pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CCR5   
Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Description C-C motif chemokine receptor 5 (gene/pseudogene)
Transcript NM_000579   
Other Transcripts NM_001100168   
Expression
Putative miRNA Targets on CCR5
3'UTR of CCR5
(miRNA target sites are highlighted)
>CCR5|NM_000579|3'UTR
   1 CACGGACTCAAGTGGGCTGGTGACCCAGTCAGAGTTGTGCACATGGCTTAGTTTTCATACACAGCCTGGGCTGGGGGTGG
  81 GGTGGGAGAGGTCTTTTTTAAAAGGAAGTTACTGTTATAGAGGGTCTAAGATTCATCCATTTATTTGGCATCTGTTTAAA
 161 GTAGATTAGATCTTTTAAGCCCATCAATTATAGAAAGCCAAATCAAAATATGTTGATGAAAAATAGCAACCTTTTTATCT
 241 CCCCTTCACATGCATCAAGTTATTGACAAACTCTCCCTTCACTCCGAAAGTTCCTTATGTATATTTAAAAGAAAGCCTCA
 321 GAGAATTGCTGATTCTTGAGTTTAGTGATCTGAACAGAAATACCAAAATTATTTCAGAAATGTACAACTTTTTACCTAGT
 401 ACAAGGCAACATATAGGTTGTAAATGTGTTTAAAACAGGTCTTTGTCTTGCTATGGGGAGAAAAGACATGAATATGATTA
 481 GTAAAGAAATGACACTTTTCATGTGTGATTTCCCCTCCAAGGTATGGTTAATAAGTTTCACTGACTTAGAACCAGGCGAG
 561 AGACTTGTGGCCTGGGAGAGCTGGGGAAGCTTCTTAAATGAGAAGGAATTTGAGTTGGATCATCTATTGCTGGCAAAGAC
 641 AGAAGCCTCACTGCAAGCACTGCATGGGCAAGCTTGGCTGTAGAAGGAGACAGAGCTGGTTGGGAAGACATGGGGAGGAA
 721 GGACAAGGCTAGATCATGAAGAACCTTGACGGCATTGCTCCGTCTAAGTCATGAGCTGAGCAGGGAGATCCTGGTTGGTG
 801 TTGCAGAAGGTTTACTCTGTGGCCAAAGGAGGGTCAGGAAGGATGAGCATTTAGGGCAAGGAGACCACCAACAGCCCTCA
 881 GGTCAGGGTGAGGATGGCCTCTGCTAAGCTCAAGGCGTGAGGATGGGAAGGAGGGAGGTATTCGTAAGGATGGGAAGGAG
 961 GGAGGTATTCGTGCAGCATATGAGGATGCAGAGTCAGCAGAACTGGGGTGGATTTGGGTTGGAAGTGAGGGTCAGAGAGG
1041 AGTCAGAGAGAATCCCTAGTCTTCAAGCAGATTGGAGAAACCCTTGAAAAGACATCAAGCACAGAAGGAGGAGGAGGAGG
1121 TTTAGGTCAAGAAGAAGATGGATTGGTGTAAAAGGATGGGTCTGGTTTGCAGAGCTTGAACACAGTCTCACCCAGACTCC
1201 AGGCTGTCTTTCACTGAATGCTTCTGACTTCATAGATTTCCTTCCCATCCCAGCTGAAATACTGAGGGGTCTCCAGGAGG
1281 AGACTAGATTTATGAATACACGAGGTATGAGGTCTAGGAACATACTTCAGCTCACACATGAGATCTAGGTGAGGATTGAT
1361 TACCTAGTAGTCATTTCATGGGTTGTTGGGAGGATTCTATGAGGCAACCACAGGCAGCATTTAGCACATACTACACATTC
1441 AATAAGCATCAAACTCTTAGTTACTCATTCAGGGATAGCACTGAGCAAAGCATTGAGCAAAGGGGTCCCATAGAGGTGAG
1521 GGAAGCCTGAAAAACTAAGATGCTGCCTGCCCAGTGCACACAAGTGTAGGTATCATTTTCTGCATTTAACCGTCAATAGG
1601 CAAAGGGGGGAAGGGACATATTCATTTGGAAATAAGCTGCCTTGAGCCTTAAAACCCACAAAAGTACAATTTACCAGCCT
1681 CCGTATTTCAGACTGAATGGGGGTGGGGGGGGCGCCTTAGGTACTTATTCCAGATGCCTTCTCCAGACAAACCAGAAGCA
1761 ACAGAAAAAATCGTCTCTCCCTCCCTTTGAAATGAATATACCCCTTAGTGTTTGGGTATATTCATTTCAAAGGGAGAGAG
1841 AGAGGTTTTTTTCTGTTCTGTCTCATATGATTGTGCACATACTTGAGACTGTTTTGAATTTGGGGGATGGCTAAAACCAT
1921 CATAGTACAGGTAAGGTGAGGGAATAGTAAGTGGTGAGAACTACTCAGGGAATGAAGGTGTCAGAATAATAAGAGGTGCT
2001 ACTGACTTTCTCAGCCTCTGAATATGAACGGTGAGCATTGTGGCTGTCAGCAGGAAGCAACGAAGGGAAATGTCTTTCCT
2081 TTTGCTCTTAAGTTGTGGAGAGTGCAACAGTAGCATAGGACCCTACCCTCTGGGCCAAGTCAAAGACATTCTGACATCTT
2161 AGTATTTGCATATTCTTATGTATGTGAAAGTTACAAATTGCTTGAAAGAAAATATGCATCTAATAAAAAACACCTTCTAA
2241 AATAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaUACCCACCCUGUCUCUCCc 5'
            | | | ||| |||||||| 
Target 5' ggAAGTGAGGGTCAGAGAGGa 3'
1021 - 1041 163.00 -19.70
2
miRNA  3' gauaCCCACCCUG-UCUCUCCc 5'
              |||||||:: :|||||| 
Target 5' ctggGGGTGGGGTGGGAGAGGt 3'
71 - 92 153.00 -27.90
3
miRNA  3' gauaccCACCCUGUCUCUCCc 5'
                | | || ||||||| 
Target 5' ttcaaaGGGAGAGAGAGAGGt 3'
1826 - 1846 151.00 -20.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30119253 4 COSMIC
COSN31565790 28 COSMIC
COSN30500319 36 COSMIC
COSN5806858 47 COSMIC
COSN26649907 65 COSMIC
COSN30535774 90 COSMIC
COSN14066660 94 COSMIC
COSN30107891 95 COSMIC
COSN8489281 96 COSMIC
COSN20069144 100 COSMIC
COSN30468581 106 COSMIC
COSN30108956 107 COSMIC
COSN30109488 111 COSMIC
COSN30534245 172 COSMIC
COSN30113659 247 COSMIC
COSN15623567 277 COSMIC
COSN31549456 281 COSMIC
COSN30129071 286 COSMIC
COSN31585001 336 COSMIC
COSN30528173 337 COSMIC
COSN30113932 343 COSMIC
COSN27165684 370 COSMIC
COSN15623568 419 COSMIC
COSN31515864 448 COSMIC
COSN30112471 582 COSMIC
COSN30139579 585 COSMIC
COSN31516170 625 COSMIC
COSN31577441 625 COSMIC
COSN15623569 688 COSMIC
COSN30175315 706 COSMIC
COSN30172997 714 COSMIC
COSN30132135 733 COSMIC
COSN15623570 779 COSMIC
COSN31533790 792 COSMIC
COSN19143812 808 COSMIC
COSN7699264 859 COSMIC
COSN15623571 861 COSMIC
COSN24012567 880 COSMIC
COSN28090631 888 COSMIC
COSN30139580 934 COSMIC
COSN30124614 944 COSMIC
COSN25376355 972 COSMIC
COSN30116585 1007 COSMIC
COSN28702119 1019 COSMIC
COSN30528311 1051 COSMIC
COSN24300039 1098 COSMIC
COSN26958357 1235 COSMIC
COSN31519280 1263 COSMIC
COSN26647338 1300 COSMIC
COSN15623572 1303 COSMIC
COSN15623573 1346 COSMIC
COSN8489282 1358 COSMIC
COSN9721071 1369 COSMIC
COSN6768987 1373 COSMIC
COSN26958358 1712 COSMIC
COSN15623574 1713 COSMIC
COSN30125438 1713 COSMIC
COSN15623575 1732 COSMIC
COSN31590814 1778 COSMIC
COSN15623576 1784 COSMIC
COSN229051 1815 COSMIC
COSN31608875 1863 COSMIC
COSN26481894 1867 COSMIC
COSN229050 1889 COSMIC
COSN25267025 1971 COSMIC
COSN26636738 2063 COSMIC
COSN31548177 2087 COSMIC
COSN28437931 2158 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs191297617 4 dbSNP
rs769213005 5 dbSNP
rs776859902 6 dbSNP
rs1193915539 12 dbSNP
rs764761704 17 dbSNP
rs532474349 20 dbSNP
rs540992448 22 dbSNP
rs1205026442 29 dbSNP
rs777009009 36 dbSNP
rs750032774 40 dbSNP
rs1438776850 41 dbSNP
rs544907003 42 dbSNP
rs762613473 47 dbSNP
rs1275613009 61 dbSNP
rs1226938158 62 dbSNP
rs1353907021 63 dbSNP
rs1283227132 65 dbSNP
rs1233385116 73 dbSNP
rs1356739404 74 dbSNP
rs536872608 76 dbSNP
rs1409081962 82 dbSNP
rs1355015549 84 dbSNP
rs867834481 89 dbSNP
rs1330687300 98 dbSNP
rs1001552690 106 dbSNP
rs1413414452 109 dbSNP
rs529752751 110 dbSNP
rs146080174 113 dbSNP
rs950293317 119 dbSNP
rs1409789724 122 dbSNP
rs1181524789 124 dbSNP
rs1481271694 128 dbSNP
rs1045742755 132 dbSNP
rs1235101403 138 dbSNP
rs1219903006 140 dbSNP
rs1451338956 144 dbSNP
rs1035658784 145 dbSNP
rs927305902 154 dbSNP
rs959996868 156 dbSNP
rs1470522583 166 dbSNP
rs1285964479 173 dbSNP
rs1179099070 174 dbSNP
rs1010142611 183 dbSNP
rs569458865 186 dbSNP
rs1434043830 188 dbSNP
rs1349051619 190 dbSNP
rs1054984862 192 dbSNP
rs112622745 195 dbSNP
rs752397660 197 dbSNP
rs1011121512 206 dbSNP
rs1158613973 212 dbSNP
rs978988121 213 dbSNP
rs1042213202 216 dbSNP
rs1189920634 225 dbSNP
rs1477922122 231 dbSNP
rs183840358 238 dbSNP
rs964152239 253 dbSNP
rs1339699622 254 dbSNP
rs1224020034 255 dbSNP
rs998083568 256 dbSNP
rs1469564632 263 dbSNP
rs1029273904 265 dbSNP
rs953749329 274 dbSNP
rs748287465 275 dbSNP
rs976456855 275 dbSNP
rs1286298685 277 dbSNP
rs1217360546 280 dbSNP
rs922268195 281 dbSNP
rs1303932410 282 dbSNP
rs552382275 283 dbSNP
rs570782804 286 dbSNP
rs764395007 287 dbSNP
rs41414147 291 dbSNP
rs1017056005 300 dbSNP
rs1414445021 316 dbSNP
rs962500340 322 dbSNP
rs973283640 330 dbSNP
rs568368266 333 dbSNP
rs1195966272 341 dbSNP
rs866115726 342 dbSNP
rs1038296493 347 dbSNP
rs1261813700 355 dbSNP
rs1245829120 357 dbSNP
rs763665714 358 dbSNP
rs535892345 362 dbSNP
rs143589063 364 dbSNP
rs1202225210 365 dbSNP
rs971625297 368 dbSNP
rs937434983 370 dbSNP
rs1057136344 381 dbSNP
rs1376345865 393 dbSNP
rs1477870478 402 dbSNP
rs575840249 419 dbSNP
rs1010175310 425 dbSNP
rs757414418 431 dbSNP
rs1339730727 436 dbSNP
rs1387358867 437 dbSNP
rs1417958317 442 dbSNP
rs1382939286 454 dbSNP
rs1364318866 457 dbSNP
rs927276137 458 dbSNP
rs543618933 459 dbSNP
rs574715855 468 dbSNP
rs990172616 477 dbSNP
rs1428225764 478 dbSNP
rs1405551298 481 dbSNP
rs914611071 483 dbSNP
rs904450707 487 dbSNP
rs1303300464 492 dbSNP
rs1428789711 497 dbSNP
rs369515918 500 dbSNP
rs1329142366 501 dbSNP
rs1232207340 503 dbSNP
rs1485028306 507 dbSNP
rs1279795999 509 dbSNP
rs1000094225 513 dbSNP
rs1237472087 520 dbSNP
rs1018526953 523 dbSNP
rs746407806 526 dbSNP
rs902385298 531 dbSNP
rs758790885 535 dbSNP
rs1227844755 536 dbSNP
rs1309552359 541 dbSNP
rs1310831411 542 dbSNP
rs1232767238 548 dbSNP
rs976529032 556 dbSNP
rs1051004188 558 dbSNP
rs577174845 559 dbSNP
rs1299169009 590 dbSNP
rs982459097 595 dbSNP
rs540976580 599 dbSNP
rs1451421814 603 dbSNP
rs1162269721 608 dbSNP
rs1006934213 615 dbSNP
rs1417893205 619 dbSNP
rs145725153 621 dbSNP
rs1189416181 627 dbSNP
rs942281977 641 dbSNP
rs973649425 646 dbSNP
rs373926603 653 dbSNP
rs541845196 654 dbSNP
rs937508540 670 dbSNP
rs1263906672 679 dbSNP
rs1057169382 682 dbSNP
rs780507054 684 dbSNP
rs1016614224 687 dbSNP
rs41495153 694 dbSNP
rs1226645493 699 dbSNP
rs142957506 700 dbSNP
rs1042129524 705 dbSNP
rs1308270499 712 dbSNP
rs1393511141 713 dbSNP
rs993960251 714 dbSNP
rs151122728 718 dbSNP
rs1000526601 722 dbSNP
rs1018181334 730 dbSNP
rs1166550773 735 dbSNP
rs375306827 738 dbSNP
rs570721731 751 dbSNP
rs528738443 752 dbSNP
rs1182351157 753 dbSNP
rs1420684767 759 dbSNP
rs971595718 763 dbSNP
rs17765882 765 dbSNP
rs1469128520 773 dbSNP
rs1034564144 780 dbSNP
rs1206919386 783 dbSNP
rs1349966679 784 dbSNP
rs41418945 785 dbSNP
rs41466044 788 dbSNP
rs982516435 793 dbSNP
rs1303178858 802 dbSNP
rs190456231 810 dbSNP
rs1329344896 811 dbSNP
rs1327428384 813 dbSNP
rs1378835950 817 dbSNP
rs528292132 827 dbSNP
rs1455319742 839 dbSNP
rs1393189458 843 dbSNP
rs914604184 848 dbSNP
rs1308008322 858 dbSNP
rs569344707 860 dbSNP
rs539953254 861 dbSNP
rs923775910 865 dbSNP
rs1359538184 869 dbSNP
rs1017021468 876 dbSNP
rs1255133431 878 dbSNP
rs1191254770 888 dbSNP
rs1446528141 909 dbSNP
rs962398258 917 dbSNP
rs773688575 918 dbSNP
rs1343569054 920 dbSNP
rs1280224376 925 dbSNP
rs759552801 926 dbSNP
rs889673627 933 dbSNP
rs942653235 944 dbSNP
rs41345848 945 dbSNP
rs141257116 947 dbSNP
rs993914395 950 dbSNP
rs1383400404 953 dbSNP
rs1025358229 958 dbSNP
rs906957203 962 dbSNP
rs200501663 971 dbSNP
rs1435140657 972 dbSNP
rs1243934892 977 dbSNP
rs1003011434 985 dbSNP
rs1034541077 986 dbSNP
rs201290180 987 dbSNP
rs990447158 988 dbSNP
rs199648605 991 dbSNP
rs775479176 999 dbSNP
rs977396948 1009 dbSNP
rs1800874 1019 dbSNP
rs946138055 1028 dbSNP
rs200364389 1029 dbSNP
rs1041770168 1031 dbSNP
rs1486869706 1031 dbSNP
rs1271386850 1032 dbSNP
rs954806119 1034 dbSNP
rs1444219059 1035 dbSNP
rs986574013 1040 dbSNP
rs1338411546 1042 dbSNP
rs201423367 1045 dbSNP
rs1270356449 1051 dbSNP
rs186889269 1057 dbSNP
rs1352979560 1064 dbSNP
rs1292624573 1066 dbSNP
rs936011928 1071 dbSNP
rs1040048384 1075 dbSNP
rs1038328361 1076 dbSNP
rs752632377 1077 dbSNP
rs919840033 1078 dbSNP
rs554321754 1080 dbSNP
rs1409137815 1082 dbSNP
rs1382998360 1083 dbSNP
rs146926765 1092 dbSNP
rs1474284595 1109 dbSNP
rs562961861 1111 dbSNP
rs1050919580 1116 dbSNP
rs1339360117 1117 dbSNP
rs1476495566 1126 dbSNP
rs574954754 1132 dbSNP
rs1228862216 1136 dbSNP
rs137866928 1147 dbSNP
rs1016681353 1156 dbSNP
rs1316480918 1163 dbSNP
rs41535253 1167 dbSNP
rs1001866233 1176 dbSNP
rs1484383515 1177 dbSNP
rs1233363577 1180 dbSNP
rs1180335941 1181 dbSNP
rs754123884 1188 dbSNP
rs1255634585 1190 dbSNP
rs1033279325 1195 dbSNP
rs1441210591 1204 dbSNP
rs528671807 1205 dbSNP
rs1429141573 1207 dbSNP
rs1194311028 1209 dbSNP
rs1331153903 1210 dbSNP
rs958964822 1212 dbSNP
rs1393980808 1231 dbSNP
rs41526948 1235 dbSNP
rs765388021 1242 dbSNP
rs1406433773 1244 dbSNP
rs77024144 1247 dbSNP
rs754748129 1251 dbSNP
rs967561308 1252 dbSNP
rs1406501247 1253 dbSNP
rs1235014084 1266 dbSNP
rs1467319577 1267 dbSNP
rs879705496 1268 dbSNP
rs1466914675 1269 dbSNP
rs1012242294 1273 dbSNP
rs1300699985 1281 dbSNP
rs750437295 1282 dbSNP
rs1213779912 1284 dbSNP
rs926039474 1295 dbSNP
rs758992399 1300 dbSNP
rs562220468 1301 dbSNP
rs529611447 1302 dbSNP
rs780412321 1303 dbSNP
rs1284406463 1309 dbSNP
rs1438434558 1317 dbSNP
rs550958125 1323 dbSNP
rs1208302078 1324 dbSNP
rs954775527 1329 dbSNP
rs1343460340 1331 dbSNP
rs1158452744 1332 dbSNP
rs921227972 1333 dbSNP
rs1401840181 1336 dbSNP
rs1410800948 1340 dbSNP
rs1486251240 1345 dbSNP
rs933906115 1354 dbSNP
rs747440437 1357 dbSNP
rs1261088416 1366 dbSNP
rs755342260 1373 dbSNP
rs546490087 1377 dbSNP
rs781480048 1385 dbSNP
rs963872977 1397 dbSNP
rs201417500 1399 dbSNP
rs3188094 1400 dbSNP
rs190094030 1404 dbSNP
rs1288059780 1409 dbSNP
rs551901023 1410 dbSNP
rs1346831955 1411 dbSNP
rs929893642 1420 dbSNP
rs1221205878 1425 dbSNP
rs181602248 1428 dbSNP
rs1434628268 1431 dbSNP
rs185327310 1432 dbSNP
rs1046745059 1437 dbSNP
rs928312880 1439 dbSNP
rs1288436759 1449 dbSNP
rs1431560095 1450 dbSNP
rs1347473549 1457 dbSNP
rs1002336871 1462 dbSNP
rs1033308638 1471 dbSNP
rs896121800 1473 dbSNP
rs534497551 1475 dbSNP
rs1434517809 1477 dbSNP
rs1396015023 1478 dbSNP
rs770453936 1479 dbSNP
rs1175891770 1481 dbSNP
rs1014493775 1482 dbSNP
rs1416941941 1482 dbSNP
rs1485870901 1490 dbSNP
rs1419907865 1493 dbSNP
rs1299542292 1497 dbSNP
rs553155294 1500 dbSNP
rs1399994393 1512 dbSNP
rs1048115 1514 dbSNP
rs1211972017 1518 dbSNP
rs1306045047 1527 dbSNP
rs1295058165 1529 dbSNP
rs967971747 1536 dbSNP
rs1304225786 1541 dbSNP
rs1291999695 1551 dbSNP
rs1414766118 1557 dbSNP
rs1376559446 1558 dbSNP
rs1055589703 1566 dbSNP
rs894221170 1576 dbSNP
rs1370190274 1577 dbSNP
rs1011714673 1593 dbSNP
rs1352413940 1602 dbSNP
rs1043630093 1603 dbSNP
rs141737357 1607 dbSNP
rs745351514 1610 dbSNP
rs1474880188 1611 dbSNP
rs1030276919 1612 dbSNP
rs41442546 1618 dbSNP
rs1007974539 1623 dbSNP
rs1479495221 1634 dbSNP
rs1017654850 1646 dbSNP
rs1205422850 1656 dbSNP
rs1320240781 1659 dbSNP
rs1487995327 1660 dbSNP
rs933979640 1665 dbSNP
rs1215821236 1670 dbSNP
rs775569353 1676 dbSNP
rs1247145886 1679 dbSNP
rs760628369 1683 dbSNP
rs1315372749 1684 dbSNP
rs963809196 1690 dbSNP
rs1372993708 1693 dbSNP
rs1299080595 1699 dbSNP
rs1162247047 1705 dbSNP
rs1402022244 1705 dbSNP
rs939905165 1705 dbSNP
rs556971174 1706 dbSNP
rs1439997164 1707 dbSNP
rs776525395 1708 dbSNP
rs1177535073 1710 dbSNP
rs574892806 1712 dbSNP
rs951261805 1713 dbSNP
rs1213157379 1714 dbSNP
rs190136403 1715 dbSNP
rs1267778590 1718 dbSNP
rs376306118 1721 dbSNP
rs778460868 1722 dbSNP
rs896193731 1723 dbSNP
rs938290724 1725 dbSNP
rs1166154074 1731 dbSNP
rs1352071675 1739 dbSNP
rs1024539428 1744 dbSNP
rs991573434 1754 dbSNP
rs1451589330 1763 dbSNP
rs1363151475 1766 dbSNP
rs999476047 1771 dbSNP
rs182052831 1773 dbSNP
rs750574519 1774 dbSNP
rs947143829 1776 dbSNP
rs41512547 1780 dbSNP
rs1203463732 1797 dbSNP
rs758536268 1803 dbSNP
rs1261770643 1812 dbSNP
rs568854883 1815 dbSNP
rs1246752777 1831 dbSNP
rs1300828132 1834 dbSNP
rs934910585 1837 dbSNP
rs1233170379 1838 dbSNP
rs529519962 1839 dbSNP
rs1325030663 1841 dbSNP
rs1380015399 1846 dbSNP
rs1384180775 1847 dbSNP
rs551297914 1848 dbSNP
rs1292087600 1854 dbSNP
rs1323472441 1856 dbSNP
rs955387696 1859 dbSNP
rs746492 1861 dbSNP
rs200688955 1863 dbSNP
rs755432048 1867 dbSNP
rs1180130738 1868 dbSNP
rs1379574322 1870 dbSNP
rs1018037980 1871 dbSNP
rs908516389 1872 dbSNP
rs186138215 1875 dbSNP
rs781570167 1881 dbSNP
rs1219374703 1884 dbSNP
rs192256035 1889 dbSNP
rs1280123681 1892 dbSNP
rs866521846 1893 dbSNP
rs1345354199 1905 dbSNP
rs566824961 1911 dbSNP
rs1404162318 1914 dbSNP
rs1224618775 1940 dbSNP
rs1325311960 1949 dbSNP
rs1026810705 1959 dbSNP
rs919804878 1974 dbSNP
rs1401809896 1980 dbSNP
rs1401496166 1981 dbSNP
rs937843865 1994 dbSNP
rs1312111779 2010 dbSNP
rs534316499 2026 dbSNP
rs982616201 2028 dbSNP
rs1035574269 2030 dbSNP
rs184040468 2031 dbSNP
rs1461562288 2032 dbSNP
rs1042071256 2040 dbSNP
rs1195899628 2041 dbSNP
rs370386700 2047 dbSNP
rs535314315 2053 dbSNP
rs1257420339 2056 dbSNP
rs570463527 2058 dbSNP
rs1444424745 2062 dbSNP
rs756987625 2063 dbSNP
rs1193667997 2064 dbSNP
rs188577829 2074 dbSNP
rs1288977159 2076 dbSNP
rs1318379891 2086 dbSNP
rs978516613 2087 dbSNP
rs912262083 2098 dbSNP
rs1292525973 2100 dbSNP
rs1448517684 2104 dbSNP
rs893330800 2105 dbSNP
rs924365789 2108 dbSNP
rs934795954 2110 dbSNP
rs1401301134 2117 dbSNP
rs374785441 2119 dbSNP
rs1459890665 2123 dbSNP
rs1255890706 2127 dbSNP
rs1417781600 2129 dbSNP
rs997004635 2131 dbSNP
rs1473991465 2134 dbSNP
rs1231567945 2140 dbSNP
rs1181530617 2148 dbSNP
rs1457086484 2150 dbSNP
rs1051893584 2153 dbSNP
rs1199986505 2156 dbSNP
rs1457069989 2181 dbSNP
rs890684227 2184 dbSNP
rs1187807384 2198 dbSNP
rs943639762 2206 dbSNP
rs1289084331 2212 dbSNP
rs1471489609 2216 dbSNP
rs541816244 2225 dbSNP
rs955460524 2225 dbSNP
rs1358346595 2226 dbSNP
rs1181793416 2238 dbSNP
rs1441195154 2245 dbSNP
rs1377948505 2246 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000292303.4 | 3UTR | CAAAGGGAGAGAGAGAGGUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000292303.4 | 3UTR | AAAGGGAGAGAGAGAGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000292303.4 | 3UTR | AAAGGGAGAGAGAGAGGUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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