pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SRPX2   
Synonyms BPP, CBPS, PMGX, RESDX, SRPUL
Description sushi repeat containing protein, X-linked 2
Transcript NM_014467   
Expression
Putative miRNA Targets on SRPX2
3'UTR of SRPX2
(miRNA target sites are highlighted)
>SRPX2|NM_014467|3'UTR
   1 ACTTGAGCCAGGGCATGGTTAAAGTCAAGGGAAAAGCTCCTCTAGTTAGCTGAAACTGGGACCTAATAAAAGGAGGAAAT
  81 GTTTTCCCACAGTTCTAGGGACAGGACTCTGAGGTGGGTGAGTTTGACAAATCCTGCAGTGTTTCCAGGCATCCTTTTAG
 161 GACTGTGTAATAGTTTCCCTAGAAGCTAGGTAGGGACTGAGGACAGGCCTTGGGCAGTGGGTTGGGGGTAGAAGTTCTTC
 241 CTTTCCTAACCCGGGCCCCTGCCCAGCTCTCCAAAGTCTTTCAGAAAAGTAAATCCTAAATTCAGTGATGAAAAAAAAAA
 321 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGUC--GGAGCGGGUCg 5'
            ||:|  || :|||||| 
Target 5' acCCGGGCCCCTGCCCAGc 3'
249 - 267 137.00 -22.40
2
miRNA  3' acgGUCGGAGCGGGUCg 5'
             :||::|| ||:|| 
Target 5' taaTAGTTTC-CCTAGa 3'
168 - 183 90.00 -13.60
3
miRNA  3' acggUCGGAGCGGGUCg 5'
              || ||| :|:|| 
Target 5' gaaaAG-CTCCTCTAGt 3'
31 - 46 88.00 -8.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1186773 61 ClinVar
rs8780 3549 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1407991482 4 dbSNP
rs1298333403 9 dbSNP
rs1339276255 12 dbSNP
rs1244141963 20 dbSNP
rs768382138 37 dbSNP
rs1398456688 40 dbSNP
rs750011322 46 dbSNP
rs748900381 51 dbSNP
rs148234042 61 dbSNP
rs1034060417 78 dbSNP
rs1479875815 80 dbSNP
rs1426804486 82 dbSNP
rs1326129929 100 dbSNP
rs192582647 101 dbSNP
rs745638769 103 dbSNP
rs996773558 109 dbSNP
rs1020767324 123 dbSNP
rs5967163 139 dbSNP
rs772053768 141 dbSNP
rs979205079 142 dbSNP
rs775264491 190 dbSNP
rs1323045367 192 dbSNP
rs1261547200 195 dbSNP
rs964952210 205 dbSNP
rs1225406899 215 dbSNP
rs1043400519 220 dbSNP
rs904458095 221 dbSNP
rs1440012054 253 dbSNP
rs1337445654 260 dbSNP
rs974469194 265 dbSNP
rs1211503805 276 dbSNP
rs1469067446 301 dbSNP
rs1403472602 306 dbSNP
rs746716442 312 dbSNP
rs933109306 314 dbSNP
rs1047502100 317 dbSNP
rs12838761 321 dbSNP
rs1406694480 327 dbSNP
rs1156291491 337 dbSNP
rs998607832 360 dbSNP
rs1235071364 362 dbSNP
rs1267977258 366 dbSNP
rs1461109357 367 dbSNP
rs1031485522 368 dbSNP
rs960087302 374 dbSNP
rs1312987678 382 dbSNP
rs775268108 391 dbSNP
rs1352793281 393 dbSNP
rs1451668058 401 dbSNP
rs5921621 407 dbSNP
rs1381752115 408 dbSNP
rs776159179 418 dbSNP
rs1338450485 426 dbSNP
rs1448377026 427 dbSNP
rs1344215883 436 dbSNP
rs1156364527 437 dbSNP
rs1401897271 444 dbSNP
rs1439960722 451 dbSNP
rs1159623237 452 dbSNP
rs113980158 455 dbSNP
rs1241707734 455 dbSNP
rs34012120 455 dbSNP
rs60709848 455 dbSNP
rs1368202921 457 dbSNP
rs1456720583 458 dbSNP
rs1213767795 464 dbSNP
rs1165470450 465 dbSNP
rs866308955 472 dbSNP
rs866821772 473 dbSNP
rs1446104747 474 dbSNP
rs1014786129 477 dbSNP
rs1316959436 491 dbSNP
rs1379392815 492 dbSNP
rs970494614 493 dbSNP
rs1360874384 499 dbSNP
rs1286705383 506 dbSNP
rs1432301964 513 dbSNP
rs1447867748 514 dbSNP
rs5921622 523 dbSNP
rs1319631023 530 dbSNP
rs1038510722 539 dbSNP
rs898753676 545 dbSNP
rs1002859065 546 dbSNP
rs1167395244 548 dbSNP
rs1424713897 552 dbSNP
rs1419094269 553 dbSNP
rs1055169425 570 dbSNP
rs1265903655 577 dbSNP
rs1338718454 584 dbSNP
rs973435037 588 dbSNP
rs896458151 593 dbSNP
rs1013652772 596 dbSNP
rs1489850639 597 dbSNP
rs1239531700 598 dbSNP
rs950961171 599 dbSNP
rs762067486 601 dbSNP
rs765538553 602 dbSNP
rs912091925 613 dbSNP
rs1340725852 614 dbSNP
rs373659417 616 dbSNP
rs1041232560 621 dbSNP
rs563234795 630 dbSNP
rs920931197 638 dbSNP
rs1000656986 640 dbSNP
rs1032583105 652 dbSNP
rs1253683826 660 dbSNP
rs932275850 662 dbSNP
rs1458740893 663 dbSNP
rs1354389575 669 dbSNP
rs113339718 674 dbSNP
rs1467425587 682 dbSNP
rs1167411474 687 dbSNP
rs1424567558 688 dbSNP
rs5921623 689 dbSNP
rs975048531 697 dbSNP
rs1269390216 698 dbSNP
rs922992671 699 dbSNP
rs1249458500 704 dbSNP
rs1206327705 719 dbSNP
rs763199971 727 dbSNP
rs1318196358 731 dbSNP
rs954375339 732 dbSNP
rs112046768 734 dbSNP
rs751964107 744 dbSNP
rs1052873067 747 dbSNP
rs907629602 750 dbSNP
rs112915821 759 dbSNP
rs1014340687 767 dbSNP
rs1023434929 783 dbSNP
rs1449409948 794 dbSNP
rs905947757 796 dbSNP
rs1175896090 799 dbSNP
rs1468301522 814 dbSNP
rs1379509953 815 dbSNP
rs1339748166 820 dbSNP
rs995221309 823 dbSNP
rs1259921642 841 dbSNP
rs777199072 869 dbSNP
rs1248283837 873 dbSNP
rs753361813 877 dbSNP
rs950930538 878 dbSNP
rs983726936 881 dbSNP
rs920083996 898 dbSNP
rs1253862288 900 dbSNP
rs1484053177 908 dbSNP
rs938298556 918 dbSNP
rs1019120544 927 dbSNP
rs1257373528 930 dbSNP
rs1055770917 931 dbSNP
rs12843988 937 dbSNP
rs1316876674 943 dbSNP
rs1305428093 949 dbSNP
rs966645357 966 dbSNP
rs182651219 970 dbSNP
rs1477705715 971 dbSNP
rs896706269 974 dbSNP
rs1192043318 975 dbSNP
rs974947511 984 dbSNP
rs1426444084 985 dbSNP
rs1450797567 991 dbSNP
rs1478158556 992 dbSNP
rs1303534501 996 dbSNP
rs949405580 1000 dbSNP
rs1042330423 1003 dbSNP
rs34754176 1021 dbSNP
rs759870989 1027 dbSNP
rs1467832652 1028 dbSNP
rs902639816 1029 dbSNP
rs1440234662 1038 dbSNP
rs767905601 1041 dbSNP
rs60519930 1055 dbSNP
rs1181504232 1060 dbSNP
rs34293399 1064 dbSNP
rs372122787 1064 dbSNP
rs73636612 1072 dbSNP
rs1204059237 1080 dbSNP
rs900320846 1090 dbSNP
rs1484574491 1095 dbSNP
rs771715312 1097 dbSNP
rs995996190 1110 dbSNP
rs1284508156 1115 dbSNP
rs1243036464 1125 dbSNP
rs187705133 1128 dbSNP
rs753031060 1132 dbSNP
rs530548432 1135 dbSNP
rs1342514703 1142 dbSNP
rs1313642256 1146 dbSNP
rs1381730873 1153 dbSNP
rs746875543 1161 dbSNP
rs1300104703 1168 dbSNP
rs768725389 1175 dbSNP
rs983126043 1190 dbSNP
rs1014588072 1201 dbSNP
rs1218102666 1223 dbSNP
rs1364856297 1230 dbSNP
rs963161206 1236 dbSNP
rs925651872 1245 dbSNP
rs1368699176 1250 dbSNP
rs1191941801 1274 dbSNP
rs1426362244 1287 dbSNP
rs1313578372 1291 dbSNP
rs1264775246 1298 dbSNP
rs934562877 1300 dbSNP
rs1488925084 1301 dbSNP
rs1291634162 1321 dbSNP
rs1208451347 1345 dbSNP
rs1358834393 1348 dbSNP
rs1285155909 1349 dbSNP
rs973541815 1351 dbSNP
rs776764245 1352 dbSNP
rs920134212 1363 dbSNP
rs1400650513 1369 dbSNP
rs895742475 1387 dbSNP
rs1442713940 1392 dbSNP
rs938190044 1396 dbSNP
rs761975702 1402 dbSNP
rs1044253451 1422 dbSNP
rs1265942720 1426 dbSNP
rs905912892 1428 dbSNP
rs1190679095 1434 dbSNP
rs796354690 1460 dbSNP
rs1425285851 1462 dbSNP
rs1193787162 1463 dbSNP
rs1479794008 1464 dbSNP
rs1268808264 1465 dbSNP
rs1197460892 1466 dbSNP
rs1423222839 1470 dbSNP
rs1453823468 1482 dbSNP
rs1291104079 1483 dbSNP
rs918170448 1484 dbSNP
rs994957705 1488 dbSNP
rs1434991694 1523 dbSNP
rs1177010757 1529 dbSNP
rs767643810 1536 dbSNP
rs1027637255 1551 dbSNP
rs769953746 1567 dbSNP
rs192552346 1570 dbSNP
rs1438594824 1573 dbSNP
rs1331585696 1584 dbSNP
rs1327978079 1591 dbSNP
rs184497464 1593 dbSNP
rs1402043883 1597 dbSNP
rs902504339 1609 dbSNP
rs936787607 1613 dbSNP
rs966322347 1617 dbSNP
rs1426673281 1620 dbSNP
rs975293040 1625 dbSNP
rs1479315190 1634 dbSNP
rs1054294460 1649 dbSNP
rs1247761557 1653 dbSNP
rs900562051 1656 dbSNP
rs565859290 1657 dbSNP
rs996417118 1659 dbSNP
rs1199580108 1661 dbSNP
rs953917338 1664 dbSNP
rs978506806 1671 dbSNP
rs189260034 1682 dbSNP
rs925620734 1698 dbSNP
rs1278830190 1718 dbSNP
rs774786745 1722 dbSNP
rs144260939 1727 dbSNP
rs753891040 1737 dbSNP
rs372465742 1759 dbSNP
rs1331776986 1767 dbSNP
rs955742616 1769 dbSNP
rs1357045041 1773 dbSNP
rs988437133 1776 dbSNP
rs192644961 1826 dbSNP
rs1426502899 1834 dbSNP
rs1158431728 1839 dbSNP
rs1438375754 1846 dbSNP
rs1382611209 1850 dbSNP
rs1179625765 1865 dbSNP
rs1461069879 1867 dbSNP
rs1014620496 1872 dbSNP
rs1245516840 1879 dbSNP
rs764825390 1881 dbSNP
rs917129177 1883 dbSNP
rs757480017 1900 dbSNP
rs750002163 1901 dbSNP
rs1489478361 1908 dbSNP
rs1214436684 1919 dbSNP
rs1355742511 1929 dbSNP
rs950009608 1944 dbSNP
rs1191896867 1950 dbSNP
rs1244927533 1957 dbSNP
rs1376546758 1958 dbSNP
rs1285531846 1963 dbSNP
rs1448129573 1967 dbSNP
rs973063288 1970 dbSNP
rs1034531702 1982 dbSNP
rs758072226 1984 dbSNP
rs1044607099 1989 dbSNP
rs991403806 1991 dbSNP
rs185033020 2003 dbSNP
rs746785448 2004 dbSNP
rs754882592 2006 dbSNP
rs930718921 2014 dbSNP
rs1049209314 2016 dbSNP
rs886531265 2028 dbSNP
rs781240465 2032 dbSNP
rs1436542296 2034 dbSNP
rs1221483893 2037 dbSNP
rs748149049 2041 dbSNP
rs1330139729 2042 dbSNP
rs1004848701 2061 dbSNP
rs924167859 2064 dbSNP
rs902068724 2077 dbSNP
rs7883527 2082 dbSNP
rs1275801066 2089 dbSNP
rs1053755401 2102 dbSNP
rs1401258443 2122 dbSNP
rs996464109 2132 dbSNP
rs922020305 2152 dbSNP
rs932079602 2167 dbSNP
rs750436027 2168 dbSNP
rs890273505 2176 dbSNP
rs1004830700 2184 dbSNP
rs189652531 2192 dbSNP
rs1036292997 2197 dbSNP
rs999897406 2213 dbSNP
rs376970679 2234 dbSNP
rs1263819475 2237 dbSNP
rs1198691750 2238 dbSNP
rs796855288 2244 dbSNP
rs1487457998 2260 dbSNP
rs955805570 2270 dbSNP
rs1221988929 2276 dbSNP
rs994912682 2285 dbSNP
rs1255704098 2287 dbSNP
rs1033984951 2296 dbSNP
rs1317912625 2297 dbSNP
rs758240769 2307 dbSNP
rs180780022 2359 dbSNP
rs1025128495 2371 dbSNP
rs142984997 2380 dbSNP
rs927117258 2386 dbSNP
rs930423701 2387 dbSNP
rs1405949944 2391 dbSNP
rs978207984 2397 dbSNP
rs907930811 2405 dbSNP
rs1169325092 2410 dbSNP
rs1467377468 2427 dbSNP
rs1424497603 2431 dbSNP
rs1175420167 2441 dbSNP
rs1431406212 2469 dbSNP
rs940773125 2485 dbSNP
rs1191579830 2486 dbSNP
rs924199126 2489 dbSNP
rs901870545 2493 dbSNP
rs1200211487 2503 dbSNP
rs111684083 2509 dbSNP
rs1262012048 2510 dbSNP
rs1230388780 2516 dbSNP
rs1310983990 2521 dbSNP
rs1303984159 2525 dbSNP
rs1050736719 2530 dbSNP
rs1329713444 2532 dbSNP
rs1447721393 2566 dbSNP
rs774616590 2571 dbSNP
rs1449344859 2574 dbSNP
rs1401261967 2582 dbSNP
rs1302366430 2583 dbSNP
rs1282864355 2589 dbSNP
rs1464566341 2589 dbSNP
rs759891077 2589 dbSNP
rs767909979 2593 dbSNP
rs1176615247 2602 dbSNP
rs1438998160 2614 dbSNP
rs775927233 2618 dbSNP
rs185985074 2631 dbSNP
rs1439957515 2634 dbSNP
rs1254992867 2648 dbSNP
rs932080044 2650 dbSNP
rs1198249404 2653 dbSNP
rs1483908672 2665 dbSNP
rs1316105395 2679 dbSNP
rs764582452 2687 dbSNP
rs1031149348 2688 dbSNP
rs955773092 2694 dbSNP
rs749962324 2695 dbSNP
rs375784639 2697 dbSNP
rs1200623616 2698 dbSNP
rs370994231 2711 dbSNP
rs1382048258 2745 dbSNP
rs911948668 2757 dbSNP
rs1009971918 2761 dbSNP
rs940522274 2762 dbSNP
rs1036157795 2763 dbSNP
rs1377954119 2764 dbSNP
rs1024384950 2780 dbSNP
rs971127208 2790 dbSNP
rs1442096801 2794 dbSNP
rs899085566 2803 dbSNP
rs1303483969 2811 dbSNP
rs980178788 2827 dbSNP
rs994756839 2830 dbSNP
rs951955042 2831 dbSNP
rs1420027379 2842 dbSNP
rs1055891726 2846 dbSNP
rs1425173213 2859 dbSNP
rs1475420266 2859 dbSNP
rs35533258 2860 dbSNP
rs766047940 2867 dbSNP
rs1192266591 2878 dbSNP
rs984598480 2880 dbSNP
rs751295106 2882 dbSNP
rs1478505305 2885 dbSNP
rs894129092 2890 dbSNP
rs1219262580 2891 dbSNP
rs754794669 2893 dbSNP
rs940740659 2914 dbSNP
rs781159571 2917 dbSNP
rs1265218665 2918 dbSNP
rs1242955862 2926 dbSNP
rs1168034002 2931 dbSNP
rs1013847512 2942 dbSNP
rs1342459925 2947 dbSNP
rs151110075 2951 dbSNP
rs1399431708 2953 dbSNP
rs1412460204 2958 dbSNP
rs1299892326 2962 dbSNP
rs1335800148 2964 dbSNP
rs4828040 2966 dbSNP
rs1161220851 2968 dbSNP
rs1415817743 2975 dbSNP
rs976225586 2990 dbSNP
rs1169366085 3008 dbSNP
rs1476520911 3046 dbSNP
rs749375246 3049 dbSNP
rs777660643 3049 dbSNP
rs1448065863 3070 dbSNP
rs1267159777 3074 dbSNP
rs999658949 3086 dbSNP
rs1339154799 3087 dbSNP
rs757101267 3087 dbSNP
rs144977235 3088 dbSNP
rs931960040 3098 dbSNP
rs958573794 3099 dbSNP
rs774526894 3119 dbSNP
rs1270910670 3123 dbSNP
rs1344561995 3137 dbSNP
rs989727738 3144 dbSNP
rs1281000200 3146 dbSNP
rs768299432 3161 dbSNP
rs536662984 3167 dbSNP
rs1485852543 3175 dbSNP
rs1215691767 3177 dbSNP
rs138910057 3179 dbSNP
rs1489269224 3185 dbSNP
rs936950653 3190 dbSNP
rs780772230 3197 dbSNP
rs987443974 3225 dbSNP
rs1376522368 3237 dbSNP
rs1391019370 3251 dbSNP
rs911981964 3253 dbSNP
rs867813978 3270 dbSNP
rs189280940 3276 dbSNP
rs1463730656 3292 dbSNP
rs940720928 3295 dbSNP
rs971924761 3306 dbSNP
rs920438445 3314 dbSNP
rs1395333611 3323 dbSNP
rs1197221701 3324 dbSNP
rs930584654 3345 dbSNP
rs747677450 3350 dbSNP
rs1298011054 3352 dbSNP
rs1456593658 3379 dbSNP
rs775837398 3385 dbSNP
rs1215200899 3390 dbSNP
rs769339179 3397 dbSNP
rs1045337660 3400 dbSNP
rs1034448254 3417 dbSNP
rs1330526566 3443 dbSNP
rs1308236102 3463 dbSNP
rs1231198204 3474 dbSNP
rs902973275 3480 dbSNP
rs372612073 3495 dbSNP
rs1331475007 3499 dbSNP
rs1413352442 3500 dbSNP
rs182020954 3501 dbSNP
rs998557128 3503 dbSNP
rs140612294 3504 dbSNP
rs777068334 3513 dbSNP
rs1011465222 3542 dbSNP
rs1178379593 3546 dbSNP
rs1355602309 3546 dbSNP
rs1205581354 3548 dbSNP
rs8780 3549 dbSNP
rs953719639 3560 dbSNP
rs987478213 3582 dbSNP
rs1202159389 3592 dbSNP
rs1348475516 3599 dbSNP
rs1308311194 3600 dbSNP
rs1237640266 3602 dbSNP
rs976321167 3622 dbSNP
rs185769832 3654 dbSNP
rs190632064 3655 dbSNP
rs1438763312 3660 dbSNP
rs752553478 3664 dbSNP
rs1335600069 3675 dbSNP
rs1378791952 3678 dbSNP
rs932079967 3686 dbSNP
rs1376556766 3699 dbSNP
rs1455678580 3700 dbSNP
rs986132688 3701 dbSNP
rs972129423 3708 dbSNP
rs920646808 3716 dbSNP
rs1178059497 3721 dbSNP
rs1472582098 3732 dbSNP
rs1390672366 3745 dbSNP
rs755921711 3748 dbSNP
rs1235855179 3772 dbSNP
rs775864729 3782 dbSNP
rs991691291 3783 dbSNP
rs936918158 3792 dbSNP
rs1052675845 3793 dbSNP
rs1214184794 3798 dbSNP
rs1371985183 3806 dbSNP
rs1355673358 3812 dbSNP
rs1284679423 3815 dbSNP
rs183497469 3822 dbSNP
rs1353787101 3837 dbSNP
rs1285483586 3841 dbSNP
rs1414817782 3858 dbSNP
rs1356676686 3862 dbSNP
rs1307358339 3877 dbSNP
rs915837585 3893 dbSNP
rs1398686905 3899 dbSNP
rs1347371669 3915 dbSNP
rs1378790840 3933 dbSNP
rs1160255338 3944 dbSNP
rs1239534276 3946 dbSNP
rs949961742 3948 dbSNP
rs1405030088 3949 dbSNP
rs1045411267 3965 dbSNP
rs902836096 3969 dbSNP
rs1475538971 3983 dbSNP
rs1262564382 3985 dbSNP
rs1191494034 3993 dbSNP
rs1489217831 3995 dbSNP
rs934442116 4009 dbSNP
rs1354209213 4032 dbSNP
rs1211102028 4037 dbSNP
rs1242534534 4042 dbSNP
rs1220509681 4043 dbSNP
rs1054226731 4046 dbSNP
rs1291513778 4047 dbSNP
rs1233366402 4050 dbSNP
rs1316828991 4084 dbSNP
rs1273329155 4098 dbSNP
rs186394828 4102 dbSNP
rs1011078742 4103 dbSNP
rs1176324996 4104 dbSNP
rs757339687 4111 dbSNP
rs1348369912 4112 dbSNP
rs778994011 4133 dbSNP
rs1462152517 4136 dbSNP
rs1029542699 4148 dbSNP
rs1168584633 4150 dbSNP
rs1421199086 4151 dbSNP
rs1420086941 4162 dbSNP
rs889405835 4166 dbSNP
rs906927248 4167 dbSNP
rs1248233982 4181 dbSNP
rs1213991953 4185 dbSNP
rs1457020519 4197 dbSNP
rs138601724 4199 dbSNP
rs1199938808 4201 dbSNP
rs772295113 4218 dbSNP
rs962051532 4221 dbSNP
rs1296847624 4235 dbSNP
rs972450301 4238 dbSNP
rs1027740659 4247 dbSNP
rs780311378 4251 dbSNP
rs1219156066 4257 dbSNP
rs1456894507 4262 dbSNP
rs1306055677 4266 dbSNP
rs1441968988 4267 dbSNP
rs952192357 4278 dbSNP
rs1329424813 4295 dbSNP
rs1463541968 4300 dbSNP
rs747391721 4302 dbSNP
rs768937564 4303 dbSNP
rs760950494 4304 dbSNP
rs1431353260 4343 dbSNP
rs1396708287 4347 dbSNP
rs1465199329 4351 dbSNP
rs1193989116 4359 dbSNP
rs1329508278 4361 dbSNP
rs1438728945 4368 dbSNP
rs1199997583 4385 dbSNP
rs191190551 4413 dbSNP
rs1034002190 4420 dbSNP
rs915725251 4426 dbSNP
rs971309841 4429 dbSNP
rs1235425579 4448 dbSNP
rs1376460773 4449 dbSNP
rs1307271359 4452 dbSNP
rs1393359843 4457 dbSNP
rs762246741 4466 dbSNP
rs41310707 4499 dbSNP
rs1464514217 4523 dbSNP
rs1338610064 4524 dbSNP
rs1246824018 4528 dbSNP
rs774004760 4532 dbSNP
rs1418801595 4536 dbSNP
rs1006137743 4547 dbSNP
rs924504623 4548 dbSNP
rs1419282934 4552 dbSNP
rs1316702829 4557 dbSNP
rs934348560 4559 dbSNP
rs1259562682 4576 dbSNP
rs759211133 4582 dbSNP
rs914336509 4585 dbSNP
rs767268332 4586 dbSNP
rs754066518 4592 dbSNP
rs1050656235 4597 dbSNP
rs889270170 4599 dbSNP
rs1212053635 4605 dbSNP
rs1353526880 4637 dbSNP
rs1284303992 4638 dbSNP
rs1241504682 4642 dbSNP
rs7063127 4650 dbSNP
rs370671348 4651 dbSNP
rs898040015 4681 dbSNP
rs1422439761 4689 dbSNP
rs1190650601 4691 dbSNP
rs1313339181 4694 dbSNP
rs993520169 4699 dbSNP
rs1358443770 4704 dbSNP
rs986655411 4710 dbSNP
rs1419242137 4715 dbSNP
rs1454021818 4730 dbSNP
rs1477525375 4732 dbSNP
rs1168675008 4735 dbSNP
rs760488435 4740 dbSNP
rs1462737180 4742 dbSNP
rs796241020 4756 dbSNP
rs952200357 4768 dbSNP
rs763845887 4772 dbSNP
rs1189346766 4779 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggucGGA-GCGGGUCg 5'
                |:| ||||||| 
Target 5' ------CUUGCGCCCAGg 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000373004.3 | 3UTR | CUUGCGCCCAGGCUGGAGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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