pre-miRNA Information
pre-miRNA hsa-mir-6818   
Genomic Coordinates chr22: 30007049 - 30007113
Description Homo sapiens miR-6818 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6818-3p
Sequence 44| UUGUCUCUUGUUCCUCACACAG |65
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1325627700 2 dbSNP
rs750902684 3 dbSNP
rs756542190 6 dbSNP
rs1365035732 17 dbSNP
Putative Targets

Gene Information
Gene Symbol KANK2   
Synonyms ANKRD25, MXRA3, PPKWH, SIP
Description KN motif and ankyrin repeat domains 2
Transcript NM_001136191   
Other Transcripts NM_015493   
Expression
Putative miRNA Targets on KANK2
3'UTR of KANK2
(miRNA target sites are highlighted)
>KANK2|NM_001136191|3'UTR
   1 CCGTGAGGGAGGCGGGGACCAGCCAGACCGGGAGCAAACCGTCCCTTGTCCCCGTCTCCTCCCTGTTCCCGTTCCTCCCT
  81 GGCCCACCCCACTCACACTCCCCAAGGCCCACGGCTCAAAGGCAAGCGAGCTCTCCCTCTGCTTCCCTGGGGGAGCCCCG
 161 ACGGCCACAGGACTCCAGCTCCAAGTGGGTTTTCTTGGCTCCCCTGTTCAAAGTGGCCACAGCGCAGACCGAAGCAAAAT
 241 TCTTGTATACATTGGCGCCAGGGCTGATGCTGGGGTGTGGGTTTTATGAAGAACATTGAGAACAATCAGCTGGTAATTAT
 321 GGATGGAGGAAGAGGGAGAGGAAAAAAATATTGTATTTTTGAATCATTGTTGCAGGAGGGGGTGGGAATCTTAGGATTTG
 401 TTGCCAGATTTGAAAGTCACTGGAACTTGCATATTTTCATTTTAATCCTAAGTGTTATTACGCACCAGTTGGGGTTCACC
 481 CTTCATCCCCCACATTTAATTGTCTGATATAGAATAGTGTTGTGTCCACTGCCCCGCTAGACGGCTTTCTTAGGGGAATT
 561 TTCTTCTGGTTGTTTCACAAGACAGATTCTGTCCTTGTCACCCGGGACAGAAAACTCAGTCTTTTCACCCTCATTCAGAT
 641 GAAGGGACTCAGGACAGGCTCTGTGACTTACAGGGACCCAATCAATTCACAATGAGAAATTACCGGCCAGGCGTGGTGAC
 721 TCACGTCTGTAATCCCAGCACTTTGGGAGGGCAAGGCAAGAGCTTGAGCTTGAGCCTAGACGTTAAAGACCAGCCTGGGC
 801 AACACAGCAAGACCCATCTCTACAAGAAATTTAAAAACTAGCCAGGCGTGGTGGTGCGCGCCTGTAGTCCCAGCTACTTG
 881 GGAGGCTGAGCCCTGGAGGTCGAGGCTACAGTGAGCTATGATCACACCATTGCACTTCAGCCTGGGCGACACAGCGAGAC
 961 CCTGTCTCAAGAAAGAAAAGAAAAAGAGACAAATTACCCAGAAACCCCTCCCTTCCCCACATGGAGGCCTTGGCAAATGT
1041 TAATTTTCCTAGAAAATCCTTCAGACCTGAAGACGCAGGAAAAGAATCTGGCTCTCAGGGTGGCTTCTGCGTCCCCGCCG
1121 CCAGGCCCCAGACTATGGTCACAGGGCCGTCCTGTTCCTCCCCGGGACTCCAGAATTTCTCTCCTCAAAGGAAAGAAAAC
1201 AGGGCATGCGCTTGTTGGCAAAACGCAGGGCCGGCTCCCAAAAACCCCATGTGTGTACGATTAAAAGTTGGCCGTCCCCA
1281 GGCCTCCCAGCGCAAACTTAAAGAGACAGGGCTTTGCTGAAAACCAAACATGGGCCAGCTGGGCTTTTTAACAACCTAGA
1361 GACTTTCCGGAGCTGCCTGGAACAGAGCCTGCGGGAAACGGGGCTTGCCAGAGACACTCACAGTTTCCTTCATGGCCTGT
1441 TTTGGTCCCCTAAGAATCTCCACATCATTGTCTTTCTTGTGCCTTTTCCTTGGTGAGCAACAGAAAGGGAAGGGTTCCAA
1521 GCCTCTAAAAATGTGCTTTGTGATCAGGAGTGCGCTCCAAACCAAATACGCGCGCTGCCCTTTCGAGGCCAGTGAGCTCA
1601 GCCTCCAAGGCTTTAAAGCCACATTTCAGCAAGAGAAAGCGCTGAGAGCTCGCAGGTTCATTAAAGAAGGCAAAGCACTG
1681 GTTTCTCTCCTTAGAAAAGTAGGTTTCTTGGCTTGATGTAGACTGGCTTGCTTTGATTTTTAGTGAAGGGAATGTACGTA
1761 AAACAAAATAGGGCTTGGCTGGTCAAAGGAGACAAGCAGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGG
1841 ATGGATGAATAGATAGATGGTGTTTGCATGTAAATTGCAGAGAAAACAAAACCAAAGCTGATTGGAAACAATTAATTGTG
1921 GGTGTCTGAGGGGGAAGGTCGCAGCTTTGGGCAGCTTTGAGAAGCGGTACAAGAGTTCTGTGCCTGTGTGTCCAGCCCTG
2001 GAGCCAGCCAGTGCATTTATTTTAAGCTCTTAGAAGCAACTCCTTGGCCCAGGAATGCGTGACCCCTGAGATGGGTCCAC
2081 GCATCTCTCTACACTTCCTTCTCTCCGTGGGATACTGGACTCGTGCCTCTGCGCCCATTCTCTTCTCACGCATATCCATG
2161 AGCTTTAATTTCACTTTCTGATCACGGTACGTCCATAAAGCCAGTATTACACTTAAATGAAGTATTCTTTTTTGTAATCG
2241 TTTTTTTTAGAAGGTAAACAAATTTAATAAAGCTACCAATAATGTTGATGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacacacUCCUUGUUCUCUGUu 5'
                 | ||| |||||||| 
Target 5' gaaagaaAAGAAAAAGAGACAa 3'
971 - 992 159.00 -12.60
2
miRNA  3' gacacacuccUUG---UUCUCUGUu 5'
                    |||   |||||||| 
Target 5' tcccagcgcaAACTTAAAGAGACAg 3'
1285 - 1309 148.00 -10.40
3
miRNA  3' gacACACUCCUUGU---------UCUCUGUu 5'
             || |:| |||:         ||||||| 
Target 5' gccTGCGGGAAACGGGGCTTGCCAGAGACAc 3'
1387 - 1417 147.00 -14.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26731106 2 COSMIC
COSN30118402 3 COSMIC
COSN30458332 7 COSMIC
COSN28850479 13 COSMIC
COSN31582084 15 COSMIC
COSN20079554 22 COSMIC
COSN8604921 23 COSMIC
COSN30457260 30 COSMIC
COSN30147073 32 COSMIC
COSN31961497 53 COSMIC
COSN24400266 71 COSMIC
COSN19651663 73 COSMIC
COSN30540167 103 COSMIC
COSN28700456 114 COSMIC
COSN30542558 145 COSMIC
COSN28770656 160 COSMIC
COSN30541112 473 COSMIC
COSN30541119 474 COSMIC
COSN28767581 490 COSMIC
COSN20232193 724 COSMIC
COSN1760294 815 COSMIC
COSN26251179 1145 COSMIC
COSN20115442 1419 COSMIC
COSN23358367 1757 COSMIC
COSN20115440 1799 COSMIC
COSN20093513 1810 COSMIC
COSN8256171 1936 COSMIC
COSN6666901 1976 COSMIC
rs4804573 2 GWAS
rs11668313 978 GWAS
rs3185010 1392 GWAS
rs7188 2095 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs199966367 1 dbSNP
rs4804573 2 dbSNP
rs867770253 3 dbSNP
rs1325710330 6 dbSNP
rs1375079226 10 dbSNP
rs749508261 13 dbSNP
rs777918624 14 dbSNP
rs546422721 15 dbSNP
rs947929094 16 dbSNP
rs1448032577 17 dbSNP
rs756218023 18 dbSNP
rs1301904749 23 dbSNP
rs1332834734 25 dbSNP
rs1415678578 28 dbSNP
rs548896322 29 dbSNP
rs372922788 30 dbSNP
rs199813944 33 dbSNP
rs1003285137 34 dbSNP
rs1211273443 36 dbSNP
rs755569233 39 dbSNP
rs527527895 40 dbSNP
rs766743147 41 dbSNP
rs962250513 47 dbSNP
rs1191491764 50 dbSNP
rs763285208 50 dbSNP
rs184022857 54 dbSNP
rs1471373185 55 dbSNP
rs1189359757 70 dbSNP
rs541161277 71 dbSNP
rs1165249088 73 dbSNP
rs754885746 77 dbSNP
rs984425386 85 dbSNP
rs1324261268 87 dbSNP
rs1391549805 103 dbSNP
rs574713155 112 dbSNP
rs1295412896 113 dbSNP
rs1487857595 114 dbSNP
rs1036852423 127 dbSNP
rs112277786 128 dbSNP
rs1284477134 130 dbSNP
rs1355171258 135 dbSNP
rs753812923 143 dbSNP
rs1244529262 145 dbSNP
rs1211658397 147 dbSNP
rs1269770989 149 dbSNP
rs532337724 151 dbSNP
rs113465835 159 dbSNP
rs4804572 160 dbSNP
rs1189676155 162 dbSNP
rs760481891 163 dbSNP
rs900028644 176 dbSNP
rs191225384 177 dbSNP
rs1162989174 189 dbSNP
rs1226956632 191 dbSNP
rs932570587 203 dbSNP
rs1331422664 205 dbSNP
rs920911287 209 dbSNP
rs1334241859 212 dbSNP
rs1008498882 215 dbSNP
rs1308017097 218 dbSNP
rs369843622 223 dbSNP
rs555281316 224 dbSNP
rs542847005 230 dbSNP
rs988932856 231 dbSNP
rs956248288 237 dbSNP
rs903861233 244 dbSNP
rs1455474634 251 dbSNP
rs1346792779 252 dbSNP
rs1485350130 256 dbSNP
rs774375551 257 dbSNP
rs948121293 269 dbSNP
rs1414406061 270 dbSNP
rs748882141 274 dbSNP
rs764379184 280 dbSNP
rs1362637766 282 dbSNP
rs1003097699 283 dbSNP
rs992376000 286 dbSNP
rs970731060 287 dbSNP
rs572637578 290 dbSNP
rs1374326028 305 dbSNP
rs1412338896 306 dbSNP
rs1194958904 335 dbSNP
rs1455039241 339 dbSNP
rs1022944830 345 dbSNP
rs995535954 351 dbSNP
rs1390643275 359 dbSNP
rs1304589331 366 dbSNP
rs776827092 369 dbSNP
rs1233889705 376 dbSNP
rs1279477776 380 dbSNP
rs1347277224 383 dbSNP
rs898573539 386 dbSNP
rs199747781 396 dbSNP
rs940629550 398 dbSNP
rs553555326 411 dbSNP
rs1177049321 413 dbSNP
rs907747096 415 dbSNP
rs1004302642 418 dbSNP
rs1435206198 432 dbSNP
rs890929269 453 dbSNP
rs1051384557 461 dbSNP
rs984706091 462 dbSNP
rs139229161 463 dbSNP
rs951728310 469 dbSNP
rs377252603 471 dbSNP
rs571216311 474 dbSNP
rs1209675205 475 dbSNP
rs763148964 478 dbSNP
rs1296027118 484 dbSNP
rs1369505762 487 dbSNP
rs1387091174 488 dbSNP
rs892112 490 dbSNP
rs1282494512 501 dbSNP
rs974516013 506 dbSNP
rs1235148094 510 dbSNP
rs144505746 519 dbSNP
rs1204095197 521 dbSNP
rs946421317 524 dbSNP
rs1019793896 526 dbSNP
rs987813004 530 dbSNP
rs1363804752 531 dbSNP
rs1008779195 535 dbSNP
rs748279405 536 dbSNP
rs1289296177 538 dbSNP
rs1427370358 540 dbSNP
rs1465170976 542 dbSNP
rs1351239452 543 dbSNP
rs1458258091 543 dbSNP
rs1031253107 555 dbSNP
rs1357081831 560 dbSNP
rs1392274842 601 dbSNP
rs59781064 602 dbSNP
rs1001064054 603 dbSNP
rs903891039 604 dbSNP
rs3826812 613 dbSNP
rs527479548 615 dbSNP
rs948178813 619 dbSNP
rs896532201 627 dbSNP
rs1323694082 638 dbSNP
rs1214777536 640 dbSNP
rs746340224 645 dbSNP
rs1056305643 646 dbSNP
rs970321978 647 dbSNP
rs1430876259 656 dbSNP
rs1023672285 669 dbSNP
rs940478179 681 dbSNP
rs1262786294 683 dbSNP
rs1181655054 685 dbSNP
rs962663242 692 dbSNP
rs777304054 705 dbSNP
rs1318431264 706 dbSNP
rs771364645 713 dbSNP
rs1424017885 714 dbSNP
rs1004271850 716 dbSNP
rs1415401819 723 dbSNP
rs1458580340 724 dbSNP
rs1321164975 725 dbSNP
rs1344510521 736 dbSNP
rs930529875 746 dbSNP
rs1430150094 760 dbSNP
rs576855249 763 dbSNP
rs547456421 764 dbSNP
rs1272647347 776 dbSNP
rs974378645 781 dbSNP
rs965830760 782 dbSNP
rs1446925756 795 dbSNP
rs911592257 799 dbSNP
rs1213105830 803 dbSNP
rs899743502 805 dbSNP
rs1043665063 810 dbSNP
rs988576222 812 dbSNP
rs1254895405 814 dbSNP
rs1473478664 816 dbSNP
rs1158897228 825 dbSNP
rs1407248554 839 dbSNP
rs532471658 847 dbSNP
rs1052067026 848 dbSNP
rs747405849 852 dbSNP
rs957126544 857 dbSNP
rs1415071853 858 dbSNP
rs558687461 859 dbSNP
rs564894427 860 dbSNP
rs538782217 861 dbSNP
rs1412143334 867 dbSNP
rs968247245 872 dbSNP
rs1023603165 873 dbSNP
rs1222571033 884 dbSNP
rs748111297 885 dbSNP
rs927729812 901 dbSNP
rs1348000863 902 dbSNP
rs761487406 906 dbSNP
rs1374168359 915 dbSNP
rs543401256 920 dbSNP
rs896569012 925 dbSNP
rs1483827785 927 dbSNP
rs1182325857 929 dbSNP
rs1422406569 930 dbSNP
rs1369750182 931 dbSNP
rs1260117831 932 dbSNP
rs1192876220 938 dbSNP
rs1468347166 938 dbSNP
rs1056986695 947 dbSNP
rs1004958071 948 dbSNP
rs531775718 953 dbSNP
rs886298936 955 dbSNP
rs1048904570 956 dbSNP
rs1329712103 957 dbSNP
rs1335581360 960 dbSNP
rs1440406782 962 dbSNP
rs962968978 963 dbSNP
rs1372322984 964 dbSNP
rs1233013096 967 dbSNP
rs1197638330 971 dbSNP
rs1481545770 975 dbSNP
rs11668313 978 dbSNP
rs112024639 979 dbSNP
rs4804571 980 dbSNP
rs199523461 981 dbSNP
rs386806818 981 dbSNP
rs1435917380 983 dbSNP
rs1223460491 986 dbSNP
rs1294962181 986 dbSNP
rs572521811 986 dbSNP
rs75499942 987 dbSNP
rs537225678 989 dbSNP
rs1393353689 990 dbSNP
rs753949191 994 dbSNP
rs778453473 999 dbSNP
rs996690249 1003 dbSNP
rs911553543 1006 dbSNP
rs1392658451 1011 dbSNP
rs1328339782 1013 dbSNP
rs1395922518 1015 dbSNP
rs563382411 1019 dbSNP
rs1301790294 1021 dbSNP
rs1366775116 1022 dbSNP
rs1293437486 1032 dbSNP
rs1022093698 1058 dbSNP
rs1010752704 1064 dbSNP
rs1229883408 1066 dbSNP
rs1420472160 1068 dbSNP
rs1273594812 1071 dbSNP
rs754513860 1073 dbSNP
rs988995855 1074 dbSNP
rs746486819 1099 dbSNP
rs1193951805 1103 dbSNP
rs556341115 1108 dbSNP
rs1410058912 1110 dbSNP
rs1372790003 1111 dbSNP
rs1474541907 1112 dbSNP
rs537420934 1116 dbSNP
rs1438433790 1117 dbSNP
rs1461212463 1119 dbSNP
rs866321522 1120 dbSNP
rs1387742561 1129 dbSNP
rs1382367385 1131 dbSNP
rs568756661 1139 dbSNP
rs1003654378 1143 dbSNP
rs1266823676 1148 dbSNP
rs955771153 1149 dbSNP
rs1045173811 1157 dbSNP
rs1472115559 1161 dbSNP
rs112053149 1163 dbSNP
rs979539803 1164 dbSNP
rs186455621 1165 dbSNP
rs116256300 1170 dbSNP
rs1328003228 1174 dbSNP
rs941576229 1178 dbSNP
rs1012495218 1188 dbSNP
rs1445284007 1190 dbSNP
rs534114673 1193 dbSNP
rs1240808395 1201 dbSNP
rs1335821999 1203 dbSNP
rs779975715 1206 dbSNP
rs1035011571 1209 dbSNP
rs1475109778 1210 dbSNP
rs796803361 1222 dbSNP
rs1005397397 1223 dbSNP
rs534707421 1225 dbSNP
rs886495353 1232 dbSNP
rs1326934733 1241 dbSNP
rs566498783 1243 dbSNP
rs1158430082 1247 dbSNP
rs750226123 1252 dbSNP
rs955600166 1253 dbSNP
rs551168304 1258 dbSNP
rs543396003 1259 dbSNP
rs1039396002 1270 dbSNP
rs975871613 1273 dbSNP
rs116850924 1274 dbSNP
rs181480419 1277 dbSNP
rs114268284 1279 dbSNP
rs1348653834 1282 dbSNP
rs934422405 1286 dbSNP
rs925669843 1291 dbSNP
rs561358918 1292 dbSNP
rs1186011782 1293 dbSNP
rs1253114473 1297 dbSNP
rs892113 1300 dbSNP
rs765363913 1308 dbSNP
rs916744035 1312 dbSNP
rs1194230877 1313 dbSNP
rs991504821 1313 dbSNP
rs1464257859 1329 dbSNP
rs1281963764 1331 dbSNP
rs759701944 1334 dbSNP
rs528000214 1352 dbSNP
rs574507658 1353 dbSNP
rs777212205 1359 dbSNP
rs1254842139 1364 dbSNP
rs552151110 1367 dbSNP
rs771561160 1369 dbSNP
rs1373774117 1374 dbSNP
rs1236668244 1376 dbSNP
rs950781604 1380 dbSNP
rs370184830 1385 dbSNP
rs545615672 1388 dbSNP
rs3185010 1392 dbSNP
rs150866270 1393 dbSNP
rs1195562543 1399 dbSNP
rs1249116061 1400 dbSNP
rs898939440 1400 dbSNP
rs1017418380 1403 dbSNP
rs1009247176 1412 dbSNP
rs78649129 1420 dbSNP
rs1491555597 1421 dbSNP
rs573529252 1421 dbSNP
rs908793879 1422 dbSNP
rs16423 1423 dbSNP
rs3041983 1423 dbSNP
rs796703897 1423 dbSNP
rs1461328810 1429 dbSNP
rs555344581 1433 dbSNP
rs1395823350 1436 dbSNP
rs1053204449 1439 dbSNP
rs1325093705 1445 dbSNP
rs1370374480 1450 dbSNP
rs1217529604 1467 dbSNP
rs75254697 1468 dbSNP
rs1308299172 1469 dbSNP
rs143366219 1473 dbSNP
rs975460561 1474 dbSNP
rs1470049608 1475 dbSNP
rs1042819221 1480 dbSNP
rs948457234 1483 dbSNP
rs374533924 1486 dbSNP
rs1252865830 1491 dbSNP
rs990976125 1501 dbSNP
rs554872150 1503 dbSNP
rs539222096 1506 dbSNP
rs1447164875 1507 dbSNP
rs8102330 1508 dbSNP
rs928200890 1514 dbSNP
rs549837690 1530 dbSNP
rs983702148 1531 dbSNP
rs1349388978 1533 dbSNP
rs950729241 1548 dbSNP
rs538342206 1551 dbSNP
rs1228304357 1552 dbSNP
rs13345490 1553 dbSNP
rs549350187 1554 dbSNP
rs1392164889 1563 dbSNP
rs139341354 1569 dbSNP
rs747795459 1570 dbSNP
rs190687695 1571 dbSNP
rs186390378 1572 dbSNP
rs533530502 1573 dbSNP
rs563096879 1574 dbSNP
rs748797860 1575 dbSNP
rs898908466 1579 dbSNP
rs1218490717 1580 dbSNP
rs1168046813 1584 dbSNP
rs904222348 1585 dbSNP
rs1191093033 1589 dbSNP
rs1259155613 1590 dbSNP
rs1016062342 1591 dbSNP
rs1042683298 1593 dbSNP
rs887241421 1594 dbSNP
rs1415662987 1604 dbSNP
rs543925049 1608 dbSNP
rs1047241668 1610 dbSNP
rs1012634540 1624 dbSNP
rs779603047 1633 dbSNP
rs1345889008 1638 dbSNP
rs1453081398 1639 dbSNP
rs181364693 1640 dbSNP
rs116960640 1641 dbSNP
rs750369974 1651 dbSNP
rs111870962 1652 dbSNP
rs1203829437 1659 dbSNP
rs371622175 1663 dbSNP
rs929525473 1669 dbSNP
rs915244621 1675 dbSNP
rs920612862 1677 dbSNP
rs1226010395 1679 dbSNP
rs1195779300 1683 dbSNP
rs989488512 1686 dbSNP
rs1213791008 1687 dbSNP
rs973372161 1689 dbSNP
rs1282103008 1699 dbSNP
rs935431569 1708 dbSNP
rs1356078352 1711 dbSNP
rs923746444 1712 dbSNP
rs1291897984 1717 dbSNP
rs1471014393 1726 dbSNP
rs1177730107 1735 dbSNP
rs1235300365 1735 dbSNP
rs1407133706 1735 dbSNP
rs965164691 1736 dbSNP
rs950682599 1742 dbSNP
rs771145242 1743 dbSNP
rs1307450478 1751 dbSNP
rs987956353 1757 dbSNP
rs540218623 1758 dbSNP
rs1312459225 1774 dbSNP
rs1031451049 1777 dbSNP
rs762675137 1782 dbSNP
rs1023587541 1787 dbSNP
rs111729091 1795 dbSNP
rs1280689787 1797 dbSNP
rs968579947 1798 dbSNP
rs146890804 1799 dbSNP
rs749751819 1799 dbSNP
rs1021255205 1800 dbSNP
rs963001375 1801 dbSNP
rs990483783 1801 dbSNP
rs1209746534 1802 dbSNP
rs1276001550 1803 dbSNP
rs1204916502 1807 dbSNP
rs1440147354 1807 dbSNP
rs1015946425 1808 dbSNP
rs1356391094 1809 dbSNP
rs1330781162 1810 dbSNP
rs1394767759 1810 dbSNP
rs774360545 1811 dbSNP
rs557612447 1812 dbSNP
rs920520660 1815 dbSNP
rs998395831 1816 dbSNP
rs201162035 1820 dbSNP
rs1267709746 1822 dbSNP
rs1329951753 1823 dbSNP
rs199839456 1823 dbSNP
rs1358743817 1824 dbSNP
rs1393449923 1825 dbSNP
rs1313268418 1826 dbSNP
rs1334480536 1826 dbSNP
rs1232895940 1827 dbSNP
rs963241804 1827 dbSNP
rs200735691 1828 dbSNP
rs542336633 1830 dbSNP
rs1475950582 1831 dbSNP
rs1215001852 1832 dbSNP
rs781003790 1836 dbSNP
rs901417709 1836 dbSNP
rs1176309638 1837 dbSNP
rs1253524475 1838 dbSNP
rs376394863 1838 dbSNP
rs540893895 1838 dbSNP
rs756270058 1838 dbSNP
rs757029461 1839 dbSNP
rs4423524 1840 dbSNP
rs34975280 1841 dbSNP
rs577762409 1841 dbSNP
rs755020972 1841 dbSNP
rs775612874 1841 dbSNP
rs781517580 1841 dbSNP
rs372916922 1843 dbSNP
rs1039915654 1848 dbSNP
rs1167791193 1848 dbSNP
rs1328438093 1848 dbSNP
rs1423390855 1848 dbSNP
rs142958187 1848 dbSNP
rs143620081 1848 dbSNP
rs1464344773 1848 dbSNP
rs1476522624 1848 dbSNP
rs368900670 1848 dbSNP
rs369311228 1848 dbSNP
rs747276430 1848 dbSNP
rs773951632 1848 dbSNP
rs869248252 1848 dbSNP
rs942962103 1848 dbSNP
rs1234173254 1850 dbSNP
rs1205831790 1851 dbSNP
rs1468434386 1854 dbSNP
rs1448767089 1859 dbSNP
rs1271600129 1868 dbSNP
rs1215971818 1871 dbSNP
rs1335667005 1872 dbSNP
rs1194192710 1883 dbSNP
rs557131280 1889 dbSNP
rs1287925540 1890 dbSNP
rs893779503 1891 dbSNP
rs1190505947 1893 dbSNP
rs1419282077 1903 dbSNP
rs1053732210 1904 dbSNP
rs1222328733 1904 dbSNP
rs1386526177 1918 dbSNP
rs1375608391 1919 dbSNP
rs1297241719 1921 dbSNP
rs1280284478 1925 dbSNP
rs1056916313 1934 dbSNP
rs1003022336 1937 dbSNP
rs1442755780 1940 dbSNP
rs935400549 1941 dbSNP
rs549977594 1944 dbSNP
rs529824199 1945 dbSNP
rs1242559907 1948 dbSNP
rs535332453 1948 dbSNP
rs1262365780 1950 dbSNP
rs982347314 1959 dbSNP
rs1389412517 1965 dbSNP
rs1285655806 1969 dbSNP
rs7187 1976 dbSNP
rs1258658480 1977 dbSNP
rs916404556 1977 dbSNP
rs1423559071 1978 dbSNP
rs1186113194 1988 dbSNP
rs146435354 1990 dbSNP
rs963305646 1993 dbSNP
rs1157518878 1996 dbSNP
rs920811393 2004 dbSNP
rs1177285285 2005 dbSNP
rs1037706364 2019 dbSNP
rs1313070517 2039 dbSNP
rs1401257851 2043 dbSNP
rs76643934 2044 dbSNP
rs950510152 2045 dbSNP
rs534582884 2058 dbSNP
rs10425522 2059 dbSNP
rs1351513332 2061 dbSNP
rs1236808003 2062 dbSNP
rs965538740 2071 dbSNP
rs1483151529 2074 dbSNP
rs954936836 2080 dbSNP
rs1469174106 2081 dbSNP
rs1018410141 2082 dbSNP
rs1178496734 2083 dbSNP
rs1377986884 2090 dbSNP
rs1260568842 2092 dbSNP
rs924463464 2093 dbSNP
rs1213905842 2094 dbSNP
rs7188 2095 dbSNP
rs1376681226 2099 dbSNP
rs572366724 2100 dbSNP
rs1284979256 2106 dbSNP
rs1299652751 2106 dbSNP
rs766617092 2107 dbSNP
rs1445958458 2109 dbSNP
rs894084819 2112 dbSNP
rs1053701187 2114 dbSNP
rs1021537894 2117 dbSNP
rs1302326462 2122 dbSNP
rs1013243456 2123 dbSNP
rs1301131359 2132 dbSNP
rs552899386 2133 dbSNP
rs1198599466 2142 dbSNP
rs902593645 2145 dbSNP
rs1371451907 2149 dbSNP
rs958427444 2150 dbSNP
rs189387426 2152 dbSNP
rs949510154 2156 dbSNP
rs916389185 2157 dbSNP
rs1171998771 2159 dbSNP
rs1373463995 2175 dbSNP
rs1002643586 2179 dbSNP
rs1464863889 2184 dbSNP
rs1168497186 2185 dbSNP
rs1054985621 2190 dbSNP
rs529507023 2191 dbSNP
rs561798079 2195 dbSNP
rs1366920628 2196 dbSNP
rs1385344559 2217 dbSNP
rs1346619306 2230 dbSNP
rs1159139735 2232 dbSNP
rs1433533206 2234 dbSNP
rs117466427 2240 dbSNP
rs528040501 2241 dbSNP
rs1218368315 2244 dbSNP
rs112631624 2248 dbSNP
rs922935918 2249 dbSNP
rs1264352410 2251 dbSNP
rs373826793 2253 dbSNP
rs1037988842 2277 dbSNP
rs943603885 2278 dbSNP
rs889144788 2279 dbSNP
rs1263427061 2282 dbSNP
rs1052171560 2287 dbSNP
rs1477412205 2288 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000586659.1 | 3UTR | CAAGCAGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000586659.1 | 3UTR | AAGCAGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000586659.1 | 3UTR | AGCAGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAUGGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
150 hsa-miR-6818-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112122 TIMM17A translocase of inner mitochondrial membrane 17A 2 6
MIRT262243 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT446689 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT449923 TPST2 tyrosylprotein sulfotransferase 2 2 2
MIRT464356 USP12P1 ubiquitin specific peptidase 12 pseudogene 1 2 2
MIRT485703 CBX7 chromobox 7 2 2
MIRT497478 XPR1 xenotropic and polytropic retrovirus receptor 1 2 4
MIRT499435 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT514246 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT515032 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515065 PLA2G2C phospholipase A2 group IIC 2 2
MIRT520235 USP9X ubiquitin specific peptidase 9, X-linked 2 4
MIRT523685 FHL2 four and a half LIM domains 2 2 4
MIRT525524 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT525838 FAR2 fatty acyl-CoA reductase 2 2 2
MIRT528583 PTGER3 prostaglandin E receptor 3 2 2
MIRT530404 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530703 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT535118 PLSCR4 phospholipid scramblase 4 2 2
MIRT539880 IRGQ immunity related GTPase Q 2 2
MIRT540195 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540938 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541501 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT542544 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542559 ZNF280B zinc finger protein 280B 2 2
MIRT542689 RPS15A ribosomal protein S15a 2 2
MIRT548759 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT549735 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT553060 ULK1 unc-51 like autophagy activating kinase 1 2 2
MIRT556303 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT560816 DIP2A disco interacting protein 2 homolog A 2 2
MIRT567455 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT575143 Cd93 CD93 antigen 2 2
MIRT607217 ACSM2A acyl-CoA synthetase medium chain family member 2A 2 4
MIRT607286 CD300E CD300e molecule 2 6
MIRT607302 RREB1 ras responsive element binding protein 1 2 6
MIRT608645 ABCF3 ATP binding cassette subfamily F member 3 2 4
MIRT611095 MYO1F myosin IF 2 4
MIRT611576 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT614271 WSCD2 WSC domain containing 2 2 2
MIRT614855 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT617114 KANK2 KN motif and ankyrin repeat domains 2 2 2
MIRT618002 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618028 CTU1 cytosolic thiouridylase subunit 1 2 2
MIRT619062 BSND barttin CLCNK type accessory beta subunit 2 4
MIRT619289 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619356 CFHR5 complement factor H related 5 2 2
MIRT620725 CCL16 C-C motif chemokine ligand 16 2 2
MIRT620913 LRRTM2 leucine rich repeat transmembrane neuronal 2 2 2
MIRT621902 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT622025 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT622556 PTPN3 protein tyrosine phosphatase, non-receptor type 3 2 2
MIRT623137 NCKAP1 NCK associated protein 1 2 2
MIRT623140 NAV2 neuron navigator 2 2 2
MIRT623701 HHAT hedgehog acyltransferase 2 2
MIRT624602 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT625944 OLIG3 oligodendrocyte transcription factor 3 2 2
MIRT625988 SPATA17 spermatogenesis associated 17 2 2
MIRT628028 LSAMP limbic system-associated membrane protein 2 2
MIRT635521 MC2R melanocortin 2 receptor 2 2
MIRT638916 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT639796 EPX eosinophil peroxidase 2 2
MIRT640344 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT644806 VLDLR very low density lipoprotein receptor 2 2
MIRT645303 AGTRAP angiotensin II receptor associated protein 2 2
MIRT645629 SYTL4 synaptotagmin like 4 2 2
MIRT645683 TBC1D13 TBC1 domain family member 13 2 2
MIRT646216 DUSP10 dual specificity phosphatase 10 2 2
MIRT648505 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT649748 UTP20 UTP20, small subunit processome component 2 2
MIRT649797 CLEC2D C-type lectin domain family 2 member D 2 2
MIRT650482 UFM1 ubiquitin fold modifier 1 2 2
MIRT653199 SP9 Sp9 transcription factor 2 2
MIRT655741 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT659978 C2CD2L C2CD2 like 2 2
MIRT660350 BAG4 BCL2 associated athanogene 4 2 2
MIRT662185 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663290 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT666817 PRCP prolylcarboxypeptidase 2 2
MIRT671665 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT671838 PDE3A phosphodiesterase 3A 2 2
MIRT672193 F2 coagulation factor II, thrombin 2 2
MIRT673870 KLF2 Kruppel like factor 2 2 2
MIRT683563 CARD8 caspase recruitment domain family member 8 2 2
MIRT684545 ZNF708 zinc finger protein 708 2 2
MIRT685140 TACR3 tachykinin receptor 3 2 2
MIRT685413 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT686039 SLC5A5 solute carrier family 5 member 5 2 2
MIRT686126 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT687473 NHLRC2 NHL repeat containing 2 2 2
MIRT687946 HHIP hedgehog interacting protein 2 2
MIRT688171 FRRS1 ferric chelate reductase 1 2 2
MIRT688295 FAM208A family with sequence similarity 208 member A 2 2
MIRT689044 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT689194 ZNF574 zinc finger protein 574 2 2
MIRT691253 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT695358 PHAX phosphorylated adaptor for RNA export 2 2
MIRT696674 APOC3 apolipoprotein C3 2 2
MIRT697358 ZNF394 zinc finger protein 394 2 2
MIRT697604 XIAP X-linked inhibitor of apoptosis 2 2
MIRT697726 USP6NL USP6 N-terminal like 2 2
MIRT697776 UBXN7 UBX domain protein 7 2 2
MIRT698478 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT698984 SPAG9 sperm associated antigen 9 2 2
MIRT699851 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT700172 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT704339 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT704589 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT705836 AHCY adenosylhomocysteinase 2 2
MIRT707085 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT707132 TRA2B transformer 2 beta homolog 2 2
MIRT707145 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT707234 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT707347 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT707445 PPFIBP1 PPFIA binding protein 1 2 2
MIRT707494 AXL AXL receptor tyrosine kinase 2 2
MIRT707638 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT707690 FAM118A family with sequence similarity 118 member A 2 2
MIRT707706 CDC6 cell division cycle 6 2 2
MIRT707817 TMEM170A transmembrane protein 170A 2 2
MIRT707957 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT707996 NUDT4 nudix hydrolase 4 2 2
MIRT708026 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT708058 LIX1L limb and CNS expressed 1 like 2 2
MIRT708089 KIAA1671 KIAA1671 2 2
MIRT708125 GK5 glycerol kinase 5 (putative) 2 2
MIRT708194 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT708201 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT710503 BSDC1 BSD domain containing 1 2 2
MIRT711308 IFNGR2 interferon gamma receptor 2 2 2
MIRT711740 DTX1 deltex E3 ubiquitin ligase 1 2 2
MIRT713202 SOCS6 suppressor of cytokine signaling 6 2 2
MIRT714380 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT715210 NPVF neuropeptide VF precursor 2 2
MIRT715559 EPHB4 EPH receptor B4 2 2
MIRT715835 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT716680 HLA-B major histocompatibility complex, class I, B 2 2
MIRT717660 THBS2 thrombospondin 2 2 2
MIRT718132 PALM paralemmin 2 2
MIRT718322 METTL7A methyltransferase like 7A 2 2
MIRT720693 RNF217 ring finger protein 217 2 2
MIRT720727 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT721376 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721983 FAM214B family with sequence similarity 214 member B 2 2
MIRT722163 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT722881 MOB3A MOB kinase activator 3A 2 2
MIRT723218 FMNL3 formin like 3 2 2
MIRT723788 MUC17 mucin 17, cell surface associated 2 2
MIRT724093 TMEM199 transmembrane protein 199 2 2
MIRT725265 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6818-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)

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