miRTarBase - #MIRT624448


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pre-miRNA Information
pre-miRNA hsa-mir-3152   
Genomic Coordinates chr9: 18573306 - 18573379
Description Homo sapiens miR-3152 stem-loop
Comment Berezikov et al. proposed this sequence as a miRNA candidate based on the RAKE method .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3152-5p
Sequence 11| AUUGCCUCUGUUCUAACACAAG |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1019691326 2 dbSNP
rs1282676806 8 dbSNP
rs762305650 11 dbSNP
rs1364318615 12 dbSNP
rs556364307 18 dbSNP
rs1002755159 19 dbSNP
rs1238555909 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CALCOCO2   
Synonyms NDP52
Description calcium binding and coiled-coil domain 2
Transcript NM_005831   
Expression
Putative miRNA Targets on CALCOCO2
3'UTR of CALCOCO2
(miRNA target sites are highlighted)		 
>CALCOCO2|NM_005831|3'UTR
   1 GTATCCCAACCTCTTGGATGTATACAGAGATTTTATAGAATAGAACCTATAGCTTCTACCATGAGTTATATGAGTCAAGA
  81 TCCTGCCTAACCTGAAATTATTAGGGATTTACTCAGCCCTGCTGCCGCTAACAGTGGAGTTATGTCACTGATCTGAAGGT
 161 CACTGTTAAGGGCTTCTGCTGCCATCCTTGTGGGTTGCTACCTTTAAGTCGCATAACTCTAGCTGTATCATCCTCTCACC
 241 TGTCATTCTTCTGAGGGTCTCAGTACAAGGGCCCTGGGATGGAGCCAACCTGGGTATTCACAACAGGCCTGACTTGATAC
 321 TAAGTGATTAGTTTTCCAAGTTGTCCCACTGCCATTCAAAGTCAGCCCTTGAGTGTATTTGTTCTCAGTCCTAACCCTGG
 401 GGCCAGAGATTGGTCCGAGGTTGAGAATTCCTTCCTCCTCATCCTTGGTGTTGCTTTCTCCAAATGATTGTTTTAGACTA
 481 GCCAAAAATGCCGTGGCAAAGAGCTCAGAAATCCAATTTGGATACCAAAGGTTTCTCATGTTAATTTCTCAGCCCCCAAA
 561 GAAGCATCTTACTCCTGAACCTTAGACAGGAAGTATTGTTTCAGTCACAGAAAGCTTTTCTGGGTACCTCTGGTTAGCAC
 641 TTTCTACTCTCTGATATTTCCTATGTACATAGCTTTTATTGTTGTAAATCCTTTCTTAATGGTTAAATAGGATTGTTAGC
 721 AACTATGGGTTTGCAGTTTTCTGAGTAGGTGAGTTTTGAATATGGGTAAATCAGAATAATGAGACAACTTGTTAATCTCT
 801 TTAATACTAAAAATAAATTACTCTTCTATTTCAGGGACTTAGGTAATTTAAAATAAACCTTCAATTTATGGTCTTCTGTT
 881 TTGAAGCTCATGGGAAAATTGTGATCAAAAGGGCTATGGGAAGGGCAGACCCCGCCAATGATTTCTCTTCACCTGTCTTA
 961 AGATTAAATAAAAAAGAGTGTCCTGGCAGTTATCTTGAGGTGGGGAAGGAGGTGATGAAACATTAGTTTGTGAAATCCAA
1041 GGCCCTGGCTTGCTTTCTTTCTTTTTTTTTTTTTTTTTTTGAAACAGTCTCTCTCTGTCACCCAGGCTGGCGTGCAATGG
1121 CGCAGTTGACTCACTACAGCCTCTGCCTCCCAGGTTCAAGCGATTCTCATGCCTTAGCCTCCCAAGTAGCTGGGATTACA
1201 GGTGTGTGCCGCAATGCCCAGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCGA
1281 ACTCCTGGCCTCACGTGATCTGTCCACTTCAGCCGTCCAAAGTGCTGGGATTACAAGCGTGAGCCACTGTGCTGGGCCCG
1361 AGGCCCTGACTTCTTGCTGTAACTTTCCATGCATTTTTTTTAAAAGGAGCAGTGTGGATTTTCGCACCCTTTGTGAACTA
1441 AGTTCAATGCGCTCTATCCAAATTTGCCTAATTGAACTATAAGAAAGTAATAATTCCATTTTCTATCCCCTCAGGGACTG
1521 AACAAATGGAAATAACTCCCAGGCAGTATCAGGTGGTCACTACAGAGACTTCCACAAAAACTTTTGAATGATGTGAAACA
1601 CGATGTCATGAATAAGGGTTGAGCCAACTATAGCTCTGTGTTCCTACTGGGCTTTCCCTAATGTGGTTGGGAGTTATGCC
1681 CTAGACTAACTGTATTGTCCTAGTCACAGCTCCTTGCTTTGATTTCATCCTTGATAAAATGAAGATGAAACTTACACTAC
1761 TTCTCCAAGCCTTTTGCTGTCTTAAGAATAAGACCTGAGATTAACACTAACCCTAGAATAGAAATGTAATAGGGAGATGG
1841 TAATAAAGGAGTTTTTCTGGCACATACCCTCCCTACAGAATTTCTGTTGCTCCCCAGATCCAGTGAAGAATTGCAGTTTC
1921 ATTTATTTTGTACCAGTCAGCTCTTAATTAAGTACATGAATGGAGAGGAACAGTGGTGCACATAATCCAAATCAGTGAAT
2001 ACCATTTTCTGGTGAATTACCCACCCCTTTGCCCCTGCTACCCCGAGGGTTACCATGATTGTCAACAGCAGCAGGAGCCC
2081 TTCCACAGGGCTTGGTAAAAAAACCAGTTGAGGTGTTAATGACCCTTTTTGCTGGGTGTAAAACAAAGCATCTTTAACCA
2161 CTGTTCATTATCCCCAGCTGCTCTTACCAAGGCTTTGAAGGGGGAAATTATGCTCTAGGCAGCCACTAGTAGTAAACAAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaACACAAUCUUGUCUCCGuua 5'
            |||| |:|: | |||||   
Target 5' acTGTGCTGGGCCCGAGGCcct 3'
 1346 - 1367 128.00 -13.62
2 
miRNA  3' gaacacaAUCUUGUCUCCGUUa 5'
                 |:|:|::||| ||| 
Target 5' agggcccTGGGATGGAGCCAAc 3'
 268 - 289 127.00 -8.80
3 
miRNA  3' gaacacAAUCUUGU--CUCCGUUa 5'
                | ||||:|  ||| ||| 
Target 5' ggtaaaTCAGAATAATGAGACAAc 3'
 765 - 788 126.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26969031 2 COSMIC
COSN26969030 39 COSMIC
COSN507377 82 COSMIC
COSN1720837 155 COSMIC
COSN30141176 186 COSMIC
COSN20618412 818 COSMIC
COSN22426304 998 COSMIC
COSN20093308 1058 COSMIC
COSN20093310 1062 COSMIC
COSN5840532 1331 COSMIC
COSN30668363 1337 COSMIC
COSN30637877 1340 COSMIC
COSN20072265 1402 COSMIC
COSN30724145 1402 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748873558 7 dbSNP
rs370021564 10 dbSNP
rs1324252241 11 dbSNP
rs773686834 12 dbSNP
rs1434565902 18 dbSNP
rs747585518 21 dbSNP
rs1379174229 26 dbSNP
rs760246354 26 dbSNP
rs368965437 29 dbSNP
rs955495651 35 dbSNP
rs777106523 37 dbSNP
rs770204009 39 dbSNP
rs987088562 40 dbSNP
rs367617158 42 dbSNP
rs763207480 44 dbSNP
rs369461455 47 dbSNP
rs3744605 50 dbSNP
rs763598403 52 dbSNP
rs767334646 54 dbSNP
rs750286398 57 dbSNP
rs755908643 60 dbSNP
rs779768956 61 dbSNP
rs974477900 62 dbSNP
rs767552503 66 dbSNP
rs920035622 71 dbSNP
rs753513090 75 dbSNP
rs754548944 79 dbSNP
rs551249541 93 dbSNP
rs142936561 103 dbSNP
rs1010179578 105 dbSNP
rs749298977 114 dbSNP
rs758380990 116 dbSNP
rs1287153684 119 dbSNP
rs1360959305 127 dbSNP
rs1055106950 128 dbSNP
rs968555196 133 dbSNP
rs917770579 140 dbSNP
rs1318993687 156 dbSNP
rs1246174183 159 dbSNP
rs1321733522 165 dbSNP
rs1294618619 166 dbSNP
rs949200318 183 dbSNP
rs1286990826 185 dbSNP
rs551604431 190 dbSNP
rs985265634 203 dbSNP
rs1388481559 208 dbSNP
rs1361195476 211 dbSNP
rs902418916 212 dbSNP
rs1000574443 213 dbSNP
rs1420065727 231 dbSNP
rs1053430476 233 dbSNP
rs111623438 234 dbSNP
rs1343462995 239 dbSNP
rs995939527 240 dbSNP
rs182181766 258 dbSNP
rs1264248625 259 dbSNP
rs1195779496 262 dbSNP
rs1450169777 262 dbSNP
rs534791657 263 dbSNP
rs965452566 264 dbSNP
rs1210905395 266 dbSNP
rs1222491760 269 dbSNP
rs535828910 274 dbSNP
rs1278977679 276 dbSNP
rs977212382 282 dbSNP
rs918623827 289 dbSNP
rs555768599 292 dbSNP
rs1216307524 295 dbSNP
rs1316907712 298 dbSNP
rs1278516664 331 dbSNP
rs1229161267 338 dbSNP
rs1213040927 341 dbSNP
rs1329091095 345 dbSNP
rs1260607344 352 dbSNP
rs1030061427 359 dbSNP
rs929948115 364 dbSNP
rs1396662520 368 dbSNP
rs1329385168 375 dbSNP
rs1488916566 376 dbSNP
rs1424437046 381 dbSNP
rs984425059 402 dbSNP
rs1477173857 403 dbSNP
rs1267168621 404 dbSNP
rs1200068343 405 dbSNP
rs1470201137 416 dbSNP
rs1480350677 417 dbSNP
rs955574687 418 dbSNP
rs1008804038 420 dbSNP
rs186046835 422 dbSNP
rs961913100 432 dbSNP
rs367938946 436 dbSNP
rs1342491748 437 dbSNP
rs1274006921 440 dbSNP
rs974131954 446 dbSNP
rs1398959333 448 dbSNP
rs566366066 455 dbSNP
rs558844842 456 dbSNP
rs1373096226 459 dbSNP
rs990869225 479 dbSNP
rs1045276826 490 dbSNP
rs1445975524 493 dbSNP
rs572604711 494 dbSNP
rs1331009439 499 dbSNP
rs917963788 509 dbSNP
rs1300007542 517 dbSNP
rs1412948031 526 dbSNP
rs190271998 550 dbSNP
rs113174988 558 dbSNP
rs1057267468 560 dbSNP
rs771280775 565 dbSNP
rs891501415 573 dbSNP
rs1010308197 578 dbSNP
rs1440883372 584 dbSNP
rs1232923767 588 dbSNP
rs182496718 596 dbSNP
rs1440324114 598 dbSNP
rs866070146 604 dbSNP
rs1404123270 608 dbSNP
rs978325845 614 dbSNP
rs777093345 616 dbSNP
rs185391645 629 dbSNP
rs904449965 635 dbSNP
rs1239284537 643 dbSNP
rs1006736989 644 dbSNP
rs1305640376 645 dbSNP
rs1281326936 647 dbSNP
rs1353843017 651 dbSNP
rs1018076271 661 dbSNP
rs191171829 662 dbSNP
rs1053673325 664 dbSNP
rs900187023 665 dbSNP
rs1358968995 670 dbSNP
rs965169481 679 dbSNP
rs867685277 705 dbSNP
rs1420821117 707 dbSNP
rs931598024 712 dbSNP
rs1178428531 736 dbSNP
rs568460420 742 dbSNP
rs1248635158 750 dbSNP
rs182495082 754 dbSNP
rs1051546117 755 dbSNP
rs1468822327 761 dbSNP
rs1176889381 764 dbSNP
rs1380962798 775 dbSNP
rs34091460 783 dbSNP
rs1441697119 784 dbSNP
rs1160370468 789 dbSNP
rs1215687347 800 dbSNP
rs146106997 802 dbSNP
rs1286339063 804 dbSNP
rs1226540017 819 dbSNP
rs1355659085 822 dbSNP
rs545289073 824 dbSNP
rs535850856 833 dbSNP
rs1338780917 836 dbSNP
rs984531127 838 dbSNP
rs1401064149 859 dbSNP
rs1347325434 875 dbSNP
rs11434 879 dbSNP
rs775828489 883 dbSNP
rs948299811 890 dbSNP
rs995735404 891 dbSNP
rs1165058117 892 dbSNP
rs1475968723 904 dbSNP
rs1027156481 905 dbSNP
rs959371254 906 dbSNP
rs1323991707 914 dbSNP
rs376569257 917 dbSNP
rs1192657704 921 dbSNP
rs1351454497 926 dbSNP
rs1486032977 927 dbSNP
rs1253253681 931 dbSNP
rs189256497 934 dbSNP
rs1025095373 935 dbSNP
rs547222720 939 dbSNP
rs939513637 950 dbSNP
rs977978482 954 dbSNP
rs923784650 958 dbSNP
rs560628021 965 dbSNP
rs1297315944 971 dbSNP
rs1364467291 979 dbSNP
rs1376972832 988 dbSNP
rs936494394 989 dbSNP
rs891545835 994 dbSNP
rs140074280 1005 dbSNP
rs1395910100 1008 dbSNP
rs149773748 1016 dbSNP
rs1325977719 1022 dbSNP
rs1462621190 1025 dbSNP
rs921838268 1026 dbSNP
rs1359397999 1027 dbSNP
rs1421337841 1029 dbSNP
rs1189303910 1030 dbSNP
rs931675041 1040 dbSNP
rs1253622066 1041 dbSNP
rs1215493892 1048 dbSNP
rs1229203110 1048 dbSNP
rs1051409559 1049 dbSNP
rs6504584 1053 dbSNP
rs199578721 1054 dbSNP
rs538918273 1057 dbSNP
rs1219064515 1058 dbSNP
rs1372355467 1058 dbSNP
rs1204088488 1059 dbSNP
rs1445230560 1060 dbSNP
rs1177907454 1062 dbSNP
rs1209683222 1062 dbSNP
rs1237612233 1062 dbSNP
rs1254552619 1062 dbSNP
rs1437786622 1062 dbSNP
rs1457619489 1062 dbSNP
rs35356632 1062 dbSNP
rs982274977 1062 dbSNP
rs1239081945 1064 dbSNP
rs549706411 1065 dbSNP
rs1181856192 1066 dbSNP
rs1238560134 1066 dbSNP
rs552833066 1067 dbSNP
rs904168201 1067 dbSNP
rs1383249199 1068 dbSNP
rs1006790991 1070 dbSNP
rs1300657003 1071 dbSNP
rs1433740996 1074 dbSNP
rs1375798228 1080 dbSNP
rs1175330274 1081 dbSNP
rs1035857596 1082 dbSNP
rs1415687006 1084 dbSNP
rs1408054578 1086 dbSNP
rs1159913857 1088 dbSNP
rs1363210781 1088 dbSNP
rs1169441639 1097 dbSNP
rs566286206 1107 dbSNP
rs940447270 1112 dbSNP
rs1448303378 1113 dbSNP
rs1260011010 1122 dbSNP
rs193089215 1123 dbSNP
rs1353616324 1129 dbSNP
rs1339420233 1134 dbSNP
rs1241826885 1141 dbSNP
rs1449359393 1147 dbSNP
rs901051607 1150 dbSNP
rs1286535024 1152 dbSNP
rs1309998275 1153 dbSNP
rs1413758764 1154 dbSNP
rs763580909 1162 dbSNP
rs182916966 1163 dbSNP
rs1397981249 1165 dbSNP
rs1027230170 1175 dbSNP
rs765456779 1177 dbSNP
rs187215929 1181 dbSNP
rs1025384077 1187 dbSNP
rs537548143 1191 dbSNP
rs568407470 1194 dbSNP
rs750187158 1203 dbSNP
rs1164353561 1205 dbSNP
rs1443139327 1207 dbSNP
rs1420380174 1208 dbSNP
rs1191784653 1211 dbSNP
rs7216848 1212 dbSNP
rs1262896628 1217 dbSNP
rs1207371245 1219 dbSNP
rs545917016 1224 dbSNP
rs1239144284 1225 dbSNP
rs1474264121 1232 dbSNP
rs1263146160 1234 dbSNP
rs969362224 1235 dbSNP
rs1335065141 1236 dbSNP
rs766240452 1254 dbSNP
rs1294671322 1260 dbSNP
rs1031046089 1266 dbSNP
rs1196234126 1268 dbSNP
rs957866098 1270 dbSNP
rs1318760277 1273 dbSNP
rs1383817019 1279 dbSNP
rs755277942 1280 dbSNP
rs1325286524 1285 dbSNP
rs921869219 1288 dbSNP
rs953262002 1295 dbSNP
rs565170456 1296 dbSNP
rs191776532 1315 dbSNP
rs7217035 1316 dbSNP
rs1195845987 1320 dbSNP
rs940328471 1321 dbSNP
rs1036527078 1329 dbSNP
rs752831561 1330 dbSNP
rs1399729398 1339 dbSNP
rs931522603 1340 dbSNP
rs1279207140 1348 dbSNP
rs1048528619 1351 dbSNP
rs1221906884 1352 dbSNP
rs1196320150 1360 dbSNP
rs144652100 1361 dbSNP
rs560764610 1367 dbSNP
rs1345736574 1371 dbSNP
rs1046621437 1382 dbSNP
rs1329141045 1387 dbSNP
rs777929610 1390 dbSNP
rs1039311600 1392 dbSNP
rs1202250882 1394 dbSNP
rs901088948 1394 dbSNP
rs998089731 1402 dbSNP
rs1397558539 1403 dbSNP
rs1170007468 1410 dbSNP
rs1445235321 1412 dbSNP
rs1464795608 1413 dbSNP
rs529701801 1414 dbSNP
rs999499432 1417 dbSNP
rs1047352344 1418 dbSNP
rs1031543083 1424 dbSNP
rs886935503 1425 dbSNP
rs1192919533 1427 dbSNP
rs1436849026 1430 dbSNP
rs573028323 1431 dbSNP
rs1197197558 1440 dbSNP
rs1345411241 1445 dbSNP
rs1006076181 1446 dbSNP
rs1234894914 1448 dbSNP
rs7222365 1451 dbSNP
rs183862864 1452 dbSNP
rs1441657638 1462 dbSNP
rs1336436575 1477 dbSNP
rs189500022 1478 dbSNP
rs558100219 1487 dbSNP
rs1173840309 1488 dbSNP
rs781540416 1491 dbSNP
rs746140367 1514 dbSNP
rs770049226 1515 dbSNP
rs868407855 1518 dbSNP
rs988379601 1524 dbSNP
rs914084139 1527 dbSNP
rs573141012 1530 dbSNP
rs117327540 1537 dbSNP
rs555637449 1543 dbSNP
rs962046862 1546 dbSNP
rs1484509561 1550 dbSNP
rs1256517376 1553 dbSNP
rs1211408082 1558 dbSNP
rs1403505055 1563 dbSNP
rs925696569 1571 dbSNP
rs867434227 1578 dbSNP
rs1281987126 1579 dbSNP
rs117542323 1596 dbSNP
rs769157072 1602 dbSNP
rs568670928 1603 dbSNP
rs773812343 1610 dbSNP
rs1281378391 1613 dbSNP
rs1331930182 1619 dbSNP
rs1355115373 1632 dbSNP
rs1313855536 1638 dbSNP
rs1417081531 1639 dbSNP
rs920371029 1642 dbSNP
rs942415301 1644 dbSNP
rs1039363963 1662 dbSNP
rs1277833112 1668 dbSNP
rs1401827295 1672 dbSNP
rs930384482 1681 dbSNP
rs1055442550 1685 dbSNP
rs761336543 1686 dbSNP
rs1353128853 1695 dbSNP
rs916767644 1704 dbSNP
rs574038848 1709 dbSNP
rs948185492 1714 dbSNP
rs1159843607 1718 dbSNP
rs1408032365 1718 dbSNP
rs1474012451 1729 dbSNP
rs527246147 1730 dbSNP
rs922264230 1733 dbSNP
rs1486494449 1744 dbSNP
rs1489117836 1748 dbSNP
rs1240169078 1753 dbSNP
rs544362445 1754 dbSNP
rs1447556279 1767 dbSNP
rs1286407552 1769 dbSNP
rs1211965974 1771 dbSNP
rs1334438681 1776 dbSNP
rs748873609 1780 dbSNP
rs1046958762 1782 dbSNP
rs1235394856 1783 dbSNP
rs768370706 1784 dbSNP
rs1266182078 1800 dbSNP
rs116941442 1808 dbSNP
rs1052433759 1820 dbSNP
rs1361552530 1825 dbSNP
rs1038177180 1831 dbSNP
rs905279021 1847 dbSNP
rs1438602162 1850 dbSNP
rs1165141547 1851 dbSNP
rs893782362 1857 dbSNP
rs1476003704 1863 dbSNP
rs1011012540 1865 dbSNP
rs1417093948 1866 dbSNP
rs73989228 1870 dbSNP
rs1035441801 1872 dbSNP
rs953197502 1874 dbSNP
rs766078085 1885 dbSNP
rs1019316414 1887 dbSNP
rs896470816 1895 dbSNP
rs1306031260 1898 dbSNP
rs1272722584 1900 dbSNP
rs1215590065 1901 dbSNP
rs1364525924 1906 dbSNP
rs1301800042 1909 dbSNP
rs1440845808 1913 dbSNP
rs961972395 1914 dbSNP
rs1021203937 1915 dbSNP
rs753667536 1928 dbSNP
rs1169483669 1937 dbSNP
rs1391967402 1939 dbSNP
rs1191626432 1944 dbSNP
rs1421407690 1944 dbSNP
rs1388712247 1948 dbSNP
rs759503547 1949 dbSNP
rs979574094 1957 dbSNP
rs1327182471 1981 dbSNP
rs1253678982 1986 dbSNP
rs1027292143 1987 dbSNP
rs1195638132 1988 dbSNP
rs1017705327 1989 dbSNP
rs1232447605 1990 dbSNP
rs1205501935 1998 dbSNP
rs1240987577 2010 dbSNP
rs765286246 2021 dbSNP
rs1309577753 2027 dbSNP
rs1278681704 2043 dbSNP
rs539798015 2045 dbSNP
rs975120129 2046 dbSNP
rs922286841 2047 dbSNP
rs553113613 2048 dbSNP
rs991202870 2054 dbSNP
rs1297187705 2055 dbSNP
rs915628027 2063 dbSNP
rs1372144851 2066 dbSNP
rs948255031 2067 dbSNP
rs1434011487 2074 dbSNP
rs1356866082 2076 dbSNP
rs933672012 2084 dbSNP
rs1417333366 2097 dbSNP
rs983140414 2097 dbSNP
rs982284569 2098 dbSNP
rs1249934782 2099 dbSNP
rs908465829 2105 dbSNP
rs1255826977 2123 dbSNP
rs928234189 2125 dbSNP
rs35377200 2126 dbSNP
rs547296820 2126 dbSNP
rs1456880973 2136 dbSNP
rs1038227549 2149 dbSNP
rs904995553 2151 dbSNP
rs935608887 2154 dbSNP
rs1056533044 2173 dbSNP
rs1223970187 2175 dbSNP
rs752729899 2177 dbSNP
rs571975876 2203 dbSNP
rs540936522 2207 dbSNP
rs1310839303 2208 dbSNP
rs1413865806 2214 dbSNP
rs1375847421 2218 dbSNP
rs893813339 2223 dbSNP
rs946664089 2240 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000258947.3 | 3UTR | UACAGGGGAGGCUGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000258947.3 | 3UTR | UACAGGGGAGGCUGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000258947.3 | 3UTR | UACAGGGGAGGCUGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000258947.3 | 3UTR | UACAGGGGAGGCUGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
75 hsa-miR-3152-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092535 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT461731 NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 2 2
MIRT468456 SET SET nuclear proto-oncogene 2 2
MIRT482192 AHR aryl hydrocarbon receptor 2 2
MIRT507923 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT512208 C18orf25 chromosome 18 open reading frame 25 2 6
MIRT526238 STARD4 StAR related lipid transfer domain containing 4 2 2
MIRT536131 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536280 LIMA1 LIM domain and actin binding 1 2 2
MIRT544251 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT548054 GOLGA7 golgin A7 2 2
MIRT563443 ISCA1 iron-sulfur cluster assembly 1 2 2
MIRT565643 SIX4 SIX homeobox 4 2 2
MIRT614870 PDE12 phosphodiesterase 12 2 2
MIRT614923 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT615793 FAM124A family with sequence similarity 124 member A 2 2
MIRT618557 VLDLR very low density lipoprotein receptor 2 2
MIRT622147 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT622390 RSBN1 round spermatid basic protein 1 2 2
MIRT624185 DDX19B DEAD-box helicase 19B 2 2
MIRT624448 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT625340 TAPBP TAP binding protein 2 2
MIRT625370 IRGQ immunity related GTPase Q 2 2
MIRT627276 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT627746 RAD54L2 RAD54 like 2 2 2
MIRT629578 RFC2 replication factor C subunit 2 2 4
MIRT630537 LGALS8 galectin 8 2 4
MIRT630559 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT630568 SOWAHA sosondowah ankyrin repeat domain family member A 2 4
MIRT630763 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT635424 LRP10 LDL receptor related protein 10 2 2
MIRT636011 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT636337 PHAX phosphorylated adaptor for RNA export 2 2
MIRT638413 POU3F2 POU class 3 homeobox 2 2 2
MIRT639358 INIP INTS3 and NABP interacting protein 2 2
MIRT642124 DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A 2 4
MIRT642828 KIAA0319 KIAA0319 2 2
MIRT644017 NUCB1 nucleobindin 1 2 2
MIRT644038 WWC2 WW and C2 domain containing 2 2 2
MIRT644153 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644649 SNX9 sorting nexin 9 2 2
MIRT645798 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT647633 FAIM2 Fas apoptotic inhibitory molecule 2 2 2
MIRT648528 KIAA1143 KIAA1143 2 2
MIRT648851 PDLIM3 PDZ and LIM domain 3 2 2
MIRT648880 TUBGCP5 tubulin gamma complex associated protein 5 2 2
MIRT650777 TNFRSF10A TNF receptor superfamily member 10a 2 2
MIRT654200 RNF19B ring finger protein 19B 2 2
MIRT654508 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT655249 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT656089 MTA3 metastasis associated 1 family member 3 2 2
MIRT656599 LRRC55 leucine rich repeat containing 55 2 2
MIRT659194 CYBB cytochrome b-245 beta chain 2 2
MIRT660000 C1orf115 chromosome 1 open reading frame 115 2 4
MIRT661715 KLF8 Kruppel like factor 8 2 2
MIRT661813 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT668360 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT679734 CABP4 calcium binding protein 4 2 2
MIRT708616 NUDT18 nudix hydrolase 18 2 2
MIRT709034 TROVE2 TROVE domain family member 2 2 2
MIRT709573 DMGDH dimethylglycine dehydrogenase 2 2
MIRT709665 AJAP1 adherens junctions associated protein 1 2 2
MIRT709874 TRAF1 TNF receptor associated factor 1 2 2
MIRT710821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT710883 PARL presenilin associated rhomboid like 2 2
MIRT711547 LCAT lecithin-cholesterol acyltransferase 2 2
MIRT712017 STX1B syntaxin 1B 2 2
MIRT713058 BLVRA biliverdin reductase A 2 2
MIRT713129 THRB thyroid hormone receptor beta 2 2
MIRT713878 MOB3A MOB kinase activator 3A 2 2
MIRT714154 NXPH3 neurexophilin 3 2 2
MIRT719755 FLYWCH1 FLYWCH-type zinc finger 1 2 2
MIRT720213 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT722728 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT725652 ABI2 abl interactor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-3152-5p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)

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