pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SNRPD1   
Synonyms HsT2456, SMD1, SNRPD, Sm-D1
Description small nuclear ribonucleoprotein D1 polypeptide
Transcript NM_006938   
Expression
Putative miRNA Targets on SNRPD1
3'UTR of SNRPD1
(miRNA target sites are highlighted)
>SNRPD1|NM_006938|3'UTR
   1 TGTCTCTCAAGATTTCAAAGTCATATGAGATTTGGGATATTTTTTGTACAGGTTGTGTTTGTTTATGTCAGTTTTTAATA
  81 AACATAAATGTGGGACAGAGCTGTCTATTTAGTATATCAAAGTTTTAGTAGTTTCCTCCACATTCACGAAATTACCACAG
 161 TGAGAGCTAAGCATTTCTACTGGGCAGTTTCATTTTTAGTTGATCAGGTTTTAAGTTTTTGAACTAAAATTTTTCTTTTT
 241 CTTTTTATGATGAATAAGGTTAAAATAAAAGCCTTAGACAAATTAAATTTGGCAGAGTTTAATTGAGCAAAGGACAATTC
 321 ACAAATCAGGTAGCCCCTGAACCATAATAGGCTCAGAGGCTTCAGCCCAGCTGCATAGTTGAAGATTTATGGACAGAAGG
 401 AAAGTGATGTATGGAAAATGGAAGTGAGATACAGCAACAGCCGGATTAGTTACAGTTCAGCGTTTGCCTTATTTGAATAT
 481 GGTTTGAACAGTTCGCTGTCTTTGGTTGGCTGAAACTTAGTGATTGCCACAAGAGTAGGGTACCGTCTGTTTACACGTCC
 561 AGTTAGGCTACAGTTCTATGTACTGAGAAACCTTTAAGCTGAACTTGAGATATGTAAAGAGACTTTAGGCTAAACTTAAC
 641 AATATATATAGGATATATACCCTTCTACTTCACATGCACTGAATATGCATTTTATTGCTTTACTCTTCATTCTGTGGCAC
 721 CTACCCACAGGGGAAGTAAGAAGTTTGTTTTGGTATTTCGGAAACTAAAGTCCTTATGGGATGGGGTCTAGAATTGATTC
 801 TCCTTTCCTGAGTTTTACTCCACGGAGTCTTAGGTACCTGGTAAAAAGTTGTCTTCTAAATTAAGGGTCATTGCTTTGTT
 881 GTCTAGCTGCTAATGTCTTACTTTTGTTTCTTTTGCTTTTTAATCAGTTCTTAATAGGATATAGTTTTATGTTTTCCAAG
 961 TTATAACTTGGAGTTAATGGTCACTAGATTATCAGTTATGAGCAGTGTTAAAATCTCCTATTAATGTGTAATGTACCTGT
1041 CAGTGCCTCCTTTATTAAGGGGTTCTTTGAGAATAAAAGAGAAAAGACCTACTTTATTTGACAGCAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acggaGGAGGUCCUAGGUGUGu 5'
               ::|||    ||||||: 
Target 5' agtagTTTCC----TCCACATt 3'
127 - 144 127.00 -13.40
2
miRNA  3' acGGAGGAGGUCCUAGGUGUGu 5'
            |||:|| |    |:||||: 
Target 5' acCCTTCTAC----TTCACATg 3'
659 - 676 122.00 -12.70
3
miRNA  3' acggaGGAGGUCCUAGGUGUGu 5'
               || :| |  |::|||| 
Target 5' gggtaCCGTCTG--TTTACACg 3'
538 - 557 113.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30447165 3 COSMIC
COSN30459881 5 COSMIC
COSN31574243 12 COSMIC
COSN1203901 40 COSMIC
COSN26996217 46 COSMIC
COSN30516102 52 COSMIC
COSN26603815 62 COSMIC
COSN31560554 69 COSMIC
COSN31572420 97 COSMIC
COSN31575935 100 COSMIC
COSN31575770 144 COSMIC
COSN30167830 149 COSMIC
COSN17938070 402 COSMIC
COSN27774134 547 COSMIC
COSN19395922 1066 COSMIC
COSN27234389 1297 COSMIC
COSN29011782 1297 COSMIC
COSN9327408 2168 COSMIC
COSN16230356 2302 COSMIC
COSN20591101 2487 COSMIC
COSN24039119 3059 COSMIC
COSN8395420 3098 COSMIC
COSN24776306 3319 COSMIC
COSN19437145 3520 COSMIC
COSN28911458 3722 COSMIC
COSN7460787 3817 COSMIC
COSN17786401 4004 COSMIC
COSN29750381 4110 COSMIC
COSN17554753 4189 COSMIC
COSN22324059 4253 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1222165490 3 dbSNP
rs778618607 3 dbSNP
rs373016009 4 dbSNP
rs200019340 9 dbSNP
rs764043290 11 dbSNP
rs751129695 19 dbSNP
rs113067364 22 dbSNP
rs750227734 23 dbSNP
rs1195154865 24 dbSNP
rs756761537 25 dbSNP
rs767335454 27 dbSNP
rs1332656489 28 dbSNP
rs758189599 31 dbSNP
rs191738518 41 dbSNP
rs756541252 42 dbSNP
rs1301094524 46 dbSNP
rs570427437 47 dbSNP
rs780312482 50 dbSNP
rs376057482 52 dbSNP
rs1365819936 56 dbSNP
rs779357359 56 dbSNP
rs1379254332 57 dbSNP
rs1371980306 67 dbSNP
rs1171783522 79 dbSNP
rs1479107819 80 dbSNP
rs1427757179 82 dbSNP
rs539034884 85 dbSNP
rs1199164194 86 dbSNP
rs552961198 90 dbSNP
rs973378880 91 dbSNP
rs1291319238 97 dbSNP
rs142797517 102 dbSNP
rs937409642 106 dbSNP
rs375770836 119 dbSNP
rs1480376294 126 dbSNP
rs1251931814 127 dbSNP
rs1200559865 128 dbSNP
rs777190143 144 dbSNP
rs1319939259 148 dbSNP
rs1057471628 149 dbSNP
rs147442351 150 dbSNP
rs1042262496 165 dbSNP
rs1176016608 169 dbSNP
rs555676704 180 dbSNP
rs949269115 185 dbSNP
rs1042213061 186 dbSNP
rs903676043 187 dbSNP
rs1000667915 192 dbSNP
rs1384298022 193 dbSNP
rs1176331281 201 dbSNP
rs1481001698 202 dbSNP
rs1403232665 204 dbSNP
rs1017535690 205 dbSNP
rs1350222638 222 dbSNP
rs565844268 225 dbSNP
rs964599607 230 dbSNP
rs138203136 234 dbSNP
rs1459981392 237 dbSNP
rs1261249025 273 dbSNP
rs1329260243 274 dbSNP
rs997199465 277 dbSNP
rs113608292 283 dbSNP
rs112081085 284 dbSNP
rs112445595 286 dbSNP
rs1236557438 295 dbSNP
rs1053349756 313 dbSNP
rs1314446548 316 dbSNP
rs900199324 318 dbSNP
rs1309448609 327 dbSNP
rs995936965 332 dbSNP
rs983605013 334 dbSNP
rs1030518097 345 dbSNP
rs954888123 346 dbSNP
rs908926191 351 dbSNP
rs1313655288 354 dbSNP
rs564744277 355 dbSNP
rs963204513 360 dbSNP
rs75697984 370 dbSNP
rs1005433201 374 dbSNP
rs1015120069 398 dbSNP
rs974186803 407 dbSNP
rs1307306602 412 dbSNP
rs1157211649 425 dbSNP
rs1453418189 427 dbSNP
rs370380762 428 dbSNP
rs938251919 431 dbSNP
rs1180735222 433 dbSNP
rs116963888 436 dbSNP
rs973660259 438 dbSNP
rs1034344774 439 dbSNP
rs35689857 443 dbSNP
rs958979941 443 dbSNP
rs143424166 444 dbSNP
rs917290077 445 dbSNP
rs1258113234 448 dbSNP
rs1203168284 450 dbSNP
rs1349679778 455 dbSNP
rs1286359509 456 dbSNP
rs946157040 458 dbSNP
rs775071920 459 dbSNP
rs923790738 461 dbSNP
rs1000718542 462 dbSNP
rs762580209 463 dbSNP
rs187873362 471 dbSNP
rs1273464269 472 dbSNP
rs900451793 476 dbSNP
rs1361552214 480 dbSNP
rs1414014949 481 dbSNP
rs1053654794 495 dbSNP
rs1423013996 496 dbSNP
rs997418774 498 dbSNP
rs900164274 505 dbSNP
rs1030039048 507 dbSNP
rs931674412 508 dbSNP
rs1051448105 510 dbSNP
rs1004511444 511 dbSNP
rs1336204862 513 dbSNP
rs1446262190 516 dbSNP
rs1263591001 526 dbSNP
rs549413252 531 dbSNP
rs1357529535 539 dbSNP
rs1218467571 540 dbSNP
rs890161320 542 dbSNP
rs1004652488 543 dbSNP
rs542647496 545 dbSNP
rs376002480 546 dbSNP
rs192509712 557 dbSNP
rs550380719 558 dbSNP
rs150499609 563 dbSNP
rs1300460253 569 dbSNP
rs1223403752 571 dbSNP
rs1261773927 577 dbSNP
rs959654358 582 dbSNP
rs139522404 585 dbSNP
rs546268765 586 dbSNP
rs185647022 602 dbSNP
rs1166128381 604 dbSNP
rs1042368775 609 dbSNP
rs1424189075 610 dbSNP
rs925373823 614 dbSNP
rs1024329279 625 dbSNP
rs551504895 630 dbSNP
rs1038912368 636 dbSNP
rs1221824761 638 dbSNP
rs1452878516 641 dbSNP
rs900335855 642 dbSNP
rs933260752 650 dbSNP
rs1052117591 652 dbSNP
rs1319235576 653 dbSNP
rs977506233 657 dbSNP
rs1280578515 658 dbSNP
rs886333019 662 dbSNP
rs1275716650 665 dbSNP
rs761668060 670 dbSNP
rs1438837973 674 dbSNP
rs1352940074 676 dbSNP
rs1004965991 681 dbSNP
rs921929753 682 dbSNP
rs1466154143 688 dbSNP
rs1400944157 695 dbSNP
rs1172723213 697 dbSNP
rs923758524 700 dbSNP
rs1015915990 715 dbSNP
rs936548700 716 dbSNP
rs898942448 719 dbSNP
rs570058498 721 dbSNP
rs1478821364 724 dbSNP
rs1478001658 729 dbSNP
rs189578876 735 dbSNP
rs545288830 752 dbSNP
rs1260613974 760 dbSNP
rs1457073718 761 dbSNP
rs921809645 762 dbSNP
rs1202307327 768 dbSNP
rs555459704 774 dbSNP
rs992301386 778 dbSNP
rs1025668366 784 dbSNP
rs1371470320 786 dbSNP
rs767277295 787 dbSNP
rs575433700 791 dbSNP
rs1334919142 801 dbSNP
rs1344889979 802 dbSNP
rs1468135045 804 dbSNP
rs966959035 805 dbSNP
rs1176546463 813 dbSNP
rs978526869 818 dbSNP
rs940407500 823 dbSNP
rs925291786 824 dbSNP
rs1157663809 826 dbSNP
rs936781227 828 dbSNP
rs1036135624 830 dbSNP
rs974818703 836 dbSNP
rs1341557892 845 dbSNP
rs899326597 848 dbSNP
rs1181169982 857 dbSNP
rs995036356 859 dbSNP
rs1483221711 865 dbSNP
rs921979542 866 dbSNP
rs933157528 874 dbSNP
rs1273598047 884 dbSNP
rs373077405 887 dbSNP
rs894697449 889 dbSNP
rs1283894589 894 dbSNP
rs1241113366 897 dbSNP
rs750233287 897 dbSNP
rs1355993392 899 dbSNP
rs1313043888 903 dbSNP
rs1451938720 906 dbSNP
rs1220507330 910 dbSNP
rs748523057 911 dbSNP
rs1303357537 912 dbSNP
rs886381300 916 dbSNP
rs940598516 927 dbSNP
rs1024716241 928 dbSNP
rs1214037585 937 dbSNP
rs1161148400 951 dbSNP
rs898827716 951 dbSNP
rs1422659088 953 dbSNP
rs1264819106 955 dbSNP
rs1001122660 965 dbSNP
rs1485124373 968 dbSNP
rs1262878851 970 dbSNP
rs967376941 972 dbSNP
rs1489403403 981 dbSNP
rs1289781335 988 dbSNP
rs1244244930 993 dbSNP
rs998894160 994 dbSNP
rs895546884 996 dbSNP
rs538420273 1000 dbSNP
rs558424744 1014 dbSNP
rs1025128376 1015 dbSNP
rs967389894 1019 dbSNP
rs578180418 1021 dbSNP
rs1297379595 1025 dbSNP
rs1400319256 1032 dbSNP
rs1244978331 1036 dbSNP
rs1181220023 1037 dbSNP
rs1300897793 1038 dbSNP
rs1457019184 1040 dbSNP
rs1349929445 1041 dbSNP
rs1478961004 1048 dbSNP
rs957460296 1058 dbSNP
rs1427288957 1061 dbSNP
rs1415514548 1063 dbSNP
rs1474284691 1073 dbSNP
rs989233957 1079 dbSNP
rs978367961 1088 dbSNP
rs1032379144 1097 dbSNP
rs921806598 1098 dbSNP
rs953388673 1104 dbSNP
rs1479007152 1108 dbSNP
rs1407312032 1109 dbSNP
rs958034614 1111 dbSNP
rs1488871501 1115 dbSNP
rs1267336888 1121 dbSNP
rs974715859 1126 dbSNP
rs766899104 1133 dbSNP
rs922022414 1136 dbSNP
rs1219082290 1137 dbSNP
rs987433584 1137 dbSNP
rs911528337 1143 dbSNP
rs940375411 1144 dbSNP
rs1036103569 1151 dbSNP
rs1385842014 1152 dbSNP
rs1424431871 1152 dbSNP
rs149684500 1158 dbSNP
rs543805345 1164 dbSNP
rs755979979 1164 dbSNP
rs1459967842 1172 dbSNP
rs1400299831 1174 dbSNP
rs1171999769 1176 dbSNP
rs1467561044 1178 dbSNP
rs1427602643 1182 dbSNP
rs920306297 1183 dbSNP
rs1198549506 1184 dbSNP
rs953504300 1185 dbSNP
rs1175560218 1188 dbSNP
rs780000201 1190 dbSNP
rs1457367115 1199 dbSNP
rs369308860 1202 dbSNP
rs1257406466 1209 dbSNP
rs930400627 1210 dbSNP
rs377757070 1211 dbSNP
rs907697454 1220 dbSNP
rs1375562451 1222 dbSNP
rs772899005 1225 dbSNP
rs940637216 1225 dbSNP
rs1037630911 1228 dbSNP
rs1302953182 1232 dbSNP
rs1444017094 1233 dbSNP
rs867933065 1235 dbSNP
rs1375495637 1243 dbSNP
rs1395275863 1253 dbSNP
rs1056340487 1256 dbSNP
rs1237243417 1270 dbSNP
rs1449690698 1276 dbSNP
rs894673966 1278 dbSNP
rs1379654646 1284 dbSNP
rs879640647 1284 dbSNP
rs937027551 1284 dbSNP
rs1055360375 1285 dbSNP
rs1014903657 1287 dbSNP
rs1046021907 1291 dbSNP
rs903184471 1297 dbSNP
rs1253919300 1298 dbSNP
rs79714411 1299 dbSNP
rs1209089449 1311 dbSNP
rs1345441246 1313 dbSNP
rs1013986831 1316 dbSNP
rs371039006 1317 dbSNP
rs998778216 1322 dbSNP
rs1453303960 1323 dbSNP
rs1032976318 1324 dbSNP
rs1339234189 1338 dbSNP
rs1334078089 1345 dbSNP
rs752271057 1346 dbSNP
rs1232190782 1348 dbSNP
rs957427782 1351 dbSNP
rs1404772271 1353 dbSNP
rs996954125 1357 dbSNP
rs1419358265 1361 dbSNP
rs144483343 1362 dbSNP
rs953260677 1363 dbSNP
rs1160542752 1365 dbSNP
rs1442855024 1369 dbSNP
rs560627391 1386 dbSNP
rs537033623 1390 dbSNP
rs113432207 1391 dbSNP
rs181513793 1393 dbSNP
rs1161883703 1395 dbSNP
rs1258049555 1400 dbSNP
rs961960745 1406 dbSNP
rs971702339 1407 dbSNP
rs1286207525 1409 dbSNP
rs1241769349 1419 dbSNP
rs1353628152 1421 dbSNP
rs1284178044 1427 dbSNP
rs1393360761 1428 dbSNP
rs184601437 1442 dbSNP
rs1342738729 1451 dbSNP
rs1276718531 1452 dbSNP
rs987565634 1460 dbSNP
rs1328779293 1468 dbSNP
rs907917528 1469 dbSNP
rs930368070 1476 dbSNP
rs778023921 1495 dbSNP
rs1403728465 1496 dbSNP
rs916063750 1503 dbSNP
rs1444012056 1515 dbSNP
rs950281970 1516 dbSNP
rs1046328738 1523 dbSNP
rs903406873 1524 dbSNP
rs1191245392 1528 dbSNP
rs1477371424 1540 dbSNP
rs920526166 1546 dbSNP
rs999080826 1549 dbSNP
rs1054356884 1552 dbSNP
rs893166246 1554 dbSNP
rs531716580 1555 dbSNP
rs1358240087 1562 dbSNP
rs1210142742 1565 dbSNP
rs916921938 1566 dbSNP
rs1257359201 1567 dbSNP
rs949874928 1567 dbSNP
rs1041476544 1568 dbSNP
rs1456373865 1568 dbSNP
rs1341501082 1569 dbSNP
rs1028446295 1571 dbSNP
rs1434626810 1572 dbSNP
rs888937508 1583 dbSNP
rs1008695181 1589 dbSNP
rs1407089612 1591 dbSNP
rs1444036082 1594 dbSNP
rs1168428734 1596 dbSNP
rs1053943253 1601 dbSNP
rs1424032426 1604 dbSNP
rs894084077 1608 dbSNP
rs996425959 1609 dbSNP
rs1245706601 1615 dbSNP
rs1018790039 1617 dbSNP
rs1473339059 1618 dbSNP
rs1256771343 1620 dbSNP
rs1198540465 1621 dbSNP
rs1029031533 1622 dbSNP
rs56242923 1622 dbSNP
rs954740543 1622 dbSNP
rs550342028 1629 dbSNP
rs1275659835 1633 dbSNP
rs28740912 1633 dbSNP
rs1422192243 1634 dbSNP
rs1015027630 1642 dbSNP
rs1329274759 1642 dbSNP
rs972006463 1644 dbSNP
rs1332848629 1646 dbSNP
rs1400880499 1648 dbSNP
rs1172284131 1649 dbSNP
rs533072729 1651 dbSNP
rs546826022 1655 dbSNP
rs973239564 1657 dbSNP
rs951786124 1659 dbSNP
rs1172780761 1664 dbSNP
rs1331794526 1666 dbSNP
rs1027427450 1667 dbSNP
rs1455227674 1667 dbSNP
rs188521147 1675 dbSNP
rs1458616945 1684 dbSNP
rs1240499236 1685 dbSNP
rs1245313545 1688 dbSNP
rs1442194614 1689 dbSNP
rs1279662274 1690 dbSNP
rs915630038 1692 dbSNP
rs144390384 1695 dbSNP
rs981610498 1696 dbSNP
rs1220420580 1698 dbSNP
rs1308651405 1698 dbSNP
rs879611331 1706 dbSNP
rs934900638 1708 dbSNP
rs977470697 1711 dbSNP
rs924412234 1715 dbSNP
rs1054658339 1716 dbSNP
rs1436228563 1722 dbSNP
rs1378041597 1724 dbSNP
rs1482971442 1725 dbSNP
rs893134876 1728 dbSNP
rs1258604354 1730 dbSNP
rs932701612 1736 dbSNP
rs181389453 1744 dbSNP
rs1238443944 1750 dbSNP
rs1354073959 1750 dbSNP
rs1213403188 1751 dbSNP
rs1285491445 1754 dbSNP
rs1487438645 1754 dbSNP
rs891169483 1755 dbSNP
rs1478978628 1756 dbSNP
rs1172051888 1758 dbSNP
rs1429119494 1766 dbSNP
rs1465118315 1767 dbSNP
rs1378291352 1776 dbSNP
rs932103509 1785 dbSNP
rs1416322669 1786 dbSNP
rs1403987627 1787 dbSNP
rs1396216928 1788 dbSNP
rs1297152318 1789 dbSNP
rs568959013 1789 dbSNP
rs771313105 1791 dbSNP
rs1162043373 1794 dbSNP
rs1018778701 1801 dbSNP
rs781349865 1803 dbSNP
rs1415085879 1808 dbSNP
rs1190519740 1809 dbSNP
rs1278781615 1830 dbSNP
rs1262811522 1842 dbSNP
rs1015327321 1843 dbSNP
rs112539902 1852 dbSNP
rs1311522025 1852 dbSNP
rs775726072 1853 dbSNP
rs1263783560 1854 dbSNP
rs2156557 1854 dbSNP
rs994880329 1854 dbSNP
rs1257803837 1855 dbSNP
rs1027607841 1858 dbSNP
rs1234973878 1861 dbSNP
rs1346037475 1864 dbSNP
rs952064957 1872 dbSNP
rs1363569878 1881 dbSNP
rs1291297248 1882 dbSNP
rs958541704 1884 dbSNP
rs753556591 1893 dbSNP
rs1167719826 1894 dbSNP
rs991131483 1896 dbSNP
rs1194782113 1900 dbSNP
rs991245629 1900 dbSNP
rs1023071987 1908 dbSNP
rs1194764139 1913 dbSNP
rs1265452396 1914 dbSNP
rs971141871 1917 dbSNP
rs981185424 1918 dbSNP
rs1431937546 1919 dbSNP
rs1196176230 1934 dbSNP
rs1378887453 1936 dbSNP
rs924763323 1940 dbSNP
rs1253601774 1947 dbSNP
rs186531186 1948 dbSNP
rs578090427 1955 dbSNP
rs971705222 1956 dbSNP
rs1257210990 1962 dbSNP
rs1157684070 1977 dbSNP
rs146648755 1984 dbSNP
rs1298734131 1987 dbSNP
rs1385789142 1991 dbSNP
rs924267416 1994 dbSNP
rs1328564392 1998 dbSNP
rs1400136357 2006 dbSNP
rs1445249458 2006 dbSNP
rs1171837407 2009 dbSNP
rs1463848875 2018 dbSNP
rs935768962 2029 dbSNP
rs989906654 2039 dbSNP
rs1298578743 2046 dbSNP
rs1175604265 2049 dbSNP
rs1366872680 2053 dbSNP
rs1384985071 2055 dbSNP
rs1397003559 2056 dbSNP
rs932896424 2058 dbSNP
rs1456395493 2063 dbSNP
rs1237418104 2073 dbSNP
rs1331784127 2074 dbSNP
rs1049723923 2075 dbSNP
rs1481485155 2078 dbSNP
rs554413559 2080 dbSNP
rs1356104073 2081 dbSNP
rs944120768 2085 dbSNP
rs1217888290 2086 dbSNP
rs1376897615 2087 dbSNP
rs574272862 2091 dbSNP
rs1265191428 2093 dbSNP
rs1487817520 2095 dbSNP
rs1330133631 2111 dbSNP
rs932156210 2118 dbSNP
rs1037158621 2128 dbSNP
rs1302595548 2131 dbSNP
rs770381578 2137 dbSNP
rs993296787 2138 dbSNP
rs776191114 2141 dbSNP
rs1439153962 2142 dbSNP
rs890743488 2150 dbSNP
rs1182407099 2157 dbSNP
rs1378172812 2159 dbSNP
rs755232710 2169 dbSNP
rs1159626673 2183 dbSNP
rs1253852399 2184 dbSNP
rs1199609149 2195 dbSNP
rs1485797910 2198 dbSNP
rs1282018040 2200 dbSNP
rs1213899407 2203 dbSNP
rs887678471 2213 dbSNP
rs1352308863 2227 dbSNP
rs1013263044 2233 dbSNP
rs1241851434 2234 dbSNP
rs1339179481 2246 dbSNP
rs1312473659 2252 dbSNP
rs1036405312 2261 dbSNP
rs1456161539 2263 dbSNP
rs1022615909 2264 dbSNP
rs897824050 2267 dbSNP
rs56377761 2268 dbSNP
rs562574634 2269 dbSNP
rs1002575067 2272 dbSNP
rs1361210873 2281 dbSNP
rs1446204541 2286 dbSNP
rs1307169948 2288 dbSNP
rs1186659769 2289 dbSNP
rs1455301926 2289 dbSNP
rs1491339147 2289 dbSNP
rs1031415159 2290 dbSNP
rs1206322368 2290 dbSNP
rs1234343004 2290 dbSNP
rs1265363561 2290 dbSNP
rs1276586788 2290 dbSNP
rs1327194563 2290 dbSNP
rs1357734747 2290 dbSNP
rs1385153681 2290 dbSNP
rs1388564645 2290 dbSNP
rs1399661141 2290 dbSNP
rs1486639552 2290 dbSNP
rs1491244258 2290 dbSNP
rs149515303 2290 dbSNP
rs529047069 2290 dbSNP
rs56754076 2290 dbSNP
rs1241114812 2291 dbSNP
rs1164101986 2292 dbSNP
rs955796007 2293 dbSNP
rs990235847 2296 dbSNP
rs894542823 2298 dbSNP
rs1477300519 2299 dbSNP
rs1242269041 2300 dbSNP
rs914741880 2301 dbSNP
rs943996076 2302 dbSNP
rs868522589 2303 dbSNP
rs576116466 2304 dbSNP
rs1197504947 2305 dbSNP
rs1235805253 2308 dbSNP
rs1012719078 2309 dbSNP
rs1458679233 2311 dbSNP
rs1330566533 2313 dbSNP
rs1177457262 2314 dbSNP
rs944055942 2314 dbSNP
rs1412536152 2315 dbSNP
rs1396528232 2316 dbSNP
rs1469061687 2316 dbSNP
rs936405879 2317 dbSNP
rs1166631764 2319 dbSNP
rs1409148569 2320 dbSNP
rs1418568599 2321 dbSNP
rs1465007134 2323 dbSNP
rs1329445301 2328 dbSNP
rs1169260169 2334 dbSNP
rs1476778718 2337 dbSNP
rs1393988699 2343 dbSNP
rs1193659429 2353 dbSNP
rs1402571559 2359 dbSNP
rs1442940377 2360 dbSNP
rs1438729791 2362 dbSNP
rs1275429659 2363 dbSNP
rs1302503569 2365 dbSNP
rs971375899 2368 dbSNP
rs1037044018 2373 dbSNP
rs1344525641 2378 dbSNP
rs1304274377 2381 dbSNP
rs1236505769 2387 dbSNP
rs1373182552 2388 dbSNP
rs191002408 2390 dbSNP
rs141378151 2392 dbSNP
rs1313847197 2393 dbSNP
rs1354864236 2407 dbSNP
rs1412422748 2422 dbSNP
rs1048898063 2424 dbSNP
rs533107903 2425 dbSNP
rs1455185336 2431 dbSNP
rs1379057113 2432 dbSNP
rs1177105280 2437 dbSNP
rs1317887437 2442 dbSNP
rs957028236 2447 dbSNP
rs181023616 2451 dbSNP
rs1442069904 2453 dbSNP
rs1281297943 2455 dbSNP
rs1213180642 2456 dbSNP
rs1351565858 2457 dbSNP
rs921028277 2459 dbSNP
rs1223178236 2466 dbSNP
rs1260506139 2467 dbSNP
rs1373905614 2471 dbSNP
rs774043781 2472 dbSNP
rs1445454488 2482 dbSNP
rs1354492555 2489 dbSNP
rs906860082 2490 dbSNP
rs1436088305 2494 dbSNP
rs1358110287 2498 dbSNP
rs1410912504 2499 dbSNP
rs953762734 2505 dbSNP
rs1002457567 2506 dbSNP
rs1401813901 2513 dbSNP
rs986340362 2516 dbSNP
rs187272761 2517 dbSNP
rs912045091 2524 dbSNP
rs529208852 2528 dbSNP
rs1258543258 2530 dbSNP
rs761314838 2531 dbSNP
rs955763816 2533 dbSNP
rs548990820 2542 dbSNP
rs1487405991 2548 dbSNP
rs117066915 2553 dbSNP
rs1477342902 2554 dbSNP
rs1021778671 2558 dbSNP
rs919472917 2559 dbSNP
rs1333845194 2563 dbSNP
rs930666116 2563 dbSNP
rs1293639091 2566 dbSNP
rs750180303 2567 dbSNP
rs531339194 2571 dbSNP
rs1417228157 2572 dbSNP
rs1287788800 2581 dbSNP
rs985724380 2582 dbSNP
rs1347520497 2584 dbSNP
rs1410664483 2585 dbSNP
rs912773960 2586 dbSNP
rs965622448 2591 dbSNP
rs972706096 2592 dbSNP
rs1357686084 2597 dbSNP
rs1476970853 2600 dbSNP
rs78850454 2607 dbSNP
rs1045601910 2610 dbSNP
rs1187252537 2622 dbSNP
rs1486877478 2626 dbSNP
rs918605034 2627 dbSNP
rs9954575 2629 dbSNP
rs9950150 2635 dbSNP
rs1234835664 2644 dbSNP
rs753812805 2647 dbSNP
rs1294394685 2652 dbSNP
rs534376812 2654 dbSNP
rs554097773 2656 dbSNP
rs957245397 2660 dbSNP
rs1214692768 2664 dbSNP
rs567930069 2668 dbSNP
rs1291247453 2669 dbSNP
rs1440846112 2672 dbSNP
rs948593669 2683 dbSNP
rs1044242228 2687 dbSNP
rs1328350085 2696 dbSNP
rs1464388089 2709 dbSNP
rs1372780494 2710 dbSNP
rs907088412 2713 dbSNP
rs938617251 2714 dbSNP
rs1214714510 2715 dbSNP
rs1171359213 2718 dbSNP
rs1430481791 2721 dbSNP
rs1011275713 2737 dbSNP
rs1052688772 2739 dbSNP
rs1253548777 2753 dbSNP
rs1215399832 2759 dbSNP
rs891487992 2759 dbSNP
rs1027974484 2775 dbSNP
rs1250448684 2776 dbSNP
rs374023534 2777 dbSNP
rs1011281075 2781 dbSNP
rs1308841525 2782 dbSNP
rs1325354003 2787 dbSNP
rs1232837042 2788 dbSNP
rs986947914 2795 dbSNP
rs1306252301 2803 dbSNP
rs143600627 2804 dbSNP
rs758499821 2814 dbSNP
rs889553298 2819 dbSNP
rs1299054501 2827 dbSNP
rs912280328 2835 dbSNP
rs1357578649 2853 dbSNP
rs1007431573 2855 dbSNP
rs1019800129 2856 dbSNP
rs73427762 2858 dbSNP
rs972236297 2859 dbSNP
rs1190735792 2863 dbSNP
rs1417189028 2870 dbSNP
rs1423181499 2875 dbSNP
rs1177508471 2881 dbSNP
rs1481412617 2882 dbSNP
rs1277744318 2884 dbSNP
rs1209599496 2887 dbSNP
rs1347944723 2888 dbSNP
rs1416205888 2890 dbSNP
rs1281795930 2896 dbSNP
rs1237552585 2901 dbSNP
rs575982076 2902 dbSNP
rs919525337 2906 dbSNP
rs1308168616 2907 dbSNP
rs1393501327 2910 dbSNP
rs930886350 2912 dbSNP
rs1312478417 2932 dbSNP
rs1360070142 2935 dbSNP
rs151240741 2936 dbSNP
rs1156874374 2947 dbSNP
rs114943222 2948 dbSNP
rs2847124 2950 dbSNP
rs984212447 2961 dbSNP
rs916617043 2965 dbSNP
rs948163769 2968 dbSNP
rs1420641136 2972 dbSNP
rs557553779 2975 dbSNP
rs1186820132 2978 dbSNP
rs1485766794 2978 dbSNP
rs907260989 2980 dbSNP
rs999106638 3004 dbSNP
rs1350675565 3014 dbSNP
rs1261814803 3018 dbSNP
rs1436359902 3022 dbSNP
rs928482270 3036 dbSNP
rs938586312 3037 dbSNP
rs373526779 3042 dbSNP
rs1384234770 3045 dbSNP
rs560129268 3055 dbSNP
rs1455189914 3064 dbSNP
rs190965928 3072 dbSNP
rs1303772378 3077 dbSNP
rs1352525075 3078 dbSNP
rs1415425301 3081 dbSNP
rs1163869788 3083 dbSNP
rs1475334305 3089 dbSNP
rs1214234132 3090 dbSNP
rs747071896 3093 dbSNP
rs529198885 3096 dbSNP
rs891456928 3098 dbSNP
rs1011497574 3099 dbSNP
rs1207439375 3099 dbSNP
rs1028026807 3112 dbSNP
rs1479055701 3122 dbSNP
rs889459159 3133 dbSNP
rs1194324879 3149 dbSNP
rs947009684 3153 dbSNP
rs1337307245 3158 dbSNP
rs182757456 3166 dbSNP
rs889511487 3168 dbSNP
rs1226848976 3172 dbSNP
rs112357533 3178 dbSNP
rs961126659 3180 dbSNP
rs531300036 3191 dbSNP
rs1325055039 3193 dbSNP
rs972672828 3193 dbSNP
rs1012335616 3194 dbSNP
rs1461759162 3195 dbSNP
rs1020188687 3196 dbSNP
rs1165767108 3197 dbSNP
rs901364536 3204 dbSNP
rs994418459 3212 dbSNP
rs1194620697 3215 dbSNP
rs1453118466 3223 dbSNP
rs1026436222 3227 dbSNP
rs757351561 3236 dbSNP
rs1470087631 3237 dbSNP
rs952948004 3243 dbSNP
rs1271196284 3244 dbSNP
rs113402101 3245 dbSNP
rs1340252152 3246 dbSNP
rs1272005196 3247 dbSNP
rs916123475 3258 dbSNP
rs140435612 3263 dbSNP
rs1302562389 3266 dbSNP
rs527426715 3270 dbSNP
rs78911809 3278 dbSNP
rs981437137 3280 dbSNP
rs969847173 3281 dbSNP
rs928740717 3287 dbSNP
rs1326547632 3291 dbSNP
rs547958990 3304 dbSNP
rs1409021020 3305 dbSNP
rs1352111824 3308 dbSNP
rs982245450 3309 dbSNP
rs934744140 3313 dbSNP
rs1395062780 3315 dbSNP
rs1194769179 3318 dbSNP
rs1212724017 3318 dbSNP
rs1231543326 3319 dbSNP
rs1234962709 3319 dbSNP
rs1281082553 3319 dbSNP
rs1491049188 3319 dbSNP
rs563564371 3319 dbSNP
rs58014159 3319 dbSNP
rs764360084 3319 dbSNP
rs866558419 3319 dbSNP
rs1369563458 3320 dbSNP
rs76030405 3321 dbSNP
rs1277556776 3325 dbSNP
rs1303467327 3328 dbSNP
rs1052979268 3333 dbSNP
rs1309445111 3334 dbSNP
rs1374353118 3335 dbSNP
rs928470822 3335 dbSNP
rs947170463 3335 dbSNP
rs1416661035 3336 dbSNP
rs1049677313 3337 dbSNP
rs1158412201 3340 dbSNP
rs1470705531 3342 dbSNP
rs889689002 3348 dbSNP
rs1186120238 3351 dbSNP
rs150438630 3354 dbSNP
rs988614531 3356 dbSNP
rs913114249 3362 dbSNP
rs1313945041 3374 dbSNP
rs1019266126 3384 dbSNP
rs947344469 3385 dbSNP
rs1043086259 3387 dbSNP
rs1289939223 3389 dbSNP
rs1412562991 3393 dbSNP
rs543049354 3396 dbSNP
rs1313029059 3402 dbSNP
rs952214335 3405 dbSNP
rs910919577 3411 dbSNP
rs942426176 3415 dbSNP
rs1040855109 3416 dbSNP
rs1287710962 3418 dbSNP
rs1469761731 3424 dbSNP
rs1023650974 3430 dbSNP
rs1318215536 3442 dbSNP
rs970321913 3446 dbSNP
rs1214440889 3450 dbSNP
rs1163159896 3452 dbSNP
rs901333254 3453 dbSNP
rs1475003658 3455 dbSNP
rs1237613427 3456 dbSNP
rs1418838172 3457 dbSNP
rs981872852 3484 dbSNP
rs1484920037 3489 dbSNP
rs994303382 3495 dbSNP
rs928650735 3503 dbSNP
rs934775924 3504 dbSNP
rs1269799943 3515 dbSNP
rs1231222437 3517 dbSNP
rs1047263272 3522 dbSNP
rs536450462 3526 dbSNP
rs189919875 3527 dbSNP
rs914621384 3529 dbSNP
rs1359297443 3530 dbSNP
rs781505838 3537 dbSNP
rs1287728544 3552 dbSNP
rs746099827 3563 dbSNP
rs1049562755 3564 dbSNP
rs1324382253 3565 dbSNP
rs1461241197 3568 dbSNP
rs1395558690 3570 dbSNP
rs1167142296 3571 dbSNP
rs1426923132 3577 dbSNP
rs570028665 3587 dbSNP
rs1418923070 3588 dbSNP
rs1187124709 3590 dbSNP
rs562019620 3598 dbSNP
rs1249800861 3599 dbSNP
rs1211639294 3601 dbSNP
rs1161825108 3602 dbSNP
rs1416645955 3604 dbSNP
rs1223343226 3605 dbSNP
rs1024043003 3607 dbSNP
rs943952579 3610 dbSNP
rs1294233131 3627 dbSNP
rs558717139 3645 dbSNP
rs530800324 3649 dbSNP
rs1462409410 3650 dbSNP
rs762921979 3654 dbSNP
rs969437890 3654 dbSNP
rs1331207648 3656 dbSNP
rs1372222890 3676 dbSNP
rs1295605892 3681 dbSNP
rs572493752 3682 dbSNP
rs1171292911 3684 dbSNP
rs1443854444 3684 dbSNP
rs1330493986 3685 dbSNP
rs1192639095 3688 dbSNP
rs1250404596 3688 dbSNP
rs1391991608 3688 dbSNP
rs1479490198 3688 dbSNP
rs549010044 3688 dbSNP
rs993753867 3690 dbSNP
rs796222512 3692 dbSNP
rs8095809 3693 dbSNP
rs1234232406 3694 dbSNP
rs1332124285 3695 dbSNP
rs868728538 3698 dbSNP
rs888166450 3702 dbSNP
rs865781780 3703 dbSNP
rs138210213 3706 dbSNP
rs542861839 3707 dbSNP
rs1316146482 3708 dbSNP
rs1373730263 3708 dbSNP
rs969026981 3711 dbSNP
rs1197569280 3712 dbSNP
rs1378125481 3713 dbSNP
rs1434027680 3713 dbSNP
rs202192298 3714 dbSNP
rs1442029639 3715 dbSNP
rs373150350 3716 dbSNP
rs377258556 3716 dbSNP
rs1185935621 3717 dbSNP
rs1483805248 3717 dbSNP
rs1230474831 3718 dbSNP
rs1289320537 3718 dbSNP
rs773285397 3718 dbSNP
rs1312418975 3719 dbSNP
rs1353721504 3719 dbSNP
rs1451493955 3720 dbSNP
rs762709657 3720 dbSNP
rs1473371583 3721 dbSNP
rs868858000 3721 dbSNP
rs1415205384 3722 dbSNP
rs551883466 3723 dbSNP
rs1422037829 3728 dbSNP
rs1442464774 3729 dbSNP
rs963555988 3732 dbSNP
rs1169137897 3733 dbSNP
rs1396814664 3734 dbSNP
rs1395067910 3739 dbSNP
rs1203918452 3740 dbSNP
rs1331731069 3744 dbSNP
rs970755267 3745 dbSNP
rs1210960921 3749 dbSNP
rs1333034244 3752 dbSNP
rs1292886897 3753 dbSNP
rs1245670420 3759 dbSNP
rs994890950 3766 dbSNP
rs1342377993 3767 dbSNP
rs1029498270 3774 dbSNP
rs1003119262 3778 dbSNP
rs141385075 3782 dbSNP
rs1277499247 3783 dbSNP
rs1391887265 3791 dbSNP
rs910877773 3799 dbSNP
rs1472893408 3805 dbSNP
rs942413522 3806 dbSNP
rs183259352 3807 dbSNP
rs1428510036 3814 dbSNP
rs544971474 3815 dbSNP
rs1338335275 3823 dbSNP
rs1229758592 3824 dbSNP
rs922307249 3833 dbSNP
rs756589617 3838 dbSNP
rs780704547 3839 dbSNP
rs1251947537 3845 dbSNP
rs929728160 3846 dbSNP
rs956028574 3854 dbSNP
rs988788763 3858 dbSNP
rs1226780226 3863 dbSNP
rs1364445292 3870 dbSNP
rs1298203728 3873 dbSNP
rs564766444 3874 dbSNP
rs1486212290 3879 dbSNP
rs888649044 3887 dbSNP
rs1322578034 3888 dbSNP
rs968778750 3890 dbSNP
rs985316679 3893 dbSNP
rs146972121 3897 dbSNP
rs1261739904 3903 dbSNP
rs1428509674 3903 dbSNP
rs1045356893 3904 dbSNP
rs1391372619 3907 dbSNP
rs547130980 3914 dbSNP
rs1252781716 3919 dbSNP
rs1040968307 3920 dbSNP
rs1194760389 3924 dbSNP
rs768289338 3928 dbSNP
rs1195349183 3929 dbSNP
rs1343001873 3932 dbSNP
rs377172618 3934 dbSNP
rs761553961 3935 dbSNP
rs1345559594 3940 dbSNP
rs1274096086 3942 dbSNP
rs888219309 3946 dbSNP
rs560658804 3948 dbSNP
rs530197176 3949 dbSNP
rs956760487 3954 dbSNP
rs1009635833 3956 dbSNP
rs1370664540 3957 dbSNP
rs1376831721 3959 dbSNP
rs1020519717 3960 dbSNP
rs968621248 3964 dbSNP
rs1044992557 3965 dbSNP
rs906039429 3972 dbSNP
rs1297325121 3978 dbSNP
rs979078160 3982 dbSNP
rs549982585 3988 dbSNP
rs570000488 3990 dbSNP
rs1254073411 3991 dbSNP
rs538988981 3992 dbSNP
rs964307716 3993 dbSNP
rs1277797053 3997 dbSNP
rs1219625199 4002 dbSNP
rs188140492 4003 dbSNP
rs138212685 4004 dbSNP
rs1305975147 4005 dbSNP
rs570040574 4006 dbSNP
rs554734867 4008 dbSNP
rs192664824 4009 dbSNP
rs114780611 4010 dbSNP
rs941506316 4012 dbSNP
rs1045644909 4013 dbSNP
rs1406257443 4014 dbSNP
rs1158803024 4017 dbSNP
rs1473079366 4019 dbSNP
rs965258305 4030 dbSNP
rs1185958599 4036 dbSNP
rs1472488612 4039 dbSNP
rs1206269063 4044 dbSNP
rs976960953 4056 dbSNP
rs905423356 4057 dbSNP
rs1267189823 4069 dbSNP
rs939620326 4073 dbSNP
rs1432104306 4086 dbSNP
rs1444013779 4087 dbSNP
rs1056378964 4090 dbSNP
rs530977599 4093 dbSNP
rs918531721 4102 dbSNP
rs1048088247 4103 dbSNP
rs929875962 4103 dbSNP
rs1289811359 4104 dbSNP
rs760177616 4107 dbSNP
rs909544097 4108 dbSNP
rs1284215288 4113 dbSNP
rs1450819518 4114 dbSNP
rs892490497 4115 dbSNP
rs1191187357 4116 dbSNP
rs1009606200 4121 dbSNP
rs1458072128 4125 dbSNP
rs1391153034 4138 dbSNP
rs1163086001 4139 dbSNP
rs113546734 4142 dbSNP
rs1414650563 4144 dbSNP
rs143694254 4154 dbSNP
rs1246101994 4157 dbSNP
rs1187753525 4159 dbSNP
rs1022413048 4161 dbSNP
rs1465156564 4169 dbSNP
rs1044823904 4173 dbSNP
rs1218944601 4176 dbSNP
rs371368102 4178 dbSNP
rs999992821 4181 dbSNP
rs773668363 4187 dbSNP
rs1018541903 4188 dbSNP
rs747725885 4190 dbSNP
rs576393219 4192 dbSNP
rs1029312750 4199 dbSNP
rs1297466923 4200 dbSNP
rs545019088 4201 dbSNP
rs982454090 4208 dbSNP
rs1367818684 4212 dbSNP
rs1455091912 4212 dbSNP
rs909595232 4223 dbSNP
rs1389911202 4224 dbSNP
rs1385231329 4234 dbSNP
rs116580198 4239 dbSNP
rs1010492215 4247 dbSNP
rs1408256144 4249 dbSNP
rs1388292703 4253 dbSNP
rs980936032 4255 dbSNP
rs1021671163 4257 dbSNP
rs1449941192 4264 dbSNP
rs904524803 4272 dbSNP
rs1007277695 4274 dbSNP
rs1018371547 4275 dbSNP
rs1246900784 4276 dbSNP
rs1223176491 4282 dbSNP
rs1339489107 4287 dbSNP
rs143882283 4291 dbSNP
rs1229808824 4293 dbSNP
rs541037356 4306 dbSNP
rs12953660 4307 dbSNP
rs1319106727 4315 dbSNP
rs1056682156 4317 dbSNP
rs1240131176 4330 dbSNP
rs1265426470 4337 dbSNP
rs560620151 4340 dbSNP
rs1370055260 4344 dbSNP
rs1169225563 4346 dbSNP
rs1430400522 4347 dbSNP
rs976636314 4350 dbSNP
rs1173752332 4351 dbSNP
rs1025428502 4353 dbSNP
rs951332989 4357 dbSNP
rs1192589076 4359 dbSNP
rs1481834453 4359 dbSNP
rs1211335805 4362 dbSNP
rs1254363704 4367 dbSNP
rs984010461 4367 dbSNP
rs529765607 4370 dbSNP
rs1233037491 4372 dbSNP
rs1313185731 4374 dbSNP
rs1177634781 4378 dbSNP
rs1303802149 4378 dbSNP
rs1405271534 4380 dbSNP
rs1350095137 4381 dbSNP
rs1308774521 4382 dbSNP
rs1411716084 4383 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggaggagguccuaggUGUGu 5'
                           |||| 
Target 5' -----------------ACACg 3'
1 - 5
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000300413.5 | 3UTR | ACACGUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000300413.5 | 3UTR | ACACGUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.856 0.03 0.600 0.14 5 Click to see details
THCA -0.651 0.17 -0.800 0.1 4 Click to see details
HNSC 0.365 0.21 0.071 0.44 7 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
LUSC -0.08 0.46 -0.400 0.3 4 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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