pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DOCK4   
Synonyms -
Description dedicator of cytokinesis 4
Transcript NM_014705   
Expression
Putative miRNA Targets on DOCK4
3'UTR of DOCK4
(miRNA target sites are highlighted)
>DOCK4|NM_014705|3'UTR
   1 GTCACTTTTCTATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGATGAGAAGACATTTAGTGTAGG
  81 CACTTTAATAACTTACTCAGCTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCACAATATTAAAA
 161 GTTGCTGATCTAAAACGCCAGATGTTAAATGAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAAT
 241 AGTGATAAAGACTCCTTTTGTACCTTTTTATGTTCACTTTTTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTC
 321 AAACGATACAATGTGTGACAATGTTGTATCGTTTTTACTGAATACTTGATACTTGGAGAAAGCTTATTAAGTCAGTGCAC
 401 ATCCTAACACAGTGGTCCTTATTTTAGAAGACTTCTGTAAATAAGGCAAGGTTTATCAGTGCAGATCATCAGAATTAAAG
 481 TTCAAGCAGGCGAGCAAGACAGTATACTTAAGGGGTTGCAAAGCTTGGGACTGGAAATTGTTTTGTTCTTGAAACAAAAT
 561 ACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTACATTCGTAAAATTCTATTTTGTGAATTGGTAGCTAAATCCC
 641 TTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAATTTGCTTCAGAGTTCCAATCAGCTAGATTAA
 721 GCAAGAGGCTCCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCCTATATAAAATTTGTCATTGA
 801 ACAAGAGCAAATGCTGAAGTATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCAATACAGACAG
 881 TATTAAATTAATAGCTTAAGTGAAGAAAAAAAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTAT
 961 AAAAGGCAAGGGCATTAACTTTCAGTCCTGCACAAAATAAAAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTG
1041 TCTTAGCTGACCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGTAGACTTCTCTAGCTTGAATATTGCAACATAGCATCTT
1121 AGGTCTAGATAGGGATGCTAATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTTGTATGTAGTAATGTATTTTATATCTTT
1201 GTTTTTTCTTTTACTGACTGTTTATAACACTCAATTGACAATAGATATGAACTGTATTTTAAATCATACTGTTAAATATT
1281 TTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATGTTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGTGACCACT
1361 TTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGCTGGTTATAGAGGTTTTCTATAATAAATGTT
1441 CAAGTATTTTTGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAAAGTAAAAATAAACGCAAACA
1521 GTTGTTGATGCAGTATGATTGTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACATATGTGCTTTT
1601 AACAATTCTGCCATATTGACTTTACAATTTTGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGT
1681 GTTCATAATTGAGAAAAGGAACATATGCATTTTAGCTTTGTATCTTGCAAGTTTTGCAGTCAGAAATTTTTTGAACTAGC
1761 TTTTGCTTTTGATAACACTTCGTGTTTGTAACCACATTCATATATATATACATATATATGTGAAGCTCCATATTTCTGTT
1841 GCTTTAAAGAAGTAAAACCTTCCATTTAAATAAGATGACATGCATAAGATAACAAAGCTTCCTTGATTTCCTTTTCCTGT
1921 GTAATTTAATAGATTTGTTGACTAGTGCTTGGGCACATTATAAATCAGTGTTATTTGCTCTTGGAGCCATTTTTTAAAAA
2001 AAATTTTGGCAGTGAGCAGTTGAATTTATCTTGAATTTATCATGTGTGTGTATTTCTGAAGCAGCTACATAGCAGAACAT
2081 TTTAAGAGATTCTGTTAGCCCACATGTTCATGTTGGTTGCTGCTGAATGGTAAATATTAAATAAAATTACCAGATTAATC
2161 TTAATAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugccGAUCACCUGGUCCACUUCa 5'
              :|| | | ::| |||||| 
Target 5' taaaTTAATAGCTTAAGTGAAGa 3'
884 - 906 127.00 -8.20
2
miRNA  3' ugccgaucaccuggucCACUUCa 5'
                          |||||| 
Target 5' atatatacatatatatGTGAAGc 3'
1804 - 1826 120.00 -7.70
3
miRNA  3' ugCCGAUCACCUGGUCCACUUca 5'
            ||| ||| || ||| ||||  
Target 5' ttGGC-AGT-GAGCAGTTGAAtt 3'
2006 - 2026 119.00 -14.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30193207 14 COSMIC
COSN26973936 21 COSMIC
COSN30457080 22 COSMIC
COSN30130849 30 COSMIC
COSN30504641 37 COSMIC
COSN30525444 38 COSMIC
COSN4864374 66 COSMIC
COSN31569220 74 COSMIC
COSN26481456 228 COSMIC
COSN32056107 298 COSMIC
COSN28825565 312 COSMIC
COSN16806198 358 COSMIC
COSN22505767 365 COSMIC
COSN9820732 492 COSMIC
COSN31609750 857 COSMIC
COSN31580136 905 COSMIC
COSN30083323 933 COSMIC
COSN24302095 991 COSMIC
COSN31566300 1003 COSMIC
COSN31539731 1057 COSMIC
COSN31515209 1208 COSMIC
COSN23756565 1406 COSMIC
COSN31479833 1477 COSMIC
COSN8515236 1478 COSMIC
COSN9820731 1478 COSMIC
COSN9919557 1566 COSMIC
COSN31538725 1577 COSMIC
COSN8515235 1591 COSMIC
COSN26555119 1596 COSMIC
COSN24302094 1611 COSMIC
COSN20447813 1640 COSMIC
COSN31533514 1689 COSMIC
COSN30174605 1715 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1320655237 1 dbSNP
rs1482098788 3 dbSNP
rs942609820 9 dbSNP
rs1306520094 10 dbSNP
rs1429480023 11 dbSNP
rs1401872987 12 dbSNP
rs765356356 13 dbSNP
rs1455322328 19 dbSNP
rs1171013972 21 dbSNP
rs1456897712 22 dbSNP
rs1367309424 27 dbSNP
rs915269929 30 dbSNP
rs1054184690 31 dbSNP
rs750597108 34 dbSNP
rs755062170 35 dbSNP
rs753885054 38 dbSNP
rs1427235622 42 dbSNP
rs766255689 43 dbSNP
rs760611360 47 dbSNP
rs1386647745 55 dbSNP
rs575898941 56 dbSNP
rs982136583 60 dbSNP
rs565349132 66 dbSNP
rs1297117042 68 dbSNP
rs1018094534 74 dbSNP
rs916731877 76 dbSNP
rs1381935132 79 dbSNP
rs529660562 83 dbSNP
rs1251891261 88 dbSNP
rs1340005606 92 dbSNP
rs1159539617 94 dbSNP
rs557597291 100 dbSNP
rs1469623277 103 dbSNP
rs1042924366 107 dbSNP
rs1247018595 108 dbSNP
rs77723713 122 dbSNP
rs866107854 128 dbSNP
rs1373105182 129 dbSNP
rs1457871399 132 dbSNP
rs543720869 139 dbSNP
rs539290512 141 dbSNP
rs1397210100 143 dbSNP
rs1057321900 144 dbSNP
rs984197104 156 dbSNP
rs1214917266 157 dbSNP
rs1363286507 161 dbSNP
rs1356358061 173 dbSNP
rs951057591 177 dbSNP
rs576213528 181 dbSNP
rs141005790 187 dbSNP
rs928149025 190 dbSNP
rs367738602 191 dbSNP
rs1214089177 194 dbSNP
rs564366654 196 dbSNP
rs1484702280 198 dbSNP
rs910145052 199 dbSNP
rs1379811499 213 dbSNP
rs1297575603 215 dbSNP
rs901030632 217 dbSNP
rs1018116969 222 dbSNP
rs1186501719 228 dbSNP
rs1420653207 231 dbSNP
rs1006842288 235 dbSNP
rs1386843263 236 dbSNP
rs1455564736 236 dbSNP
rs1289634649 237 dbSNP
rs1362275806 238 dbSNP
rs545976333 241 dbSNP
rs1298548899 247 dbSNP
rs572540694 247 dbSNP
rs1053669166 248 dbSNP
rs1401644660 250 dbSNP
rs1394351142 252 dbSNP
rs935346330 255 dbSNP
rs902491765 263 dbSNP
rs1167022432 265 dbSNP
rs1287525455 277 dbSNP
rs977271115 278 dbSNP
rs553980763 279 dbSNP
rs1018751465 284 dbSNP
rs1046492278 285 dbSNP
rs1475831222 286 dbSNP
rs369879181 286 dbSNP
rs551850967 286 dbSNP
rs760992740 288 dbSNP
rs535798233 289 dbSNP
rs1264383117 295 dbSNP
rs1421225137 296 dbSNP
rs1160182620 297 dbSNP
rs991405552 299 dbSNP
rs942174159 306 dbSNP
rs574910386 311 dbSNP
rs983693674 312 dbSNP
rs1314866135 314 dbSNP
rs1376104258 316 dbSNP
rs76302618 317 dbSNP
rs905628186 322 dbSNP
rs771932707 325 dbSNP
rs1370983569 326 dbSNP
rs1225257758 331 dbSNP
rs1307363116 332 dbSNP
rs976537109 336 dbSNP
rs1231557579 340 dbSNP
rs1281876819 342 dbSNP
rs1485693209 354 dbSNP
rs1321857564 359 dbSNP
rs538178492 365 dbSNP
rs965115890 366 dbSNP
rs1216765165 368 dbSNP
rs1481862604 374 dbSNP
rs1178143737 383 dbSNP
rs910049773 389 dbSNP
rs1048711873 390 dbSNP
rs1175728270 392 dbSNP
rs1395823415 405 dbSNP
rs746657941 407 dbSNP
rs930199299 410 dbSNP
rs1352696168 413 dbSNP
rs918606361 421 dbSNP
rs1298552283 440 dbSNP
rs1017989812 441 dbSNP
rs1007137269 446 dbSNP
rs75210139 451 dbSNP
rs911316840 460 dbSNP
rs1348047507 463 dbSNP
rs371696810 464 dbSNP
rs1032685615 467 dbSNP
rs1309795755 470 dbSNP
rs766100593 479 dbSNP
rs1205789773 482 dbSNP
rs188132339 487 dbSNP
rs902543766 489 dbSNP
rs533642740 491 dbSNP
rs1168571648 492 dbSNP
rs1449022611 496 dbSNP
rs949355820 501 dbSNP
rs566521241 503 dbSNP
rs1411617895 510 dbSNP
rs1421684002 510 dbSNP
rs1171017755 513 dbSNP
rs867106840 514 dbSNP
rs1393516417 515 dbSNP
rs1424891920 518 dbSNP
rs1198600738 519 dbSNP
rs1431867559 523 dbSNP
rs1327579157 525 dbSNP
rs1010136297 529 dbSNP
rs774395085 534 dbSNP
rs182711749 539 dbSNP
rs1215721592 546 dbSNP
rs1035990477 548 dbSNP
rs1333237414 552 dbSNP
rs1215949629 556 dbSNP
rs1055193820 559 dbSNP
rs1464636099 561 dbSNP
rs1191245880 569 dbSNP
rs1256904928 569 dbSNP
rs1475768484 570 dbSNP
rs1196158524 576 dbSNP
rs1417072384 578 dbSNP
rs1319933259 589 dbSNP
rs1270632325 593 dbSNP
rs1474146403 593 dbSNP
rs1166844712 600 dbSNP
rs1232440800 601 dbSNP
rs1329196341 603 dbSNP
rs1315762250 605 dbSNP
rs1346514191 607 dbSNP
rs1430821976 609 dbSNP
rs942207308 611 dbSNP
rs905489475 616 dbSNP
rs1235633278 623 dbSNP
rs1044208870 628 dbSNP
rs1005967623 635 dbSNP
rs1286589600 640 dbSNP
rs909369581 647 dbSNP
rs1048472942 650 dbSNP
rs533764383 657 dbSNP
rs748861578 658 dbSNP
rs918290444 673 dbSNP
rs1484662804 676 dbSNP
rs1329407934 680 dbSNP
rs1189939335 684 dbSNP
rs1418369015 687 dbSNP
rs1469425293 698 dbSNP
rs976422842 699 dbSNP
rs1048575105 706 dbSNP
rs3801790 707 dbSNP
rs897418064 708 dbSNP
rs1401116250 720 dbSNP
rs1172564910 722 dbSNP
rs1464964160 727 dbSNP
rs1417210578 728 dbSNP
rs1041658757 742 dbSNP
rs1335607314 747 dbSNP
rs1379774395 750 dbSNP
rs1199978514 751 dbSNP
rs562178573 758 dbSNP
rs550039113 759 dbSNP
rs985197533 771 dbSNP
rs958137497 775 dbSNP
rs1278323407 782 dbSNP
rs1486681823 784 dbSNP
rs1176247958 785 dbSNP
rs944053976 793 dbSNP
rs1032156360 800 dbSNP
rs999435085 803 dbSNP
rs966608713 807 dbSNP
rs531926581 812 dbSNP
rs985542026 815 dbSNP
rs1470324083 818 dbSNP
rs1172589132 821 dbSNP
rs1024810959 824 dbSNP
rs1013559909 825 dbSNP
rs914427530 827 dbSNP
rs895120753 853 dbSNP
rs1174895781 854 dbSNP
rs3801791 857 dbSNP
rs1199838015 868 dbSNP
rs1331319521 871 dbSNP
rs1006288495 874 dbSNP
rs1336686093 875 dbSNP
rs887982362 878 dbSNP
rs762882117 893 dbSNP
rs988619483 894 dbSNP
rs1301508806 896 dbSNP
rs1047882796 897 dbSNP
rs1257561303 900 dbSNP
rs1234675447 901 dbSNP
rs1376443014 902 dbSNP
rs1307429464 905 dbSNP
rs189665841 912 dbSNP
rs113170416 916 dbSNP
rs981764815 916 dbSNP
rs969785544 919 dbSNP
rs1336480314 920 dbSNP
rs1274899637 928 dbSNP
rs1192688918 938 dbSNP
rs1250753316 958 dbSNP
rs1455254716 960 dbSNP
rs745713311 960 dbSNP
rs778604118 966 dbSNP
rs1193730219 967 dbSNP
rs923518872 980 dbSNP
rs1371949677 982 dbSNP
rs1394824683 983 dbSNP
rs529781886 984 dbSNP
rs1404928769 985 dbSNP
rs1173531172 989 dbSNP
rs1040623808 991 dbSNP
rs1378836257 993 dbSNP
rs1324224748 1004 dbSNP
rs1373484360 1005 dbSNP
rs1441853333 1012 dbSNP
rs757210815 1013 dbSNP
rs1441121521 1015 dbSNP
rs1026040321 1020 dbSNP
rs572558972 1022 dbSNP
rs747854711 1028 dbSNP
rs1318421860 1036 dbSNP
rs994353996 1040 dbSNP
rs142731841 1046 dbSNP
rs1258113413 1047 dbSNP
rs1469554986 1049 dbSNP
rs780236982 1051 dbSNP
rs1041337408 1056 dbSNP
rs543852984 1057 dbSNP
rs1196038871 1063 dbSNP
rs1374144610 1069 dbSNP
rs1352800627 1072 dbSNP
rs889811749 1075 dbSNP
rs1163249720 1078 dbSNP
rs1283582371 1086 dbSNP
rs1049696598 1092 dbSNP
rs977899148 1097 dbSNP
rs1382962549 1098 dbSNP
rs966495192 1104 dbSNP
rs1296309055 1106 dbSNP
rs1341071152 1107 dbSNP
rs1232554200 1112 dbSNP
rs1024863174 1118 dbSNP
rs1291245634 1119 dbSNP
rs1336639103 1120 dbSNP
rs758849977 1123 dbSNP
rs1013445002 1130 dbSNP
rs867579605 1132 dbSNP
rs1054182 1136 dbSNP
rs774905947 1137 dbSNP
rs959661677 1143 dbSNP
rs1206392286 1146 dbSNP
rs1243427737 1147 dbSNP
rs576488284 1155 dbSNP
rs1485647891 1172 dbSNP
rs1033683689 1174 dbSNP
rs1420533000 1175 dbSNP
rs1342793827 1176 dbSNP
rs1314082449 1186 dbSNP
rs1362288438 1190 dbSNP
rs1455491632 1193 dbSNP
rs574873276 1193 dbSNP
rs1399923143 1195 dbSNP
rs1414137048 1196 dbSNP
rs1006751282 1201 dbSNP
rs1357198214 1205 dbSNP
rs1359067360 1205 dbSNP
rs1305951342 1206 dbSNP
rs1314786527 1208 dbSNP
rs887875635 1209 dbSNP
rs1240689290 1211 dbSNP
rs1286154571 1228 dbSNP
rs1047804721 1234 dbSNP
rs746351842 1235 dbSNP
rs1421176949 1239 dbSNP
rs1408181349 1242 dbSNP
rs1483829169 1247 dbSNP
rs1177003761 1248 dbSNP
rs1248804251 1251 dbSNP
rs1162145745 1252 dbSNP
rs901981443 1256 dbSNP
rs1471558336 1260 dbSNP
rs970361976 1261 dbSNP
rs1022865356 1265 dbSNP
rs111383797 1267 dbSNP
rs1448603661 1268 dbSNP
rs1487909372 1270 dbSNP
rs1392819395 1271 dbSNP
rs1260794585 1277 dbSNP
rs951658787 1278 dbSNP
rs186978874 1283 dbSNP
rs1231449456 1292 dbSNP
rs993650660 1293 dbSNP
rs961599904 1299 dbSNP
rs889487142 1304 dbSNP
rs1020187030 1310 dbSNP
rs1250020264 1319 dbSNP
rs1008501847 1321 dbSNP
rs1179559034 1323 dbSNP
rs1252608961 1324 dbSNP
rs1293948293 1333 dbSNP
rs1195600998 1340 dbSNP
rs1425909825 1341 dbSNP
rs757846454 1349 dbSNP
rs1415007880 1356 dbSNP
rs753912674 1366 dbSNP
rs778830175 1375 dbSNP
rs1352600520 1376 dbSNP
rs1466985996 1382 dbSNP
rs1314454121 1384 dbSNP
rs925077695 1387 dbSNP
rs1331715848 1396 dbSNP
rs977784426 1409 dbSNP
rs1049935136 1416 dbSNP
rs1305035733 1419 dbSNP
rs1349652154 1425 dbSNP
rs945241900 1429 dbSNP
rs1294043584 1431 dbSNP
rs1403214838 1433 dbSNP
rs1309701731 1452 dbSNP
rs1011537691 1456 dbSNP
rs1272892773 1458 dbSNP
rs1467333069 1467 dbSNP
rs893138126 1475 dbSNP
rs1053244313 1477 dbSNP
rs753841106 1488 dbSNP
rs1475116842 1493 dbSNP
rs1491350369 1502 dbSNP
rs1417298956 1503 dbSNP
rs551548961 1503 dbSNP
rs1478731671 1504 dbSNP
rs755177573 1508 dbSNP
rs1171158651 1509 dbSNP
rs1164946486 1511 dbSNP
rs1459586466 1512 dbSNP
rs917732968 1513 dbSNP
rs928512935 1513 dbSNP
rs992077321 1514 dbSNP
rs765396582 1521 dbSNP
rs117351669 1527 dbSNP
rs1195592408 1529 dbSNP
rs558587193 1536 dbSNP
rs1033980280 1537 dbSNP
rs1219741670 1551 dbSNP
rs1293102076 1556 dbSNP
rs1333118486 1558 dbSNP
rs984811395 1564 dbSNP
rs533959424 1565 dbSNP
rs1026413690 1566 dbSNP
rs1243873385 1571 dbSNP
rs993566569 1572 dbSNP
rs1453517611 1574 dbSNP
rs1194261512 1579 dbSNP
rs1416959695 1581 dbSNP
rs1273910535 1582 dbSNP
rs902035067 1589 dbSNP
rs1414073677 1594 dbSNP
rs1399706201 1603 dbSNP
rs566564557 1617 dbSNP
rs918917500 1620 dbSNP
rs1019118756 1624 dbSNP
rs971866571 1624 dbSNP
rs1401195789 1627 dbSNP
rs1316613257 1634 dbSNP
rs1008257131 1638 dbSNP
rs1260615407 1639 dbSNP
rs1354027569 1646 dbSNP
rs554632212 1647 dbSNP
rs550366370 1648 dbSNP
rs889380028 1650 dbSNP
rs756251383 1651 dbSNP
rs1285090086 1655 dbSNP
rs766675713 1662 dbSNP
rs1433877843 1668 dbSNP
rs936365104 1668 dbSNP
rs1222242823 1676 dbSNP
rs1018669909 1681 dbSNP
rs1008823427 1698 dbSNP
rs903517882 1703 dbSNP
rs116893419 1707 dbSNP
rs1256715846 1707 dbSNP
rs1189380834 1709 dbSNP
rs565202138 1711 dbSNP
rs1464595678 1727 dbSNP
rs1237796895 1736 dbSNP
rs1397481757 1738 dbSNP
rs3801792 1740 dbSNP
rs1381684966 1741 dbSNP
rs1011777940 1745 dbSNP
rs1172399908 1749 dbSNP
rs1410430918 1760 dbSNP
rs893169307 1762 dbSNP
rs917783763 1767 dbSNP
rs1335314789 1770 dbSNP
rs1189189261 1771 dbSNP
rs1479134159 1772 dbSNP
rs13232520 1781 dbSNP
rs1053511631 1782 dbSNP
rs13232209 1783 dbSNP
rs113682447 1786 dbSNP
rs998844079 1787 dbSNP
rs13246640 1791 dbSNP
rs1178246325 1792 dbSNP
rs759432188 1796 dbSNP
rs1054187 1803 dbSNP
rs1054188 1810 dbSNP
rs1278214599 1811 dbSNP
rs948537387 1812 dbSNP
rs1205891953 1815 dbSNP
rs1279125972 1816 dbSNP
rs1437002816 1818 dbSNP
rs985083822 1820 dbSNP
rs952107158 1825 dbSNP
rs1179300174 1830 dbSNP
rs1312074299 1864 dbSNP
rs915743683 1875 dbSNP
rs1049040455 1876 dbSNP
rs1392682468 1877 dbSNP
rs930531663 1878 dbSNP
rs918952174 1879 dbSNP
rs144247317 1884 dbSNP
rs1408569995 1886 dbSNP
rs1349616347 1895 dbSNP
rs1333707638 1897 dbSNP
rs1401323104 1903 dbSNP
rs1440385725 1916 dbSNP
rs1303765143 1919 dbSNP
rs1332882174 1920 dbSNP
rs1445573588 1926 dbSNP
rs1374065341 1939 dbSNP
rs1235401061 1942 dbSNP
rs1275364557 1944 dbSNP
rs1196539507 1949 dbSNP
rs561165560 1949 dbSNP
rs1259694037 1952 dbSNP
rs531987665 1953 dbSNP
rs966107172 1969 dbSNP
rs570760983 1970 dbSNP
rs1212651299 1972 dbSNP
rs1250656382 1983 dbSNP
rs1434387706 1990 dbSNP
rs1200280819 1995 dbSNP
rs1373014188 1996 dbSNP
rs3801794 1996 dbSNP
rs911636421 2004 dbSNP
rs985898602 2004 dbSNP
rs954247597 2008 dbSNP
rs527854384 2012 dbSNP
rs1471858773 2030 dbSNP
rs1324118721 2033 dbSNP
rs1393053490 2036 dbSNP
rs1358461091 2041 dbSNP
rs1317653307 2042 dbSNP
rs144494679 2042 dbSNP
rs1436422188 2044 dbSNP
rs990386582 2044 dbSNP
rs781688250 2047 dbSNP
rs1007747260 2048 dbSNP
rs1395454776 2050 dbSNP
rs1158316993 2052 dbSNP
rs889256901 2062 dbSNP
rs560558756 2067 dbSNP
rs777186531 2069 dbSNP
rs1000839314 2071 dbSNP
rs1279907247 2073 dbSNP
rs1318311312 2075 dbSNP
rs1232368290 2082 dbSNP
rs1489219725 2088 dbSNP
rs1438041121 2090 dbSNP
rs1209927873 2094 dbSNP
rs1260375985 2112 dbSNP
rs1487612949 2115 dbSNP
rs543103059 2126 dbSNP
rs1196440452 2129 dbSNP
rs1252784337 2130 dbSNP
rs374729401 2131 dbSNP
rs1177811566 2134 dbSNP
rs575811376 2135 dbSNP
rs1042029125 2137 dbSNP
rs1031894016 2144 dbSNP
rs1458558190 2150 dbSNP
rs542289916 2150 dbSNP
rs1236170670 2161 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugccgaucaccuggucCACUUCa 5'
                          |||||| 
Target 5' --------------aaGUGAAGa 3'
1 - 9
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000428084.1 | 3UTR | AAGUGAAGAAAAAAAAAACUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000428084.1 | 3UTR | AAGUGAAGAAAAAAAAAACUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
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138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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