pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CASD1   
Synonyms C7orf12, NBLA04196, SOAT
Description CAS1 domain containing 1
Transcript NM_022900   
Expression
Putative miRNA Targets on CASD1
3'UTR of CASD1
(miRNA target sites are highlighted)
>CASD1|NM_022900|3'UTR
   1 GTTCCAAAAATTCTAAAAAACCTAAACTCTTCAGGCTACCTTTGTGTGTCTCTAGAAGAGAAAAGCATCTATCTGGAGAT
  81 ATAAATGTGTATGTAAATATAAACGTTTGTGGCAAGAGGACAGTTCTGTGACATCTGTTGAACATATGTGGTTGTATATA
 161 TTGGAAATGTACATATCCAATATGAAATACTAAAACAAACAAACAAACAAAAAACCAGAATGCATTGTATAGGATTGCAT
 241 GTGAAGTCTTTTCTACTGAATCTATATTTCCATTTGTAAGTGATTTTAAGTTAACATATGAAGGCAGGGAAATGATTACC
 321 TTTCCAGTAAAAAGTATAGATAATTTAATTAACTTAGTGACACCACCAAGTGTTTTGATATAACTAAATTTGTGGTAATA
 401 AGACTGTCTGCACCTGTATTCATTGTGGAACTTCCTCTTTCATTGGAAACTTTCTTACTCAAGAATGACGGCAGTATTGT
 481 TTTCTTATATGTGCAATGAAGTGGAATGATAAACAGTATGCCTTTAATTTATATGTGTTCTTGTTCTGATGTTGTTTCCT
 561 GAAATGATTTTTCTTCCTAACTGTGGTTTTCGGGTATGCAAGCCTAAATCTTTGTACACTTTGTCTCACAGAATAGTTCT
 641 GAGGCTCCATGACAGGGTTTTGTCATTGTTGATGTTATTGTTGCTTCGTTTTATAAAAAAGCCAAAATTTTTTTTCCAAT
 721 CCAAACGTTCACCTGTTTCCTTTCCTCAAGCTATACCAGTGTAATACCAGTTACCCTGTGGATCCATTTAATATGTTATC
 801 CCCACTAATTAATTTTCGTATATTATTTCCAATATTTGGAAAGCTCTTTATAGCCATTTGGTATTTCCTATTACCCACCT
 881 CCTATTTTAAATATTTATCAGTCTAAACTTGTGCAGTGTAGTAAACATGCAAGTTGTTACGATTGAGCTGTATTACCATA
 961 AGTAGAATTTTAAGTAAACTGGTGAATTTGGGCAATAAATGTTTTTGCTTTTTGTTTGATTTTTTTTTACAAGCTAACTG
1041 TTAGAGGTATACATTTATTTATCTGTTGTACAGATTTGATTATGATTTTAATGTTTGAAAGATTGCACTTGTTTGCTTTT
1121 ACTATATGTGGGGTAAAATATATTTTCTGTTCACAGTATATGAAAATATGGAGTAATTTAAACAGTAAATAAACATTCTG
1201 TGGATGCTTATTTTTGTATTGGCAAAGTATCAATTAAACTATATGTGTTCTTTTTCAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaUUCU--CAGAGGGGGACAUAua 5'
            ||||  |||| | |||||||  
Target 5' atAAGACTGTCTGCACCTGTATtc 3'
398 - 421 154.00 -18.10
2
miRNA  3' uaUUCUCAGAGGGGGACAUAUa 5'
            || | | | :  :|||||| 
Target 5' tgAACA-TATGTGGTTGTATAt 3'
139 - 159 127.00 -5.30
3
miRNA  3' uauucucagaggggGACAUAua 5'
                        ||||||  
Target 5' ttgttacgattgagCTGTATta 3'
934 - 955 120.00 -5.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30500986 21 COSMIC
COSN26807827 59 COSMIC
COSN29384662 88 COSMIC
COSN24395884 103 COSMIC
COSN24460877 157 COSMIC
COSN24887280 235 COSMIC
COSN6899501 358 COSMIC
COSN6899502 359 COSMIC
COSN17384722 694 COSMIC
COSN21821361 770 COSMIC
COSN30345229 782 COSMIC
COSN16903655 811 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs568608883 1 dbSNP
rs770042357 2 dbSNP
rs540026140 5 dbSNP
rs1322997072 6 dbSNP
rs1347524516 13 dbSNP
rs1331709281 16 dbSNP
rs1439265508 18 dbSNP
rs746570632 21 dbSNP
rs556826637 25 dbSNP
rs1203617996 29 dbSNP
rs774852126 33 dbSNP
rs1246263230 34 dbSNP
rs1277134404 34 dbSNP
rs759970502 35 dbSNP
rs925218763 36 dbSNP
rs201984099 40 dbSNP
rs990929475 41 dbSNP
rs371171339 47 dbSNP
rs373732621 49 dbSNP
rs1190997142 50 dbSNP
rs1190671710 53 dbSNP
rs1229047045 55 dbSNP
rs949079420 66 dbSNP
rs1363877665 68 dbSNP
rs927490340 70 dbSNP
rs1213927693 72 dbSNP
rs1350138228 78 dbSNP
rs1322387631 83 dbSNP
rs542124480 88 dbSNP
rs61611349 92 dbSNP
rs984545348 93 dbSNP
rs1388453957 105 dbSNP
rs887252651 106 dbSNP
rs1277361656 113 dbSNP
rs1246352497 114 dbSNP
rs1204689690 116 dbSNP
rs1489817821 117 dbSNP
rs907623266 125 dbSNP
rs940186296 127 dbSNP
rs940390390 129 dbSNP
rs1271956320 134 dbSNP
rs1341391944 145 dbSNP
rs193301138 149 dbSNP
rs1295257104 150 dbSNP
rs1220452552 158 dbSNP
rs975757982 159 dbSNP
rs898766611 162 dbSNP
rs148649873 166 dbSNP
rs1254056004 172 dbSNP
rs1050224636 173 dbSNP
rs530242457 174 dbSNP
rs773217408 176 dbSNP
rs536180382 181 dbSNP
rs1050737802 183 dbSNP
rs1178788414 186 dbSNP
rs1433857481 193 dbSNP
rs549868569 193 dbSNP
rs936480600 193 dbSNP
rs540665809 195 dbSNP
rs1021006565 208 dbSNP
rs1205645551 209 dbSNP
rs1482565200 211 dbSNP
rs1249555339 213 dbSNP
rs1212139428 215 dbSNP
rs966503089 216 dbSNP
rs879427593 221 dbSNP
rs1032254830 224 dbSNP
rs1217170540 230 dbSNP
rs762997068 239 dbSNP
rs1010713820 242 dbSNP
rs1288547039 250 dbSNP
rs1429623367 254 dbSNP
rs1024322408 256 dbSNP
rs867861366 257 dbSNP
rs907163916 263 dbSNP
rs563821669 265 dbSNP
rs1394966266 266 dbSNP
rs766147872 267 dbSNP
rs1268198730 272 dbSNP
rs917547123 282 dbSNP
rs1364041123 286 dbSNP
rs1174070072 289 dbSNP
rs1458848937 292 dbSNP
rs970402339 301 dbSNP
rs1412976746 303 dbSNP
rs983171809 308 dbSNP
rs1215068675 310 dbSNP
rs1181652479 319 dbSNP
rs1472173707 330 dbSNP
rs907655881 334 dbSNP
rs751339934 335 dbSNP
rs1183572405 338 dbSNP
rs1483525656 339 dbSNP
rs117114249 341 dbSNP
rs1236784443 341 dbSNP
rs1201265296 342 dbSNP
rs1330524000 343 dbSNP
rs1268385348 347 dbSNP
rs1292159544 349 dbSNP
rs1331981620 364 dbSNP
rs1038983426 370 dbSNP
rs1315548359 378 dbSNP
rs1234752733 381 dbSNP
rs1396923149 386 dbSNP
rs868747570 387 dbSNP
rs961790483 389 dbSNP
rs1437380868 395 dbSNP
rs1446050687 402 dbSNP
rs1389448316 404 dbSNP
rs932863582 406 dbSNP
rs976210005 426 dbSNP
rs922971618 432 dbSNP
rs1361899325 441 dbSNP
rs1166685035 442 dbSNP
rs1424136246 456 dbSNP
rs1255392042 457 dbSNP
rs1050013779 460 dbSNP
rs891096888 470 dbSNP
rs865825824 471 dbSNP
rs925175254 472 dbSNP
rs1207767842 477 dbSNP
rs1187792763 480 dbSNP
rs184276683 487 dbSNP
rs1415806022 494 dbSNP
rs374614673 497 dbSNP
rs1476196799 498 dbSNP
rs1366078955 504 dbSNP
rs563301803 505 dbSNP
rs1319948999 514 dbSNP
rs902644579 515 dbSNP
rs1165737722 518 dbSNP
rs1000695253 525 dbSNP
rs1393190811 532 dbSNP
rs1032555260 533 dbSNP
rs754844206 534 dbSNP
rs529092770 535 dbSNP
rs892275470 553 dbSNP
rs116619843 562 dbSNP
rs1012557105 569 dbSNP
rs1024911871 576 dbSNP
rs970371327 580 dbSNP
rs1458232690 587 dbSNP
rs3763465 592 dbSNP
rs527678540 593 dbSNP
rs142115202 597 dbSNP
rs192182816 599 dbSNP
rs1187422201 621 dbSNP
rs963493701 634 dbSNP
rs767056513 654 dbSNP
rs183811536 658 dbSNP
rs1312129813 659 dbSNP
rs556710049 661 dbSNP
rs932847836 670 dbSNP
rs570110786 677 dbSNP
rs1416152500 682 dbSNP
rs150733636 687 dbSNP
rs752406460 688 dbSNP
rs1349553757 689 dbSNP
rs1225342001 694 dbSNP
rs1221691179 695 dbSNP
rs78711026 702 dbSNP
rs1386421995 703 dbSNP
rs1364785560 705 dbSNP
rs1317851442 706 dbSNP
rs1431358783 707 dbSNP
rs1210801259 708 dbSNP
rs1371091967 709 dbSNP
rs755617690 727 dbSNP
rs1474172159 740 dbSNP
rs1015061613 751 dbSNP
rs572731395 768 dbSNP
rs879092451 773 dbSNP
rs962490018 783 dbSNP
rs1432215634 787 dbSNP
rs762780699 791 dbSNP
rs975860737 794 dbSNP
rs777274357 799 dbSNP
rs36040032 800 dbSNP
rs1483550513 810 dbSNP
rs540601660 818 dbSNP
rs3763464 819 dbSNP
rs1133697 821 dbSNP
rs1232558661 823 dbSNP
rs924915177 833 dbSNP
rs1290374499 846 dbSNP
rs1160473301 850 dbSNP
rs539883276 857 dbSNP
rs988022513 864 dbSNP
rs1328172418 868 dbSNP
rs565825762 871 dbSNP
rs949238365 873 dbSNP
rs1468800080 879 dbSNP
rs1024882339 880 dbSNP
rs1160852286 891 dbSNP
rs1473156525 892 dbSNP
rs1251543894 894 dbSNP
rs1180339816 906 dbSNP
rs563398280 909 dbSNP
rs928699517 917 dbSNP
rs1199946954 920 dbSNP
rs1313005575 926 dbSNP
rs1004544419 927 dbSNP
rs769119007 931 dbSNP
rs1270311530 933 dbSNP
rs1014565049 934 dbSNP
rs1439605493 940 dbSNP
rs1133698 941 dbSNP
rs1278711653 942 dbSNP
rs1373594835 943 dbSNP
rs973538699 944 dbSNP
rs1028770401 953 dbSNP
rs1334665219 953 dbSNP
rs1451300558 954 dbSNP
rs1278597167 959 dbSNP
rs143978662 961 dbSNP
rs1161011482 975 dbSNP
rs1457416557 979 dbSNP
rs1350749592 980 dbSNP
rs954335704 989 dbSNP
rs15671 995 dbSNP
rs1133700 999 dbSNP
rs1006438190 1020 dbSNP
rs1187443168 1020 dbSNP
rs565284977 1020 dbSNP
rs1249938848 1031 dbSNP
rs529044711 1034 dbSNP
rs1209647579 1035 dbSNP
rs944257967 1036 dbSNP
rs1036536318 1037 dbSNP
rs551724609 1038 dbSNP
rs1358135176 1043 dbSNP
rs1284769269 1045 dbSNP
rs998079066 1048 dbSNP
rs978315181 1066 dbSNP
rs1030103008 1069 dbSNP
rs1321948551 1073 dbSNP
rs1435139848 1077 dbSNP
rs923912225 1085 dbSNP
rs1436085240 1092 dbSNP
rs1315717596 1102 dbSNP
rs1407494352 1106 dbSNP
rs953265078 1109 dbSNP
rs189869925 1116 dbSNP
rs1163549579 1124 dbSNP
rs1443298597 1125 dbSNP
rs1007286553 1126 dbSNP
rs1189335151 1132 dbSNP
rs1184267620 1135 dbSNP
rs1240596956 1146 dbSNP
rs1224036957 1154 dbSNP
rs773447177 1161 dbSNP
rs1032018856 1162 dbSNP
rs574263307 1165 dbSNP
rs541600699 1170 dbSNP
rs1357223623 1173 dbSNP
rs1414624013 1174 dbSNP
rs1299643514 1180 dbSNP
rs1228513646 1186 dbSNP
rs1192816276 1187 dbSNP
rs1393012263 1196 dbSNP
rs1268118270 1204 dbSNP
rs1438124177 1211 dbSNP
rs1332084826 1213 dbSNP
rs947868216 1217 dbSNP
rs1436526306 1226 dbSNP
rs1173046664 1232 dbSNP
rs1046297200 1234 dbSNP
rs1409519916 1240 dbSNP
rs906372661 1241 dbSNP
rs774397268 1242 dbSNP
rs1004765275 1245 dbSNP
rs1478467266 1246 dbSNP
rs1014868308 1248 dbSNP
rs898812238 1251 dbSNP
rs994534947 1259 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000297273.4 | 3UTR | UAUAUGUCUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000297273.4 | 3UTR | UAUAUGUCUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000297273.4 | 3UTR | AUAUGUCUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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