miRTarBase - #MIRT623883


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pre-miRNA Information
pre-miRNA hsa-mir-1268b   
Genomic Coordinates chr17: 80098828 - 80098877
Description Homo sapiens miR-1268b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1268b
Sequence 4| CGGGCGUGGUGGUGGGGGUG |23
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs565586973 1 dbSNP
rs1007008765 2 dbSNP
rs1405843504 4 dbSNP
rs535896040 5 dbSNP
rs532706583 6 dbSNP
rs1290047771 7 dbSNP
rs1228621577 10 dbSNP
rs1377910066 10 dbSNP
rs1282084939 12 dbSNP
rs1449528405 13 dbSNP
rs148335705 13 dbSNP
rs893367645 16 dbSNP
rs1222208792 18 dbSNP
rs1456165025 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FRMPD4   
Synonyms MRX104, PDZD10, PDZK10
Description FERM and PDZ domain containing 4
Transcript NM_014728   
Expression
Putative miRNA Targets on FRMPD4
3'UTR of FRMPD4
(miRNA target sites are highlighted)		 
>FRMPD4|NM_014728|3'UTR
   1 CTTTGACAGAGCCTGGGAAGGAGAGACGAGGAGGCATGCCTTCAGCTTGGTCTCAACATCCTGAAGCTGATCCCATCCTG
  81 CTACCATCAAACATTCACTCGGAATCAAAGGTGCCAATTCCAAATCAAGACCCTAATGATTTCTCCCAAGCAAATCAGGC
 161 ATACGGAGAGGCTGTGAGCTGGCGGCCACCGGATCTGAGAGGGGGGAGCCTCAGGACACCTCCCAGCCAGAAGGCTCTGA
 241 GACATAGCAGCAGTATCCTCTCCGGATCTGTCGATTTGGAGACCTTCCGAGAGAGAACCAAGGGTGCAGTCAGCTTAAAG
 321 TGTCCAGGCATCACAGAAGCACAGGAGGCCAGTTCTGAAAGGCGAGCAGAACTCCCCCTGGGGAGGAAGCTCACCAAAAG
 401 TTTTTCCCAAAGCTCAATGCACTTGAGCTCTGAGGGGAGGTTTCACAAAAGGTCCCCAGTGGCTCATAAAGACTCAAAGC
 481 TGTATAGGACATTACCCTTGCGGAAGCTGGAGGGCAGCAATTGGAGATGCCGGGGACCCTTCAGCTATTGCTTCCTGAAC
 561 CGAGGGCAGGATGAAGATGGTGAGGAAGAAGAGGAGAGGGGAGAGGCCACCGTCCAGGTCTCTTGCCTCTATAGACCACA
 641 GATGACTCAAGCCATGCCAGAACCAAGCAGCCCATGCCTGGCTGTGGCGATTCAGAAGCAACGAGGGGAGCTATCCAGAG
 721 GGTCAGTGCTGAAGGTCTGGGCAGAAGACCTGCGAGACCCAGATGACTTGGACTTCAGCAACCTGGCTTTTGATGCCCGG
 801 ATTGCAAGAATAAATGCCCTAAAGGAGAGCACATATGCAATGCCTGATGGGTTCCTTGCAGCCCAAAATGATGCCAATGA
 881 GCTGCTCTGTCTCGTCAGGGCAACCAAGGAGAAGAGGGAGGAGTCACGCCCTGAAGCGTACGACCTTACACTTTCTCAGT
 961 ACAAGCAACTGTTATCCATTGAGTCCAGACAGTTGGGAAGTGCCTGTAGGAAAATGGCGATGGCTGAGAAAAGCCCGGAG
1041 GAGATGCTCCTAGCTATGACTTCCAGCTTTCAAGTGCTCTGTTGCCTAACAGAAGCTTGCATGCGATTAGTTAAAGTCGT
1121 GAACTCAGAAACACAGCGGCAGGAAATTGTAGGGAAGATCGATGAAGTGGTCATAAATTACATTTGTCTACTGAAAGCTG
1201 CCGAAGCAGCCACTGGAAAGAACCCTGGGGACCCTAATGTTGGACTCTCGGCGCGACACTCAACCACCATGGCCGCTCTC
1281 GTAAGCACACTGACACGTTCTCTCAAGAGGCTTTTAAACAAATAAATATGGAAGTCACGTCATAATCTACCTTTGCAAAG
1361 CCATACATGAACTTTTATTTACTTTGTGTGTATGATGAACAGATGTCTCCTTTCTTCTCTCTGTATATTTTGTTATTTTA
1441 TATAAAATAGGAGATAAAAGTCACATTGATGAAATGTTGAAATGTACTAATCAGATGTATTCTGTTTATATTATACATAT
1521 ATATACACGTAAAAGAAATATCCAAGAAAGTGATGACATTTGGCTATTTTTCATATAGTTAAAACTCCAGGTATATGATG
1601 TGAAATTTTAAATTCTACCATGTTAGAGCAAAACAATGAATCCTATCCCCTTTCTTTCCAAGTAGCTACTTGGAAACCAT
1681 ATCATTCATATTTAGAAGTAAAACACAAAACAAAAAAGAGAGAGAAAAGAAAAGAAATCACAATGTATATAAAACAGTAC
1761 TTATGTTTTAAAATTATGATTTTTAAGCATTGGAAATAGCAAAAAGACATTTAAAATTCAAGAAGCTATTATGAATTACT
1841 AGAGAATATATCTGTAATAAATTAATTTTTTGCTCATAGTATTTGGTTACTGGATGCTTTCTTCCAAGAATCCCACATAT
1921 TTAATTTGGGTTTTTGCTACTGGGGCTACAAATTGGTGGGGATGGATTCTACTGTGTCAGCACAAATGCTCTTCACAGTG
2001 GTTCTAGCATTTAAAAAACTTCCCGGGGAGAAGAACAGAGGGGATGATGGGCAGTTTCCTAGGTAACACCTAGAGTTATA
2081 GAATATCTCATTACATAAAATGTATGGAATTAATAATACCAAAATTAATTATTTGATGGAAAGATCTGCTTTGACTAAAT
2161 GTCAAAAATCTGCAAACCAAAGACATTATCTTCCCCTCATCCCAACTCAACTACGAAACTTAAAATTCCCTTTAGAGTGA
2241 TAGGACATTTAGTAAAGTATTTGCAAACTTAAAAAAAGGAACATTTAATGATCATCAAAATTAAGTACAGATTCAGTAAT
2321 GTAGACCAGACCACACACCAGCACCTGTGAGTCTCATCTCAGATCACAGCTCTCAGCATAGGGCTTCATGCATCACCGCC
2401 TCTACAGAGGCTAAGGCTGCCAGTCAAATTTGGAATTATAGCGTAGTACTGGGACAAAATCTCAAATCTTGGATGTTCCA
2481 GAAAATCAGGGAGAGATGGCTACTGTAATCATGGGAGCCATGAGTAAATAGTTAAGTATTTATTAAATAAATACTTAATC
2561 TGGATTGGCTGATAAAAATATGAAATCTGAAAAAAAAAAGAAAGAAATGGAAGTGGTATATTTGACCAGTTCAAGTGAAA
2641 CCAATGGAATGCAAAGAACTTTCCAGGACTGTCACATCTCTAAAAGTACCCTGCAGTCATAAAATAAAATCGATATGTAT
2721 ATATGTATTTCCTGGGTCATTCAGTGCTCAAGTTACATGCACTCCTACTTAGACAGGTGGCTCCTTAAGAACATGATGGG
2801 AGTACACCAGGTGCAAATATTTCTACTTTTGTAGCCTGCTGAGAAGGAGTCATAACACAGTCCACAATTGCAATCTCTCT
2881 CTAGTCAGCCATTCCACAGGGACTCAACAACAAAAGCCGCACGTGGTTATGGATGGCAGCAAAGGAAAGGAGTTTAGGTG
2961 TGTGTTATTATAAATAATGTTTAACTAAATAATAAAACATTATTTCATTACAATTATAATTATAAATATTGGTGTTTTGA
3041 TATTGAGAGATATTAGTGGTGTTTACTGTGGAAAATCTTAGTAAATATCATTCTGTGTACTAAAATCCTAACCTATTAAT
3121 AGGATGTGTGCCCTATGTCAGACAGTGTGCTAAGCATATTAACTATATTATCTCATTTAATCATCACAACAATCTGCTGG
3201 TTTGGACACTATTCTCTCTGGAGGCAATATGGATGAGTTCTTACGGATATGGGGTTTGGGGTCAGAAACATCTTGATTAA
3281 AATTTTGACTCTGCCATTTTCTAGCCCTTTTATGTTGGGAAAGCTACTTTTTCTAGTCTCAATTTCCTCATAATAAAATG
3361 AAAATCAATTATAAGATCGATTTCCATAGGGTTGTCATGAGTTTTGAGTAAAAATGTGTATGTAAAGTTCTTACCACAAT
3441 ACCTGGCAGAGAGTAAGTATTCAATTAATGTTAGCTATTATTATCATCATAATCGTTGTGTTAAATATATTGCCCAAGAT
3521 AATATGTGGGGGAATGTTTGTTTTATATGCATATTGTATCCTGACTGTGTGCAGAACACATTATGTGTATTGCATATATG
3601 TAAAAGAAGTGTACAAGGAAGTGGCCATCCTTGTTCAAGTTACGTATCTAGTTAGAACAACTTCCCAGTCCATTGGAGTT
3681 CTTTGAGAAGCCTCAGGGAAGTAGCTCTGGGTCCTTCTAATCAACCTCCCATTACTGCGCCAGTAAGTTTCTGTTTCTTA
3761 TAAATAAACTCTTTGCTATTCAGAAAACCTCAAGGGGCCCCCACATTCACTAAGCATGGGGCTCCTAACTGGGGTCCAGG
3841 TCCATAGAGTGTAGGAAGAACATATTAGAACAATACTTGTGCTTATTTTTATCTAGCTTTTTTATGTTTGTGTATGTTTT
3921 ATAATGGCATAATAGTACAATGGTACATGTACATAATTTTAAATAAATAAATGAATGAATGAATAAATAAAAAAAAAAAA
4001 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guggggguggUGGUGCGGGc 5'
                    ::||||||| 
Target 5' agagggaggaGTCACGCCCt 3'
 913 - 932 142.00 -13.30
2 
miRNA  3' guGGGGGUGGUGGUGCGGgc 5'
            |:||||::||::||||  
Target 5' acCTCCCATTACTGCGCCag 3'
 3724 - 3743 126.00 -25.90
3 
miRNA  3' gugGGGGUGGUGGUGCGGGc 5'
             |:| |||||||:| || 
Target 5' acaCTCAACCACCATGGCCg 3'
 1256 - 1275 125.00 -30.90
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1159018549 3 dbSNP
rs748934844 4 dbSNP
rs770689077 12 dbSNP
rs1159960744 13 dbSNP
rs1401849038 16 dbSNP
rs778745571 22 dbSNP
rs747156659 28 dbSNP
rs1331955708 29 dbSNP
rs1342001912 38 dbSNP
rs185957857 46 dbSNP
rs1287705390 50 dbSNP
rs1222467970 57 dbSNP
rs1056739726 87 dbSNP
rs1160794919 93 dbSNP
rs771116026 102 dbSNP
rs1374245982 112 dbSNP
rs200639149 117 dbSNP
rs1023350232 118 dbSNP
rs1416664552 126 dbSNP
rs1407254984 132 dbSNP
rs898167171 134 dbSNP
rs565271173 137 dbSNP
rs1022180034 146 dbSNP
rs995129317 153 dbSNP
rs1303879296 165 dbSNP
rs1025549364 166 dbSNP
rs903758483 185 dbSNP
rs1469636142 186 dbSNP
rs776892281 192 dbSNP
rs1179521825 200 dbSNP
rs1000609985 202 dbSNP
rs1306593398 203 dbSNP
rs1320968159 229 dbSNP
rs1269693997 230 dbSNP
rs1224007025 245 dbSNP
rs1349260057 254 dbSNP
rs951285845 259 dbSNP
rs1377905569 264 dbSNP
rs1031638866 265 dbSNP
rs956354589 274 dbSNP
rs986621367 277 dbSNP
rs1450987324 278 dbSNP
rs1391302133 289 dbSNP
rs1160014744 290 dbSNP
rs1400375569 301 dbSNP
rs1019886090 307 dbSNP
rs1165120397 319 dbSNP
rs1446336407 357 dbSNP
rs1243748003 365 dbSNP
rs201844568 367 dbSNP
rs1459769000 369 dbSNP
rs1345397569 374 dbSNP
rs191992870 375 dbSNP
rs976860734 377 dbSNP
rs1216018748 383 dbSNP
rs975242651 384 dbSNP
rs867663761 385 dbSNP
rs1446092898 387 dbSNP
rs1281501147 398 dbSNP
rs1256472715 401 dbSNP
rs1483959931 403 dbSNP
rs41297281 408 dbSNP
rs954181377 418 dbSNP
rs1314888451 419 dbSNP
rs1244424559 428 dbSNP
rs1439916603 437 dbSNP
rs776005679 447 dbSNP
rs200719633 461 dbSNP
rs910138234 468 dbSNP
rs1393673246 488 dbSNP
rs1454059495 491 dbSNP
rs1325605373 492 dbSNP
rs1425446000 496 dbSNP
rs1177468072 497 dbSNP
rs1384702139 502 dbSNP
rs941587889 503 dbSNP
rs972842943 510 dbSNP
rs1421330391 516 dbSNP
rs866451792 519 dbSNP
rs1186942675 522 dbSNP
rs1460577377 523 dbSNP
rs1240057290 525 dbSNP
rs1297672280 527 dbSNP
rs183864332 529 dbSNP
rs1224264192 532 dbSNP
rs918255686 533 dbSNP
rs188757017 545 dbSNP
rs939119730 553 dbSNP
rs1056126868 562 dbSNP
rs1490350393 567 dbSNP
rs778829630 570 dbSNP
rs763619084 597 dbSNP
rs947906329 599 dbSNP
rs368637471 600 dbSNP
rs1214415471 602 dbSNP
rs979421142 604 dbSNP
rs61739515 613 dbSNP
rs1405786455 632 dbSNP
rs1364995066 634 dbSNP
rs3827468 643 dbSNP
rs1422647615 645 dbSNP
rs1301955524 660 dbSNP
rs924219157 664 dbSNP
rs1427640633 676 dbSNP
rs1417129763 677 dbSNP
rs935586431 693 dbSNP
rs775651753 704 dbSNP
rs5979716 708 dbSNP
rs1196701647 713 dbSNP
rs1256855906 716 dbSNP
rs1252466140 721 dbSNP
rs891777226 723 dbSNP
rs1306060849 733 dbSNP
rs998707099 736 dbSNP
rs1457777664 740 dbSNP
rs1224309344 748 dbSNP
rs1345174100 751 dbSNP
rs1281422543 754 dbSNP
rs1393287370 761 dbSNP
rs1200149383 763 dbSNP
rs768652508 771 dbSNP
rs1298608871 777 dbSNP
rs750105350 783 dbSNP
rs1352491883 800 dbSNP
rs1469967742 801 dbSNP
rs776565263 802 dbSNP
rs1427921184 803 dbSNP
rs371017598 831 dbSNP
rs963328405 837 dbSNP
rs1170288194 844 dbSNP
rs765640378 862 dbSNP
rs1420294618 864 dbSNP
rs1250621279 870 dbSNP
rs995161922 872 dbSNP
rs1177096365 873 dbSNP
rs1479957513 874 dbSNP
rs1046694438 888 dbSNP
rs1204762432 894 dbSNP
rs918274621 895 dbSNP
rs1261567756 906 dbSNP
rs1241453881 918 dbSNP
rs750839794 934 dbSNP
rs1306407967 938 dbSNP
rs1390724412 939 dbSNP
rs1338449299 948 dbSNP
rs1453173780 960 dbSNP
rs1405099635 972 dbSNP
rs373274415 975 dbSNP
rs763368660 980 dbSNP
rs1008576307 989 dbSNP
rs1157799720 993 dbSNP
rs1324162221 994 dbSNP
rs1019493527 1008 dbSNP
rs1417824531 1020 dbSNP
rs1387708704 1021 dbSNP
rs1184581599 1025 dbSNP
rs1461095926 1028 dbSNP
rs964223371 1033 dbSNP
rs960415525 1036 dbSNP
rs1207066657 1037 dbSNP
rs780019218 1049 dbSNP
rs996691713 1050 dbSNP
rs1260187604 1059 dbSNP
rs1237057358 1068 dbSNP
rs1351398175 1105 dbSNP
rs1317000924 1106 dbSNP
rs1029527925 1107 dbSNP
rs1381722501 1110 dbSNP
rs1331976054 1114 dbSNP
rs749213060 1138 dbSNP
rs868505689 1144 dbSNP
rs1435548716 1147 dbSNP
rs991759266 1153 dbSNP
rs968114002 1161 dbSNP
rs1293891933 1173 dbSNP
rs916336232 1185 dbSNP
rs979486820 1188 dbSNP
rs1380473612 1203 dbSNP
rs923949227 1208 dbSNP
rs947774707 1211 dbSNP
rs1043576476 1212 dbSNP
rs1318043144 1216 dbSNP
rs1164727581 1217 dbSNP
rs1369050205 1218 dbSNP
rs754843220 1226 dbSNP
rs1219885618 1229 dbSNP
rs925139997 1233 dbSNP
rs1195828511 1236 dbSNP
rs1429333036 1239 dbSNP
rs935269320 1244 dbSNP
rs956656361 1251 dbSNP
rs1203625112 1254 dbSNP
rs778954293 1255 dbSNP
rs992819890 1257 dbSNP
rs1292634406 1259 dbSNP
rs747042558 1260 dbSNP
rs765270239 1270 dbSNP
rs1282185663 1275 dbSNP
rs1229426532 1277 dbSNP
rs948254896 1281 dbSNP
rs1294340488 1284 dbSNP
rs901728548 1298 dbSNP
rs1366838454 1308 dbSNP
rs771062755 1318 dbSNP
rs767298788 1330 dbSNP
rs1193610714 1355 dbSNP
rs931084051 1358 dbSNP
rs1169994730 1368 dbSNP
rs1264465745 1397 dbSNP
rs1046771670 1398 dbSNP
rs886783897 1400 dbSNP
rs1191729486 1402 dbSNP
rs1481555860 1407 dbSNP
rs998206064 1410 dbSNP
rs376127724 1428 dbSNP
rs776764794 1428 dbSNP
rs1490165849 1430 dbSNP
rs746101593 1433 dbSNP
rs1287717547 1442 dbSNP
rs1051058258 1463 dbSNP
rs17321823 1467 dbSNP
rs1006977235 1471 dbSNP
rs1250568497 1476 dbSNP
rs775748627 1480 dbSNP
rs1041402039 1489 dbSNP
rs1017137015 1498 dbSNP
rs1403860272 1511 dbSNP
rs755690992 1516 dbSNP
rs1328859423 1517 dbSNP
rs1331383623 1522 dbSNP
rs763414683 1524 dbSNP
rs962895220 1525 dbSNP
rs994712642 1529 dbSNP
rs1396165653 1530 dbSNP
rs1169048407 1542 dbSNP
rs1471061799 1551 dbSNP
rs764496452 1554 dbSNP
rs1175786556 1558 dbSNP
rs997114937 1586 dbSNP
rs1477051269 1591 dbSNP
rs1234682362 1592 dbSNP
rs1183836124 1598 dbSNP
rs961204921 1601 dbSNP
rs1351410058 1603 dbSNP
rs991796059 1621 dbSNP
rs1196595254 1622 dbSNP
rs916241501 1632 dbSNP
rs1263312947 1654 dbSNP
rs774989491 1665 dbSNP
rs1342208392 1666 dbSNP
rs979134628 1677 dbSNP
rs925137325 1682 dbSNP
rs1341031239 1683 dbSNP
rs935191780 1686 dbSNP
rs879122369 1700 dbSNP
rs1401354832 1705 dbSNP
rs1290904516 1707 dbSNP
rs1377730820 1712 dbSNP
rs1336251733 1716 dbSNP
rs1413015448 1717 dbSNP
rs968509230 1717 dbSNP
rs763727469 1719 dbSNP
rs5978572 1720 dbSNP
rs1379675131 1721 dbSNP
rs1176714836 1723 dbSNP
rs367886593 1732 dbSNP
rs1243561761 1736 dbSNP
rs1216313542 1743 dbSNP
rs1440386833 1744 dbSNP
rs1000957086 1746 dbSNP
rs1223922524 1747 dbSNP
rs1031050311 1753 dbSNP
rs1287415133 1756 dbSNP
rs956958696 1763 dbSNP
rs750050137 1765 dbSNP
rs1446046649 1786 dbSNP
rs1347239898 1791 dbSNP
rs760437995 1798 dbSNP
rs1319047040 1799 dbSNP
rs757272446 1807 dbSNP
rs1358704831 1813 dbSNP
rs1185972064 1820 dbSNP
rs1446394287 1842 dbSNP
rs1385609858 1843 dbSNP
rs1181108197 1859 dbSNP
rs918192642 1866 dbSNP
rs201404463 1868 dbSNP
rs1243548113 1890 dbSNP
rs1051134086 1894 dbSNP
rs778688099 1903 dbSNP
rs942790114 1905 dbSNP
rs1283303431 1910 dbSNP
rs1183850649 1912 dbSNP
rs1360837514 1943 dbSNP
rs1312446428 1946 dbSNP
rs1038465636 1951 dbSNP
rs1364536778 1953 dbSNP
rs898547859 1956 dbSNP
rs1270922834 1959 dbSNP
rs1430314607 1975 dbSNP
rs1338458353 1982 dbSNP
rs1305085582 1986 dbSNP
rs1426440404 2005 dbSNP
rs1366188789 2006 dbSNP
rs1163792766 2007 dbSNP
rs994348787 2009 dbSNP
rs1421400718 2025 dbSNP
rs981406823 2025 dbSNP
rs766100707 2026 dbSNP
rs931448773 2029 dbSNP
rs1260363369 2031 dbSNP
rs982499075 2034 dbSNP
rs1157798702 2042 dbSNP
rs908297797 2052 dbSNP
rs896778589 2057 dbSNP
rs1013791867 2072 dbSNP
rs1310921084 2074 dbSNP
rs1358099237 2087 dbSNP
rs1220008264 2099 dbSNP
rs943738217 2102 dbSNP
rs1274175953 2108 dbSNP
rs1448058623 2109 dbSNP
rs1218222534 2111 dbSNP
rs1316339653 2116 dbSNP
rs1040704571 2134 dbSNP
rs1023283943 2169 dbSNP
rs745697687 2183 dbSNP
rs570437487 2197 dbSNP
rs1042959710 2206 dbSNP
rs1434259115 2211 dbSNP
rs904357294 2215 dbSNP
rs998683872 2216 dbSNP
rs191181705 2220 dbSNP
rs1421092376 2230 dbSNP
rs754856486 2242 dbSNP
rs1031125228 2246 dbSNP
rs182141680 2248 dbSNP
rs892538494 2264 dbSNP
rs979038094 2275 dbSNP
rs1481934661 2280 dbSNP
rs1032112263 2281 dbSNP
rs1198488093 2285 dbSNP
rs752633493 2290 dbSNP
rs1316281029 2295 dbSNP
rs1356229045 2306 dbSNP
rs1265168346 2309 dbSNP
rs1224361453 2310 dbSNP
rs1311640898 2317 dbSNP
rs956620278 2319 dbSNP
rs1299313719 2321 dbSNP
rs758143922 2325 dbSNP
rs923094513 2370 dbSNP
rs933247827 2372 dbSNP
rs980998718 2377 dbSNP
rs187103318 2398 dbSNP
rs910441239 2399 dbSNP
rs781270583 2415 dbSNP
rs1212312907 2420 dbSNP
rs1338247152 2431 dbSNP
rs982907623 2443 dbSNP
rs780256394 2444 dbSNP
rs1421393201 2456 dbSNP
rs1409431365 2477 dbSNP
rs1038736469 2494 dbSNP
rs17321830 2495 dbSNP
rs1245392690 2496 dbSNP
rs930044902 2515 dbSNP
rs1483077851 2518 dbSNP
rs1047268510 2523 dbSNP
rs768743535 2541 dbSNP
rs908331587 2558 dbSNP
rs943785731 2567 dbSNP
rs1317603313 2569 dbSNP
rs1309802730 2574 dbSNP
rs1441269289 2586 dbSNP
rs1239372799 2587 dbSNP
rs1374316438 2589 dbSNP
rs1316957729 2590 dbSNP
rs1396219466 2590 dbSNP
rs976885667 2590 dbSNP
rs920945829 2591 dbSNP
rs896642982 2599 dbSNP
rs1170764138 2628 dbSNP
rs1013822912 2631 dbSNP
rs1438410726 2632 dbSNP
rs1424345165 2645 dbSNP
rs1184641153 2651 dbSNP
rs1423445397 2660 dbSNP
rs1254266603 2673 dbSNP
rs1023855184 2677 dbSNP
rs1414582838 2678 dbSNP
rs1486211021 2679 dbSNP
rs905430178 2680 dbSNP
rs1000540190 2685 dbSNP
rs1215778927 2690 dbSNP
rs1032389859 2700 dbSNP
rs776819943 2712 dbSNP
rs1445599331 2713 dbSNP
rs988277221 2713 dbSNP
rs769972557 2717 dbSNP
rs1245317822 2722 dbSNP
rs1030193033 2723 dbSNP
rs1379617060 2728 dbSNP
rs1310054691 2734 dbSNP
rs904430460 2739 dbSNP
rs954540197 2757 dbSNP
rs1232489877 2758 dbSNP
rs1418379244 2772 dbSNP
rs1368083573 2778 dbSNP
rs985936562 2781 dbSNP
rs1457659115 2790 dbSNP
rs375347698 2794 dbSNP
rs749611217 2801 dbSNP
rs1221083399 2805 dbSNP
rs550160655 2808 dbSNP
rs1487260348 2809 dbSNP
rs1270887535 2827 dbSNP
rs974133753 2836 dbSNP
rs1355330610 2844 dbSNP
rs1199538231 2845 dbSNP
rs5979717 2851 dbSNP
rs1229134317 2854 dbSNP
rs1318204560 2855 dbSNP
rs1277019451 2863 dbSNP
rs762435507 2866 dbSNP
rs1196439714 2869 dbSNP
rs1047579817 2885 dbSNP
rs917971951 2895 dbSNP
rs1386726742 2906 dbSNP
rs1377066435 2908 dbSNP
rs771671251 2920 dbSNP
rs1174191566 2923 dbSNP
rs1045171436 2924 dbSNP
rs191553619 2931 dbSNP
rs1481421144 2935 dbSNP
rs1247397656 2948 dbSNP
rs1199429470 2966 dbSNP
rs1451019622 2973 dbSNP
rs1270787908 2974 dbSNP
rs1197409370 2994 dbSNP
rs1170986031 2998 dbSNP
rs1001521879 3003 dbSNP
rs1457927371 3007 dbSNP
rs1401982516 3008 dbSNP
rs1385498916 3014 dbSNP
rs1256970095 3020 dbSNP
rs1216440615 3044 dbSNP
rs1002158088 3045 dbSNP
rs1053478917 3050 dbSNP
rs1323292202 3056 dbSNP
rs1233136771 3082 dbSNP
rs760313561 3090 dbSNP
rs1329918539 3097 dbSNP
rs1331287362 3107 dbSNP
rs1332242045 3113 dbSNP
rs1027228423 3114 dbSNP
rs1439220640 3122 dbSNP
rs952954871 3123 dbSNP
rs535992529 3126 dbSNP
rs1268887935 3128 dbSNP
rs1471095483 3138 dbSNP
rs892112493 3148 dbSNP
rs1425919472 3153 dbSNP
rs1172113231 3157 dbSNP
rs1004363118 3166 dbSNP
rs1009205979 3168 dbSNP
rs1030102151 3175 dbSNP
rs1317410308 3191 dbSNP
rs41297293 3195 dbSNP
rs1007405773 3213 dbSNP
rs765930397 3221 dbSNP
rs1196334230 3225 dbSNP
rs1462417175 3227 dbSNP
rs963367314 3241 dbSNP
rs184379190 3245 dbSNP
rs759184893 3246 dbSNP
rs770362845 3262 dbSNP
rs868214978 3285 dbSNP
rs965893660 3288 dbSNP
rs1281723877 3292 dbSNP
rs1241533518 3310 dbSNP
rs976529962 3315 dbSNP
rs1307581405 3316 dbSNP
rs973712315 3318 dbSNP
rs919970561 3325 dbSNP
rs1360022357 3328 dbSNP
rs951476257 3342 dbSNP
rs1333582794 3359 dbSNP
rs1412760483 3360 dbSNP
rs1387268990 3363 dbSNP
rs1160347538 3369 dbSNP
rs1440285639 3373 dbSNP
rs921009063 3377 dbSNP
rs866093241 3387 dbSNP
rs1473573373 3388 dbSNP
rs1237626885 3398 dbSNP
rs1451908670 3401 dbSNP
rs918004855 3419 dbSNP
rs949438429 3422 dbSNP
rs1440148024 3428 dbSNP
rs1200940932 3436 dbSNP
rs773541470 3448 dbSNP
rs1217949640 3451 dbSNP
rs765091539 3452 dbSNP
rs1353680691 3458 dbSNP
rs925883499 3464 dbSNP
rs1193726325 3465 dbSNP
rs934581536 3469 dbSNP
rs1380351607 3484 dbSNP
rs746059889 3495 dbSNP
rs926774649 3495 dbSNP
rs917098631 3496 dbSNP
rs936966718 3506 dbSNP
rs1298936909 3508 dbSNP
rs1420220306 3511 dbSNP
rs1359898456 3529 dbSNP
rs1428317855 3535 dbSNP
rs1054458632 3540 dbSNP
rs1156781166 3552 dbSNP
rs1406820244 3560 dbSNP
rs1414286359 3561 dbSNP
rs892695558 3585 dbSNP
rs1471628074 3586 dbSNP
rs752580494 3588 dbSNP
rs1009647740 3593 dbSNP
rs1051393452 3601 dbSNP
rs1264677048 3608 dbSNP
rs949884550 3609 dbSNP
rs763426218 3612 dbSNP
rs758361000 3624 dbSNP
rs1456057154 3627 dbSNP
rs1224442667 3630 dbSNP
rs777727747 3634 dbSNP
rs1007311127 3645 dbSNP
rs1289671717 3652 dbSNP
rs1162205577 3671 dbSNP
rs1017474930 3674 dbSNP
rs188485142 3678 dbSNP
rs192900814 3679 dbSNP
rs1338538758 3681 dbSNP
rs1026668302 3682 dbSNP
rs141887737 3685 dbSNP
rs1280167936 3686 dbSNP
rs1338706970 3706 dbSNP
rs1004436508 3725 dbSNP
rs1322705108 3725 dbSNP
rs1244350639 3734 dbSNP
rs1425406652 3737 dbSNP
rs749540761 3739 dbSNP
rs768855769 3740 dbSNP
rs1420862578 3744 dbSNP
rs1356823666 3760 dbSNP
rs965612167 3767 dbSNP
rs1370709907 3772 dbSNP
rs998751431 3774 dbSNP
rs1028099704 3790 dbSNP
rs1283856237 3793 dbSNP
rs1487912674 3799 dbSNP
rs970808658 3800 dbSNP
rs980809337 3803 dbSNP
rs926681444 3819 dbSNP
rs936852757 3844 dbSNP
rs953757684 3846 dbSNP
rs1368287544 3848 dbSNP
rs1292723449 3872 dbSNP
rs1433945086 3883 dbSNP
rs1402207473 3898 dbSNP
rs1063992 3899 dbSNP
rs1331546491 3911 dbSNP
rs1421479176 3927 dbSNP
rs185856873 3936 dbSNP
rs1464819095 3942 dbSNP
rs978483548 3943 dbSNP
rs989622858 3953 dbSNP
rs775808697 3960 dbSNP
rs1475860569 3969 dbSNP
rs769146846 3970 dbSNP
rs1425001814 3972 dbSNP
rs766784674 3974 dbSNP
rs914145702 3982 dbSNP
rs147105568 3986 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000380682.1 | 3UTR | AGAAGAGGGAGGAGUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000380682.1 | 3UTR | AGAAGAGGGAGGAGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000380682.1 | 3UTR | AGAAGAGGGAGGAGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
40 hsa-miR-1268b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT473716 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT483653 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484276 AIP aryl hydrocarbon receptor interacting protein 2 4
MIRT486673 WDR81 WD repeat domain 81 2 2
MIRT488670 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT493452 ITFG3 family with sequence similarity 234 member A 2 2
MIRT495901 ZNF641 zinc finger protein 641 2 2
MIRT500187 BARX1 BARX homeobox 1 2 4
MIRT512014 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT521132 SGPL1 sphingosine-1-phosphate lyase 1 2 4
MIRT530046 TRIM72 tripartite motif containing 72 2 2
MIRT531518 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT543735 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT558053 EVI5L ecotropic viral integration site 5 like 2 2
MIRT569602 TRIM29 tripartite motif containing 29 2 2
MIRT570025 FAM228A family with sequence similarity 228 member A 2 2
MIRT573593 CERS1 ceramide synthase 1 2 2
MIRT623883 FRMPD4 FERM and PDZ domain containing 4 2 2
MIRT629999 PDE6B phosphodiesterase 6B 2 2
MIRT632715 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT633496 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT637075 SELPLG selectin P ligand 2 2
MIRT638182 TLN1 talin 1 2 2
MIRT638766 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT668072 GMPS guanine monophosphate synthase 2 2
MIRT669873 RAET1E retinoic acid early transcript 1E 2 2
MIRT670663 KIAA1551 KIAA1551 2 2
MIRT671282 RPL37A ribosomal protein L37a 2 2
MIRT675054 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT682783 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT683343 SCARF1 scavenger receptor class F member 1 2 2
MIRT690282 ZNF154 zinc finger protein 154 2 2
MIRT695171 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695221 SCAMP3 secretory carrier membrane protein 3 2 2
MIRT700484 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700600 PRKCA protein kinase C alpha 2 2
MIRT701409 NKRF NFKB repressing factor 2 2
MIRT703994 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT711231 RETSAT retinol saturase 2 2
MIRT719509 TMEM175 transmembrane protein 175 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1268b Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-1268b Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-1268b Cytoxan + Pirarubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Cytoxan + Doxorubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Cytoxan + Epirubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Doxorubicin + Taxol sensitive High Breast Cancer tissue
hsa-miR-1268b Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-1268b Anthracycline 30323 NSC82151 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Cyclophosphamide 2907 NSC26271 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Fluorouracil 3385 NSC19893 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Taxol 36314 NSC125973 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Methotrexate 126941 NSC740 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-mir-1268b Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-1268b Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1268b Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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