miRTarBase - #MIRT624880


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pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-5p
Sequence 21| AGCUUCCAUGACUCCUGAUGGA |42
Evidence Experimental
Experiments 454
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372327506 9 dbSNP
rs1259362191 10 dbSNP
rs1215292065 12 dbSNP
rs1197671843 16 dbSNP
rs1468768022 20 dbSNP
rs1273755407 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AASDHPPT   
Synonyms AASD-PPT, ACPS, CGI-80, LYS2, LYS5
Description aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Transcript NM_015423   
Expression
Putative miRNA Targets on AASDHPPT
3'UTR of AASDHPPT
(miRNA target sites are highlighted)		 
>AASDHPPT|NM_015423|3'UTR
   1 TGATTCCCTGAGTAACAAAGGGAAATGAAAACTGTTTGTGATCTTCCGTATTCACTGAAAAATAAATGCTTGTTTAGTAT
  81 CAAATTTTATTTCACGAAAGTTTTTTTAAAGAACAGAAACTTTTCCAATTAAAAAAAAAAAGCAGACTTCTGGTTCAAGA
 161 TAGCTCACTGGAATACATGTTTACCTCTTTCTTTCCTAAATTGCATTGAATTGATAGGAAGGATGGCGGAATCTTAAAGT
 241 GATACATGCTAACTGTAGAAAAAAATAGAAAATGCACATAAGCAAAAGGAAACATTTAAATGCTATCTTTCAAAGATAAC
 321 TACTCTTAAAACCTTGAGTATCTTTTCAGACCTTTTTCTTGGCAAATGAATCCATATTGACATATTTGATTTTTTTAAAA
 401 ACATGGAAACGTACTGTTTTGTAAATTCTTTTTAACTGCACATCTACTGTTCATAAATATACCTCTGTAACATAACTTTT
 481 TGTGGTTCTAATGTACTCTGTTGTATAGCTAATACAAGTTAGGATGCTTTTGGCCAGAGGTAACAGTGTCCAAATATAAT
 561 TGGCCTAAGTAACCTAGGAAATTGTTTGACATAACACAGGGTTCAGGGGTGTCATTAAAGACACACTTTTTTTGCCTTGA
 641 CCTCAGTTGGTTTGTTTTGCCTTAGGCTATTCCACCTCTCGATCACAAGAGCTGCTGCTATAACTTCCAGTTTTACATCT
 721 TTGTAAAATTGTATCTCAAAGGCAGAAAAGGCCATTTCGTCTCTCATTTGTTTTATCCATGAGGAAGATTTTTAACAAAA
 801 GCCTCCAGAAGATTTCCCCTCAGTTTCCATTGACTTAGATCAGGTTACAGAGAAAGGCAATGTCTGACATTTTTGGTCTC
 881 TGTTAGAAGTAGACTCTGTTGAAAAGAAAGAAGCTAAGCTAGGTGTGAAGAATGGAATTGGAAGCCCACTGCCTTCCCAT
 961 AAGAAAGGTTTACCATAATTTACTCACTTTTTTCTGTGTTAGACATTTTGATTATCTGCAGTTTATTACTACAAGCAGTG
1041 GCAGAGTGAATGTCCTTGTACATTTTGAGTTACATGCTTAATTATGTCCTTGAGAAAGTTTCTAAAAGTGGAATGATTGG
1121 TTTGACTGGTTCATAGGGCTTTAATTATACAATTTACCCCTCTAATTAGTACTATATGTATGTGACTTCCCTCCCCCTGC
1201 CAGAATACTCCTTGGTCAATTGTAGGTATTCTTTTTGGTTTAATTTTTGCCAATGTAATTAAAAAATGGTATGTCATTTT
1281 TAAAATTTGTATTTCTTTCATTACAAATAAGATTGTTATGTCAGTATTGTTATTGGCTTTTCGTATTCCTCTTAACGTGA
1361 ACCGTCTGTTCATTGTTTTTACCTGTTTTCGTTTTAGCAAGTAGTACTTAATTTAAAGTGTGAACTTAATATATAAGATG
1441 CCAGGACCATCATATTGATGACAAAAATCTATTATGTGGTTGTAGTGCATGTCTTGGAGTTAAACTCTTAAGTATCAAGA
1521 AGTAAAATAATTTCATTGTTTCTGTTACTAACATTAAAAGTGTGCAAATTGTATAAAATTAGGTACTTCGATTAGTAAAA
1601 GAAAAAAATTTGAATGTTTTTTTTTTTTATTTTATTAAGCATGCCCAGTTATGCCAAGCATAGTAAATAAAGGTCAAGTA
1681 GCATTTATAATAGAGGAAGTATTGTTATCCCTAGCATGAGTGTAATGGTGATATGAAAAACTTTGTCTTGTCATTATAAT
1761 AATAAAAAAATGAACATTTATTATGAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agguaguCCUCAGUACCUUCGa 5'
                 ||| |  ||||||| 
Target 5' gaagaatGGAAT--TGGAAGCc 3'
 927 - 946 147.00 -10.80
2 
miRNA  3' agguaguccucaGUACCUUCGa 5'
                      ||||||| | 
Target 5' tttttttaaaaaCATGGAAACg 3'
 390 - 411 118.00 -8.60
3 
miRNA  3' agguAGUCC--UC-AGU-ACCUUcga 5'
              ||| |  || ||| |||||   
Target 5' tggtTCAAGATAGCTCACTGGAAtac 3'
 151 - 176 116.00 -5.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30473754 54 COSMIC
COSN13298053 97 COSMIC
COSN30121939 100 COSMIC
COSN27309083 142 COSMIC
COSN30061369 159 COSMIC
COSN5295728 389 COSMIC
COSN20627237 568 COSMIC
COSN31778896 703 COSMIC
COSN8212860 741 COSMIC
COSN5256280 809 COSMIC
COSN16245767 1404 COSMIC
COSN22501508 1443 COSMIC
COSN9029946 1490 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772876329 1 dbSNP
rs766169452 10 dbSNP
rs368570555 11 dbSNP
rs754898031 12 dbSNP
rs1281479912 13 dbSNP
rs200693517 14 dbSNP
rs1430682833 15 dbSNP
rs1178844058 17 dbSNP
rs186476157 21 dbSNP
rs756129079 24 dbSNP
rs543573488 25 dbSNP
rs749483980 26 dbSNP
rs753886943 33 dbSNP
rs370423833 35 dbSNP
rs923258302 40 dbSNP
rs779310937 41 dbSNP
rs757295165 42 dbSNP
rs746432274 43 dbSNP
rs369569371 44 dbSNP
rs776069965 48 dbSNP
rs374891598 49 dbSNP
rs1326171940 51 dbSNP
rs1482553761 52 dbSNP
rs1272030874 55 dbSNP
rs1406736644 67 dbSNP
rs909811744 80 dbSNP
rs888048132 89 dbSNP
rs961212666 94 dbSNP
rs573652164 96 dbSNP
rs1036517251 97 dbSNP
rs1410490416 98 dbSNP
rs773915396 99 dbSNP
rs919342156 100 dbSNP
rs898017293 101 dbSNP
rs1403367802 103 dbSNP
rs938806217 109 dbSNP
rs1013748381 111 dbSNP
rs1057148585 115 dbSNP
rs544243871 116 dbSNP
rs1182348187 119 dbSNP
rs1471977778 126 dbSNP
rs1248903974 127 dbSNP
rs1940755 128 dbSNP
rs915879990 129 dbSNP
rs1485767324 131 dbSNP
rs368580660 131 dbSNP
rs948737043 131 dbSNP
rs562724196 132 dbSNP
rs904818696 142 dbSNP
rs533250072 165 dbSNP
rs72977072 168 dbSNP
rs999017419 172 dbSNP
rs957938545 180 dbSNP
rs1224973813 186 dbSNP
rs113901481 197 dbSNP
rs900916904 198 dbSNP
rs1160563492 206 dbSNP
rs1387861008 206 dbSNP
rs1211398136 210 dbSNP
rs1490278484 214 dbSNP
rs1472946409 217 dbSNP
rs181132335 228 dbSNP
rs866061106 229 dbSNP
rs1448512072 233 dbSNP
rs1248335033 241 dbSNP
rs185327669 243 dbSNP
rs773121274 244 dbSNP
rs1193180433 247 dbSNP
rs1235179292 248 dbSNP
rs567435411 256 dbSNP
rs923381072 267 dbSNP
rs1283815771 274 dbSNP
rs1445982321 279 dbSNP
rs931950553 283 dbSNP
rs147946690 284 dbSNP
rs1364597531 293 dbSNP
rs1016842745 295 dbSNP
rs1290415225 296 dbSNP
rs1435057161 301 dbSNP
rs909240748 306 dbSNP
rs189738400 315 dbSNP
rs1036654591 316 dbSNP
rs1293404944 326 dbSNP
rs533679053 327 dbSNP
rs1161095424 328 dbSNP
rs1248307275 342 dbSNP
rs551363423 352 dbSNP
rs1187652424 358 dbSNP
rs1463519469 358 dbSNP
rs1046548540 369 dbSNP
rs1254789041 370 dbSNP
rs183456565 371 dbSNP
rs1452261230 375 dbSNP
rs1274711131 377 dbSNP
rs960579794 382 dbSNP
rs1359017357 390 dbSNP
rs1228100880 397 dbSNP
rs539310369 397 dbSNP
rs1363721966 398 dbSNP
rs1031951797 404 dbSNP
rs1437721314 405 dbSNP
rs916015693 411 dbSNP
rs775187307 412 dbSNP
rs1370755014 414 dbSNP
rs554205961 417 dbSNP
rs1009433022 429 dbSNP
rs868621769 437 dbSNP
rs978763446 440 dbSNP
rs576712227 441 dbSNP
rs1396592509 442 dbSNP
rs1462229332 444 dbSNP
rs1477629419 445 dbSNP
rs1246235661 447 dbSNP
rs1219428093 448 dbSNP
rs1020836417 449 dbSNP
rs1183682655 457 dbSNP
rs1484189477 472 dbSNP
rs141764480 473 dbSNP
rs545706895 477 dbSNP
rs1053374571 489 dbSNP
rs762473708 490 dbSNP
rs1160907962 492 dbSNP
rs901301559 506 dbSNP
rs1367469111 507 dbSNP
rs976629826 514 dbSNP
rs1452836929 515 dbSNP
rs1287002891 519 dbSNP
rs145522053 522 dbSNP
rs1307033266 530 dbSNP
rs1377069460 534 dbSNP
rs1176471020 536 dbSNP
rs147804891 542 dbSNP
rs953472807 552 dbSNP
rs986238064 553 dbSNP
rs909209454 558 dbSNP
rs1473613032 560 dbSNP
rs1252543271 561 dbSNP
rs963405872 562 dbSNP
rs1181742810 563 dbSNP
rs1482167092 566 dbSNP
rs11226919 578 dbSNP
rs796295245 590 dbSNP
rs1258164134 591 dbSNP
rs1337480425 591 dbSNP
rs1211223888 592 dbSNP
rs1312170811 594 dbSNP
rs1277103092 595 dbSNP
rs1382214959 597 dbSNP
rs1450708654 609 dbSNP
rs889563504 621 dbSNP
rs1317865783 626 dbSNP
rs1238821542 627 dbSNP
rs1259427856 628 dbSNP
rs1407647048 629 dbSNP
rs1380849200 631 dbSNP
rs1303265854 637 dbSNP
rs1326285794 641 dbSNP
rs972271643 642 dbSNP
rs1357427837 645 dbSNP
rs1005208729 646 dbSNP
rs73537649 654 dbSNP
rs1457646384 660 dbSNP
rs148845850 661 dbSNP
rs1046546156 666 dbSNP
rs1258503429 670 dbSNP
rs1034959289 677 dbSNP
rs926810354 681 dbSNP
rs937762117 682 dbSNP
rs1053503843 687 dbSNP
rs1266985617 691 dbSNP
rs1156689731 696 dbSNP
rs1226020711 701 dbSNP
rs1022994275 702 dbSNP
rs751295883 703 dbSNP
rs1312985273 705 dbSNP
rs970148102 707 dbSNP
rs1231049250 708 dbSNP
rs552720387 720 dbSNP
rs1470252775 739 dbSNP
rs1175694442 740 dbSNP
rs978727558 741 dbSNP
rs1445964295 745 dbSNP
rs1320029889 751 dbSNP
rs761653022 756 dbSNP
rs577598024 759 dbSNP
rs1165754144 760 dbSNP
rs1391113787 764 dbSNP
rs545266531 780 dbSNP
rs1423415916 782 dbSNP
rs1190873359 789 dbSNP
rs1412119925 789 dbSNP
rs901101428 791 dbSNP
rs998537236 795 dbSNP
rs1206358529 796 dbSNP
rs1489179909 807 dbSNP
rs1265453778 818 dbSNP
rs989438890 823 dbSNP
rs1028138991 824 dbSNP
rs922896157 824 dbSNP
rs954053376 829 dbSNP
rs1286841210 834 dbSNP
rs1228839380 841 dbSNP
rs1364444959 842 dbSNP
rs1295305027 849 dbSNP
rs934128973 855 dbSNP
rs1392998440 858 dbSNP
rs1294150312 863 dbSNP
rs143466600 870 dbSNP
rs779905903 885 dbSNP
rs1170941291 889 dbSNP
rs1049949727 891 dbSNP
rs527446093 892 dbSNP
rs1389869539 894 dbSNP
rs889537501 894 dbSNP
rs1267475473 897 dbSNP
rs190756578 897 dbSNP
rs1007639985 903 dbSNP
rs1016364340 910 dbSNP
rs1190086838 920 dbSNP
rs548774582 923 dbSNP
rs1276317909 924 dbSNP
rs1038133164 931 dbSNP
rs972073533 936 dbSNP
rs1251474658 938 dbSNP
rs993868756 946 dbSNP
rs919281033 949 dbSNP
rs1175190990 951 dbSNP
rs1270762995 952 dbSNP
rs1331579951 958 dbSNP
rs750365556 968 dbSNP
rs1302129582 985 dbSNP
rs982813198 986 dbSNP
rs1035332279 988 dbSNP
rs1480670063 988 dbSNP
rs1198563281 991 dbSNP
rs1427153956 995 dbSNP
rs1412785723 1001 dbSNP
rs1430583893 1005 dbSNP
rs896438768 1012 dbSNP
rs1166474270 1015 dbSNP
rs566498170 1020 dbSNP
rs1012029887 1027 dbSNP
rs561001456 1030 dbSNP
rs938191013 1032 dbSNP
rs527363004 1034 dbSNP
rs1197614841 1040 dbSNP
rs1023462254 1062 dbSNP
rs549903043 1068 dbSNP
rs758462785 1073 dbSNP
rs1253260094 1075 dbSNP
rs183675852 1084 dbSNP
rs1000652680 1087 dbSNP
rs1042040851 1089 dbSNP
rs1249400564 1091 dbSNP
rs1306456724 1093 dbSNP
rs756193564 1100 dbSNP
rs1345706614 1114 dbSNP
rs998110957 1116 dbSNP
rs1230895020 1117 dbSNP
rs1321528405 1124 dbSNP
rs1290241117 1125 dbSNP
rs988851067 1129 dbSNP
rs1366136832 1133 dbSNP
rs922831685 1134 dbSNP
rs372530226 1138 dbSNP
rs1295670891 1144 dbSNP
rs955641700 1145 dbSNP
rs571600195 1158 dbSNP
rs889589614 1162 dbSNP
rs1413557604 1166 dbSNP
rs911359640 1175 dbSNP
rs941523891 1179 dbSNP
rs188134950 1181 dbSNP
rs1293545856 1185 dbSNP
rs1189442128 1193 dbSNP
rs918368475 1195 dbSNP
rs1016329373 1209 dbSNP
rs1255153052 1211 dbSNP
rs1198687406 1212 dbSNP
rs899236239 1216 dbSNP
rs994013063 1218 dbSNP
rs1266603115 1225 dbSNP
rs192927390 1226 dbSNP
rs566261083 1230 dbSNP
rs1187093875 1231 dbSNP
rs1247178175 1235 dbSNP
rs777752617 1242 dbSNP
rs184552615 1251 dbSNP
rs1333864296 1252 dbSNP
rs73537650 1254 dbSNP
rs982353209 1257 dbSNP
rs1320711726 1259 dbSNP
rs1405084450 1268 dbSNP
rs1456244937 1268 dbSNP
rs556033259 1269 dbSNP
rs1000722954 1276 dbSNP
rs1367714840 1277 dbSNP
rs1181489210 1283 dbSNP
rs1451304157 1285 dbSNP
rs1033492685 1288 dbSNP
rs1209511121 1290 dbSNP
rs537921147 1296 dbSNP
rs959506408 1299 dbSNP
rs956177440 1305 dbSNP
rs1282168396 1307 dbSNP
rs1211881018 1315 dbSNP
rs989618861 1316 dbSNP
rs1357268173 1318 dbSNP
rs1284024695 1319 dbSNP
rs80195741 1321 dbSNP
rs1029630096 1322 dbSNP
rs1302932314 1326 dbSNP
rs1342950817 1333 dbSNP
rs1348575573 1334 dbSNP
rs867893861 1343 dbSNP
rs577537432 1344 dbSNP
rs1360623642 1347 dbSNP
rs1225589758 1357 dbSNP
rs73537654 1358 dbSNP
rs978283667 1361 dbSNP
rs922284057 1364 dbSNP
rs933658327 1365 dbSNP
rs796381605 1391 dbSNP
rs757621650 1392 dbSNP
rs1452466943 1395 dbSNP
rs1291315698 1396 dbSNP
rs1216370191 1403 dbSNP
rs1241475561 1408 dbSNP
rs889722215 1411 dbSNP
rs1344778367 1422 dbSNP
rs941288432 1426 dbSNP
rs541472313 1431 dbSNP
rs929783148 1432 dbSNP
rs1038192275 1434 dbSNP
rs917546685 1450 dbSNP
rs1436550692 1456 dbSNP
rs150930147 1459 dbSNP
rs1300905714 1465 dbSNP
rs7554 1468 dbSNP
rs1370960283 1479 dbSNP
rs1167684700 1483 dbSNP
rs1026826891 1489 dbSNP
rs1427166057 1513 dbSNP
rs1174459561 1525 dbSNP
rs1478400800 1534 dbSNP
rs1268200416 1536 dbSNP
rs1160420390 1539 dbSNP
rs906497709 1545 dbSNP
rs1197568057 1551 dbSNP
rs1044935754 1554 dbSNP
rs1345141199 1566 dbSNP
rs574923807 1567 dbSNP
rs140657313 1574 dbSNP
rs1306324459 1582 dbSNP
rs1281338972 1587 dbSNP
rs1003973516 1590 dbSNP
rs1280751895 1591 dbSNP
rs1411311644 1592 dbSNP
rs1307246228 1602 dbSNP
rs1350694039 1602 dbSNP
rs1439748836 1603 dbSNP
rs1360617689 1610 dbSNP
rs1033862854 1611 dbSNP
rs1413792524 1615 dbSNP
rs1428722911 1615 dbSNP
rs1174332459 1616 dbSNP
rs891872342 1616 dbSNP
rs1239516518 1617 dbSNP
rs1479864030 1617 dbSNP
rs370229857 1617 dbSNP
rs58915339 1617 dbSNP
rs878949853 1617 dbSNP
rs959600737 1623 dbSNP
rs989712198 1624 dbSNP
rs1048683 1625 dbSNP
rs1229673794 1625 dbSNP
rs966883492 1629 dbSNP
rs1224148349 1630 dbSNP
rs1221661556 1632 dbSNP
rs1283395633 1635 dbSNP
rs1326997790 1641 dbSNP
rs1381103342 1642 dbSNP
rs1029765899 1652 dbSNP
rs1245035763 1660 dbSNP
rs1451879636 1660 dbSNP
rs1334868934 1666 dbSNP
rs891109142 1672 dbSNP
rs1389378459 1673 dbSNP
rs1461870631 1686 dbSNP
rs1158670136 1688 dbSNP
rs1328617032 1691 dbSNP
rs118065945 1697 dbSNP
rs1182772410 1698 dbSNP
rs922345759 1701 dbSNP
rs933647465 1707 dbSNP
rs1241830752 1709 dbSNP
rs963028763 1711 dbSNP
rs1464969278 1713 dbSNP
rs144891342 1715 dbSNP
rs1178153437 1718 dbSNP
rs1407811279 1722 dbSNP
rs1323116302 1727 dbSNP
rs1313229200 1730 dbSNP
rs1025769631 1742 dbSNP
rs1456099648 1743 dbSNP
rs951637344 1745 dbSNP
rs1406133350 1751 dbSNP
rs1468860692 1753 dbSNP
rs910914297 1755 dbSNP
rs1331732484 1762 dbSNP
rs991840135 1764 dbSNP
rs138744064 1771 dbSNP
rs1451946577 1771 dbSNP
rs1351811983 1776 dbSNP
rs941256007 1777 dbSNP
rs917682489 1784 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000278618.4 | 3UTR | GAAUGGAAUUGGAAGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000278618.4 | 3UTR | AAUGGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000278618.4 | 3UTR | GAAUGGAAUUGGAAGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000278618.4 | 3UTR | GAAUGGAAUUGGAAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000278618.4 | 3UTR | GUGUGAAGAAUGGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000278618.4 | 3UTR | AAUGGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.464 0.12 0.262 0.27 8 Click to see details
BRCA 0.23 0.24 0.301 0.17 12 Click to see details
BLCA 0.728 0.24 1.000 0.5 3 Click to see details
HNSC -0.353 0.25 -0.200 0.35 6 Click to see details
HNSC -0.353 0.25 -0.200 0.35 6 Click to see details
HNSC -0.353 0.25 -0.200 0.35 6 Click to see details
HNSC -0.353 0.25 -0.200 0.35 6 Click to see details
84 hsa-miR-2115-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT155281 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT257301 MYLIP myosin regulatory light chain interacting protein 2 8
MIRT441907 SEPN1 selenoprotein N 2 2
MIRT442300 ZNF496 zinc finger protein 496 2 2
MIRT468235 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT469331 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT470203 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT475945 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT481449 ARRB2 arrestin beta 2 2 2
MIRT497440 SLC16A10 solute carrier family 16 member 10 2 2
MIRT498270 KIAA1644 KIAA1644 2 2
MIRT499225 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501742 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501762 NRF1 nuclear respiratory factor 1 2 6
MIRT527902 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT528559 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT531252 PDF peptide deformylase, mitochondrial 2 2
MIRT539490 ACTN4 actinin alpha 4 2 2
MIRT550683 YARS tyrosyl-tRNA synthetase 2 2
MIRT573441 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT616740 DCTN5 dynactin subunit 5 2 2
MIRT617626 RAB3IP RAB3A interacting protein 2 2
MIRT620780 MT1A metallothionein 1A 2 2
MIRT623174 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624880 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT625799 MDC1 mediator of DNA damage checkpoint 1 2 2
MIRT629790 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT630535 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT630762 ZNF445 zinc finger protein 445 2 2
MIRT630921 UNC93A unc-93 homolog A 2 2
MIRT630949 PANK1 pantothenate kinase 1 2 2
MIRT631688 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT633898 FGF10 fibroblast growth factor 10 2 2
MIRT635935 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636177 THBD thrombomodulin 2 2
MIRT636730 AFAP1 actin filament associated protein 1 2 2
MIRT638038 SHPK sedoheptulokinase 2 2
MIRT639164 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT639260 MANEAL mannosidase endo-alpha like 2 2
MIRT639327 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT639849 YY1 YY1 transcription factor 2 2
MIRT641474 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642783 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643653 MYOCD myocardin 2 2
MIRT645717 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT648018 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT648563 MEMO1 mediator of cell motility 1 2 2
MIRT648731 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT650179 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT650721 TNFSF8 TNF superfamily member 8 2 2
MIRT652179 TRIM44 tripartite motif containing 44 2 2
MIRT654272 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT654493 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT654861 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT656392 MCU mitochondrial calcium uniporter 2 2
MIRT656623 LRRC15 leucine rich repeat containing 15 2 2
MIRT657085 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT659793 CBLB Cbl proto-oncogene B 2 2
MIRT660155 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 2
MIRT662444 SERPINB5 serpin family B member 5 2 2
MIRT663116 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT665759 TMEM43 transmembrane protein 43 2 2
MIRT666357 SIKE1 suppressor of IKBKE 1 2 2
MIRT668521 ESRRG estrogen related receptor gamma 2 2
MIRT677776 FKTN fukutin 2 2
MIRT678900 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT702825 HOOK3 hook microtubule tethering protein 3 2 2
MIRT704424 CTNNBIP1 catenin beta interacting protein 1 2 2
MIRT709470 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT710939 MRPL45 mitochondrial ribosomal protein L45 2 2
MIRT713306 TYRP1 tyrosinase related protein 1 2 2
MIRT716932 FAM13A family with sequence similarity 13 member A 2 2
MIRT717539 PYGO2 pygopus family PHD finger 2 2 2
MIRT718060 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT718934 TRIM66 tripartite motif containing 66 2 2
MIRT719770 ZNF236 zinc finger protein 236 2 2
MIRT720164 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT721280 RAD54L2 RAD54 like 2 2 2
MIRT721359 ENTHD1 ENTH domain containing 1 2 2
MIRT721506 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721920 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722791 FUT4 fucosyltransferase 4 2 2
MIRT723933 SVOP SV2 related protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-5p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-2115-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-2115-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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