pre-miRNA Information
pre-miRNA hsa-mir-4271   
Genomic Coordinates chr3: 49274120 - 49274186
Description Homo sapiens miR-4271 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4271
Sequence 39| GGGGGAAGAAAAGGUGGGG |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30481495 1 COSMIC
COSN31532060 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760829741 1 dbSNP
rs1277951968 2 dbSNP
rs189148716 3 dbSNP
rs757021935 4 dbSNP
rs1285201145 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol OSMR   
Synonyms IL-31R-beta, IL-31RB, OSMRB, PLCA1
Description oncostatin M receptor
Transcript NM_003999   
Other Transcripts NM_001168355   
Expression
Putative miRNA Targets on OSMR
3'UTR of OSMR
(miRNA target sites are highlighted)
>OSMR|NM_003999|3'UTR
   1 CCAGCATGCCGATTTCATACCTTATGCTACACAGACATTAAGAAGAGCAGAGCTGGCACCCTGTCATCACCAGTGGCCTT
  81 GGTCCTTAATCCCAGTACGATTTGCAGGTCTGGTTTATATAAGACCACTACAGTCTGGCTAGGTTAAAGGCCAGAGGCTA
 161 TGGAACTTAACACTCCCCATTGGAGCAAGCTTGCCCTAGAGACGGCAGGATCATGGGAGCATGCTTACCTTCTGCTGTTT
 241 GTTCCAGGCTCACCTTTAGAACAGGAGACTTGAGCTTGACCTAAGGATATGCATTAACCACTCTACAGACTCCCACTCAG
 321 TACTGTACAGGGTGGCTGTGGTCCTAGAAGTTCAGTTTTTACTGAGGAAATATTTCCATTAACAGCAATTATTATATTGA
 401 AGGCTTTAATAAAGGCCACAGGAGACATTACTATAGCATAGATTGTCAAATGTAAATTTACTGAGCGTGTTTTATAAAAA
 481 ACTCACAGGTGTTTGAGGCCAAAACAGATTTTAGACTTACCTTGAACGGATAAGAATCTATAGTTCACTGACACAGTAAA
 561 ATTAACTCTGTGGGTGGGGGCGGGGGGCATAGCTCTAATCTAATATATAAAATGTGTGATGAATCAACAAGATTTCCACA
 641 ATTCTTCTGTCAAGCTTACTACAGTGAAAGAATGGGATTGGCAAGTAACTTCTGACTTACTGTCAGTTGTACTTCTGCTC
 721 CATAGACATCAGTATTCTGCCATCATTTTTGATGACTACCTCAGAACATAAAAAGGAACGTATATCACATAATTCCAGTC
 801 ACAGTTTTTGGTTCCTCTTTTCTTTCAAGAACTATATATAAATGACCTGTTTTCACTTAGCATCCTTTGGACTCTGCAGT
 881 AGGTTGTCTGGGTCAAGATAACTCTCAGTCACATTTATATTCATATTATGCTAAAATAGTAAAATGAAACCTCATTGTTG
 961 GACATAATTTAGATATAACTAAAAAGTTCTATGAAGTGGGAAATTCCGTGTTGGCTCTGGAGCAGCTTTGTCTCCTCTGA
1041 ACCAATATATCCCAAACCAATATATGCAAAGCACCTGGTACACAACTGGTATTTTAGTACATGTTGGTTCTTTTGGTGCA
1121 ATCTCAGCTCACTGCAGCTTCCGCCTCCTAGATTCAAACAAACAGTTCTCCTGCCCCAGCCTCCAGAGCACCTAGGACTC
1201 CAGGTGCATGCTACCACACCTGACTAGTTTTTATATTTTTAGTAGAGATTGGGTTTTACCATATTGGCCAGGCTGGTCTC
1281 AAACTCCTGACCGCAGGTGATCCACCTGCCTCAGCTTCCCCAAGGGCTGGGATTACAGGTGTGAGCCACCATGCCCAGCC
1361 TATTTGTCACATTATTTGTCACATTTATTTTACTTTTATTTATTTTTTGAGATGAAATTTCGCTCTTGTTGCCCAGGCTG
1441 GAGTGCAATGGTGCAGCCTTGGCTCACTGCAACCTCCGCCTCCCAGGGTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGT
1521 AGCTGGGATTACAGGCATGCACCACCACACCCAGGTAATTTTGTATCTTTAGTAGAGATGGGGTTTCACCATGTTGGTCA
1601 GGCTGTTCTCGAACTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACT
1681 GCGCCTAGCCGTCACATTTCTAAACAAGCATGAAAGGGGTTCATTTTTGTCTTCTTCTTGCCTGCCGTCAGCATGGTGGA
1761 AATGGCTCTGCCTATGCTCATGCTTCTGGTGCCCAATGCCTTGCACTGTGCCATTCAACACTATGAAGAGAAACAAGTAG
1841 CCACACCTCAAAATAATGTGGCTGTCAACAACTGGCCTAAATAAACCTACACAAACCAGTACTTGCCTTTTGCTGGAAAC
1921 ATTGATTATGTGCTCCTCACGTAGTAGAAAGCGGTATCCTGATTAGTCTAACAGTTGTGTTAGACTTTAGGGCCAGTATT
2001 GTCAGCATTTATTTATTTATGTACCTTTGTTATGATGGGATATTTTTCATTTGAAACTTGTTCATAAAAATGTCAATGAC
2081 ATTGATGACTGATTTGTACATATTTTTCATATAGTTTTGTTTAAAAAATAATTCACGCAAAATCTTGAAGTCATTTTTGC
2161 TATTGAAATAAACCTTAATTAAAATATTTCATCATCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            |::|||   ||||||| 
Target 5' acCTGCCTCAGCTTCCCCa 3'
1304 - 1322 153.00 -22.80
2
miRNA  3' ggGGUGGAAA-AGAAGGGGg 5'
            :||::||| |||||::| 
Target 5' gtTCATTTTTGTCTTCTTCt 3'
1719 - 1738 133.00 -14.60
3
miRNA  3' gggGUGGAAAAGAAGGGGg 5'
             || :| | || |||| 
Target 5' aaaCAGTTCTCCTGCCCCa 3'
1160 - 1178 120.00 -11.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26987652 12 COSMIC
COSN31513352 19 COSMIC
COSN30499943 69 COSMIC
COSN20075329 106 COSMIC
COSN16616760 255 COSMIC
COSN2105160 440 COSMIC
COSN6296432 474 COSMIC
COSN20223050 534 COSMIC
COSN1315871 648 COSMIC
COSN28690949 855 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769825460 8 dbSNP
rs1341437066 9 dbSNP
rs1003033582 10 dbSNP
rs111889069 11 dbSNP
rs749514687 12 dbSNP
rs995085834 19 dbSNP
rs768960449 21 dbSNP
rs186349017 22 dbSNP
rs1426352714 24 dbSNP
rs1474460013 26 dbSNP
rs745476625 31 dbSNP
rs1012446289 38 dbSNP
rs950674645 40 dbSNP
rs1458083226 42 dbSNP
rs762212692 50 dbSNP
rs1382142430 51 dbSNP
rs1156728668 72 dbSNP
rs775575505 90 dbSNP
rs767424089 92 dbSNP
rs28364756 99 dbSNP
rs1051977 100 dbSNP
rs1026070883 102 dbSNP
rs955433311 106 dbSNP
rs1446499567 107 dbSNP
rs1282843059 108 dbSNP
rs550679979 121 dbSNP
rs911331499 123 dbSNP
rs1357545790 127 dbSNP
rs1293096220 130 dbSNP
rs921357582 130 dbSNP
rs1353186008 132 dbSNP
rs942511884 140 dbSNP
rs879115284 151 dbSNP
rs1259438347 160 dbSNP
rs989953837 162 dbSNP
rs914455201 163 dbSNP
rs1427801364 164 dbSNP
rs1193829093 168 dbSNP
rs1316179525 175 dbSNP
rs1374800776 177 dbSNP
rs552935803 178 dbSNP
rs115702064 179 dbSNP
rs1391299682 184 dbSNP
rs924767752 194 dbSNP
rs1164467162 197 dbSNP
rs1474067840 203 dbSNP
rs1239344 204 dbSNP
rs1194642863 206 dbSNP
rs1475156062 212 dbSNP
rs1240402091 214 dbSNP
rs1201039796 218 dbSNP
rs993063220 220 dbSNP
rs906855055 221 dbSNP
rs1212282402 229 dbSNP
rs938390020 242 dbSNP
rs1055934071 263 dbSNP
rs140757328 299 dbSNP
rs1214762437 301 dbSNP
rs1360787384 309 dbSNP
rs1044031851 313 dbSNP
rs548372381 317 dbSNP
rs1327665032 320 dbSNP
rs1459735656 322 dbSNP
rs1230977666 326 dbSNP
rs1012393960 329 dbSNP
rs1171710388 332 dbSNP
rs1017123836 338 dbSNP
rs1335032576 339 dbSNP
rs834011 341 dbSNP
rs1478394214 342 dbSNP
rs141516133 356 dbSNP
rs1192281451 374 dbSNP
rs1025921859 376 dbSNP
rs1485425112 381 dbSNP
rs190672964 384 dbSNP
rs756926856 387 dbSNP
rs1306571503 389 dbSNP
rs150863392 395 dbSNP
rs1018831227 407 dbSNP
rs1008245249 420 dbSNP
rs1302644557 423 dbSNP
rs1438588421 427 dbSNP
rs1378973955 434 dbSNP
rs778729828 435 dbSNP
rs1018744638 444 dbSNP
rs997257563 453 dbSNP
rs1415159363 455 dbSNP
rs1394524682 463 dbSNP
rs964103530 464 dbSNP
rs989901715 467 dbSNP
rs747340615 468 dbSNP
rs768904849 472 dbSNP
rs767751666 475 dbSNP
rs1418688079 476 dbSNP
rs1476274466 487 dbSNP
rs1157198981 499 dbSNP
rs978830129 503 dbSNP
rs967218425 528 dbSNP
rs1454685089 529 dbSNP
rs777118785 531 dbSNP
rs992965090 532 dbSNP
rs1245347103 535 dbSNP
rs748582024 542 dbSNP
rs537832784 553 dbSNP
rs948958124 566 dbSNP
rs1355558083 569 dbSNP
rs1234676764 570 dbSNP
rs1375019851 572 dbSNP
rs1311155263 576 dbSNP
rs1421515577 576 dbSNP
rs980213137 577 dbSNP
rs1304508459 582 dbSNP
rs1417758491 582 dbSNP
rs920265230 583 dbSNP
rs938324244 588 dbSNP
rs1047451532 590 dbSNP
rs1055479580 591 dbSNP
rs1208108067 603 dbSNP
rs886165573 604 dbSNP
rs139285755 606 dbSNP
rs915632303 609 dbSNP
rs1261292433 616 dbSNP
rs1214944815 618 dbSNP
rs1315013673 622 dbSNP
rs1262392030 624 dbSNP
rs556656151 628 dbSNP
rs1314635957 629 dbSNP
rs1037497608 631 dbSNP
rs1233611655 645 dbSNP
rs1355062017 667 dbSNP
rs574981215 671 dbSNP
rs898649788 685 dbSNP
rs1286725899 689 dbSNP
rs112205722 693 dbSNP
rs994368578 695 dbSNP
rs1385739258 700 dbSNP
rs1288840405 701 dbSNP
rs1047737293 709 dbSNP
rs891388739 711 dbSNP
rs76797509 716 dbSNP
rs1018278154 724 dbSNP
rs1461191376 727 dbSNP
rs1175685633 740 dbSNP
rs1407590677 741 dbSNP
rs554762238 750 dbSNP
rs1161681131 752 dbSNP
rs1261855475 761 dbSNP
rs573189802 765 dbSNP
rs1185379824 770 dbSNP
rs1484859292 777 dbSNP
rs964052509 780 dbSNP
rs540491852 781 dbSNP
rs1333867063 783 dbSNP
rs904507514 800 dbSNP
rs565011265 804 dbSNP
rs1021692881 811 dbSNP
rs1000175351 839 dbSNP
rs1031771001 847 dbSNP
rs1370371021 848 dbSNP
rs967165790 848 dbSNP
rs977301004 863 dbSNP
rs113447304 867 dbSNP
rs1392699950 870 dbSNP
rs1440707936 870 dbSNP
rs773235731 883 dbSNP
rs182864005 887 dbSNP
rs1024472980 899 dbSNP
rs959994088 905 dbSNP
rs529274827 906 dbSNP
rs1254872456 907 dbSNP
rs980366360 911 dbSNP
rs187503522 916 dbSNP
rs1250944398 923 dbSNP
rs991524613 925 dbSNP
rs1233464931 947 dbSNP
rs1281021828 952 dbSNP
rs1250905463 954 dbSNP
rs915579977 972 dbSNP
rs1350116498 976 dbSNP
rs1225424347 977 dbSNP
rs1202570023 987 dbSNP
rs1232405423 991 dbSNP
rs1481053738 992 dbSNP
rs1179184884 996 dbSNP
rs941713577 997 dbSNP
rs1333806402 998 dbSNP
rs1037435419 1000 dbSNP
rs983045129 1006 dbSNP
rs1297235674 1008 dbSNP
rs919026938 1009 dbSNP
rs1396334619 1012 dbSNP
rs1173675375 1017 dbSNP
rs1454162565 1027 dbSNP
rs763043301 1029 dbSNP
rs944458065 1045 dbSNP
rs1040645463 1047 dbSNP
rs543855737 1049 dbSNP
rs921776407 1050 dbSNP
rs1047233862 1052 dbSNP
rs1194276824 1064 dbSNP
rs149987785 1066 dbSNP
rs375120602 1075 dbSNP
rs1039966766 1078 dbSNP
rs899831840 1079 dbSNP
rs1011557171 1087 dbSNP
rs1213584414 1088 dbSNP
rs1335520751 1097 dbSNP
rs192991465 1098 dbSNP
rs903745655 1099 dbSNP
rs1000203057 1101 dbSNP
rs1053066719 1108 dbSNP
rs138837247 1111 dbSNP
rs1353424777 1120 dbSNP
rs1462114964 1124 dbSNP
rs1021642186 1143 dbSNP
rs891923479 1144 dbSNP
rs1470419133 1145 dbSNP
rs1014332162 1146 dbSNP
rs903290875 1149 dbSNP
rs1024922766 1152 dbSNP
rs1258408205 1155 dbSNP
rs970232006 1155 dbSNP
rs1439957304 1156 dbSNP
rs560281512 1164 dbSNP
rs1035532542 1169 dbSNP
rs146051707 1171 dbSNP
rs952258508 1172 dbSNP
rs1308156891 1178 dbSNP
rs1206885614 1181 dbSNP
rs532430040 1189 dbSNP
rs983118752 1193 dbSNP
rs1235467468 1207 dbSNP
rs766533967 1213 dbSNP
rs1022909437 1215 dbSNP
rs1468303349 1219 dbSNP
rs1352999968 1220 dbSNP
rs1194700813 1222 dbSNP
rs1255325031 1234 dbSNP
rs1384082403 1238 dbSNP
rs1156598055 1245 dbSNP
rs963014127 1246 dbSNP
rs1462811575 1252 dbSNP
rs369595386 1253 dbSNP
rs975840815 1254 dbSNP
rs973077564 1261 dbSNP
rs918974654 1262 dbSNP
rs1193933960 1265 dbSNP
rs1474687649 1275 dbSNP
rs1446949093 1291 dbSNP
rs182911527 1293 dbSNP
rs987665373 1294 dbSNP
rs1335894058 1298 dbSNP
rs912722723 1301 dbSNP
rs1273481569 1304 dbSNP
rs571043701 1313 dbSNP
rs878977322 1321 dbSNP
rs538282785 1322 dbSNP
rs1043914296 1323 dbSNP
rs187967413 1325 dbSNP
rs568577163 1331 dbSNP
rs1391884643 1340 dbSNP
rs1394903412 1341 dbSNP
rs1460623037 1344 dbSNP
rs1326278388 1350 dbSNP
rs1163888636 1351 dbSNP
rs935231610 1353 dbSNP
rs1351418341 1355 dbSNP
rs1000623280 1361 dbSNP
rs1053143384 1361 dbSNP
rs1269593013 1365 dbSNP
rs1196027420 1372 dbSNP
rs552942813 1372 dbSNP
rs947365984 1374 dbSNP
rs1220599507 1383 dbSNP
rs1252798979 1393 dbSNP
rs761860844 1394 dbSNP
rs750424948 1395 dbSNP
rs1274670868 1396 dbSNP
rs1045832874 1404 dbSNP
rs1295364978 1411 dbSNP
rs1236441590 1416 dbSNP
rs1043039735 1422 dbSNP
rs1275364767 1423 dbSNP
rs1433952036 1424 dbSNP
rs1027777362 1426 dbSNP
rs1329776905 1429 dbSNP
rs140013159 1440 dbSNP
rs1005080240 1441 dbSNP
rs998940339 1446 dbSNP
rs1175556351 1448 dbSNP
rs112368307 1449 dbSNP
rs759871525 1463 dbSNP
rs1192224021 1469 dbSNP
rs767205911 1478 dbSNP
rs752583898 1479 dbSNP
rs1204736604 1486 dbSNP
rs1485889936 1488 dbSNP
rs1271884904 1493 dbSNP
rs1022866909 1497 dbSNP
rs965759673 1502 dbSNP
rs1348514478 1506 dbSNP
rs1302585037 1507 dbSNP
rs963295468 1510 dbSNP
rs554825320 1516 dbSNP
rs973032031 1535 dbSNP
rs1217325498 1548 dbSNP
rs1375228294 1549 dbSNP
rs1025978667 1551 dbSNP
rs950475120 1552 dbSNP
rs357252 1556 dbSNP
rs376818089 1558 dbSNP
rs1421288279 1564 dbSNP
rs373328070 1565 dbSNP
rs541742835 1565 dbSNP
rs766803531 1565 dbSNP
rs1469324249 1566 dbSNP
rs1249084585 1580 dbSNP
rs944191158 1612 dbSNP
rs1398796344 1614 dbSNP
rs1317531960 1617 dbSNP
rs764154142 1626 dbSNP
rs1279582731 1630 dbSNP
rs168567 1640 dbSNP
rs1318612399 1641 dbSNP
rs1284723488 1647 dbSNP
rs1160535420 1651 dbSNP
rs1222926142 1651 dbSNP
rs1348935158 1652 dbSNP
rs921476519 1661 dbSNP
rs756840973 1683 dbSNP
rs778639835 1684 dbSNP
rs558853565 1691 dbSNP
rs950092982 1692 dbSNP
rs1051942 1699 dbSNP
rs934679465 1700 dbSNP
rs905987023 1702 dbSNP
rs1057191122 1719 dbSNP
rs937415061 1724 dbSNP
rs1049249326 1730 dbSNP
rs887929365 1731 dbSNP
rs148889745 1733 dbSNP
rs142592579 1734 dbSNP
rs1179562235 1737 dbSNP
rs1489528439 1738 dbSNP
rs1044259423 1740 dbSNP
rs902062079 1745 dbSNP
rs1254687631 1747 dbSNP
rs574210824 1748 dbSNP
rs1234160444 1756 dbSNP
rs879374636 1759 dbSNP
rs1026673252 1760 dbSNP
rs1029071748 1777 dbSNP
rs1238895006 1784 dbSNP
rs1383930747 1786 dbSNP
rs1363357746 1788 dbSNP
rs1288787423 1797 dbSNP
rs1433416874 1800 dbSNP
rs1397102664 1809 dbSNP
rs1468384039 1819 dbSNP
rs541498595 1819 dbSNP
rs1461661533 1820 dbSNP
rs1157742865 1831 dbSNP
rs1408473757 1850 dbSNP
rs200342008 1851 dbSNP
rs1420198026 1864 dbSNP
rs199839159 1864 dbSNP
rs953188470 1864 dbSNP
rs10592151 1866 dbSNP
rs1463453782 1866 dbSNP
rs16351 1866 dbSNP
rs1032199580 1868 dbSNP
rs956542805 1869 dbSNP
rs201287518 1870 dbSNP
rs950400321 1882 dbSNP
rs1229784825 1887 dbSNP
rs1308133893 1891 dbSNP
rs1295554658 1897 dbSNP
rs1226881838 1900 dbSNP
rs1336364906 1906 dbSNP
rs1327013343 1915 dbSNP
rs1334162551 1915 dbSNP
rs1389637406 1918 dbSNP
rs1291407772 1920 dbSNP
rs1463105123 1921 dbSNP
rs531816170 1921 dbSNP
rs1441777890 1923 dbSNP
rs1447594399 1926 dbSNP
rs764254237 1933 dbSNP
rs1008992178 1941 dbSNP
rs376362416 1942 dbSNP
rs1356299300 1944 dbSNP
rs1432375383 1948 dbSNP
rs748578913 1951 dbSNP
rs1197745175 1953 dbSNP
rs73751812 1954 dbSNP
rs1203043007 1960 dbSNP
rs981499536 1966 dbSNP
rs34747631 1970 dbSNP
rs192205678 1973 dbSNP
rs1396698833 1974 dbSNP
rs1306875887 1975 dbSNP
rs1200576442 1978 dbSNP
rs377072612 1989 dbSNP
rs1377265230 1991 dbSNP
rs976069931 1992 dbSNP
rs140757977 1994 dbSNP
rs1435669450 1996 dbSNP
rs937466784 1997 dbSNP
rs1251276033 1998 dbSNP
rs1180195376 2006 dbSNP
rs1049154337 2007 dbSNP
rs564802177 2007 dbSNP
rs887836063 2007 dbSNP
rs940872659 2016 dbSNP
rs968895977 2022 dbSNP
rs145787865 2025 dbSNP
rs1240121201 2027 dbSNP
rs1441372205 2039 dbSNP
rs1336049045 2041 dbSNP
rs1287311589 2058 dbSNP
rs1407510599 2063 dbSNP
rs751421267 2065 dbSNP
rs1394443136 2073 dbSNP
rs924883577 2077 dbSNP
rs998167244 2080 dbSNP
rs542518266 2086 dbSNP
rs1160093547 2095 dbSNP
rs1028685335 2097 dbSNP
rs1411564913 2100 dbSNP
rs934658172 2101 dbSNP
rs1476285156 2102 dbSNP
rs1057442909 2110 dbSNP
rs1394436259 2113 dbSNP
rs1441196974 2114 dbSNP
rs770745452 2114 dbSNP
rs917307409 2120 dbSNP
rs1328884378 2127 dbSNP
rs766228210 2129 dbSNP
rs7318 2137 dbSNP
rs956408260 2138 dbSNP
rs1293392515 2147 dbSNP
rs1446567701 2148 dbSNP
rs1044540046 2161 dbSNP
rs898981473 2169 dbSNP
rs1439225602 2170 dbSNP
rs1025221135 2173 dbSNP
rs1382608559 2174 dbSNP
rs1303276670 2175 dbSNP
rs1372314247 2180 dbSNP
rs1387670565 2185 dbSNP
rs773724744 2190 dbSNP
rs994701745 2193 dbSNP
rs1318236705 2194 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_003999 | 3UTR | AAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_003999 | 3UTR | AUUCAAACAAACAGUUCUCCUGCCCCAGCCUCCAGAGCACCUAGGACUCCAGGUGCAUGCUACCACACCUGACUAGUUUUUAUAUUUUUAGUAGAGAUUGGGUUUUACCAUAUUGGCCAGGCUGGUCUCAAACUCCUGACCGCAGGUGAUCCACCUGCCUCAGCUUCCCCAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_003999 | 3UTR | CUCCUGCCCCAGCCUCCAGAGCACCUAGGACUCCAGGUGCAUGCUACCACACCUGACUAGUUUUUAUAUUUUUAGUAGAGAUUGGGUUUUACCAUAUUGGCCAGGCUGGUCUCAAACUCCUGACCGCAGGUGAUCCACCUGCCUCAGCUUCCCCAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003999 | 3UTR | AGAGCACCUAGGACUCCAGGUGCAUGCUACCACACCUGACUAGUUUUUAUAUUUUUAGUAGAGAUUGGGUUUUACCAUAUUGGCCAGGCUGGUCUCAAACUCCUGACCGCAGGUGAUCCACCUGCCUCAGCUUCCCCAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_003999 | 3UTR | UCCUGCCCCAGCCUCCAGAGCACCUAGGACUCCAGGUGCAUGCUACCACACCUGACUAGUUUUUAUAUUUUUAGUAGAGAUUGGGUUUUACCAUAUUGGCCAGGCUGGUCUCAAACUCCUGACCGCAGGUGAUCCACCUGCCUCAGCUUCCCCAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_003999 | 3UTR | GCCCCAGCCUCCAGAGCACCUAGGACUCCAGGUGCAUGCUACCACACCUGACUAGUUUUUAUAUUUUUAGUAGAGAUUGGGUUUUACCAUAUUGGCCAGGCUGGUCUCAAACUCCUGACCGCAGGUGAUCCACCUGCCUCAGCUUCCCCAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_003999 | 3UTR | AGCCUCCAGAGCACCUAGGACUCCAGGUGCAUGCUACCACACCUGACUAGUUUUUAUAUUUUUAGUAGAGAUUGGGUUUUACCAUAUUGGCCAGGCUGGUCUCAAACUCCUGACCGCAGGUGAUCCACCUGCCUCAGCUUCCCCAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUACAGGUGUGAGCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUACAGGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000274276.3 | 3UTR | CAAGGGCUGGGAUUACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
181 hsa-miR-4271 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066209 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079367 CCDC137 coiled-coil domain containing 137 2 2
MIRT081183 MIDN midnolin 2 4
MIRT083278 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT086207 HOXD13 homeobox D13 2 2
MIRT133713 SKI SKI proto-oncogene 2 4
MIRT150653 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159166 NRBP1 nuclear receptor binding protein 1 2 2
MIRT160059 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180856 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT181931 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT190628 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190654 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196107 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT263248 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT321168 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT338624 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT366301 GDI1 GDP dissociation inhibitor 1 2 4
MIRT375172 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT441488 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT442333 WNT9B Wnt family member 9B 2 2
MIRT443889 CNKSR3 CNKSR family member 3 2 2
MIRT445880 WBP1L WW domain binding protein 1 like 2 2
MIRT449312 MRO maestro 2 2
MIRT449844 BCL2L13 BCL2 like 13 2 2
MIRT450304 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450515 EMX1 empty spiracles homeobox 1 2 2
MIRT451243 ZNF444 zinc finger protein 444 2 2
MIRT451713 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451792 TLR5 toll like receptor 5 2 2
MIRT451823 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT451906 ILK integrin linked kinase 2 2
MIRT452181 KIAA1456 KIAA1456 2 4
MIRT452242 TRAM1 translocation associated membrane protein 1 2 2
MIRT452544 ZNF467 zinc finger protein 467 2 2
MIRT452605 REPIN1 replication initiator 1 2 2
MIRT454505 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454657 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT455354 KDM5C lysine demethylase 5C 2 2
MIRT455452 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455587 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT456501 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456815 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457425 NOL10 nucleolar protein 10 2 2
MIRT457468 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457660 SERINC1 serine incorporator 1 2 2
MIRT458231 NXPH3 neurexophilin 3 2 2
MIRT458374 ITM2C integral membrane protein 2C 2 2
MIRT458667 GPR35 G protein-coupled receptor 35 2 2
MIRT459665 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459825 TPP1 tripeptidyl peptidase 1 2 2
MIRT460564 FEM1A fem-1 homolog A 2 2
MIRT460725 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT461121 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461529 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461750 DDX11 DEAD/H-box helicase 11 2 2
MIRT462570 STS steroid sulfatase 2 2
MIRT462798 NTN1 netrin 1 2 2
MIRT463030 ZNF689 zinc finger protein 689 2 2
MIRT463991 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464684 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465439 TP53 tumor protein p53 2 2
MIRT465512 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465649 TNPO2 transportin 2 2 10
MIRT465947 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466028 TMEM189 transmembrane protein 189 2 2
MIRT468076 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT468131 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468498 SESN2 sestrin 2 2 2
MIRT468879 RREB1 ras responsive element binding protein 1 2 2
MIRT469318 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469558 RARA retinoic acid receptor alpha 2 2
MIRT469793 RAB15 RAB15, member RAS oncogene family 2 2
MIRT469896 PTRF caveolae associated protein 1 2 2
MIRT470235 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470808 PLXND1 plexin D1 2 2
MIRT471597 PAQR5 progestin and adipoQ receptor family member 5 2 10
MIRT471710 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT471752 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT472978 MRRF mitochondrial ribosome recycling factor 2 2
MIRT473538 MAX MYC associated factor X 2 2
MIRT473581 MAT2A methionine adenosyltransferase 2A 2 2
MIRT473970 LRRC58 leucine rich repeat containing 58 2 2
MIRT474223 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474553 KLHDC3 kelch domain containing 3 2 2
MIRT474777 KIAA0895L KIAA0895 like 2 2
MIRT476042 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476438 GBA2 glucosylceramidase beta 2 2 2
MIRT477773 E2F3 E2F transcription factor 3 2 4
MIRT477946 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478782 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479320 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT480405 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480593 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT480963 BBC3 BCL2 binding component 3 2 2
MIRT481127 AZIN1 antizyme inhibitor 1 2 4
MIRT481444 ARRB2 arrestin beta 2 2 2
MIRT481687 AR androgen receptor 2 2
MIRT481730 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT482386 AEN apoptosis enhancing nuclease 2 2
MIRT482564 ABHD2 abhydrolase domain containing 2 2 2
MIRT482605 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483256 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483531 TAGLN2 transgelin 2 2 2
MIRT483840 UNC5B unc-5 netrin receptor B 2 4
MIRT483935 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484414 SNX19 sorting nexin 19 2 2
MIRT484487 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484609 SIX3 SIX homeobox 3 2 6
MIRT484703 RNF11 ring finger protein 11 2 2
MIRT485244 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT485607 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT485965 RTBDN retbindin 2 2
MIRT487308 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487329 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487410 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487607 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487689 CDK14 cyclin dependent kinase 14 2 2
MIRT487787 GPR20 G protein-coupled receptor 20 2 4
MIRT488026 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT488476 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT488761 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489161 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489529 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT489774 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT489878 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT490094 FN3K fructosamine 3 kinase 2 2
MIRT490202 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490283 ISL2 ISL LIM homeobox 2 2 2
MIRT490377 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491035 ALPK3 alpha kinase 3 2 2
MIRT491186 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491766 ZNF385A zinc finger protein 385A 2 2
MIRT491888 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491981 UNK unkempt family zinc finger 2 2
MIRT492400 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT493647 HDLBP high density lipoprotein binding protein 2 2
MIRT494010 DUSP9 dual specificity phosphatase 9 2 2
MIRT494167 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT495712 PADI1 peptidyl arginine deiminase 1 2 2
MIRT496873 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT499175 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT501652 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT506645 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510590 TUBB2A tubulin beta 2A class IIa 2 6
MIRT511907 FKBP1A FK506 binding protein 1A 2 2
MIRT513063 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513104 DYNAP dynactin associated protein 2 2
MIRT521804 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT523520 GLUL glutamate-ammonia ligase 2 2
MIRT525085 FRK fyn related Src family tyrosine kinase 2 2
MIRT530930 SCIN scinderin 2 2
MIRT533501 TRIM71 tripartite motif containing 71 2 2
MIRT538560 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT544556 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT555912 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT560405 TMEM69 transmembrane protein 69 2 2
MIRT560664 RTN3 reticulon 3 2 2
MIRT564061 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT565504 SP1 Sp1 transcription factor 2 2
MIRT570014 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572321 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573229 TRIM21 tripartite motif containing 21 2 2
MIRT573487 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574137 MARVELD1 MARVEL domain containing 1 2 2
MIRT574323 ZNF703 zinc finger protein 703 2 2
MIRT620939 OSMR oncostatin M receptor 2 2
MIRT650080 MTL5 testis expressed metallothionein like protein 2 2
MIRT684553 ZNF708 zinc finger protein 708 2 2
MIRT685841 ANGEL1 angel homolog 1 2 2
MIRT688551 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT701985 MIER3 MIER family member 3 2 2
MIRT703899 EPT1 selenoprotein I 2 2
MIRT706388 MC2R melanocortin 2 receptor 2 2
MIRT707487 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711885 INSIG2 insulin induced gene 2 2 2
MIRT719164 KIF6 kinesin family member 6 2 2
MIRT721294 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT721775 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT723763 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725485 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4271 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-4271 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4271 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-4271 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4271 Anlotinib 25017411 NSC832523 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Icotinib 22024915 NSC800770 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Erlotinib 176870 NSC718781 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-4271 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4271 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4271 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4271 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4271 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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