pre-miRNA Information
pre-miRNA hsa-mir-921   
Genomic Coordinates chr1: 166154743 - 166154798
Synonyms MIRN921, hsa-mir-921, MIR921
Description Homo sapiens miR-921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-921
Sequence 2| CUAGUGAGGGACAGAACCAGGAUUC |26
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31549221 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1464259216 3 dbSNP
rs768428855 8 dbSNP
rs746970999 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TAF13   
Synonyms MRT60, TAF(II)18, TAF2K, TAFII-18, TAFII18
Description TATA-box binding protein associated factor 13
Transcript NM_005645   
Expression
Putative miRNA Targets on TAF13
3'UTR of TAF13
(miRNA target sites are highlighted)
>TAF13|NM_005645|3'UTR
   1 CACTTTTTGTAGTTTCCGAAAATTACCATCTGGGGAAACCATATATAATAATTGTATATTTTCTAAAGTAAGATTCTGAT
  81 ATCTAGCCATGTAAATGAAAGATGGAGAAACACAAAGTTTTCAGCCTTTATTTTTATGCCTTTGATT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuaggaccAAGACAGGGAGUGAuc 5'
                   ||| | ||:|:|:|  
Target 5' cacaaagttTTCAG-CCTTTATTtt 3'
111 - 134 91.00 -9.30
2
miRNA  3' cuuaggaCCAAGAC-AGGGAGUGAUC- 5'
                 | ||||| | :|| :| |  
Target 5' aaagtaaGATTCTGATATCTAGCCATG 3'
65 - 91 74.00 -8.87
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30493607 21 COSMIC
COSN31498107 33 COSMIC
COSN30191578 35 COSMIC
COSN24398832 58 COSMIC
COSN30187931 76 COSMIC
COSN30119960 83 COSMIC
COSN30068199 91 COSMIC
COSN29263587 180 COSMIC
COSN22371248 379 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1051388965 1 dbSNP
rs1176113543 3 dbSNP
rs1468217786 7 dbSNP
rs997773389 9 dbSNP
rs765786346 13 dbSNP
rs759586910 17 dbSNP
rs201718167 18 dbSNP
rs1473336242 21 dbSNP
rs771099747 27 dbSNP
rs1213526359 28 dbSNP
rs1173844910 29 dbSNP
rs6604757 30 dbSNP
rs1182303082 33 dbSNP
rs1349211152 35 dbSNP
rs753210706 42 dbSNP
rs747252248 43 dbSNP
rs537495241 48 dbSNP
rs1466914938 53 dbSNP
rs1305092256 65 dbSNP
rs775041895 70 dbSNP
rs1377931018 71 dbSNP
rs1325465870 72 dbSNP
rs1439234712 73 dbSNP
rs522193 76 dbSNP
rs1053050597 78 dbSNP
rs191835272 89 dbSNP
rs925429729 94 dbSNP
rs955862030 96 dbSNP
rs1322523617 101 dbSNP
rs1233768740 104 dbSNP
rs1294669427 110 dbSNP
rs771567797 111 dbSNP
rs1479580158 115 dbSNP
rs1195173002 117 dbSNP
rs1251850101 136 dbSNP
rs1483769940 138 dbSNP
rs1196801567 140 dbSNP
rs187001365 147 dbSNP
rs111650544 150 dbSNP
rs948100755 151 dbSNP
rs917924528 153 dbSNP
rs992092277 159 dbSNP
rs1461867807 164 dbSNP
rs1309192917 166 dbSNP
rs960248601 169 dbSNP
rs1403224336 172 dbSNP
rs919206973 180 dbSNP
rs1368644882 183 dbSNP
rs968527466 184 dbSNP
rs1303064195 186 dbSNP
rs1305574969 191 dbSNP
rs1226554458 194 dbSNP
rs1275316745 195 dbSNP
rs1023119096 204 dbSNP
rs963278838 210 dbSNP
rs1267721625 211 dbSNP
rs1253364982 212 dbSNP
rs1192579805 213 dbSNP
rs553691876 217 dbSNP
rs143959539 220 dbSNP
rs565608824 228 dbSNP
rs1392621489 241 dbSNP
rs756524684 249 dbSNP
rs953072163 251 dbSNP
rs748393997 256 dbSNP
rs181478310 257 dbSNP
rs1438818423 263 dbSNP
rs7412176 263 dbSNP
rs755598484 270 dbSNP
rs1359567600 273 dbSNP
rs1303011274 276 dbSNP
rs569270520 279 dbSNP
rs1232328110 281 dbSNP
rs1434161334 283 dbSNP
rs1037188213 291 dbSNP
rs1006113917 311 dbSNP
rs1243683930 314 dbSNP
rs1302436970 317 dbSNP
rs1321813544 325 dbSNP
rs888575826 332 dbSNP
rs1258625913 334 dbSNP
rs1360498604 335 dbSNP
rs1485732779 336 dbSNP
rs1291139648 337 dbSNP
rs1410787325 340 dbSNP
rs1178355232 341 dbSNP
rs1050262080 342 dbSNP
rs1171410761 343 dbSNP
rs1436236637 344 dbSNP
rs1377782581 346 dbSNP
rs1443260698 347 dbSNP
rs1183540361 348 dbSNP
rs1192204544 348 dbSNP
rs1426509663 349 dbSNP
rs1263835607 355 dbSNP
rs1414573441 356 dbSNP
rs1194269462 358 dbSNP
rs1488681340 359 dbSNP
rs1279743194 362 dbSNP
rs1157162168 367 dbSNP
rs1229586367 367 dbSNP
rs1283561318 367 dbSNP
rs1304397704 367 dbSNP
rs1328134633 367 dbSNP
rs1344886448 367 dbSNP
rs1379226663 367 dbSNP
rs1390584075 367 dbSNP
rs1450301464 367 dbSNP
rs1456501101 367 dbSNP
rs1464741611 367 dbSNP
rs1488321988 367 dbSNP
rs35296800 367 dbSNP
rs71069642 367 dbSNP
rs1245360462 368 dbSNP
rs1468077059 368 dbSNP
rs138603694 369 dbSNP
rs1490421451 370 dbSNP
rs1333406217 372 dbSNP
rs1359731936 373 dbSNP
rs1449579358 379 dbSNP
rs1295880247 380 dbSNP
rs932678798 381 dbSNP
rs1349361088 382 dbSNP
rs1350342464 383 dbSNP
rs922560705 384 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000338366.5 | 3UTR | CUAUGUUGGCAGGCUGGAGUGCAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000338366.5 | 3UTR | CUAUGUUGGCAGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19783 ER+ ER+ breast cancer -0.687 4.1e-4 -0.734 1.1e-4 20 Click to see details
GSE28544 Breast cancer 0.498 6.6e-3 0.459 1.2e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.486 9.4e-3 -0.512 6.3e-3 23 Click to see details
GSE28260 Renal cortex and medulla -0.603 1.5e-2 -0.588 1.7e-2 13 Click to see details
GSE38226 Liver fibrosis 0.425 2.7e-2 0.463 1.7e-2 21 Click to see details
GSE21687 Ependynoma primary tumors -0.174 8.5e-2 -0.272 1.5e-2 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.219 1.5e-1 -0.194 1.8e-1 25 Click to see details
GSE19536 Breast cancer -0.103 1.5e-1 -0.197 2.5e-2 100 Click to see details
GSE19783 ER- ER- breast cancer 0.087 2.2e-1 -0.038 3.7e-1 79 Click to see details
GSE26953 Aortic valvular endothelial cells -0.161 2.3e-1 -0.141 2.6e-1 24 Click to see details
GSE19350 CNS germ cell tumors -0.213 2.5e-1 -0.126 3.5e-1 12 Click to see details
GSE32688 Pancreatic cancer -0.095 3.0e-1 -0.051 3.9e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.091 3.5e-1 0.029 4.5e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.091 3.5e-1 0.029 4.5e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.091 3.5e-1 0.029 4.5e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054764 ANGPTL1 angiopoietin like 1 3 1
MIRT066171 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT069409 ZFYVE21 zinc finger FYVE-type containing 21 2 8
MIRT102284 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 4
MIRT107595 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 6
MIRT178618 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT182407 TIPRL TOR signaling pathway regulator 2 4
MIRT186552 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT273662 HOXC8 homeobox C8 2 2
MIRT283191 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT284890 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT347670 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT400222 SLC35F6 solute carrier family 35 member F6 2 2
MIRT403517 ASPH aspartate beta-hydroxylase 2 2
MIRT442251 DCTN5 dynactin subunit 5 2 2
MIRT443023 SDR39U1 short chain dehydrogenase/reductase family 39U member 1 2 2
MIRT443097 RNF20 ring finger protein 20 2 2
MIRT444560 TRA2B transformer 2 beta homolog 2 2
MIRT445696 PRKG1 protein kinase, cGMP-dependent, type I 2 2
MIRT454084 TMEM209 transmembrane protein 209 2 2
MIRT455463 LYPLA2 lysophospholipase II 2 2
MIRT456653 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT458147 LYRM4 LYR motif containing 4 2 6
MIRT467073 SRRD SRR1 domain containing 2 4
MIRT467245 SPPL2A signal peptide peptidase like 2A 2 2
MIRT468246 SFXN4 sideroflexin 4 2 2
MIRT471589 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT476639 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT482433 ADM adrenomedullin 2 10
MIRT486848 PERP PERP, TP53 apoptosis effector 2 6
MIRT489656 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT493441 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT493841 FOXN3 forkhead box N3 2 4
MIRT501378 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT509679 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510280 MED28 mediator complex subunit 28 2 2
MIRT512221 ATXN3 ataxin 3 2 6
MIRT514030 BNIP2 BCL2 interacting protein 2 2 2
MIRT521375 RDX radixin 2 4
MIRT521444 RAD51 RAD51 recombinase 2 2
MIRT526055 CBR1 carbonyl reductase 1 2 2
MIRT528658 FUNDC2 FUN14 domain containing 2 2 2
MIRT529975 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT544098 IPMK inositol polyphosphate multikinase 2 2
MIRT545579 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT547424 MED4 mediator complex subunit 4 2 2
MIRT548955 CD2AP CD2 associated protein 2 2
MIRT549537 NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 2 4
MIRT552550 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554640 ROBO1 roundabout guidance receptor 1 2 2
MIRT564904 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT565578 SLC6A8 solute carrier family 6 member 8 2 2
MIRT568312 BAG4 BCL2 associated athanogene 4 2 2
MIRT617891 PTCHD3 patched domain containing 3 2 2
MIRT621892 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT642850 RNF135 ring finger protein 135 2 2
MIRT665395 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT697879 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT698492 THOC2 THO complex 2 2 2
MIRT701227 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT701872 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT707045 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT715216 NPVF neuropeptide VF precursor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-921 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miR-921 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-921 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-921 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-921 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-921 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-miR-921 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-921 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-921 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-921 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-921 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-921 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-921 Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-921 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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