pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol GREB1   
Synonyms -
Description growth regulation by estrogen in breast cancer 1
Transcript NM_014668   
Other Transcripts NM_033090 , NM_148903   
Expression
Putative miRNA Targets on GREB1
3'UTR of GREB1
(miRNA target sites are highlighted)
>GREB1|NM_014668|3'UTR
   1 GGAAGACAGCGGCGAGTTTTCTGAAGAGATGAGTGCTCAGAGCCCTCATGCTGTTGAGGCTAAAGGGAGGCCTGGAACGG
  81 TGGGGCGTTTGACTGGAATGGACCCCAGGGACTGTCCAGGTGCAGCCCCTCCTAGTACACATGGGCCCCCGAGGCCGTGG
 161 TCCTGGGAGCCAGGAAGACTCCGCAGTGGGTGAGAATGAAAACTTGAGACTCCCAAGTTCTGGGCCAGCCCATTGCTCTG
 241 GGCTGTTTTAAAGCCCATTTCACGAGGAACAAAGATTTACTTCCTGTCCTGCCATTCGTGTGCTTCCATGGACAAACCTG
 321 ATTTTTTTCTCTTAGTTCTAAAGAATCTTGGGTTATTTTGTAGCGGTGCCAGTATTTCAGTAGATGGGATTTCAGCCAAG
 401 TAGGTTCCCCTGTAACCTCCTACAAAGCAATATTCCAAAGGAACATTTTAACTGTAAAGGCTGGAGACAAGAAAAAATAA
 481 GTAGATCGTTTTAATAACAATTATTTAATTGCCTATAAGTTTGCTGTTTCAGAGGCTAGCCCAAAGGCATCAAATTTAAT
 561 AAAGTTAAACAAATTGATTTACTTCAGAGCAAATATGATCCTATTAAAATAATATAGGGTAAATACCCTACCTCTTAGAA
 641 AGGGCAAAAATGCAAAGAAGCTTTCTTTAAAACTAAAAGGGTTTTTTGGGGGGGGAGTTGGCGGGGAGGAAATAAGGCTA
 721 ACAGAGGTTGACCTAAAATTAGCCTTACAAAGGAGAAAGGACCACATTGCTTACTTGAAACAGACAATGAAAACAACCAA
 801 AGTGATATATAAAATAGTTGATGAGAACTAGACTTATGACTGTAGTTTACTAGAGTTTAGTTTTCAGTTGCTGAAGTAGC
 881 TCATTTTCTCTTACTAATGTTTGGTTCCTCAGGGAAGAATCTCACTTGACTAGAGAGGAGGTGGGAACAGAAGAGAGAAG
 961 GAGGCAGGGAGATGTATTTCTTAGGGCTCACCCCTTCACAGACTGACAGAATGGTTTTGTTTTGTTTTGTTTTGTTTTGT
1041 TTTGTTTTTGAGATGGACTCTAGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCGCC
1121 TCCCGGGTTCTCACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTAATT
1201 TTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGC
1281 CTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGCCCCAGAATGGTTTTTAAAGCCACAGTTGAGA
1361 GGCCACCCATTGCCCGGCGCCTGGACAGTGATCATCTTGTTCATCTTGTTCAGTCCTTTCTTGTGTGATTGGAATTATTC
1441 ATCCCCTTTGAAAGATGAGAAGGTTGAGATGCAAAGAGTCTACCTTTCCAAGTTCTCACTGCTGGAAAGAGCTAGAAGCA
1521 CAGTTCAAAGTTCTGGCTTCTGGACTCTGCAGTCCAGGTCTCCCTTCTCCCACTTGCCTACCCTCAATGCCACACTGTTT
1601 TTGAAGTGGCCCATAACTTGAAGGAAAAGTTTAAAGACAGTTCAATTTAATCATCAGAATGCATTCTTTTTTTTTTCGGA
1681 GACGGAGTTTCACTCTTGCTGCCCAGGCTGGAGTGCAATGGTGCAATGACCTCGGCTCACTGCAACCTCTGCCTCCTGGG
1761 TTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTATGGGCGCCCACCACCATGCCCAGCTAATTTTTGTAT
1841 TTTTTTTTTTTAGTAGAGATGGGGTTTCGCCAGGTTGGCCAGGCTGGTCTTGTGAACTCCTGGCCTCAGGTGATCTGCCC
1921 ACCTCATCCTCCAAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCTGGCCTCAGAATGCATTCTTACACATCTATCC
2001 TAGACATTTATAAGCACTCTAATGGATAACAATCCAAGAATAAATGATTGTAAAAGATGATGCCGAAGAGTTGATGTCAA
2081 TCTTTTTTTCCTAAGAAAAAAAGTCCGCGAGTATTAAATATTTAGATCAATGTTTATAAAATGATTACTTTGTATATCTC
2161 ATTATTCCTATTTTGGAATAAAAACTGACCTTCTTTAATCATATACTTGTCTTTTGTAAATAGCAGCTTTTGTGTCATTC
2241 TCCCCACTTTATTAGTTAATTTAAATTGGAAAAAACCCTCAAACTAATATTCTTGTCTGTTCCAGTCTTATAAATAAAAC
2321 TTATAATGCATG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' augCGGUCAGUUAUGGAACACu 5'
             ||||| | : ::|||||| 
Target 5' ttgGCCAGGCTG-GTCTTGTGa 3'
1875 - 1895 142.00 -18.90
2
miRNA  3' augcGGUCAGUUAUGGAACACu 5'
              :|||||  | :|||||| 
Target 5' ttgtTCAGTC-CTTTCTTGTGt 3'
1406 - 1426 141.00 -15.60
3
miRNA  3' augCGGUCAGUUAUGGAACAcu 5'
             | |||| |  |:|||||  
Target 5' ctgGACAGTGATCATCTTGTtc 3'
1381 - 1402 127.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30159606 22 COSMIC
COSN30146401 24 COSMIC
COSN32052576 24 COSMIC
COSN30178682 32 COSMIC
COSN30146418 45 COSMIC
COSN30452213 45 COSMIC
COSN30178621 54 COSMIC
COSN30464972 67 COSMIC
COSN32055770 87 COSMIC
COSN28874554 110 COSMIC
COSN31511930 120 COSMIC
COSN30479691 133 COSMIC
COSN30447448 182 COSMIC
COSN30537791 194 COSMIC
COSN6675691 246 COSMIC
COSN21205725 288 COSMIC
COSN30386775 330 COSMIC
COSN25874547 473 COSMIC
COSN32065320 541 COSMIC
COSN20096351 688 COSMIC
COSN22786637 696 COSMIC
COSN18008255 895 COSMIC
COSN20096353 1049 COSMIC
COSN27291748 1049 COSMIC
COSN21215570 1254 COSMIC
COSN24210468 1332 COSMIC
COSN32160921 2066 COSMIC
rs149940960 1039 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1380662734 2 dbSNP
rs1245241804 8 dbSNP
rs1238990298 10 dbSNP
rs1275224800 11 dbSNP
rs770784463 12 dbSNP
rs1193808096 13 dbSNP
rs1271888648 14 dbSNP
rs1281121680 17 dbSNP
rs965365208 19 dbSNP
rs774303607 27 dbSNP
rs370744520 29 dbSNP
rs759464749 30 dbSNP
rs767562192 37 dbSNP
rs1241677272 43 dbSNP
rs1244728281 49 dbSNP
rs1308046766 59 dbSNP
rs1444054001 71 dbSNP
rs1408065246 79 dbSNP
rs953575877 80 dbSNP
rs1008954725 84 dbSNP
rs1441600713 86 dbSNP
rs1380946853 88 dbSNP
rs1269776664 94 dbSNP
rs116203897 97 dbSNP
rs552440860 105 dbSNP
rs1211248633 107 dbSNP
rs1281840759 108 dbSNP
rs1277082629 110 dbSNP
rs182581268 114 dbSNP
rs1353823316 121 dbSNP
rs138649257 125 dbSNP
rs909345368 127 dbSNP
rs1380811263 128 dbSNP
rs779231316 131 dbSNP
rs1055336584 132 dbSNP
rs868045077 133 dbSNP
rs926409371 137 dbSNP
rs918143493 139 dbSNP
rs1338682989 143 dbSNP
rs111641132 145 dbSNP
rs1299990132 146 dbSNP
rs745916080 147 dbSNP
rs368426768 148 dbSNP
rs939194677 149 dbSNP
rs1418164083 151 dbSNP
rs1416223074 152 dbSNP
rs550216094 156 dbSNP
rs1056259236 158 dbSNP
rs568437803 169 dbSNP
rs1488612712 170 dbSNP
rs1488862800 183 dbSNP
rs535799803 184 dbSNP
rs1213804837 188 dbSNP
rs902204793 192 dbSNP
rs936386865 196 dbSNP
rs1427019833 200 dbSNP
rs1354036833 205 dbSNP
rs1279783944 211 dbSNP
rs1053477533 215 dbSNP
rs1038429036 221 dbSNP
rs889569320 227 dbSNP
rs898180069 235 dbSNP
rs1351886421 239 dbSNP
rs1007135537 246 dbSNP
rs1019467493 254 dbSNP
rs772298655 256 dbSNP
rs1412078208 258 dbSNP
rs866757445 264 dbSNP
rs1398982561 267 dbSNP
rs566939297 269 dbSNP
rs994112323 271 dbSNP
rs1009067993 275 dbSNP
rs1019147260 280 dbSNP
rs539254500 281 dbSNP
rs1259820313 282 dbSNP
rs1219009914 290 dbSNP
rs1438961157 293 dbSNP
rs950703244 294 dbSNP
rs187092696 296 dbSNP
rs1345330291 298 dbSNP
rs1022693751 314 dbSNP
rs1410854195 315 dbSNP
rs1294115971 321 dbSNP
rs1436038996 322 dbSNP
rs1016354528 323 dbSNP
rs959507511 327 dbSNP
rs1333863118 328 dbSNP
rs35329446 338 dbSNP
rs769266137 342 dbSNP
rs1349172510 359 dbSNP
rs1221520777 361 dbSNP
rs1423299966 361 dbSNP
rs981062267 361 dbSNP
rs1283017251 365 dbSNP
rs191892159 366 dbSNP
rs1224300941 371 dbSNP
rs1239586177 377 dbSNP
rs540019799 401 dbSNP
rs918103496 402 dbSNP
rs529260559 408 dbSNP
rs183631109 409 dbSNP
rs978315178 410 dbSNP
rs537511300 412 dbSNP
rs1302137054 420 dbSNP
rs1234469241 436 dbSNP
rs936334512 444 dbSNP
rs1369118814 445 dbSNP
rs555760414 461 dbSNP
rs765926256 477 dbSNP
rs188567953 483 dbSNP
rs939742308 484 dbSNP
rs1414677384 486 dbSNP
rs1360248128 489 dbSNP
rs142756030 496 dbSNP
rs1452008401 503 dbSNP
rs1161851725 504 dbSNP
rs1365225501 509 dbSNP
rs1041248970 513 dbSNP
rs1236146084 514 dbSNP
rs919553777 514 dbSNP
rs113656858 516 dbSNP
rs1255305616 521 dbSNP
rs994046821 541 dbSNP
rs1345861116 542 dbSNP
rs1288173382 543 dbSNP
rs1241173074 548 dbSNP
rs1376424987 550 dbSNP
rs1305396757 557 dbSNP
rs1398125433 560 dbSNP
rs1025558138 565 dbSNP
rs200348064 567 dbSNP
rs889353229 569 dbSNP
rs572203272 578 dbSNP
rs944969748 587 dbSNP
rs193208720 588 dbSNP
rs564239493 589 dbSNP
rs1418767618 598 dbSNP
rs1278411091 607 dbSNP
rs865811326 608 dbSNP
rs569357256 619 dbSNP
rs1010025330 620 dbSNP
rs1022386606 626 dbSNP
rs759008406 640 dbSNP
rs1489199610 645 dbSNP
rs1265503586 646 dbSNP
rs1217430312 662 dbSNP
rs1353313752 670 dbSNP
rs531865988 681 dbSNP
rs1247198472 682 dbSNP
rs1312370588 682 dbSNP
rs55829945 682 dbSNP
rs797002756 682 dbSNP
rs1413488204 683 dbSNP
rs1205532700 687 dbSNP
rs1491325407 687 dbSNP
rs1002205148 688 dbSNP
rs1016299933 688 dbSNP
rs1491220734 688 dbSNP
rs3792031 689 dbSNP
rs150738252 690 dbSNP
rs529276529 691 dbSNP
rs970929655 692 dbSNP
rs1446478464 693 dbSNP
rs547821323 694 dbSNP
rs1384785278 695 dbSNP
rs765740786 699 dbSNP
rs1309423942 700 dbSNP
rs3838571 700 dbSNP
rs1389561651 701 dbSNP
rs3792030 703 dbSNP
rs745887582 703 dbSNP
rs924195537 704 dbSNP
rs1170877327 708 dbSNP
rs539702598 717 dbSNP
rs932416619 719 dbSNP
rs985130326 720 dbSNP
rs1409871719 722 dbSNP
rs1335382931 735 dbSNP
rs936950816 736 dbSNP
rs1434046681 737 dbSNP
rs1252572956 743 dbSNP
rs551571786 745 dbSNP
rs1361434356 750 dbSNP
rs1459385065 753 dbSNP
rs1259033992 761 dbSNP
rs865875793 774 dbSNP
rs1195749991 776 dbSNP
rs1454053733 781 dbSNP
rs1276179867 787 dbSNP
rs1233302026 795 dbSNP
rs1330203056 798 dbSNP
rs912245542 799 dbSNP
rs910903168 802 dbSNP
rs188011506 809 dbSNP
rs761827659 816 dbSNP
rs914038369 821 dbSNP
rs537575918 838 dbSNP
rs1404260108 839 dbSNP
rs1174424919 842 dbSNP
rs922378393 854 dbSNP
rs1394503184 867 dbSNP
rs1191993596 868 dbSNP
rs3792029 871 dbSNP
rs1239235238 877 dbSNP
rs1181536983 879 dbSNP
rs1436619963 897 dbSNP
rs866152661 909 dbSNP
rs888351364 922 dbSNP
rs1201479871 927 dbSNP
rs1346567344 933 dbSNP
rs1277486002 934 dbSNP
rs1241887200 939 dbSNP
rs1377165821 941 dbSNP
rs1278807452 948 dbSNP
rs574398601 951 dbSNP
rs1279163307 956 dbSNP
rs1334768203 956 dbSNP
rs903916602 965 dbSNP
rs1462612197 968 dbSNP
rs1002726061 975 dbSNP
rs139156500 976 dbSNP
rs1381121845 986 dbSNP
rs1158401965 993 dbSNP
rs553449313 1010 dbSNP
rs1242683846 1012 dbSNP
rs10639159 1014 dbSNP
rs1353484349 1014 dbSNP
rs1414157647 1014 dbSNP
rs1427973180 1014 dbSNP
rs200595687 1014 dbSNP
rs56312031 1014 dbSNP
rs114300393 1015 dbSNP
rs1366022742 1015 dbSNP
rs1317947157 1016 dbSNP
rs546092942 1019 dbSNP
rs1371574457 1020 dbSNP
rs1438724993 1021 dbSNP
rs752302309 1025 dbSNP
rs564302789 1027 dbSNP
rs72385146 1027 dbSNP
rs1173532349 1029 dbSNP
rs1408866404 1030 dbSNP
rs1488344406 1030 dbSNP
rs1468753311 1036 dbSNP
rs1452964928 1039 dbSNP
rs149940960 1039 dbSNP
rs1232422006 1040 dbSNP
rs1290416027 1040 dbSNP
rs1404786478 1041 dbSNP
rs1332649470 1042 dbSNP
rs1435218818 1042 dbSNP
rs191366001 1043 dbSNP
rs1280049081 1044 dbSNP
rs776594455 1046 dbSNP
rs376922017 1048 dbSNP
rs1219126290 1055 dbSNP
rs1362758809 1059 dbSNP
rs961632269 1063 dbSNP
rs62118341 1064 dbSNP
rs529322801 1070 dbSNP
rs1327037843 1071 dbSNP
rs183724524 1072 dbSNP
rs953794025 1080 dbSNP
rs1418244341 1084 dbSNP
rs985633395 1084 dbSNP
rs545217521 1086 dbSNP
rs139996482 1091 dbSNP
rs551633396 1093 dbSNP
rs569958439 1094 dbSNP
rs1383302385 1095 dbSNP
rs531008475 1095 dbSNP
rs989710317 1096 dbSNP
rs925454248 1098 dbSNP
rs910840239 1100 dbSNP
rs1212845756 1101 dbSNP
rs549122085 1102 dbSNP
rs1440395083 1104 dbSNP
rs1055145997 1109 dbSNP
rs1259829026 1111 dbSNP
rs568159474 1114 dbSNP
rs1167765728 1117 dbSNP
rs976861158 1118 dbSNP
rs1200009933 1119 dbSNP
rs922357567 1121 dbSNP
rs1452125339 1125 dbSNP
rs535167919 1126 dbSNP
rs1480289781 1127 dbSNP
rs1479724355 1128 dbSNP
rs1176278415 1131 dbSNP
rs1013540038 1132 dbSNP
rs1413387742 1133 dbSNP
rs1037019955 1134 dbSNP
rs1233861572 1141 dbSNP
rs1345973187 1142 dbSNP
rs1046898720 1157 dbSNP
rs909733015 1158 dbSNP
rs1372993607 1160 dbSNP
rs897057396 1164 dbSNP
rs1450735139 1166 dbSNP
rs995842850 1167 dbSNP
rs1172462756 1172 dbSNP
rs1432549294 1176 dbSNP
rs1381742314 1177 dbSNP
rs1382312888 1178 dbSNP
rs1381370529 1181 dbSNP
rs553751884 1182 dbSNP
rs188473678 1187 dbSNP
rs1402892828 1189 dbSNP
rs867528817 1190 dbSNP
rs1019364846 1191 dbSNP
rs181426243 1193 dbSNP
rs1329776806 1194 dbSNP
rs1241201007 1223 dbSNP
rs186947420 1226 dbSNP
rs575004501 1235 dbSNP
rs906616755 1238 dbSNP
rs988457636 1243 dbSNP
rs1271351505 1244 dbSNP
rs912915914 1252 dbSNP
rs999578823 1253 dbSNP
rs1361863237 1254 dbSNP
rs1031105082 1255 dbSNP
rs574840209 1257 dbSNP
rs1475532067 1268 dbSNP
rs989869701 1273 dbSNP
rs958203816 1275 dbSNP
rs1185648096 1276 dbSNP
rs966957326 1277 dbSNP
rs1199152870 1279 dbSNP
rs543645576 1280 dbSNP
rs190032161 1284 dbSNP
rs964667860 1285 dbSNP
rs1336170957 1291 dbSNP
rs976431772 1299 dbSNP
rs1361604016 1302 dbSNP
rs922273860 1306 dbSNP
rs951084711 1312 dbSNP
rs569384078 1313 dbSNP
rs982529370 1316 dbSNP
rs917984924 1317 dbSNP
rs574093060 1322 dbSNP
rs1295120750 1323 dbSNP
rs1422440236 1327 dbSNP
rs1472098689 1330 dbSNP
rs1162708877 1334 dbSNP
rs1036964450 1336 dbSNP
rs1373949272 1350 dbSNP
rs540037434 1362 dbSNP
rs1193990073 1366 dbSNP
rs1428187371 1368 dbSNP
rs941164333 1376 dbSNP
rs1195676230 1377 dbSNP
rs1469211357 1378 dbSNP
rs991773039 1379 dbSNP
rs541135993 1380 dbSNP
rs1335297556 1388 dbSNP
rs950040591 1391 dbSNP
rs889742764 1396 dbSNP
rs1046366773 1398 dbSNP
rs1357573434 1402 dbSNP
rs1302999004 1403 dbSNP
rs1441103819 1408 dbSNP
rs1019482686 1416 dbSNP
rs1323636248 1424 dbSNP
rs900906982 1442 dbSNP
rs1397091797 1449 dbSNP
rs1275886872 1457 dbSNP
rs1481890366 1461 dbSNP
rs906562738 1464 dbSNP
rs935379456 1474 dbSNP
rs1461563651 1476 dbSNP
rs551656358 1477 dbSNP
rs1019923043 1483 dbSNP
rs893928307 1485 dbSNP
rs1454830140 1490 dbSNP
rs1250459219 1496 dbSNP
rs747157477 1498 dbSNP
rs1011055771 1499 dbSNP
rs533139804 1500 dbSNP
rs968790644 1502 dbSNP
rs978485976 1512 dbSNP
rs1018887157 1519 dbSNP
rs1183671819 1523 dbSNP
rs1251900920 1540 dbSNP
rs900053343 1543 dbSNP
rs11551693 1557 dbSNP
rs998862621 1558 dbSNP
rs1281772091 1559 dbSNP
rs1234648705 1560 dbSNP
rs182259738 1563 dbSNP
rs951032758 1569 dbSNP
rs563644130 1570 dbSNP
rs982477034 1577 dbSNP
rs1301034243 1586 dbSNP
rs1448694906 1588 dbSNP
rs1336074673 1595 dbSNP
rs531072157 1604 dbSNP
rs78964314 1612 dbSNP
rs962478477 1614 dbSNP
rs918098398 1625 dbSNP
rs949447854 1633 dbSNP
rs1395688771 1637 dbSNP
rs991327535 1656 dbSNP
rs1394670104 1659 dbSNP
rs1172217157 1663 dbSNP
rs1453394230 1666 dbSNP
rs1181739066 1667 dbSNP
rs201717386 1667 dbSNP
rs542274856 1667 dbSNP
rs972796126 1667 dbSNP
rs1259091998 1669 dbSNP
rs915744946 1678 dbSNP
rs117350314 1679 dbSNP
rs1245577295 1681 dbSNP
rs981768301 1684 dbSNP
rs529013698 1685 dbSNP
rs889681979 1687 dbSNP
rs935327153 1694 dbSNP
rs1202896881 1697 dbSNP
rs1251176608 1701 dbSNP
rs1415451146 1704 dbSNP
rs1374887083 1706 dbSNP
rs1483871537 1707 dbSNP
rs1311297648 1713 dbSNP
rs1052408622 1719 dbSNP
rs1244514968 1721 dbSNP
rs1459673769 1724 dbSNP
rs893877669 1727 dbSNP
rs1182650602 1728 dbSNP
rs4669759 1731 dbSNP
rs146790300 1734 dbSNP
rs140462313 1735 dbSNP
rs900001033 1740 dbSNP
rs1254685438 1741 dbSNP
rs904312629 1746 dbSNP
rs1372417902 1747 dbSNP
rs998413748 1761 dbSNP
rs1029911111 1778 dbSNP
rs887396289 1779 dbSNP
rs1003864447 1787 dbSNP
rs1338749715 1790 dbSNP
rs1034049813 1791 dbSNP
rs1404068495 1801 dbSNP
rs560867356 1805 dbSNP
rs142882217 1810 dbSNP
rs569974971 1811 dbSNP
rs1289623383 1816 dbSNP
rs1364352377 1817 dbSNP
rs1345982376 1831 dbSNP
rs1166286634 1840 dbSNP
rs1318138461 1840 dbSNP
rs201367057 1840 dbSNP
rs537305260 1840 dbSNP
rs1461324082 1841 dbSNP
rs1022761216 1853 dbSNP
rs1187758544 1855 dbSNP
rs1197120071 1860 dbSNP
rs1475559463 1862 dbSNP
rs866557066 1869 dbSNP
rs1190514971 1870 dbSNP
rs866763567 1873 dbSNP
rs981276883 1890 dbSNP
rs1295381298 1891 dbSNP
rs187310772 1898 dbSNP
rs1225930692 1903 dbSNP
rs955983524 1905 dbSNP
rs918663013 1906 dbSNP
rs988071935 1911 dbSNP
rs1269865932 1916 dbSNP
rs952848564 1921 dbSNP
rs915259248 1922 dbSNP
rs1202489648 1924 dbSNP
rs573730444 1926 dbSNP
rs1486677273 1929 dbSNP
rs1171961537 1933 dbSNP
rs868731505 1935 dbSNP
rs1418114180 1939 dbSNP
rs1165806458 1942 dbSNP
rs1040985424 1943 dbSNP
rs922394189 1945 dbSNP
rs1253467129 1953 dbSNP
rs1192743224 1954 dbSNP
rs1467122460 1957 dbSNP
rs945861306 1960 dbSNP
rs1040200962 1964 dbSNP
rs541547292 1966 dbSNP
rs921392257 1967 dbSNP
rs1178446540 1974 dbSNP
rs1304679452 1980 dbSNP
rs1427157591 2002 dbSNP
rs1440598252 2006 dbSNP
rs1469292843 2009 dbSNP
rs767214190 2011 dbSNP
rs553191065 2013 dbSNP
rs577669805 2025 dbSNP
rs1353476545 2033 dbSNP
rs934149234 2036 dbSNP
rs1055847881 2037 dbSNP
rs1395290163 2043 dbSNP
rs1172578619 2048 dbSNP
rs1347168416 2057 dbSNP
rs1051290779 2066 dbSNP
rs1409808706 2069 dbSNP
rs1288622681 2073 dbSNP
rs887344479 2079 dbSNP
rs1480258615 2080 dbSNP
rs1004482257 2081 dbSNP
rs1203067371 2083 dbSNP
rs1486804042 2085 dbSNP
rs1281332912 2092 dbSNP
rs138952807 2096 dbSNP
rs545012850 2103 dbSNP
rs778213833 2107 dbSNP
rs1012636507 2108 dbSNP
rs1285970196 2109 dbSNP
rs1416116318 2110 dbSNP
rs1375481371 2112 dbSNP
rs1311904317 2113 dbSNP
rs1023130639 2120 dbSNP
rs1284429070 2121 dbSNP
rs751963583 2125 dbSNP
rs538348494 2129 dbSNP
rs1346803193 2137 dbSNP
rs1213276853 2148 dbSNP
rs920830339 2153 dbSNP
rs984240131 2157 dbSNP
rs753026682 2161 dbSNP
rs1002647342 2165 dbSNP
rs1031477233 2190 dbSNP
rs2117730 2206 dbSNP
rs73915453 2228 dbSNP
rs1480101117 2231 dbSNP
rs1177844675 2233 dbSNP
rs1262910843 2239 dbSNP
rs915211308 2243 dbSNP
rs968445005 2244 dbSNP
rs975478766 2245 dbSNP
rs1287040185 2248 dbSNP
rs1235613908 2252 dbSNP
rs542930754 2253 dbSNP
rs934093225 2259 dbSNP
rs1158593816 2266 dbSNP
rs976782357 2270 dbSNP
rs1051237102 2276 dbSNP
rs1393990373 2277 dbSNP
rs908730003 2305 dbSNP
rs946014647 2312 dbSNP
rs1041913333 2315 dbSNP
rs1167015406 2316 dbSNP
rs1461843070 2325 dbSNP
rs756960190 2328 dbSNP
rs151053697 2331 dbSNP
rs898784743 2332 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' augCGGUCAGUUAUGGAACAcu 5'
             |:::| ||:   || ||  
Target 5' cagGUUGGCCAGG--CUGGUcu 3'
3 - 22
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000381486.2 | 3UTR | GCCAGGUUGGCCAGGCUGGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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