pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ADRA2B   
Synonyms ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
Description adrenoceptor alpha 2B
Transcript NM_000682   
Expression
Putative miRNA Targets on ADRA2B
3'UTR of ADRA2B
(miRNA target sites are highlighted)
>ADRA2B|NM_000682|3'UTR
   1 GCCCGCCTGCGCTGCCCCTGTGGGGTTGGTGCGGTGGCGCCGGGGTCACCCTGCTTCTTGCCCTGCTGTGTGTGGCTGCC
  81 TCCCCTGGGCTTTCTGCTCCCTGCCCAGATCCTGTAGGCCTCATCTTAGGAACCCCTTGGGAGGGGTGGGCAGGGGGGCT
 161 GCTAGCAAGGGTCCCAGTGAAGCTTCCCCTTGCCGGCTTAGCTGTGGGGGACCCCTTCTCCACCCTCTCCCTGAGCACAG
 241 GCCGATGGAGGTGGTTCAAATCCTCTGGAACATAGCCAAGACCAGGAGAAGAGAGAGCACTTTCTTCCCAGAGCCCCATG
 321 CTCTCCAGACCAATGTCTGGGCTTCCCTTTCTTGAGGACCTTGTGTTCCTGGCAGGTCACTTGCTTGTGGTGTTTTCGTT
 401 TCTTTTTCATCTCCCCCCCACCCACAAAGAGCACGGAGCCAGCCTTCCACTTTTCCCAGTGGGGCCTGCTGCTGAGGGGG
 481 AGGAAGAAACGAAGACTGATCACCCACGCTAGGCACTCGCGGTCCCTGGCAGGCGCTGGGATGGGGGCTTATGGGGTGGC
 561 ATCGTCTCTGGGCCCTCCTTTCCCCCTTTGCCTGTTTTCGGATCTGTGGTTCCTTTGAAAGCCAGAACAATGGATCGGCT
 641 TCCTTACCCAGCACCCCTCCGGTAGGTGGGTGGCCACGTGGATGCCTCGCTGGGGCGGTCTTGGAGGCCTGGTCTCTGCC
 721 TCGACGGGAGATCCCCGATCACTGGCATTCACCCCCTGCAAAAATCGGGGCGACAATAGCTCACTGCCTACTTGCTGCAG
 801 GGAGATGAAAGGCTTTGCAGAAAGCTTTGAGCTCTGTGGGGGAACACACTAGAGAACCAAAAATGTGATTATATGGTGAT
 881 ATAAAAATCCCTTTCCTCTGTGTTTACCACCACCTGTCTTCCTGTAGACTTTTGTTCTGTCCCTGGGGTGTGTGAATTCC
 961 TACCCCGAACTGGAAGCCGGGAGTGGCAGACAGAATCACTATTTCAAGTTAAAGGATCTCTTTGAGAATGTGTTCTTCTG
1041 GCTGCAAAGGTCTGAGTTATTACGCTACATGACAACGTTTCGACATTTCACCGGCAACACCAAGAGGGTTTTTAGTGGCT
1121 TGGGTCTCCCCAGTGGGGGATAAGTCTTTTGTCATCAAGGAGGCAAATTGTCTCCCCAAGACAGCTCAAAATATCCACAC
1201 CTCGGCAACAGTCTAAGATGAGAGCCTGTGACAGGTGGCAGCGCCCCCAGGTGGGGTACTGGCATCAGAGCCTGGTGCGC
1281 CCCTAGGGGAGCCTCCCACTGGAGTGCCCGGCCAGGTCTCCAAGCCCCAAATGAGTCCTTGTGAACCACAACTGATCCCC
1361 CCAGGTGGGTGCTTGTGGACTGCCTCGGACCCAGCCACGCTGCTCCCCGCAATGCTGATGGGGCTGTGCATTGAGGACCC
1441 CTGCTTCCTGGTTCTCAGTCCCACCCCAAAACCTGGCACCCAGAACAGTTGGAAGTGTGGAAAGGAGGTTTATCGGCCTT
1521 CCCTTGGAGAGGGCCTGGCTTCAACATTGGGCCAGTAGGCATCTTAGCTTGGCAGGTGTCGGGGGAATGGGCCAGATGGA
1601 CCTGCTAGATTTGGAAGGGCACCGAGGGAGTTTTCTGGGTGTAGAGAGAATGGAGGGGACCAAAAAGAGTCCTTCCTGGG
1681 GTGTGGGAGGCTTCCCAGCTTGGTCCTCAGTGGGTTGTTGAGGCCAGAGTATCGCCCTGGGATGTGGTGGGGAGCTGGGC
1761 CAGGAGAGGGACTGACTGTGACCCTCTGCTGGCCGGTCTTGTGTGCGCCCCATGGGACCCCCAGTGTTCTTGCCTGTGAC
1841 CTCTTATTGCGACATGCAGGTGGTGTTTTTTTTTTTTTTAAACTCTGAGCTATTTTATCAATAAAGGATATTTTGTAATA
1921 AG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucGACAAGGACGACUu 5'
            |||   ||||||| 
Target 5' gcCTG---CTGCTGAg 3'
464 - 476 143.00 -11.90
2
miRNA  3' ucGACAA--GGACGACuu 5'
            :| ||  |||||||  
Target 5' gcTTCTTGCCCTGCTGtg 3'
53 - 70 128.00 -11.50
3
miRNA  3' ucGACA----AGGACGACUu 5'
            ||||     :||||||: 
Target 5' gaCTGTGACCCTCTGCTGGc 3'
1774 - 1793 128.00 -13.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14014091 4 COSMIC
COSN26965300 5 COSMIC
COSN28870996 10 COSMIC
COSN30497486 36 COSMIC
COSN30183396 39 COSMIC
COSN30132870 58 COSMIC
COSN25117604 559 COSMIC
COSN31533446 677 COSMIC
COSN20264592 678 COSMIC
COSN28813930 697 COSMIC
COSN31594009 723 COSMIC
COSN22766537 725 COSMIC
COSN20090594 733 COSMIC
COSN30540307 766 COSMIC
COSN31538657 771 COSMIC
COSN31527473 772 COSMIC
COSN28770186 850 COSMIC
COSN31543900 863 COSMIC
COSN31518346 864 COSMIC
COSN30170927 895 COSMIC
COSN21772980 933 COSMIC
COSN31539771 991 COSMIC
COSN26496125 1025 COSMIC
COSN29455604 1082 COSMIC
COSN1862873 1268 COSMIC
COSN6559674 1287 COSMIC
COSN17181444 1301 COSMIC
COSN28409022 1733 COSMIC
COSN6559673 1807 COSMIC
COSN7996021 1851 COSMIC
COSN20096968 1865 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs186085130 2 dbSNP
rs766575378 4 dbSNP
rs34894270 5 dbSNP
rs1283553335 9 dbSNP
rs528195928 10 dbSNP
rs749269879 11 dbSNP
rs1297637620 18 dbSNP
rs1382769067 19 dbSNP
rs1262727139 20 dbSNP
rs1383948248 20 dbSNP
rs1286857033 23 dbSNP
rs775092649 24 dbSNP
rs769442805 29 dbSNP
rs75133239 32 dbSNP
rs770552082 33 dbSNP
rs372042632 38 dbSNP
rs368428483 39 dbSNP
rs35355631 41 dbSNP
rs753214024 42 dbSNP
rs556484226 43 dbSNP
rs1316142769 44 dbSNP
rs1462056306 45 dbSNP
rs371368208 47 dbSNP
rs1277183780 48 dbSNP
rs764094629 50 dbSNP
rs1205347965 61 dbSNP
rs906851956 64 dbSNP
rs1276496565 75 dbSNP
rs1456621047 75 dbSNP
rs1195795878 82 dbSNP
rs1041898466 83 dbSNP
rs945793647 85 dbSNP
rs892981408 89 dbSNP
rs1006000772 105 dbSNP
rs1430286375 106 dbSNP
rs1189372558 108 dbSNP
rs1421590994 112 dbSNP
rs1409978118 115 dbSNP
rs539984737 125 dbSNP
rs1169361703 137 dbSNP
rs1397575418 145 dbSNP
rs950535357 146 dbSNP
rs1054178905 153 dbSNP
rs1462689779 153 dbSNP
rs901308907 154 dbSNP
rs1273543358 156 dbSNP
rs1364704456 157 dbSNP
rs1219266371 158 dbSNP
rs931911943 170 dbSNP
rs1316212878 173 dbSNP
rs751256620 183 dbSNP
rs1385233244 187 dbSNP
rs1007129361 191 dbSNP
rs889818891 194 dbSNP
rs567807078 195 dbSNP
rs571178478 200 dbSNP
rs1467462425 208 dbSNP
rs1192946261 212 dbSNP
rs766071340 214 dbSNP
rs1420798625 224 dbSNP
rs1475931799 225 dbSNP
rs762724722 229 dbSNP
rs944075854 230 dbSNP
rs1389608050 231 dbSNP
rs548084606 235 dbSNP
rs1421966215 243 dbSNP
rs762498509 244 dbSNP
rs1166887493 247 dbSNP
rs924021791 250 dbSNP
rs1452966906 252 dbSNP
rs982869358 253 dbSNP
rs1478157934 261 dbSNP
rs1278163488 263 dbSNP
rs1248152162 272 dbSNP
rs13306148 273 dbSNP
rs951403038 274 dbSNP
rs1196125511 281 dbSNP
rs949275616 284 dbSNP
rs750015513 286 dbSNP
rs917744622 287 dbSNP
rs990722083 288 dbSNP
rs1456228455 294 dbSNP
rs1226880953 295 dbSNP
rs1384534196 297 dbSNP
rs1286084511 301 dbSNP
rs1257207331 307 dbSNP
rs959270704 309 dbSNP
rs527711374 317 dbSNP
rs182375643 318 dbSNP
rs974211754 333 dbSNP
rs958848978 337 dbSNP
rs1187644848 344 dbSNP
rs1367471314 345 dbSNP
rs1219650647 347 dbSNP
rs984884585 360 dbSNP
rs556387749 364 dbSNP
rs1276875583 365 dbSNP
rs138176506 373 dbSNP
rs1231134250 376 dbSNP
rs1298069664 379 dbSNP
rs1359215513 385 dbSNP
rs548702396 397 dbSNP
rs764619276 398 dbSNP
rs1334913103 411 dbSNP
rs1340021116 414 dbSNP
rs1242844284 415 dbSNP
rs906897536 416 dbSNP
rs1019914851 417 dbSNP
rs538033325 419 dbSNP
rs1398481186 420 dbSNP
rs4907299 423 dbSNP
rs1440234042 429 dbSNP
rs1183506625 433 dbSNP
rs545807537 434 dbSNP
rs931839908 435 dbSNP
rs565885152 438 dbSNP
rs900331187 443 dbSNP
rs1170497256 458 dbSNP
rs1453226603 461 dbSNP
rs29000571 463 dbSNP
rs1394959300 465 dbSNP
rs530660031 472 dbSNP
rs763907974 474 dbSNP
rs1456377739 476 dbSNP
rs944602868 477 dbSNP
rs527687674 478 dbSNP
rs1377935929 481 dbSNP
rs1042904224 485 dbSNP
rs912555463 490 dbSNP
rs1210525183 491 dbSNP
rs1372999608 491 dbSNP
rs1233842264 494 dbSNP
rs1255390853 497 dbSNP
rs1047071090 503 dbSNP
rs896353880 504 dbSNP
rs566816240 507 dbSNP
rs930060334 508 dbSNP
rs1457049633 514 dbSNP
rs937824429 515 dbSNP
rs920038585 516 dbSNP
rs560037946 518 dbSNP
rs909137004 519 dbSNP
rs974139681 520 dbSNP
rs760396139 521 dbSNP
rs927477043 528 dbSNP
rs1279527180 530 dbSNP
rs548591271 534 dbSNP
rs540121216 535 dbSNP
rs1361281678 544 dbSNP
rs1387156999 551 dbSNP
rs145519326 554 dbSNP
rs775706621 556 dbSNP
rs1300451976 557 dbSNP
rs976265274 562 dbSNP
rs965798169 563 dbSNP
rs1278277702 564 dbSNP
rs1316805453 573 dbSNP
rs1196342886 574 dbSNP
rs1274689786 575 dbSNP
rs1433729519 584 dbSNP
rs1210816417 587 dbSNP
rs1019927108 591 dbSNP
rs1360837988 594 dbSNP
rs191577530 609 dbSNP
rs1437325214 613 dbSNP
rs1017341480 617 dbSNP
rs544150391 622 dbSNP
rs1292740307 632 dbSNP
rs1388377306 636 dbSNP
rs35994755 636 dbSNP
rs1001121437 637 dbSNP
rs902533572 642 dbSNP
rs1294675647 654 dbSNP
rs995873107 655 dbSNP
rs1013513759 657 dbSNP
rs772400466 660 dbSNP
rs1186002148 665 dbSNP
rs1219404950 666 dbSNP
rs558589033 668 dbSNP
rs1487980372 670 dbSNP
rs1191600037 677 dbSNP
rs1055095826 678 dbSNP
rs1424596337 684 dbSNP
rs1164401170 688 dbSNP
rs539669669 689 dbSNP
rs2733970 696 dbSNP
rs577495626 697 dbSNP
rs1359828957 698 dbSNP
rs1397527374 707 dbSNP
rs746075861 713 dbSNP
rs1304065401 718 dbSNP
rs929986509 721 dbSNP
rs919924647 722 dbSNP
rs774533357 725 dbSNP
rs1320241153 726 dbSNP
rs1242807556 727 dbSNP
rs1038500360 732 dbSNP
rs929221874 733 dbSNP
rs1229400239 736 dbSNP
rs1215155116 737 dbSNP
rs919138871 748 dbSNP
rs1381724645 750 dbSNP
rs1483649963 761 dbSNP
rs13306149 766 dbSNP
rs927456848 767 dbSNP
rs981610883 770 dbSNP
rs1441249326 771 dbSNP
rs975790769 772 dbSNP
rs770863217 776 dbSNP
rs1417785725 779 dbSNP
rs1178193946 782 dbSNP
rs913508878 783 dbSNP
rs1299710020 788 dbSNP
rs760888362 791 dbSNP
rs1344127303 797 dbSNP
rs1310427855 812 dbSNP
rs957067948 824 dbSNP
rs1281377760 825 dbSNP
rs1032603953 840 dbSNP
rs1312810943 845 dbSNP
rs3813662 850 dbSNP
rs980122991 854 dbSNP
rs1459248600 858 dbSNP
rs1179571080 863 dbSNP
rs756557066 871 dbSNP
rs1019205302 880 dbSNP
rs534484437 882 dbSNP
rs1478047816 887 dbSNP
rs1013544946 888 dbSNP
rs1379513423 889 dbSNP
rs138645845 891 dbSNP
rs1330308368 906 dbSNP
rs1264140933 909 dbSNP
rs562946970 914 dbSNP
rs1033759772 916 dbSNP
rs1219217516 926 dbSNP
rs538196617 928 dbSNP
rs1241610443 929 dbSNP
rs185624106 932 dbSNP
rs994750623 934 dbSNP
rs1199484713 937 dbSNP
rs1048899131 941 dbSNP
rs45568638 958 dbSNP
rs1223501028 959 dbSNP
rs1247153992 963 dbSNP
rs373071216 966 dbSNP
rs552610795 967 dbSNP
rs1477888266 969 dbSNP
rs1233035594 978 dbSNP
rs1408518628 979 dbSNP
rs781405076 983 dbSNP
rs1319067981 991 dbSNP
rs532203315 997 dbSNP
rs1350898666 999 dbSNP
rs1436355008 1001 dbSNP
rs369276346 1001 dbSNP
rs910215044 1006 dbSNP
rs1342395413 1008 dbSNP
rs1050193874 1022 dbSNP
rs181713863 1026 dbSNP
rs1230297914 1027 dbSNP
rs1290319184 1029 dbSNP
rs1450858653 1030 dbSNP
rs1220125095 1032 dbSNP
rs1187036724 1042 dbSNP
rs1360590620 1044 dbSNP
rs925666849 1049 dbSNP
rs1046213312 1052 dbSNP
rs29000572 1063 dbSNP
rs764827329 1064 dbSNP
rs1473573318 1068 dbSNP
rs967242711 1070 dbSNP
rs529942240 1076 dbSNP
rs189142434 1077 dbSNP
rs756684192 1081 dbSNP
rs796969517 1092 dbSNP
rs1400628855 1093 dbSNP
rs1465901848 1095 dbSNP
rs974405311 1097 dbSNP
rs964717576 1099 dbSNP
rs1033622554 1107 dbSNP
rs1285054826 1108 dbSNP
rs1324826051 1108 dbSNP
rs185994066 1116 dbSNP
rs988853034 1122 dbSNP
rs1018722044 1134 dbSNP
rs1426948195 1135 dbSNP
rs987626193 1136 dbSNP
rs955128423 1140 dbSNP
rs1419161475 1143 dbSNP
rs575151053 1145 dbSNP
rs564861251 1146 dbSNP
rs994760343 1154 dbSNP
rs1259018491 1158 dbSNP
rs1443692267 1184 dbSNP
rs899058556 1189 dbSNP
rs1187755938 1194 dbSNP
rs1236566041 1198 dbSNP
rs1017364312 1200 dbSNP
rs29000573 1203 dbSNP
rs140847349 1204 dbSNP
rs753780141 1208 dbSNP
rs950144071 1213 dbSNP
rs1225765392 1220 dbSNP
rs888811857 1220 dbSNP
rs1050102730 1224 dbSNP
rs891964741 1225 dbSNP
rs1053190305 1227 dbSNP
rs554401747 1242 dbSNP
rs1377416445 1243 dbSNP
rs1220430849 1244 dbSNP
rs936268871 1249 dbSNP
rs1041827792 1250 dbSNP
rs1346458180 1252 dbSNP
rs926235236 1263 dbSNP
rs1200536123 1267 dbSNP
rs975384281 1269 dbSNP
rs1263897413 1278 dbSNP
rs878993585 1279 dbSNP
rs943089900 1280 dbSNP
rs1200213242 1284 dbSNP
rs911541737 1289 dbSNP
rs534341445 1291 dbSNP
rs950408264 1295 dbSNP
rs1026170918 1300 dbSNP
rs973205289 1301 dbSNP
rs963195206 1309 dbSNP
rs1401678006 1310 dbSNP
rs29000574 1310 dbSNP
rs980740831 1312 dbSNP
rs952106546 1318 dbSNP
rs1002523091 1319 dbSNP
rs1329041091 1323 dbSNP
rs555209479 1326 dbSNP
rs1304695759 1335 dbSNP
rs1332772350 1336 dbSNP
rs1354138675 1347 dbSNP
rs1177085603 1357 dbSNP
rs961925526 1359 dbSNP
rs550129572 1362 dbSNP
rs1024687582 1365 dbSNP
rs1014308546 1371 dbSNP
rs1258326496 1376 dbSNP
rs1393357077 1383 dbSNP
rs29000575 1386 dbSNP
rs564247121 1387 dbSNP
rs142587561 1398 dbSNP
rs760596638 1401 dbSNP
rs1200252498 1407 dbSNP
rs1428659255 1408 dbSNP
rs1479511031 1409 dbSNP
rs552430969 1410 dbSNP
rs904688078 1413 dbSNP
rs546034489 1415 dbSNP
rs1256172573 1421 dbSNP
rs566581196 1430 dbSNP
rs1392698851 1431 dbSNP
rs1387246972 1454 dbSNP
rs1345030818 1457 dbSNP
rs546400372 1461 dbSNP
rs529806398 1468 dbSNP
rs892665680 1473 dbSNP
rs1051843278 1474 dbSNP
rs1278359079 1486 dbSNP
rs1378986317 1489 dbSNP
rs148821178 1496 dbSNP
rs1390557502 1497 dbSNP
rs29000576 1502 dbSNP
rs1303578967 1503 dbSNP
rs1358969752 1504 dbSNP
rs939480880 1508 dbSNP
rs1373931241 1512 dbSNP
rs759824225 1514 dbSNP
rs1195948439 1515 dbSNP
rs1264066620 1522 dbSNP
rs147773851 1530 dbSNP
rs1382676316 1546 dbSNP
rs963240487 1547 dbSNP
rs920571419 1567 dbSNP
rs972200607 1575 dbSNP
rs926415599 1577 dbSNP
rs564884933 1580 dbSNP
rs1298273968 1581 dbSNP
rs1183181626 1583 dbSNP
rs1339330743 1584 dbSNP
rs1380153479 1586 dbSNP
rs971025313 1588 dbSNP
rs774394011 1591 dbSNP
rs1024320781 1592 dbSNP
rs953160122 1600 dbSNP
rs1291621066 1601 dbSNP
rs1279213000 1606 dbSNP
rs1216678635 1608 dbSNP
rs1357905374 1619 dbSNP
rs1219519085 1622 dbSNP
rs1014236587 1623 dbSNP
rs780406709 1624 dbSNP
rs1238254021 1627 dbSNP
rs904212761 1630 dbSNP
rs369917442 1641 dbSNP
rs1031757142 1643 dbSNP
rs1159235149 1644 dbSNP
rs1344044535 1648 dbSNP
rs145612437 1651 dbSNP
rs1000231137 1656 dbSNP
rs1304157237 1662 dbSNP
rs1314589166 1669 dbSNP
rs1379465305 1676 dbSNP
rs1451536463 1685 dbSNP
rs1314787149 1686 dbSNP
rs528195262 1695 dbSNP
rs1381091453 1699 dbSNP
rs904699219 1702 dbSNP
rs1242918929 1717 dbSNP
rs1412772265 1733 dbSNP
rs1039575527 1734 dbSNP
rs1353759444 1735 dbSNP
rs1213740349 1739 dbSNP
rs1257918291 1744 dbSNP
rs1007828158 1747 dbSNP
rs890674101 1748 dbSNP
rs1483699980 1759 dbSNP
rs1052004997 1763 dbSNP
rs1203321637 1769 dbSNP
rs549146717 1780 dbSNP
rs1400636984 1783 dbSNP
rs928980321 1794 dbSNP
rs559448446 1795 dbSNP
rs540844696 1802 dbSNP
rs918917449 1806 dbSNP
rs1407174549 1808 dbSNP
rs1416735212 1812 dbSNP
rs1177589802 1813 dbSNP
rs1453690364 1824 dbSNP
rs1369613778 1825 dbSNP
rs1359299137 1827 dbSNP
rs1037463210 1836 dbSNP
rs182407237 1840 dbSNP
rs554991744 1850 dbSNP
rs926495507 1851 dbSNP
rs1449508800 1859 dbSNP
rs76946607 1865 dbSNP
rs34790807 1866 dbSNP
rs1056772747 1867 dbSNP
rs1222618940 1869 dbSNP
rs1193970748 1870 dbSNP
rs1324426793 1874 dbSNP
rs939554966 1875 dbSNP
rs905366590 1879 dbSNP
rs11464083 1880 dbSNP
rs1192888253 1880 dbSNP
rs1458875561 1880 dbSNP
rs1259069154 1881 dbSNP
rs1479834892 1883 dbSNP
rs1491418179 1883 dbSNP
rs1491184066 1884 dbSNP
rs1356963729 1885 dbSNP
rs1267194584 1887 dbSNP
rs1231206695 1890 dbSNP
rs1173763359 1892 dbSNP
rs1425330523 1893 dbSNP
rs865975612 1901 dbSNP
rs1333920231 1907 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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