miRTarBase - #MIRT622147


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pre-miRNA Information
pre-miRNA hsa-mir-3152   
Genomic Coordinates chr9: 18573306 - 18573379
Description Homo sapiens miR-3152 stem-loop
Comment Berezikov et al. proposed this sequence as a miRNA candidate based on the RAKE method .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3152-5p
Sequence 11| AUUGCCUCUGUUCUAACACAAG |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1019691326 2 dbSNP
rs1282676806 8 dbSNP
rs762305650 11 dbSNP
rs1364318615 12 dbSNP
rs556364307 18 dbSNP
rs1002755159 19 dbSNP
rs1238555909 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SORBS2   
Synonyms ARGBP2, PRO0618
Description sorbin and SH3 domain containing 2
Transcript NM_001145670   
Other Transcripts NM_001145671 , NM_001145672 , NM_001145673 , NM_001145674 , NM_001145675 , NM_003603 , NM_021069   
Expression
Putative miRNA Targets on SORBS2
3'UTR of SORBS2
(miRNA target sites are highlighted)		 
>SORBS2|NM_001145670|3'UTR
   1 ATTGCGCTCCCTCCTTCTGTAGAGGCCGCCTGCCAGCCATGCACCTGCGTCAACGCGCCTGAAACACCCCGCGGGCCTCC
  81 CGTTGTCATGCCTTACGGTTTCCAATGCGCCGTCACCATCTCCACCTGCCACCAAACCACCAGCAGAGTAGCCGCCGCTG
 161 CTGTGAGCCTGGGGACGACATGGCAGGCTGGTCCCCCTCCGTGAAAGTGTGGATTCCTACTTCCTGCTCTAAGCTTTGAC
 241 ACGTCAAAATGTGGGATCAGAAAGAAAAAAATCATGATATTTAAAAATGGTCAAATATTTGAGGCAAAAAAAAAAAAAAA
 321 AAGTGTCTCCAGGAGGCTGTCCAGCCTCGTGGCTCCATTTCAACATCTCCCCCCAGGCGATGTTCTCCCCCAAGACGACC
 401 AGAAAATTGTTTATTGGGGAATGCTGTGGTTTGCATTTTCATATTCTTCGCTTGGCAGTGTGTATTCTTTTCACAAGTTT
 481 GCCTAGTGTCTTGGTTTACACAATATGACAACTGTAACTGTACTTTAGCTATTGTTTGCCTGCACATACATGTTGTAATA
 561 TGCACAGTGATTACAACCTTTAAAGCAAGAGGAGGCGAGTTAATTTGGATGAGTGTGATTTTGCTGATTGAATGTGAGTT
 641 TTCAAATAGGAGTCTTTTTCTGCAATTTGTTTGCATTTTTTAGAAGTGCAAACAGTAAGTAAATAAAAGCCTTCGGTAAT
 721 AATCATGACAATACAAGAGGCTGAGCTAGGCTACAGGGGAAAACTATTGTGTTGTAAAGTTGCATCGCTATTTTATATTA
 801 AAATGTAATGATCAGCATCATGAACAATGAGCTCTTAGTGTTTTATTTATCTGAAAAAATGTAAGTAAAAGCAGTGTTAG
 881 TGAGAGGTGCAAAGAATTATTCTAACAGACACCTGAAAGTATCTGTAAGCAATACTAGTAGGTAAGATTTCACTGTGTGT
 961 ACACATACACATTTGAGATTGTATGAGAACATATAATCCATATGATATGTTGTACATTTTATGGAAATGTAATAGAATCT
1041 CACACATTATTTTATAGAAATAGAGTACAGAAGCATCACAAGTATTAAAGTTGGTTTTAGCAAGGATTAGGATTACTACA
1121 ATTATTTTTACTATAATAATTATTTTTCTTCTATGGAACTCAGAATCCTGGCTACATTTGAGGACAGGAATATGTTGAGC
1201 CTGATTTTCCTGGTGTGTGTAAAATATTTCCTAGGAATAAATTAGGCACTTTTTAGAAGCAATGTTAAATCATTCAGGTT
1281 TTATTTTCTGCCCTGAAGCAGAAATTTAAAAAATGATATTGGGACCTGGAAGGTTTAATATGGTTCACAGTGCCTGAATT
1361 ACACCTGCTCCGAAAACTAGCTTTGTATTTCTTATGACTTTGCATAAGAACTGTTCATCTTTGGATCTTGAGCACCTTAC
1441 AGATAAAACTTTTTATGGCATCTCTTTCATGGACAGTGATATTGATCTTTTCACAATGTACGTAGCCTCTAGAATTTTGT
1521 ACATATGTTTGCTCTTTTTTTGTACAGACTAGTTGTTGAGAAAACAGGGGCGTTTCCTAATTTGGTCTTTATCCTGCGAC
1601 AACACTTTCAGCAGACTAGCCTCTCCTTATCTCACAGATCACAAGCACCCCTAGATAGTGTGATTCTGTCAGATAGCATT
1681 TATGCAAAAATCTATGAAGTTAAAAGATCGTAGAAGCCAAATGAAATGTACATATCTACTGACTGATGACAAGGGAATTT
1761 CATTAGGAAGAAGGTAAAGAAACATCGTTGAGTAGCCTACCTTGATTTCTGTCAAGTTCATAACCAGCTTCATATTTTAA
1841 AGGCTTCAGGTTTGAAATTAAGTCAACTGCATGCAGCTTTGCTGATAAATGAATAATTCTCTTTGATGCCATTTATGAGA
1921 AAAGACTTCAATATCTGTTGCCTGTCATATTTAAGAAAAATTACTGTTTCTACTCTCTGTATCTGATTTTAAAAGAAAAA
2001 ACTATTCATACCTGGCTTCCAGGTAATTGACTTTGAATTCTTACAAGCAAAGGTCATTGTGTTTTTCTTGAATAGACATC
2081 TAATAAATTTTGCTTGGAAGTATACTTCAGTTTTTCTTCTTGACATTTATCTTTATAAAAATTGTGTATTTTATTCCAAC
2161 TTGTTAAACTAAGAGAAAATGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaacACAAUCUUGU---CUCCGUUa 5'
              || |  ||:|   ||||||| 
Target 5' aaaaTGGTCAAATATTTGAGGCAAa 3'
 284 - 308 150.00 -8.17
2 
miRNA  3' gaacacAAUCUUGU----CUCCGUUa 5'
                ||| |:||    |||||:| 
Target 5' caacctTTAAAGCAAGAGGAGGCGAg 3'
 574 - 599 138.00 -10.60
3 
miRNA  3' gaaCACAAUCUUGUCUC--CGUUa 5'
             ||||||| : ||||  |||| 
Target 5' gcaGTGTTAGTG-AGAGGTGCAAa 3'
 871 - 893 130.00 -15.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN23587664 5 COSMIC
COSN30517865 17 COSMIC
COSN30500258 27 COSMIC
COSN30505961 35 COSMIC
COSN26996342 49 COSMIC
COSN30140181 56 COSMIC
COSN31494061 57 COSMIC
COSN167381 58 COSMIC
COSN30584798 96 COSMIC
COSN30134388 97 COSMIC
COSN26509043 102 COSMIC
COSN31552845 108 COSMIC
COSN31560197 154 COSMIC
COSN6819742 176 COSMIC
COSN30167219 180 COSMIC
COSN27497145 305 COSMIC
COSN27938605 423 COSMIC
COSN15112733 447 COSMIC
COSN24300495 456 COSMIC
COSN31555849 496 COSMIC
COSN31596939 523 COSMIC
COSN25230100 702 COSMIC
COSN26634831 805 COSMIC
COSN24907088 854 COSMIC
COSN31550778 956 COSMIC
COSN31603246 976 COSMIC
COSN6819741 1008 COSMIC
COSN31585639 1015 COSMIC
COSN28201163 1164 COSMIC
COSN20579995 1180 COSMIC
COSN31566593 1224 COSMIC
COSN31563704 1354 COSMIC
COSN26553399 1365 COSMIC
COSN28652908 1372 COSMIC
COSN26641876 1381 COSMIC
COSN30164958 1403 COSMIC
COSN19657944 1420 COSMIC
COSN5057576 1428 COSMIC
COSN25885881 1468 COSMIC
COSN20100885 1479 COSMIC
COSN20100879 1549 COSMIC
COSN31556229 1572 COSMIC
COSN6819740 1994 COSMIC
COSN21090214 2097 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746512203 4 dbSNP
rs1353315274 5 dbSNP
rs1290657961 6 dbSNP
rs1282313596 7 dbSNP
rs1189140598 9 dbSNP
rs368407144 18 dbSNP
rs1448999845 19 dbSNP
rs908908606 19 dbSNP
rs771720037 20 dbSNP
rs1416280695 25 dbSNP
rs746277485 28 dbSNP
rs1413878938 29 dbSNP
rs779270613 30 dbSNP
rs942503677 32 dbSNP
rs1417446547 34 dbSNP
rs199545440 37 dbSNP
rs1164846950 40 dbSNP
rs1406665167 41 dbSNP
rs754345608 42 dbSNP
rs1164848130 44 dbSNP
rs1478323603 46 dbSNP
rs778196728 49 dbSNP
rs375252999 50 dbSNP
rs1485659996 51 dbSNP
rs1379377835 54 dbSNP
rs1227394316 56 dbSNP
rs981173479 57 dbSNP
rs3186 58 dbSNP
rs566645742 59 dbSNP
rs1485351520 68 dbSNP
rs972331787 71 dbSNP
rs1267477179 72 dbSNP
rs546495776 74 dbSNP
rs1186707258 75 dbSNP
rs917455168 82 dbSNP
rs1347902917 87 dbSNP
rs1302052092 89 dbSNP
rs527761093 90 dbSNP
rs1412062362 92 dbSNP
rs1022787441 100 dbSNP
rs1160516083 105 dbSNP
rs1388501412 108 dbSNP
rs562042801 109 dbSNP
rs139388877 111 dbSNP
rs1328097843 119 dbSNP
rs1012814818 120 dbSNP
rs1446827887 122 dbSNP
rs951553196 124 dbSNP
rs958880617 125 dbSNP
rs893036712 129 dbSNP
rs999937149 136 dbSNP
rs1228819765 142 dbSNP
rs1381394682 152 dbSNP
rs1032866787 156 dbSNP
rs531586264 168 dbSNP
rs1202112523 173 dbSNP
rs1280823947 174 dbSNP
rs968815057 176 dbSNP
rs1255727060 179 dbSNP
rs562587192 183 dbSNP
rs1183291527 190 dbSNP
rs1296516444 193 dbSNP
rs903158456 194 dbSNP
rs1376210409 198 dbSNP
rs1051619930 199 dbSNP
rs1425237276 201 dbSNP
rs1413458506 202 dbSNP
rs901105665 213 dbSNP
rs1040901637 215 dbSNP
rs1006696476 220 dbSNP
rs1307108774 221 dbSNP
rs1348471846 227 dbSNP
rs12647793 229 dbSNP
rs1235312114 233 dbSNP
rs567989021 242 dbSNP
rs934087814 243 dbSNP
rs900033964 254 dbSNP
rs1465023648 257 dbSNP
rs1375235184 258 dbSNP
rs1194381984 260 dbSNP
rs1428223049 264 dbSNP
rs1345775007 271 dbSNP
rs1260611823 272 dbSNP
rs889598974 275 dbSNP
rs1484128101 277 dbSNP
rs1254116812 279 dbSNP
rs1206139471 289 dbSNP
rs376263897 291 dbSNP
rs568344592 291 dbSNP
rs1436487599 295 dbSNP
rs1189704322 301 dbSNP
rs1485794339 302 dbSNP
rs538533271 303 dbSNP
rs1198209117 304 dbSNP
rs1341417020 305 dbSNP
rs781140080 306 dbSNP
rs1167640489 323 dbSNP
rs1229391369 323 dbSNP
rs1368447763 323 dbSNP
rs1391495301 323 dbSNP
rs1404746125 323 dbSNP
rs1429997181 323 dbSNP
rs33934418 323 dbSNP
rs397879746 323 dbSNP
rs878910688 323 dbSNP
rs879032692 323 dbSNP
rs1039861794 327 dbSNP
rs1337817624 339 dbSNP
rs1226435931 340 dbSNP
rs1338220361 343 dbSNP
rs1268521771 348 dbSNP
rs1451480754 349 dbSNP
rs920630369 362 dbSNP
rs1036354742 364 dbSNP
rs546065733 365 dbSNP
rs1449596526 369 dbSNP
rs374364804 370 dbSNP
rs941620152 372 dbSNP
rs1459145489 373 dbSNP
rs910156208 374 dbSNP
rs1163569241 375 dbSNP
rs1356309573 375 dbSNP
rs1403527436 379 dbSNP
rs983005016 380 dbSNP
rs1322531948 387 dbSNP
rs940635205 390 dbSNP
rs1297001839 397 dbSNP
rs35223292 397 dbSNP
rs1324858447 407 dbSNP
rs928957095 409 dbSNP
rs768288755 419 dbSNP
rs981629653 432 dbSNP
rs1247275318 433 dbSNP
rs1266335148 434 dbSNP
rs569573157 444 dbSNP
rs1465772192 449 dbSNP
rs1399263123 450 dbSNP
rs1207502831 460 dbSNP
rs1259076933 465 dbSNP
rs1023243585 470 dbSNP
rs1168941765 472 dbSNP
rs560702274 485 dbSNP
rs1367659127 488 dbSNP
rs1422015523 493 dbSNP
rs1161242915 501 dbSNP
rs1389235365 514 dbSNP
rs1456659965 516 dbSNP
rs188077981 516 dbSNP
rs927467437 526 dbSNP
rs978958878 539 dbSNP
rs150915458 541 dbSNP
rs1475361289 550 dbSNP
rs112407842 553 dbSNP
rs998691242 558 dbSNP
rs779912833 566 dbSNP
rs1184823308 567 dbSNP
rs903223178 569 dbSNP
rs1029656711 578 dbSNP
rs554032309 579 dbSNP
rs1315949515 582 dbSNP
rs1274866968 586 dbSNP
rs556153458 587 dbSNP
rs899898324 595 dbSNP
rs1184018109 605 dbSNP
rs1039788609 619 dbSNP
rs1412451294 625 dbSNP
rs1472185411 626 dbSNP
rs1362113109 628 dbSNP
rs141519219 634 dbSNP
rs889640849 636 dbSNP
rs1375025125 647 dbSNP
rs1413185883 653 dbSNP
rs1310172251 655 dbSNP
rs35627617 660 dbSNP
rs1233622990 676 dbSNP
rs1335765488 685 dbSNP
rs182557294 693 dbSNP
rs1305551874 695 dbSNP
rs995363698 695 dbSNP
rs770216346 703 dbSNP
rs769482975 705 dbSNP
rs1036407082 714 dbSNP
rs747373992 715 dbSNP
rs1482634806 719 dbSNP
rs895808749 720 dbSNP
rs544371158 725 dbSNP
rs189891480 726 dbSNP
rs1176813215 727 dbSNP
rs1394564749 728 dbSNP
rs1433091679 735 dbSNP
rs1416723975 742 dbSNP
rs918944888 755 dbSNP
rs1045384143 757 dbSNP
rs1441982972 775 dbSNP
rs1296837509 779 dbSNP
rs1370295010 785 dbSNP
rs1301978916 787 dbSNP
rs1345201644 789 dbSNP
rs1230142729 797 dbSNP
rs1274959450 799 dbSNP
rs1341062052 804 dbSNP
rs3172664 805 dbSNP
rs538892505 832 dbSNP
rs1488730009 834 dbSNP
rs1190614467 849 dbSNP
rs1180432040 851 dbSNP
rs1456403759 857 dbSNP
rs146330420 860 dbSNP
rs991163848 865 dbSNP
rs957204554 870 dbSNP
rs1390979141 879 dbSNP
rs566677636 879 dbSNP
rs965042618 881 dbSNP
rs1019220331 887 dbSNP
rs553087957 899 dbSNP
rs1325894293 902 dbSNP
rs1368111139 904 dbSNP
rs185129521 906 dbSNP
rs1297722770 908 dbSNP
rs1436593739 908 dbSNP
rs977342443 914 dbSNP
rs953978852 919 dbSNP
rs200699892 923 dbSNP
rs370618469 925 dbSNP
rs1467818863 945 dbSNP
rs1287455647 954 dbSNP
rs1226887818 955 dbSNP
rs1271245318 964 dbSNP
rs967308631 968 dbSNP
rs1210619763 969 dbSNP
rs758641702 978 dbSNP
rs1248740639 989 dbSNP
rs998217458 991 dbSNP
rs964362407 992 dbSNP
rs200851678 998 dbSNP
rs1416395781 1003 dbSNP
rs1424808405 1007 dbSNP
rs896965203 1017 dbSNP
rs1392857800 1033 dbSNP
rs1320560545 1034 dbSNP
rs1459295662 1034 dbSNP
rs1344156847 1042 dbSNP
rs1018382037 1045 dbSNP
rs1304273572 1046 dbSNP
rs1375374424 1050 dbSNP
rs567161037 1054 dbSNP
rs895861065 1055 dbSNP
rs888649891 1065 dbSNP
rs1349728136 1067 dbSNP
rs1057126336 1072 dbSNP
rs1228937352 1083 dbSNP
rs1285040806 1110 dbSNP
rs1446558328 1124 dbSNP
rs937306897 1136 dbSNP
rs1239391992 1143 dbSNP
rs1483713813 1145 dbSNP
rs1187607715 1151 dbSNP
rs1321948920 1157 dbSNP
rs1416147381 1160 dbSNP
rs1473854398 1163 dbSNP
rs1047246190 1177 dbSNP
rs1160624460 1180 dbSNP
rs1402130103 1187 dbSNP
rs1385165361 1188 dbSNP
rs906117969 1190 dbSNP
rs994848675 1206 dbSNP
rs548271860 1209 dbSNP
rs1043679538 1221 dbSNP
rs753276847 1227 dbSNP
rs1396825726 1233 dbSNP
rs1359334088 1235 dbSNP
rs376564255 1237 dbSNP
rs1310781124 1238 dbSNP
rs570534656 1244 dbSNP
rs1410348023 1256 dbSNP
rs1350007160 1260 dbSNP
rs1453721910 1260 dbSNP
rs913389134 1263 dbSNP
rs1280842930 1264 dbSNP
rs759389192 1282 dbSNP
rs1348785545 1284 dbSNP
rs1210516804 1285 dbSNP
rs1217651364 1288 dbSNP
rs6835962 1294 dbSNP
rs1285173449 1303 dbSNP
rs182085265 1308 dbSNP
rs1469076236 1314 dbSNP
rs753898903 1315 dbSNP
rs549602221 1317 dbSNP
rs985149575 1319 dbSNP
rs1055509280 1327 dbSNP
rs1425269441 1328 dbSNP
rs138981851 1332 dbSNP
rs531364562 1333 dbSNP
rs6831183 1342 dbSNP
rs1305712218 1347 dbSNP
rs1235717424 1354 dbSNP
rs1327963428 1358 dbSNP
rs1367485549 1362 dbSNP
rs560631538 1362 dbSNP
rs1273462375 1368 dbSNP
rs1433277134 1371 dbSNP
rs10031753 1372 dbSNP
rs977208676 1380 dbSNP
rs1278502841 1383 dbSNP
rs967594422 1392 dbSNP
rs868361480 1395 dbSNP
rs922558929 1402 dbSNP
rs977042264 1404 dbSNP
rs964114172 1412 dbSNP
rs749020402 1418 dbSNP
rs368964356 1421 dbSNP
rs750565714 1423 dbSNP
rs1173683385 1430 dbSNP
rs1413888984 1433 dbSNP
rs1422917028 1435 dbSNP
rs1005006046 1436 dbSNP
rs1453321749 1437 dbSNP
rs530229853 1454 dbSNP
rs1475583165 1455 dbSNP
rs1005666371 1456 dbSNP
rs1391589632 1460 dbSNP
rs952751837 1476 dbSNP
rs1025710298 1477 dbSNP
rs72521176 1481 dbSNP
rs3842593 1483 dbSNP
rs869266775 1483 dbSNP
rs201984114 1484 dbSNP
rs994358987 1484 dbSNP
rs1324179155 1486 dbSNP
rs561495838 1492 dbSNP
rs905831163 1497 dbSNP
rs1301375136 1499 dbSNP
rs7674108 1501 dbSNP
rs1312154404 1502 dbSNP
rs1011765189 1505 dbSNP
rs1046643926 1506 dbSNP
rs761451727 1507 dbSNP
rs1212131934 1521 dbSNP
rs894181046 1522 dbSNP
rs375502854 1526 dbSNP
rs1053208200 1527 dbSNP
rs935776895 1534 dbSNP
rs904302187 1535 dbSNP
rs944174512 1540 dbSNP
rs1340571797 1542 dbSNP
rs1277962844 1544 dbSNP
rs201066408 1548 dbSNP
rs1397796989 1550 dbSNP
rs70962582 1550 dbSNP
rs33967166 1551 dbSNP
rs371257783 1552 dbSNP
rs3842594 1552 dbSNP
rs142978548 1554 dbSNP
rs778883199 1555 dbSNP
rs1312983567 1558 dbSNP
rs1473677337 1568 dbSNP
rs1165415021 1569 dbSNP
rs370983736 1570 dbSNP
rs575429166 1571 dbSNP
rs558561865 1572 dbSNP
rs1049918110 1578 dbSNP
rs757214412 1591 dbSNP
rs922391450 1592 dbSNP
rs1046236 1594 dbSNP
rs1317964798 1595 dbSNP
rs1410455168 1596 dbSNP
rs942598262 1597 dbSNP
rs1247389001 1598 dbSNP
rs919570157 1603 dbSNP
rs1294314507 1605 dbSNP
rs974059961 1617 dbSNP
rs573050446 1620 dbSNP
rs552980460 1621 dbSNP
rs376348615 1630 dbSNP
rs1485936261 1635 dbSNP
rs1204152944 1636 dbSNP
rs1259821174 1637 dbSNP
rs991996403 1643 dbSNP
rs1188315969 1659 dbSNP
rs1182525452 1662 dbSNP
rs536594266 1672 dbSNP
rs1482933929 1677 dbSNP
rs1235792056 1706 dbSNP
rs1161359657 1707 dbSNP
rs1207322957 1709 dbSNP
rs146128020 1710 dbSNP
rs1158101803 1715 dbSNP
rs1257877609 1716 dbSNP
rs1383003728 1722 dbSNP
rs375288788 1722 dbSNP
rs1313865846 1726 dbSNP
rs77225809 1732 dbSNP
rs970959000 1747 dbSNP
rs1413449526 1753 dbSNP
rs10009018 1760 dbSNP
rs1227261553 1763 dbSNP
rs569031248 1769 dbSNP
rs1318078741 1780 dbSNP
rs549091867 1786 dbSNP
rs895384731 1787 dbSNP
rs1032535103 1795 dbSNP
rs77911265 1797 dbSNP
rs904164862 1810 dbSNP
rs1256527420 1811 dbSNP
rs141606105 1816 dbSNP
rs773972092 1821 dbSNP
rs1041471682 1824 dbSNP
rs1251107120 1835 dbSNP
rs1418455368 1843 dbSNP
rs1181105888 1854 dbSNP
rs1362201468 1861 dbSNP
rs1436802390 1864 dbSNP
rs1399388237 1865 dbSNP
rs945776947 1869 dbSNP
rs1462757892 1871 dbSNP
rs1420309812 1877 dbSNP
rs546957530 1878 dbSNP
rs1041256245 1883 dbSNP
rs1008367158 1892 dbSNP
rs891256991 1900 dbSNP
rs1411773678 1907 dbSNP
rs530459909 1909 dbSNP
rs1049521858 1912 dbSNP
rs1234546473 1924 dbSNP
rs932392164 1925 dbSNP
rs1206969832 1926 dbSNP
rs1238062130 1937 dbSNP
rs1251687942 1944 dbSNP
rs911154973 1948 dbSNP
rs1197153515 1966 dbSNP
rs1175468666 1985 dbSNP
rs777304560 1986 dbSNP
rs398083857 2002 dbSNP
rs398108459 2002 dbSNP
rs545762211 2002 dbSNP
rs78174051 2002 dbSNP
rs1038052163 2004 dbSNP
rs984002961 2016 dbSNP
rs1194371450 2027 dbSNP
rs1394650887 2029 dbSNP
rs149874753 2034 dbSNP
rs1172899077 2037 dbSNP
rs931305160 2038 dbSNP
rs1220464062 2039 dbSNP
rs918588558 2046 dbSNP
rs1319527753 2053 dbSNP
rs780668152 2061 dbSNP
rs1440955853 2068 dbSNP
rs971206639 2073 dbSNP
rs772489819 2075 dbSNP
rs1215967837 2076 dbSNP
rs191936356 2079 dbSNP
rs770204342 2086 dbSNP
rs1296010198 2096 dbSNP
rs1376064084 2099 dbSNP
rs1202315089 2103 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000284776.7 | 3UTR | UUGAGGCAAAAAAAAAAAAAAAAAGUGUCUCCAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000284776.7 | 3UTR | AAAAAAAAAAAAAAAAAGUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000284776.7 | 3UTR | AAAAAAAAAAAAAAAAGUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000284776.7 | 3UTR | UGAGGCAAAAAAAAAAAAAAAAAGUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000284776.7 | 3UTR | UUGAGGCAAAAAAAAAAAAAAAAAGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000284776.7 | 3UTR | AUUUGAGGCAAAAAAAAAAAAAAAAAGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000284776.7 | 3UTR | AAAAAAAAAAAAAAAAGUGUCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000284776.7 | 3UTR | UGAGGCAAAAAAAAAAAAAAAAAGUGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
75 hsa-miR-3152-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092535 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT461731 NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 2 2
MIRT468456 SET SET nuclear proto-oncogene 2 2
MIRT482192 AHR aryl hydrocarbon receptor 2 2
MIRT507923 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT512208 C18orf25 chromosome 18 open reading frame 25 2 6
MIRT526238 STARD4 StAR related lipid transfer domain containing 4 2 2
MIRT536131 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536280 LIMA1 LIM domain and actin binding 1 2 2
MIRT544251 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT548054 GOLGA7 golgin A7 2 2
MIRT563443 ISCA1 iron-sulfur cluster assembly 1 2 2
MIRT565643 SIX4 SIX homeobox 4 2 2
MIRT614870 PDE12 phosphodiesterase 12 2 2
MIRT614923 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT615793 FAM124A family with sequence similarity 124 member A 2 2
MIRT618557 VLDLR very low density lipoprotein receptor 2 2
MIRT622147 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT622390 RSBN1 round spermatid basic protein 1 2 2
MIRT624185 DDX19B DEAD-box helicase 19B 2 2
MIRT624448 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT625340 TAPBP TAP binding protein 2 2
MIRT625370 IRGQ immunity related GTPase Q 2 2
MIRT627276 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT627746 RAD54L2 RAD54 like 2 2 2
MIRT629578 RFC2 replication factor C subunit 2 2 4
MIRT630537 LGALS8 galectin 8 2 4
MIRT630559 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT630568 SOWAHA sosondowah ankyrin repeat domain family member A 2 4
MIRT630763 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT635424 LRP10 LDL receptor related protein 10 2 2
MIRT636011 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT636337 PHAX phosphorylated adaptor for RNA export 2 2
MIRT638413 POU3F2 POU class 3 homeobox 2 2 2
MIRT639358 INIP INTS3 and NABP interacting protein 2 2
MIRT642124 DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A 2 4
MIRT642828 KIAA0319 KIAA0319 2 2
MIRT644017 NUCB1 nucleobindin 1 2 2
MIRT644038 WWC2 WW and C2 domain containing 2 2 2
MIRT644153 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644649 SNX9 sorting nexin 9 2 2
MIRT645798 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT647633 FAIM2 Fas apoptotic inhibitory molecule 2 2 2
MIRT648528 KIAA1143 KIAA1143 2 2
MIRT648851 PDLIM3 PDZ and LIM domain 3 2 2
MIRT648880 TUBGCP5 tubulin gamma complex associated protein 5 2 2
MIRT650777 TNFRSF10A TNF receptor superfamily member 10a 2 2
MIRT654200 RNF19B ring finger protein 19B 2 2
MIRT654508 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT655249 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT656089 MTA3 metastasis associated 1 family member 3 2 2
MIRT656599 LRRC55 leucine rich repeat containing 55 2 2
MIRT659194 CYBB cytochrome b-245 beta chain 2 2
MIRT660000 C1orf115 chromosome 1 open reading frame 115 2 4
MIRT661715 KLF8 Kruppel like factor 8 2 2
MIRT661813 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT668360 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT679734 CABP4 calcium binding protein 4 2 2
MIRT708616 NUDT18 nudix hydrolase 18 2 2
MIRT709034 TROVE2 TROVE domain family member 2 2 2
MIRT709573 DMGDH dimethylglycine dehydrogenase 2 2
MIRT709665 AJAP1 adherens junctions associated protein 1 2 2
MIRT709874 TRAF1 TNF receptor associated factor 1 2 2
MIRT710821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT710883 PARL presenilin associated rhomboid like 2 2
MIRT711547 LCAT lecithin-cholesterol acyltransferase 2 2
MIRT712017 STX1B syntaxin 1B 2 2
MIRT713058 BLVRA biliverdin reductase A 2 2
MIRT713129 THRB thyroid hormone receptor beta 2 2
MIRT713878 MOB3A MOB kinase activator 3A 2 2
MIRT714154 NXPH3 neurexophilin 3 2 2
MIRT719755 FLYWCH1 FLYWCH-type zinc finger 1 2 2
MIRT720213 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT722728 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT725652 ABI2 abl interactor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)

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