miRTarBase - #MIRT624086


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pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DPP8   
Synonyms DP8, DPRP-1, DPRP1, MST097, MSTP097, MSTP135, MSTP141
Description dipeptidyl peptidase 8
Transcript NM_017743   
Other Transcripts NM_130434 , NM_197960 , NM_197961   
Expression
Putative miRNA Targets on DPP8
3'UTR of DPP8
(miRNA target sites are highlighted)		 
>DPP8|NM_017743|3'UTR
   1 TTTTGACCTGTGTAGAACTCTCTGGTATACACTGGCTATTTAACCAAATGAGGAGGTTTAATCAACAGAAAACACAGAAT
  81 TGATCATCACATTTTGATACCTGCCATGTAACATCTACTCCTGAAAATAAATGTGGTGCCATGCAGGGGTCTACGGTTTG
 161 TGGTAGTAATCTAATACCTTAACCCCACATGCTCAAAATCAAATGATACATATTCCTGAGAGACCCAGCAATACCATAAG
 241 AATTACTAAAAAAAAAAAAAAAAAAAAGACATTAGCACCATGTATTCATACTACCCTATTTTCACTTTTAATAGTATTAT
 321 AAACTTCATGAACTTAATTAGTGTATTTTTACAGTATACTTTTGAGTTTGTTAAAATATGATGATATTAGTGATTGGTTT
 401 GGTTCAGTTCCAGAATCTTTGACTAGTTACAGATTTGATAGCACTTAAATGTAATTGAATAGCTTATGCTTCATTGCTTG
 481 GGCATATCCAGCATGTTATGAACTAATAACTATTAAACTTGACTTAACCAGTCATTCATTAATAATTTTTCAAGGATAAC
 561 TTAGTGGCCTCCTAAAGACACTTGTTTTGGCACTGACCAGTTTTTAGCCAATTTAATCTGTATCTAGTATAAATAATTCT
 641 CATTTTTCTTTGATGATATTAACAGAGTGGGCTTTTCCTTTTGCATAAAGGCTAGTAACTGTATATGTAGCATGGATTTA
 721 ATTAGTCATGATATTGATAATTACAGGCAGAAAATTTTTAATCAAATGATTAGAGCTTAAATATTTGCAGGCAAGTTTTT
 801 TTTTTTCCTTTAAGAAAAGGAAAAAGTACACATTCACTAGAATTCTTCAGAAAATTTAGTGGTGCCAGTTTCCATTTGGT
 881 ATTTCCTTATTAAAATATTCTAGAATTTTAAGGAGATTGAAGGGAATCACAGTGGGGTGGGGAGACCTGGGTTTGGGGAA
 961 TGACAGAGAGAAGAGGTGGTGAGGGCCTGATTAAAAACTAAGCAGAAGTAGTTTTAACAAAAATACTCATGAAAATGTTT
1041 GGAAACTGAAATTTAAACAACTGTAATATTAAGGAAACCAGAATCAATAAATCACTGTCTTGCCAGCACAGCTACAGAGT
1121 AACATGATTCAGGGGAGGAAAAGTTCCTTAGAGTTACTTTTATAATTCTTTTTTTTTTTCCTCTTAGGTTTAGAAATCTT
1201 ACAAATTTAAACTTTATCCTTTTAAAATTATTTGAACATAATTTAGATATTGTAAGCTTAAAATACAAATGTTTATAGAT
1281 AACCTCTTTACCATAAACTAATCCCTGGCAAGCCATGGCTCTCTTTTTTTTTTTGGTGTTTAAAGCCTGTAAACAGTTTT
1361 TCTGAATGATCATGAACTTTTCTTGGTTTAGCACTAGGATTTAGCTATGAAGAGAGCTCATAGGCTTTCAGGTGCTAATT
1441 GAGATCTGCCCTGTTAGAGTCTTGGGGTGCTAGATTGGTCACATTGACACCAGTGGCAGGGAAGGCATCTATGAGTTTGA
1521 TGCTTTTTATCACACACTTCAGTGTTTAGAAAGTTATTACCAATACTTTTAAACAACACTCCAAGAAAATTTGCTATATT
1601 TCTTTCTCATCACTACAGAGAGAGTAGATTTCCCCATAGAGAGCACAGCCTCCATTAGTAAGGTTGGTGACTATTGGTAA
1681 GAGGTGGACTTCATTGACACCAAGTGGGAGGTAGGGAAAGCCCAGAAATGGCAGGATGATATGGTGGTTCTGTCGTTGGG
1761 AAAGGTATTGGGTTTTGCTGTTTGTATTTATACTGTATAATAGATACCACGCTTTTTCTTATTATCTGTATATGTATTGC
1841 TTTTCATGTTTGATATTTTCCCATGCCAAGATTTGTTTATATATATTTTCAATGTTAAATTAAATTGATTTGGGTAACTT
1921 TCTTCCCCAAGAAAGTATTTTCCCCCTTAAGTATATATCTGACTGTGGAGGGTGTTTTGTTTTGTTTTGTTTTGTTTTGT
2001 TTGGACTAACTGGCCTCGAAGGATCTATCCTTATAATATATGCAAAGTAGAAATGGTATACAGTAGCTTTTAAGCAGCTA
2081 CTCCATTGAAACCTCTCACCCATTAAGGCTGTTTCTTCAAAGTGGCATCTCTTATTTTACCGAAACAAACTTAGAAAACT
2161 TCATGTACTCTGGAGTTCACAGGTGTTTTCCTTTTGCATGTTGCCTTCTCCTTTCCTCCTATCACAAAGAATGCTTCTAT
2241 TATCACTCCCAGTCACTTAAATGCCATTCTGCTTCTTTAGCAGGAAAAAATACCTGAATGAATTCTCTTACAGAAAGACA
2321 GTTTGACTGAATTTGCTTTTTACAATCAGTGTGGAAAATATCATAGTCAATTGAGGCAATCAGTAGAAATCTCACTAAAA
2401 GTTTGTACCCCCTGAGTATGGGTAACAGCTTAAACGGCAAGAATATATAAAAGTAGCAACAGTTTAGTGGGAGCCAAAAA
2481 GCACTAGGTTAAATATCATACTACGTTTTTAAAGACTTGATAAATGTGTACACTTGAACAACCATCCAGAGGGATAGTTA
2561 CTTGAGCATTACAGAGTAGTGGAACTCAAAATCTAAGATTCATCTGGGATACTTCTAAAAGAAATGTAGAGTTTTGAATC
2641 TCACTCTTAAAAATGTGTATTCCCAGGCTAGGCATGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGCGG
2721 GTGAATCACTTGAAGTCAGGAGATCAAGACCAGCTTGGTCGACATGGTGAAACCCCGTCTCTACTAAAAGTACAAAAAAA
2801 TTAGCTGGGCATGATGGCGTGTGCCTATAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGG
2881 CGGAAGTTGCAGTGAGCCGAGATGGCGCCACTGTAGTCCAGTCTGGGCGACAGAGTGAGATTCTGCCTCAAAATAAATAA
2961 ATAAATAAAAATTTGTATTCCATTGATTTGGGTAGACACCAGGAATGTGCATTTCTAACAAGCTTTCCAGGCGATCCTAT
3041 AGTAAGTCATCTGTGGACTACTTTAAGAAACTCTTCTATAGAGAATGGAGTTGGATTAATAATAGGTGATTTTTTACACT
3121 GGACTGATTCACAAGAACCTAAACAGTAGTCCATGAAGCTGCTCATCTGTGGTAACTATTTGGCCCCGTCTCACTCTGAA
3201 AGCAGCAGGAGATGTTGTTTACTTTGTTTCTATCCCCTTTGTCTGGAGATTAATTTTGGAATGAAAGTTTTTCTCTCTAT
3281 GCCATTCCTGGTTCTTTTCCAAAGCCTCATACAAGAGGATTAGGTCACAATGCATGCATTACCTTTTAAAAGAATGCGAT
3361 ATTGATACCGATGCTTACTTTTTTTTTTTTACTACTTGTTTTATTCCTTCCAGAAAGTATAGCCCGCCTTTCTATAGCAT
3441 AGTTCTCTTTAGGTGGAATGATTCCTATAAGATTTCTCATTATTAAATCATGCATTTTTCAAGATGGAATCAATATTTGA
3521 TTTAATCTAAGCTGATATTCTCATTTGTTAGAAGAACAACCTACATGCTAGAGAGAGAGGAGGAAATATACCCACGACCA
3601 CACAGCCAGTTAGTATCCAGTTGGTGCTGGACTCCAGCCAGGTGTCCTGCCTCATGGTAGTTAAATGATATATAGAAAAG
3681 GTAAATTTTTAAAGAAATATTTATTAATATATTCCTATAAAACATTTTAAAGGTAACCACATAAAAATGGTTAATTTTTC
3761 CATTCCAAAGTAAATGCTAAGCATGTTTATTAATGAAGCAGTACTTCTGATTAGTATATGACATTCTGAAGTTAATTAAA
3841 CTCATTGCACTAAATGTGTCTTCCTTGGTATAGTGGAGGATTTGAGGATTGGAATATAGAGTAGAGTGCTTGCTTAAGCC
3921 TGGGAGCCCATCTTTATAGCTATTTGATGTAAGAAAAGAGACATGGCCATTTCTAAACTATATAAGGTGAGTGTGTCTAT
4001 TCCCAGCAGATATAAAGGAAAAAGGAAACTTTTTTGATTCCCACCTTCCCAGCCTCACCTAGCCATCTTCCAGCCTCAAA
4081 TATAGAGATGTTAGTGCAAGGTCCTGGGCTCTAGGTGATCATTTCATAAGTCCTTTACAGATAAAGAAAAAGTAGTGTTT
4161 GTATGTTTGTTTTTAAGTAACCCCAAAACAAATTTATATTGTATTCAGCAAAATTGGAATTCAGGTGTTTAATTTTAGAA
4241 CATGAAGTGCCTGCTGTTTTAAGCATTGACTTGTATAAAAAGAATTGCATGTCTCCAGTAAGCTTATGGGTTTTCTCATT
4321 TTTAGGTATATGGCTTTTAATCATGTAAAGTGAAACATTAGTTTTCTTGCATTTTATTACAGGTTCTTTGTTGCAATAAA
4401 GATGCTGCTGAAATTAATTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            :|::| ||||||||||||  
Target 5' atGGTGAAACCCCGTCTCTAct 3'
 2764 - 2785 160.00 -21.80
2 
miRNA  3' ucUCGUUCUGGGGC--AGAGAUUu 5'
            | ||:|| : :|  |:||||| 
Target 5' acACCAGGAATGTGCATTTCTAAc 3'
 2996 - 3019 138.00 -8.20
3 
miRNA  3' ucucgUUCUG---GGGCAGAGAUUu 5'
               :||||    || |:||||| 
Target 5' gaaaaGAGACATGGCCATTTCTAAa 3'
 3953 - 3977 137.00 -15.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31576609 7 COSMIC
COSN28193942 12 COSMIC
COSN31599499 13 COSMIC
COSN30109750 22 COSMIC
COSN24879656 25 COSMIC
COSN30145553 44 COSMIC
COSN7246557 45 COSMIC
COSN30187716 55 COSMIC
COSN31607906 77 COSMIC
COSN30474839 85 COSMIC
COSN8389862 85 COSMIC
COSN31613609 99 COSMIC
COSN31526937 100 COSMIC
COSN31532555 147 COSMIC
COSN31611907 182 COSMIC
COSN20078231 237 COSMIC
COSN17984303 240 COSMIC
COSN7246556 498 COSMIC
COSN6544766 670 COSMIC
COSN18834649 708 COSMIC
COSN27983415 755 COSMIC
COSN27508693 795 COSMIC
COSN27231546 1169 COSMIC
COSN31527031 1218 COSMIC
COSN28934198 1324 COSMIC
COSN28758662 1397 COSMIC
COSN21302156 1603 COSMIC
COSN20992698 2694 COSMIC
COSN21201372 2948 COSMIC
COSN25667938 3647 COSMIC
COSN4762831 3709 COSMIC
COSN29891442 3726 COSMIC
COSN19244223 3937 COSMIC
COSN17406999 3975 COSMIC
COSN29424181 4242 COSMIC
rs72739469 1142 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs573288658 8 dbSNP
rs755521525 12 dbSNP
rs1184963077 15 dbSNP
rs1428728121 17 dbSNP
rs200136339 19 dbSNP
rs1479513578 20 dbSNP
rs778720406 21 dbSNP
rs1261033503 22 dbSNP
rs757174516 29 dbSNP
rs1345633726 31 dbSNP
rs749388995 32 dbSNP
rs777805510 33 dbSNP
rs1453416499 36 dbSNP
rs756398941 38 dbSNP
rs752905406 45 dbSNP
rs1383501328 48 dbSNP
rs367764223 50 dbSNP
rs916383441 53 dbSNP
rs936841532 55 dbSNP
rs538500587 56 dbSNP
rs1303199726 57 dbSNP
rs1344280731 61 dbSNP
rs1221177334 63 dbSNP
rs1362959704 64 dbSNP
rs1317516355 65 dbSNP
rs1269330456 73 dbSNP
rs992006067 80 dbSNP
rs960638455 83 dbSNP
rs918527857 86 dbSNP
rs569364372 106 dbSNP
rs972419334 110 dbSNP
rs552695472 125 dbSNP
rs1489862311 126 dbSNP
rs1016559353 127 dbSNP
rs1409352460 131 dbSNP
rs752091928 140 dbSNP
rs1006562259 143 dbSNP
rs1432655412 144 dbSNP
rs545282060 152 dbSNP
rs953812165 153 dbSNP
rs1029095712 154 dbSNP
rs1460906584 155 dbSNP
rs539137842 164 dbSNP
rs567017672 168 dbSNP
rs1402549423 185 dbSNP
rs1299441210 188 dbSNP
rs1373938428 189 dbSNP
rs1390786397 196 dbSNP
rs997661421 212 dbSNP
rs1347585708 232 dbSNP
rs1171952026 234 dbSNP
rs1410142675 235 dbSNP
rs1418378199 237 dbSNP
rs879713354 240 dbSNP
rs879316822 243 dbSNP
rs879907718 244 dbSNP
rs1255349368 245 dbSNP
rs1194781852 246 dbSNP
rs879494603 247 dbSNP
rs1263714474 267 dbSNP
rs1246452166 268 dbSNP
rs1258905562 268 dbSNP
rs1291221599 268 dbSNP
rs1357650737 268 dbSNP
rs397969608 268 dbSNP
rs762729059 268 dbSNP
rs995896556 268 dbSNP
rs1445557627 269 dbSNP
rs902078148 269 dbSNP
rs1053148961 270 dbSNP
rs1206739532 270 dbSNP
rs999528873 271 dbSNP
rs188511480 287 dbSNP
rs909276568 288 dbSNP
rs984911900 292 dbSNP
rs1349770556 305 dbSNP
rs952567378 314 dbSNP
rs1384906352 317 dbSNP
rs1043753029 321 dbSNP
rs1303945702 325 dbSNP
rs1453100081 326 dbSNP
rs1314190196 327 dbSNP
rs150756239 328 dbSNP
rs916684812 329 dbSNP
rs980690398 340 dbSNP
rs371133931 341 dbSNP
rs531448692 341 dbSNP
rs373107550 375 dbSNP
rs1056297835 376 dbSNP
rs1202541846 382 dbSNP
rs1353493799 386 dbSNP
rs1462200806 386 dbSNP
rs142093094 397 dbSNP
rs1241726097 415 dbSNP
rs892173268 423 dbSNP
rs1436253536 430 dbSNP
rs183264290 432 dbSNP
rs1427335075 437 dbSNP
rs530793509 440 dbSNP
rs1408197219 443 dbSNP
rs1470293216 452 dbSNP
rs763794538 465 dbSNP
rs1403586778 466 dbSNP
rs1432667467 471 dbSNP
rs1270934363 473 dbSNP
rs1174691871 482 dbSNP
rs962668010 483 dbSNP
rs889249427 503 dbSNP
rs1324854842 507 dbSNP
rs1203544377 510 dbSNP
rs1261837482 512 dbSNP
rs1449040202 525 dbSNP
rs909525998 536 dbSNP
rs755348958 537 dbSNP
rs1178953820 544 dbSNP
rs1242330926 544 dbSNP
rs576285986 553 dbSNP
rs1190856379 555 dbSNP
rs1232435818 560 dbSNP
rs1203261126 564 dbSNP
rs751177586 572 dbSNP
rs1480498009 573 dbSNP
rs1350379120 574 dbSNP
rs1427133484 576 dbSNP
rs1280733864 589 dbSNP
rs1233323100 596 dbSNP
rs564935088 597 dbSNP
rs1318802152 598 dbSNP
rs1344807696 600 dbSNP
rs544853589 602 dbSNP
rs1428934604 611 dbSNP
rs1305218981 616 dbSNP
rs1346174488 626 dbSNP
rs1222993829 627 dbSNP
rs953776494 641 dbSNP
rs1353550004 650 dbSNP
rs1309063352 651 dbSNP
rs933558118 659 dbSNP
rs902078571 666 dbSNP
rs1036638300 667 dbSNP
rs1371952956 668 dbSNP
rs940670111 671 dbSNP
rs35541372 673 dbSNP
rs909245603 703 dbSNP
rs749827941 705 dbSNP
rs1416198334 708 dbSNP
rs1375700065 709 dbSNP
rs1471152946 721 dbSNP
rs1158897198 733 dbSNP
rs1406922760 742 dbSNP
rs780377634 744 dbSNP
rs191075716 758 dbSNP
rs966648780 768 dbSNP
rs1031171111 780 dbSNP
rs1366430202 790 dbSNP
rs937441301 796 dbSNP
rs1301432657 798 dbSNP
rs1338030185 799 dbSNP
rs1443616938 804 dbSNP
rs1248645207 807 dbSNP
rs879086611 807 dbSNP
rs926449645 807 dbSNP
rs1376347242 819 dbSNP
rs1359793355 820 dbSNP
rs1221076745 823 dbSNP
rs1264701065 830 dbSNP
rs1161903090 836 dbSNP
rs1000151750 837 dbSNP
rs1439076034 841 dbSNP
rs981001646 849 dbSNP
rs688316 850 dbSNP
rs1420259093 858 dbSNP
rs904117886 859 dbSNP
rs1411293452 862 dbSNP
rs34121578 864 dbSNP
rs1386074760 866 dbSNP
rs1024847033 868 dbSNP
rs988054195 881 dbSNP
rs750465664 883 dbSNP
rs895223918 890 dbSNP
rs114178009 891 dbSNP
rs1334516184 893 dbSNP
rs1454915534 898 dbSNP
rs1427524939 899 dbSNP
rs1199598077 900 dbSNP
rs1244737773 916 dbSNP
rs1482150988 928 dbSNP
rs939455433 936 dbSNP
rs1195875646 937 dbSNP
rs1272194391 938 dbSNP
rs1031968132 940 dbSNP
rs1205301016 943 dbSNP
rs1000595546 949 dbSNP
rs896948118 953 dbSNP
rs1036881505 955 dbSNP
rs1216370221 961 dbSNP
rs373337986 964 dbSNP
rs1185632001 966 dbSNP
rs888875070 972 dbSNP
rs1028770236 978 dbSNP
rs941253188 982 dbSNP
rs909828760 983 dbSNP
rs1398722436 990 dbSNP
rs998074147 994 dbSNP
rs1337994774 995 dbSNP
rs1405747245 1003 dbSNP
rs1450928599 1011 dbSNP
rs902051443 1016 dbSNP
rs1327898016 1020 dbSNP
rs1393989367 1029 dbSNP
rs1400493472 1030 dbSNP
rs765551813 1034 dbSNP
rs932351776 1059 dbSNP
rs1263706637 1063 dbSNP
rs922351881 1063 dbSNP
rs976867405 1066 dbSNP
rs573575965 1072 dbSNP
rs761915887 1094 dbSNP
rs1049542869 1095 dbSNP
rs556879165 1096 dbSNP
rs1421629873 1134 dbSNP
rs72739469 1142 dbSNP
rs1177707768 1145 dbSNP
rs1476231181 1160 dbSNP
rs1464852039 1162 dbSNP
rs1297236720 1180 dbSNP
rs71901540 1180 dbSNP
rs878913059 1180 dbSNP
rs1418752041 1181 dbSNP
rs1187076507 1183 dbSNP
rs1045855240 1187 dbSNP
rs949236491 1188 dbSNP
rs1230776721 1198 dbSNP
rs749952843 1198 dbSNP
rs968271198 1201 dbSNP
rs1022589023 1202 dbSNP
rs1204722233 1204 dbSNP
rs28575576 1205 dbSNP
rs1263534148 1207 dbSNP
rs1012251804 1215 dbSNP
rs987981936 1222 dbSNP
rs956638155 1249 dbSNP
rs1431992293 1250 dbSNP
rs1161689735 1265 dbSNP
rs924918782 1268 dbSNP
rs11455 1276 dbSNP
rs1157617240 1278 dbSNP
rs1035036482 1279 dbSNP
rs1464339706 1292 dbSNP
rs539279988 1293 dbSNP
rs187728498 1303 dbSNP
rs1334900236 1304 dbSNP
rs553530577 1318 dbSNP
rs1317230186 1321 dbSNP
rs897258191 1328 dbSNP
rs1037256135 1332 dbSNP
rs1005109118 1335 dbSNP
rs566772552 1335 dbSNP
rs879720231 1335 dbSNP
rs1242127945 1336 dbSNP
rs1327864720 1338 dbSNP
rs941230442 1339 dbSNP
rs1383142411 1345 dbSNP
rs1177237952 1350 dbSNP
rs1378086027 1366 dbSNP
rs1426215387 1367 dbSNP
rs536710603 1371 dbSNP
rs1348754130 1372 dbSNP
rs888353537 1380 dbSNP
rs567562138 1385 dbSNP
rs1049343249 1390 dbSNP
rs1463530008 1400 dbSNP
rs1374052600 1403 dbSNP
rs1445756030 1405 dbSNP
rs1395269508 1407 dbSNP
rs1385218818 1416 dbSNP
rs1246933958 1419 dbSNP
rs1312305239 1432 dbSNP
rs550905522 1436 dbSNP
rs369369442 1437 dbSNP
rs905898834 1439 dbSNP
rs530810093 1454 dbSNP
rs1480627191 1459 dbSNP
rs771842139 1461 dbSNP
rs1322358980 1466 dbSNP
rs1197119415 1469 dbSNP
rs182316752 1470 dbSNP
rs571559835 1472 dbSNP
rs1445653324 1486 dbSNP
rs1183772532 1488 dbSNP
rs1046200718 1490 dbSNP
rs1375014367 1496 dbSNP
rs1421536515 1498 dbSNP
rs551248407 1499 dbSNP
rs1355015467 1505 dbSNP
rs932571231 1510 dbSNP
rs759155789 1512 dbSNP
rs1329262460 1514 dbSNP
rs922235909 1523 dbSNP
rs1246021877 1529 dbSNP
rs1195407026 1530 dbSNP
rs1052230672 1531 dbSNP
rs1468894920 1535 dbSNP
rs935192230 1542 dbSNP
rs976457976 1543 dbSNP
rs979411777 1546 dbSNP
rs528299972 1547 dbSNP
rs1296446949 1548 dbSNP
rs1317813303 1549 dbSNP
rs773723683 1554 dbSNP
rs1217297220 1557 dbSNP
rs572347696 1563 dbSNP
rs1461992049 1564 dbSNP
rs978657769 1566 dbSNP
rs770667409 1569 dbSNP
rs1209937510 1573 dbSNP
rs953153416 1574 dbSNP
rs748910400 1575 dbSNP
rs1022475430 1577 dbSNP
rs1187730207 1580 dbSNP
rs1340970218 1585 dbSNP
rs1419552282 1596 dbSNP
rs991037034 1597 dbSNP
rs1251536571 1600 dbSNP
rs1431362071 1616 dbSNP
rs976198320 1620 dbSNP
rs959625670 1622 dbSNP
rs1014711799 1625 dbSNP
rs965798497 1625 dbSNP
rs1227299849 1627 dbSNP
rs74420017 1636 dbSNP
rs1003571986 1637 dbSNP
rs961749530 1641 dbSNP
rs1443702397 1646 dbSNP
rs1339871161 1648 dbSNP
rs753764520 1652 dbSNP
rs1398247608 1664 dbSNP
rs557912889 1673 dbSNP
rs1372387304 1675 dbSNP
rs1015709923 1684 dbSNP
rs1322905806 1689 dbSNP
rs1218983589 1691 dbSNP
rs777364576 1693 dbSNP
rs1028315977 1694 dbSNP
rs1217427217 1696 dbSNP
rs1005337114 1704 dbSNP
rs1263468546 1712 dbSNP
rs1487639315 1714 dbSNP
rs1001804167 1717 dbSNP
rs905821537 1724 dbSNP
rs888238946 1727 dbSNP
rs190949344 1742 dbSNP
rs1429400746 1746 dbSNP
rs1388059691 1754 dbSNP
rs369951126 1755 dbSNP
rs528940416 1756 dbSNP
rs1377016154 1757 dbSNP
rs1196050227 1765 dbSNP
rs1281052031 1767 dbSNP
rs769032480 1771 dbSNP
rs1250686457 1775 dbSNP
rs1203974701 1784 dbSNP
rs935161162 1786 dbSNP
rs934372135 1787 dbSNP
rs1273599397 1788 dbSNP
rs924353807 1790 dbSNP
rs1481886168 1806 dbSNP
rs1272869598 1807 dbSNP
rs1375905972 1807 dbSNP
rs563137383 1810 dbSNP
rs116642941 1811 dbSNP
rs1352608543 1821 dbSNP
rs1213802960 1830 dbSNP
rs186401643 1832 dbSNP
rs1451707365 1840 dbSNP
rs577556107 1846 dbSNP
rs959595059 1849 dbSNP
rs140300252 1852 dbSNP
rs147132680 1861 dbSNP
rs1368974198 1863 dbSNP
rs1314428947 1868 dbSNP
rs961438013 1883 dbSNP
rs1016011617 1885 dbSNP
rs1005556602 1894 dbSNP
rs1170729920 1899 dbSNP
rs907623142 1901 dbSNP
rs1471148106 1907 dbSNP
rs1356861413 1923 dbSNP
rs867212579 1942 dbSNP
rs1028089257 1947 dbSNP
rs1180855660 1953 dbSNP
rs952159013 1954 dbSNP
rs1027826998 1965 dbSNP
rs763897976 1971 dbSNP
rs1439540049 1975 dbSNP
rs996658436 1977 dbSNP
rs775692334 1978 dbSNP
rs1471371501 1981 dbSNP
rs980740063 1989 dbSNP
rs538900400 2003 dbSNP
rs755285125 2003 dbSNP
rs774981434 2003 dbSNP
rs970346458 2003 dbSNP
rs1369272512 2004 dbSNP
rs1472505455 2007 dbSNP
rs1161598599 2010 dbSNP
rs1041005442 2018 dbSNP
rs1422248295 2024 dbSNP
rs1466644031 2024 dbSNP
rs1259183781 2027 dbSNP
rs999181688 2030 dbSNP
rs1331301922 2041 dbSNP
rs902815333 2044 dbSNP
rs1398496141 2045 dbSNP
rs1454931353 2048 dbSNP
rs1338221492 2055 dbSNP
rs1340772059 2061 dbSNP
rs573494523 2061 dbSNP
rs1281962197 2068 dbSNP
rs1340900251 2082 dbSNP
rs1443336881 2093 dbSNP
rs1257358973 2097 dbSNP
rs1042759325 2109 dbSNP
rs553565121 2119 dbSNP
rs1257105703 2120 dbSNP
rs1442111509 2123 dbSNP
rs1185473489 2124 dbSNP
rs1374829976 2125 dbSNP
rs1478202404 2126 dbSNP
rs1353513307 2134 dbSNP
rs536351225 2135 dbSNP
rs1055289425 2141 dbSNP
rs938197300 2142 dbSNP
rs567795380 2143 dbSNP
rs928201405 2153 dbSNP
rs1395049275 2159 dbSNP
rs982344750 2162 dbSNP
rs961936501 2164 dbSNP
rs1327617542 2169 dbSNP
rs1400084440 2174 dbSNP
rs1348790231 2177 dbSNP
rs1277480361 2190 dbSNP
rs1316050905 2192 dbSNP
rs908509929 2194 dbSNP
rs143745769 2198 dbSNP
rs1344075221 2199 dbSNP
rs1449107298 2203 dbSNP
rs1198896981 2216 dbSNP
rs952779144 2218 dbSNP
rs1028392256 2220 dbSNP
rs1331994255 2229 dbSNP
rs537490140 2239 dbSNP
rs1261640153 2251 dbSNP
rs181116969 2255 dbSNP
rs931836395 2265 dbSNP
rs965203210 2267 dbSNP
rs1157684815 2272 dbSNP
rs1019874700 2274 dbSNP
rs900399917 2282 dbSNP
rs998755425 2283 dbSNP
rs780678523 2290 dbSNP
rs1188190210 2291 dbSNP
rs1472282361 2297 dbSNP
rs551286968 2297 dbSNP
rs1040355272 2298 dbSNP
rs528334464 2305 dbSNP
rs565545723 2326 dbSNP
rs1021280172 2328 dbSNP
rs1338297854 2336 dbSNP
rs1011274179 2349 dbSNP
rs1301923674 2354 dbSNP
rs894219978 2361 dbSNP
rs1230803770 2362 dbSNP
rs907547685 2370 dbSNP
rs191590437 2397 dbSNP
rs938435366 2405 dbSNP
rs1215943079 2409 dbSNP
rs1269330803 2412 dbSNP
rs1491207894 2413 dbSNP
rs1491381207 2414 dbSNP
rs1490866407 2418 dbSNP
rs1192220811 2427 dbSNP
rs1267277578 2432 dbSNP
rs529071628 2435 dbSNP
rs1229073705 2436 dbSNP
rs1184494075 2437 dbSNP
rs371418504 2441 dbSNP
rs1381755115 2443 dbSNP
rs920734668 2448 dbSNP
rs1047015647 2453 dbSNP
rs1157711355 2456 dbSNP
rs1378746392 2462 dbSNP
rs539683189 2465 dbSNP
rs1459006513 2466 dbSNP
rs1293976205 2473 dbSNP
rs1282153914 2477 dbSNP
rs980279068 2479 dbSNP
rs1432641742 2484 dbSNP
rs1311250002 2498 dbSNP
rs1365744773 2504 dbSNP
rs774646867 2505 dbSNP
rs1307360371 2507 dbSNP
rs1323505158 2508 dbSNP
rs908823772 2524 dbSNP
rs1222488756 2525 dbSNP
rs984074022 2529 dbSNP
rs868191662 2533 dbSNP
rs1265358317 2536 dbSNP
rs1487819087 2537 dbSNP
rs1197891197 2538 dbSNP
rs543136194 2541 dbSNP
rs921266810 2544 dbSNP
rs1388337525 2547 dbSNP
rs1024508226 2550 dbSNP
rs975434071 2551 dbSNP
rs965857719 2556 dbSNP
rs1425041181 2561 dbSNP
rs1019418432 2568 dbSNP
rs956004882 2574 dbSNP
rs1411203768 2586 dbSNP
rs1161759293 2593 dbSNP
rs1476593152 2595 dbSNP
rs1333304456 2599 dbSNP
rs1249098992 2602 dbSNP
rs1400680823 2612 dbSNP
rs77141518 2617 dbSNP
rs564041737 2624 dbSNP
rs1021584946 2625 dbSNP
rs1329556492 2626 dbSNP
rs1381691203 2628 dbSNP
rs1463967034 2632 dbSNP
rs545726162 2638 dbSNP
rs1228938802 2640 dbSNP
rs1312147044 2642 dbSNP
rs1320033269 2645 dbSNP
rs773420637 2646 dbSNP
rs1220949914 2647 dbSNP
rs1259283877 2651 dbSNP
rs1317606091 2653 dbSNP
rs1000213403 2662 dbSNP
rs1235968738 2665 dbSNP
rs769805118 2668 dbSNP
rs1011241690 2671 dbSNP
rs1254925785 2678 dbSNP
rs1269987266 2680 dbSNP
rs1181906110 2681 dbSNP
rs1222418999 2681 dbSNP
rs757369522 2685 dbSNP
rs1034026173 2686 dbSNP
rs186273143 2699 dbSNP
rs549477888 2702 dbSNP
rs1424324404 2704 dbSNP
rs1464896787 2712 dbSNP
rs1168333233 2717 dbSNP
rs996020987 2718 dbSNP
rs1302511748 2719 dbSNP
rs576482534 2720 dbSNP
rs1401928989 2722 dbSNP
rs1279387243 2743 dbSNP
rs1317899367 2749 dbSNP
rs1217163747 2754 dbSNP
rs764350230 2757 dbSNP
rs181554086 2759 dbSNP
rs574138702 2760 dbSNP
rs1484400101 2764 dbSNP
rs1046542194 2776 dbSNP
rs1432755642 2777 dbSNP
rs1477476982 2784 dbSNP
rs940213213 2785 dbSNP
rs1426950225 2786 dbSNP
rs1293548337 2790 dbSNP
rs1175545600 2801 dbSNP
rs1357711185 2808 dbSNP
rs887353010 2810 dbSNP
rs867322798 2817 dbSNP
rs114859415 2818 dbSNP
rs930337431 2821 dbSNP
rs1347681188 2823 dbSNP
rs760554560 2827 dbSNP
rs1330460674 2832 dbSNP
rs1430062331 2833 dbSNP
rs921234296 2835 dbSNP
rs1300146052 2836 dbSNP
rs975837135 2838 dbSNP
rs944117514 2840 dbSNP
rs189590834 2842 dbSNP
rs577628849 2843 dbSNP
rs1044579259 2855 dbSNP
rs752434299 2862 dbSNP
rs1213487460 2864 dbSNP
rs767550888 2865 dbSNP
rs536271641 2870 dbSNP
rs1478230946 2881 dbSNP
rs967653297 2886 dbSNP
rs1190466162 2891 dbSNP
rs1423305514 2898 dbSNP
rs1441821122 2899 dbSNP
rs1361433360 2905 dbSNP
rs1326099125 2906 dbSNP
rs1417941024 2906 dbSNP
rs186361265 2907 dbSNP
rs914408956 2908 dbSNP
rs11545072 2909 dbSNP
rs1448139520 2910 dbSNP
rs958625890 2912 dbSNP
rs1397433788 2913 dbSNP
rs1192353160 2916 dbSNP
rs1379612906 2921 dbSNP
rs1033994100 2928 dbSNP
rs79743441 2929 dbSNP
rs1245103382 2936 dbSNP
rs202032147 2942 dbSNP
rs1015122731 2946 dbSNP
rs1291922042 2955 dbSNP
rs1452162542 2956 dbSNP
rs771744986 2958 dbSNP
rs1220522957 2959 dbSNP
rs1273587723 2966 dbSNP
rs1458945209 2969 dbSNP
rs924586305 2970 dbSNP
rs1379988026 2975 dbSNP
rs1468651234 2979 dbSNP
rs773953160 2992 dbSNP
rs770380797 2995 dbSNP
rs1301895453 2997 dbSNP
rs1322170802 2997 dbSNP
rs1048556769 2999 dbSNP
rs969162687 3003 dbSNP
rs1447992104 3005 dbSNP
rs1331607846 3007 dbSNP
rs1028398985 3011 dbSNP
rs1439368367 3017 dbSNP
rs11545071 3021 dbSNP
rs964536169 3032 dbSNP
rs1299424411 3033 dbSNP
rs900116200 3035 dbSNP
rs1369584733 3045 dbSNP
rs1271197003 3050 dbSNP
rs1039693822 3051 dbSNP
rs535673647 3054 dbSNP
rs1199096324 3057 dbSNP
rs1237773132 3059 dbSNP
rs1361320542 3068 dbSNP
rs569727879 3071 dbSNP
rs750147446 3075 dbSNP
rs1238073485 3080 dbSNP
rs1472516202 3080 dbSNP
rs138225485 3085 dbSNP
rs1426496788 3091 dbSNP
rs1423097375 3102 dbSNP
rs1170474124 3116 dbSNP
rs994512280 3119 dbSNP
rs898862867 3128 dbSNP
rs1044118714 3129 dbSNP
rs948478605 3130 dbSNP
rs1446733695 3137 dbSNP
rs1042152550 3138 dbSNP
rs796682484 3145 dbSNP
rs769431193 3147 dbSNP
rs1057243330 3158 dbSNP
rs946124423 3162 dbSNP
rs914381455 3172 dbSNP
rs1337229436 3184 dbSNP
rs934858490 3186 dbSNP
rs990003287 3187 dbSNP
rs149309496 3188 dbSNP
rs774540248 3193 dbSNP
rs1486524432 3194 dbSNP
rs1478458505 3195 dbSNP
rs968712599 3209 dbSNP
rs921265806 3212 dbSNP
rs1209297590 3215 dbSNP
rs559255716 3220 dbSNP
rs927232863 3231 dbSNP
rs1402538421 3241 dbSNP
rs747431946 3252 dbSNP
rs1433536361 3255 dbSNP
rs564074665 3259 dbSNP
rs868154484 3261 dbSNP
rs1228475311 3270 dbSNP
rs1349410325 3272 dbSNP
rs547463886 3277 dbSNP
rs1286056906 3279 dbSNP
rs971510508 3294 dbSNP
rs1275648054 3303 dbSNP
rs1344641327 3309 dbSNP
rs1008719377 3310 dbSNP
rs1288210230 3315 dbSNP
rs1488672840 3334 dbSNP
rs1014595253 3335 dbSNP
rs950571674 3341 dbSNP
rs1260270789 3348 dbSNP
rs775693485 3355 dbSNP
rs1200078622 3356 dbSNP
rs1303819468 3357 dbSNP
rs772671855 3362 dbSNP
rs1453377609 3364 dbSNP
rs1465934719 3369 dbSNP
rs951816367 3370 dbSNP
rs1419783243 3371 dbSNP
rs1357938106 3376 dbSNP
rs1027091408 3377 dbSNP
rs1426732742 3378 dbSNP
rs995172350 3379 dbSNP
rs527390958 3381 dbSNP
rs11406337 3391 dbSNP
rs1232307952 3391 dbSNP
rs1259460990 3391 dbSNP
rs398057762 3391 dbSNP
rs1180265130 3392 dbSNP
rs1425822790 3394 dbSNP
rs1256547721 3395 dbSNP
rs527268385 3400 dbSNP
rs1482203318 3410 dbSNP
rs1012639819 3420 dbSNP
rs1262417123 3423 dbSNP
rs900085073 3425 dbSNP
rs1040397542 3426 dbSNP
rs1439759427 3445 dbSNP
rs1157795533 3453 dbSNP
rs1361965098 3456 dbSNP
rs74021103 3458 dbSNP
rs542932832 3464 dbSNP
rs138582287 3467 dbSNP
rs1393387245 3468 dbSNP
rs1438453034 3469 dbSNP
rs1234699582 3471 dbSNP
rs1333615673 3473 dbSNP
rs946092042 3492 dbSNP
rs1390857917 3497 dbSNP
rs1043274267 3501 dbSNP
rs1340715543 3502 dbSNP
rs947644106 3511 dbSNP
rs921244990 3512 dbSNP
rs368356132 3513 dbSNP
rs590958 3515 dbSNP
rs1054278420 3528 dbSNP
rs912651547 3532 dbSNP
rs1176301737 3533 dbSNP
rs1247748288 3536 dbSNP
rs1436531409 3538 dbSNP
rs1387960176 3542 dbSNP
rs1157076414 3546 dbSNP
rs1459597025 3553 dbSNP
rs982900414 3559 dbSNP
rs1400801488 3561 dbSNP
rs1369284615 3568 dbSNP
rs950499150 3580 dbSNP
rs1026570153 3582 dbSNP
rs1396745415 3586 dbSNP
rs1293198075 3589 dbSNP
rs973322172 3590 dbSNP
rs1259065239 3593 dbSNP
rs187155471 3595 dbSNP
rs1203312438 3596 dbSNP
rs1249268427 3606 dbSNP
rs1483946970 3610 dbSNP
rs180947844 3617 dbSNP
rs927230151 3621 dbSNP
rs981725744 3637 dbSNP
rs1421817566 3638 dbSNP
rs1249712868 3640 dbSNP
rs577667356 3641 dbSNP
rs189326851 3642 dbSNP
rs1012519078 3654 dbSNP
rs534735662 3655 dbSNP
rs1423995902 3666 dbSNP
rs184822080 3667 dbSNP
rs1168593504 3671 dbSNP
rs1361178307 3673 dbSNP
rs1466596776 3678 dbSNP
rs1312395513 3679 dbSNP
rs555662658 3680 dbSNP
rs1373742200 3681 dbSNP
rs1402347760 3682 dbSNP
rs895520518 3695 dbSNP
rs1361622858 3699 dbSNP
rs1213250680 3700 dbSNP
rs1035367349 3706 dbSNP
rs903336479 3707 dbSNP
rs535357786 3709 dbSNP
rs1211122606 3717 dbSNP
rs1043628432 3723 dbSNP
rs7178060 3725 dbSNP
rs1218614494 3729 dbSNP
rs983102218 3729 dbSNP
rs900061968 3734 dbSNP
rs1184612664 3737 dbSNP
rs951784993 3738 dbSNP
rs1173273934 3741 dbSNP
rs1433945864 3741 dbSNP
rs749318449 3759 dbSNP
rs944013529 3765 dbSNP
rs974208031 3783 dbSNP
rs1299342538 3789 dbSNP
rs1345183535 3790 dbSNP
rs549663811 3792 dbSNP
rs77494460 3801 dbSNP
rs570601536 3807 dbSNP
rs1018450345 3814 dbSNP
rs778212499 3816 dbSNP
rs1320273393 3823 dbSNP
rs150431002 3830 dbSNP
rs141455472 3835 dbSNP
rs138823128 3836 dbSNP
rs1460529348 3840 dbSNP
rs919069564 3841 dbSNP
rs76543082 3843 dbSNP
rs1388598425 3854 dbSNP
rs3177073 3862 dbSNP
rs1391615636 3864 dbSNP
rs1345112433 3878 dbSNP
rs1241758097 3880 dbSNP
rs963266660 3884 dbSNP
rs1446398135 3887 dbSNP
rs752589950 3889 dbSNP
rs1244859002 3897 dbSNP
rs781232625 3901 dbSNP
rs145020884 3907 dbSNP
rs1248191122 3908 dbSNP
rs1468762387 3908 dbSNP
rs1054584906 3919 dbSNP
rs1391743818 3920 dbSNP
rs1251444342 3922 dbSNP
rs1441611526 3930 dbSNP
rs1159383616 3932 dbSNP
rs937411055 3933 dbSNP
rs1399410441 3935 dbSNP
rs905658356 3939 dbSNP
rs1167539235 3942 dbSNP
rs1350760584 3949 dbSNP
rs1440715298 3963 dbSNP
rs991373065 3968 dbSNP
rs1169008611 3969 dbSNP
rs1448311227 3974 dbSNP
rs192825744 3987 dbSNP
rs1349361603 3988 dbSNP
rs959659226 3988 dbSNP
rs1291945060 3989 dbSNP
rs1335234073 3997 dbSNP
rs754764448 3999 dbSNP
rs1200992181 4000 dbSNP
rs1459294082 4005 dbSNP
rs543702694 4006 dbSNP
rs983071020 4009 dbSNP
rs1468667628 4013 dbSNP
rs967517362 4030 dbSNP
rs1419280099 4033 dbSNP
rs1021395511 4036 dbSNP
rs1012154006 4039 dbSNP
rs930348859 4040 dbSNP
rs593544 4041 dbSNP
rs1039947526 4046 dbSNP
rs1334592336 4048 dbSNP
rs1439478581 4051 dbSNP
rs77610970 4054 dbSNP
rs1206333421 4055 dbSNP
rs1356069155 4061 dbSNP
rs1341993717 4075 dbSNP
rs891109336 4079 dbSNP
rs1271000727 4082 dbSNP
rs541104231 4092 dbSNP
rs146649499 4094 dbSNP
rs964504869 4097 dbSNP
rs1319750913 4099 dbSNP
rs1196530802 4100 dbSNP
rs1236130479 4101 dbSNP
rs1272644234 4103 dbSNP
rs1436137941 4106 dbSNP
rs1212394207 4111 dbSNP
rs1258790757 4125 dbSNP
rs1047108623 4126 dbSNP
rs1186452035 4128 dbSNP
rs1426154822 4131 dbSNP
rs1331722948 4137 dbSNP
rs755072707 4150 dbSNP
rs1385252654 4153 dbSNP
rs1018836779 4155 dbSNP
rs1395401653 4156 dbSNP
rs929991408 4157 dbSNP
rs919987305 4161 dbSNP
rs762516157 4163 dbSNP
rs1414024036 4164 dbSNP
rs1038493155 4166 dbSNP
rs1308333234 4177 dbSNP
rs368664667 4189 dbSNP
rs1227958131 4196 dbSNP
rs1428860913 4198 dbSNP
rs1368541718 4203 dbSNP
rs955801645 4209 dbSNP
rs188545354 4215 dbSNP
rs772695091 4216 dbSNP
rs1485393740 4217 dbSNP
rs541089501 4225 dbSNP
rs1010239932 4231 dbSNP
rs1376538558 4231 dbSNP
rs915749225 4242 dbSNP
rs1192983020 4243 dbSNP
rs893103139 4253 dbSNP
rs1033019798 4268 dbSNP
rs1001595994 4277 dbSNP
rs928582741 4288 dbSNP
rs184477680 4289 dbSNP
rs1387103635 4290 dbSNP
rs905970751 4295 dbSNP
rs1382552548 4311 dbSNP
rs1252095877 4313 dbSNP
rs1045960640 4326 dbSNP
rs576307581 4344 dbSNP
rs967107651 4346 dbSNP
rs1324499340 4347 dbSNP
rs1235607207 4350 dbSNP
rs886351600 4352 dbSNP
rs1347223875 4357 dbSNP
rs7227 4366 dbSNP
rs964522226 4368 dbSNP
rs1018474259 4382 dbSNP
rs192029080 4393 dbSNP
rs187870019 4394 dbSNP
rs1260033798 4395 dbSNP
rs1453704020 4396 dbSNP
rs1195102673 4411 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            :|::| ||||||||||||  
Target 5' auGGUGAAACCCCGUCUCUAcu 3'
 		8 - 29
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000341861.5 | 3UTR | GGUCGACAUGGUGAAACCCCGUCUCUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.497 6.7e-3 0.453 1.3e-2 24 Click to see details
GSE28260 Renal cortex and medulla 0.658 7.2e-3 0.654 7.7e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.414 2.5e-2 -0.382 3.6e-2 23 Click to see details
GSE32688 Pancreatic cancer -0.177 1.7e-1 -0.229 1.0e-1 32 Click to see details
GSE38226 Liver fibrosis -0.187 2.1e-1 -0.073 3.8e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.172 2.1e-1 -0.074 3.7e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.051 4.0e-1 -0.080 3.5e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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