miRTarBase - #MIRT618557


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pre-miRNA Information
pre-miRNA hsa-mir-3152   
Genomic Coordinates chr9: 18573306 - 18573379
Description Homo sapiens miR-3152 stem-loop
Comment Berezikov et al. proposed this sequence as a miRNA candidate based on the RAKE method .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3152-5p
Sequence 11| AUUGCCUCUGUUCUAACACAAG |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1019691326 2 dbSNP
rs1282676806 8 dbSNP
rs762305650 11 dbSNP
rs1364318615 12 dbSNP
rs556364307 18 dbSNP
rs1002755159 19 dbSNP
rs1238555909 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol VLDLR   
Synonyms CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH
Description very low density lipoprotein receptor
Transcript NM_001018056   
Other Transcripts NM_003383   
Expression
Putative miRNA Targets on VLDLR
3'UTR of VLDLR
(miRNA target sites are highlighted)		 
>VLDLR|NM_001018056|3'UTR
   1 CTTCTGTGACAAATGTTGACCTTTGAGGTCTAAACAAATAATACCCCCGTCGGAATGGTAACCGAGCCAGCAGCTGAAGT
  81 CTCTTTTTCTTCCTCTCGGCTGGAAGAACATCAAGATACCTTTGCGTGGATCAAGCTTGTGTACTTGACCGTTTTTATAT
 161 TACTTTTGTAAATATTCTTGTCCACATTCTACTTCAGCTTTGGATGTGGTTACCGAGTATCTGTAACCCTTGAATTTCTA
 241 GACAGTATTGCCACCTCTGGCCAAATATGCACTTTCCCTAGAAAGCCATATTCCAGCAGTGAAACTTGTGCTATAGTGTA
 321 TACCACCTGTACATACATTGTATAGGCCATCTGTAAATATCCCAGAGAACAATCACTATTCTTAAGCACTTTGAAAATAT
 401 TTCTATGTAAATTATTGTAAACTTTTTCAATGGTTGGGACAATGGCAATAGGACAAAACGGGTTACTAAGATGAAATTGC
 481 CAAAAAAATTTATAAACTAATTTTGTACGTATGAATGATATCTTTGACCTCAATGGAGGTTTGCAAAGACTGAGTGTTCA
 561 AACTACTGTACATTTTTTTTCAAGTGCTAAAAAATTAAACCAAGCAGCTTAACCATGGTTTGTGCCTGTTCCTCTAGGAT
 641 GAACTCCTATCCTGAGTAGTACCAAGTGTTCTAACTAAATGTGTGAGCTGTAGTTCTTGATGTTGTATAACTAAGCCTGT
 721 AATTGGGCTGGTTTCTCTTACACCCTAGCACAGTTAAAAAATGAAGTACTGTTTAACATTTGCTCCCGAAATATTTCTTA
 801 CTGTGTAAAAGAAGCTAGCTTAGTCTGTACCTAGAATTCCTCTTGGTTAGAGGAGTGAGTTTCTTTTTTTTCCATTAACT
 881 TGTTTCCTGATCGAGAAACACGTGCTAAGATTTCTATGAATTCTGCTTCTTTATAGTTAAGTCTCTGTTTTCCATGTTCT
 961 GTCATTTATATAGGTCAAGGACAAGTGCCTTCTAAGGCATGGATAAGGGCTTTCTTCTTATGAAAGTCTAGACTGTCTTA
1041 CTGTGAAGATGGCCAGGGAGGATAGCAAGCAATGGCATTCTTGAACAGTCTAAGGCAGGTTTCTCAGTGTGGTCCTGAGA
1121 ACAGAAGCATCTGCATCACCTGGGAATGTATTAGAAATGCAAGTTCCCAGCCCCATCCCAGACCTACTGAATCAGAAACT
1201 CTGGGGGCGAGGGCTGAAACCTGCTTTCATAAGCCCTTCAGGCGATACTGATGTAAACTAAAGCTTAAAAACCACCGTTT
1281 TACTGTGACTTCATGAAGAATATAATTGCAATATCACCTAAATTTTTATCCTGGCTGGGATGGGGCAGATTCTTACTATG
1361 GACAATTTCTGGAACTTACAGTATGAAGAGCAGATGAGGAGTTTGAGACAAAGAAAAAATTGTACAGGGAGTTTAGTGAA
1441 TTTTCCATCAGGTTGGCCATTACTTTCTTTCTCTAAAGTCTCAGGATGTCTGGAAGCAAGGAAAGACAAAAGACTTGAAG
1521 CACCGGGTGCATGCTGTGTGTCACAAGTGAGGTGGAGAGTTGGCTGTGGAAGGTACAGCAATTCCTCTGGAATTAAATGA
1601 CCGACCAACACAGTACCAAGAGGATGAAGAGAAGATGTTTTGCGTTGCTACGTGAATCAGTGGATGACTCATATTTCACT
1681 TGCATATGAAATATAAGGCAGTTAACATCTTGTTTGTGGCTTAAGCAAGGACATTAATCCTACTAGATGAAGGGGAAGTT
1761 GGTTCTGTTGTCTTAAGGGATGCCCCCTTGTGATTTTGGTCAACTGAATGAAAAAGAAAAGATAGCCTTGGACTTTTTTT
1841 TCATGGGAGGTTTGGAGGTCAAGCATGTAGAAGGAAAAGGCTGTAGTCATGAATATAGAACTGTCTGCTCTCCACCTTTT
1921 CCTCACTCTACATTTAGTCATCACACTGAACAGGATGTGGCCTGCTGACAGTGAGTAGCTGAAGTGCCTGTTTGGTAAGT
2001 AGGTTAGCATTCATCATGAACTCTGAAAGCCATTTCAGAGTTTGGCTGCTGCTCTGACCCTGCTGTGGTACAAAAAACAT
2081 GGATTTTTTTTTTTTTAACTGGAGTAATACCAAATTCCCTTTAGAAGCTTGAAGTTTGATACTATTGCTTTCCCCATTAT
2161 AAGGATTATACAGTATTAATTAATTATAAGGCCCAAAGTTTGTTTTGGCAAATAAAGTATTATTCTCTATCATCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaACAC----AAUCUUGUCUCCGUua 5'
            ||||    | |||||||| |||  
Target 5' agTGTGGTCCTGAGAACAGAAGCAtc 3'
 1106 - 1131 126.00 -16.10
2 
miRNA  3' gaACACAAUCUU----GUCUCCGUUa 5'
            ||  | ||||    ::|:|||:| 
Target 5' acTGAATCAGAAACTCTGGGGGCGAg 3'
 1186 - 1211 122.00 -9.90
3 
miRNA  3' gaACACAAUCUUGUCUCCGUUa 5'
            || | |:|:|: |:||||: 
Target 5' ccTG-GCTGGGAT-GGGGCAGa 3'
 1330 - 1349 122.00 -13.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
366375 17 ClinVar
914095 22 ClinVar
914096 46 ClinVar
914097 47 ClinVar
366376 49 ClinVar
914098 52 ClinVar
366377 64 ClinVar
366378 84 ClinVar
914099 99 ClinVar
366379 181 ClinVar
914605 193 ClinVar
914606 215 ClinVar
914607 268 ClinVar
914608 282 ClinVar
914609 352 ClinVar
366380 461 ClinVar
366381 491 ClinVar
366382 518 ClinVar
912642 535 ClinVar
366383 552 ClinVar
366384 593 ClinVar
COSN30179595 5 COSMIC
COSN31519357 20 COSMIC
COSN30507910 42 COSMIC
COSN19613004 44 COSMIC
COSN30633294 50 COSMIC
COSN31577857 53 COSMIC
COSN19669542 65 COSMIC
COSN31612418 68 COSMIC
COSN30525387 74 COSMIC
COSN32078197 77 COSMIC
COSN20091888 95 COSMIC
COSN7564268 99 COSMIC
COSN30506231 100 COSMIC
COSN31552441 127 COSMIC
COSN25386119 132 COSMIC
COSN31497636 152 COSMIC
COSN30606760 253 COSMIC
COSN31608051 404 COSMIC
COSN31538123 490 COSMIC
COSN9708051 545 COSMIC
COSN14961893 552 COSMIC
COSN21130766 602 COSMIC
COSN14697209 750 COSMIC
COSN5243526 778 COSMIC
COSN15824348 968 COSMIC
COSN6386651 1058 COSMIC
COSN2318487 1166 COSMIC
COSN19526037 1249 COSMIC
COSN29339707 1350 COSMIC
COSN17857700 1628 COSMIC
COSN14691556 1653 COSMIC
COSN14948825 1835 COSMIC
COSN16459085 1995 COSMIC
COSN25489361 2095 COSMIC
COSN22062711 2695 COSMIC
COSN21485036 3327 COSMIC
COSN7564278 3496 COSMIC
COSN8582072 3681 COSMIC
COSN14916693 3800 COSMIC
COSN27569447 3870 COSMIC
COSN7564281 3966 COSMIC
COSN14687941 3967 COSMIC
COSN22523444 3968 COSMIC
COSN22276427 4290 COSMIC
COSN14759157 4444 COSMIC
COSN4944920 4663 COSMIC
COSN14903642 4720 COSMIC
COSN25432691 4742 COSMIC
COSN17218045 4883 COSMIC
COSN9708060 4946 COSMIC
COSN23863684 5375 COSMIC
COSN14689401 5413 COSMIC
COSN6386675 5436 COSMIC
COSN22738832 5605 COSMIC
COSN27400675 5672 COSMIC
COSN25030954 5870 COSMIC
COSN6386676 5992 COSMIC
COSN6386677 6176 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780844055 1 dbSNP
rs745715137 2 dbSNP
rs755204149 5 dbSNP
rs748173553 7 dbSNP
rs772294761 9 dbSNP
rs1352918693 10 dbSNP
rs773401239 11 dbSNP
rs1021914190 15 dbSNP
rs747470089 16 dbSNP
rs150475109 17 dbSNP
rs1186398879 20 dbSNP
rs776834603 22 dbSNP
rs138315503 24 dbSNP
rs1276244545 28 dbSNP
rs764827843 30 dbSNP
rs1199131346 32 dbSNP
rs1238873966 33 dbSNP
rs775125623 38 dbSNP
rs770526257 44 dbSNP
rs981955018 44 dbSNP
rs762389751 45 dbSNP
rs920949909 46 dbSNP
rs35412127 47 dbSNP
rs1172417285 48 dbSNP
rs368949453 49 dbSNP
rs199836483 50 dbSNP
rs752035004 52 dbSNP
rs545939033 53 dbSNP
rs1313546735 63 dbSNP
rs17848373 64 dbSNP
rs919730879 65 dbSNP
rs572795512 69 dbSNP
rs1003301427 72 dbSNP
rs1402934226 74 dbSNP
rs541771399 75 dbSNP
rs1163173448 77 dbSNP
rs17848374 78 dbSNP
rs755339168 84 dbSNP
rs1461773445 89 dbSNP
rs184964853 93 dbSNP
rs555501387 95 dbSNP
rs1057182493 96 dbSNP
rs759431817 98 dbSNP
rs543466401 99 dbSNP
rs560904917 103 dbSNP
rs1022215330 106 dbSNP
rs563773271 107 dbSNP
rs554880815 113 dbSNP
rs1250916132 115 dbSNP
rs767511235 126 dbSNP
rs568081586 127 dbSNP
rs1267136256 130 dbSNP
rs1336176181 133 dbSNP
rs1247130108 134 dbSNP
rs1315178236 141 dbSNP
rs953717472 142 dbSNP
rs113664587 144 dbSNP
rs1447833966 150 dbSNP
rs781591405 151 dbSNP
rs1324368355 152 dbSNP
rs532501452 160 dbSNP
rs552762400 168 dbSNP
rs951889021 169 dbSNP
rs984685497 178 dbSNP
rs1452206105 180 dbSNP
rs3421 181 dbSNP
rs1158656321 185 dbSNP
rs1019257052 192 dbSNP
rs763576733 193 dbSNP
rs1373181242 201 dbSNP
rs1197984258 203 dbSNP
rs961421220 208 dbSNP
rs1224718066 209 dbSNP
rs922954322 212 dbSNP
rs189180202 215 dbSNP
rs1240891223 216 dbSNP
rs1050203799 218 dbSNP
rs771892744 221 dbSNP
rs1233047403 240 dbSNP
rs972485995 245 dbSNP
rs919764976 247 dbSNP
rs947563687 249 dbSNP
rs931145865 253 dbSNP
rs1036108012 268 dbSNP
rs1298337955 269 dbSNP
rs1420979514 273 dbSNP
rs1041946199 275 dbSNP
rs1171613363 276 dbSNP
rs1442539674 277 dbSNP
rs1379185055 279 dbSNP
rs753515879 282 dbSNP
rs181124390 307 dbSNP
rs938720343 310 dbSNP
rs1057070703 317 dbSNP
rs894514946 323 dbSNP
rs756800891 330 dbSNP
rs1200129735 333 dbSNP
rs778568814 338 dbSNP
rs1276989444 348 dbSNP
rs747325781 348 dbSNP
rs1225686549 363 dbSNP
rs1027029195 365 dbSNP
rs951858363 366 dbSNP
rs1006478692 370 dbSNP
rs946143542 379 dbSNP
rs1413823763 382 dbSNP
rs1353043361 388 dbSNP
rs1332885043 402 dbSNP
rs1479325430 404 dbSNP
rs1014787664 405 dbSNP
rs1043117407 406 dbSNP
rs755387235 408 dbSNP
rs962249220 409 dbSNP
rs904718960 413 dbSNP
rs922921671 414 dbSNP
rs568676349 431 dbSNP
rs1403143189 433 dbSNP
rs1443272700 434 dbSNP
rs1280988717 440 dbSNP
rs1197184790 441 dbSNP
rs537023295 442 dbSNP
rs953029940 443 dbSNP
rs996328755 449 dbSNP
rs1029288387 455 dbSNP
rs781642188 460 dbSNP
rs550310153 461 dbSNP
rs570489084 463 dbSNP
rs1443492169 467 dbSNP
rs947187684 469 dbSNP
rs1290741458 484 dbSNP
rs1344097876 490 dbSNP
rs886063812 491 dbSNP
rs1223251884 494 dbSNP
rs1282299948 495 dbSNP
rs766384966 495 dbSNP
rs961042815 498 dbSNP
rs972920694 504 dbSNP
rs1026715034 509 dbSNP
rs139291322 510 dbSNP
rs979896845 513 dbSNP
rs1205853996 515 dbSNP
rs1057324468 516 dbSNP
rs886063813 518 dbSNP
rs1457449337 519 dbSNP
rs1489809954 521 dbSNP
rs927096376 521 dbSNP
rs1239175793 522 dbSNP
rs186510684 523 dbSNP
rs1200847803 531 dbSNP
rs1320501040 533 dbSNP
rs1198390522 534 dbSNP
rs10967349 535 dbSNP
rs948741691 542 dbSNP
rs577276181 545 dbSNP
rs1377111961 552 dbSNP
rs8210 552 dbSNP
rs888514271 554 dbSNP
rs1438442071 560 dbSNP
rs555206503 561 dbSNP
rs1166245387 564 dbSNP
rs558443957 565 dbSNP
rs1430486346 573 dbSNP
rs946056943 574 dbSNP
rs368338996 575 dbSNP
rs1156856101 576 dbSNP
rs1439330986 578 dbSNP
rs1364233837 581 dbSNP
rs1381137966 588 dbSNP
rs1404750244 588 dbSNP
rs897689174 589 dbSNP
rs886063814 593 dbSNP
rs543752005 594 dbSNP
rs1246442013 597 dbSNP
rs1331326144 597 dbSNP
rs1234886222 600 dbSNP
rs563541312 601 dbSNP
rs1268029960 609 dbSNP
rs1453766996 617 dbSNP
rs575430367 620 dbSNP
rs1238777368 629 dbSNP
rs1030273971 632 dbSNP
rs1050585526 633 dbSNP
rs546366143 638 dbSNP
rs770969904 640 dbSNP
rs1021326219 641 dbSNP
rs544483119 642 dbSNP
rs1036600085 644 dbSNP
rs896834892 647 dbSNP
rs1296485265 653 dbSNP
rs1419167928 657 dbSNP
rs1221471032 663 dbSNP
rs571398869 666 dbSNP
rs938866158 667 dbSNP
rs993844223 671 dbSNP
rs1027183713 676 dbSNP
rs1424911883 680 dbSNP
rs993016445 692 dbSNP
rs952473841 694 dbSNP
rs916177512 698 dbSNP
rs1215315934 708 dbSNP
rs1267719340 709 dbSNP
rs1488316940 709 dbSNP
rs1287474589 710 dbSNP
rs1207622234 720 dbSNP
rs372282344 724 dbSNP
rs1279082254 742 dbSNP
rs1191389856 744 dbSNP
rs773111986 744 dbSNP
rs34318472 750 dbSNP
rs1277451113 752 dbSNP
rs771016012 759 dbSNP
rs1450224899 762 dbSNP
rs888491673 765 dbSNP
rs368949537 767 dbSNP
rs993182884 768 dbSNP
rs1177336928 769 dbSNP
rs1416492985 770 dbSNP
rs1424508053 771 dbSNP
rs1037124962 772 dbSNP
rs1164210443 773 dbSNP
rs913130236 774 dbSNP
rs1193598069 788 dbSNP
rs967823197 789 dbSNP
rs1264708958 791 dbSNP
rs1179547363 794 dbSNP
rs372042145 794 dbSNP
rs997366488 795 dbSNP
rs1237689321 798 dbSNP
rs1315832535 802 dbSNP
rs528663080 803 dbSNP
rs978779055 804 dbSNP
rs1315810589 806 dbSNP
rs1363981775 813 dbSNP
rs1222381611 817 dbSNP
rs1435215780 819 dbSNP
rs925906128 826 dbSNP
rs1219175058 832 dbSNP
rs191750546 835 dbSNP
rs1030201792 845 dbSNP
rs1245230901 853 dbSNP
rs889019983 854 dbSNP
rs1265959164 860 dbSNP
rs932072443 861 dbSNP
rs1303626229 862 dbSNP
rs1454733703 862 dbSNP
rs138703857 864 dbSNP
rs529664460 864 dbSNP
rs1021702283 870 dbSNP
rs1358254964 872 dbSNP
rs374506353 873 dbSNP
rs1283856567 877 dbSNP
rs1465484960 880 dbSNP
rs1190595441 882 dbSNP
rs912093395 883 dbSNP
rs1241287194 887 dbSNP
rs1162164564 888 dbSNP
rs944836179 892 dbSNP
rs1037058457 893 dbSNP
rs1183268863 894 dbSNP
rs1456125038 896 dbSNP
rs1237358963 901 dbSNP
rs1188929711 902 dbSNP
rs562360717 903 dbSNP
rs1243521333 906 dbSNP
rs1452146003 908 dbSNP
rs183154872 911 dbSNP
rs550542363 926 dbSNP
rs1048063095 927 dbSNP
rs1248446972 927 dbSNP
rs888091312 946 dbSNP
rs1331162100 955 dbSNP
rs759380723 956 dbSNP
rs186161453 959 dbSNP
rs1031437532 962 dbSNP
rs1001255205 964 dbSNP
rs960168561 971 dbSNP
rs992942759 972 dbSNP
rs1292268555 975 dbSNP
rs1457801551 976 dbSNP
rs1034051176 977 dbSNP
rs771804729 987 dbSNP
rs879865598 993 dbSNP
rs1437500380 1000 dbSNP
rs767458424 1001 dbSNP
rs1394916256 1004 dbSNP
rs959888836 1006 dbSNP
rs978922498 1010 dbSNP
rs1179069497 1012 dbSNP
rs916102395 1013 dbSNP
rs1313414335 1019 dbSNP
rs1020655585 1021 dbSNP
rs35790034 1023 dbSNP
rs967321893 1031 dbSNP
rs1266120429 1033 dbSNP
rs979061892 1033 dbSNP
rs550841513 1035 dbSNP
rs1308760084 1036 dbSNP
rs373457435 1036 dbSNP
rs775562911 1048 dbSNP
rs1241389993 1049 dbSNP
rs1337924160 1051 dbSNP
rs1299562170 1052 dbSNP
rs1386720772 1053 dbSNP
rs953345299 1054 dbSNP
rs1210881115 1067 dbSNP
rs1261489253 1070 dbSNP
rs1460957694 1073 dbSNP
rs1359561001 1078 dbSNP
rs986235028 1085 dbSNP
rs909837952 1091 dbSNP
rs940037093 1097 dbSNP
rs1197825624 1104 dbSNP
rs539127839 1113 dbSNP
rs1201731658 1114 dbSNP
rs1487335719 1123 dbSNP
rs1037497340 1128 dbSNP
rs1258902785 1130 dbSNP
rs1417810876 1131 dbSNP
rs546320846 1132 dbSNP
rs34067270 1136 dbSNP
rs369023562 1140 dbSNP
rs1332220058 1143 dbSNP
rs535243155 1145 dbSNP
rs34600018 1147 dbSNP
rs1339319786 1148 dbSNP
rs1298197928 1149 dbSNP
rs190924724 1154 dbSNP
rs1399590036 1160 dbSNP
rs1171851866 1162 dbSNP
rs183390323 1163 dbSNP
rs1049751678 1165 dbSNP
rs888143738 1167 dbSNP
rs936990084 1172 dbSNP
rs1055509134 1177 dbSNP
rs867505416 1179 dbSNP
rs536503994 1181 dbSNP
rs531805664 1182 dbSNP
rs1168474322 1194 dbSNP
rs904164378 1198 dbSNP
rs998544604 1203 dbSNP
rs1014389058 1205 dbSNP
rs371908484 1209 dbSNP
rs1020133878 1210 dbSNP
rs374165873 1214 dbSNP
rs1013997818 1216 dbSNP
rs1217346660 1217 dbSNP
rs1317780369 1221 dbSNP
rs1278338546 1224 dbSNP
rs1023079241 1228 dbSNP
rs1229965383 1229 dbSNP
rs1000143461 1244 dbSNP
rs750117106 1245 dbSNP
rs1410491375 1247 dbSNP
rs1408066965 1248 dbSNP
rs1168189259 1251 dbSNP
rs1424245341 1254 dbSNP
rs953397628 1254 dbSNP
rs1168609526 1255 dbSNP
rs986122011 1267 dbSNP
rs557321026 1277 dbSNP
rs966155565 1278 dbSNP
rs910152512 1280 dbSNP
rs577196338 1284 dbSNP
rs961962195 1287 dbSNP
rs1234095066 1290 dbSNP
rs972535454 1295 dbSNP
rs546235547 1312 dbSNP
rs1479691327 1318 dbSNP
rs1195795779 1319 dbSNP
rs1274282118 1320 dbSNP
rs922635983 1320 dbSNP
rs930794092 1321 dbSNP
rs187724521 1329 dbSNP
rs926877797 1337 dbSNP
rs1049848257 1338 dbSNP
rs1353669577 1340 dbSNP
rs542403273 1349 dbSNP
rs1245073232 1358 dbSNP
rs1384527473 1366 dbSNP
rs1055397461 1369 dbSNP
rs192498586 1370 dbSNP
rs949841813 1373 dbSNP
rs1176179405 1374 dbSNP
rs1041843351 1375 dbSNP
rs903037764 1376 dbSNP
rs548447556 1378 dbSNP
rs1000434716 1380 dbSNP
rs1032962633 1382 dbSNP
rs1445525725 1385 dbSNP
rs889044386 1386 dbSNP
rs1177206915 1387 dbSNP
rs1007442052 1392 dbSNP
rs1439451190 1394 dbSNP
rs34287778 1397 dbSNP
rs1207282503 1401 dbSNP
rs1450323325 1404 dbSNP
rs1288543431 1408 dbSNP
rs552284046 1410 dbSNP
rs1222578182 1422 dbSNP
rs1361201580 1428 dbSNP
rs966413053 1430 dbSNP
rs993626603 1432 dbSNP
rs1377400755 1433 dbSNP
rs895517553 1435 dbSNP
rs1411452661 1446 dbSNP
rs1013922975 1447 dbSNP
rs1349211522 1458 dbSNP
rs1301019203 1460 dbSNP
rs1022671624 1463 dbSNP
rs1367175090 1468 dbSNP
rs781596773 1469 dbSNP
rs1179262093 1480 dbSNP
rs1477364737 1481 dbSNP
rs1026798987 1483 dbSNP
rs1490703136 1486 dbSNP
rs1283210609 1487 dbSNP
rs952288254 1488 dbSNP
rs1005707765 1494 dbSNP
rs1286151440 1498 dbSNP
rs148499851 1501 dbSNP
rs1283826228 1504 dbSNP
rs1406645751 1515 dbSNP
rs961649623 1519 dbSNP
rs926761581 1522 dbSNP
rs1347503611 1525 dbSNP
rs183275434 1533 dbSNP
rs1276007346 1534 dbSNP
rs1344891132 1535 dbSNP
rs1399645231 1558 dbSNP
rs973430860 1569 dbSNP
rs959620240 1570 dbSNP
rs992339683 1573 dbSNP
rs1489001454 1574 dbSNP
rs1191481869 1580 dbSNP
rs916947943 1585 dbSNP
rs985519586 1590 dbSNP
rs1192280433 1591 dbSNP
rs1268987174 1603 dbSNP
rs1426272213 1604 dbSNP
rs1243463002 1606 dbSNP
rs532730607 1607 dbSNP
rs1207820479 1610 dbSNP
rs1041504731 1618 dbSNP
rs1390744870 1630 dbSNP
rs35218736 1632 dbSNP
rs924347472 1632 dbSNP
rs935702340 1636 dbSNP
rs1315927004 1643 dbSNP
rs1054291647 1644 dbSNP
rs978599159 1645 dbSNP
rs7040916 1653 dbSNP
rs1290875515 1655 dbSNP
rs934586762 1672 dbSNP
rs576972284 1674 dbSNP
rs1337734262 1676 dbSNP
rs1471273794 1680 dbSNP
rs1295555071 1684 dbSNP
rs553871236 1685 dbSNP
rs1169393199 1687 dbSNP
rs1040303243 1689 dbSNP
rs1420971070 1693 dbSNP
rs1179789664 1702 dbSNP
rs1298330852 1707 dbSNP
rs1367986258 1708 dbSNP
rs1205316862 1710 dbSNP
rs1243544992 1710 dbSNP
rs1456441375 1711 dbSNP
rs1257320917 1724 dbSNP
rs901867282 1727 dbSNP
rs1244488786 1734 dbSNP
rs1228002311 1743 dbSNP
rs1289792594 1752 dbSNP
rs1322744701 1754 dbSNP
rs1297728160 1759 dbSNP
rs778371722 1768 dbSNP
rs1226833356 1771 dbSNP
rs1382289428 1779 dbSNP
rs1224212079 1781 dbSNP
rs895443917 1783 dbSNP
rs528964554 1790 dbSNP
rs1463239202 1793 dbSNP
rs749274673 1794 dbSNP
rs755429132 1799 dbSNP
rs1462911962 1805 dbSNP
rs1355778616 1812 dbSNP
rs1248043909 1815 dbSNP
rs1162024388 1818 dbSNP
rs1422939775 1820 dbSNP
rs1044094369 1830 dbSNP
rs1450789457 1831 dbSNP
rs1181720962 1834 dbSNP
rs1437617150 1834 dbSNP
rs905603351 1834 dbSNP
rs35456336 1835 dbSNP
rs34458671 1841 dbSNP
rs1253201144 1844 dbSNP
rs959517595 1845 dbSNP
rs575456244 1850 dbSNP
rs1359037941 1854 dbSNP
rs76436428 1858 dbSNP
rs753089829 1872 dbSNP
rs1248391874 1876 dbSNP
rs918158464 1881 dbSNP
rs377083877 1890 dbSNP
rs1392495434 1894 dbSNP
rs1376153829 1897 dbSNP
rs1291353382 1899 dbSNP
rs1423422588 1899 dbSNP
rs971120711 1901 dbSNP
rs977498674 1902 dbSNP
rs1029939035 1903 dbSNP
rs924260307 1905 dbSNP
rs746157857 1906 dbSNP
rs955330759 1910 dbSNP
rs985444370 1914 dbSNP
rs35299644 1916 dbSNP
rs1189591605 1917 dbSNP
rs771977967 1926 dbSNP
rs1284180688 1932 dbSNP
rs571588977 1933 dbSNP
rs1230420726 1938 dbSNP
rs1225014651 1949 dbSNP
rs968157439 1961 dbSNP
rs1351710283 1963 dbSNP
rs1260567849 1964 dbSNP
rs910416507 1965 dbSNP
rs1305225493 1974 dbSNP
rs796211945 1980 dbSNP
rs1404836769 1989 dbSNP
rs1345596924 1995 dbSNP
rs1304369895 2003 dbSNP
rs979958214 2008 dbSNP
rs1040331159 2014 dbSNP
rs1326657936 2017 dbSNP
rs1158968355 2024 dbSNP
rs901751542 2025 dbSNP
rs539798708 2027 dbSNP
rs1375676194 2030 dbSNP
rs925773422 2031 dbSNP
rs1048197471 2037 dbSNP
rs1207781603 2053 dbSNP
rs1269717774 2060 dbSNP
rs1201669862 2071 dbSNP
rs1268335732 2072 dbSNP
rs988663514 2077 dbSNP
rs1206143460 2084 dbSNP
rs1254563142 2084 dbSNP
rs562529797 2084 dbSNP
rs58675279 2084 dbSNP
rs775367045 2085 dbSNP
rs1006289268 2098 dbSNP
rs1033705673 2100 dbSNP
rs1216217316 2103 dbSNP
rs553414022 2105 dbSNP
rs941088138 2105 dbSNP
rs1383520928 2109 dbSNP
rs1473045652 2111 dbSNP
rs895355530 2119 dbSNP
rs756418302 2120 dbSNP
rs1470298043 2132 dbSNP
rs573366225 2139 dbSNP
rs897298866 2144 dbSNP
rs1372535313 2145 dbSNP
rs1013697077 2146 dbSNP
rs1194173512 2160 dbSNP
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rs1241745008 2170 dbSNP
rs1203425843 2171 dbSNP
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rs781385402 2175 dbSNP
rs1391082637 2191 dbSNP
rs1338220002 2192 dbSNP
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rs1338325590 2203 dbSNP
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rs58045872 2209 dbSNP
rs1329256432 2210 dbSNP
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rs1163333686 2996 dbSNP
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rs1290933950 2999 dbSNP
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rs1036998643 4529 dbSNP
rs1003427991 4533 dbSNP
rs1335569608 4541 dbSNP
rs916282824 4549 dbSNP
rs180984727 4553 dbSNP
rs930357405 4557 dbSNP
rs113514585 4561 dbSNP
rs1280303512 4562 dbSNP
rs1444823273 4564 dbSNP
rs1195934248 4565 dbSNP
rs931424288 4569 dbSNP
rs1044466532 4571 dbSNP
rs940853603 4580 dbSNP
rs765817446 4584 dbSNP
rs1003035576 4585 dbSNP
rs1156310265 4586 dbSNP
rs902073561 4588 dbSNP
rs77213939 4589 dbSNP
rs1476935050 4591 dbSNP
rs747798643 4597 dbSNP
rs1376802206 4599 dbSNP
rs548134596 4601 dbSNP
rs560300233 4602 dbSNP
rs751007785 4604 dbSNP
rs967694350 4612 dbSNP
rs903307111 4614 dbSNP
rs1384180641 4617 dbSNP
rs538594207 4619 dbSNP
rs999297487 4626 dbSNP
rs1320204560 4628 dbSNP
rs1303091741 4630 dbSNP
rs367833509 4631 dbSNP
rs1000641960 4637 dbSNP
rs1338532609 4639 dbSNP
rs1319060685 4641 dbSNP
rs1413886343 4643 dbSNP
rs558593348 4655 dbSNP
rs1337135099 4658 dbSNP
rs1028071863 4659 dbSNP
rs1412374522 4669 dbSNP
rs77874861 4670 dbSNP
rs541172081 4672 dbSNP
rs1455377323 4688 dbSNP
rs1388258165 4690 dbSNP
rs766540870 4692 dbSNP
rs1023685284 4703 dbSNP
rs1218261550 4709 dbSNP
rs1254662740 4710 dbSNP
rs961287138 4711 dbSNP
rs1212058673 4717 dbSNP
rs1442232935 4718 dbSNP
rs11790283 4720 dbSNP
rs574608250 4724 dbSNP
rs1257789978 4725 dbSNP
rs1445438871 4742 dbSNP
rs1374491788 4743 dbSNP
rs1475951514 4746 dbSNP
rs543268267 4747 dbSNP
rs1436393431 4748 dbSNP
rs1156490886 4749 dbSNP
rs1410434776 4753 dbSNP
rs907610051 4753 dbSNP
rs940443681 4756 dbSNP
rs563571513 4760 dbSNP
rs1044907934 4762 dbSNP
rs532283996 4765 dbSNP
rs938724750 4766 dbSNP
rs544992145 4767 dbSNP
rs772915370 4768 dbSNP
rs1057318905 4772 dbSNP
rs564984832 4775 dbSNP
rs1010521749 4778 dbSNP
rs947403400 4780 dbSNP
rs1043312057 4783 dbSNP
rs1354228153 4787 dbSNP
rs1041725124 4797 dbSNP
rs903562336 4800 dbSNP
rs1000530290 4801 dbSNP
rs527756726 4804 dbSNP
rs1297390412 4805 dbSNP
rs1442910446 4810 dbSNP
rs375187021 4815 dbSNP
rs547902871 4816 dbSNP
rs1162518877 4820 dbSNP
rs1403705293 4822 dbSNP
rs1417189917 4831 dbSNP
rs1165982426 4832 dbSNP
rs767512808 4834 dbSNP
rs1476290201 4837 dbSNP
rs747893895 4838 dbSNP
rs1357114206 4841 dbSNP
rs1177005085 4846 dbSNP
rs1028374844 4847 dbSNP
rs889548405 4850 dbSNP
rs1008371626 4852 dbSNP
rs1219946936 4864 dbSNP
rs1333581248 4868 dbSNP
rs1273237609 4869 dbSNP
rs1234823414 4870 dbSNP
rs1326624957 4874 dbSNP
rs1305775795 4885 dbSNP
rs1019431896 4886 dbSNP
rs961174337 4891 dbSNP
rs1291736063 4893 dbSNP
rs1393882750 4896 dbSNP
rs1440051140 4896 dbSNP
rs972662190 4899 dbSNP
rs1026850411 4904 dbSNP
rs952596146 4905 dbSNP
rs1326654286 4907 dbSNP
rs4741754 4908 dbSNP
rs749287478 4909 dbSNP
rs1012557226 4916 dbSNP
rs938793943 4919 dbSNP
rs993309263 4920 dbSNP
rs1190024476 4921 dbSNP
rs146905297 4922 dbSNP
rs946196436 4926 dbSNP
rs961780330 4933 dbSNP
rs76195380 4936 dbSNP
rs570293136 4937 dbSNP
rs1318549783 4946 dbSNP
rs991500184 4954 dbSNP
rs923395114 4955 dbSNP
rs1249321625 4957 dbSNP
rs772712333 4961 dbSNP
rs953589011 4962 dbSNP
rs375725405 4963 dbSNP
rs539383563 4975 dbSNP
rs552201362 4976 dbSNP
rs1375872187 4977 dbSNP
rs1454476132 4979 dbSNP
rs1172150793 4984 dbSNP
rs369278899 4987 dbSNP
rs889434355 4991 dbSNP
rs565709941 4992 dbSNP
rs184826630 4993 dbSNP
rs537877078 4994 dbSNP
rs1041692533 4996 dbSNP
rs1205395149 5005 dbSNP
rs993969235 5009 dbSNP
rs1254084162 5010 dbSNP
rs865828274 5015 dbSNP
rs371989686 5021 dbSNP
rs1282415317 5024 dbSNP
rs1226057429 5030 dbSNP
rs1324803509 5044 dbSNP
rs1393223650 5046 dbSNP
rs1383046943 5047 dbSNP
rs554615876 5049 dbSNP
rs980397970 5050 dbSNP
rs1311219839 5053 dbSNP
rs938730466 5058 dbSNP
rs1370320431 5059 dbSNP
rs1376392691 5061 dbSNP
rs1057238052 5066 dbSNP
rs1460887863 5073 dbSNP
rs1372064163 5078 dbSNP
rs896281803 5082 dbSNP
rs1034383517 5085 dbSNP
rs1012071161 5087 dbSNP
rs1186724916 5088 dbSNP
rs1045322413 5090 dbSNP
rs1282160910 5105 dbSNP
rs1203020745 5107 dbSNP
rs574469940 5115 dbSNP
rs992967669 5118 dbSNP
rs1228250978 5119 dbSNP
rs1306232801 5122 dbSNP
rs1006173766 5125 dbSNP
rs1414374527 5126 dbSNP
rs1356544941 5128 dbSNP
rs1315170599 5129 dbSNP
rs775303728 5130 dbSNP
rs1396423984 5136 dbSNP
rs1414994429 5142 dbSNP
rs946081995 5142 dbSNP
rs537203362 5143 dbSNP
rs1475329251 5150 dbSNP
rs1259425442 5156 dbSNP
rs868139081 5158 dbSNP
rs765764291 5160 dbSNP
rs139204125 5161 dbSNP
rs1250417943 5163 dbSNP
rs1197434869 5168 dbSNP
rs1030093177 5170 dbSNP
rs1271316928 5177 dbSNP
rs1232972981 5179 dbSNP
rs576722326 5180 dbSNP
rs545719373 5185 dbSNP
rs1237338834 5188 dbSNP
rs1335499118 5197 dbSNP
rs1330210562 5203 dbSNP
rs986314209 5204 dbSNP
rs564920144 5205 dbSNP
rs1461455723 5208 dbSNP
rs968907715 5208 dbSNP
rs1419578543 5217 dbSNP
rs1453231783 5218 dbSNP
rs1156406538 5226 dbSNP
rs1194236132 5230 dbSNP
rs1396761217 5232 dbSNP
rs1447470723 5234 dbSNP
rs932267993 5236 dbSNP
rs1183954092 5246 dbSNP
rs1467078568 5248 dbSNP
rs1373875948 5249 dbSNP
rs1463774741 5251 dbSNP
rs1213155727 5255 dbSNP
rs1468915849 5256 dbSNP
rs1051095673 5257 dbSNP
rs1203595246 5259 dbSNP
rs549849553 5267 dbSNP
rs1280504657 5268 dbSNP
rs1241882669 5269 dbSNP
rs73640157 5270 dbSNP
rs1328553809 5272 dbSNP
rs948854684 5279 dbSNP
rs1040652730 5281 dbSNP
rs1395970304 5283 dbSNP
rs1214359671 5285 dbSNP
rs761122189 5286 dbSNP
rs1296809646 5291 dbSNP
rs887615451 5293 dbSNP
rs541086991 5298 dbSNP
rs896910972 5307 dbSNP
rs1309627655 5315 dbSNP
rs865927464 5316 dbSNP
rs561383723 5322 dbSNP
rs10812407 5328 dbSNP
rs1454804532 5329 dbSNP
rs888264523 5331 dbSNP
rs997178328 5334 dbSNP
rs1001483533 5341 dbSNP
rs1285150536 5342 dbSNP
rs554025598 5350 dbSNP
rs1213731290 5351 dbSNP
rs960103071 5355 dbSNP
rs1007730474 5360 dbSNP
rs1369156241 5361 dbSNP
rs1254819218 5363 dbSNP
rs1267891084 5365 dbSNP
rs751621629 5370 dbSNP
rs968878232 5372 dbSNP
rs143231037 5374 dbSNP
rs575724717 5375 dbSNP
rs1031873001 5380 dbSNP
rs960305531 5386 dbSNP
rs1417365825 5391 dbSNP
rs992838517 5399 dbSNP
rs1167118237 5403 dbSNP
rs1184871699 5406 dbSNP
rs915929782 5407 dbSNP
rs978815402 5410 dbSNP
rs1947447 5413 dbSNP
rs150422409 5414 dbSNP
rs1484922835 5415 dbSNP
rs552940315 5425 dbSNP
rs1212310344 5426 dbSNP
rs986431850 5429 dbSNP
rs1394599511 5444 dbSNP
rs80084157 5451 dbSNP
rs138201217 5460 dbSNP
rs1339424554 5461 dbSNP
rs1279719236 5462 dbSNP
rs547879912 5473 dbSNP
rs1354659154 5476 dbSNP
rs1313252743 5479 dbSNP
rs1416336953 5479 dbSNP
rs527894757 5484 dbSNP
rs1333619542 5491 dbSNP
rs1409478017 5503 dbSNP
rs1233383769 5510 dbSNP
rs1274568524 5514 dbSNP
rs755896075 5518 dbSNP
rs1173140853 5525 dbSNP
rs1474346769 5537 dbSNP
rs1215037357 5540 dbSNP
rs568138743 5551 dbSNP
rs1417667762 5552 dbSNP
rs189438512 5555 dbSNP
rs558506764 5558 dbSNP
rs1185445573 5563 dbSNP
rs1231702447 5567 dbSNP
rs1204375809 5575 dbSNP
rs547745419 5577 dbSNP
rs777599091 5579 dbSNP
rs117600007 5580 dbSNP
rs1333725464 5586 dbSNP
rs1190320095 5588 dbSNP
rs1007287370 5590 dbSNP
rs888326067 5598 dbSNP
rs1297591553 5604 dbSNP
rs1442795051 5611 dbSNP
rs1401206049 5613 dbSNP
rs904312269 5626 dbSNP
rs1459887058 5630 dbSNP
rs1417416017 5631 dbSNP
rs1165871560 5635 dbSNP
rs1001767560 5643 dbSNP
rs1177205226 5647 dbSNP
rs1031842007 5653 dbSNP
rs1055599606 5654 dbSNP
rs1464864103 5664 dbSNP
rs993493798 5672 dbSNP
rs1467606768 5674 dbSNP
rs1312591332 5675 dbSNP
rs1314951090 5678 dbSNP
rs765428009 5678 dbSNP
rs750564225 5679 dbSNP
rs753642014 5682 dbSNP
rs1415094552 5688 dbSNP
rs1379041346 5689 dbSNP
rs1020312923 5690 dbSNP
rs376966707 5695 dbSNP
rs539263305 5705 dbSNP
rs1438838692 5709 dbSNP
rs1393764629 5713 dbSNP
rs1370606284 5716 dbSNP
rs181352825 5719 dbSNP
rs1284872756 5722 dbSNP
rs1459639281 5727 dbSNP
rs1343864257 5730 dbSNP
rs1158859086 5741 dbSNP
rs374621553 5745 dbSNP
rs1382735349 5746 dbSNP
rs538105963 5751 dbSNP
rs1453321751 5754 dbSNP
rs541372396 5758 dbSNP
rs1208618067 5761 dbSNP
rs1192631775 5765 dbSNP
rs1484680532 5767 dbSNP
rs909955525 5780 dbSNP
rs940109591 5782 dbSNP
rs1278127862 5783 dbSNP
rs1355531644 5783 dbSNP
rs971883887 5787 dbSNP
rs114235648 5795 dbSNP
rs1302057188 5798 dbSNP
rs1231344489 5803 dbSNP
rs1360145580 5818 dbSNP
rs1288474899 5823 dbSNP
rs1420718531 5825 dbSNP
rs1469718625 5829 dbSNP
rs1177790207 5831 dbSNP
rs778745304 5833 dbSNP
rs1172361209 5834 dbSNP
rs1434641089 5837 dbSNP
rs933212623 5839 dbSNP
rs1410820425 5840 dbSNP
rs574875176 5841 dbSNP
rs1052134258 5845 dbSNP
rs1177620320 5848 dbSNP
rs1426153916 5849 dbSNP
rs544257690 5851 dbSNP
rs1186693992 5852 dbSNP
rs149598158 5853 dbSNP
rs966278963 5855 dbSNP
rs745333559 5860 dbSNP
rs1210152658 5864 dbSNP
rs771523085 5865 dbSNP
rs533133558 5870 dbSNP
rs1235556978 5875 dbSNP
rs1305790843 5876 dbSNP
rs1295188778 5877 dbSNP
rs1400804904 5878 dbSNP
rs1314357891 5882 dbSNP
rs998593371 5884 dbSNP
rs1053179920 5896 dbSNP
rs1414486927 5902 dbSNP
rs929636822 5904 dbSNP
rs144231060 5905 dbSNP
rs1023651062 5906 dbSNP
rs1279684074 5915 dbSNP
rs532719150 5921 dbSNP
rs1374866673 5925 dbSNP
rs746718260 5927 dbSNP
rs1415139156 5928 dbSNP
rs1186968237 5929 dbSNP
rs1442752117 5939 dbSNP
rs577025540 5943 dbSNP
rs1232038187 5944 dbSNP
rs185916809 5951 dbSNP
rs961420491 5954 dbSNP
rs1348351168 5960 dbSNP
rs1212702105 5961 dbSNP
rs1271154984 5964 dbSNP
rs972815511 5970 dbSNP
rs190683385 5979 dbSNP
rs528792271 5983 dbSNP
rs1331459401 5986 dbSNP
rs1466674718 5987 dbSNP
rs76255110 6001 dbSNP
rs1391881283 6011 dbSNP
rs1163703199 6013 dbSNP
rs1473032331 6016 dbSNP
rs1056046497 6017 dbSNP
rs1418420822 6021 dbSNP
rs895624266 6027 dbSNP
rs949969569 6028 dbSNP
rs1041651746 6031 dbSNP
rs1467172607 6032 dbSNP
rs148717572 6035 dbSNP
rs181905942 6037 dbSNP
rs1209438337 6039 dbSNP
rs78330356 6051 dbSNP
rs934369864 6054 dbSNP
rs1052819551 6056 dbSNP
rs889214257 6067 dbSNP
rs1243243868 6072 dbSNP
rs1409074182 6079 dbSNP
rs1329076753 6080 dbSNP
rs1007620424 6085 dbSNP
rs570110347 6089 dbSNP
rs1368128496 6097 dbSNP
rs1324850643 6098 dbSNP
rs1405591084 6111 dbSNP
rs550225442 6113 dbSNP
rs115677005 6114 dbSNP
rs1156610581 6115 dbSNP
rs1452695604 6125 dbSNP
rs1380872506 6126 dbSNP
rs1371551591 6127 dbSNP
rs1044591756 6128 dbSNP
rs972322784 6132 dbSNP
rs142621194 6136 dbSNP
rs1005815415 6137 dbSNP
rs1215421256 6159 dbSNP
rs146034443 6160 dbSNP
rs566417001 6161 dbSNP
rs961389936 6164 dbSNP
rs1287426222 6172 dbSNP
rs1332799772 6182 dbSNP
rs535432769 6186 dbSNP
rs375851315 6188 dbSNP
rs113172866 6189 dbSNP
rs143910176 6189 dbSNP
rs34869606 6189 dbSNP
rs369064604 6189 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084074. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202481. RNA binding protein: AGO2. Condition:S6_LV_61yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000382100.3 | 3UTR | UACAAGGCAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084074
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SantaCruzAb
Location of target site ENST00000382100.3 | 3UTR | CAAGGCAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000382100.3 | 3UTR | CAAGGCAAAAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
75 hsa-miR-3152-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092535 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT461731 NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 2 2
MIRT468456 SET SET nuclear proto-oncogene 2 2
MIRT482192 AHR aryl hydrocarbon receptor 2 2
MIRT507923 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT512208 C18orf25 chromosome 18 open reading frame 25 2 6
MIRT526238 STARD4 StAR related lipid transfer domain containing 4 2 2
MIRT536131 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536280 LIMA1 LIM domain and actin binding 1 2 2
MIRT544251 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT548054 GOLGA7 golgin A7 2 2
MIRT563443 ISCA1 iron-sulfur cluster assembly 1 2 2
MIRT565643 SIX4 SIX homeobox 4 2 2
MIRT614870 PDE12 phosphodiesterase 12 2 2
MIRT614923 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT615793 FAM124A family with sequence similarity 124 member A 2 2
MIRT618557 VLDLR very low density lipoprotein receptor 2 2
MIRT622147 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT622390 RSBN1 round spermatid basic protein 1 2 2
MIRT624185 DDX19B DEAD-box helicase 19B 2 2
MIRT624448 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT625340 TAPBP TAP binding protein 2 2
MIRT625370 IRGQ immunity related GTPase Q 2 2
MIRT627276 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT627746 RAD54L2 RAD54 like 2 2 2
MIRT629578 RFC2 replication factor C subunit 2 2 4
MIRT630537 LGALS8 galectin 8 2 4
MIRT630559 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT630568 SOWAHA sosondowah ankyrin repeat domain family member A 2 4
MIRT630763 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT635424 LRP10 LDL receptor related protein 10 2 2
MIRT636011 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT636337 PHAX phosphorylated adaptor for RNA export 2 2
MIRT638413 POU3F2 POU class 3 homeobox 2 2 2
MIRT639358 INIP INTS3 and NABP interacting protein 2 2
MIRT642124 DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A 2 4
MIRT642828 KIAA0319 KIAA0319 2 2
MIRT644017 NUCB1 nucleobindin 1 2 2
MIRT644038 WWC2 WW and C2 domain containing 2 2 2
MIRT644153 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644649 SNX9 sorting nexin 9 2 2
MIRT645798 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT647633 FAIM2 Fas apoptotic inhibitory molecule 2 2 2
MIRT648528 KIAA1143 KIAA1143 2 2
MIRT648851 PDLIM3 PDZ and LIM domain 3 2 2
MIRT648880 TUBGCP5 tubulin gamma complex associated protein 5 2 2
MIRT650777 TNFRSF10A TNF receptor superfamily member 10a 2 2
MIRT654200 RNF19B ring finger protein 19B 2 2
MIRT654508 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT655249 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT656089 MTA3 metastasis associated 1 family member 3 2 2
MIRT656599 LRRC55 leucine rich repeat containing 55 2 2
MIRT659194 CYBB cytochrome b-245 beta chain 2 2
MIRT660000 C1orf115 chromosome 1 open reading frame 115 2 4
MIRT661715 KLF8 Kruppel like factor 8 2 2
MIRT661813 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT668360 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT679734 CABP4 calcium binding protein 4 2 2
MIRT708616 NUDT18 nudix hydrolase 18 2 2
MIRT709034 TROVE2 TROVE domain family member 2 2 2
MIRT709573 DMGDH dimethylglycine dehydrogenase 2 2
MIRT709665 AJAP1 adherens junctions associated protein 1 2 2
MIRT709874 TRAF1 TNF receptor associated factor 1 2 2
MIRT710821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT710883 PARL presenilin associated rhomboid like 2 2
MIRT711547 LCAT lecithin-cholesterol acyltransferase 2 2
MIRT712017 STX1B syntaxin 1B 2 2
MIRT713058 BLVRA biliverdin reductase A 2 2
MIRT713129 THRB thyroid hormone receptor beta 2 2
MIRT713878 MOB3A MOB kinase activator 3A 2 2
MIRT714154 NXPH3 neurexophilin 3 2 2
MIRT719755 FLYWCH1 FLYWCH-type zinc finger 1 2 2
MIRT720213 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT722728 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT725652 ABI2 abl interactor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)

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