miRTarBase - #MIRT621358


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pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GUCA1B   
Synonyms GCAP2, GUCA2, RP48
Description guanylate cyclase activator 1B
Transcript NM_002098   
Expression
Putative miRNA Targets on GUCA1B
3'UTR of GUCA1B
(miRNA target sites are highlighted)		 
>GUCA1B|NM_002098|3'UTR
   1 GGAGTCTGGGGCCCCTCCACGACTCCAGGCTCACCCAGGTTTCCAGGGTAGTAGGAGGGTCCCTGGCTCAGCCTGCTCAT
  81 GCCCACTCTTCCCCTGGTGTTGACTTCCTGGCACCCCCTGTGCAGGGCTGAGTGGGGATGGGGAAGGGCTGCTGGGTTTG
 161 AAGTGGCCAACAGGGCATAGTCCATTTTGGAGGAGTCCCTGGGATGGTGAAGGGAATTCAGTTACTTTTCCTGTTCAGCC
 241 GCTCCTGGGAGGACTGTGCCTTGGCTGGGTGGTTGTGGGGCTCCCACAGTTTCTGGGTGTTCTCAGTTGGAAGCAAGAGC
 321 CAACTGAGGGGTGAGGGTCCCACAGACCAAATCAGAAATGAGAACACAAAGACTGGTAGGAGGCAGGGGTGGGAGGGTGT
 401 TGAGACTGAAGAAAAGGCAGGAGTTGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGG
 481 CAGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATC
 561 AGCCGGGTGAGGTGGCGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAGAGAATGGCGTGAACCCCAGGGGGC
 641 CGAGCCTACAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGACGACAGTGAGACTCCGTCTCAAAAAAAAAAAAAG
 721 AAAGAAAAGAAAAGGCAGGAGTTTTGGGGGGCAGGGGGCAGCAATAATTCTATAACTTCCGGGATGCTGAGGGGCGTTCA
 801 TGGGGAGGACCCTGGCCTCCTCCTCCCCAAGGCATCCTCACCAGTGGTGTCAACAGGAAAAATGGCAGCAAATACGCTGC
 881 AGGCTGTGGTCTTTCTGCCTTTGAAAGGGTCAGCTGTACTTAAAGGGACTGTTTCAGCTCTGCCTGGGTGCTGCTCTGGG
 961 ACCCCCTGCTGCCAACCCACCACTCCCCCAACAATCCTCTCTTTCCATCCATATCCCCCAGTATGGACCTTCCACAACTC
1041 CCAGCCATAAGCTGAATGTTTCTCTTTAAAGGATGGAGAAAACTTCTGTCTGTCTCTGGCAAGAATTGGGGGACTGTTGA
1121 CTGGGATTGTGGGCTGGGCTTGGCTTCTAACTGCTGTGTGACCCAAGACAGCCACTTCTCCTCCCTAACCTTGGTTATGT
1201 CTTGGCAGCACAGTGAGCAGGTCGGACTAGGCGAACAGTTTTGGATTATTGTGTTTTTAGATGTGGAATTATTTTTTGTT
1281 ATATAAACTCTTATGTGTAACCCCAATATAGAAACTAGATTAAAAGGGAGTCTCTCTGGTTGAAAGGGGAGCTGAGTACC
1361 CTCTGGAACTGGAGGCACCTCTGAAAAAAGCAAACTGAAAACCAGTGCCCTGGGTCACTGTTACTCCTATAAGACAGTTT
1441 AAAGTGAGACCTGGAAAAACATTTGCTTTACCTTGAATAGATAGGTTTTTATGTTGGTATATAAGAAATAAAACTAACCT
1521 ATTAAACCTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            :|::| ||||||||||||  
Target 5' ggGGTGAAACCCCGTCTCTAct 3'
 523 - 544 160.00 -25.10
2 
miRNA  3' ucUCGUUCUGGGGCAGAGAUUu 5'
            ||::||||:||||||| || 
Target 5' acAGTGAGACTCCGTCTCAAAa 3'
 689 - 710 156.00 -24.80
3 
miRNA  3' ucUCG--UUCUGGGGCAGAGAUUu 5'
            |||  || ::::| |||:||| 
Target 5' taAGCTGAATGTTTC-TCTTTAAa 3'
 1048 - 1070 137.00 -8.43
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
356732 95 ClinVar
910193 107 ClinVar
356731 179 ClinVar
356730 205 ClinVar
356729 220 ClinVar
356728 221 ClinVar
356727 295 ClinVar
910192 358 ClinVar
910191 362 ClinVar
908243 428 ClinVar
356726 429 ClinVar
356725 433 ClinVar
908242 445 ClinVar
356724 451 ClinVar
356723 457 ClinVar
908241 461 ClinVar
356722 473 ClinVar
356721 477 ClinVar
356720 480 ClinVar
356719 488 ClinVar
356718 502 ClinVar
356717 503 ClinVar
356716 507 ClinVar
912246 559 ClinVar
356715 581 ClinVar
911016 589 ClinVar
356714 618 ClinVar
356713 666 ClinVar
911015 688 ClinVar
356712 767 ClinVar
356711 780 ClinVar
356710 832 ClinVar
356709 868 ClinVar
356708 928 ClinVar
910125 940 ClinVar
356707 961 ClinVar
356706 997 ClinVar
356705 1018 ClinVar
356704 1088 ClinVar
356703 1126 ClinVar
356702 1203 ClinVar
356701 1263 ClinVar
356700 1318 ClinVar
COSN31785568 11 COSMIC
COSN30476149 13 COSMIC
COSN30478341 36 COSMIC
COSN30192875 40 COSMIC
COSN31508249 46 COSMIC
COSN30151259 49 COSMIC
COSN30162785 55 COSMIC
COSN31578882 57 COSMIC
COSN24383933 67 COSMIC
COSN2382704 76 COSMIC
COSN30481095 91 COSMIC
COSN26978320 114 COSMIC
COSN31592871 135 COSMIC
COSN2162301 170 COSMIC
COSN28793218 179 COSMIC
COSN27751805 182 COSMIC
COSN26436838 184 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753993600 4 dbSNP
rs532924817 6 dbSNP
rs780170276 10 dbSNP
rs1401897687 14 dbSNP
rs369635582 20 dbSNP
rs750445590 21 dbSNP
rs1382096026 26 dbSNP
rs767673342 27 dbSNP
rs1405448534 28 dbSNP
rs757832000 43 dbSNP
rs752166155 45 dbSNP
rs1428131762 48 dbSNP
rs564191998 50 dbSNP
rs763418440 51 dbSNP
rs776310393 54 dbSNP
rs1337944430 55 dbSNP
rs1216446180 61 dbSNP
rs765973123 62 dbSNP
rs945622654 64 dbSNP
rs1281249938 69 dbSNP
rs765429358 71 dbSNP
rs1220147051 74 dbSNP
rs550667287 75 dbSNP
rs772568541 76 dbSNP
rs771638993 77 dbSNP
rs1442713352 78 dbSNP
rs1205143673 87 dbSNP
rs748066044 88 dbSNP
rs530778535 92 dbSNP
rs766229675 95 dbSNP
rs886061398 95 dbSNP
rs991862449 107 dbSNP
rs563735928 116 dbSNP
rs1430006532 118 dbSNP
rs779946057 121 dbSNP
rs1471106042 126 dbSNP
rs561765885 130 dbSNP
rs746164916 135 dbSNP
rs185563779 136 dbSNP
rs781403617 137 dbSNP
rs1371538673 155 dbSNP
rs1300044044 161 dbSNP
rs987806219 173 dbSNP
rs1325266998 178 dbSNP
rs886061397 179 dbSNP
rs950638379 188 dbSNP
rs1026756617 193 dbSNP
rs1375168314 196 dbSNP
rs193113615 197 dbSNP
rs886061396 205 dbSNP
rs1326080856 213 dbSNP
rs1202118453 218 dbSNP
rs1009871837 219 dbSNP
rs3749920 220 dbSNP
rs779998898 221 dbSNP
rs1263209973 230 dbSNP
rs1396183532 232 dbSNP
rs546035880 240 dbSNP
rs1417993195 241 dbSNP
rs1481313075 242 dbSNP
rs1173904458 244 dbSNP
rs1247998467 249 dbSNP
rs1457955943 251 dbSNP
rs1002211821 256 dbSNP
rs1483280340 262 dbSNP
rs1382208456 272 dbSNP
rs906709397 274 dbSNP
rs73733110 295 dbSNP
rs1208436132 299 dbSNP
rs1039096573 304 dbSNP
rs1010260580 305 dbSNP
rs1322472250 306 dbSNP
rs892707347 310 dbSNP
rs1239273714 322 dbSNP
rs943440831 326 dbSNP
rs557852892 331 dbSNP
rs909350237 357 dbSNP
rs1203994599 360 dbSNP
rs186489645 362 dbSNP
rs575291397 367 dbSNP
rs1197086183 377 dbSNP
rs925569407 387 dbSNP
rs1256513271 389 dbSNP
rs1267913513 395 dbSNP
rs766840978 402 dbSNP
rs1161529548 406 dbSNP
rs1362231055 410 dbSNP
rs1453190340 416 dbSNP
rs1163849557 417 dbSNP
rs943070875 423 dbSNP
rs555435194 428 dbSNP
rs114573886 429 dbSNP
rs140024841 433 dbSNP
rs1308703192 434 dbSNP
rs1314721949 440 dbSNP
rs760356 444 dbSNP
rs1291842196 445 dbSNP
rs546875323 447 dbSNP
rs919179270 449 dbSNP
rs886061395 451 dbSNP
rs963357679 456 dbSNP
rs9471797 457 dbSNP
rs570325744 458 dbSNP
rs1158441932 461 dbSNP
rs1188386745 462 dbSNP
rs980456179 467 dbSNP
rs970820387 469 dbSNP
rs553293511 472 dbSNP
rs183630773 473 dbSNP
rs143063040 477 dbSNP
rs1296761515 478 dbSNP
rs113734032 480 dbSNP
rs1001081272 481 dbSNP
rs1390429063 482 dbSNP
rs7764586 488 dbSNP
rs1038695338 489 dbSNP
rs528492770 499 dbSNP
rs886061394 502 dbSNP
rs13211352 503 dbSNP
rs546491968 507 dbSNP
rs1262607912 508 dbSNP
rs1204535763 513 dbSNP
rs901809411 515 dbSNP
rs1442864232 520 dbSNP
rs577487022 522 dbSNP
rs1291660188 523 dbSNP
rs1420877705 526 dbSNP
rs1235533565 527 dbSNP
rs746052096 527 dbSNP
rs919050640 533 dbSNP
rs973308361 535 dbSNP
rs1318286253 536 dbSNP
rs1381065989 543 dbSNP
rs1407753487 547 dbSNP
rs1449868404 548 dbSNP
rs1335427852 550 dbSNP
rs1362629865 552 dbSNP
rs1387756267 559 dbSNP
rs1322039739 560 dbSNP
rs1293252317 564 dbSNP
rs963242690 565 dbSNP
rs1265267805 567 dbSNP
rs563900884 571 dbSNP
rs887886080 573 dbSNP
rs1162276891 576 dbSNP
rs1242744061 580 dbSNP
rs926650665 580 dbSNP
rs138314395 581 dbSNP
rs1419352944 588 dbSNP
rs1192163480 601 dbSNP
rs1426708273 603 dbSNP
rs575449935 615 dbSNP
rs150308756 618 dbSNP
rs535059110 621 dbSNP
rs572802574 624 dbSNP
rs919500522 625 dbSNP
rs1287054655 636 dbSNP
rs1209511108 640 dbSNP
rs1284936243 641 dbSNP
rs1010025033 642 dbSNP
rs1223129782 647 dbSNP
rs1285115164 649 dbSNP
rs1271532907 650 dbSNP
rs1215747054 658 dbSNP
rs1213644652 661 dbSNP
rs1242075517 662 dbSNP
rs1490641336 663 dbSNP
rs1202101133 665 dbSNP
rs140229339 666 dbSNP
rs1479287383 675 dbSNP
rs936664692 676 dbSNP
rs1171655775 677 dbSNP
rs939615301 678 dbSNP
rs1270036815 680 dbSNP
rs926264770 687 dbSNP
rs1328775376 688 dbSNP
rs146652803 701 dbSNP
rs1304799905 702 dbSNP
rs1435207191 706 dbSNP
rs1393033387 707 dbSNP
rs1404044131 716 dbSNP
rs1323517629 717 dbSNP
rs1406775802 719 dbSNP
rs1375747823 720 dbSNP
rs1474644247 720 dbSNP
rs199672594 720 dbSNP
rs781581603 720 dbSNP
rs1390976416 721 dbSNP
rs202012954 722 dbSNP
rs980425058 723 dbSNP
rs1233125139 724 dbSNP
rs1391951947 725 dbSNP
rs967755384 728 dbSNP
rs1032481927 735 dbSNP
rs1453905919 735 dbSNP
rs1251263141 736 dbSNP
rs1001135070 738 dbSNP
rs988375421 744 dbSNP
rs570288265 745 dbSNP
rs900065896 747 dbSNP
rs1329238035 749 dbSNP
rs1356541250 751 dbSNP
rs1017309873 752 dbSNP
rs1308699072 752 dbSNP
rs998072847 752 dbSNP
rs1007218459 753 dbSNP
rs1313597056 754 dbSNP
rs1359289452 756 dbSNP
rs1196796036 759 dbSNP
rs1341840861 759 dbSNP
rs886061393 767 dbSNP
rs1439264227 769 dbSNP
rs1017598227 772 dbSNP
rs144675650 780 dbSNP
rs1444718371 781 dbSNP
rs1051530400 782 dbSNP
rs537147201 788 dbSNP
rs897681948 789 dbSNP
rs1472412288 790 dbSNP
rs1300683802 794 dbSNP
rs1168318965 795 dbSNP
rs1407951167 796 dbSNP
rs868014210 796 dbSNP
rs1372921255 799 dbSNP
rs773879284 817 dbSNP
rs1330941841 818 dbSNP
rs1037481937 819 dbSNP
rs1454670713 825 dbSNP
rs897960745 827 dbSNP
rs568172984 832 dbSNP
rs1340444055 834 dbSNP
rs1327687395 839 dbSNP
rs1389472640 845 dbSNP
rs1272346762 846 dbSNP
rs1337868920 847 dbSNP
rs1218330843 849 dbSNP
rs1372136766 855 dbSNP
rs1194773722 856 dbSNP
rs1168959485 862 dbSNP
rs1461449426 864 dbSNP
rs548674194 868 dbSNP
rs980780119 875 dbSNP
rs949414194 876 dbSNP
rs1374661314 881 dbSNP
rs1044701248 898 dbSNP
rs1174462764 903 dbSNP
rs1169640887 916 dbSNP
rs1478360844 919 dbSNP
rs917874900 925 dbSNP
rs114824449 928 dbSNP
rs866175415 938 dbSNP
rs369454943 945 dbSNP
rs1401569226 947 dbSNP
rs753419175 948 dbSNP
rs566086888 961 dbSNP
rs1320854522 965 dbSNP
rs1325156658 967 dbSNP
rs1253035567 968 dbSNP
rs1284298952 979 dbSNP
rs1323859813 985 dbSNP
rs1224958239 988 dbSNP
rs1253828433 991 dbSNP
rs114197333 997 dbSNP
rs1205166520 1003 dbSNP
rs1263796950 1007 dbSNP
rs1445189352 1011 dbSNP
rs532891332 1016 dbSNP
rs1269327818 1017 dbSNP
rs45569036 1018 dbSNP
rs1018534791 1020 dbSNP
rs1197552007 1020 dbSNP
rs772214180 1020 dbSNP
rs1454399796 1022 dbSNP
rs1160322656 1023 dbSNP
rs923919082 1027 dbSNP
rs1220457327 1031 dbSNP
rs1419591224 1047 dbSNP
rs1345035017 1063 dbSNP
rs1347759026 1064 dbSNP
rs1278612724 1066 dbSNP
rs1403423270 1073 dbSNP
rs963943242 1084 dbSNP
rs76451756 1088 dbSNP
rs1239201322 1095 dbSNP
rs890141254 1103 dbSNP
rs140874488 1106 dbSNP
rs1351508297 1110 dbSNP
rs1373569583 1111 dbSNP
rs1336032395 1112 dbSNP
rs1490780618 1113 dbSNP
rs150993109 1125 dbSNP
rs115180990 1126 dbSNP
rs1266966279 1127 dbSNP
rs1470274724 1133 dbSNP
rs1028078823 1136 dbSNP
rs1407300321 1148 dbSNP
rs993569426 1155 dbSNP
rs897924481 1166 dbSNP
rs199889408 1168 dbSNP
rs1164782961 1169 dbSNP
rs572720377 1172 dbSNP
rs1473721827 1173 dbSNP
rs1423159045 1178 dbSNP
rs1293285077 1180 dbSNP
rs776885173 1185 dbSNP
rs1037534356 1189 dbSNP
rs941867453 1196 dbSNP
rs375433887 1199 dbSNP
rs1211378141 1201 dbSNP
rs75437254 1203 dbSNP
rs545684763 1204 dbSNP
rs1264602033 1206 dbSNP
rs1481118310 1209 dbSNP
rs1283005344 1210 dbSNP
rs1226027603 1211 dbSNP
rs1457397593 1212 dbSNP
rs1387690043 1215 dbSNP
rs946965411 1218 dbSNP
rs1164599156 1221 dbSNP
rs1330855256 1224 dbSNP
rs375709630 1232 dbSNP
rs1232474333 1233 dbSNP
rs1397622938 1234 dbSNP
rs565671235 1245 dbSNP
rs893441773 1259 dbSNP
rs548960052 1263 dbSNP
rs1384956041 1282 dbSNP
rs760820209 1293 dbSNP
rs748956902 1296 dbSNP
rs935076029 1305 dbSNP
rs922373453 1306 dbSNP
rs1229248896 1311 dbSNP
rs1448717377 1314 dbSNP
rs536811796 1316 dbSNP
rs1997980 1318 dbSNP
rs1482596187 1328 dbSNP
rs572947703 1335 dbSNP
rs1458880627 1336 dbSNP
rs1181806178 1346 dbSNP
rs925350705 1353 dbSNP
rs911061380 1357 dbSNP
rs979635520 1358 dbSNP
rs1168916945 1362 dbSNP
rs1421085236 1375 dbSNP
rs755840643 1378 dbSNP
rs1176607440 1389 dbSNP
rs964215480 1413 dbSNP
rs1445096092 1414 dbSNP
rs1018425190 1416 dbSNP
rs1362515597 1429 dbSNP
rs987090107 1440 dbSNP
rs955796530 1455 dbSNP
rs1317597149 1471 dbSNP
rs1027634180 1482 dbSNP
rs1416355618 1494 dbSNP
rs1030029227 1495 dbSNP
rs962141873 1501 dbSNP
rs745838718 1502 dbSNP
rs1003583745 1519 dbSNP
rs1192002335 1522 dbSNP
rs905333703 1524 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucUCGUUCUGGGGCAGAGAuuu 5'
            :|::| |||||||||||   
Target 5' ggGGUGAAACCCCGUCUCU--- 3'
 		1 - 19
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000230361.3 | 3UTR | GGGGUGAAACCCCGUCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.742 1.8e-3 -0.742 1.8e-3 13 Click to see details
GSE26953 Aortic valvular endothelial cells -0.44 1.6e-2 -0.391 2.9e-2 24 Click to see details
GSE28544 Breast cancer 0.398 2.7e-2 0.253 1.2e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.242 1.2e-1 -0.082 3.5e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells 0.08 3.6e-1 0.080 3.6e-1 23 Click to see details
GSE32688 Pancreatic cancer 0.039 4.2e-1 0.076 3.4e-1 32 Click to see details
GSE38226 Liver fibrosis 0.033 4.4e-1 0.129 2.9e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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