pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol C6   
Synonyms -
Description complement C6
Transcript NM_000065   
Other Transcripts NM_001115131   
Expression
Putative miRNA Targets on C6
3'UTR of C6
(miRNA target sites are highlighted)
>C6|NM_000065|3'UTR
   1 CACAATTACTGCTAGGCCCAGCACAATGAACAGATTTACCATCCCGAAGAACCAACTCCTACAAATGAGAATTCTTGCAC
  81 AAACAGCAGACTGGCATGCTCAAAGTTACTGACAAAAATTATTTTCTGTTAGTTTGAGATCATTATTCTCCCCTGACTCT
 161 CCTGTTTGGGCATGTCTTATTCAGTTCCAGCTCATGACGCCCTGTAGCATACCCCTAGGTACCAACTTCCACAGCAGTCT
 241 CGTAAATTCTCCTGTTCACATTGTACAAAAATAATGTGACTTCTGAGGCCCTTATGTAGCCTGTGACATTAAGCATTCTC
 321 GCAATTAGAAATAAGAATAAAACCCATAATTTTCTTCAATGAGTTAATAAACAGAAATCTCCAGAACCTCTGAAACACAT
 401 TCTTGAAGCCCAGCTTTCATATCTTCATTCAACAAATAATTTCTGAGTGTGTATACAGGATGTCAAGTACTGACCAAAGT
 481 CCTGAGAACTCGGCAGATAATAAAACAGACAAAAGCCTTTGCCTTCATGAAGCATACATTCATTCAGGGGTAGACACACA
 561 AAAAATGAAATAAACAGGTAAAATATGTAGCATGTTTGATGGTGATAATTGTTTTGGAGAAAATACAACACGGAAGGGTG
 641 AGTCCCATCCTTAATTATCATCTTATGCAAGGAAATATT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucgACAAGGACGACUu 5'
             |||  || |||| 
Target 5' taaTGTGACTTCTGAg 3'
272 - 287 117.00 -8.80
2
miRNA  3' ucgacAAGGACGAcuu 5'
               || |||||   
Target 5' cacaaTTACTGCTagg 3'
1 - 16 107.00 -6.60
3
miRNA  3' ucgacaAGGACGACUu 5'
                |||||:| | 
Target 5' aaattcTCCTGTTCAc 3'
244 - 259 102.00 -6.13
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30462109 28 COSMIC
COSN31598588 33 COSMIC
COSN30117402 34 COSMIC
COSN31517319 49 COSMIC
COSN26968752 51 COSMIC
COSN31536457 55 COSMIC
COSN30167393 74 COSMIC
COSN31598445 77 COSMIC
COSN31496871 92 COSMIC
COSN31496868 93 COSMIC
COSN20043902 94 COSMIC
COSN30489511 120 COSMIC
COSN30490001 151 COSMIC
COSN6297255 457 COSMIC
COSN2106134 491 COSMIC
COSN8225229 572 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753213847 1 dbSNP
rs765534691 3 dbSNP
rs759921719 5 dbSNP
rs777016927 8 dbSNP
rs1229878464 10 dbSNP
rs1350768543 11 dbSNP
rs771049005 13 dbSNP
rs761028442 15 dbSNP
rs773101647 18 dbSNP
rs781217796 26 dbSNP
rs561825399 27 dbSNP
rs200177908 28 dbSNP
rs1375739032 31 dbSNP
rs774461107 33 dbSNP
rs575085526 36 dbSNP
rs375585959 39 dbSNP
rs749068773 43 dbSNP
rs779956309 45 dbSNP
rs755714988 46 dbSNP
rs745537327 49 dbSNP
rs753449005 49 dbSNP
rs1281394230 58 dbSNP
rs1374908031 60 dbSNP
rs1455563767 61 dbSNP
rs1027030342 64 dbSNP
rs1239637532 71 dbSNP
rs980847010 76 dbSNP
rs183922427 81 dbSNP
rs545189174 87 dbSNP
rs1803227 89 dbSNP
rs1209268381 90 dbSNP
rs969470414 95 dbSNP
rs1025109624 96 dbSNP
rs1014188168 97 dbSNP
rs892687690 104 dbSNP
rs1438563104 105 dbSNP
rs1031655789 106 dbSNP
rs1001147874 109 dbSNP
rs903526047 110 dbSNP
rs1050084418 111 dbSNP
rs1452335380 113 dbSNP
rs577817297 119 dbSNP
rs901620777 121 dbSNP
rs1243561476 124 dbSNP
rs1326802221 128 dbSNP
rs1040155561 129 dbSNP
rs1054225600 130 dbSNP
rs553245399 145 dbSNP
rs1207598434 148 dbSNP
rs940506242 158 dbSNP
rs907725182 160 dbSNP
rs144139847 172 dbSNP
rs751348836 187 dbSNP
rs534297030 188 dbSNP
rs1235814530 190 dbSNP
rs14169 196 dbSNP
rs767113481 198 dbSNP
rs73750290 199 dbSNP
rs555488091 212 dbSNP
rs955513262 215 dbSNP
rs1213844427 216 dbSNP
rs922444529 217 dbSNP
rs969436040 218 dbSNP
rs1025075164 224 dbSNP
rs1197860415 225 dbSNP
rs1373389853 239 dbSNP
rs992283347 241 dbSNP
rs1423415 242 dbSNP
rs1465160833 249 dbSNP
rs570260298 251 dbSNP
rs772974738 260 dbSNP
rs756733060 261 dbSNP
rs1443051585 264 dbSNP
rs1323167999 271 dbSNP
rs952037576 275 dbSNP
rs1034351928 280 dbSNP
rs1001516967 285 dbSNP
rs1313609899 290 dbSNP
rs1317894582 291 dbSNP
rs551637633 294 dbSNP
rs1423416 295 dbSNP
rs1487235335 296 dbSNP
rs1208814927 307 dbSNP
rs776821708 312 dbSNP
rs1262001421 313 dbSNP
rs1045994554 319 dbSNP
rs1169658883 320 dbSNP
rs9200 321 dbSNP
rs901547232 329 dbSNP
rs1421459254 331 dbSNP
rs1054173341 335 dbSNP
rs1040510228 336 dbSNP
rs548097850 339 dbSNP
rs1162817554 340 dbSNP
rs529234037 343 dbSNP
rs10067242 354 dbSNP
rs1296785297 355 dbSNP
rs1340413867 356 dbSNP
rs1415891579 361 dbSNP
rs1295675638 363 dbSNP
rs933913165 376 dbSNP
rs1243521354 381 dbSNP
rs531036526 387 dbSNP
rs1260938166 388 dbSNP
rs780430648 392 dbSNP
rs1214138636 401 dbSNP
rs1262154928 409 dbSNP
rs549858178 421 dbSNP
rs1189910006 422 dbSNP
rs1422127515 430 dbSNP
rs927215528 431 dbSNP
rs563497043 434 dbSNP
rs1204457879 438 dbSNP
rs1364578296 443 dbSNP
rs972675816 448 dbSNP
rs1157110727 449 dbSNP
rs1360231731 453 dbSNP
rs531644988 457 dbSNP
rs1308586957 458 dbSNP
rs1315352031 459 dbSNP
rs1377708340 462 dbSNP
rs1394928972 463 dbSNP
rs1307137570 466 dbSNP
rs1337050452 472 dbSNP
rs961159277 473 dbSNP
rs1284885180 474 dbSNP
rs776929039 479 dbSNP
rs564613317 491 dbSNP
rs984836772 506 dbSNP
rs952154304 511 dbSNP
rs1355165826 512 dbSNP
rs1034340933 516 dbSNP
rs1294167651 517 dbSNP
rs1416780179 523 dbSNP
rs948020061 534 dbSNP
rs191402179 536 dbSNP
rs1454974656 538 dbSNP
rs1368801714 541 dbSNP
rs376366014 544 dbSNP
rs1357901954 547 dbSNP
rs1465945297 550 dbSNP
rs73750288 576 dbSNP
rs1397940550 577 dbSNP
rs1356178529 590 dbSNP
rs1162492188 593 dbSNP
rs1371352175 597 dbSNP
rs1236192322 600 dbSNP
rs1298974510 602 dbSNP
rs1474772427 610 dbSNP
rs1311418807 620 dbSNP
rs1418257173 629 dbSNP
rs1010496635 631 dbSNP
rs543192104 632 dbSNP
rs1196895079 633 dbSNP
rs1033219348 636 dbSNP
rs73750287 637 dbSNP
rs1193176707 638 dbSNP
rs1177242057 642 dbSNP
rs1423441883 649 dbSNP
rs762649576 650 dbSNP
rs150777213 658 dbSNP
rs1171654955 659 dbSNP
rs761207427 662 dbSNP
rs1049508794 671 dbSNP
rs1426493162 683 dbSNP
rs968243724 693 dbSNP
rs1029188759 694 dbSNP
rs996408625 695 dbSNP
rs184933625 696 dbSNP
rs537049045 697 dbSNP
rs1334612559 698 dbSNP
rs1291448260 700 dbSNP
rs1366567211 706 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000337836.5 | 3UTR | AGGAGGAGGAGGAGGAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000337836.5 | 3UTR | UGAGGAGGAGGAGGAGGAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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