pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol CLSTN3   
Synonyms CDHR14, CSTN3, alcbeta
Description calsyntenin 3
Transcript NM_014718   
Expression
Putative miRNA Targets on CLSTN3
3'UTR of CLSTN3
(miRNA target sites are highlighted)
>CLSTN3|NM_014718|3'UTR
   1 GGCCTACACCTCTCCCCACGCAGAGGGGGAATTCTGCCCTGGTGAAACAGACACTCCAGACATGGGAGAAGGACTTTCTG
  81 GGAACACAGAGACCAAGAGGGAGAGAGGCTTCAGAACCAGTCCTCCTTTCATTTCAAAACCCCAGCGGGCCCTCTGGAGT
 161 CCGCCCTGCCCCTCCCCCGGCCCCCCATCCCTCACTTCTGGGCTGTCATGCTCCTGGTGTGCCCCTTGCACTGGGGCTGG
 241 CTGGGTTGGAAAGTGGGCTGGACTTCAGCTGCCTTTCTACCCCCAATGGCAGCTGCCCCCTTAGCACTCACTGTGTTGGG
 321 GAGAGGGTGACGATTGCAATGGCTGGGGCTGGGGCTGGGGGTGGGATTGAAGGAAACCCTCTCCTCTCCCCTTCCCTTCT
 401 CTCTCCTGTCCATGGGAAGCTTTTCCCCCTCTGCAGGGCTCCCTCAGCTGGACCATCGTCCCTGCTTCTCTTATGATCGC
 481 CCCACCTCATTTCCATTTCAGTCTGGGGACCCCATTTCTCCCTCCTTTCCAACTTCCTTCCTTTCTTGTCCTGTTTCCCT
 561 TCCTGCCCTTGCAGTCCTGAGGTCCTGCAGCCCCGGCCCCTCCTCCGTGACCTGGTGTGGCCAGGCTGCGGGGACGGGAG
 641 GGGACGTGGGGGCCCCGGGTGTACATATATAATGTATATTTTTTCAATGTTGTCGTGAGTGCAGCCCATGTTCCTGCGTG
 721 CAGCTCACGGCCTTGTGTGTATGTGTGTGTGTGTGTGTGTGTGAGGCATCGTCATGTCCTGGGGCAGGGGCGGGGGGTTG
 801 GGTGTGGTGAGGGAGGGGACATATCCTAGGGTTTTCAAATAAAACAATCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auGCG-GUC-AGUUAUGGAACACu 5'
            ||: ||| |||  :||||||| 
Target 5' tgCGTGCAGCTCACGGCCTTGTGt 3'
715 - 738 160.00 -20.20
2
miRNA  3' augCGGUCAGUUAU--GGAACACu 5'
             | | ||| ||:  ||| ||| 
Target 5' ctgGGCTGTC-ATGCTCCTGGTGt 3'
198 - 220 120.00 -13.50
3
miRNA  3' auGCGGUCAGUUA-UGGAACACu 5'
            | |:  || :| |||| ||| 
Target 5' gcCCCTCCTCCGTGACCTGGTGt 3'
596 - 618 120.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28873912 21 COSMIC
COSN1151782 38 COSMIC
COSN28198278 44 COSMIC
COSN31516607 69 COSMIC
COSN31482258 113 COSMIC
COSN19727019 148 COSMIC
COSN1151783 362 COSMIC
COSN25164459 476 COSMIC
COSN1151785 531 COSMIC
COSN25754466 804 COSMIC
COSN6537231 837 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1183467310 4 dbSNP
rs780563104 4 dbSNP
rs752170176 6 dbSNP
rs1356904354 10 dbSNP
rs772195799 11 dbSNP
rs1302763081 15 dbSNP
rs1172787379 17 dbSNP
rs751169860 20 dbSNP
rs1023862335 21 dbSNP
rs1417167692 22 dbSNP
rs1286782968 24 dbSNP
rs760882672 27 dbSNP
rs962965550 28 dbSNP
rs1224503000 30 dbSNP
rs901665206 31 dbSNP
rs200459589 32 dbSNP
rs1209574114 35 dbSNP
rs1280947222 38 dbSNP
rs1486571839 39 dbSNP
rs1179956484 40 dbSNP
rs1250751208 49 dbSNP
rs372811449 50 dbSNP
rs1178554725 53 dbSNP
rs1278158701 54 dbSNP
rs1377979143 66 dbSNP
rs1330737336 75 dbSNP
rs1310708160 78 dbSNP
rs986933673 84 dbSNP
rs957553805 89 dbSNP
rs61917953 92 dbSNP
rs80341359 98 dbSNP
rs761614283 99 dbSNP
rs776787505 103 dbSNP
rs1412062763 108 dbSNP
rs1160893026 117 dbSNP
rs1019971720 124 dbSNP
rs1379348594 125 dbSNP
rs750677929 126 dbSNP
rs1176417714 128 dbSNP
rs981208597 129 dbSNP
rs757082280 132 dbSNP
rs928394726 137 dbSNP
rs958890260 147 dbSNP
rs1236321179 151 dbSNP
rs1286052016 155 dbSNP
rs765483922 163 dbSNP
rs920188138 177 dbSNP
rs775619361 179 dbSNP
rs1047030119 180 dbSNP
rs1275578255 182 dbSNP
rs935058858 183 dbSNP
rs1436379030 185 dbSNP
rs1348684421 202 dbSNP
rs908567785 204 dbSNP
rs1420635620 206 dbSNP
rs944064772 209 dbSNP
rs1360324776 219 dbSNP
rs1172969084 220 dbSNP
rs1156384186 225 dbSNP
rs896239286 226 dbSNP
rs1041095512 232 dbSNP
rs753924152 246 dbSNP
rs1465435403 251 dbSNP
rs996019131 254 dbSNP
rs1194342738 262 dbSNP
rs1373891097 274 dbSNP
rs1283644312 277 dbSNP
rs1437244771 277 dbSNP
rs1314235449 278 dbSNP
rs1279382603 284 dbSNP
rs1050686540 287 dbSNP
rs1365604415 288 dbSNP
rs1280603982 291 dbSNP
rs969168280 294 dbSNP
rs893018259 297 dbSNP
rs1011922986 302 dbSNP
rs1365742173 303 dbSNP
rs1019940631 311 dbSNP
rs1426817481 316 dbSNP
rs1258957858 327 dbSNP
rs1296796499 329 dbSNP
rs967018140 332 dbSNP
rs1318290112 333 dbSNP
rs1174943332 337 dbSNP
rs141967428 341 dbSNP
rs3837528 341 dbSNP
rs763226635 341 dbSNP
rs767245153 341 dbSNP
rs1183417445 346 dbSNP
rs71783469 347 dbSNP
rs1197807145 356 dbSNP
rs1238214279 359 dbSNP
rs868018554 362 dbSNP
rs898748076 367 dbSNP
rs1355484934 371 dbSNP
rs1002570918 391 dbSNP
rs1219766799 395 dbSNP
rs1317903438 398 dbSNP
rs1276676981 400 dbSNP
rs1035431513 402 dbSNP
rs1380388981 408 dbSNP
rs1301832082 414 dbSNP
rs373798355 415 dbSNP
rs1025805207 420 dbSNP
rs1170856480 424 dbSNP
rs991632596 426 dbSNP
rs1465011958 427 dbSNP
rs1421447538 429 dbSNP
rs920097018 430 dbSNP
rs1166855105 434 dbSNP
rs1412806888 436 dbSNP
rs951502481 442 dbSNP
rs952969857 443 dbSNP
rs1008825156 455 dbSNP
rs1019660821 456 dbSNP
rs982976365 458 dbSNP
rs12303975 459 dbSNP
rs1476762425 476 dbSNP
rs111605968 479 dbSNP
rs944032130 480 dbSNP
rs1247633247 484 dbSNP
rs1477671798 488 dbSNP
rs1322640969 493 dbSNP
rs1041062550 509 dbSNP
rs921317012 522 dbSNP
rs1226257320 527 dbSNP
rs1393512014 557 dbSNP
rs979339085 558 dbSNP
rs1331407630 559 dbSNP
rs1445336207 560 dbSNP
rs1323496776 565 dbSNP
rs181907162 572 dbSNP
rs1433022143 574 dbSNP
rs935152318 585 dbSNP
rs992410458 586 dbSNP
rs1367663305 587 dbSNP
rs1162507492 593 dbSNP
rs187377937 595 dbSNP
rs754643283 596 dbSNP
rs376972753 598 dbSNP
rs947266090 607 dbSNP
rs879191570 608 dbSNP
rs1041645326 618 dbSNP
rs1265196847 626 dbSNP
rs1220786927 630 dbSNP
rs1356317609 631 dbSNP
rs903136611 636 dbSNP
rs1002538344 637 dbSNP
rs1228755515 638 dbSNP
rs1373934597 646 dbSNP
rs1047316736 647 dbSNP
rs779598147 652 dbSNP
rs1389974064 655 dbSNP
rs1291739690 657 dbSNP
rs7977239 658 dbSNP
rs894191346 660 dbSNP
rs1013098615 665 dbSNP
rs1026757857 667 dbSNP
rs1419394412 681 dbSNP
rs1487796498 684 dbSNP
rs1191941111 688 dbSNP
rs1370506708 692 dbSNP
rs768585183 695 dbSNP
rs1267211511 696 dbSNP
rs756008922 704 dbSNP
rs1163142384 705 dbSNP
rs1287202699 707 dbSNP
rs1215425447 709 dbSNP
rs1020239842 710 dbSNP
rs1412287286 713 dbSNP
rs952977526 719 dbSNP
rs1330035938 725 dbSNP
rs1281230163 726 dbSNP
rs1401781292 727 dbSNP
rs746944670 730 dbSNP
rs761559167 735 dbSNP
rs1297428749 736 dbSNP
rs899904811 738 dbSNP
rs1298929059 740 dbSNP
rs1174561640 742 dbSNP
rs1264342158 742 dbSNP
rs1377142191 742 dbSNP
rs398018300 742 dbSNP
rs55888711 742 dbSNP
rs71745789 742 dbSNP
rs760634374 742 dbSNP
rs767285713 742 dbSNP
rs1193444121 744 dbSNP
rs1444900582 748 dbSNP
rs1257785826 750 dbSNP
rs997366119 755 dbSNP
rs1360131277 759 dbSNP
rs1398451067 761 dbSNP
rs1343601324 765 dbSNP
rs779930796 768 dbSNP
rs1260771482 771 dbSNP
rs1220390804 772 dbSNP
rs1318573502 779 dbSNP
rs1277313796 781 dbSNP
rs1315027808 786 dbSNP
rs1428330908 786 dbSNP
rs1341975738 787 dbSNP
rs1336323260 792 dbSNP
rs531674948 793 dbSNP
rs1283477541 797 dbSNP
rs925087551 799 dbSNP
rs1241677196 800 dbSNP
rs1474593618 802 dbSNP
rs1286180435 803 dbSNP
rs1352350036 804 dbSNP
rs1213917302 806 dbSNP
rs760874328 807 dbSNP
rs968668795 808 dbSNP
rs1187339988 809 dbSNP
rs1236195274 811 dbSNP
rs1442163216 815 dbSNP
rs1257306680 825 dbSNP
rs1457844130 825 dbSNP
rs1801869 832 dbSNP
rs1030843338 841 dbSNP
rs956838487 842 dbSNP
rs992004042 845 dbSNP
rs1417946035 846 dbSNP
rs1174496036 849 dbSNP
rs1403210178 850 dbSNP
rs1396370902 851 dbSNP
rs1273361961 852 dbSNP
rs1408777410 852 dbSNP
rs1472249601 852 dbSNP
rs753888833 860 dbSNP
rs558432390 861 dbSNP
rs79921532 864 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' augcggucaguuaUGGAACACu 5'
                       :||||||| 
Target 5' -------------GCCUUGUGu 3'
1 - 9
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_014718 | 3UTR | GGGGCCCCGGGUGUACAUAUAUAAUGUAUAUUUUUUCAAUGUUGUCGUGAGUGCAGCCCAUGUUCCUGCGUGCAGCUCACGGCCUUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_014718 | 3UTR | UAUAUUUUUUCAAUGUUGUCGUGAGUGCAGCCCAUGUUCCUGCGUGCAGCUCACGGCCUUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_014718 | 3UTR | AUAUAUAAUGUAUAUUUUUUCAAUGUUGUCGUGAGUGCAGCCCAUGUUCCUGCGUGCAGCUCACGGCCUUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_014718 | 3UTR | UAAUGUAUAUUUUUUCAAUGUUGUCGUGAGUGCAGCCCAUGUUCCUGCGUGCAGCUCACGGCCUUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_014718 | 3UTR | AGCCCAUGUUCCUGCGUGCAGCUCACGGCCUUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_014718 | 3UTR | ACAUAUAUAAUGUAUAUUUUUUCAAUGUUGUCGUGAGUGCAGCCCAUGUUCCUGCGUGCAGCUCACGGCCUUGUGUGUAUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000266546.6 | 3UTR | GCCUUGUGUGUAUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000266546.6 | 3UTR | GCCUUGUGUGUAUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000266546.6 | 3UTR | UUGUGUGUAUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000266546.6 | 3UTR | CACGGCCUUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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