pre-miRNA Information
pre-miRNA hsa-mir-6509   
Genomic Coordinates chr7: 135206994 - 135207078
Description Homo sapiens miR-6509 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6509-3p
Sequence 52| UUCCACUGCCACUACCUAAUUU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778601614 1 dbSNP
rs754554776 3 dbSNP
rs767798995 3 dbSNP
rs145322812 4 dbSNP
rs773941257 5 dbSNP
rs768273593 9 dbSNP
rs984565062 12 dbSNP
rs748872915 13 dbSNP
rs774861125 14 dbSNP
rs13241975 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NOS1AP   
Synonyms 6330408P19Rik, CAPON
Description nitric oxide synthase 1 adaptor protein
Transcript NM_001126060   
Other Transcripts NM_001164757 , NM_014697   
Expression
Putative miRNA Targets on NOS1AP
3'UTR of NOS1AP
(miRNA target sites are highlighted)
>NOS1AP|NM_001126060|3'UTR
   1 GTGCCGAGGGCGAGGAGATGGAGGCGGCGGCGTGGCTGGAGGGGCCGTGTCTGGCTGCTGCCCGGGTAGGGGATGCCCAG
  81 TGAATGTGCACTGCCGAGGAGAATGCCAGCCAGGGCCCGGGAGAGTGTGAGGTTTCAGGAAAGTATTGAGATTCTGCTTT
 161 GGAGGGTAAAGTGGGGAAGAAATCGGATTCCCAGAGGTGAATCAGCTCCTCTCCTACTTGTGACTAGAGGGTGGTGGAGG
 241 TAAGGCCTTCCAGAGCCCATGGCTTCAGGAGAGGGTCTCTCTCCAGGACTGCCAGGCTGCTGGAGGACCTGCCCCTACCT
 321 GCTGCATCGTCAGGCTCCCACGCTTTGTCCGTGATGCCCCCCTACCCCCTCACTCTCCCCGTCTCCATGGTCCCGACCAG
 401 GAAGGGAAGCCATCGGTACCTTCTCAGGTACTTTGTTTCTGGATATCACGATGCTGCGAGTTGCCTAACCCTCCCCCTAC
 481 CTTTATGAGAGGAATTCCTTCTCCAGGCCCTTGCTGAGATTGTAGAGATTGAGTGCTCTGGACCGCAAAAGCCAGGCTAG
 561 TCCTTGTAGGGTGAGCATGGAATTGGAATGTGTCACAGTGGATAAGCTTTTAGAGGAACTGAATCCAAACATTTTCTCCA
 641 GCCGGACATTGAATGTTGCTACAAAGGGAGCCTTGAAGCTTTAACATGGTTCAGGCCCTTGGTGTGAGAGCCCAGGGGGA
 721 GGACAGCTTGTCTGCTGCTCCAAATCACTTAGATCTGATTCCTGTTTTGAAAGTCCTGCCCTGCCTTCCTCCTGCCTGTA
 801 GCCCAGCCCATCTAAATGGAAGCTGGGAATTGCCCCTCACCTCCCCTGTGTCCTGTCCAGCTGAAGCTTTTGCAGCACTT
 881 TACCTCTCTGAAAGCCCCAGAGGACCAGAGCCCCCAGCCTTACCTCTCAACCTGTCCCCTCCACTGGGCAGTGGTGGTCA
 961 GTTTTTACTGCAAAAAAAAAAAAAGAAAAAAGAGAAAGAAAAAAAAGAATGAATGCAAGCTGATAGCTGAGACTGTGAGA
1041 CTGTTTTTGTCCACTCTTCTGAATCACTGCCACTTGGGTCAGGGACCACAGCCATTGCCACCCTTGGCCCATCTCTCTGC
1121 GTGCGTGCCTTGAGCACACATATAAAAAGTGCCATGTGCAATTGTCTTATCTTTTATGATCTAGGCTTTGCCTAGGGATC
1201 ACTACTCCTTAACGGGCTGGCTGGGGCAATGAGGAAAAGCTCCTTTGCTCCTGTAAGGCCATAAGTGGCTGTTAACAGAT
1281 TTTCAAATGCCTGAAGAGATTGCTGAGACCTGCTAGAGTCATATGTTCGGGGAATTAAGTCTTTATCCTAGACAACAAGG
1361 TACAGATGCAAACTGCAGTGTTATTGGAGGGTCAATCGGCAAGGATATGATTATCCCAAAATGGAGTTCATCGACCCTAG
1441 CTTTCCTTTAGATTATATATAAATAAAAGTGCAGTCCTCTTCTAATGGCCACAGTTGGTTTTCTTGTAGCCCAGAAAGTC
1521 CAAATTAAAGGAAATAAATTCAGTTTTATGTTAGCCTTCCTTGGTGCATCAGGGTGTCAGTGGAAATAGGATCAGGTGGT
1601 GTGTGTGTGTGTGTTTTGTGTGTGTGTGTACACATGTGTTTATATATACATGTGTGAGGGAAAGTGTGTACATATATGTA
1681 GGATTGTAACCAGACGGAAAAGAACGAGGATCTCCAGGGTGTTTGAATCAGCAACAGATTTGTGTTTTCTAACATGCATT
1761 TAGTTGGAGAGGCATGGTTCTGTTTGTTTTGTTTTGATCTAATTTGCCATTGGAAATAGGTACAGTTACACAGAGAAGGA
1841 AGAACCAGGAAAGTGAGATCCATGAAACTAAATGAGCAGCTGTCAGAATCCAGTGTGGCTGAGCCTACCTAGCTTATGAA
1921 ATCTAACCCAGGGTTCCCTGAGTCCAAGACCACTTAGATTATTAAGATTTTGAACGTCCAGAGGAGTGAAAAGTCTGTTT
2001 TCTGACGTAAGCCGGAGCTGAGGATAAAGCCAGAGGCCAGTGGATTAGGTGTATGGAATGTGGATGGAGAGGGCTTGTGT
2081 GGGATGTGGCCAGGGAGTGGGTGAGGAAGGCCGCTTCTAAATGGCCTGTAAAAACTTGAGATTGGATAGACGAAAGGAAA
2161 TGGAGAAATTAAAGAATTGGAGAAACTAGTTATCTGTGTTGCTGACTTTGGGACCCATCCAAGACTCCTGCCCTTGGGGT
2241 GTTCCATGGTGGTTTCTTCCTGCCTGGGCGCCACCCTTTCCCCAGTTCAGGCCCTCCCTGGAGGACTAGTTTGTGTATTG
2321 GTATCCTCCCCAGTGGACCCAAACCAGCGCATACTTGGTGTGTGGAGATGGGAGACAAAGGACAGATCTAGGAGCCTTGA
2401 AGGATCACCAGCCACCGACCCTCCATCAGGGCCAACTGGGCAGGAAAGGGAACATTGCAGACCTGATTTCCCGACGATGT
2481 CACCCTGTCCTCCCTCCTTGCTTCTTGCTCTGCTAACTCAACTCTGCCTTCCTCTTTTTCATTCTTCTACTCTGCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuUAAUCCAUCACCGUCACCUu 5'
            || |||  ||| ||||||| 
Target 5' gcATCAGG--GTGTCAGTGGAa 3'
1566 - 1585 164.00 -17.10
2
miRNA  3' uuUAAUC---CAUCACCGUCACCUu 5'
            |||:|   || ||  ||||||| 
Target 5' gaATTGGAATGT-GTCACAGTGGAt 3'
580 - 603 155.00 -15.50
3
miRNA  3' uuuaaUCCAUCACC-GUCACCUu 5'
               ||  || || ||||||| 
Target 5' gataaAGCCAGAGGCCAGTGGAt 3'
2023 - 2045 153.00 -13.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31960344 47 COSMIC
COSN28880430 65 COSMIC
COSN31579997 248 COSMIC
COSN31480156 254 COSMIC
COSN8646308 306 COSMIC
COSN31485708 329 COSMIC
COSN26601271 343 COSMIC
COSN30541266 343 COSMIC
COSN30164680 402 COSMIC
COSN20332038 457 COSMIC
COSN29463153 457 COSMIC
COSN31488299 490 COSMIC
COSN26563450 514 COSMIC
COSN1409627 577 COSMIC
COSN31514092 631 COSMIC
COSN23177621 807 COSMIC
COSN1091132 981 COSMIC
COSN20095498 981 COSMIC
COSN20095496 984 COSMIC
COSN20095494 985 COSMIC
COSN6522352 1126 COSMIC
COSN6507997 1240 COSMIC
COSN21260910 1430 COSMIC
COSN22264799 1855 COSMIC
COSN32063189 1891 COSMIC
COSN6005526 1891 COSMIC
COSN20095502 2005 COSMIC
COSN20095506 2006 COSMIC
COSN20136803 2321 COSMIC
COSN24896250 2461 COSMIC
COSN5732930 2871 COSMIC
COSN26151719 2873 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1236468027 4 dbSNP
rs917425372 6 dbSNP
rs971583371 7 dbSNP
rs780950872 12 dbSNP
rs747958546 22 dbSNP
rs769423337 26 dbSNP
rs1318258542 27 dbSNP
rs1207388937 28 dbSNP
rs777305853 29 dbSNP
rs1462178965 30 dbSNP
rs1206070155 32 dbSNP
rs1236750253 37 dbSNP
rs1371094233 38 dbSNP
rs188568949 41 dbSNP
rs1178065765 44 dbSNP
rs1410426440 45 dbSNP
rs1431549258 46 dbSNP
rs1175488377 47 dbSNP
rs1430011259 48 dbSNP
rs980780937 61 dbSNP
rs1193128509 72 dbSNP
rs567139366 81 dbSNP
rs984747264 87 dbSNP
rs1365270818 96 dbSNP
rs868208239 101 dbSNP
rs1159094414 103 dbSNP
rs1214677678 113 dbSNP
rs936029204 114 dbSNP
rs1475749483 115 dbSNP
rs1210826197 117 dbSNP
rs1195443482 120 dbSNP
rs1451634468 128 dbSNP
rs1054526863 140 dbSNP
rs1202939459 142 dbSNP
rs1486675712 143 dbSNP
rs1411493446 154 dbSNP
rs910139616 163 dbSNP
rs1425384757 166 dbSNP
rs913340863 173 dbSNP
rs1347763377 180 dbSNP
rs946121277 186 dbSNP
rs1417485650 187 dbSNP
rs1040191066 190 dbSNP
rs1380736264 199 dbSNP
rs964560116 199 dbSNP
rs754509653 202 dbSNP
rs996064042 204 dbSNP
rs1360669701 206 dbSNP
rs1433811892 214 dbSNP
rs1373426708 225 dbSNP
rs1446641519 230 dbSNP
rs1175362694 231 dbSNP
rs543768555 232 dbSNP
rs1371986325 242 dbSNP
rs922663148 246 dbSNP
rs1284171921 249 dbSNP
rs1190481928 268 dbSNP
rs1377597807 274 dbSNP
rs752055367 275 dbSNP
rs371454233 276 dbSNP
rs1209740798 284 dbSNP
rs1278643173 286 dbSNP
rs755530840 288 dbSNP
rs1346406934 292 dbSNP
rs1316213216 295 dbSNP
rs374755150 304 dbSNP
rs1225393441 305 dbSNP
rs1238265903 319 dbSNP
rs1014671247 320 dbSNP
rs1414398917 322 dbSNP
rs1288413109 329 dbSNP
rs539064200 330 dbSNP
rs182109840 337 dbSNP
rs1013291981 340 dbSNP
rs529366627 352 dbSNP
rs1484212100 355 dbSNP
rs1463028553 357 dbSNP
rs904478232 358 dbSNP
rs980368176 362 dbSNP
rs1474031019 363 dbSNP
rs1035038294 366 dbSNP
rs1190137164 367 dbSNP
rs528929031 369 dbSNP
rs186705413 370 dbSNP
rs371547344 372 dbSNP
rs1320006041 381 dbSNP
rs990522043 382 dbSNP
rs1001767300 391 dbSNP
rs369312021 395 dbSNP
rs976177440 396 dbSNP
rs895670888 400 dbSNP
rs923085190 402 dbSNP
rs41378649 405 dbSNP
rs149779912 411 dbSNP
rs753070456 416 dbSNP
rs1448912941 417 dbSNP
rs1005259191 429 dbSNP
rs778348810 439 dbSNP
rs1163658960 450 dbSNP
rs1455059249 451 dbSNP
rs887723777 459 dbSNP
rs1337901169 471 dbSNP
rs1376704382 479 dbSNP
rs563893114 483 dbSNP
rs1238425696 485 dbSNP
rs941968177 497 dbSNP
rs1036399979 498 dbSNP
rs1342849883 499 dbSNP
rs1473305444 507 dbSNP
rs897516867 511 dbSNP
rs1232666374 512 dbSNP
rs1017598706 519 dbSNP
rs1459522876 520 dbSNP
rs1238858857 525 dbSNP
rs1013261122 530 dbSNP
rs1467293119 531 dbSNP
rs1292233658 535 dbSNP
rs756482306 545 dbSNP
rs1349602683 546 dbSNP
rs1277571427 552 dbSNP
rs1242214734 555 dbSNP
rs192330867 567 dbSNP
rs1438148468 568 dbSNP
rs539077966 578 dbSNP
rs549709800 587 dbSNP
rs1323730185 592 dbSNP
rs1029760504 593 dbSNP
rs184716547 601 dbSNP
rs778521601 608 dbSNP
rs1442055316 630 dbSNP
rs1381527212 640 dbSNP
rs988150542 644 dbSNP
rs1002150060 645 dbSNP
rs1248533428 648 dbSNP
rs1276592090 652 dbSNP
rs1034531357 658 dbSNP
rs1446701025 665 dbSNP
rs747781071 671 dbSNP
rs1281884279 679 dbSNP
rs1218576375 682 dbSNP
rs957816278 698 dbSNP
rs1204287855 703 dbSNP
rs990434052 707 dbSNP
rs1231992620 712 dbSNP
rs1020267351 714 dbSNP
rs913989584 716 dbSNP
rs1429584334 717 dbSNP
rs1343111372 720 dbSNP
rs1296713763 722 dbSNP
rs1421854254 727 dbSNP
rs976146267 739 dbSNP
rs771859230 744 dbSNP
rs1431961634 746 dbSNP
rs1427340699 747 dbSNP
rs781656879 754 dbSNP
rs1180256153 774 dbSNP
rs1233200118 782 dbSNP
rs931824317 786 dbSNP
rs1196151594 789 dbSNP
rs1488454029 794 dbSNP
rs979490618 800 dbSNP
rs1208620495 802 dbSNP
rs986337760 804 dbSNP
rs1278675828 807 dbSNP
rs145703577 820 dbSNP
rs1359281293 824 dbSNP
rs1279655245 826 dbSNP
rs1400234505 836 dbSNP
rs1469857487 841 dbSNP
rs1341458836 843 dbSNP
rs1312717445 845 dbSNP
rs1464982755 848 dbSNP
rs1361452438 853 dbSNP
rs937251065 856 dbSNP
rs1409407551 858 dbSNP
rs1421575268 860 dbSNP
rs1400171660 865 dbSNP
rs941920046 867 dbSNP
rs1445148109 875 dbSNP
rs1036251940 877 dbSNP
rs1056132330 907 dbSNP
rs895618567 911 dbSNP
rs1256532196 912 dbSNP
rs1331328847 923 dbSNP
rs1179937939 927 dbSNP
rs949869218 929 dbSNP
rs1046847010 932 dbSNP
rs1203770286 946 dbSNP
rs1378457698 954 dbSNP
rs886893911 955 dbSNP
rs1273284164 968 dbSNP
rs1458021221 971 dbSNP
rs1491193026 971 dbSNP
rs760174914 971 dbSNP
rs770866967 971 dbSNP
rs1176494372 972 dbSNP
rs1198772929 972 dbSNP
rs184137612 972 dbSNP
rs199619064 972 dbSNP
rs200568394 972 dbSNP
rs373771260 972 dbSNP
rs374163597 972 dbSNP
rs535741655 972 dbSNP
rs60542780 972 dbSNP
rs760051819 972 dbSNP
rs796319627 972 dbSNP
rs1347535427 974 dbSNP
rs879147574 974 dbSNP
rs904985431 974 dbSNP
rs1246579092 975 dbSNP
rs1001962877 976 dbSNP
rs1237526313 979 dbSNP
rs751439297 979 dbSNP
rs1005619832 980 dbSNP
rs1224162017 980 dbSNP
rs3065060 980 dbSNP
rs201651057 981 dbSNP
rs893316306 981 dbSNP
rs1350239522 982 dbSNP
rs1158192528 983 dbSNP
rs1437716750 983 dbSNP
rs1012227799 984 dbSNP
rs1316018285 985 dbSNP
rs375195531 986 dbSNP
rs997078503 989 dbSNP
rs1200416801 990 dbSNP
rs967368061 990 dbSNP
rs1273454242 992 dbSNP
rs188517132 993 dbSNP
rs1029875335 996 dbSNP
rs1196379473 998 dbSNP
rs1312015159 1001 dbSNP
rs1241545552 1007 dbSNP
rs1370274342 1008 dbSNP
rs955498672 1010 dbSNP
rs988307568 1024 dbSNP
rs1391808219 1030 dbSNP
rs771508286 1056 dbSNP
rs189511395 1067 dbSNP
rs1480501976 1073 dbSNP
rs1362220106 1077 dbSNP
rs1428314999 1082 dbSNP
rs1159134038 1088 dbSNP
rs1030342664 1089 dbSNP
rs1375402207 1100 dbSNP
rs1200459781 1101 dbSNP
rs953550016 1107 dbSNP
rs968188673 1110 dbSNP
rs1191071366 1119 dbSNP
rs164146 1121 dbSNP
rs535196802 1126 dbSNP
rs164147 1141 dbSNP
rs578169198 1152 dbSNP
rs991365919 1156 dbSNP
rs1254327095 1158 dbSNP
rs1397728218 1162 dbSNP
rs193099087 1168 dbSNP
rs563627680 1170 dbSNP
rs768671072 1171 dbSNP
rs1405729635 1172 dbSNP
rs1046963043 1176 dbSNP
rs1277686365 1180 dbSNP
rs6690805 1182 dbSNP
rs185305674 1186 dbSNP
rs1229541039 1197 dbSNP
rs937727580 1211 dbSNP
rs1355463912 1214 dbSNP
rs776475731 1215 dbSNP
rs1188509682 1219 dbSNP
rs1291642704 1226 dbSNP
rs164148 1229 dbSNP
rs559868533 1230 dbSNP
rs1194930449 1232 dbSNP
rs1038539603 1238 dbSNP
rs1876986 1240 dbSNP
rs1260424332 1244 dbSNP
rs1459097440 1248 dbSNP
rs749390103 1250 dbSNP
rs996917707 1254 dbSNP
rs773500131 1256 dbSNP
rs1278596279 1260 dbSNP
rs189761133 1260 dbSNP
rs564233031 1262 dbSNP
rs1009678240 1265 dbSNP
rs1021055522 1272 dbSNP
rs997772027 1275 dbSNP
rs968635230 1293 dbSNP
rs1000924097 1295 dbSNP
rs1398894295 1299 dbSNP
rs533207851 1303 dbSNP
rs1367809945 1317 dbSNP
rs1466859083 1320 dbSNP
rs149008943 1322 dbSNP
rs164149 1325 dbSNP
rs1472634654 1326 dbSNP
rs774600131 1329 dbSNP
rs181358895 1330 dbSNP
rs1237639938 1335 dbSNP
rs1016373771 1343 dbSNP
rs963542711 1347 dbSNP
rs759570053 1348 dbSNP
rs374473829 1352 dbSNP
rs565762310 1352 dbSNP
rs548695721 1354 dbSNP
rs768043725 1357 dbSNP
rs1316897616 1360 dbSNP
rs1359812980 1363 dbSNP
rs164150 1374 dbSNP
rs941197350 1376 dbSNP
rs1283430505 1391 dbSNP
rs926267308 1394 dbSNP
rs144454744 1396 dbSNP
rs1322417567 1398 dbSNP
rs1053942573 1399 dbSNP
rs146612619 1400 dbSNP
rs188329200 1425 dbSNP
rs932311099 1431 dbSNP
rs1380166429 1434 dbSNP
rs181780398 1443 dbSNP
rs1050747071 1451 dbSNP
rs1177322986 1453 dbSNP
rs1185970019 1460 dbSNP
rs891360269 1462 dbSNP
rs1009745499 1470 dbSNP
rs1042626131 1475 dbSNP
rs1450127847 1477 dbSNP
rs1291755844 1490 dbSNP
rs1277458984 1491 dbSNP
rs903372941 1494 dbSNP
rs903980465 1498 dbSNP
rs1445610920 1507 dbSNP
rs1158342681 1512 dbSNP
rs1001479398 1522 dbSNP
rs1455457364 1530 dbSNP
rs557677141 1538 dbSNP
rs997742288 1539 dbSNP
rs1323828506 1540 dbSNP
rs1052053731 1550 dbSNP
rs574484550 1551 dbSNP
rs1157332363 1555 dbSNP
rs959748258 1559 dbSNP
rs1013571999 1568 dbSNP
rs1024959005 1573 dbSNP
rs1326824105 1580 dbSNP
rs1016753875 1582 dbSNP
rs1477155113 1588 dbSNP
rs764449871 1596 dbSNP
rs737641 1597 dbSNP
rs369596203 1599 dbSNP
rs749696627 1599 dbSNP
rs767235842 1599 dbSNP
rs543017005 1601 dbSNP
rs1354370260 1604 dbSNP
rs1277284359 1606 dbSNP
rs146004120 1609 dbSNP
rs982663586 1610 dbSNP
rs71093165 1615 dbSNP
rs12754822 1616 dbSNP
rs1346516881 1617 dbSNP
rs1399037929 1617 dbSNP
rs970562133 1617 dbSNP
rs12727261 1619 dbSNP
rs962573323 1623 dbSNP
rs1402394621 1629 dbSNP
rs1202396041 1634 dbSNP
rs1245507938 1635 dbSNP
rs974348281 1636 dbSNP
rs981974864 1637 dbSNP
rs544870282 1641 dbSNP
rs959288395 1641 dbSNP
rs1427390347 1642 dbSNP
rs1177352788 1643 dbSNP
rs1462076746 1643 dbSNP
rs989123380 1644 dbSNP
rs540872330 1645 dbSNP
rs1195656025 1651 dbSNP
rs368656853 1653 dbSNP
rs932427139 1657 dbSNP
rs1050814089 1658 dbSNP
rs912195848 1659 dbSNP
rs1421111703 1666 dbSNP
rs1313392197 1667 dbSNP
rs758072730 1671 dbSNP
rs564355186 1673 dbSNP
rs183572528 1677 dbSNP
rs1220020885 1683 dbSNP
rs1276685427 1690 dbSNP
rs945085524 1696 dbSNP
rs1377194286 1697 dbSNP
rs164151 1706 dbSNP
rs1302735878 1711 dbSNP
rs1178545043 1720 dbSNP
rs141331667 1722 dbSNP
rs1360941623 1742 dbSNP
rs528878252 1747 dbSNP
rs933501320 1753 dbSNP
rs548533896 1754 dbSNP
rs1329082891 1759 dbSNP
rs1173105371 1764 dbSNP
rs889409450 1766 dbSNP
rs186845695 1767 dbSNP
rs1412833148 1769 dbSNP
rs1055722816 1770 dbSNP
rs895332142 1775 dbSNP
rs1013650375 1776 dbSNP
rs1037669207 1777 dbSNP
rs1197524462 1783 dbSNP
rs1456078924 1799 dbSNP
rs145100542 1808 dbSNP
rs993529229 1810 dbSNP
rs760436866 1811 dbSNP
rs1308397558 1812 dbSNP
rs1328923881 1814 dbSNP
rs1312519998 1824 dbSNP
rs1227070828 1826 dbSNP
rs1382043983 1841 dbSNP
rs1315801184 1843 dbSNP
rs1446049916 1845 dbSNP
rs164152 1847 dbSNP
rs1265594333 1852 dbSNP
rs1462734547 1858 dbSNP
rs1003410306 1861 dbSNP
rs1324911604 1869 dbSNP
rs1198527682 1873 dbSNP
rs753805077 1880 dbSNP
rs1425472652 1882 dbSNP
rs1249986946 1889 dbSNP
rs754497691 1892 dbSNP
rs571850047 1909 dbSNP
rs537231647 1914 dbSNP
rs557713929 1917 dbSNP
rs973914729 1922 dbSNP
rs1177400934 1931 dbSNP
rs1479523413 1933 dbSNP
rs1028551467 1935 dbSNP
rs1219895833 1950 dbSNP
rs1362050025 1953 dbSNP
rs1430024517 1957 dbSNP
rs966396350 1963 dbSNP
rs1374737777 1966 dbSNP
rs567926605 1967 dbSNP
rs781177930 1974 dbSNP
rs953887617 1977 dbSNP
rs191283711 1981 dbSNP
rs11383407 2004 dbSNP
rs183076988 2004 dbSNP
rs1491177940 2005 dbSNP
rs61332953 2005 dbSNP
rs67341046 2005 dbSNP
rs187813027 2006 dbSNP
rs553356675 2007 dbSNP
rs912350236 2008 dbSNP
rs945035242 2014 dbSNP
rs978188569 2015 dbSNP
rs1181984381 2024 dbSNP
rs1432219351 2033 dbSNP
rs1264751789 2037 dbSNP
rs925537906 2044 dbSNP
rs943603623 2045 dbSNP
rs1270118121 2047 dbSNP
rs1379491202 2049 dbSNP
rs1216487094 2054 dbSNP
rs1283405011 2057 dbSNP
rs1352240086 2059 dbSNP
rs1262554042 2064 dbSNP
rs936893764 2067 dbSNP
rs1339202235 2078 dbSNP
rs573153233 2080 dbSNP
rs1038387478 2082 dbSNP
rs1055395692 2085 dbSNP
rs899152714 2092 dbSNP
rs895284676 2094 dbSNP
rs949536712 2095 dbSNP
rs1297396430 2096 dbSNP
rs1398059829 2097 dbSNP
rs1362439391 2102 dbSNP
rs1159085730 2106 dbSNP
rs1046516108 2110 dbSNP
rs1375453652 2111 dbSNP
rs1294054230 2113 dbSNP
rs545528004 2114 dbSNP
rs1205632439 2117 dbSNP
rs1487521393 2121 dbSNP
rs754889905 2125 dbSNP
rs1004872757 2130 dbSNP
rs1016701840 2137 dbSNP
rs1224915939 2149 dbSNP
rs558770181 2152 dbSNP
rs1477530342 2153 dbSNP
rs899182641 2158 dbSNP
rs1225547870 2162 dbSNP
rs995795382 2175 dbSNP
rs1324619125 2178 dbSNP
rs182552951 2182 dbSNP
rs1421537728 2183 dbSNP
rs1216504523 2187 dbSNP
rs1028243463 2190 dbSNP
rs1004037526 2192 dbSNP
rs1395436395 2195 dbSNP
rs1054941856 2197 dbSNP
rs186469726 2206 dbSNP
rs72702015 2207 dbSNP
rs1469983812 2210 dbSNP
rs986629448 2211 dbSNP
rs148227262 2215 dbSNP
rs1383112554 2217 dbSNP
rs1019307927 2219 dbSNP
rs561029074 2228 dbSNP
rs1194486694 2231 dbSNP
rs542216512 2235 dbSNP
rs1254160197 2239 dbSNP
rs1359415658 2240 dbSNP
rs559347481 2241 dbSNP
rs936361585 2242 dbSNP
rs1397553254 2243 dbSNP
rs1270596650 2253 dbSNP
rs1396409939 2263 dbSNP
rs1029340566 2267 dbSNP
rs1364720550 2268 dbSNP
rs533096748 2270 dbSNP
rs916876489 2271 dbSNP
rs868323082 2277 dbSNP
rs1398961787 2301 dbSNP
rs1312461250 2302 dbSNP
rs949525435 2308 dbSNP
rs1466905078 2316 dbSNP
rs164588 2323 dbSNP
rs1248520832 2326 dbSNP
rs907942335 2331 dbSNP
rs1488028962 2337 dbSNP
rs1213705057 2345 dbSNP
rs940748045 2346 dbSNP
rs1445270412 2349 dbSNP
rs564805444 2350 dbSNP
rs1486172800 2351 dbSNP
rs899122599 2355 dbSNP
rs140194988 2363 dbSNP
rs1208959093 2369 dbSNP
rs920879075 2369 dbSNP
rs929566551 2374 dbSNP
rs1181145281 2377 dbSNP
rs1241103233 2384 dbSNP
rs1446220768 2386 dbSNP
rs1049624077 2387 dbSNP
rs551156305 2391 dbSNP
rs1163871653 2393 dbSNP
rs1293807626 2396 dbSNP
rs1246653845 2403 dbSNP
rs1375490193 2415 dbSNP
rs150308065 2417 dbSNP
rs939421026 2418 dbSNP
rs1055649412 2420 dbSNP
rs1322485364 2422 dbSNP
rs894962044 2432 dbSNP
rs1011198428 2437 dbSNP
rs889728368 2440 dbSNP
rs1007995363 2448 dbSNP
rs1425895977 2449 dbSNP
rs1019381238 2450 dbSNP
rs1156994765 2457 dbSNP
rs1345194128 2470 dbSNP
rs1233601059 2471 dbSNP
rs137864645 2473 dbSNP
rs999651097 2474 dbSNP
rs547306922 2476 dbSNP
rs1352983003 2477 dbSNP
rs999447451 2489 dbSNP
rs1325328202 2490 dbSNP
rs1224906481 2497 dbSNP
rs1504424 2498 dbSNP
rs1273836083 2508 dbSNP
rs566922342 2509 dbSNP
rs1433874985 2518 dbSNP
rs1343995635 2519 dbSNP
rs143733517 2527 dbSNP
rs1454892117 2528 dbSNP
rs559033602 2538 dbSNP
rs1305413999 2540 dbSNP
rs955243660 2550 dbSNP
rs990535600 2552 dbSNP
rs868245343 2556 dbSNP
rs1222238400 2580 dbSNP
rs1286439006 2583 dbSNP
rs1317535252 2584 dbSNP
rs1156986840 2586 dbSNP
rs1018479653 2588 dbSNP
rs1479600857 2589 dbSNP
rs916822600 2594 dbSNP
rs575612926 2601 dbSNP
rs1431149437 2608 dbSNP
rs147212288 2612 dbSNP
rs55996500 2623 dbSNP
rs1487847181 2630 dbSNP
rs1260850783 2632 dbSNP
rs973506657 2638 dbSNP
rs982380280 2639 dbSNP
rs138846197 2640 dbSNP
rs1217115181 2646 dbSNP
rs1183995547 2653 dbSNP
rs940871834 2654 dbSNP
rs1224434633 2660 dbSNP
rs1340330790 2666 dbSNP
rs868387686 2673 dbSNP
rs573494463 2677 dbSNP
rs983679748 2681 dbSNP
rs927957007 2682 dbSNP
rs1333668000 2683 dbSNP
rs1468418163 2684 dbSNP
rs746699761 2685 dbSNP
rs1408497965 2689 dbSNP
rs920723786 2693 dbSNP
rs1177419401 2695 dbSNP
rs1477347936 2697 dbSNP
rs939373303 2705 dbSNP
rs75833440 2706 dbSNP
rs931961970 2711 dbSNP
rs370112964 2712 dbSNP
rs559371730 2714 dbSNP
rs116187777 2720 dbSNP
rs1207349531 2725 dbSNP
rs1462274379 2732 dbSNP
rs1413409613 2742 dbSNP
rs764396815 2748 dbSNP
rs1043540132 2755 dbSNP
rs1404514582 2759 dbSNP
rs1040945990 2766 dbSNP
rs1471214924 2768 dbSNP
rs1450456085 2769 dbSNP
rs902307669 2771 dbSNP
rs754233024 2781 dbSNP
rs1465343204 2784 dbSNP
rs1032500933 2789 dbSNP
rs1172346704 2791 dbSNP
rs142827402 2799 dbSNP
rs867237940 2806 dbSNP
rs565001581 2807 dbSNP
rs935207331 2809 dbSNP
rs1445871155 2811 dbSNP
rs751229388 2819 dbSNP
rs1051031102 2821 dbSNP
rs1218697320 2822 dbSNP
rs754442125 2830 dbSNP
rs1479491612 2849 dbSNP
rs1023283651 2853 dbSNP
rs530574943 2854 dbSNP
rs1308450841 2855 dbSNP
rs890793792 2860 dbSNP
rs191266022 2863 dbSNP
rs982326945 2865 dbSNP
rs908163677 2866 dbSNP
rs780578310 2867 dbSNP
rs1446312391 2869 dbSNP
rs1371389186 2886 dbSNP
rs1300122714 2887 dbSNP
rs973624884 2899 dbSNP
rs1349113708 2900 dbSNP
rs1161574479 2909 dbSNP
rs1426518863 2917 dbSNP
rs1435850189 2921 dbSNP
rs1385310910 2927 dbSNP
rs898197655 2932 dbSNP
rs1416804219 2939 dbSNP
rs1206265546 2942 dbSNP
rs1252143078 2943 dbSNP
rs1439807015 2945 dbSNP
rs1233070817 2953 dbSNP
rs1177458341 2954 dbSNP
rs1481134188 2958 dbSNP
rs1268681161 2959 dbSNP
rs920656542 2963 dbSNP
rs867459769 2971 dbSNP
rs932059836 2976 dbSNP
rs1220861088 2977 dbSNP
rs1362294268 2983 dbSNP
rs188043785 2985 dbSNP
rs1293160066 2996 dbSNP
rs552989426 3003 dbSNP
rs986189496 3009 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000361897.5 | 3UTR | AGUGGAAAUAGGAUCAGGUGGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000361897.5 | 3UTR | AGUGGAAAUAGGAUCAGGUGGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000361897.5 | 3UTR | CAGUGGAAAUAGGAUCAGGUGGUGUGUGUGUGUGUGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055374 PDCD4 programmed cell death 4 2 4
MIRT378341 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT444668 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446953 CD248 CD248 molecule 2 2
MIRT460332 CAMK4 calcium/calmodulin dependent protein kinase IV 2 6
MIRT464078 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464586 UBN2 ubinuclein 2 2 2
MIRT468482 SESN3 sestrin 3 2 2
MIRT468962 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT475455 HSPA8 heat shock protein family A (Hsp70) member 8 2 2
MIRT482403 ADRB1 adrenoceptor beta 1 2 10
MIRT486992 ZFAND2B zinc finger AN1-type containing 2B 2 2
MIRT489397 TUBB2A tubulin beta 2A class IIa 2 2
MIRT526319 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526560 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526732 ZNF138 zinc finger protein 138 2 8
MIRT531581 STXBP5L syntaxin binding protein 5 like 2 2
MIRT532011 NOX5 NADPH oxidase 5 2 2
MIRT533407 TXLNG taxilin gamma 2 2
MIRT533436 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533866 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT539254 ANKRD50 ankyrin repeat domain 50 2 2
MIRT541451 C15orf48 chromosome 15 open reading frame 48 2 2
MIRT566794 MIER3 MIER family member 3 2 2
MIRT569294 SURF6 surfeit 6 2 2
MIRT571336 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT572802 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT572813 MYO1C myosin IC 2 2
MIRT574219 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT607259 GRAMD1B GRAM domain containing 1B 2 4
MIRT609307 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT615459 REPS1 RALBP1 associated Eps domain containing 1 2 2
MIRT616861 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT619415 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT619652 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT625325 TNFRSF13B TNF receptor superfamily member 13B 2 2
MIRT638980 ARFIP2 ADP ribosylation factor interacting protein 2 2 2
MIRT639458 ZNF429 zinc finger protein 429 2 2
MIRT640550 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT641473 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642720 ATXN3 ataxin 3 2 2
MIRT643048 SMN1 survival of motor neuron 1, telomeric 2 2
MIRT644921 SMN2 survival of motor neuron 2, centromeric 2 2
MIRT645875 ZNF275 zinc finger protein 275 2 2
MIRT649824 LIPG lipase G, endothelial type 2 2
MIRT649851 GYS2 glycogen synthase 2 2 2
MIRT649972 TRAFD1 TRAF-type zinc finger domain containing 1 2 2
MIRT650675 ZNF259 ZPR1 zinc finger 1 1
MIRT651319 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT652876 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT652881 SYVN1 synoviolin 1 2 2
MIRT654144 RPAP2 RNA polymerase II associated protein 2 2 2
MIRT657080 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657181 INO80C INO80 complex subunit C 2 2
MIRT657830 GJD3 gap junction protein delta 3 2 2
MIRT657897 GDF7 growth differentiation factor 7 2 2
MIRT659631 CDKN2AIP CDKN2A interacting protein 2 2
MIRT663115 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT664739 METTL16 methyltransferase like 16 2 2
MIRT667551 LRAT lecithin retinol acyltransferase 2 2
MIRT668552 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT682893 XIAP X-linked inhibitor of apoptosis 2 2
MIRT683092 PRRG4 proline rich and Gla domain 4 2 2
MIRT683102 TIMM10B translocase of inner mitochondrial membrane 10B 2 2
MIRT697648 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT709158 ZNF419 zinc finger protein 419 2 2
MIRT713220 RCAN2 regulator of calcineurin 2 2 2
MIRT713277 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT715008 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT715051 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT715696 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT717250 TMEM246 transmembrane protein 246 2 2
MIRT717322 PGK1 phosphoglycerate kinase 1 2 2
MIRT717587 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT718122 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718418 CALN1 calneuron 1 2 2
MIRT718750 ZNF490 zinc finger protein 490 2 2
MIRT720048 PPP1R3F protein phosphatase 1 regulatory subunit 3F 2 2
MIRT721497 THRB thyroid hormone receptor beta 2 2
MIRT722531 EPRS glutamyl-prolyl-tRNA synthetase 2 2
MIRT723279 KRTAP21-2 keratin associated protein 21-2 2 2
MIRT724813 MSX2 msh homeobox 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6509-3p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6509-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6509-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6509-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6509-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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