pre-miRNA Information | |
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pre-miRNA | hsa-mir-4291 |
Genomic Coordinates | chr9: 93819357 - 93819421 |
Description | Homo sapiens miR-4291 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-4291 | ||||||||||||
Sequence | 11| UUCAGCAGGAACAGCU |26 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | SOLiD | ||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ADRA2B | ||||||||||||||||||||
Synonyms | ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR | ||||||||||||||||||||
Description | adrenoceptor alpha 2B | ||||||||||||||||||||
Transcript | NM_000682 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ADRA2B | |||||||||||||||||||||
3'UTR of ADRA2B (miRNA target sites are highlighted) |
>ADRA2B|NM_000682|3'UTR 1 GCCCGCCTGCGCTGCCCCTGTGGGGTTGGTGCGGTGGCGCCGGGGTCACCCTGCTTCTTGCCCTGCTGTGTGTGGCTGCC 81 TCCCCTGGGCTTTCTGCTCCCTGCCCAGATCCTGTAGGCCTCATCTTAGGAACCCCTTGGGAGGGGTGGGCAGGGGGGCT 161 GCTAGCAAGGGTCCCAGTGAAGCTTCCCCTTGCCGGCTTAGCTGTGGGGGACCCCTTCTCCACCCTCTCCCTGAGCACAG 241 GCCGATGGAGGTGGTTCAAATCCTCTGGAACATAGCCAAGACCAGGAGAAGAGAGAGCACTTTCTTCCCAGAGCCCCATG 321 CTCTCCAGACCAATGTCTGGGCTTCCCTTTCTTGAGGACCTTGTGTTCCTGGCAGGTCACTTGCTTGTGGTGTTTTCGTT 401 TCTTTTTCATCTCCCCCCCACCCACAAAGAGCACGGAGCCAGCCTTCCACTTTTCCCAGTGGGGCCTGCTGCTGAGGGGG 481 AGGAAGAAACGAAGACTGATCACCCACGCTAGGCACTCGCGGTCCCTGGCAGGCGCTGGGATGGGGGCTTATGGGGTGGC 561 ATCGTCTCTGGGCCCTCCTTTCCCCCTTTGCCTGTTTTCGGATCTGTGGTTCCTTTGAAAGCCAGAACAATGGATCGGCT 641 TCCTTACCCAGCACCCCTCCGGTAGGTGGGTGGCCACGTGGATGCCTCGCTGGGGCGGTCTTGGAGGCCTGGTCTCTGCC 721 TCGACGGGAGATCCCCGATCACTGGCATTCACCCCCTGCAAAAATCGGGGCGACAATAGCTCACTGCCTACTTGCTGCAG 801 GGAGATGAAAGGCTTTGCAGAAAGCTTTGAGCTCTGTGGGGGAACACACTAGAGAACCAAAAATGTGATTATATGGTGAT 881 ATAAAAATCCCTTTCCTCTGTGTTTACCACCACCTGTCTTCCTGTAGACTTTTGTTCTGTCCCTGGGGTGTGTGAATTCC 961 TACCCCGAACTGGAAGCCGGGAGTGGCAGACAGAATCACTATTTCAAGTTAAAGGATCTCTTTGAGAATGTGTTCTTCTG 1041 GCTGCAAAGGTCTGAGTTATTACGCTACATGACAACGTTTCGACATTTCACCGGCAACACCAAGAGGGTTTTTAGTGGCT 1121 TGGGTCTCCCCAGTGGGGGATAAGTCTTTTGTCATCAAGGAGGCAAATTGTCTCCCCAAGACAGCTCAAAATATCCACAC 1201 CTCGGCAACAGTCTAAGATGAGAGCCTGTGACAGGTGGCAGCGCCCCCAGGTGGGGTACTGGCATCAGAGCCTGGTGCGC 1281 CCCTAGGGGAGCCTCCCACTGGAGTGCCCGGCCAGGTCTCCAAGCCCCAAATGAGTCCTTGTGAACCACAACTGATCCCC 1361 CCAGGTGGGTGCTTGTGGACTGCCTCGGACCCAGCCACGCTGCTCCCCGCAATGCTGATGGGGCTGTGCATTGAGGACCC 1441 CTGCTTCCTGGTTCTCAGTCCCACCCCAAAACCTGGCACCCAGAACAGTTGGAAGTGTGGAAAGGAGGTTTATCGGCCTT 1521 CCCTTGGAGAGGGCCTGGCTTCAACATTGGGCCAGTAGGCATCTTAGCTTGGCAGGTGTCGGGGGAATGGGCCAGATGGA 1601 CCTGCTAGATTTGGAAGGGCACCGAGGGAGTTTTCTGGGTGTAGAGAGAATGGAGGGGACCAAAAAGAGTCCTTCCTGGG 1681 GTGTGGGAGGCTTCCCAGCTTGGTCCTCAGTGGGTTGTTGAGGCCAGAGTATCGCCCTGGGATGTGGTGGGGAGCTGGGC 1761 CAGGAGAGGGACTGACTGTGACCCTCTGCTGGCCGGTCTTGTGTGCGCCCCATGGGACCCCCAGTGTTCTTGCCTGTGAC 1841 CTCTTATTGCGACATGCAGGTGGTGTTTTTTTTTTTTTTAAACTCTGAGCTATTTTATCAATAAAGGATATTTTGTAATA 1921 AG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293S |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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82 hsa-miR-4291 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT102445 | CALU | calumenin | ![]() |
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2 | 4 | ||||||
MIRT108677 | ZBTB33 | zinc finger and BTB domain containing 33 | ![]() |
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2 | 4 | ||||||
MIRT125969 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
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2 | 6 | ||||||
MIRT179018 | PAFAH1B2 | platelet activating factor acetylhydrolase 1b catalytic subunit 2 | ![]() |
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2 | 4 | ||||||
MIRT379033 | CDK6 | cyclin dependent kinase 6 | ![]() |
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2 | 6 | ||||||
MIRT442473 | CPEB4 | cytoplasmic polyadenylation element binding protein 4 | ![]() |
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2 | 2 | ||||||
MIRT442910 | PCBD2 | pterin-4 alpha-carbinolamine dehydratase 2 | ![]() |
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2 | 2 | ||||||
MIRT442979 | ZNF736 | zinc finger protein 736 | ![]() |
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2 | 2 | ||||||
MIRT445663 | TNFSF15 | TNF superfamily member 15 | ![]() |
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2 | 2 | ||||||
MIRT446237 | FZD6 | frizzled class receptor 6 | ![]() |
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2 | 2 | ||||||
MIRT448860 | FAM49B | family with sequence similarity 49 member B | ![]() |
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2 | 2 | ||||||
MIRT455559 | TRAF1 | TNF receptor associated factor 1 | ![]() |
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2 | 2 | ||||||
MIRT459704 | ZNF641 | zinc finger protein 641 | ![]() |
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2 | 2 | ||||||
MIRT460608 | FEM1A | fem-1 homolog A | ![]() |
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2 | 2 | ||||||
MIRT462251 | LAMA4 | laminin subunit alpha 4 | ![]() |
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2 | 2 | ||||||
MIRT462469 | FIZ1 | FLT3 interacting zinc finger 1 | ![]() |
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2 | 2 | ||||||
MIRT466656 | TAF1D | TATA-box binding protein associated factor, RNA polymerase I subunit D | ![]() |
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2 | 6 | ||||||
MIRT466841 | STX6 | syntaxin 6 | ![]() |
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2 | 2 | ||||||
MIRT471403 | PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT471517 | PCGF3 | polycomb group ring finger 3 | ![]() |
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2 | 2 | ||||||
MIRT471681 | PABPN1 | poly(A) binding protein nuclear 1 | ![]() |
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2 | 2 | ||||||
MIRT472858 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | ![]() |
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2 | 2 | ||||||
MIRT474813 | KIAA0226 | RUN and cysteine rich domain containing beclin 1 interacting protein | ![]() |
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2 | 2 | ||||||
MIRT474931 | KCTD15 | potassium channel tetramerization domain containing 15 | ![]() |
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2 | 2 | ||||||
MIRT475814 | HDGF | heparin binding growth factor | ![]() |
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2 | 2 | ||||||
MIRT480434 | C17orf49 | chromosome 17 open reading frame 49 | ![]() |
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2 | 2 | ||||||
MIRT480903 | BCL2L2-PABPN1 | BCL2L2-PABPN1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT481478 | ARL8B | ADP ribosylation factor like GTPase 8B | ![]() |
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2 | 2 | ||||||
MIRT484982 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 8 | ||||||
MIRT485019 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 8 | ||||||
MIRT485036 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 8 | ||||||
MIRT495074 | HEYL | hes related family bHLH transcription factor with YRPW motif-like | ![]() |
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2 | 2 | ||||||
MIRT496004 | CD180 | CD180 molecule | ![]() |
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2 | 2 | ||||||
MIRT500675 | TRIM37 | tripartite motif containing 37 | ![]() |
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2 | 2 | ||||||
MIRT504544 | ZNF417 | zinc finger protein 417 | ![]() |
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2 | 6 | ||||||
MIRT506782 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 6 | ||||||
MIRT507256 | FGF2 | fibroblast growth factor 2 | ![]() |
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2 | 6 | ||||||
MIRT507386 | EN2 | engrailed homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT512505 | BTBD19 | BTB domain containing 19 | ![]() |
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2 | 2 | ||||||
MIRT516903 | CTSB | cathepsin B | ![]() |
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2 | 2 | ||||||
MIRT528124 | PPP1R10 | protein phosphatase 1 regulatory subunit 10 | ![]() |
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2 | 2 | ||||||
MIRT528874 | ATF3 | activating transcription factor 3 | ![]() |
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2 | 2 | ||||||
MIRT536091 | MBOAT2 | membrane bound O-acyltransferase domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT541079 | RLIM | ring finger protein, LIM domain interacting | ![]() |
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2 | 2 | ||||||
MIRT541099 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase | ![]() |
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2 | 2 | ||||||
MIRT545360 | LIN7C | lin-7 homolog C, crumbs cell polarity complex component | ![]() |
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2 | 2 | ||||||
MIRT545831 | ZNF367 | zinc finger protein 367 | ![]() |
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2 | 4 | ||||||
MIRT547115 | PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | ![]() |
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2 | 2 | ||||||
MIRT547312 | NPTN | neuroplastin | ![]() |
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2 | 2 | ||||||
MIRT547959 | HIGD1A | HIG1 hypoxia inducible domain family member 1A | ![]() |
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2 | 4 | ||||||
MIRT549943 | RPL7L1 | ribosomal protein L7 like 1 | ![]() |
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2 | 2 | ||||||
MIRT550749 | ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | ![]() |
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2 | 2 | ||||||
MIRT565145 | TUBB2A | tubulin beta 2A class IIa | ![]() |
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2 | 2 | ||||||
MIRT571050 | POLQ | DNA polymerase theta | ![]() |
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2 | 2 | ||||||
MIRT571361 | ZNF45 | zinc finger protein 45 | ![]() |
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2 | 2 | ||||||
MIRT610133 | FOXI2 | forkhead box I2 | ![]() |
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2 | 2 | ||||||
MIRT613145 | DSE | dermatan sulfate epimerase | ![]() |
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2 | 2 | ||||||
MIRT613379 | ABCC12 | ATP binding cassette subfamily C member 12 | ![]() |
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2 | 2 | ||||||
MIRT615752 | C6 | complement C6 | ![]() |
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2 | 2 | ||||||
MIRT616460 | ADRA2B | adrenoceptor alpha 2B | ![]() |
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2 | 2 | ||||||
MIRT616719 | FEM1B | fem-1 homolog B | ![]() |
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2 | 2 | ||||||
MIRT618312 | IPP | intracisternal A particle-promoted polypeptide | ![]() |
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2 | 2 | ||||||
MIRT631491 | RASSF4 | Ras association domain family member 4 | ![]() |
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2 | 2 | ||||||
MIRT643134 | PLCXD2 | phosphatidylinositol specific phospholipase C X domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT643482 | DISC1 | disrupted in schizophrenia 1 | ![]() |
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2 | 2 | ||||||
MIRT649715 | TWSG1 | twisted gastrulation BMP signaling modulator 1 | ![]() |
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2 | 2 | ||||||
MIRT653542 | SLC38A7 | solute carrier family 38 member 7 | ![]() |
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2 | 2 | ||||||
MIRT666307 | SLC22A3 | solute carrier family 22 member 3 | ![]() |
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2 | 2 | ||||||
MIRT692005 | NAP1L4 | nucleosome assembly protein 1 like 4 | ![]() |
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2 | 2 | ||||||
MIRT696838 | ARL2BP | ADP ribosylation factor like GTPase 2 binding protein | ![]() |
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2 | 2 | ||||||
MIRT698204 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT703316 | GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT709376 | FAM13A | family with sequence similarity 13 member A | ![]() |
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2 | 2 | ||||||
MIRT710112 | MED23 | mediator complex subunit 23 | ![]() |
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2 | 2 | ||||||
MIRT711975 | HOMER2 | homer scaffolding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT712275 | PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT714108 | TMED9 | transmembrane p24 trafficking protein 9 | ![]() |
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2 | 2 | ||||||
MIRT719113 | MAML1 | mastermind like transcriptional coactivator 1 | ![]() |
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2 | 2 | ||||||
MIRT719727 | SLC39A11 | solute carrier family 39 member 11 | ![]() |
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2 | 2 | ||||||
MIRT720018 | TFAP2C | transcription factor AP-2 gamma | ![]() |
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2 | 2 | ||||||
MIRT720358 | ZBTB8B | zinc finger and BTB domain containing 8B | ![]() |
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2 | 2 | ||||||
MIRT720372 | NUDT3 | nudix hydrolase 3 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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