR | ACGUGCGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000377184.3 | 3UTR | ACGUGCGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000377184.3 | 3UTR | GCACGUGCGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000377184.3 | 3UTR | GCACGUGCGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000377184.3 | 3UTR | ACGUGCGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000377184.3 | 3UTR | GCACGUGCGUGUGUGUGUGUGUGUGUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000377184.3 | 3UTR | GCACGUGCGUGUGUGUGUGUGUGUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000377184.3 | 3UTR | GCACGUGCGUGUGUGUGUGUGUGUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-6767-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066671 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 4
MIRT442663 GLRA2 glycine receptor alpha 2 2 2
MIRT457038 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT487824 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT500161 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT505924 RCAN3 RCAN family member 3 2 4
MIRT529861 GPR173 G protein-coupled receptor 173 2 2
MIRT569240 SUSD1 sushi domain containing 1 2 2
MIRT575091 Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 2 5
MIRT575972 Slfn5 schlafen 5 2 3
MIRT606881 SLC1A5 solute carrier family 1 member 5 2 7
MIRT607097 SLFN5 schlafen family member 5 2 3
MIRT607990 NSUN3 NOP2/Sun RNA methyltransferase family member 3 2 6
MIRT608479 RRP36 ribosomal RNA processing 36 2 2
MIRT610984 GNA14 G protein subunit alpha 14 2 2
MIRT612308 WDR37 WD repeat domain 37 2 4
MIRT612777 MATN1 matrilin 1, cartilage matrix protein 2 4
MIRT615030 DNAL1 dynein axonemal light chain 1 2 2
MIRT615500 MPP2 membrane palmitoylated protein 2 2 2
MIRT618026 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT618763 HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2 2
MIRT621458 STX1B syntaxin 1B 2 2
MIRT622221 SLC36A1 solute carrier family 36 member 1 2 2
MIRT628784 TMEM154 transmembrane protein 154 2 2
MIRT632385 SNAPC3 small nuclear RNA activating complex polypeptide 3 2 2
MIRT652751 TFAM transcription factor A, mitochondrial 2 2
MIRT661806 NUP85 nucleoporin 85 2 2
MIRT663148 RD3 retinal degeneration 3 2 2
MIRT663867 MUC20 mucin 20, cell surface associated 2 2
MIRT664448 CCDC108 cilia and flagella associated protein 65 2 2
MIRT669932 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT670303 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT672171 FAM174B family with sequence similarity 174 member B 2 2
MIRT672280 SHE Src homology 2 domain containing E 2 2
MIRT678057 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT679781 GOLGA2 golgin A2 2 2
MIRT683451 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT684218 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT690932 RAD51 RAD51 recombinase 2 2
MIRT692944 EXOSC2 exosome component 2 2 2
MIRT700401 RAB13 RAB13, member RAS oncogene family 2 2
MIRT724462 PRKX protein kinase, X-linked 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6767 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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