miRTarBase - #MIRT616950


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pre-miRNA Information
pre-miRNA hsa-mir-1231   
Genomic Coordinates chr1: 201808611 - 201808702
Synonyms MIRN1231, hsa-mir-1231, MIR1231
Description Homo sapiens miR-1231 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1231
Sequence 5| GUGUCUGGGCGGACAGCUGC |24
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN25212119 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs768024461 3 dbSNP
rs116338160 9 dbSNP
rs112032363 10 dbSNP
rs544709517 11 dbSNP
Putative Targets

Gene Information
Gene Symbol MAPKAPK2   
Synonyms MAPKAP-K2, MK-2, MK2
Description mitogen-activated protein kinase-activated protein kinase 2
Transcript NM_004759   
Other Transcripts NM_032960   
Expression
Putative miRNA Targets on MAPKAPK2
3'UTR of MAPKAPK2
(miRNA target sites are highlighted)		 
>MAPKAPK2|NM_004759|3'UTR
   1 GCAGAGGATTCTGTGTTCCTGTCCAAACTCAGTGCTGTTTCTTAGAATCCTTTTATTCCCTGGGTCTCTAATGGGACCTT
  81 AAAGACCATCTGGTATCATCTTCTCATTTTGCAGAAGAGAAACTGAGGCCCAGAGGCGGAGGGCAGTCTGCTCAAGGTCA
 161 CGCAGCTGGTGACTGGTTGGGGCAGACCGGACCCAGGTTTCCTGACTCCTGGCCCAAGTCTCTTCCTCCTATCCTGCGGG
 241 ATCACTGGGGGGCTCTCAGGGAACAGCAGCAGTGCCATAGCCAGGCTCTCTGCTGCCCAGCGCTGGGGTGAGGCTGCCGT
 321 TGTCAGCGTGGACCACTAACCAGCCCGTCTTCTCTCTCTGCTCCCACCCCTGCCGCCCTCACCCTGCCCTTGTTGTCTCT
 401 GTCTCTCACGTCTCTCTTCTGCTGTCTCTCCTACCTGTCTTCTGGCTCTCTCTGTACCCTTCCTGGTGCTGCCGTGCCCC
 481 CAGGAGGAGATGACCAGTGCCTTGGCCACAATGCGCGTTGACTACGAGCAGATCAAGATAAAAAAGATTGAAGATGCATC
 561 CAACCCTCTGCTGCTGAAGAGGCGGAAGAAAGCTCGGGCCCTGGAGGCTGCGGCTCTGGCCCACTGAGCCACCGCGCCCT
 641 CCTGCCCACGGGAGGACAAGCAATAACTCTCTACAGGAATATATTTTTTAAACGAAGAGACAGAACTGTCCACATCTGCC
 721 TCCTCTCCTCCTCAGCTGCATGGAGCCTGGAACTGCATCAGTGACTGAATTCTGCCTTGGTTCTGGCCACCCCAGAGTGG
 801 GAGAGGCTGGGAGGTTGGGAGGCTGTGGAGAGAAGTGAGCAAGGTGCTCTTGAACCTGTGCTCATTTTGCAATTTTATCA
 881 GTAATTTGACTTAGAGTTTTTACGAAACCTCTTTTGTTGTCCTTGCCCCACTCCTCTCCACCAGACGCCTTCCTCTCTGG
 961 ATACTGCAAAGGCTTGTGGTTTGTTAGAGGGTATTTGTGGAAACTGTCATAGGGATTGTCCCTGTGTTGTCCCATCTGCC
1041 CTCCCTGTTTCTCCACAACAGCCTGGGGTTGTCCCCGCTGGCTCACGCGTTCTGGGAGCTCAAGGCCACCTTGGAGGAGG
1121 ATGCCACGCACTTCCTCTCTCGGAGCCCTCAGACATCTCCAGTGTGCCAGACAAATAGGAGTGAGTGTATGTGTGTGTGT
1201 GTGTGTGTGTGTGTGCACACGTGTGTATGAGTGCGCAGATCTGTGCCTGGGATCGTGCATTTGAGGGGCCAGGGGCAGGC
1281 AGGGCTGCAGAGGGAGACGGCCCTGCTGGGGCTTAGGAACCTTCTCCCTTCTTGGGTCTGCCCTGCCCATACTGAGCCTG
1361 CCAAAGTGCCTGGGAAGCCCACCCAGATTCTGAAACAGGCCCTCTGTGGCCTGTCTCTATTAGCTGGGTTCCGGGAGGCA
1441 GAGAGGAGTGACCGGGCACTGGCACTGCGATCAGGAAGACTGGACCCCCAGCCCCCAGGGCCCCCCTCCCCCCACTTAGT
1521 GCTGGTCCTAGGTCCTCTGAGGCACTCATCTACTGAATGACCTCTCTACTTCCCCTTCTTGCCATTATTAACCCATTTTT
1601 GTTTATTTTCCTTAAATTTTTAGCCATTTCTCCATGGGCCACCGCCCAGCTCATGTAGGTGAGCCTGGGCAGCTTCTGTT
1681 GGCAGAGCTTTTGCATTTCCTGTGTTTGTCCTGGGTTCTGGGGCATCAGCCAGCTACCCCTTGTGGGCAAAGGCAGGGCC
1761 ACTTTTGAAGTCTTCCCTCAGATTTCCATTGTGTGGCCTGGTGGGTCAGGGGGAGTCTTTGCACCAAAGATGTCCTGACT
1841 TTGCCCCCTTGCCCATCAGCCATTTGCCATCACCCCAAACAACTCAGCTTCGGGGCCGGTGAGGGGAGGGGCCTCCCCCA
1921 GCACAGATGAGGAGCAGCTGGGGTAGGCTGTCTGTGCCATGGCCCCCCACTCCCCCTTCCCTTGGAGGGAGAGGTGGCAG
2001 GAATACTTCACCTTTCCTCTCCCTCAGGGGCAGGTGGTGGAGGGGCGCCCAGGGTCGTCTTTGTGTATGGGGGAAGGCGC
2081 TGGGTGCCTGCAGCGCCTCCCTTGTCTCAGATGGTGTGTCCAGCACTCGATTGTTGTAAACTGTTGTTTTGTATGAGCGA
2161 AATTGTCTTTACTAAACAGATTTAATAGTTGAGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgucGACAGGCGGGUCUGUg 5'
              | || :| ||||||| 
Target 5' tctcCAGTGTG-CCAGACAa 3'
 1156 - 1174 147.00 -14.50
2 
miRNA  3' cgucGACAGGCGGGUCUGUg 5'
              || |||  ||||||: 
Target 5' actcCTCTCC-ACCAGACGc 3'
 930 - 948 135.00 -18.10
3 
miRNA  3' cguCGACAGGCGGGUCUGUg 5'
             ||  ||  |||| ||| 
Target 5' tttGCCATCACCCCAAACAa 3'
 1863 - 1882 121.00 -9.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN509331 11 COSMIC
COSN30113825 46 COSMIC
COSN30451286 50 COSMIC
COSN30477195 51 COSMIC
COSN30489297 51 COSMIC
COSN19730044 61 COSMIC
COSN30143540 78 COSMIC
COSN30139625 105 COSMIC
COSN31526949 120 COSMIC
COSN30141802 152 COSMIC
COSN30537863 163 COSMIC
COSN31492586 290 COSMIC
COSN30529694 303 COSMIC
COSN8336861 319 COSMIC
COSN30114778 348 COSMIC
COSN31508654 348 COSMIC
COSN27310595 357 COSMIC
COSN31508194 359 COSMIC
COSN30534083 367 COSMIC
COSN30187949 372 COSMIC
COSN30537369 396 COSMIC
COSN28628086 404 COSMIC
COSN24308670 406 COSMIC
COSN28627590 408 COSMIC
COSN2528888 429 COSMIC
COSN30128276 457 COSMIC
COSN26678516 472 COSMIC
COSM5353270 475 COSMIC
COSM8508223 479 COSMIC
COSM6248976 484 COSMIC
COSM5881621 501 COSMIC
COSM5353194 506 COSMIC
COSM1257333 516 COSMIC
COSM903001 518 COSMIC
COSM373753 527 COSMIC
COSM8243349 528 COSMIC
COSM1748118 532 COSMIC
COSM325764 532 COSMIC
COSM1185717 557 COSMIC
COSM9335365 567 COSMIC
COSM6708069 572 COSMIC
COSM3664707 586 COSMIC
COSM4143285 596 COSMIC
COSM4143286 600 COSMIC
COSM9161741 613 COSMIC
COSM9108475 614 COSMIC
COSM7662114 623 COSMIC
COSN30107274 634 COSMIC
COSN30166238 635 COSMIC
COSN31500959 635 COSMIC
COSN31569880 636 COSMIC
COSN509332 650 COSMIC
COSN31542002 669 COSMIC
COSN31612778 694 COSMIC
COSN31613596 707 COSMIC
COSN30171111 717 COSMIC
COSN1096751 758 COSMIC
COSN22671392 809 COSMIC
COSN5364083 928 COSMIC
COSN32058189 1087 COSMIC
COSN29237468 1128 COSMIC
COSN32065073 1163 COSMIC
COSN20095887 1213 COSMIC
COSN20095886 1215 COSMIC
COSN17181591 1604 COSMIC
COSN31570832 1619 COSMIC
COSN7199516 1645 COSMIC
COSN30172481 1728 COSMIC
COSN31550895 1853 COSMIC
COSN31490589 1892 COSMIC
COSN28653033 1898 COSMIC
COSN31594719 1970 COSMIC
COSN31485985 2011 COSMIC
COSN31490594 2017 COSMIC
COSN9057513 2058 COSMIC
COSN7199517 2096 COSMIC
rs3813961 364 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs374876954 8 dbSNP
rs1323934971 11 dbSNP
rs1264789366 20 dbSNP
rs539375813 28 dbSNP
rs782462168 29 dbSNP
rs782592157 38 dbSNP
rs781837159 39 dbSNP
rs1321667424 55 dbSNP
rs1300922619 70 dbSNP
rs77672930 72 dbSNP
rs956925298 78 dbSNP
rs1375667212 90 dbSNP
rs1296912549 99 dbSNP
rs115818180 100 dbSNP
rs1407220083 101 dbSNP
rs782232854 112 dbSNP
rs1179036002 118 dbSNP
rs575495722 122 dbSNP
rs367715721 125 dbSNP
rs1428148345 129 dbSNP
rs970649202 138 dbSNP
rs1420313889 139 dbSNP
rs541257293 146 dbSNP
rs980668385 154 dbSNP
rs1461719324 156 dbSNP
rs1244967806 162 dbSNP
rs1201526536 163 dbSNP
rs1460745640 167 dbSNP
rs747688630 177 dbSNP
rs78224104 183 dbSNP
rs1240064983 184 dbSNP
rs1318756473 187 dbSNP
rs1304969374 189 dbSNP
rs141688005 190 dbSNP
rs1339338518 195 dbSNP
rs963198161 197 dbSNP
rs1450880478 198 dbSNP
rs1401984467 201 dbSNP
rs1289038281 202 dbSNP
rs558762767 204 dbSNP
rs1361488421 207 dbSNP
rs1157732552 216 dbSNP
rs187652025 223 dbSNP
rs1181723485 229 dbSNP
rs928971519 232 dbSNP
rs1262193009 234 dbSNP
rs987125984 239 dbSNP
rs1486972597 243 dbSNP
rs1259254106 245 dbSNP
rs1215968288 247 dbSNP
rs912824580 248 dbSNP
rs373125932 253 dbSNP
rs1317736801 264 dbSNP
rs1244452768 266 dbSNP
rs1340186786 268 dbSNP
rs147064277 269 dbSNP
rs1296748276 275 dbSNP
rs1384346879 276 dbSNP
rs1382312784 285 dbSNP
rs1297254886 286 dbSNP
rs1424711616 287 dbSNP
rs1366929248 293 dbSNP
rs1161541104 296 dbSNP
rs116286581 302 dbSNP
rs116280694 303 dbSNP
rs1195054172 305 dbSNP
rs1426577376 307 dbSNP
rs1259885843 319 dbSNP
rs900050731 320 dbSNP
rs1490520636 323 dbSNP
rs1294061549 328 dbSNP
rs797029407 329 dbSNP
rs1356255082 332 dbSNP
rs868962824 347 dbSNP
rs1054289508 348 dbSNP
rs892524016 349 dbSNP
rs1010003670 352 dbSNP
rs1025000952 355 dbSNP
rs781996049 362 dbSNP
rs3813961 364 dbSNP
rs1300746431 368 dbSNP
rs1033591656 375 dbSNP
rs548666544 376 dbSNP
rs1169627036 377 dbSNP
rs963208302 390 dbSNP
rs1460248960 398 dbSNP
rs973197250 399 dbSNP
rs1026494792 410 dbSNP
rs950472315 411 dbSNP
rs1271403124 424 dbSNP
rs987607037 425 dbSNP
rs1197351372 428 dbSNP
rs782498421 436 dbSNP
rs782642650 437 dbSNP
rs568282013 449 dbSNP
rs782183168 453 dbSNP
rs782277040 455 dbSNP
rs1198113200 457 dbSNP
rs1337797515 462 dbSNP
rs911590924 463 dbSNP
rs782418133 469 dbSNP
rs782583951 474 dbSNP
rs145221925 475 dbSNP
rs550900907 477 dbSNP
rs781949358 478 dbSNP
rs921483174 482 dbSNP
rs55894011 506 dbSNP
rs782118884 509 dbSNP
rs372815549 517 dbSNP
rs782022011 518 dbSNP
rs782169776 526 dbSNP
rs782704000 527 dbSNP
rs892611562 546 dbSNP
rs1337144318 549 dbSNP
rs781818804 555 dbSNP
rs782095181 562 dbSNP
rs782775477 565 dbSNP
rs781865671 575 dbSNP
rs782691475 584 dbSNP
rs782530956 592 dbSNP
rs782678368 593 dbSNP
rs191175287 597 dbSNP
rs782469293 602 dbSNP
rs782600274 605 dbSNP
rs1171083058 607 dbSNP
rs782232686 612 dbSNP
rs201580623 613 dbSNP
rs782652551 615 dbSNP
rs782282911 617 dbSNP
rs781933066 625 dbSNP
rs545967385 634 dbSNP
rs1033603088 635 dbSNP
rs112632608 636 dbSNP
rs374144301 637 dbSNP
rs1350702381 638 dbSNP
rs1026170326 641 dbSNP
rs782422114 641 dbSNP
rs782780403 647 dbSNP
rs950592569 648 dbSNP
rs782031747 650 dbSNP
rs377226143 651 dbSNP
rs782021227 656 dbSNP
rs781828835 657 dbSNP
rs782486566 659 dbSNP
rs782783799 661 dbSNP
rs964356003 664 dbSNP
rs781869590 668 dbSNP
rs1332384261 671 dbSNP
rs57614552 675 dbSNP
rs782687313 676 dbSNP
rs574695170 680 dbSNP
rs1437964330 682 dbSNP
rs1380202227 683 dbSNP
rs1184793679 684 dbSNP
rs1446780828 686 dbSNP
rs543569251 687 dbSNP
rs1236107116 688 dbSNP
rs373643187 694 dbSNP
rs1447215999 695 dbSNP
rs143218260 707 dbSNP
rs545910954 712 dbSNP
rs914111579 716 dbSNP
rs1202833242 729 dbSNP
rs1352396235 730 dbSNP
rs776501857 735 dbSNP
rs1315601232 741 dbSNP
rs1248113213 747 dbSNP
rs945530930 748 dbSNP
rs1046476650 758 dbSNP
rs927998988 765 dbSNP
rs1283381960 774 dbSNP
rs559712343 778 dbSNP
rs1431286387 781 dbSNP
rs938006308 784 dbSNP
rs1320584426 789 dbSNP
rs1417904687 794 dbSNP
rs1360015981 798 dbSNP
rs1164719118 809 dbSNP
rs1427124834 812 dbSNP
rs1412351696 815 dbSNP
rs1055105855 816 dbSNP
rs899145367 818 dbSNP
rs782781155 819 dbSNP
rs1181628902 823 dbSNP
rs1475974042 833 dbSNP
rs1243462837 844 dbSNP
rs1191108928 845 dbSNP
rs1487649237 865 dbSNP
rs1291891405 867 dbSNP
rs994794635 868 dbSNP
rs528464908 873 dbSNP
rs886277192 875 dbSNP
rs1289127232 876 dbSNP
rs1214915098 880 dbSNP
rs542344258 887 dbSNP
rs1272104950 893 dbSNP
rs182195171 902 dbSNP
rs1339858884 903 dbSNP
rs964407710 904 dbSNP
rs1348624387 914 dbSNP
rs1164742964 917 dbSNP
rs1410845318 919 dbSNP
rs1422127935 930 dbSNP
rs550751494 944 dbSNP
rs1032670549 947 dbSNP
rs576476194 948 dbSNP
rs1200940318 951 dbSNP
rs1487245128 954 dbSNP
rs782137999 962 dbSNP
rs781859813 964 dbSNP
rs957256241 966 dbSNP
rs570686602 973 dbSNP
rs1308985957 992 dbSNP
rs78903210 994 dbSNP
rs1255933567 1004 dbSNP
rs1216958002 1012 dbSNP
rs533241822 1015 dbSNP
rs1317508573 1025 dbSNP
rs914098356 1027 dbSNP
rs1220986883 1035 dbSNP
rs1130514 1039 dbSNP
rs1365625345 1044 dbSNP
rs1293411091 1054 dbSNP
rs782494545 1058 dbSNP
rs1329719305 1061 dbSNP
rs1465484304 1067 dbSNP
rs1429521925 1070 dbSNP
rs372546598 1077 dbSNP
rs982246515 1078 dbSNP
rs928051253 1087 dbSNP
rs1423883673 1088 dbSNP
rs1177653566 1089 dbSNP
rs546546506 1090 dbSNP
rs566485516 1093 dbSNP
rs1461635944 1094 dbSNP
rs1263947591 1096 dbSNP
rs1212543587 1126 dbSNP
rs148386379 1129 dbSNP
rs1300688848 1135 dbSNP
rs1224473887 1140 dbSNP
rs61078756 1142 dbSNP
rs781814733 1143 dbSNP
rs1446463338 1146 dbSNP
rs1407335591 1147 dbSNP
rs1338238159 1149 dbSNP
rs1464240979 1154 dbSNP
rs1358004551 1155 dbSNP
rs759205905 1161 dbSNP
rs568603764 1174 dbSNP
rs782196605 1177 dbSNP
rs1378370964 1181 dbSNP
rs1177971926 1185 dbSNP
rs1202331474 1185 dbSNP
rs1244763607 1185 dbSNP
rs1482399168 1186 dbSNP
rs879999472 1186 dbSNP
rs1216556196 1188 dbSNP
rs886327196 1189 dbSNP
rs10552685 1190 dbSNP
rs10552736 1190 dbSNP
rs1157917874 1190 dbSNP
rs1355995064 1190 dbSNP
rs1358099689 1190 dbSNP
rs201361332 1190 dbSNP
rs5780359 1190 dbSNP
rs782092343 1190 dbSNP
rs879959460 1190 dbSNP
rs879973526 1190 dbSNP
rs879980181 1190 dbSNP
rs879981608 1190 dbSNP
rs1008750733 1191 dbSNP
rs1387088714 1198 dbSNP
rs1185130431 1202 dbSNP
rs1423074553 1205 dbSNP
rs868909987 1206 dbSNP
rs1255690315 1208 dbSNP
rs1489282368 1209 dbSNP
rs1040209960 1212 dbSNP
rs1216437188 1212 dbSNP
rs900333188 1213 dbSNP
rs1267814275 1214 dbSNP
rs1321529146 1215 dbSNP
rs80008420 1215 dbSNP
rs1032722993 1216 dbSNP
rs1401479554 1217 dbSNP
rs1337685304 1218 dbSNP
rs957060839 1221 dbSNP
rs1392760937 1222 dbSNP
rs1161428318 1228 dbSNP
rs1010281865 1232 dbSNP
rs1021218547 1235 dbSNP
rs868965584 1236 dbSNP
rs1478926248 1237 dbSNP
rs982344229 1239 dbSNP
rs1193022362 1247 dbSNP
rs1035216342 1248 dbSNP
rs1270045602 1255 dbSNP
rs959519924 1256 dbSNP
rs1252261707 1269 dbSNP
rs557515668 1274 dbSNP
rs868986528 1283 dbSNP
rs1315673822 1299 dbSNP
rs1277237486 1300 dbSNP
rs920641860 1304 dbSNP
rs577331374 1309 dbSNP
rs3189439 1310 dbSNP
rs1386150954 1325 dbSNP
rs1396860564 1341 dbSNP
rs564136849 1342 dbSNP
rs1421727195 1351 dbSNP
rs944648737 1352 dbSNP
rs1478369122 1374 dbSNP
rs1379461519 1379 dbSNP
rs1197291956 1382 dbSNP
rs1433113051 1391 dbSNP
rs1251944949 1397 dbSNP
rs1040258651 1400 dbSNP
rs1456744196 1402 dbSNP
rs573281411 1418 dbSNP
rs1203926580 1420 dbSNP
rs1346430294 1425 dbSNP
rs377728087 1426 dbSNP
rs566635540 1426 dbSNP
rs542233652 1433 dbSNP
rs1336265043 1434 dbSNP
rs931774421 1439 dbSNP
rs1444259165 1445 dbSNP
rs1054143122 1450 dbSNP
rs11809485 1452 dbSNP
rs562213709 1454 dbSNP
rs1404706841 1455 dbSNP
rs1170885060 1460 dbSNP
rs1477770553 1461 dbSNP
rs1381444213 1468 dbSNP
rs575789058 1469 dbSNP
rs1009925223 1470 dbSNP
rs1187726586 1481 dbSNP
rs1443780778 1485 dbSNP
rs1020395348 1486 dbSNP
rs41309625 1487 dbSNP
rs544115789 1489 dbSNP
rs1288012589 1493 dbSNP
rs41303301 1494 dbSNP
rs41303299 1495 dbSNP
rs1237887600 1501 dbSNP
rs1003831824 1503 dbSNP
rs1315468463 1514 dbSNP
rs1332493555 1515 dbSNP
rs1413942899 1520 dbSNP
rs879952647 1524 dbSNP
rs1361269268 1536 dbSNP
rs1160911213 1547 dbSNP
rs1418409104 1548 dbSNP
rs1035268970 1552 dbSNP
rs1380294257 1556 dbSNP
rs1164184904 1558 dbSNP
rs959536087 1563 dbSNP
rs782369886 1564 dbSNP
rs1027756883 1565 dbSNP
rs952250528 1570 dbSNP
rs983541873 1575 dbSNP
rs907899205 1593 dbSNP
rs782615944 1594 dbSNP
rs564324306 1608 dbSNP
rs1229792158 1611 dbSNP
rs944704888 1614 dbSNP
rs975972119 1626 dbSNP
rs1447587151 1636 dbSNP
rs532956378 1640 dbSNP
rs1300107982 1642 dbSNP
rs931831693 1643 dbSNP
rs528549640 1644 dbSNP
rs1054674404 1645 dbSNP
rs892953577 1650 dbSNP
rs1412095900 1652 dbSNP
rs1162210260 1653 dbSNP
rs545108332 1654 dbSNP
rs1477941740 1668 dbSNP
rs188087241 1671 dbSNP
rs1190853463 1672 dbSNP
rs1041459756 1673 dbSNP
rs906902527 1679 dbSNP
rs1002500828 1689 dbSNP
rs1223712829 1701 dbSNP
rs1035283840 1712 dbSNP
rs1449594790 1720 dbSNP
rs1288881380 1741 dbSNP
rs1318850762 1748 dbSNP
rs1280387728 1757 dbSNP
rs1216841060 1775 dbSNP
rs895376304 1783 dbSNP
rs1294572822 1789 dbSNP
rs1439227394 1792 dbSNP
rs1323298172 1794 dbSNP
rs368158361 1798 dbSNP
rs528897868 1804 dbSNP
rs1168139140 1816 dbSNP
rs1477184071 1817 dbSNP
rs1425272101 1823 dbSNP
rs1192777720 1832 dbSNP
rs548548024 1845 dbSNP
rs145846730 1856 dbSNP
rs537962148 1859 dbSNP
rs1028265341 1865 dbSNP
rs1199014673 1870 dbSNP
rs1458956076 1874 dbSNP
rs1260191884 1882 dbSNP
rs1197009371 1891 dbSNP
rs541624540 1892 dbSNP
rs1005415207 1893 dbSNP
rs781922049 1896 dbSNP
rs117368663 1898 dbSNP
rs1366088127 1899 dbSNP
rs1303370043 1904 dbSNP
rs976029299 1905 dbSNP
rs1379609076 1910 dbSNP
rs1328803125 1914 dbSNP
rs1464780119 1918 dbSNP
rs921872819 1919 dbSNP
rs1412306270 1929 dbSNP
rs41304109 1929 dbSNP
rs1424334962 1935 dbSNP
rs1179211164 1939 dbSNP
rs1441263528 1942 dbSNP
rs1236141653 1950 dbSNP
rs1177848497 1951 dbSNP
rs1480422040 1952 dbSNP
rs1130528 1953 dbSNP
rs953321312 1957 dbSNP
rs990071370 1958 dbSNP
rs914425077 1959 dbSNP
rs945898609 1960 dbSNP
rs1212289720 1963 dbSNP
rs1310545466 1964 dbSNP
rs1280178558 1969 dbSNP
rs1241519366 1973 dbSNP
rs1379496857 1976 dbSNP
rs539601830 1982 dbSNP
rs1041861272 1986 dbSNP
rs553667852 1989 dbSNP
rs1307532177 1992 dbSNP
rs1391240917 1994 dbSNP
rs938346140 1997 dbSNP
rs1304271055 1998 dbSNP
rs1445123496 2007 dbSNP
rs1055491366 2012 dbSNP
rs894131815 2013 dbSNP
rs1159118656 2018 dbSNP
rs573572831 2020 dbSNP
rs1049313952 2028 dbSNP
rs1424216312 2030 dbSNP
rs535882368 2031 dbSNP
rs1183836340 2034 dbSNP
rs555785277 2035 dbSNP
rs1256898339 2038 dbSNP
rs1217529124 2042 dbSNP
rs7868 2047 dbSNP
rs544717587 2052 dbSNP
rs782002135 2057 dbSNP
rs782117357 2058 dbSNP
rs1028981041 2066 dbSNP
rs1322732660 2078 dbSNP
rs1314372690 2079 dbSNP
rs953373540 2080 dbSNP
rs564378852 2087 dbSNP
rs1354500460 2088 dbSNP
rs577777466 2089 dbSNP
rs1298260565 2095 dbSNP
rs990513645 2096 dbSNP
rs1358510557 2102 dbSNP
rs782750541 2104 dbSNP
rs540046233 2107 dbSNP
rs1369988218 2122 dbSNP
rs1167095107 2127 dbSNP
rs977258515 2130 dbSNP
rs1194454537 2136 dbSNP
rs1489337063 2137 dbSNP
rs1261607278 2139 dbSNP
rs1205084846 2142 dbSNP
rs1488978505 2144 dbSNP
rs928433726 2148 dbSNP
rs150537209 2159 dbSNP
rs560062836 2160 dbSNP
rs1278488592 2168 dbSNP
rs1219890069 2173 dbSNP
rs1337802661 2177 dbSNP
rs1294693491 2178 dbSNP
rs1387279560 2178 dbSNP
rs1392872677 2186 dbSNP
rs1291562590 2190 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgucgacaggcgGGUCUGUg 5'
                      ||||||| 
Target 5' ---------gugCCAGACAa 3'
 		1 - 11
Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000294981.4 | 3UTR | AAUAGGAGUGAGUGUAUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000294981.4 | 3UTR | AAUAGGAGUGAGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000294981.4 | 3UTR | AAUAGGAGUGAGUGUAUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000294981.4 | 3UTR | AAUAGGAGUGAGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000294981.4 | 3UTR | AAUAGGAGUGAGUGUAUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.43 1.8e-2 -0.407 2.4e-2 24 Click to see details
GSE17498 Multiple myeloma 0.258 5.4e-2 0.320 2.2e-2 40 Click to see details
GSE19350 CNS germ cell tumors 0.346 1.4e-1 0.568 2.7e-2 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.223 1.5e-1 -0.159 2.3e-1 23 Click to see details
GSE21687 Ependynoma primary tumors 0.078 2.7e-1 0.087 2.5e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.124 2.8e-1 -0.262 1.0e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.137 2.8e-1 0.159 2.5e-1 20 Click to see details
GSE32688 Pancreatic cancer -0.102 2.9e-1 -0.005 4.9e-1 32 Click to see details
GSE28260 Renal cortex and medulla -0.107 3.6e-1 -0.082 3.9e-1 13 Click to see details
GSE26953 Aortic valvular endothelial cells -0.074 3.7e-1 -0.198 1.8e-1 24 Click to see details
GSE38226 Liver fibrosis 0.035 4.4e-1 0.055 4.1e-1 21 Click to see details
GSE38226 Liver fibrosis 0.035 4.4e-1 0.055 4.1e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
37 hsa-miR-1231 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT075228 PHF13 PHD finger protein 13 2 6
MIRT266936 HDGF heparin binding growth factor 2 6
MIRT441394 SOX5 SRY-box 5 2 2
MIRT446329 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 2 2
MIRT446438 THYN1 thymocyte nuclear protein 1 2 2
MIRT482781 STIM1 stromal interaction molecule 1 2 2
MIRT497714 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT500907 STARD13 StAR related lipid transfer domain containing 13 2 2
MIRT503251 KIF18B kinesin family member 18B 2 2
MIRT504750 TEP1 telomerase associated protein 1 2 4
MIRT512158 CD164 CD164 molecule 2 6
MIRT518043 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 4
MIRT526038 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT529828 ARGFX arginine-fifty homeobox 2 2
MIRT531808 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT533139 WNT10A Wnt family member 10A 2 2
MIRT538612 CCT5 chaperonin containing TCP1 subunit 5 2 4
MIRT555617 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT561705 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT562301 GINM1 glycoprotein integral membrane 1 2 2
MIRT566732 MSH6 mutS homolog 6 2 2
MIRT569369 IMPG1 interphotoreceptor matrix proteoglycan 1 2 2
MIRT572314 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT574602 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT612023 FOXF2 forkhead box F2 2 2
MIRT616950 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2 2
MIRT624175 DERL2 derlin 2 2 2
MIRT647634 FAIM2 Fas apoptotic inhibitory molecule 2 2 2
MIRT659393 CORO2A coronin 2A 2 2
MIRT659955 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT684001 FOLR1 folate receptor 1 2 2
MIRT688143 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT688609 CYBRD1 cytochrome b reductase 1 2 2
MIRT693583 SLC39A1 solute carrier family 39 member 1 2 2
MIRT699922 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT712961 PET117 PET117 homolog 2 2
MIRT723950 TMEM184A transmembrane protein 184A 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1231 Cisplatin 5460033 NSC119875 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-miR-1231 Aromatase Inhibitor sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-1231 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-1231 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-1231 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-1231 Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-1231 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1231 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-1231 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-1231 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-mir-1231 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1231 Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-mir-1231 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-1231 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-1231 Cisplatin 5460033 NSC119875 approved resistant cell line (KYSE)
hsa-mir-1231 Fluorouracil 3385 NSC19893 approved sensitive cell line (KYSE)
hsa-mir-1231 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-1231 Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1231 Paclitaxel 36314 NSC125973 approved resistant cell line (HS578T)
hsa-miR-1231 Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1231 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-1231 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1231 Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1231 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1231 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-1231 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-1231 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-1231 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-1231 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1231 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-1231 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1231 Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)
hsa-miR-1231 Cisplatin 5460033 NSC119875 approved resistant cell line (OVCAR3)

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