pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol JRKL   
Synonyms HHMJG
Description JRK like
Transcript NM_003772   
Expression
Putative miRNA Targets on JRKL
3'UTR of JRKL
(miRNA target sites are highlighted)
>JRKL|NM_003772|3'UTR
   1 TGTCATTTCAATTTTATTGTTCTGCTCATTGTGTTTGTGACAAACTCTTTGCAATATGGCTTAATTTTCTTTGTGTTCTG
  81 AATTCTCAGACTTGGTCCTGTGAAATACAGGCACAAAATGTATCTGAAGTGGTTTGAGGATTATGTGTTTTCATCATCTG
 161 TGTCTTTTGTCCTTTTATTTGTACAGATAATCAGAAGATGATACTGAATAGATATAAATTACATGTACACATGTATTCAC
 241 TTTTTAGAATCTGCAATTATACCTTCTGTAACAGTGGCATTCCCTTAATTTTCTAGTGAAAGTTAGAGATAACTGAACAG
 321 ACTGAAGCACTTTTCTGAAATCTTTTGCTTGATTTATGAAGGCTGCCATAGTTATCTTTTCTTGTGTTAACCATCTTAAA
 401 TGATGTTTTGTATATTTTAATAGACTGATAGGATGAGAAAGATTTATATTATTAGATTTCAGGATGATTTATAATAATTC
 481 AAAAATGAAATTCAATAATGGGGAAATAATTATGAATTATAGAAATTATGCCTTCATTCTCTTACATTTGTGTGGGTTGC
 561 AAGAGGGGGAGATTATTCTGGAAATGAAGTAAATATGGGAAGTTATTGCCAAATGAGAGAGAAACTATGGGAAAGCTGAT
 641 CTATAAAGAGGCATTCTGATCAATTCATTTGTAGGAAACTGGGAAATAAAAACCTGGGGAACTTTAGGTTATTTATACAA
 721 AGGGAATAAATAGGCTGATTTTAATTTGGTAAGTTGATCTTTTTATTATGAATTTGGTAATAGTATAGGTTTATTATTTA
 801 TTCATCTAATTTTATAGTACAGGTTTTGTAATGTTACATGTGATGATATGAGCTCCCACCTTATATGGGGGAACATCTTG
 881 GGAATTTGAGATTTAATAAGTTTTTTTTTTTTTTTTTTTAGTGTTTTTACTGCATACTCACAAATGTTGTCTATAATTTG
 961 AAAAATATTGTCATATCTGGCCCTTTGATGAGAAAAGGAAATTACAATAATAAAGTTTTATGATTTTAAATAAGTCATAT
1041 GTTTGTATCCTGTTTTATGAAGAAAGCAGAAATAATTACTGAAAGTGCCAGACACTAAGGAATATTATTGTTTATTATTT
1121 TAATACATATAAAAAGGGATTAATCTGCTAAAATGTAATCTAAATCAGAATTTTGATAAATTTTTTTTGTAAACTAAGTA
1201 TGTTTATTCAAGACATTGAAACTACTTTGCACATATGAATATTAATGTAACTTGTAATTTAAAAGTAAAGTGTTTCCATG
1281 CTATTTCATGTTTTGGCCAAAAATTTTTAAAAAATAAATTACAATTGTTCTCTATTAGTAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuAGUGUU-UACAGGAAUUAuc 5'
             |::||| |||  ||||||  
Target 5' tctTTGCAATATG-GCTTAATtt 3'
46 - 67 138.00 -6.00
2
miRNA  3' cuUAGUGUU-UAC-AGGAAUUAUc 5'
            |||| || ||| | || |||| 
Target 5' taATCAGAAGATGATACTGAATAg 3'
188 - 211 136.00 -10.70
3
miRNA  3' cuUAGUGUU----UACAGGAAUUAuc 5'
            :| |||:    ||  |||||||  
Target 5' ctGTAACAGTGGCATTCCCTTAATtt 3'
266 - 291 134.00 -7.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20108650 50 COSMIC
COSN30122604 53 COSMIC
COSN30706241 57 COSMIC
COSN31592027 61 COSMIC
COSN31500112 81 COSMIC
COSN31542253 86 COSMIC
COSN15668336 170 COSMIC
COSN31595891 171 COSMIC
COSN30112193 212 COSMIC
COSN30125191 226 COSMIC
COSN30526552 232 COSMIC
COSN30143247 247 COSMIC
COSN26566290 411 COSMIC
COSN1551217 439 COSMIC
COSN31547258 456 COSMIC
COSN25763823 521 COSMIC
COSN5925363 568 COSMIC
COSN31540996 571 COSMIC
COSN31521073 622 COSMIC
COSN26641029 856 COSMIC
COSN31482581 877 COSMIC
COSN31535719 884 COSMIC
COSN24304103 921 COSMIC
COSN17388893 966 COSMIC
COSN15624627 1003 COSMIC
COSN15624629 1003 COSMIC
COSN30172892 1008 COSMIC
COSN30142400 1015 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs987334488 4 dbSNP
rs1316836240 10 dbSNP
rs1291780354 11 dbSNP
rs370269979 12 dbSNP
rs760304530 13 dbSNP
rs1462820197 17 dbSNP
rs1244644338 18 dbSNP
rs201814692 19 dbSNP
rs1165298704 25 dbSNP
rs1262487919 27 dbSNP
rs763667376 28 dbSNP
rs374979568 42 dbSNP
rs1322017738 45 dbSNP
rs10545425 48 dbSNP
rs796971195 48 dbSNP
rs200347595 50 dbSNP
rs966736008 55 dbSNP
rs957161647 58 dbSNP
rs868591292 59 dbSNP
rs1403265040 62 dbSNP
rs149748923 76 dbSNP
rs1303825752 79 dbSNP
rs865882964 86 dbSNP
rs979417690 90 dbSNP
rs1359156073 92 dbSNP
rs540871074 97 dbSNP
rs559110881 103 dbSNP
rs991544219 106 dbSNP
rs1377389377 109 dbSNP
rs113557354 110 dbSNP
rs1162892755 112 dbSNP
rs925308868 118 dbSNP
rs1363414397 119 dbSNP
rs377121993 121 dbSNP
rs1487045008 123 dbSNP
rs1263734151 127 dbSNP
rs1329778233 136 dbSNP
rs1344258593 137 dbSNP
rs1253966933 141 dbSNP
rs1225177842 142 dbSNP
rs747942698 142 dbSNP
rs1284213830 143 dbSNP
rs1440074550 146 dbSNP
rs1399457686 154 dbSNP
rs1324714203 165 dbSNP
rs572639620 165 dbSNP
rs746813599 165 dbSNP
rs774664455 165 dbSNP
rs1402132714 166 dbSNP
rs1335121524 169 dbSNP
rs1471197781 180 dbSNP
rs1429513196 181 dbSNP
rs1198607017 185 dbSNP
rs1286077721 197 dbSNP
rs1049240218 203 dbSNP
rs1476648595 204 dbSNP
rs1360285483 207 dbSNP
rs887833472 216 dbSNP
rs551604687 220 dbSNP
rs1441756010 222 dbSNP
rs1254081291 225 dbSNP
rs1290221574 231 dbSNP
rs1039432957 232 dbSNP
rs915813487 249 dbSNP
rs1218209810 250 dbSNP
rs949919026 255 dbSNP
rs1337704005 259 dbSNP
rs1271941406 260 dbSNP
rs564343449 264 dbSNP
rs1340389555 271 dbSNP
rs1045940905 273 dbSNP
rs560071218 274 dbSNP
rs773356344 279 dbSNP
rs939729422 282 dbSNP
rs998054310 284 dbSNP
rs1331135350 302 dbSNP
rs549893032 306 dbSNP
rs568570155 307 dbSNP
rs1029494142 311 dbSNP
rs1273259186 319 dbSNP
rs1422086030 324 dbSNP
rs1038112635 327 dbSNP
rs898197098 343 dbSNP
rs1472202746 347 dbSNP
rs996914251 351 dbSNP
rs1366625421 352 dbSNP
rs903122196 363 dbSNP
rs1050012265 366 dbSNP
rs1179255557 388 dbSNP
rs762929483 393 dbSNP
rs999071920 394 dbSNP
rs1196545814 406 dbSNP
rs1244407199 411 dbSNP
rs1032869527 413 dbSNP
rs1444723841 415 dbSNP
rs535949636 421 dbSNP
rs957336485 423 dbSNP
rs1196420492 430 dbSNP
rs1355788551 441 dbSNP
rs1383371263 442 dbSNP
rs1431397297 444 dbSNP
rs1313036828 449 dbSNP
rs891336552 468 dbSNP
rs1168322039 471 dbSNP
rs1248752627 475 dbSNP
rs1384187470 481 dbSNP
rs1308973123 484 dbSNP
rs1440549551 486 dbSNP
rs1337132153 504 dbSNP
rs1008407004 506 dbSNP
rs1021515728 507 dbSNP
rs1404423322 507 dbSNP
rs966829611 508 dbSNP
rs548050725 517 dbSNP
rs1425164979 522 dbSNP
rs1336435839 532 dbSNP
rs1471060670 535 dbSNP
rs4753750 535 dbSNP
rs959407352 546 dbSNP
rs779615104 560 dbSNP
rs915839220 564 dbSNP
rs1289597878 567 dbSNP
rs776762041 573 dbSNP
rs985343724 580 dbSNP
rs540142504 596 dbSNP
rs866104140 598 dbSNP
rs1285979815 599 dbSNP
rs1222402837 603 dbSNP
rs1353229868 611 dbSNP
rs1280540846 626 dbSNP
rs971692139 642 dbSNP
rs981317451 644 dbSNP
rs908399372 651 dbSNP
rs939826200 652 dbSNP
rs1228569202 654 dbSNP
rs943438912 657 dbSNP
rs1156894236 662 dbSNP
rs1402396472 668 dbSNP
rs1408390214 672 dbSNP
rs1171785318 675 dbSNP
rs1480198695 676 dbSNP
rs1251151190 680 dbSNP
rs558403487 684 dbSNP
rs1490548692 695 dbSNP
rs1262598359 696 dbSNP
rs933294801 705 dbSNP
rs751982571 713 dbSNP
rs1193654576 722 dbSNP
rs1458462501 724 dbSNP
rs1285326620 725 dbSNP
rs575966360 731 dbSNP
rs1038163503 735 dbSNP
rs903091330 737 dbSNP
rs998812777 749 dbSNP
rs1223565615 757 dbSNP
rs1339213461 758 dbSNP
rs1461370158 760 dbSNP
rs919636139 762 dbSNP
rs1053028 766 dbSNP
rs11549459 778 dbSNP
rs1432725731 782 dbSNP
rs1049829982 784 dbSNP
rs1345728490 786 dbSNP
rs1333246474 787 dbSNP
rs1468075757 791 dbSNP
rs893010291 794 dbSNP
rs549492797 800 dbSNP
rs1480905877 808 dbSNP
rs1430289033 809 dbSNP
rs1184873953 812 dbSNP
rs1487131557 815 dbSNP
rs1193836273 821 dbSNP
rs1372248000 837 dbSNP
rs555063849 844 dbSNP
rs1022688783 845 dbSNP
rs1265410322 847 dbSNP
rs1042603793 850 dbSNP
rs1316925472 855 dbSNP
rs971147297 857 dbSNP
rs902724950 860 dbSNP
rs756971850 866 dbSNP
rs1362568060 868 dbSNP
rs1000987155 870 dbSNP
rs1283576137 873 dbSNP
rs778368792 876 dbSNP
rs1337155801 898 dbSNP
rs200299383 898 dbSNP
rs767655092 900 dbSNP
rs768506912 900 dbSNP
rs1183462707 901 dbSNP
rs1491492782 901 dbSNP
rs201157332 901 dbSNP
rs760903212 901 dbSNP
rs761834872 901 dbSNP
rs959417135 902 dbSNP
rs1307463757 904 dbSNP
rs1391437419 909 dbSNP
rs1383230677 915 dbSNP
rs1480098477 918 dbSNP
rs1249327108 920 dbSNP
rs1378780613 920 dbSNP
rs1295510705 921 dbSNP
rs1237926237 922 dbSNP
rs1307516202 922 dbSNP
rs11021571 923 dbSNP
rs1324993767 924 dbSNP
rs11021572 925 dbSNP
rs1235966444 927 dbSNP
rs1243597342 928 dbSNP
rs1284803003 929 dbSNP
rs1323868063 930 dbSNP
rs1222352276 933 dbSNP
rs1260651862 947 dbSNP
rs1315459370 957 dbSNP
rs1445863703 961 dbSNP
rs4753751 974 dbSNP
rs985094037 980 dbSNP
rs909367154 982 dbSNP
rs181706691 984 dbSNP
rs1205576580 992 dbSNP
rs1025372509 1004 dbSNP
rs559125732 1011 dbSNP
rs1387695622 1013 dbSNP
rs1445052456 1023 dbSNP
rs1248888032 1046 dbSNP
rs866633290 1047 dbSNP
rs1178535254 1053 dbSNP
rs1480756609 1059 dbSNP
rs35254662 1060 dbSNP
rs1201396486 1070 dbSNP
rs1267480964 1072 dbSNP
rs577389382 1078 dbSNP
rs1361493174 1079 dbSNP
rs964867617 1083 dbSNP
rs1238041243 1090 dbSNP
rs1314865605 1093 dbSNP
rs1430205787 1108 dbSNP
rs1393295590 1118 dbSNP
rs1480258373 1124 dbSNP
rs970735543 1129 dbSNP
rs1174571339 1131 dbSNP
rs981795759 1137 dbSNP
rs974889491 1139 dbSNP
rs923335752 1144 dbSNP
rs11021573 1153 dbSNP
rs1161749377 1154 dbSNP
rs1196606535 1181 dbSNP
rs1419287846 1181 dbSNP
rs961202323 1181 dbSNP
rs923978241 1195 dbSNP
rs1269008444 1199 dbSNP
rs563633066 1199 dbSNP
rs775720364 1201 dbSNP
rs146352696 1216 dbSNP
rs1388858051 1220 dbSNP
rs1239578101 1223 dbSNP
rs764251335 1225 dbSNP
rs985207471 1229 dbSNP
rs1054343811 1237 dbSNP
rs912241604 1244 dbSNP
rs3098655 1251 dbSNP
rs893053492 1253 dbSNP
rs3133505 1254 dbSNP
rs1280979513 1256 dbSNP
rs1347427720 1261 dbSNP
rs3098654 1276 dbSNP
rs3133506 1295 dbSNP
rs1044265991 1303 dbSNP
rs906932509 1305 dbSNP
rs1318137160 1306 dbSNP
rs943711657 1310 dbSNP
rs1454667136 1312 dbSNP
rs1260066397 1319 dbSNP
rs1042659400 1325 dbSNP
rs1025977009 1331 dbSNP
rs1441904530 1332 dbSNP
rs1191866605 1333 dbSNP
rs902736421 1334 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_003772 | 3UTR | AUUUAAUAAGUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000458427.1 | 3UTR | UUGGGAAUUUGAGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000458427.1 | 3UTR | CUUGGGAAUUUGAGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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