miRTarBase - #MIRT623088


—
pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol NME6   
Synonyms IPIA-ALPHA, NDK 6, NM23-H6
Description NME/NM23 nucleoside diphosphate kinase 6
Transcript NM_005793   
Expression
Putative miRNA Targets on NME6
3'UTR of NME6
(miRNA target sites are highlighted)		 
>NME6|NM_005793|3'UTR
   1 TGCAGGTCTATGAAGACCAGTGGTAGTGCCCAGACTTCTCCTAGACATCTAGTCTAAAACATTCTCCTAGGACCAGGGAA
  81 GCCTGGCTTACAGTGCCATTTCTGCTGGGCACCACCACCTGCCTGAGGGCCTAGCTCACCACAGCACATCCTCCAGGATC
 161 TAGCCTTCTATCTACCTCTTCTCTGGAATGTTTATGGTGGTTCAGAAGAATGATGACTCCTCTTTGCTGAGAACTGTTCA
 241 TCCTTCTTCAAGAAGAAGCTTGCCAGGCCGGGCACGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCAG
 321 GCGGATCACAAGGTCAGGAATTCGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAACAATTAG
 401 CCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCAGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAG
 481 GGTGCAGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGCGACATTCTGTCTCAAAAAAAAAAAAAAAGAAGCTTGT
 561 CTAATTGACTTGCCTAAAAAATGCAGTGACTCCAAACAACATTTGACCTGTCTTCCTCAATAAAAGTCAGTGTTCTCCTG
 641 AATCCTTTATGCTGCCACATTTAGGGGAAACTTTTCAGGCTTCATCATTCTGACTTCTCAGCAGCATTCAGTTATTGCTT
 721 CATTCTCCAGAAACACTCTCTTCTCTTGGATTTTCTGATCCCACACCCTTGGTTTTCTCCTTCTGTGTGTTTTTCTTCAT
 801 CTCCTTTATCAGCTTATGCAAACATTTATTTTCATAAATTCTCTATTCAAGACATACTGAAAAATGCAAAGATGGTTAAG
 881 ACATGATTGGGTCCTCAAGTTGCTAATTATGAATTTGGGTGGTCAGCCAGCTATAACGTGGCAGAGATGGAGAAGTGCCC
 961 TAACAGAGGTATAAAGTCCTGTGGGAGAACAGAGGAAAGAAGGTTTCCTTTGGCTGGGTGAGGAGGTGAAGGAGATAGGG
1041 TGGAAAGTCTTTTATAAAAGATATAGCTGGCTTTGGAACTAAGCCTGAAGGTCAAATAGGGTATCCATAGCAGGGGTCTG
1121 GGGCACTAGACAGTCTGTTCATTTTCAGGAATATATGGGTCAGTTTTGTATGTGTGACCTAAGAAACCTGTGACACTTCT
1201 TACAGGTCTTGACTTTTCTTTCTCAGTACATGTGTATTTCTCTTTTTGGTGGCCTTGAAACCTTTGAGTTGAAAATTGCC
1281 TTCACCATCTGCCACTTTCACTAATGGTAGACCAGGAAATTTGGACCCACTGAACATAGAGAACAACTAGAAAAGCTGTG
1361 CAAAATATAAACAGCATCTATCTGAAAGCATCAGCTGGCAATATAGAACCAAAATTCAGGACACGAAGGAAACTCAAGAG
1441 AAGTGAGCCTGGGACTTAGAGCTACTTTTCCCATAAGGGCACCTGCTGATTCTGGAAGAGGCAGCTAAGAAGCTGAGTAG
1521 AACTTTCAACAACTTCTTGTGTTAGGGAGCCAGCTTCATGAATGCTGGCAGAAAACACAGGATTACTTGGGCAGAGACTA
1601 CTGCTCAGGGCACAGCAGGCAGTGTGTTAGCCTTGGTCTCCCTTGCCCTCCAAGTCCCACAGGGCAATACTGGCAGGCCC
1681 AGGAAAGTGTTACACACTGCAGGTTTGCATGACGGCTAAGGAACCACAATCTTAGGGAGATACTATCTCTGTCTTCTAAG
1761 GCCATTTGCTGTACAAAAATCCTTGAAATACCTGGGCACAGTGGCACACCTATAATCCTAGCACTTTGGGAGGCTGAGGC
1841 AGGCGGATCACCTGAGGTTGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAATCCCGTCTCTACTAAAAATACAAAAA
1921 TTAGCCAAGCGTGGTGGCGCGAGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGC
2001 GGAGGTTGTGGTGAGCCAAGATCACGCCGTTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCTCAAGAAAAAAAA
2081 AATCCTTGAAATAGTCTGGAACAAAATCTGTCAACATCTCAGCCCACAAAGTATCAACAAAATTGATATTTTGTTGCATT
2161 TAAAAAATTTAAATGGTGGTCAAAGCGTACAAAATCTGACAATTAAGACACCCACAAGAGACACAGAATTATCTCCCAAT
2241 AAAATTGTCTCATAAAAACCTGGCTCCCACAAATATGGAAAGGGAGAAAACTAGAATAAACCCTGTGGTGTCGAATTGGA
2321 AAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaccccaccccuGUCUCCGAa 5'
                      |||||||| 
Target 5' atcccagctactCAGAGGCTg 3'
 426 - 446 145.00 -12.30
2 
miRNA  3' gaccccACCC-CUGUCUCCGAa 5'
                |||| |:|||||| | 
Target 5' tgaaccTGGGAGGCAGAGGGTg 3'
 463 - 484 131.00 -19.00
3 
miRNA  3' gaccccaccCCUGUCUCCGaa 5'
                   ||| ||||||  
Target 5' gctgattctGGA-AGAGGCag 3'
 1485 - 1504 127.00 -12.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31583748 2 COSMIC
COSN31491779 48 COSMIC
COSN29468595 172 COSMIC
COSN16129142 229 COSMIC
COSN28818185 270 COSMIC
COSN26575114 274 COSMIC
COSN6769299 313 COSMIC
COSN28818061 319 COSMIC
COSN1951454 515 COSMIC
COSN32061261 537 COSMIC
COSN24471930 552 COSMIC
COSN9552762 808 COSMIC
COSN6769297 933 COSMIC
COSN6769296 1153 COSMIC
COSN1951453 1700 COSMIC
COSN8347906 1868 COSMIC
COSN7762703 1979 COSMIC
COSN29529033 2072 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs11545439 1 dbSNP
rs752476972 2 dbSNP
rs74477624 3 dbSNP
rs759898308 4 dbSNP
rs986221120 6 dbSNP
rs1329145937 8 dbSNP
rs967049051 9 dbSNP
rs188911902 10 dbSNP
rs762960209 22 dbSNP
rs1360214418 23 dbSNP
rs1178695466 25 dbSNP
rs990476132 30 dbSNP
rs1441265453 35 dbSNP
rs1427049291 37 dbSNP
rs1389931112 40 dbSNP
rs1189497082 41 dbSNP
rs761247737 43 dbSNP
rs773289331 43 dbSNP
rs990505573 45 dbSNP
rs958689097 47 dbSNP
rs761488262 52 dbSNP
rs186108639 64 dbSNP
rs1002739909 69 dbSNP
rs1221435578 76 dbSNP
rs768418713 77 dbSNP
rs181840018 79 dbSNP
rs1134866 87 dbSNP
rs1274846884 92 dbSNP
rs1242433726 99 dbSNP
rs1474484005 105 dbSNP
rs1188304737 110 dbSNP
rs1420285577 111 dbSNP
rs898512392 119 dbSNP
rs1321038274 120 dbSNP
rs1162696859 130 dbSNP
rs971191372 131 dbSNP
rs1024089714 137 dbSNP
rs1343025104 143 dbSNP
rs1012666453 158 dbSNP
rs535359418 159 dbSNP
rs1038409495 160 dbSNP
rs894167249 170 dbSNP
rs1228315143 171 dbSNP
rs1291919517 174 dbSNP
rs1337406848 183 dbSNP
rs537375760 193 dbSNP
rs994873212 194 dbSNP
rs1445543565 210 dbSNP
rs890070952 214 dbSNP
rs1051680832 222 dbSNP
rs1218170535 228 dbSNP
rs898103346 229 dbSNP
rs1242841643 232 dbSNP
rs1036546181 233 dbSNP
rs553599438 242 dbSNP
rs1185717753 251 dbSNP
rs944906355 253 dbSNP
rs1441223613 259 dbSNP
rs912044701 259 dbSNP
rs1158212980 262 dbSNP
rs1405485074 269 dbSNP
rs3197223 270 dbSNP
rs571316188 275 dbSNP
rs1050349897 280 dbSNP
rs945655033 282 dbSNP
rs777845191 285 dbSNP
rs1357857429 288 dbSNP
rs932074757 289 dbSNP
rs1279376866 290 dbSNP
rs915276925 293 dbSNP
rs1420933775 295 dbSNP
rs989866653 298 dbSNP
rs989497427 300 dbSNP
rs1208755781 302 dbSNP
rs1259676594 308 dbSNP
rs1378571189 311 dbSNP
rs1181355188 312 dbSNP
rs1178214798 313 dbSNP
rs549864838 314 dbSNP
rs1158787486 315 dbSNP
rs1423984496 318 dbSNP
rs1134867 319 dbSNP
rs927256417 322 dbSNP
rs374466881 323 dbSNP
rs971218504 326 dbSNP
rs1025652573 329 dbSNP
rs972796496 330 dbSNP
rs977323190 342 dbSNP
rs759403588 343 dbSNP
rs1350817959 349 dbSNP
rs1307907097 352 dbSNP
rs1234497427 353 dbSNP
rs1372705435 355 dbSNP
rs866991904 362 dbSNP
rs962801005 372 dbSNP
rs1024134537 374 dbSNP
rs1232327726 375 dbSNP
rs1282643367 385 dbSNP
rs1348665182 391 dbSNP
rs1013129967 397 dbSNP
rs1017333471 397 dbSNP
rs1270711612 401 dbSNP
rs1385418945 406 dbSNP
rs1439380367 407 dbSNP
rs1182203627 409 dbSNP
rs1006914366 415 dbSNP
rs748355494 420 dbSNP
rs1195109716 422 dbSNP
rs1395223309 424 dbSNP
rs1027794920 426 dbSNP
rs1455835601 427 dbSNP
rs1358627553 428 dbSNP
rs1394906957 431 dbSNP
rs548988766 438 dbSNP
rs897484340 441 dbSNP
rs1036598728 446 dbSNP
rs1029926634 450 dbSNP
rs1009102968 459 dbSNP
rs998320720 462 dbSNP
rs902686171 465 dbSNP
rs1197086476 470 dbSNP
rs1226725768 472 dbSNP
rs1042619132 476 dbSNP
rs890656335 480 dbSNP
rs1196277286 484 dbSNP
rs1262211812 486 dbSNP
rs1466962327 487 dbSNP
rs528038501 493 dbSNP
rs753557048 495 dbSNP
rs1487276820 500 dbSNP
rs1190460106 502 dbSNP
rs945771259 506 dbSNP
rs903846259 510 dbSNP
rs892916901 511 dbSNP
rs1476711120 517 dbSNP
rs1054511581 523 dbSNP
rs1168981113 523 dbSNP
rs1328206322 527 dbSNP
rs1381844514 532 dbSNP
rs1395435993 532 dbSNP
rs1285297731 534 dbSNP
rs1050622149 535 dbSNP
rs1215195346 536 dbSNP
rs1253857393 537 dbSNP
rs1292539067 538 dbSNP
rs1332419608 541 dbSNP
rs1232102309 544 dbSNP
rs1273556590 545 dbSNP
rs1485362939 549 dbSNP
rs1330845019 551 dbSNP
rs1263293321 552 dbSNP
rs369905058 552 dbSNP
rs536239952 552 dbSNP
rs71074229 552 dbSNP
rs751955896 552 dbSNP
rs1474441795 554 dbSNP
rs1296744399 555 dbSNP
rs1418993971 555 dbSNP
rs932101371 555 dbSNP
rs1402335321 556 dbSNP
rs1387253057 562 dbSNP
rs1382785797 567 dbSNP
rs1312232807 572 dbSNP
rs937043444 576 dbSNP
rs1339086549 582 dbSNP
rs1293749633 592 dbSNP
rs927175607 595 dbSNP
rs373204181 600 dbSNP
rs1415452450 601 dbSNP
rs1209462501 603 dbSNP
rs1254751904 605 dbSNP
rs538698528 607 dbSNP
rs1485002261 612 dbSNP
rs1054250311 613 dbSNP
rs1257374942 630 dbSNP
rs1404471484 635 dbSNP
rs949849533 638 dbSNP
rs1157203386 645 dbSNP
rs1171001489 653 dbSNP
rs560768296 658 dbSNP
rs918409190 659 dbSNP
rs1465739457 662 dbSNP
rs1373378979 663 dbSNP
rs1373706016 666 dbSNP
rs972567238 667 dbSNP
rs962748798 674 dbSNP
rs1313349999 676 dbSNP
rs1172257031 689 dbSNP
rs190462557 694 dbSNP
rs1308720401 702 dbSNP
rs1336030647 718 dbSNP
rs1233075295 722 dbSNP
rs1277662274 726 dbSNP
rs923919427 733 dbSNP
rs1262347335 735 dbSNP
rs533584865 738 dbSNP
rs985834552 740 dbSNP
rs1480530056 742 dbSNP
rs550750441 742 dbSNP
rs755386242 743 dbSNP
rs761938525 750 dbSNP
rs1440619861 764 dbSNP
rs1030287440 767 dbSNP
rs1199461224 768 dbSNP
rs1464586562 770 dbSNP
rs1176740847 772 dbSNP
rs1339672080 777 dbSNP
rs1299711413 785 dbSNP
rs1460379709 785 dbSNP
rs1396945158 798 dbSNP
rs1252761432 804 dbSNP
rs1439785624 810 dbSNP
rs1220816222 812 dbSNP
rs1300736945 817 dbSNP
rs998435291 818 dbSNP
rs1027436260 824 dbSNP
rs562909530 829 dbSNP
rs146808113 837 dbSNP
rs1342278187 838 dbSNP
rs973111205 842 dbSNP
rs1203029144 845 dbSNP
rs766808325 856 dbSNP
rs1458448415 867 dbSNP
rs961728018 870 dbSNP
rs1251327004 872 dbSNP
rs1455655838 874 dbSNP
rs552075970 875 dbSNP
rs1418850695 883 dbSNP
rs143699254 887 dbSNP
rs1426735644 902 dbSNP
rs1172436306 905 dbSNP
rs1395585995 911 dbSNP
rs1011104076 918 dbSNP
rs1008481149 926 dbSNP
rs1397482163 933 dbSNP
rs1323520431 935 dbSNP
rs890708818 937 dbSNP
rs139261181 938 dbSNP
rs1436722585 939 dbSNP
rs1287824419 941 dbSNP
rs1422678703 950 dbSNP
rs1359237767 954 dbSNP
rs1213339230 955 dbSNP
rs1054226613 969 dbSNP
rs1001575934 971 dbSNP
rs1476149302 979 dbSNP
rs1366141604 989 dbSNP
rs905532998 992 dbSNP
rs1319072710 1003 dbSNP
rs754891429 1003 dbSNP
rs529636190 1022 dbSNP
rs1437949281 1024 dbSNP
rs1045414754 1031 dbSNP
rs949955508 1039 dbSNP
rs996370870 1041 dbSNP
rs893951890 1049 dbSNP
rs1053898555 1054 dbSNP
rs1196394786 1057 dbSNP
rs1188212543 1061 dbSNP
rs184417395 1064 dbSNP
rs935399864 1071 dbSNP
rs918525161 1082 dbSNP
rs1036800984 1083 dbSNP
rs1405652525 1090 dbSNP
rs941215725 1101 dbSNP
rs1257831358 1104 dbSNP
rs1234379069 1125 dbSNP
rs909922785 1128 dbSNP
rs1359064486 1129 dbSNP
rs1046435984 1131 dbSNP
rs1283016020 1135 dbSNP
rs868103554 1136 dbSNP
rs985564248 1147 dbSNP
rs949342926 1149 dbSNP
rs954308450 1151 dbSNP
rs1444877044 1155 dbSNP
rs1229118942 1156 dbSNP
rs145585762 1168 dbSNP
rs1315235653 1171 dbSNP
rs1217982289 1199 dbSNP
rs1399189929 1202 dbSNP
rs991803709 1203 dbSNP
rs937215106 1205 dbSNP
rs1185706901 1208 dbSNP
rs920422666 1213 dbSNP
rs1326348818 1218 dbSNP
rs758872265 1221 dbSNP
rs1406933573 1222 dbSNP
rs1405281469 1223 dbSNP
rs1402059830 1225 dbSNP
rs1388481713 1230 dbSNP
rs922620980 1231 dbSNP
rs1158761263 1238 dbSNP
rs976777695 1253 dbSNP
rs1374312895 1257 dbSNP
rs1470157392 1266 dbSNP
rs192442634 1283 dbSNP
rs1342643576 1287 dbSNP
rs973163579 1293 dbSNP
rs1279213582 1294 dbSNP
rs1371514363 1297 dbSNP
rs1021235943 1298 dbSNP
rs961774369 1299 dbSNP
rs1347167812 1306 dbSNP
rs1208645027 1326 dbSNP
rs1282330328 1327 dbSNP
rs1014585915 1334 dbSNP
rs749930814 1336 dbSNP
rs1230928787 1341 dbSNP
rs189825175 1354 dbSNP
rs954496057 1355 dbSNP
rs1393974265 1356 dbSNP
rs1451963635 1364 dbSNP
rs1214704618 1365 dbSNP
rs1172354991 1370 dbSNP
rs1404923508 1372 dbSNP
rs1029274512 1374 dbSNP
rs1328651541 1378 dbSNP
rs1011051811 1388 dbSNP
rs577789907 1395 dbSNP
rs1033138098 1398 dbSNP
rs894013158 1419 dbSNP
rs1232117624 1424 dbSNP
rs1209789948 1425 dbSNP
rs1345678127 1434 dbSNP
rs1351439795 1438 dbSNP
rs1270689166 1444 dbSNP
rs1001291746 1445 dbSNP
rs556068239 1453 dbSNP
rs905635424 1457 dbSNP
rs1458882752 1459 dbSNP
rs1198891428 1467 dbSNP
rs764756735 1471 dbSNP
rs761423177 1473 dbSNP
rs1377668398 1483 dbSNP
rs999655502 1500 dbSNP
rs776235357 1504 dbSNP
rs897048094 1510 dbSNP
rs537985093 1513 dbSNP
rs1467472532 1527 dbSNP
rs1332325776 1529 dbSNP
rs941151490 1534 dbSNP
rs909713057 1535 dbSNP
rs1329157545 1538 dbSNP
rs1055756035 1539 dbSNP
rs1331739897 1543 dbSNP
rs1226616833 1545 dbSNP
rs1050058204 1547 dbSNP
rs1401224042 1558 dbSNP
rs1361835847 1580 dbSNP
rs567365199 1582 dbSNP
rs79642706 1589 dbSNP
rs369493488 1590 dbSNP
rs1211261028 1601 dbSNP
rs976726816 1603 dbSNP
rs1395282156 1605 dbSNP
rs763944405 1606 dbSNP
rs546727407 1640 dbSNP
rs1479076007 1641 dbSNP
rs966715261 1645 dbSNP
rs914123672 1649 dbSNP
rs1171879403 1650 dbSNP
rs1417582831 1654 dbSNP
rs1460121933 1664 dbSNP
rs1165157714 1668 dbSNP
rs1391554633 1672 dbSNP
rs1479179932 1672 dbSNP
rs112107331 1681 dbSNP
rs1245373625 1692 dbSNP
rs907641509 1693 dbSNP
rs1342349302 1696 dbSNP
rs1488910837 1697 dbSNP
rs376916106 1713 dbSNP
rs989752374 1714 dbSNP
rs561087223 1716 dbSNP
rs775211641 1728 dbSNP
rs1033847297 1731 dbSNP
rs981368634 1734 dbSNP
rs1281247929 1739 dbSNP
rs774568400 1741 dbSNP
rs1221187416 1745 dbSNP
rs528459432 1747 dbSNP
rs1342534583 1758 dbSNP
rs1024020155 1759 dbSNP
rs1195010060 1760 dbSNP
rs1013839509 1763 dbSNP
rs1422360668 1779 dbSNP
rs896827816 1781 dbSNP
rs1342291530 1785 dbSNP
rs1453301865 1786 dbSNP
rs1015251460 1789 dbSNP
rs533434376 1795 dbSNP
rs1420293896 1808 dbSNP
rs1032572159 1813 dbSNP
rs563134701 1819 dbSNP
rs1313131920 1820 dbSNP
rs1049563091 1832 dbSNP
rs966856338 1834 dbSNP
rs550887781 1835 dbSNP
rs1375540276 1838 dbSNP
rs932497038 1841 dbSNP
rs529438636 1844 dbSNP
rs1202605974 1845 dbSNP
rs1423425091 1858 dbSNP
rs1418787870 1864 dbSNP
rs1041159876 1870 dbSNP
rs184126877 1879 dbSNP
rs1178043878 1882 dbSNP
rs1440326633 1884 dbSNP
rs771911530 1887 dbSNP
rs1373610111 1891 dbSNP
rs1467493563 1899 dbSNP
rs1055545306 1906 dbSNP
rs945382852 1907 dbSNP
rs1172345049 1908 dbSNP
rs745780621 1912 dbSNP
rs1310907149 1914 dbSNP
rs989923805 1917 dbSNP
rs1377031570 1920 dbSNP
rs1232866767 1921 dbSNP
rs1300602000 1921 dbSNP
rs1311001091 1923 dbSNP
rs1236070274 1925 dbSNP
rs1257013920 1927 dbSNP
rs936917795 1928 dbSNP
rs1480478469 1929 dbSNP
rs191706143 1930 dbSNP
rs549382244 1931 dbSNP
rs1458364306 1938 dbSNP
rs1265933455 1939 dbSNP
rs980932621 1940 dbSNP
rs540290085 1941 dbSNP
rs572918504 1942 dbSNP
rs1212440012 1946 dbSNP
rs1310655307 1949 dbSNP
rs1372290446 1951 dbSNP
rs564112625 1953 dbSNP
rs992534108 1957 dbSNP
rs1400641391 1961 dbSNP
rs531246395 1962 dbSNP
rs769882369 1964 dbSNP
rs1369083708 1969 dbSNP
rs899103292 1981 dbSNP
rs563826692 1983 dbSNP
rs770253582 1984 dbSNP
rs888347197 1991 dbSNP
rs545315982 1994 dbSNP
rs1318949845 2000 dbSNP
rs996659466 2001 dbSNP
rs901011069 2002 dbSNP
rs1335496839 2004 dbSNP
rs907695212 2006 dbSNP
rs1355464818 2010 dbSNP
rs1051500678 2016 dbSNP
rs1445246925 2025 dbSNP
rs1476789127 2026 dbSNP
rs1172611905 2028 dbSNP
rs1424072070 2029 dbSNP
rs1040939960 2031 dbSNP
rs921662965 2033 dbSNP
rs1466448882 2036 dbSNP
rs1275634120 2040 dbSNP
rs1426275798 2045 dbSNP
rs1294656018 2047 dbSNP
rs1398688656 2053 dbSNP
rs769627463 2053 dbSNP
rs945437883 2056 dbSNP
rs892586360 2057 dbSNP
rs1477789939 2066 dbSNP
rs1415230868 2070 dbSNP
rs1183670169 2072 dbSNP
rs1232902079 2083 dbSNP
rs925556302 2083 dbSNP
rs978322989 2089 dbSNP
rs1237101992 2094 dbSNP
rs1199536561 2096 dbSNP
rs1458892490 2108 dbSNP
rs1487307822 2109 dbSNP
rs966908845 2111 dbSNP
rs1263648400 2115 dbSNP
rs1025142081 2116 dbSNP
rs1179788033 2120 dbSNP
rs1415451409 2121 dbSNP
rs1013722654 2124 dbSNP
rs577849874 2125 dbSNP
rs959720750 2126 dbSNP
rs1255920123 2133 dbSNP
rs746293449 2135 dbSNP
rs755194008 2138 dbSNP
rs1361605338 2139 dbSNP
rs1322238166 2144 dbSNP
rs1447693317 2149 dbSNP
rs113954705 2153 dbSNP
rs747380553 2157 dbSNP
rs1282763623 2167 dbSNP
rs777740380 2171 dbSNP
rs1226085756 2175 dbSNP
rs1306462708 2181 dbSNP
rs556368209 2186 dbSNP
rs537646747 2187 dbSNP
rs1279730992 2190 dbSNP
rs1016158098 2191 dbSNP
rs1207818564 2196 dbSNP
rs981431654 2198 dbSNP
rs1472954728 2202 dbSNP
rs1329713165 2205 dbSNP
rs1176209225 2207 dbSNP
rs949676272 2209 dbSNP
rs1377953129 2211 dbSNP
rs758852538 2213 dbSNP
rs972232918 2214 dbSNP
rs1052040947 2215 dbSNP
rs1381524760 2217 dbSNP
rs933145423 2218 dbSNP
rs750921793 2219 dbSNP
rs1038769926 2226 dbSNP
rs1449049305 2228 dbSNP
rs1413201585 2235 dbSNP
rs1374811623 2238 dbSNP
rs867837594 2242 dbSNP
rs187203637 2257 dbSNP
rs1179415737 2264 dbSNP
rs983775692 2266 dbSNP
rs1310053865 2269 dbSNP
rs1344304158 2276 dbSNP
rs150504859 2279 dbSNP
rs371623787 2291 dbSNP
rs1442716157 2293 dbSNP
rs1028204241 2294 dbSNP
rs182957460 2300 dbSNP
rs965324441 2302 dbSNP
rs945620792 2303 dbSNP
rs1019448478 2304 dbSNP
rs918136775 2309 dbSNP
rs1488706906 2312 dbSNP
rs992752933 2313 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaccccaccccuGUCUCCGAa 5'
                      |||||||| 
Target 5' --------uacuCAGAGGCUg 3'
 		1 - 13
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000450160.1 | 3UTR | CUCAGAGGCUGAGGCAGGAGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000450160.1 | 3UTR | UACUCAGAGGCUGAGGCAGGAGAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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