miRTarBase - #MIRT621667


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pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol UBE4B   
Synonyms E4, HDNB1, UBOX3, UFD2, UFD2A
Description ubiquitination factor E4B
Transcript NM_001105562   
Other Transcripts NM_006048   
Expression
Putative miRNA Targets on UBE4B
3'UTR of UBE4B
(miRNA target sites are highlighted)		 
>UBE4B|NM_001105562|3'UTR
   1 ACCGTTCCGCCGCCCACCCTCTGCTAGACACAGCCAAGGCCAACGAGGCAAGCAGAAGCAGCGGCCGCAGCGAAGCTGCC
  81 GTTCATGTGTTGGAGGCCAAATGTGGCAAACCAACCCCAGGCCCACCCAGAGCGAGCAAACGCTGAGACCTGAAAGGACA
 161 TGGATGAGAAGAGGAGCCCGCTTCCTGTACATATATTTAAGTGACAAACACGGTCAAAAGCTTAAGGGACAGGTTTTATG
 241 GTTGCTTGTGTAATAAAGCATGTCCTTCGTATGTCACAGTTTGGGGCAACGGAAGTCTTTTAGTGATGGCTAATGGGTCT
 321 GGGCAGCATCCCTTCATGAATTTTTTTTTAATCCAATATCCGTTGATTTGATTGTGATTAGAGAACCTTGGACATTTTGC
 401 TGCTAAAGAATCTTTTTTCCCCTCTCCCCCTTCCTGACCCTACTTGCACTGCTGTGGATTTTTTTAAGAGAAGCAAAAAC
 481 AAAAGTAAACTCCTTTCCCTGGCCCTCCAAACATATATTCTGTGAGATAACTGTGCCTGCTACCAAGTGTTAATCCTGGG
 561 ATCGTATTTTTATATCATATTCACATATTTGTTTTTTTAATTGGTGTTAGATGACATGATTAATAAAAAAGGCAAGATAT
 641 TTTCAGAATTTGAATTTCAGTTTTTTTTTTCTTTTGAAATGTCCCTTTAAGATTTTTTTATTCTAAACAAAATAAAGAAA
 721 ATCCTGCTGCTCTGGTCCTTGTGATAAGCCTCTCTTCGGCATCTGAGGAGCAGCTGCAGCAAAATCTAGGGGTGTAAGTG
 801 TATCAGGACTTATGTGACTTATATTTTGGGGAGATGAGGGTTGGGTTTTTTTTTTAATGCTACGTGACAGTTTGAAACCT
 881 TCACAGTTATCCTCTGGGGGTAAATCAATTCTTCAACCCTTGGGTGTGTGAGTTTGAGGCAGGGTCATTTGTGTGATGTG
 961 TTTGGCCTTACCAAAGCAAAAGAGGGTGCAAGAATGTGGGAGTATGTCTGCCGGTTTCAACACACACAGACAAACACAGC
1041 CACACGCGCACACAAGTATAAGACTTTTTGTATTACTGCTCCCTACTTAACATACTTGAATTCTCAAATTTCCTTTGGGG
1121 TAAAAAAAAAAAAAGGATTTGAAACCATAAAGTGTTCTGAAGAAATTAAGTCTATAAAAAGCATACTTTCTTTTTTCTTT
1201 TCCTTTTTTCCCTCCACAGACAATGTCCTCTGTTCAATTCCTAACGCAAACTACAATAAATGGTGACACACGTTCAGAAG
1281 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cacacGAGAGACC---A-GUUGGUAg 5'
               :|| ||||   | ||| ||| 
Target 5' ctcctTTCCCTGGCCCTCCAAACATa 3'
 490 - 515 121.00 -9.46
2 
miRNA  3' cacacgagagaccagUUGGUAg 5'
                         |||||| 
Target 5' aaaaaaaggatttgaAACCATa 3'
 1128 - 1149 120.00 -6.90
3 
miRNA  3' cacacgaGAGACCAGUUGGUAg 5'
                 :|||  |||||| | 
Target 5' aaatcaaTTCT--TCAACCCTt 3'
 902 - 921 119.00 -7.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32068395 3 COSMIC
COSN30108350 5 COSMIC
COSN30103497 6 COSMIC
COSN27000932 10 COSMIC
COSN30497910 11 COSMIC
COSN30454189 12 COSMIC
COSN27000940 13 COSMIC
COSN30178161 18 COSMIC
COSN26879980 46 COSMIC
COSN30493278 63 COSMIC
COSN31598333 64 COSMIC
COSN13450798 73 COSMIC
COSN19617430 81 COSMIC
COSN30612587 84 COSMIC
COSN24308156 185 COSMIC
COSN28153403 246 COSMIC
COSN1395799 311 COSMIC
COSN31530157 368 COSMIC
COSN15823558 385 COSMIC
COSN31542448 447 COSMIC
COSN15081048 601 COSMIC
COSN26567898 619 COSMIC
COSN31606202 671 COSMIC
COSN31567407 672 COSMIC
COSN27308973 856 COSMIC
COSN31554887 864 COSMIC
COSN31488130 915 COSMIC
COSN31567687 967 COSMIC
COSN26585934 1015 COSMIC
COSN26567272 1049 COSMIC
COSN26649973 1049 COSMIC
COSN31530433 1104 COSMIC
COSN20094286 1135 COSMIC
COSN31540478 1161 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1351539418 3 dbSNP
rs977834519 4 dbSNP
rs751211114 5 dbSNP
rs756912152 8 dbSNP
rs767229317 9 dbSNP
rs764484000 10 dbSNP
rs374151375 12 dbSNP
rs377106861 13 dbSNP
rs749233193 16 dbSNP
rs776242768 17 dbSNP
rs778733607 18 dbSNP
rs747853558 19 dbSNP
rs202048066 20 dbSNP
rs927898282 21 dbSNP
rs1251654402 28 dbSNP
rs935242462 35 dbSNP
rs370473673 36 dbSNP
rs1357944512 37 dbSNP
rs374963174 42 dbSNP
rs745964261 43 dbSNP
rs549045105 45 dbSNP
rs775930352 46 dbSNP
rs1439868227 49 dbSNP
rs921636901 63 dbSNP
rs931862957 64 dbSNP
rs371742248 67 dbSNP
rs374654837 68 dbSNP
rs1305322777 70 dbSNP
rs185790354 72 dbSNP
rs1036428316 73 dbSNP
rs1284077728 75 dbSNP
rs1046277 81 dbSNP
rs144033579 85 dbSNP
rs901461942 86 dbSNP
rs1056176282 92 dbSNP
rs1424125520 93 dbSNP
rs1186810307 106 dbSNP
rs145974529 112 dbSNP
rs994422578 118 dbSNP
rs1390798172 119 dbSNP
rs1429350637 120 dbSNP
rs1296629920 124 dbSNP
rs1404830927 134 dbSNP
rs1014506342 135 dbSNP
rs190316525 142 dbSNP
rs952318025 143 dbSNP
rs1230050716 150 dbSNP
rs540413491 151 dbSNP
rs1023360437 161 dbSNP
rs182131511 163 dbSNP
rs1483477488 178 dbSNP
rs927815597 179 dbSNP
rs1254063603 181 dbSNP
rs1466206769 185 dbSNP
rs1189057056 186 dbSNP
rs1248760416 194 dbSNP
rs1196547469 195 dbSNP
rs1033196827 203 dbSNP
rs1168668031 206 dbSNP
rs76752810 210 dbSNP
rs989249909 212 dbSNP
rs921570171 213 dbSNP
rs1367341180 224 dbSNP
rs1183962247 227 dbSNP
rs1437910454 242 dbSNP
rs113941904 243 dbSNP
rs953080850 253 dbSNP
rs758304065 265 dbSNP
rs544160201 270 dbSNP
rs911831804 279 dbSNP
rs1379992442 289 dbSNP
rs562858250 291 dbSNP
rs533430233 293 dbSNP
rs1175892771 301 dbSNP
rs920458189 302 dbSNP
rs762670012 310 dbSNP
rs942798429 310 dbSNP
rs1041644253 311 dbSNP
rs1209304198 313 dbSNP
rs552028542 314 dbSNP
rs901307460 318 dbSNP
rs1471133109 321 dbSNP
rs1166548800 327 dbSNP
rs1396280600 331 dbSNP
rs879294944 333 dbSNP
rs1269813760 337 dbSNP
rs994830674 341 dbSNP
rs1198347903 349 dbSNP
rs185845233 350 dbSNP
rs1331539497 362 dbSNP
rs190150965 363 dbSNP
rs376052574 373 dbSNP
rs1403814698 377 dbSNP
rs1160601569 379 dbSNP
rs1388537550 381 dbSNP
rs930682853 387 dbSNP
rs1367610835 409 dbSNP
rs748781264 413 dbSNP
rs1385903507 414 dbSNP
rs1280921536 422 dbSNP
rs1352155788 425 dbSNP
rs549144161 430 dbSNP
rs888125278 431 dbSNP
rs1223606726 440 dbSNP
rs1005249773 443 dbSNP
rs1250524922 444 dbSNP
rs1023285520 448 dbSNP
rs567320906 449 dbSNP
rs767888686 459 dbSNP
rs1266995766 465 dbSNP
rs894478462 480 dbSNP
rs981874128 483 dbSNP
rs1339896357 484 dbSNP
rs1420792326 492 dbSNP
rs375217063 492 dbSNP
rs1411614489 493 dbSNP
rs956544895 494 dbSNP
rs1167477385 499 dbSNP
rs1046003078 507 dbSNP
rs915189062 508 dbSNP
rs1300951707 509 dbSNP
rs1372018211 511 dbSNP
rs537847254 529 dbSNP
rs757634265 532 dbSNP
rs978771900 548 dbSNP
rs549777823 549 dbSNP
rs1269821860 565 dbSNP
rs571243862 573 dbSNP
rs765985461 576 dbSNP
rs1313284568 588 dbSNP
rs942787810 589 dbSNP
rs1245328613 591 dbSNP
rs1372860840 592 dbSNP
rs538592907 593 dbSNP
rs1484166778 597 dbSNP
rs1033558109 600 dbSNP
rs1206054799 601 dbSNP
rs1232693942 602 dbSNP
rs780988992 612 dbSNP
rs1184164545 625 dbSNP
rs554027092 625 dbSNP
rs1415120021 633 dbSNP
rs1170090307 645 dbSNP
rs893314692 649 dbSNP
rs1364274498 658 dbSNP
rs549773031 661 dbSNP
rs901355488 661 dbSNP
rs1047247771 662 dbSNP
rs1303193094 670 dbSNP
rs1346897335 672 dbSNP
rs866076887 684 dbSNP
rs1380154758 685 dbSNP
rs1352570001 686 dbSNP
rs1449913070 689 dbSNP
rs888723495 693 dbSNP
rs12759922 704 dbSNP
rs1011062690 705 dbSNP
rs1326738714 709 dbSNP
rs1243600647 713 dbSNP
rs748586286 714 dbSNP
rs1005802243 723 dbSNP
rs572195224 728 dbSNP
rs904819761 730 dbSNP
rs1272531516 749 dbSNP
rs1292563639 758 dbSNP
rs953029976 759 dbSNP
rs1238617196 766 dbSNP
rs1461274960 779 dbSNP
rs1489540571 782 dbSNP
rs987125312 791 dbSNP
rs1249385328 793 dbSNP
rs1018576998 797 dbSNP
rs1203546347 801 dbSNP
rs749440881 803 dbSNP
rs553914569 804 dbSNP
rs1416013955 807 dbSNP
rs1416940258 807 dbSNP
rs1176536639 814 dbSNP
rs1034749490 815 dbSNP
rs536400718 819 dbSNP
rs77474955 820 dbSNP
rs868428926 822 dbSNP
rs1322403845 823 dbSNP
rs1195819778 834 dbSNP
rs1383817568 835 dbSNP
rs1009380583 840 dbSNP
rs1022083691 841 dbSNP
rs967972664 846 dbSNP
rs972008876 846 dbSNP
rs985978320 846 dbSNP
rs1221096977 847 dbSNP
rs1444535204 849 dbSNP
rs1279793571 853 dbSNP
rs920389785 854 dbSNP
rs1323232483 858 dbSNP
rs1164837244 859 dbSNP
rs1465007217 860 dbSNP
rs573763512 863 dbSNP
rs544221039 864 dbSNP
rs1478806747 865 dbSNP
rs1287869794 867 dbSNP
rs1385256640 872 dbSNP
rs1383668659 880 dbSNP
rs1191373745 881 dbSNP
rs1428364240 885 dbSNP
rs1468015308 895 dbSNP
rs977254626 898 dbSNP
rs1312607510 907 dbSNP
rs1381832421 909 dbSNP
rs1401420019 917 dbSNP
rs922739524 927 dbSNP
rs1324693691 929 dbSNP
rs930031726 945 dbSNP
rs1275615541 958 dbSNP
rs1323516066 959 dbSNP
rs1345331956 961 dbSNP
rs1237001603 966 dbSNP
rs1047298226 972 dbSNP
rs1330440175 976 dbSNP
rs916026824 977 dbSNP
rs1260321399 981 dbSNP
rs941599004 1001 dbSNP
rs1045299924 1003 dbSNP
rs1221909114 1013 dbSNP
rs950127274 1014 dbSNP
rs1045739184 1022 dbSNP
rs1479372893 1023 dbSNP
rs1003241872 1026 dbSNP
rs1241667374 1032 dbSNP
rs556166585 1036 dbSNP
rs1469568475 1040 dbSNP
rs181086651 1046 dbSNP
rs185168785 1047 dbSNP
rs560834719 1048 dbSNP
rs1009264374 1049 dbSNP
rs1054751020 1053 dbSNP
rs1416745498 1057 dbSNP
rs758993135 1059 dbSNP
rs1403271540 1071 dbSNP
rs1157776345 1084 dbSNP
rs1336681182 1086 dbSNP
rs967815967 1091 dbSNP
rs1007450363 1093 dbSNP
rs893289286 1097 dbSNP
rs1228389501 1101 dbSNP
rs966342929 1108 dbSNP
rs1206775371 1112 dbSNP
rs1164305906 1122 dbSNP
rs1252313534 1122 dbSNP
rs1436968748 1122 dbSNP
rs1473857245 1122 dbSNP
rs34197778 1122 dbSNP
rs397860858 1122 dbSNP
rs397979175 1122 dbSNP
rs1384610725 1124 dbSNP
rs922590811 1134 dbSNP
rs951475152 1136 dbSNP
rs527881002 1149 dbSNP
rs997046058 1150 dbSNP
rs910051359 1153 dbSNP
rs1455003151 1155 dbSNP
rs757267546 1157 dbSNP
rs1334354086 1167 dbSNP
rs1313741204 1171 dbSNP
rs1405080309 1175 dbSNP
rs1453117269 1184 dbSNP
rs1230191886 1185 dbSNP
rs1274888386 1188 dbSNP
rs1338552349 1197 dbSNP
rs1338568186 1198 dbSNP
rs1371131230 1203 dbSNP
rs1223186787 1204 dbSNP
rs369539347 1210 dbSNP
rs1306351121 1211 dbSNP
rs1317651140 1212 dbSNP
rs1230456908 1213 dbSNP
rs779110644 1224 dbSNP
rs1261498406 1226 dbSNP
rs926921333 1227 dbSNP
rs1182864760 1235 dbSNP
rs1323205296 1236 dbSNP
rs1204738989 1238 dbSNP
rs1170759954 1244 dbSNP
rs1239687363 1247 dbSNP
rs1479928326 1272 dbSNP
rs543200132 1273 dbSNP
rs557206867 1276 dbSNP
rs796474157 1281 dbSNP
rs1404719013 1284 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000343090.6 | 3UTR | AAAAAAAAAAAGGAUUUGAAACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000343090.6 | 3UTR | AAAAAAGGAUUUGAAACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000343090.6 | 3UTR | CAAAUUUCCUUUGGGGUAAAAAAAAAAAAAGGAUUUGAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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