pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TMEM233   
Synonyms DSPB2, IFITMD2
Description transmembrane protein 233
Transcript NM_001136534   
Expression
Putative miRNA Targets on TMEM233
3'UTR of TMEM233
(miRNA target sites are highlighted)
>TMEM233|NM_001136534|3'UTR
   1 GGAACCAGCGGTCAGTGGGCTGTGAGCGTGGAGGATGGACCTCATCCACACACACCCCAAAGGAGTTTCTAAGGAATGGA
  81 TCCTTGACTTCAGACTGTGAGATCTTTTCCTCCAGGACTCTCCAGAGGCAGGTCCCTGGCAAATGAACAAGAAAAAAAAA
 161 AAAAAAAAGTCCAAAATTTAGGCAATCCAAGCTGCACAGCCGGATCAGCCAAAGTCATTGATTTGTAAAAATGAAAAGAA
 241 AACAGAAAAAAGAAAAATGAAGTCTCACTGTCTCAGTTTAGCGAATCCCGTTGTGTCCACTCCTGTCCTCCAGAGGCGAG
 321 CCTCAGGAAATCACATAACTTTTCACTGAGGGGATCCAGGGGGTCTCCATATAGGGGGAGATGGAGGTTTCTAGGAAGAG
 401 CAGCAGGTGCTGGTATTTACAATGTTGAGCACAAACATTTGCAGCATGTTTAAAATTGTCTAGTAGAGTTCAAGTTGTGG
 481 ATTTGCTTTTCCTTTTATTCTTATAACCTTCAGTAACTCCTCCTCTGGGAGTCAGCACTCCCATGCCCAGAGTTCACCCA
 561 TCTGGTCATCAAACACTCAAAGAAGGGGCTTTTCTGGCCTTTTGTCTTGATGCTTATATTTCCAAATAGGCCCCCTCCCT
 641 TGCTTGCATCCACGTTGGTCAACTTGACCAAAACCTCACTCTTCACTCAAACAGGCTCTGAGAATGGACTTAGTGGCCAA
 721 TTCTAGGTACATGAGCACTTCCTGTATCCCAGTTTTGGGAATAAACTGGCTGTATTTATAGAATGTGCTTTTTTTTTTTC
 801 AATTTCTCACTCTCTCTCCTATCTCTAGCAAGTCTCAGGCAAGATCTTTGATT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaUACCCACCCUGUCUCUCCc 5'
            || || |||| | :|||| 
Target 5' atATAGG-GGGAGATGGAGGt 3'
369 - 388 118.00 -15.90
2
miRNA  3' gauACCCACCCU--GUCUCUCcc 5'
             || | ||||  |||:|:|  
Target 5' cacTGAG-GGGATCCAGGGGGtc 3'
344 - 365 107.00 -17.00
3
miRNA  3' gauacccacccuGUCUC--UCCc 5'
                      |||||  ||| 
Target 5' tccaggactctcCAGAGGCAGGt 3'
111 - 133 105.00 -9.52
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24535734 28 COSMIC
COSN6613480 68 COSMIC
COSN15152396 70 COSMIC
COSN31574201 105 COSMIC
COSN30705910 109 COSMIC
COSN18714426 149 COSMIC
COSN20110202 156 COSMIC
COSN28934669 156 COSMIC
COSN7313185 158 COSMIC
COSN20110201 169 COSMIC
COSN27316019 169 COSMIC
COSN25686844 474 COSMIC
COSN20253501 632 COSMIC
COSN8697809 721 COSMIC
COSN20110204 800 COSMIC
COSN7313186 832 COSMIC
COSN27297206 966 COSMIC
COSN61559 1068 COSMIC
COSN18981422 1237 COSMIC
COSN21519660 1394 COSMIC
COSN24479986 1440 COSMIC
COSN5932468 1604 COSMIC
COSN16620025 1717 COSMIC
COSN19466369 1764 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1310708629 5 dbSNP
rs1337445244 7 dbSNP
rs1195289068 8 dbSNP
rs1251393503 9 dbSNP
rs778499831 10 dbSNP
rs192875739 11 dbSNP
rs904634282 16 dbSNP
rs1445635085 18 dbSNP
rs1165953312 22 dbSNP
rs757867015 23 dbSNP
rs781693510 28 dbSNP
rs371431088 29 dbSNP
rs1421347312 37 dbSNP
rs1396645947 39 dbSNP
rs147991893 42 dbSNP
rs1437723779 58 dbSNP
rs1345543019 61 dbSNP
rs1191299577 62 dbSNP
rs1432684614 67 dbSNP
rs2301655 68 dbSNP
rs1366757767 70 dbSNP
rs1014182056 94 dbSNP
rs1356380095 105 dbSNP
rs1022772839 121 dbSNP
rs1234938639 123 dbSNP
rs1304251017 141 dbSNP
rs1315690843 145 dbSNP
rs1303959465 146 dbSNP
rs1387437198 146 dbSNP
rs1275593345 149 dbSNP
rs77134346 149 dbSNP
rs1350220766 150 dbSNP
rs1176632817 151 dbSNP
rs1216346646 152 dbSNP
rs386377919 152 dbSNP
rs56347532 152 dbSNP
rs778739196 152 dbSNP
rs79201920 152 dbSNP
rs200103177 154 dbSNP
rs111558498 155 dbSNP
rs866962550 155 dbSNP
rs59983963 156 dbSNP
rs112499561 157 dbSNP
rs1341397133 160 dbSNP
rs978546455 160 dbSNP
rs1297749153 167 dbSNP
rs923977098 169 dbSNP
rs568960754 170 dbSNP
rs1005413092 171 dbSNP
rs61300826 173 dbSNP
rs1172225506 183 dbSNP
rs1468374819 191 dbSNP
rs141572649 198 dbSNP
rs1017077004 200 dbSNP
rs1396345100 202 dbSNP
rs961144918 203 dbSNP
rs1040654019 211 dbSNP
rs1483221759 219 dbSNP
rs922167454 224 dbSNP
rs1200608762 227 dbSNP
rs371011534 233 dbSNP
rs1402106922 234 dbSNP
rs1277872340 246 dbSNP
rs1225513504 254 dbSNP
rs1342089062 277 dbSNP
rs557809439 283 dbSNP
rs774981381 284 dbSNP
rs559692837 290 dbSNP
rs1349156821 291 dbSNP
rs1333214296 298 dbSNP
rs954936216 306 dbSNP
rs887907851 308 dbSNP
rs1005268376 313 dbSNP
rs988143282 318 dbSNP
rs183349355 319 dbSNP
rs1373249196 326 dbSNP
rs1444611535 336 dbSNP
rs1188718627 337 dbSNP
rs1444320448 347 dbSNP
rs943517221 348 dbSNP
rs1241849754 349 dbSNP
rs1439155914 357 dbSNP
rs1257474074 358 dbSNP
rs1279062765 363 dbSNP
rs1351605155 364 dbSNP
rs1003606995 366 dbSNP
rs1225690395 374 dbSNP
rs1266223869 377 dbSNP
rs539868502 379 dbSNP
rs1380284675 387 dbSNP
rs1334672514 405 dbSNP
rs1214836882 423 dbSNP
rs553434068 424 dbSNP
rs1012129056 426 dbSNP
rs1326303998 428 dbSNP
rs1387966400 431 dbSNP
rs926017587 432 dbSNP
rs934739489 444 dbSNP
rs1162219102 445 dbSNP
rs187788399 447 dbSNP
rs1424492566 451 dbSNP
rs1232965119 466 dbSNP
rs967843324 476 dbSNP
rs1053068168 480 dbSNP
rs542336266 486 dbSNP
rs978221031 487 dbSNP
rs1031487440 500 dbSNP
rs1453336875 501 dbSNP
rs1470957214 505 dbSNP
rs1268386561 513 dbSNP
rs895837884 514 dbSNP
rs1161157024 526 dbSNP
rs976483639 530 dbSNP
rs1352936213 534 dbSNP
rs1277632014 539 dbSNP
rs1438003590 545 dbSNP
rs949969026 546 dbSNP
rs1331167507 553 dbSNP
rs1044691820 559 dbSNP
rs1166873591 560 dbSNP
rs1364153581 561 dbSNP
rs1397969495 568 dbSNP
rs1420652572 577 dbSNP
rs1407904268 578 dbSNP
rs905804466 579 dbSNP
rs1005789975 582 dbSNP
rs1378240173 583 dbSNP
rs932239085 587 dbSNP
rs1038174675 608 dbSNP
rs896871953 611 dbSNP
rs1123790 613 dbSNP
rs531018436 617 dbSNP
rs1446154724 629 dbSNP
rs1444616130 632 dbSNP
rs1282688475 636 dbSNP
rs1355187010 640 dbSNP
rs1220869134 642 dbSNP
rs372973585 655 dbSNP
rs1221104481 656 dbSNP
rs955029965 663 dbSNP
rs1278365292 670 dbSNP
rs1401010858 675 dbSNP
rs1316532299 682 dbSNP
rs77859220 696 dbSNP
rs1273084170 710 dbSNP
rs1416631117 725 dbSNP
rs757382441 729 dbSNP
rs1175834068 730 dbSNP
rs1479458543 737 dbSNP
rs1426065512 744 dbSNP
rs1194640324 747 dbSNP
rs1474999921 762 dbSNP
rs1184921933 764 dbSNP
rs1212214586 769 dbSNP
rs200887029 788 dbSNP
rs11358947 789 dbSNP
rs1201239445 789 dbSNP
rs1442961089 789 dbSNP
rs796494479 789 dbSNP
rs79055686 791 dbSNP
rs1475346341 795 dbSNP
rs1258376818 800 dbSNP
rs200124831 800 dbSNP
rs200526817 801 dbSNP
rs1421217270 802 dbSNP
rs1461418620 807 dbSNP
rs1168479173 810 dbSNP
rs1361754463 813 dbSNP
rs1268807498 817 dbSNP
rs1397271394 821 dbSNP
rs979303753 822 dbSNP
rs894777418 823 dbSNP
rs528063187 834 dbSNP
rs1468351814 847 dbSNP
rs1402544115 852 dbSNP
rs1171708053 860 dbSNP
rs956083687 865 dbSNP
rs988906533 866 dbSNP
rs1417578440 869 dbSNP
rs917367284 879 dbSNP
rs1183414543 881 dbSNP
rs779175356 882 dbSNP
rs1242477098 885 dbSNP
rs1044441444 887 dbSNP
rs903713111 893 dbSNP
rs927169198 897 dbSNP
rs1203140720 901 dbSNP
rs941290906 921 dbSNP
rs1031122004 926 dbSNP
rs146379444 927 dbSNP
rs1230411051 948 dbSNP
rs897007556 966 dbSNP
rs1227317212 967 dbSNP
rs1451090835 990 dbSNP
rs1379283567 994 dbSNP
rs993992269 997 dbSNP
rs566895910 1001 dbSNP
rs1441479867 1015 dbSNP
rs1198185858 1035 dbSNP
rs1279014641 1036 dbSNP
rs191306030 1041 dbSNP
rs1212663735 1042 dbSNP
rs4767836 1044 dbSNP
rs183753375 1047 dbSNP
rs1017945727 1057 dbSNP
rs776139730 1059 dbSNP
rs1000468978 1069 dbSNP
rs1033149047 1075 dbSNP
rs1176159141 1083 dbSNP
rs1479344675 1091 dbSNP
rs1248146624 1097 dbSNP
rs1221809105 1103 dbSNP
rs188141039 1112 dbSNP
rs956178688 1129 dbSNP
rs989001463 1131 dbSNP
rs1477012633 1136 dbSNP
rs917336209 1139 dbSNP
rs1244164054 1172 dbSNP
rs971514728 1173 dbSNP
rs1374928851 1183 dbSNP
rs940902788 1205 dbSNP
rs537697989 1206 dbSNP
rs1405771985 1210 dbSNP
rs1365133552 1212 dbSNP
rs972638553 1227 dbSNP
rs980471593 1230 dbSNP
rs1421249133 1237 dbSNP
rs1380868662 1240 dbSNP
rs1158261659 1243 dbSNP
rs1416832882 1244 dbSNP
rs1383224029 1250 dbSNP
rs558009694 1251 dbSNP
rs1490087915 1254 dbSNP
rs939103457 1257 dbSNP
rs1056195932 1270 dbSNP
rs941247974 1272 dbSNP
rs916267042 1277 dbSNP
rs747410799 1283 dbSNP
rs1303521355 1294 dbSNP
rs1224131044 1295 dbSNP
rs1345152396 1301 dbSNP
rs1328653482 1313 dbSNP
rs1281561942 1323 dbSNP
rs1232751731 1324 dbSNP
rs1401668589 1325 dbSNP
rs571240856 1331 dbSNP
rs1451525373 1336 dbSNP
rs1360767193 1339 dbSNP
rs1176524728 1341 dbSNP
rs1479800458 1344 dbSNP
rs1426795179 1345 dbSNP
rs192616845 1350 dbSNP
rs947684314 1353 dbSNP
rs929807059 1354 dbSNP
rs1262857089 1363 dbSNP
rs1302060318 1372 dbSNP
rs1186240465 1379 dbSNP
rs1485183363 1381 dbSNP
rs1258246670 1392 dbSNP
rs1204414372 1396 dbSNP
rs1050916928 1398 dbSNP
rs890838443 1401 dbSNP
rs1261547135 1407 dbSNP
rs1382486884 1412 dbSNP
rs1220692948 1427 dbSNP
rs1043694717 1433 dbSNP
rs1348055147 1436 dbSNP
rs1236008086 1437 dbSNP
rs942470436 1446 dbSNP
rs769081947 1454 dbSNP
rs1039755034 1459 dbSNP
rs553323543 1472 dbSNP
rs573302903 1473 dbSNP
rs1033245503 1476 dbSNP
rs535901385 1477 dbSNP
rs1172450762 1479 dbSNP
rs866431846 1488 dbSNP
rs1449730135 1489 dbSNP
rs901643083 1495 dbSNP
rs1193004011 1499 dbSNP
rs1258939652 1502 dbSNP
rs1184720960 1503 dbSNP
rs1010402070 1513 dbSNP
rs1454797286 1518 dbSNP
rs1241343601 1521 dbSNP
rs1200543881 1525 dbSNP
rs998023371 1529 dbSNP
rs556023313 1530 dbSNP
rs1224994269 1532 dbSNP
rs1323260239 1548 dbSNP
rs1315689504 1549 dbSNP
rs1451814501 1550 dbSNP
rs761563829 1552 dbSNP
rs1024479561 1557 dbSNP
rs1380008051 1563 dbSNP
rs1029012062 1568 dbSNP
rs953407918 1572 dbSNP
rs1395357025 1578 dbSNP
rs1006169769 1580 dbSNP
rs1387470396 1581 dbSNP
rs971863707 1588 dbSNP
rs1016510175 1593 dbSNP
rs980223243 1602 dbSNP
rs1383857118 1603 dbSNP
rs1034874884 1604 dbSNP
rs962722016 1611 dbSNP
rs1250136402 1612 dbSNP
rs974082550 1613 dbSNP
rs575790098 1615 dbSNP
rs1489376948 1622 dbSNP
rs544515049 1634 dbSNP
rs962611287 1635 dbSNP
rs918492773 1636 dbSNP
rs972305106 1641 dbSNP
rs564720821 1643 dbSNP
rs928806515 1651 dbSNP
rs960210070 1653 dbSNP
rs386766926 1665 dbSNP
rs185492794 1666 dbSNP
rs190295215 1667 dbSNP
rs1365750871 1670 dbSNP
rs560480474 1675 dbSNP
rs912417434 1677 dbSNP
rs1383946173 1678 dbSNP
rs942417641 1684 dbSNP
rs1039444087 1685 dbSNP
rs1179995883 1688 dbSNP
rs903625348 1693 dbSNP
rs1315899450 1697 dbSNP
rs10774509 1699 dbSNP
rs1052134884 1700 dbSNP
rs1205642368 1704 dbSNP
rs1349405345 1708 dbSNP
rs549454382 1717 dbSNP
rs562871473 1718 dbSNP
rs997342404 1720 dbSNP
rs1404772693 1725 dbSNP
rs1364067998 1733 dbSNP
rs1320926394 1735 dbSNP
rs1401776723 1735 dbSNP
rs1384798085 1736 dbSNP
rs1156933445 1741 dbSNP
rs1430309091 1743 dbSNP
rs1470971049 1743 dbSNP
rs1050504172 1749 dbSNP
rs1243621200 1749 dbSNP
rs1479372824 1749 dbSNP
rs1446363578 1755 dbSNP
rs531516544 1759 dbSNP
rs907354348 1760 dbSNP
rs1002132141 1764 dbSNP
rs1195516779 1765 dbSNP
rs772762493 1768 dbSNP
rs1344083534 1769 dbSNP
rs1272299709 1779 dbSNP
rs962801018 1787 dbSNP
rs974008831 1788 dbSNP
rs1025605250 1793 dbSNP
rs34341234 1800 dbSNP
rs1160187095 1803 dbSNP
rs1471022055 1806 dbSNP
rs1406922278 1820 dbSNP
rs951279270 1824 dbSNP
rs986750232 1832 dbSNP
rs1176054076 1833 dbSNP
rs551251540 1835 dbSNP
rs912499994 1838 dbSNP
rs370912064 1840 dbSNP
rs571130663 1841 dbSNP
rs762444950 1842 dbSNP
rs994171986 1842 dbSNP
rs1474931553 1843 dbSNP
rs975691746 1856 dbSNP
rs1460240635 1858 dbSNP
rs925049918 1860 dbSNP
rs139762481 1867 dbSNP
rs547295501 1869 dbSNP
rs74704292 1880 dbSNP
rs535912473 1881 dbSNP
rs1201165219 1884 dbSNP
rs991650636 1885 dbSNP
rs913582305 1891 dbSNP
rs949059779 1896 dbSNP
rs1045962831 1918 dbSNP
rs907486705 1938 dbSNP
rs1295879172 1940 dbSNP
rs1001701170 1941 dbSNP
rs1391597350 1945 dbSNP
rs1329764759 1950 dbSNP
rs1308747981 1951 dbSNP
rs1056372917 1967 dbSNP
rs898543663 1984 dbSNP
rs988488195 1987 dbSNP
rs1181247713 1988 dbSNP
rs374894231 2001 dbSNP
rs765808600 2010 dbSNP
rs11064864 2023 dbSNP
rs951372073 2026 dbSNP
rs114719516 2028 dbSNP
rs538750723 2029 dbSNP
rs1177963394 2030 dbSNP
rs144364647 2031 dbSNP
rs1314903288 2033 dbSNP
rs1474359832 2040 dbSNP
rs1187604517 2050 dbSNP
rs1280426949 2056 dbSNP
rs975239987 2057 dbSNP
rs1037765562 2058 dbSNP
rs1169024581 2065 dbSNP
rs925126123 2068 dbSNP
rs578225402 2083 dbSNP
rs957745484 2089 dbSNP
rs1462017019 2091 dbSNP
rs1299408263 2093 dbSNP
rs1364941400 2093 dbSNP
rs1161566291 2094 dbSNP
rs1225217491 2094 dbSNP
rs1270545821 2094 dbSNP
rs1420430448 2094 dbSNP
rs768463345 2094 dbSNP
rs774001919 2094 dbSNP
rs9331424 2094 dbSNP
rs1490608924 2095 dbSNP
rs1291738930 2096 dbSNP
rs1219997978 2099 dbSNP
rs897841892 2104 dbSNP
rs1373182213 2108 dbSNP
rs1413794620 2110 dbSNP
rs1293677439 2111 dbSNP
rs7955441 2113 dbSNP
rs560814613 2114 dbSNP
rs1285372723 2120 dbSNP
rs1405377715 2126 dbSNP
rs949028908 2133 dbSNP
rs1308034846 2144 dbSNP
rs1415459997 2146 dbSNP
rs1205241439 2158 dbSNP
rs752405392 2164 dbSNP
rs1455298444 2183 dbSNP
rs1046519171 2193 dbSNP
rs928866176 2194 dbSNP
rs1295668954 2207 dbSNP
rs1398405576 2210 dbSNP
rs937590001 2215 dbSNP
rs779851732 2222 dbSNP
rs1199654683 2228 dbSNP
rs1481005810 2236 dbSNP
rs1268609412 2238 dbSNP
rs1189781729 2239 dbSNP
rs1487137871 2248 dbSNP
rs898683720 2254 dbSNP
rs146129957 2266 dbSNP
rs1215180320 2267 dbSNP
rs757548912 2269 dbSNP
rs887233566 2271 dbSNP
rs751304296 2273 dbSNP
rs181571125 2275 dbSNP
rs779265156 2281 dbSNP
rs1323030634 2284 dbSNP
rs1298929790 2291 dbSNP
rs562915920 2298 dbSNP
rs1383665174 2310 dbSNP
rs1362602848 2328 dbSNP
rs1185257141 2329 dbSNP
rs184900008 2365 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gauacccacccUGUCUCUCCc 5'
                     |:||||||| 
Target 5' ----------aAUAGAGAGGc 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000426426.1 | 3UTR | AAUAGAGAGGCUGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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