pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CAMK2N1   
Synonyms PRO1489
Description calcium/calmodulin dependent protein kinase II inhibitor 1
Transcript NM_018584   
Expression
Putative miRNA Targets on CAMK2N1
3'UTR of CAMK2N1
(miRNA target sites are highlighted)
>CAMK2N1|NM_018584|3'UTR
   1 CTCCCCCAAAGACAATGAGTTAAGGGAGAGAATAAGAACGGCGGTAACAGTTATTGGCAAAAAGCATGAAAAGAGAAAGC
  81 ACTTTGAAATTTATTACTAGCTTGCTACCCACGATGAAATCAACAACCTGTATCTGGTATCAGGCCGGGAGACAGATGAG
 161 GCGAGAGGAGGAGGAGGAGGAGGAGAAGGCTCTGGGCTCCTCTGCAAAAATAAAAATAAAAAAATAAATAAAATTTTAAA
 241 AATAATAAAAATTCACTATATACACATATAAAGAAATAAAAAGAAGTCTCAGTTGCAGCTATTTGTCAAAATTAATATCC
 321 ATTTCTTTTTATATACGGTGAATATTGCGCAATTATAGATCTGGATTTTGAACCACTTAATGAAGCGGCAACACCAGGTG
 401 TTTTGAGGTGTTGGCATTCTTCGCTGATTTGGCTGTTCCCAATGTTTACATTATTTAATCTTGCAAAAATGGTTCTGTGC
 481 ACTTGGATGTGAAATGCTGTCCAGTTTTATTTTTTTTATGTTGTTATCCTTGGATGTACAAAAAATTCAGAAAATGATCT
 561 CTGTAGATATTCTGTTTTATTTTGGTCATCTTTAGAAGTTATCAGGAATGTGTTTAAAACAAGAAGAGAACTTTTCTAAG
 641 GAATGATACATAGAAAAGATTTTATTTTAAAATGAGTTGTAAAGCTTGTGTTTCTTTGTTGCTGCAAGCTATCTGCCCAA
 721 GTTAATGCAAATGGACACATTTTTTATGTCAGAAAAACACACACACACACACACACACACACACACACACACGAAAAACA
 801 AAGAAAAAAATGCTTGAGCTTTTTCTAACTTCCCCTTGCAGTCTGTTGTGTGAGCAGCCTGTTTATTTCTCTAATATTAT
 881 GTCAGTTTATTCTCTTTAATGGACTGTAAAAAAATGTAATCACAAGAGTGCCAAATATCTTGAAATGCCAAAAGGCATTT
 961 TAGTTTCTTTTCTCTGTGCTCTGAGTCCACGTACAGGAATGCTTGGAGTGTCTTTTCTGTTATTTATAGGGATTCTCTTA
1041 AGGCACACCAGCTGCCTGTTTTGCATGGTATTTGCAAAAATGCCTCTTGCGTGAGGAAATCTTTTACCATTTTTTGTTTG
1121 CAACTTTGGACCTCAAGAGGTTTCCCTTCCCTTCCCCGTTCCCTCTTTTCTTAATTCAATATTCTGTATGTTGCACCTTG
1201 AACCAGCACACAGGGCTATTTCTCCAATGTACAATAAAAGAATTGTTCCTGTGTCTCAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gugaaugaagaaacGUCUACUc 5'
                        ||||||| 
Target 5' atcaggccgggagaCAGATGAg 3'
139 - 160 140.00 -12.40
2
miRNA  3' guGAAUGAA-GAAACGU-CUACUc 5'
            || :||| ||   || ||||| 
Target 5' taCTAGCTTGCTACCCACGATGAa 3'
95 - 118 124.00 -8.70
3
miRNA  3' gugaaugaAGAAACGUCUAcuc 5'
                  ||| ||:||||   
Target 5' gaaaatgaTCTCTGTAGATatt 3'
550 - 571 106.00 -7.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30514000 30 COSMIC
COSN7983907 30 COSMIC
COSN30457298 43 COSMIC
COSN26969087 46 COSMIC
COSN30109927 55 COSMIC
COSN31513831 61 COSMIC
COSN30177599 63 COSMIC
COSN31570357 68 COSMIC
COSN31568262 88 COSMIC
COSN5364238 95 COSMIC
COSN26576139 97 COSMIC
COSN26509318 138 COSMIC
COSN2529642 165 COSMIC
COSN30100425 169 COSMIC
COSN26573753 173 COSMIC
COSN31490109 217 COSMIC
COSN31489141 561 COSMIC
COSN7199805 570 COSMIC
COSN31607828 628 COSMIC
COSN32063017 663 COSMIC
COSN26229055 692 COSMIC
COSN27258542 756 COSMIC
COSN27464077 756 COSMIC
COSN20094470 757 COSMIC
COSN20090170 758 COSMIC
COSN22625283 816 COSMIC
COSN31544458 901 COSMIC
COSN31546767 951 COSMIC
COSN5798123 991 COSMIC
COSN31483107 1090 COSMIC
COSN31569878 1096 COSMIC
COSN9057686 1132 COSMIC
COSN31562204 1177 COSMIC
COSN31608715 1240 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs778043761 3 dbSNP
rs1211995972 8 dbSNP
rs1032453270 9 dbSNP
rs199959572 15 dbSNP
rs777324226 17 dbSNP
rs1244472016 22 dbSNP
rs996580208 26 dbSNP
rs1356505910 32 dbSNP
rs964153871 38 dbSNP
rs1280161794 39 dbSNP
rs1238439630 41 dbSNP
rs748605767 42 dbSNP
rs773597386 44 dbSNP
rs200497795 46 dbSNP
rs1325857489 50 dbSNP
rs1231476460 52 dbSNP
rs1343602363 57 dbSNP
rs1397886736 60 dbSNP
rs917952787 65 dbSNP
rs1403134430 76 dbSNP
rs1017733291 79 dbSNP
rs1464773806 84 dbSNP
rs1425486500 95 dbSNP
rs1171204737 99 dbSNP
rs550642805 99 dbSNP
rs1477414742 107 dbSNP
rs1260953431 111 dbSNP
rs1009079542 112 dbSNP
rs890663720 118 dbSNP
rs1274915257 121 dbSNP
rs1442526718 126 dbSNP
rs11539081 130 dbSNP
rs1254920100 142 dbSNP
rs1198358748 146 dbSNP
rs1438614555 147 dbSNP
rs1260324194 149 dbSNP
rs1219652103 155 dbSNP
rs772507380 163 dbSNP
rs1276901016 166 dbSNP
rs547186569 186 dbSNP
rs547323430 186 dbSNP
rs778508058 186 dbSNP
rs979647006 190 dbSNP
rs532495482 210 dbSNP
rs968212032 217 dbSNP
rs1464926505 218 dbSNP
rs1048008252 221 dbSNP
rs993775605 224 dbSNP
rs1473119090 225 dbSNP
rs899133828 229 dbSNP
rs1038123666 234 dbSNP
rs938068906 237 dbSNP
rs1439135230 238 dbSNP
rs953236070 238 dbSNP
rs1170646692 246 dbSNP
rs1432955382 249 dbSNP
rs1199623917 253 dbSNP
rs1030056998 256 dbSNP
rs1256618063 263 dbSNP
rs1212135265 264 dbSNP
rs533853334 267 dbSNP
rs926705857 272 dbSNP
rs1283601339 273 dbSNP
rs1046508882 277 dbSNP
rs1379330052 279 dbSNP
rs1479311601 280 dbSNP
rs745495565 281 dbSNP
rs1362539813 283 dbSNP
rs1446373891 287 dbSNP
rs140536427 301 dbSNP
rs919424526 309 dbSNP
rs1483562110 318 dbSNP
rs186800743 320 dbSNP
rs1405816422 330 dbSNP
rs1389943308 331 dbSNP
rs1160900895 334 dbSNP
rs1006091397 335 dbSNP
rs528485704 343 dbSNP
rs1208357550 346 dbSNP
rs561579876 348 dbSNP
rs1044863229 349 dbSNP
rs1224240363 352 dbSNP
rs1012357534 353 dbSNP
rs896582818 356 dbSNP
rs1208094059 359 dbSNP
rs1056523310 361 dbSNP
rs1220433321 364 dbSNP
rs1286893060 373 dbSNP
rs1348483991 386 dbSNP
rs543364993 388 dbSNP
rs988005182 391 dbSNP
rs1276337235 395 dbSNP
rs1436961216 411 dbSNP
rs923928141 422 dbSNP
rs1228785995 428 dbSNP
rs1421496992 441 dbSNP
rs1044043730 442 dbSNP
rs780718240 443 dbSNP
rs924950287 448 dbSNP
rs1426841116 450 dbSNP
rs1446175601 458 dbSNP
rs1358768770 459 dbSNP
rs911423550 464 dbSNP
rs768155176 494 dbSNP
rs1489589338 495 dbSNP
rs575872489 496 dbSNP
rs1263914504 502 dbSNP
rs563900858 503 dbSNP
rs545122459 509 dbSNP
rs1410437939 510 dbSNP
rs1019776871 517 dbSNP
rs1344011758 518 dbSNP
rs1473198885 518 dbSNP
rs1401757881 522 dbSNP
rs975816626 527 dbSNP
rs1414741079 550 dbSNP
rs1296975269 559 dbSNP
rs1397610587 561 dbSNP
rs962053467 564 dbSNP
rs1176293245 565 dbSNP
rs1186222606 569 dbSNP
rs1424884609 571 dbSNP
rs1174735544 573 dbSNP
rs1008022308 574 dbSNP
rs1479056070 576 dbSNP
rs954843599 578 dbSNP
rs1014535281 594 dbSNP
rs1192992030 599 dbSNP
rs182259303 601 dbSNP
rs577710318 625 dbSNP
rs1472291494 627 dbSNP
rs1237646817 628 dbSNP
rs1211075563 636 dbSNP
rs1211657889 644 dbSNP
rs1442131622 658 dbSNP
rs552803011 658 dbSNP
rs1318446154 669 dbSNP
rs567737444 669 dbSNP
rs951944476 675 dbSNP
rs534564936 681 dbSNP
rs1023485294 683 dbSNP
rs993725127 697 dbSNP
rs1012507893 703 dbSNP
rs1209340529 711 dbSNP
rs112049009 721 dbSNP
rs748734657 728 dbSNP
rs1037672380 733 dbSNP
rs1378742255 734 dbSNP
rs573579975 738 dbSNP
rs1467540909 745 dbSNP
rs1170568099 746 dbSNP
rs766892818 746 dbSNP
rs1284958431 752 dbSNP
rs1450299075 754 dbSNP
rs1451372961 756 dbSNP
rs7520427 756 dbSNP
rs71010558 757 dbSNP
rs1472556644 758 dbSNP
rs1491282227 758 dbSNP
rs753588194 758 dbSNP
rs1227266555 760 dbSNP
rs1386624054 760 dbSNP
rs1310961348 762 dbSNP
rs999615731 762 dbSNP
rs905230536 764 dbSNP
rs1391447683 766 dbSNP
rs1331178347 770 dbSNP
rs760010123 788 dbSNP
rs1460861166 789 dbSNP
rs1165507136 790 dbSNP
rs1352132426 790 dbSNP
rs1175272631 793 dbSNP
rs1180718361 793 dbSNP
rs1220796283 793 dbSNP
rs1237335802 793 dbSNP
rs1265994424 793 dbSNP
rs1287616422 793 dbSNP
rs1354519371 793 dbSNP
rs1423349616 793 dbSNP
rs143510553 793 dbSNP
rs1440610575 793 dbSNP
rs1489395042 793 dbSNP
rs201950578 793 dbSNP
rs75317375 793 dbSNP
rs1163148920 799 dbSNP
rs687922 800 dbSNP
rs1043734542 803 dbSNP
rs902552630 803 dbSNP
rs1405095735 805 dbSNP
rs1267858301 806 dbSNP
rs1190539690 807 dbSNP
rs1264631855 811 dbSNP
rs1489859190 811 dbSNP
rs1046899015 820 dbSNP
rs1216727648 825 dbSNP
rs11539080 828 dbSNP
rs1258614358 833 dbSNP
rs890053831 834 dbSNP
rs913708626 835 dbSNP
rs1052238729 840 dbSNP
rs936553674 844 dbSNP
rs925200584 854 dbSNP
rs1302480259 865 dbSNP
rs1404871687 886 dbSNP
rs975391727 896 dbSNP
rs1246949272 897 dbSNP
rs529575172 899 dbSNP
rs1466236993 901 dbSNP
rs1157024643 915 dbSNP
rs922790342 915 dbSNP
rs1271138994 917 dbSNP
rs745688155 921 dbSNP
rs1377987517 934 dbSNP
rs1175101143 939 dbSNP
rs111271138 950 dbSNP
rs1425723485 952 dbSNP
rs1193701671 954 dbSNP
rs1290872383 968 dbSNP
rs951126667 970 dbSNP
rs1230316388 973 dbSNP
rs1487656433 975 dbSNP
rs907569738 976 dbSNP
rs1201803104 983 dbSNP
rs1297029194 990 dbSNP
rs1256887034 1003 dbSNP
rs1435846499 1007 dbSNP
rs1223294793 1011 dbSNP
rs756952196 1012 dbSNP
rs1321984313 1014 dbSNP
rs751547431 1018 dbSNP
rs1368014759 1019 dbSNP
rs984440564 1023 dbSNP
rs951687455 1026 dbSNP
rs1023516297 1027 dbSNP
rs1397940836 1031 dbSNP
rs990712723 1032 dbSNP
rs777796479 1046 dbSNP
rs1468062390 1047 dbSNP
rs1034854677 1050 dbSNP
rs1171270601 1082 dbSNP
rs1475078134 1083 dbSNP
rs28410966 1085 dbSNP
rs972232221 1087 dbSNP
rs569489076 1090 dbSNP
rs1167343189 1091 dbSNP
rs1189025634 1097 dbSNP
rs1423973309 1102 dbSNP
rs1427464786 1107 dbSNP
rs538125963 1109 dbSNP
rs551205533 1115 dbSNP
rs1201430436 1120 dbSNP
rs1460241615 1121 dbSNP
rs1168696831 1124 dbSNP
rs758213283 1130 dbSNP
rs1265186294 1137 dbSNP
rs1339309853 1139 dbSNP
rs1268430667 1141 dbSNP
rs902584027 1144 dbSNP
rs1016925181 1155 dbSNP
rs755167658 1157 dbSNP
rs563628303 1158 dbSNP
rs1378822458 1161 dbSNP
rs889749954 1162 dbSNP
rs550396464 1185 dbSNP
rs1340337039 1187 dbSNP
rs1013600676 1190 dbSNP
rs1050468488 1198 dbSNP
rs892554099 1201 dbSNP
rs1052186565 1209 dbSNP
rs376661075 1218 dbSNP
rs1299268300 1220 dbSNP
rs1386772664 1222 dbSNP
rs1368876415 1227 dbSNP
rs1295704171 1228 dbSNP
rs1441232905 1251 dbSNP
rs1240339034 1257 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gugaaugaagaaacgUCUACUc 5'
                         ||| || 
Target 5' ----------aggcgAGAGGAg 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000375078.3 | 3UTR | AGGCGAGAGGAGGAGGAGGAGGAGGAGAAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.665 2.0e-4 -0.636 4.2e-4 24 Click to see details
GSE28260 Renal cortex and medulla -0.454 6.0e-2 -0.511 3.7e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.303 7.5e-2 0.237 1.3e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.206 1.6e-1 0.167 2.1e-1 25 Click to see details
GSE38226 Liver fibrosis 0.224 1.6e-1 0.214 1.8e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.144 2.2e-1 0.100 2.9e-1 32 Click to see details
GSE27834 Pluripotent stem cells 0.148 2.9e-1 0.350 9.2e-2 16 Click to see details
GSE17306 Multiple myeloma 0.078 3.0e-1 0.493 1.6e-4 49 Click to see details
GSE17498 Multiple myeloma 0.062 3.5e-1 0.086 3.0e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells -0.063 3.9e-1 -0.120 2.9e-1 23 Click to see details
GSE19350 CNS germ cell tumors 0.064 4.2e-1 0.448 7.2e-2 12 Click to see details
GSE14794 Lymphoblastoid cells -0.02 4.3e-1 -0.057 3.0e-1 90 Click to see details
GSE21687 Ependynoma primary tumors -0.022 4.3e-1 0.004 4.9e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.024 4.6e-1 0.316 8.7e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.024 4.6e-1 0.316 8.7e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.024 4.6e-1 0.316 8.7e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.024 4.6e-1 0.316 8.7e-2 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.33 0 -0.356 0 79 Click to see details
LUSC -0.293 0.04 -0.311 0.03 38 Click to see details
THCA 0.22 0.05 0.181 0.09 59 Click to see details
CHOL -0.59 0.05 -0.467 0.1 9 Click to see details
LIHC 0.237 0.05 0.249 0.04 49 Click to see details
CESC 0.972 0.08 1.000 0.5 3 Click to see details
PRAD 0.201 0.09 0.161 0.14 48 Click to see details
ESCA -0.472 0.1 -0.467 0.1 9 Click to see details
KICH -0.195 0.18 -0.181 0.2 24 Click to see details
LUAD -0.247 0.23 -0.355 0.14 11 Click to see details
BLCA 0.19 0.23 0.221 0.2 17 Click to see details
HNSC -0.105 0.25 -0.074 0.32 42 Click to see details
STAD 0.127 0.26 0.148 0.22 29 Click to see details
UCEC -0.156 0.26 -0.249 0.15 19 Click to see details
KIRC 0.064 0.31 0.063 0.31 65 Click to see details
KIRP 0.079 0.34 0.102 0.29 31 Click to see details
PAAD 0.252 0.37 0.800 0.1 4 Click to see details
PAAD 0.252 0.37 0.800 0.1 4 Click to see details
PAAD 0.252 0.37 0.800 0.1 4 Click to see details
PAAD 0.252 0.37 0.800 0.1 4 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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