miRTarBase - #MIRT616589


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pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KLHL9   
Synonyms -
Description kelch like family member 9
Transcript NM_018847   
Expression
Putative miRNA Targets on KLHL9
3'UTR of KLHL9
(miRNA target sites are highlighted)		 
>KLHL9|NM_018847|3'UTR
   1 GTCTAAGGTGTAACACCTTTGCAGTACGTCATGGGTGATCTAATACTTCCCCTTCAGTTGTATCTTCTTACAGTGATTGG
  81 TACAGTTATTAGATATAAAGGTAACTGATGTTATTCGTCTTGTATGGCTTTTAGTATGTTTATCAAGTGGCTAACAAATG
 161 CATTCTGAAAATGTATTTAACATAGCTGTTTTAACAAATGAAAAAAAGACGTAGAAAAATGTTTAGATGTCTTTTTGTGA
 241 TGTTATATAAAATTGTAGATGACTGTGGTAAATGTGTAATTATGTCCATTATGCTTCAAAGTTGAGTTTTCATCTTTGAC
 321 TCCAAAATGTCAGAGGGAGGCCGCTCTAAACTAAAAATAACGAAAGGTTGCCAAGTATTAATACTAGTTACCTCCCTCTT
 401 TTCGTAGTTTTTGTCATGTCTGTCAACTTACTCGATTGTGTGGTTGCATTCAGAATATTTGAAGTTTCTTACGTAGACAG
 481 AAATAATAAAAATATTAACTAGGAAAAAACAGTATAGCACCAAGCCAGTATTTGGTATCTCTCTCTAGAGCGAGCAAGAG
 561 AGGGAGAGAGGAGGAAAAAATACACATAATACAAACATACATGCATGCACACATACATACATATGTATACACACACATAA
 641 TTTGAAAACTGATTGGCACTTCAACGATGCTGAAATTGTTTTTAAATTGAAGTTTCTTTCTTCCACAAAGCAGCCGTTTC
 721 TATTCAAATGGAAATTCAGTACCAGAGAATAAATGTCTATGTAGTCATACTGAATTTAGATAGATAAGGGCTACAGCATA
 801 CTAAATCGACAACCAAATTTGTCATGTGACTAAACCGTTACTTCAGATGAAGCTTACATTACTGTTTTCTGCTTGTGTAT
 881 TTTCTGTAGAGTACTTTTACACAGATTGGTAAAGTTCAGGTTTCAGAGAACTGCTTTTGTGCAGAAAATTTAGGTTCTTT
 961 TTTCCACCTTTTTGGTCAGTAAAACTTAATGAAAAAAGCAAAGAAAAAAATATTCTGAACAAAGCTATAGGGTTTTAAGT
1041 TCAGCCTCCCAACTTAGTCATCCTAACATGATTATTTTGTGATTTGGGGTGCTTGCCCTGGTGCTGTTCCAGTCCATGTG
1121 CATCCTGAGCTGTGTGATCTGCCTCGAGGCTATGATCTGAGCAAGCAGGAGATAACATTTTCTTCTGCATCAAGTGAGGA
1201 AAAATGTGCTTTTGGCCATGTCTCAAAGACAGGACCAACTTCAGATTCCCAAAGAAGCCAGCTACAGAGCCTCTGGAACA
1281 CTATGGTCTTACAAGCAGTACTAAAATCAACCCTCAGCCTCTTCAATGCCAAAGGTATCCCTATTGGTTGAGAACCACAT
1361 GGTAATTTTTAATGGGACTTTTATCAGCAAATGGAGTTACAGGAATTCTCTGTAATGAGTGATTCTGAAGAGGTACTTTC
1441 CTGGAATAATTGTCTACCTGAAGAAAAAAAATTTATATATACATTGTGTGTGTGTGTAATACACACACACAACCCCCTAT
1521 ACCTGGAAGATTGTCAGCATGTAAATCAGGAACAACTTTCTCCTTATTGACAATCCCATAATAAAACTCAGGAACCAAGG
1601 CAAAATGAATTGGCTTCTAGGGGTCTGAACCTTACTGCCCATACAAGTGTTGATTCATTTTAATGCTGTTTATGATTTCT
1681 GCATTGGCAGAAATTTTCATACTTTCTATGTTTTTTTAATTACTCAGTTTTTTATTACTAAAAATAGCACATTTGAGTAC
1761 ATTTGAAAAGTAGAAAAATTAGAAATTATTAACTTTATTGAATAAGCAAGAAGTGCATCCTAATCCTTTGATTATTAATG
1841 AGGTTGAATATTTGTGTGCTATCGGTAGCTGTGTTTCTTTGATCAGATGTTCCTGTCCTTTTGCCCTTCTGTTATCTGTT
1921 GGAGTTGCTTTGTTTTTCGTATCAAGTTATAGGATCTCTTTATATAATAAATGTAATTTAACTTGCATTTGCTTGCATTT
2001 ATTTCTTCCCTCAATCTGTTGTAGTTTTACAAAGGCAACGCTGTTCAGTTAATTTTTGAGATCAAATTTGTCTTTTTTTT
2081 TTTTTGAGACAGGGTCTCACTGTTGTGCAGTCTGGAGTGCAATGGCACGATGTGTGCTCACTGAAACCTCTGCCTCTCAT
2161 GTTCAGGCGATTCTCCCACCTCAGCCTCCCGATTAGCTGGGATTACAGGCATGTACCACCAAGCCCGGCTAATTTTGTAT
2241 TTTTAGTAGAGATGGGGTTAGGGGATAATTTTGATATGGTTTATTTTTTATGTAGTATTTCAGTGCTTATTCTGACATAT
2321 CAAGGTGATACTGCCCTGCCTCTATTTTGTACAGGCTTTTCCTTTTATTGAAAAAAAGTACTTTTTATTACATCTTATGT
2401 CTGAACCTGGTGCTTCCTATTGAAATAAGTATTGCTTTACTAGGTAAACTGCTCTATCTACATCCCCCACCTCCAGCTTC
2481 ACCCACCCTGCCTCTCATTTTTTTACTTTCCCGTATTCTGCAGTTGACAGTTCTCTTGGTAATCATACAGGTAGCTGACT
2561 AATGCTATGCTAATACAGGTTGAGCAGCCCTAATCCAAAAATCCAAATTGCTCCAAAATTTAAAACTTTTTGAGGGCCAA
2641 CAGGATGCCACAAGTAGAAAATTCCACACCAGAGCTCATGTGACAGGTTACACTCAAAACACAGTGAAGACTTGTTTCAT
2721 GCACAACATTATTAAGACTATTATAATTACCTTCAGACTACGTGTCTGAAACGTGAAATATAACCGAAGTTTTAAGTAAT
2801 ATTGTTTAGACTTGGGTCCCTCCCCCAGGATACGTCATGTACATGCAAATATTCCAAAATCCAAAACACTTCTGGTCCCA
2881 AGCATTTCAGATAAGGGATATTCAATCTGTACTGCTCATTAAACCTGGAGTTTCTTATAGAGAGAAATTTTAGGTGGTTG
2961 AAATGATTAAATGGAAAGAGATTTATTTTCATAAGCTGGTAATTTTTTAAAGAAAGTTCAGACTGGAAAAATATTTAGAG
3041 GATAAAAACTAAAAGCACATAAAGCATTATGTTAACATTTCTTGTTTTAGTTTTTCGGAAAGTATTCAAAAATTAACATT
3121 TGTTAGCTTTTTTGATATGTCTATTATAGAACGTACAGGAAAATAAAAGCAAACTAATTTATCAGTGATTCCACATGTTG
3201 AAGATAATTTCTATTAATAGTATATTATATATATATATATACGTACATATGTGCAGGCATTTGTCAAATATTTTTCAAGT
3281 ATGCCAGACCTTAGGCTAAAAGCTGGATAATGAAAATAAATCCACCTTCCAAAGAAAAAAAAAAAAAAAAAAAAAAAAAA
3361 AAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUCGU---UC-UGGGGCAGAGAUUu 5'
            ||:|   :| |:|:| ||||||: 
Target 5' ccAGTATTTGGTATCTC-TCTCTAGa 3'
 525 - 549 135.00 -13.00
2 
miRNA  3' ucUCGUUCUGGGGCAGAGAUUu 5'
            || :||:||    |||||| 
Target 5' agAGGGAGGCCG---CTCTAAa 3'
 332 - 350 128.00 -19.60
3 
miRNA  3' ucucguuCUGGGGCAGAGAUUu 5'
                 |:|| :||||| || 
Target 5' tgcttttGGCCATGTCTCAAAg 3'
 1207 - 1228 127.00 -14.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30512276 3 COSMIC
COSN30130926 28 COSMIC
COSN30454971 41 COSMIC
COSN32065204 64 COSMIC
COSN30515169 68 COSMIC
COSN23402089 94 COSMIC
COSN30114598 116 COSMIC
COSN26350850 435 COSMIC
COSN31589137 716 COSMIC
COSN31514891 806 COSMIC
COSN31582525 807 COSMIC
COSN20552597 946 COSMIC
COSN31528135 991 COSMIC
COSN31565365 1052 COSMIC
COSN26579437 1171 COSMIC
COSN20106079 1500 COSMIC
COSN9705456 1511 COSMIC
COSN20661807 1674 COSMIC
COSN31595550 1679 COSMIC
COSN6384476 1893 COSMIC
COSN26572899 1928 COSMIC
COSN31538451 1939 COSMIC
COSN31531352 1953 COSMIC
COSN31486584 1958 COSMIC
COSN7562016 2268 COSMIC
COSN21492028 2786 COSMIC
COSN22525297 2829 COSMIC
COSN2497505 2924 COSMIC
COSN16321567 3112 COSMIC
COSN6384475 3141 COSMIC
COSN23157651 3226 COSMIC
rs10116615 1886 GWAS
rs10117202 1886 GWAS
rs10811523 1886 GWAS
rs10811524 1886 GWAS
rs10811525 1886 GWAS
rs10811527 1886 GWAS
rs10811529 1886 GWAS
rs10964957 1886 GWAS
rs1330314 1886 GWAS
rs1360286 1886 GWAS
rs2094787 1886 GWAS
rs2094788 1886 GWAS
rs4406500 1886 GWAS
rs4582643 1886 GWAS
rs7862030 1886 GWAS
rs7868542 1886 GWAS
rs8729 1886 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749001440 8 dbSNP
rs775094369 14 dbSNP
rs373813393 16 dbSNP
rs781204627 17 dbSNP
rs932509381 18 dbSNP
rs151217472 20 dbSNP
rs1487375427 21 dbSNP
rs1178668194 22 dbSNP
rs144808151 26 dbSNP
rs373390426 27 dbSNP
rs758565676 28 dbSNP
rs752946329 29 dbSNP
rs1463112154 30 dbSNP
rs955948520 31 dbSNP
rs778788264 32 dbSNP
rs1031726280 39 dbSNP
rs370556194 40 dbSNP
rs1440280762 42 dbSNP
rs552139677 43 dbSNP
rs766902481 46 dbSNP
rs114075268 49 dbSNP
rs759587463 49 dbSNP
rs1397687893 56 dbSNP
rs1042666121 64 dbSNP
rs1287051867 68 dbSNP
rs1302928251 71 dbSNP
rs1356810881 71 dbSNP
rs1292151529 80 dbSNP
rs1461000035 86 dbSNP
rs1353299908 88 dbSNP
rs945578111 95 dbSNP
rs567820351 96 dbSNP
rs1466512343 108 dbSNP
rs141031506 109 dbSNP
rs1022741761 110 dbSNP
rs1476312945 116 dbSNP
rs528023982 117 dbSNP
rs1176716695 124 dbSNP
rs1479677637 127 dbSNP
rs530456881 130 dbSNP
rs1373968485 133 dbSNP
rs1461858200 153 dbSNP
rs1306703850 158 dbSNP
rs867030982 175 dbSNP
rs1013493214 182 dbSNP
rs943536491 193 dbSNP
rs564926340 197 dbSNP
rs1215938399 208 dbSNP
rs1306697627 208 dbSNP
rs146476786 208 dbSNP
rs987214195 208 dbSNP
rs1485918627 210 dbSNP
rs773158084 210 dbSNP
rs775235624 210 dbSNP
rs918887347 210 dbSNP
rs1272320268 211 dbSNP
rs971694536 212 dbSNP
rs1356996030 220 dbSNP
rs1312938043 227 dbSNP
rs993675240 229 dbSNP
rs898093826 232 dbSNP
rs1040751026 233 dbSNP
rs1420564515 234 dbSNP
rs1167029961 245 dbSNP
rs1397308705 249 dbSNP
rs1435830681 257 dbSNP
rs1300480220 260 dbSNP
rs749751232 263 dbSNP
rs1466598843 264 dbSNP
rs889194630 266 dbSNP
rs778270612 269 dbSNP
rs1360765228 273 dbSNP
rs1394305881 274 dbSNP
rs1432448113 283 dbSNP
rs1305304085 294 dbSNP
rs1348386758 310 dbSNP
rs1016166482 312 dbSNP
rs1233438483 314 dbSNP
rs991763324 321 dbSNP
rs1463301621 322 dbSNP
rs958538350 331 dbSNP
rs946787714 342 dbSNP
rs188443438 343 dbSNP
rs1464582459 345 dbSNP
rs1003591058 346 dbSNP
rs1255258609 356 dbSNP
rs1455010507 357 dbSNP
rs1417460505 358 dbSNP
rs989996836 361 dbSNP
rs1179259433 362 dbSNP
rs41270131 370 dbSNP
rs1423748503 373 dbSNP
rs924575610 375 dbSNP
rs1402963826 383 dbSNP
rs1252241678 386 dbSNP
rs981500378 392 dbSNP
rs1358162609 395 dbSNP
rs1265711489 396 dbSNP
rs542423591 397 dbSNP
rs1327552702 403 dbSNP
rs971120712 403 dbSNP
rs41270129 404 dbSNP
rs1439975841 412 dbSNP
rs781269561 416 dbSNP
rs1375356565 418 dbSNP
rs1446805398 423 dbSNP
rs41270127 428 dbSNP
rs1324425477 429 dbSNP
rs1443626819 433 dbSNP
rs894077505 434 dbSNP
rs1469178069 438 dbSNP
rs1391883299 444 dbSNP
rs540533636 446 dbSNP
rs1471417698 453 dbSNP
rs1451896452 459 dbSNP
rs1365694629 467 dbSNP
rs578029870 468 dbSNP
rs555369876 472 dbSNP
rs750165321 473 dbSNP
rs116599440 476 dbSNP
rs1356086984 477 dbSNP
rs1442811240 487 dbSNP
rs1278925041 488 dbSNP
rs898061128 494 dbSNP
rs1051956965 495 dbSNP
rs776788184 497 dbSNP
rs933103381 504 dbSNP
rs1009312734 512 dbSNP
rs757149365 514 dbSNP
rs1288108434 515 dbSNP
rs753770826 517 dbSNP
rs10120531 527 dbSNP
rs536650718 535 dbSNP
rs1054272015 541 dbSNP
rs1417994823 547 dbSNP
rs1472234144 547 dbSNP
rs192832956 551 dbSNP
rs567505921 552 dbSNP
rs1484697695 556 dbSNP
rs1287658352 558 dbSNP
rs1240280617 568 dbSNP
rs1045688071 578 dbSNP
rs950010726 590 dbSNP
rs766666629 592 dbSNP
rs188385691 594 dbSNP
rs1301950242 597 dbSNP
rs981266325 600 dbSNP
rs1236057981 601 dbSNP
rs951773746 602 dbSNP
rs566297060 603 dbSNP
rs534204456 604 dbSNP
rs1332112395 607 dbSNP
rs970841030 616 dbSNP
rs972190338 623 dbSNP
rs1257581096 624 dbSNP
rs1380834138 624 dbSNP
rs1390455448 625 dbSNP
rs1441379858 627 dbSNP
rs1184950971 630 dbSNP
rs1387452068 632 dbSNP
rs760097330 633 dbSNP
rs1021032831 638 dbSNP
rs767186535 638 dbSNP
rs1298996059 640 dbSNP
rs1009584486 642 dbSNP
rs1373692775 644 dbSNP
rs1171759950 645 dbSNP
rs1478971476 650 dbSNP
rs775122032 651 dbSNP
rs549064421 656 dbSNP
rs571634730 658 dbSNP
rs1033007411 664 dbSNP
rs1007775614 667 dbSNP
rs1192232748 673 dbSNP
rs1332289834 680 dbSNP
rs551334378 691 dbSNP
rs1426476290 699 dbSNP
rs1436134775 702 dbSNP
rs1297266763 703 dbSNP
rs889356384 703 dbSNP
rs531747688 706 dbSNP
rs16938346 710 dbSNP
rs116816721 711 dbSNP
rs897610022 716 dbSNP
rs1485093757 720 dbSNP
rs1277571274 723 dbSNP
rs1009118384 727 dbSNP
rs759270700 731 dbSNP
rs1346352075 734 dbSNP
rs1285748059 747 dbSNP
rs1447176012 749 dbSNP
rs1187562974 756 dbSNP
rs1245938894 757 dbSNP
rs941719735 759 dbSNP
rs908840874 761 dbSNP
rs1056126040 764 dbSNP
rs937309724 764 dbSNP
rs774020191 777 dbSNP
rs1170852921 780 dbSNP
rs1028975465 784 dbSNP
rs1457950338 785 dbSNP
rs1320194319 786 dbSNP
rs771232622 787 dbSNP
rs1443640708 789 dbSNP
rs1302425459 805 dbSNP
rs1010935597 808 dbSNP
rs1261919261 811 dbSNP
rs893882417 823 dbSNP
rs967174850 836 dbSNP
rs144046934 837 dbSNP
rs1469546461 840 dbSNP
rs113124901 846 dbSNP
rs540468523 858 dbSNP
rs1183968940 861 dbSNP
rs1365579630 863 dbSNP
rs1045981347 872 dbSNP
rs1472999350 875 dbSNP
rs773646866 876 dbSNP
rs1158687736 877 dbSNP
rs1402861670 879 dbSNP
rs577984287 890 dbSNP
rs1463211285 891 dbSNP
rs373483274 893 dbSNP
rs953675472 896 dbSNP
rs761044046 903 dbSNP
rs1194023908 905 dbSNP
rs1227185379 910 dbSNP
rs1285918164 914 dbSNP
rs1336441998 919 dbSNP
rs1030525347 934 dbSNP
rs997655022 938 dbSNP
rs770401512 940 dbSNP
rs1474682334 942 dbSNP
rs1252524909 953 dbSNP
rs773826111 955 dbSNP
rs1189050791 966 dbSNP
rs1442461490 968 dbSNP
rs1272984126 976 dbSNP
rs182779651 992 dbSNP
rs748166792 998 dbSNP
rs1368222806 999 dbSNP
rs1036074821 1000 dbSNP
rs1320526546 1003 dbSNP
rs1005936907 1010 dbSNP
rs1259114193 1011 dbSNP
rs1305589646 1013 dbSNP
rs887516278 1020 dbSNP
rs1396224226 1021 dbSNP
rs920344825 1026 dbSNP
rs575196823 1032 dbSNP
rs971751604 1039 dbSNP
rs781383433 1044 dbSNP
rs1319691295 1045 dbSNP
rs1353825403 1048 dbSNP
rs1275092288 1057 dbSNP
rs1341316532 1059 dbSNP
rs936984416 1060 dbSNP
rs1484300610 1062 dbSNP
rs1182659277 1068 dbSNP
rs1255806295 1070 dbSNP
rs1286136457 1071 dbSNP
rs1170831558 1072 dbSNP
rs912037327 1079 dbSNP
rs1429648864 1083 dbSNP
rs1335227383 1089 dbSNP
rs1376743090 1092 dbSNP
rs1045653885 1093 dbSNP
rs1301772007 1097 dbSNP
rs145481658 1098 dbSNP
rs1383590127 1100 dbSNP
rs945865976 1104 dbSNP
rs988064614 1109 dbSNP
rs1444476026 1113 dbSNP
rs913034507 1114 dbSNP
rs953637087 1116 dbSNP
rs1182768782 1121 dbSNP
rs535524892 1125 dbSNP
rs755126268 1137 dbSNP
rs190960396 1146 dbSNP
rs1010904578 1149 dbSNP
rs1249005553 1152 dbSNP
rs1449317882 1155 dbSNP
rs1187214339 1169 dbSNP
rs925339696 1177 dbSNP
rs986175283 1186 dbSNP
rs553924541 1187 dbSNP
rs953476406 1191 dbSNP
rs780446762 1220 dbSNP
rs1454999378 1241 dbSNP
rs1460688525 1259 dbSNP
rs1387630730 1264 dbSNP
rs534147057 1265 dbSNP
rs1030561427 1266 dbSNP
rs1368166751 1278 dbSNP
rs958064012 1282 dbSNP
rs186200675 1283 dbSNP
rs1310559825 1286 dbSNP
rs1231809175 1292 dbSNP
rs1269078901 1292 dbSNP
rs1207147715 1295 dbSNP
rs1178964817 1296 dbSNP
rs1459490659 1297 dbSNP
rs1239269489 1299 dbSNP
rs999582832 1306 dbSNP
rs1191170708 1317 dbSNP
rs1422404385 1322 dbSNP
rs1473324885 1326 dbSNP
rs1213493735 1335 dbSNP
rs1387378742 1343 dbSNP
rs149662895 1344 dbSNP
rs558039931 1347 dbSNP
rs1015081245 1350 dbSNP
rs1291785911 1352 dbSNP
rs1292351851 1359 dbSNP
rs546159322 1360 dbSNP
rs1229092854 1366 dbSNP
rs1289075379 1371 dbSNP
rs906622699 1372 dbSNP
rs1226818032 1381 dbSNP
rs1292437889 1382 dbSNP
rs1452585731 1384 dbSNP
rs1221469659 1386 dbSNP
rs1245540200 1391 dbSNP
rs1045543583 1400 dbSNP
rs1484330564 1401 dbSNP
rs1350134013 1402 dbSNP
rs1410615425 1406 dbSNP
rs537804199 1408 dbSNP
rs569233717 1410 dbSNP
rs757045444 1415 dbSNP
rs74502129 1426 dbSNP
rs1414250448 1435 dbSNP
rs1240808756 1440 dbSNP
rs1404613602 1444 dbSNP
rs1162451789 1448 dbSNP
rs1055670107 1449 dbSNP
rs1410394873 1450 dbSNP
rs1308659455 1457 dbSNP
rs202160903 1458 dbSNP
rs1349999316 1468 dbSNP
rs1331914264 1471 dbSNP
rs1192641136 1472 dbSNP
rs529007983 1472 dbSNP
rs1439954479 1473 dbSNP
rs930566203 1480 dbSNP
rs563227564 1485 dbSNP
rs529374590 1486 dbSNP
rs567001414 1488 dbSNP
rs546780714 1490 dbSNP
rs533168729 1492 dbSNP
rs1001226273 1496 dbSNP
rs564323274 1498 dbSNP
rs761712277 1498 dbSNP
rs770215084 1498 dbSNP
rs906827717 1498 dbSNP
rs945980616 1498 dbSNP
rs10119659 1499 dbSNP
rs201419326 1500 dbSNP
rs33933217 1501 dbSNP
rs10639615 1502 dbSNP
rs1370020982 1504 dbSNP
rs1336260001 1506 dbSNP
rs112740625 1511 dbSNP
rs10642262 1512 dbSNP
rs1447612977 1512 dbSNP
rs77069093 1512 dbSNP
rs202212020 1513 dbSNP
rs370753846 1514 dbSNP
rs891712823 1515 dbSNP
rs1467464186 1519 dbSNP
rs1441436462 1522 dbSNP
rs1185019903 1531 dbSNP
rs1248818241 1542 dbSNP
rs1036002351 1550 dbSNP
rs1449917362 1552 dbSNP
rs1187833227 1555 dbSNP
rs1054317273 1559 dbSNP
rs1282370340 1560 dbSNP
rs1174350454 1562 dbSNP
rs1403030115 1563 dbSNP
rs544488999 1567 dbSNP
rs1335053208 1570 dbSNP
rs182292925 1572 dbSNP
rs911654470 1580 dbSNP
rs987645425 1588 dbSNP
rs1325162837 1591 dbSNP
rs932176194 1592 dbSNP
rs1233465108 1595 dbSNP
rs1343719322 1597 dbSNP
rs922176279 1600 dbSNP
rs986599900 1602 dbSNP
rs1269690331 1605 dbSNP
rs989691250 1606 dbSNP
rs1465077217 1610 dbSNP
rs958284549 1622 dbSNP
rs1436870152 1623 dbSNP
rs1030978478 1624 dbSNP
rs1344271667 1634 dbSNP
rs77895351 1635 dbSNP
rs1199542534 1636 dbSNP
rs1421044789 1637 dbSNP
rs190770136 1641 dbSNP
rs1360590973 1644 dbSNP
rs1378273835 1650 dbSNP
rs970817049 1672 dbSNP
rs1477774748 1674 dbSNP
rs1174387939 1678 dbSNP
rs976049118 1704 dbSNP
rs1457997564 1705 dbSNP
rs760577853 1708 dbSNP
rs962309237 1708 dbSNP
rs1173637140 1710 dbSNP
rs1015112139 1711 dbSNP
rs985006320 1719 dbSNP
rs1431953697 1725 dbSNP
rs1329985415 1726 dbSNP
rs1221090138 1734 dbSNP
rs1289683360 1734 dbSNP
rs111532568 1745 dbSNP
rs576213555 1746 dbSNP
rs1258715499 1747 dbSNP
rs1489380063 1763 dbSNP
rs1025508118 1764 dbSNP
rs1266517221 1772 dbSNP
rs572574474 1777 dbSNP
rs1192167212 1780 dbSNP
rs1475270952 1782 dbSNP
rs1034105251 1788 dbSNP
rs1001656293 1797 dbSNP
rs552667286 1797 dbSNP
rs1473031054 1806 dbSNP
rs1240627496 1807 dbSNP
rs780215819 1811 dbSNP
rs906943923 1813 dbSNP
rs772600694 1814 dbSNP
rs1024016547 1816 dbSNP
rs894276056 1817 dbSNP
rs1309265651 1820 dbSNP
rs764107277 1826 dbSNP
rs1408834458 1830 dbSNP
rs1009886693 1838 dbSNP
rs1323161412 1843 dbSNP
rs1034155727 1848 dbSNP
rs1264673783 1855 dbSNP
rs1357131991 1859 dbSNP
rs1207273704 1862 dbSNP
rs994687490 1863 dbSNP
rs1176819906 1864 dbSNP
rs899108059 1869 dbSNP
rs564383763 1875 dbSNP
rs369218995 1880 dbSNP
rs1219629536 1882 dbSNP
rs8729 1886 dbSNP
rs889580250 1893 dbSNP
rs1275975361 1905 dbSNP
rs1050544190 1906 dbSNP
rs1428477396 1909 dbSNP
rs1295951606 1911 dbSNP
rs932104825 1912 dbSNP
rs1396275559 1914 dbSNP
rs1401462562 1916 dbSNP
rs890204518 1917 dbSNP
rs1380364778 1918 dbSNP
rs1230511204 1922 dbSNP
rs1275331468 1937 dbSNP
rs1051989081 1938 dbSNP
rs547936124 1939 dbSNP
rs940684318 1949 dbSNP
rs1249721735 1950 dbSNP
rs1361443928 1952 dbSNP
rs1484330945 1955 dbSNP
rs908132953 1957 dbSNP
rs1177390793 1958 dbSNP
rs1443231813 1962 dbSNP
rs1409807490 1972 dbSNP
rs1391255908 1975 dbSNP
rs1421927062 1978 dbSNP
rs922059855 1982 dbSNP
rs752113551 1984 dbSNP
rs1167645397 1985 dbSNP
rs936883281 2009 dbSNP
rs186736096 2010 dbSNP
rs1301969787 2025 dbSNP
rs1403609485 2035 dbSNP
rs978102646 2039 dbSNP
rs767010973 2040 dbSNP
rs1364319052 2045 dbSNP
rs1212756035 2046 dbSNP
rs1293492201 2046 dbSNP
rs971168854 2048 dbSNP
rs1025053567 2051 dbSNP
rs991279541 2052 dbSNP
rs569486620 2066 dbSNP
rs1024045621 2070 dbSNP
rs959462633 2070 dbSNP
rs1009918087 2076 dbSNP
rs1034124699 2078 dbSNP
rs1306774059 2084 dbSNP
rs1032933245 2086 dbSNP
rs1433320936 2086 dbSNP
rs201839399 2086 dbSNP
rs955665883 2086 dbSNP
rs1255928375 2087 dbSNP
rs1175100018 2092 dbSNP
rs1000487841 2093 dbSNP
rs1220181076 2094 dbSNP
rs1318187504 2106 dbSNP
rs889705450 2110 dbSNP
rs1050065759 2122 dbSNP
rs758986758 2124 dbSNP
rs997957435 2126 dbSNP
rs994655011 2128 dbSNP
rs1303997587 2132 dbSNP
rs1428515343 2134 dbSNP
rs1442121248 2143 dbSNP
rs899075151 2147 dbSNP
rs1015291324 2150 dbSNP
rs1368231580 2154 dbSNP
rs1219818643 2156 dbSNP
rs1282764573 2159 dbSNP
rs1173302655 2164 dbSNP
rs1321613700 2166 dbSNP
rs555712512 2168 dbSNP
rs1269133103 2169 dbSNP
rs1466430963 2173 dbSNP
rs1214265590 2177 dbSNP
rs535505896 2179 dbSNP
rs1040409983 2180 dbSNP
rs112120091 2184 dbSNP
rs1266175299 2185 dbSNP
rs890077635 2190 dbSNP
rs1473354968 2191 dbSNP
rs1159495655 2194 dbSNP
rs541915775 2209 dbSNP
rs995897070 2211 dbSNP
rs907832177 2220 dbSNP
rs1049050267 2221 dbSNP
rs1404284079 2223 dbSNP
rs574991586 2226 dbSNP
rs1302606688 2227 dbSNP
rs1343766952 2228 dbSNP
rs900270473 2239 dbSNP
rs147542512 2240 dbSNP
rs927549131 2250 dbSNP
rs1176628742 2252 dbSNP
rs1222352922 2253 dbSNP
rs1292503258 2256 dbSNP
rs936849993 2257 dbSNP
rs1222467575 2274 dbSNP
rs533509898 2280 dbSNP
rs1288922466 2284 dbSNP
rs924207810 2294 dbSNP
rs1182436674 2303 dbSNP
rs1457275057 2311 dbSNP
rs1231887511 2314 dbSNP
rs570648178 2316 dbSNP
rs1468308151 2317 dbSNP
rs1236241460 2324 dbSNP
rs1200346078 2325 dbSNP
rs550535245 2330 dbSNP
rs775044400 2334 dbSNP
rs1414318607 2336 dbSNP
rs1272212988 2342 dbSNP
rs1423890406 2343 dbSNP
rs980292558 2344 dbSNP
rs971525353 2346 dbSNP
rs1431637744 2350 dbSNP
rs917020038 2351 dbSNP
rs1043069204 2355 dbSNP
rs1440323672 2356 dbSNP
rs949671754 2360 dbSNP
rs1312823301 2363 dbSNP
rs1245880597 2378 dbSNP
rs988518471 2378 dbSNP
rs1222657225 2390 dbSNP
rs917883262 2391 dbSNP
rs990856660 2394 dbSNP
rs1435692919 2395 dbSNP
rs1211846602 2397 dbSNP
rs978450091 2398 dbSNP
rs959431964 2399 dbSNP
rs920039203 2401 dbSNP
rs769254257 2413 dbSNP
rs763307702 2423 dbSNP
rs1391871439 2429 dbSNP
rs1028228818 2431 dbSNP
rs530812402 2432 dbSNP
rs116007856 2453 dbSNP
rs541775931 2456 dbSNP
rs1336475505 2458 dbSNP
rs1459646927 2466 dbSNP
rs1452300894 2467 dbSNP
rs1335179683 2468 dbSNP
rs1367910925 2470 dbSNP
rs1369214523 2471 dbSNP
rs770182254 2482 dbSNP
rs7872479 2483 dbSNP
rs1220581222 2487 dbSNP
rs558977033 2490 dbSNP
rs1460598173 2497 dbSNP
rs1180413796 2498 dbSNP
rs1030387165 2500 dbSNP
rs1249690346 2505 dbSNP
rs1192435658 2510 dbSNP
rs930645657 2510 dbSNP
rs1366699890 2511 dbSNP
rs777037794 2512 dbSNP
rs116284865 2513 dbSNP
rs900237701 2515 dbSNP
rs1469502388 2533 dbSNP
rs1489269797 2534 dbSNP
rs1391336149 2548 dbSNP
rs576573411 2555 dbSNP
rs79588054 2564 dbSNP
rs757067595 2567 dbSNP
rs747090049 2570 dbSNP
rs988971985 2577 dbSNP
rs1322342015 2578 dbSNP
rs1221361409 2579 dbSNP
rs544508828 2579 dbSNP
rs902640049 2587 dbSNP
rs1042575894 2589 dbSNP
rs575867983 2593 dbSNP
rs918201779 2605 dbSNP
rs1259504450 2606 dbSNP
rs1370826180 2608 dbSNP
rs1055038418 2609 dbSNP
rs925710082 2612 dbSNP
rs1388843141 2614 dbSNP
rs938048462 2627 dbSNP
rs1414630480 2632 dbSNP
rs555792679 2643 dbSNP
rs1288483614 2646 dbSNP
rs953709496 2649 dbSNP
rs181320411 2652 dbSNP
rs1383382051 2657 dbSNP
rs1165949814 2663 dbSNP
rs1407601067 2666 dbSNP
rs1303209021 2669 dbSNP
rs780419972 2672 dbSNP
rs772479143 2677 dbSNP
rs976600118 2679 dbSNP
rs1376947905 2687 dbSNP
rs961448589 2708 dbSNP
rs965257154 2712 dbSNP
rs1237974763 2718 dbSNP
rs1434654264 2719 dbSNP
rs1358351569 2722 dbSNP
rs907671497 2722 dbSNP
rs758573746 2729 dbSNP
rs1192464216 2740 dbSNP
rs573269440 2751 dbSNP
rs1197376106 2756 dbSNP
rs1254163667 2758 dbSNP
rs1015419882 2762 dbSNP
rs1181479534 2764 dbSNP
rs10964967 2766 dbSNP
rs886551397 2772 dbSNP
rs954768098 2773 dbSNP
rs1216630757 2775 dbSNP
rs1030274761 2786 dbSNP
rs995262353 2792 dbSNP
rs905823732 2793 dbSNP
rs1390510078 2799 dbSNP
rs1304560405 2807 dbSNP
rs1342111199 2812 dbSNP
rs1044675443 2814 dbSNP
rs1314218169 2818 dbSNP
rs1357195214 2819 dbSNP
rs539923278 2825 dbSNP
rs1253167847 2829 dbSNP
rs1235944730 2833 dbSNP
rs1195489510 2834 dbSNP
rs1332022958 2839 dbSNP
rs1446887294 2841 dbSNP
rs896069845 2843 dbSNP
rs1385087650 2846 dbSNP
rs1443360558 2852 dbSNP
rs1053306555 2860 dbSNP
rs1277874356 2865 dbSNP
rs934832621 2879 dbSNP
rs964411891 2883 dbSNP
rs746828584 2893 dbSNP
rs978512425 2894 dbSNP
rs1342542794 2898 dbSNP
rs1000590957 2904 dbSNP
rs1403921757 2905 dbSNP
rs932313325 2918 dbSNP
rs902279523 2923 dbSNP
rs1021525217 2938 dbSNP
rs570882750 2940 dbSNP
rs1380422338 2942 dbSNP
rs534922394 2943 dbSNP
rs550723058 2946 dbSNP
rs143282216 2948 dbSNP
rs749068666 2953 dbSNP
rs1308225913 2954 dbSNP
rs1055344398 2965 dbSNP
rs1462830635 2969 dbSNP
rs938269678 2975 dbSNP
rs115943254 2978 dbSNP
rs755890615 2980 dbSNP
rs1377986141 2982 dbSNP
rs140933086 2986 dbSNP
rs908453744 2989 dbSNP
rs1169615973 2992 dbSNP
rs940076261 2994 dbSNP
rs1167707016 2995 dbSNP
rs983032405 2996 dbSNP
rs908648241 2998 dbSNP
rs1476644586 2999 dbSNP
rs147981014 3019 dbSNP
rs1175411964 3026 dbSNP
rs1403691240 3032 dbSNP
rs549252097 3034 dbSNP
rs148998700 3038 dbSNP
rs528418291 3038 dbSNP
rs758525373 3038 dbSNP
rs1293566117 3042 dbSNP
rs1441307689 3056 dbSNP
rs376694094 3059 dbSNP
rs1224407136 3071 dbSNP
rs781001390 3076 dbSNP
rs1202697011 3078 dbSNP
rs1321926905 3079 dbSNP
rs1218396974 3087 dbSNP
rs970124321 3095 dbSNP
rs1346241226 3096 dbSNP
rs923178647 3097 dbSNP
rs1270467463 3103 dbSNP
rs1480540004 3104 dbSNP
rs116417479 3108 dbSNP
rs1426929220 3113 dbSNP
rs72697315 3114 dbSNP
rs147287298 3121 dbSNP
rs1447454319 3123 dbSNP
rs1344496497 3127 dbSNP
rs1338762775 3134 dbSNP
rs867686158 3134 dbSNP
rs979118445 3143 dbSNP
rs1397719971 3145 dbSNP
rs999448320 3146 dbSNP
rs966851746 3147 dbSNP
rs904651546 3152 dbSNP
rs1169726914 3153 dbSNP
rs1020739168 3155 dbSNP
rs1225787694 3167 dbSNP
rs1014168631 3179 dbSNP
rs1316817028 3180 dbSNP
rs1214322797 3181 dbSNP
rs1463833030 3182 dbSNP
rs1490388338 3183 dbSNP
rs1221113987 3188 dbSNP
rs563263983 3189 dbSNP
rs932456370 3191 dbSNP
rs1170926797 3197 dbSNP
rs1177522648 3197 dbSNP
rs1407043618 3200 dbSNP
rs569509572 3201 dbSNP
rs548171441 3205 dbSNP
rs943678286 3211 dbSNP
rs1033818621 3213 dbSNP
rs1302664803 3225 dbSNP
rs542666333 3227 dbSNP
rs575749730 3227 dbSNP
rs919803406 3231 dbSNP
rs1373136506 3234 dbSNP
rs1443518421 3238 dbSNP
rs189675521 3240 dbSNP
rs1038314892 3241 dbSNP
rs1162980623 3242 dbSNP
rs1221039788 3242 dbSNP
rs1288986657 3242 dbSNP
rs573795619 3242 dbSNP
rs1491403742 3243 dbSNP
rs542530106 3243 dbSNP
rs1197185912 3246 dbSNP
rs1459351993 3247 dbSNP
rs1023045120 3250 dbSNP
rs1444948546 3252 dbSNP
rs1339145043 3253 dbSNP
rs887181380 3257 dbSNP
rs1312243436 3268 dbSNP
rs114493865 3284 dbSNP
rs1214658660 3287 dbSNP
rs1271767415 3291 dbSNP
rs1032343775 3294 dbSNP
rs1205276205 3295 dbSNP
rs999084269 3302 dbSNP
rs904769731 3317 dbSNP
rs1181747719 3323 dbSNP
rs1235789897 3326 dbSNP
rs553379479 3339 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_018847 | 3UTR | UUAGAUGUCUUUUUGUGAUGUUAUAUAAAAUUGUAGAUGACUGUGGUAAAUGUGUAAUUAUGUCCAUUAUGCUUCAAAGUUGAGUUUUCAUCUUUGACUCCAAAAUGUCAGAGGGAGGCCGCUCUAAACUAAAAAUAACGAAAGGUUGCCAAGUAUUAAUACUAGUUACCUCCCUCUUUUCGUAGUUUUUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_018847 | 3UTR | AGACGUAGAAAAAUGUUUAGAUGUCUUUUUGUGAUGUUAUAUAAAAUUGUAGAUGACUGUGGUAAAUGUGUAAUUAUGUCCAUUAUGCUUCAAAGUUGAGUUUUCAUCUUUGACUCCAAAAUGUCAGAGGGAGGCCGCUCUAAACUAAAAAUAACGAAAGGUUGCCAAGUAUUAAUACUAGUUACCUCCCUCUUUUCGUAGUUUUUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_018847 | 3UTR | UUUUGUGAUGUUAUAUAAAAUUGUAGAUGACUGUGGUAAAUGUGUAAUUAUGUCCAUUAUGCUUCAAAGUUGAGUUUUCAUCUUUGACUCCAAAAUGUCAGAGGGAGGCCGCUCUAAACUAAAAAUAACGAAAGGUUGCCAAGUAUUAAUACUAGUUACCUCCCUCUUUUCGUAGUUUUUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_018847 | 3UTR | GGGAGGCCGCUCUAAACUAAAAAUAACGAAAGGUUGCCAAGUAUUAAUACUAGUUACCUCCCUCUUUUCGUAGUUUUUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_018847 | 3UTR | GUUUAGAUGUCUUUUUGUGAUGUUAUAUAAAAUUGUAGAUGACUGUGGUAAAUGUGUAAUUAUGUCCAUUAUGCUUCAAAGUUGAGUUUUCAUCUUUGACUCCAAAAUGUCAGAGGGAGGCCGCUCUAAACUAAAAAUAACGAAAGGUUGCCAAGUAUUAAUACUAGUUACCUCCCUCUUUUCGUAGUUUUUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000359039.4 | 3UTR | UGUCAGAGGGAGGCCGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.563 2.1e-3 -0.625 5.5e-4 24 Click to see details
GSE28260 Renal cortex and medulla 0.642 9.0e-3 0.516 3.6e-2 13 Click to see details
GSE32688 Pancreatic cancer -0.396 1.2e-2 -0.053 3.9e-1 32 Click to see details
GSE42095 Differentiated embryonic stem cells -0.463 1.3e-2 -0.436 1.9e-2 23 Click to see details
GSE26953 Aortic valvular endothelial cells -0.239 1.3e-1 -0.182 2.0e-1 24 Click to see details
GSE38226 Liver fibrosis 0.086 3.6e-1 0.003 4.9e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.02 4.6e-1 0.089 3.4e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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