pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AASDHPPT   
Synonyms AASD-PPT, ACPS, CGI-80, LYS2, LYS5
Description aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Transcript NM_015423   
Expression
Putative miRNA Targets on AASDHPPT
3'UTR of AASDHPPT
(miRNA target sites are highlighted)
>AASDHPPT|NM_015423|3'UTR
   1 TGATTCCCTGAGTAACAAAGGGAAATGAAAACTGTTTGTGATCTTCCGTATTCACTGAAAAATAAATGCTTGTTTAGTAT
  81 CAAATTTTATTTCACGAAAGTTTTTTTAAAGAACAGAAACTTTTCCAATTAAAAAAAAAAAGCAGACTTCTGGTTCAAGA
 161 TAGCTCACTGGAATACATGTTTACCTCTTTCTTTCCTAAATTGCATTGAATTGATAGGAAGGATGGCGGAATCTTAAAGT
 241 GATACATGCTAACTGTAGAAAAAAATAGAAAATGCACATAAGCAAAAGGAAACATTTAAATGCTATCTTTCAAAGATAAC
 321 TACTCTTAAAACCTTGAGTATCTTTTCAGACCTTTTTCTTGGCAAATGAATCCATATTGACATATTTGATTTTTTTAAAA
 401 ACATGGAAACGTACTGTTTTGTAAATTCTTTTTAACTGCACATCTACTGTTCATAAATATACCTCTGTAACATAACTTTT
 481 TGTGGTTCTAATGTACTCTGTTGTATAGCTAATACAAGTTAGGATGCTTTTGGCCAGAGGTAACAGTGTCCAAATATAAT
 561 TGGCCTAAGTAACCTAGGAAATTGTTTGACATAACACAGGGTTCAGGGGTGTCATTAAAGACACACTTTTTTTGCCTTGA
 641 CCTCAGTTGGTTTGTTTTGCCTTAGGCTATTCCACCTCTCGATCACAAGAGCTGCTGCTATAACTTCCAGTTTTACATCT
 721 TTGTAAAATTGTATCTCAAAGGCAGAAAAGGCCATTTCGTCTCTCATTTGTTTTATCCATGAGGAAGATTTTTAACAAAA
 801 GCCTCCAGAAGATTTCCCCTCAGTTTCCATTGACTTAGATCAGGTTACAGAGAAAGGCAATGTCTGACATTTTTGGTCTC
 881 TGTTAGAAGTAGACTCTGTTGAAAAGAAAGAAGCTAAGCTAGGTGTGAAGAATGGAATTGGAAGCCCACTGCCTTCCCAT
 961 AAGAAAGGTTTACCATAATTTACTCACTTTTTTCTGTGTTAGACATTTTGATTATCTGCAGTTTATTACTACAAGCAGTG
1041 GCAGAGTGAATGTCCTTGTACATTTTGAGTTACATGCTTAATTATGTCCTTGAGAAAGTTTCTAAAAGTGGAATGATTGG
1121 TTTGACTGGTTCATAGGGCTTTAATTATACAATTTACCCCTCTAATTAGTACTATATGTATGTGACTTCCCTCCCCCTGC
1201 CAGAATACTCCTTGGTCAATTGTAGGTATTCTTTTTGGTTTAATTTTTGCCAATGTAATTAAAAAATGGTATGTCATTTT
1281 TAAAATTTGTATTTCTTTCATTACAAATAAGATTGTTATGTCAGTATTGTTATTGGCTTTTCGTATTCCTCTTAACGTGA
1361 ACCGTCTGTTCATTGTTTTTACCTGTTTTCGTTTTAGCAAGTAGTACTTAATTTAAAGTGTGAACTTAATATATAAGATG
1441 CCAGGACCATCATATTGATGACAAAAATCTATTATGTGGTTGTAGTGCATGTCTTGGAGTTAAACTCTTAAGTATCAAGA
1521 AGTAAAATAATTTCATTGTTTCTGTTACTAACATTAAAAGTGTGCAAATTGTATAAAATTAGGTACTTCGATTAGTAAAA
1601 GAAAAAAATTTGAATGTTTTTTTTTTTTATTTTATTAAGCATGCCCAGTTATGCCAAGCATAGTAAATAAAGGTCAAGTA
1681 GCATTTATAATAGAGGAAGTATTGTTATCCCTAGCATGAGTGTAATGGTGATATGAAAAACTTTGTCTTGTCATTATAAT
1761 AATAAAAAAATGAACATTTATTATGAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugcCG-AUCACCUG-GUCCACUUCa 5'
             || ||||  |:  |||| ||| 
Target 5' caaGCATAGTAAATAAAGGTCAAGt 3'
1655 - 1679 124.00 -10.40
2
miRNA  3' ugccgaucaccuggucCACUUCa 5'
                          |||||| 
Target 5' agaagctaagctaggtGTGAAGa 3'
909 - 931 120.00 -12.00
3
miRNA  3' ugcCGAUCACCUGGUC-CACUUca 5'
             || |||||  ||| |||||  
Target 5' caaGC-AGTGG--CAGAGTGAAtg 3'
1032 - 1052 115.00 -15.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30473754 54 COSMIC
COSN13298053 97 COSMIC
COSN30121939 100 COSMIC
COSN27309083 142 COSMIC
COSN30061369 159 COSMIC
COSN5295728 389 COSMIC
COSN20627237 568 COSMIC
COSN31778896 703 COSMIC
COSN8212860 741 COSMIC
COSN5256280 809 COSMIC
COSN16245767 1404 COSMIC
COSN22501508 1443 COSMIC
COSN9029946 1490 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772876329 1 dbSNP
rs766169452 10 dbSNP
rs368570555 11 dbSNP
rs754898031 12 dbSNP
rs1281479912 13 dbSNP
rs200693517 14 dbSNP
rs1430682833 15 dbSNP
rs1178844058 17 dbSNP
rs186476157 21 dbSNP
rs756129079 24 dbSNP
rs543573488 25 dbSNP
rs749483980 26 dbSNP
rs753886943 33 dbSNP
rs370423833 35 dbSNP
rs923258302 40 dbSNP
rs779310937 41 dbSNP
rs757295165 42 dbSNP
rs746432274 43 dbSNP
rs369569371 44 dbSNP
rs776069965 48 dbSNP
rs374891598 49 dbSNP
rs1326171940 51 dbSNP
rs1482553761 52 dbSNP
rs1272030874 55 dbSNP
rs1406736644 67 dbSNP
rs909811744 80 dbSNP
rs888048132 89 dbSNP
rs961212666 94 dbSNP
rs573652164 96 dbSNP
rs1036517251 97 dbSNP
rs1410490416 98 dbSNP
rs773915396 99 dbSNP
rs919342156 100 dbSNP
rs898017293 101 dbSNP
rs1403367802 103 dbSNP
rs938806217 109 dbSNP
rs1013748381 111 dbSNP
rs1057148585 115 dbSNP
rs544243871 116 dbSNP
rs1182348187 119 dbSNP
rs1471977778 126 dbSNP
rs1248903974 127 dbSNP
rs1940755 128 dbSNP
rs915879990 129 dbSNP
rs1485767324 131 dbSNP
rs368580660 131 dbSNP
rs948737043 131 dbSNP
rs562724196 132 dbSNP
rs904818696 142 dbSNP
rs533250072 165 dbSNP
rs72977072 168 dbSNP
rs999017419 172 dbSNP
rs957938545 180 dbSNP
rs1224973813 186 dbSNP
rs113901481 197 dbSNP
rs900916904 198 dbSNP
rs1160563492 206 dbSNP
rs1387861008 206 dbSNP
rs1211398136 210 dbSNP
rs1490278484 214 dbSNP
rs1472946409 217 dbSNP
rs181132335 228 dbSNP
rs866061106 229 dbSNP
rs1448512072 233 dbSNP
rs1248335033 241 dbSNP
rs185327669 243 dbSNP
rs773121274 244 dbSNP
rs1193180433 247 dbSNP
rs1235179292 248 dbSNP
rs567435411 256 dbSNP
rs923381072 267 dbSNP
rs1283815771 274 dbSNP
rs1445982321 279 dbSNP
rs931950553 283 dbSNP
rs147946690 284 dbSNP
rs1364597531 293 dbSNP
rs1016842745 295 dbSNP
rs1290415225 296 dbSNP
rs1435057161 301 dbSNP
rs909240748 306 dbSNP
rs189738400 315 dbSNP
rs1036654591 316 dbSNP
rs1293404944 326 dbSNP
rs533679053 327 dbSNP
rs1161095424 328 dbSNP
rs1248307275 342 dbSNP
rs551363423 352 dbSNP
rs1187652424 358 dbSNP
rs1463519469 358 dbSNP
rs1046548540 369 dbSNP
rs1254789041 370 dbSNP
rs183456565 371 dbSNP
rs1452261230 375 dbSNP
rs1274711131 377 dbSNP
rs960579794 382 dbSNP
rs1359017357 390 dbSNP
rs1228100880 397 dbSNP
rs539310369 397 dbSNP
rs1363721966 398 dbSNP
rs1031951797 404 dbSNP
rs1437721314 405 dbSNP
rs916015693 411 dbSNP
rs775187307 412 dbSNP
rs1370755014 414 dbSNP
rs554205961 417 dbSNP
rs1009433022 429 dbSNP
rs868621769 437 dbSNP
rs978763446 440 dbSNP
rs576712227 441 dbSNP
rs1396592509 442 dbSNP
rs1462229332 444 dbSNP
rs1477629419 445 dbSNP
rs1246235661 447 dbSNP
rs1219428093 448 dbSNP
rs1020836417 449 dbSNP
rs1183682655 457 dbSNP
rs1484189477 472 dbSNP
rs141764480 473 dbSNP
rs545706895 477 dbSNP
rs1053374571 489 dbSNP
rs762473708 490 dbSNP
rs1160907962 492 dbSNP
rs901301559 506 dbSNP
rs1367469111 507 dbSNP
rs976629826 514 dbSNP
rs1452836929 515 dbSNP
rs1287002891 519 dbSNP
rs145522053 522 dbSNP
rs1307033266 530 dbSNP
rs1377069460 534 dbSNP
rs1176471020 536 dbSNP
rs147804891 542 dbSNP
rs953472807 552 dbSNP
rs986238064 553 dbSNP
rs909209454 558 dbSNP
rs1473613032 560 dbSNP
rs1252543271 561 dbSNP
rs963405872 562 dbSNP
rs1181742810 563 dbSNP
rs1482167092 566 dbSNP
rs11226919 578 dbSNP
rs796295245 590 dbSNP
rs1258164134 591 dbSNP
rs1337480425 591 dbSNP
rs1211223888 592 dbSNP
rs1312170811 594 dbSNP
rs1277103092 595 dbSNP
rs1382214959 597 dbSNP
rs1450708654 609 dbSNP
rs889563504 621 dbSNP
rs1317865783 626 dbSNP
rs1238821542 627 dbSNP
rs1259427856 628 dbSNP
rs1407647048 629 dbSNP
rs1380849200 631 dbSNP
rs1303265854 637 dbSNP
rs1326285794 641 dbSNP
rs972271643 642 dbSNP
rs1357427837 645 dbSNP
rs1005208729 646 dbSNP
rs73537649 654 dbSNP
rs1457646384 660 dbSNP
rs148845850 661 dbSNP
rs1046546156 666 dbSNP
rs1258503429 670 dbSNP
rs1034959289 677 dbSNP
rs926810354 681 dbSNP
rs937762117 682 dbSNP
rs1053503843 687 dbSNP
rs1266985617 691 dbSNP
rs1156689731 696 dbSNP
rs1226020711 701 dbSNP
rs1022994275 702 dbSNP
rs751295883 703 dbSNP
rs1312985273 705 dbSNP
rs970148102 707 dbSNP
rs1231049250 708 dbSNP
rs552720387 720 dbSNP
rs1470252775 739 dbSNP
rs1175694442 740 dbSNP
rs978727558 741 dbSNP
rs1445964295 745 dbSNP
rs1320029889 751 dbSNP
rs761653022 756 dbSNP
rs577598024 759 dbSNP
rs1165754144 760 dbSNP
rs1391113787 764 dbSNP
rs545266531 780 dbSNP
rs1423415916 782 dbSNP
rs1190873359 789 dbSNP
rs1412119925 789 dbSNP
rs901101428 791 dbSNP
rs998537236 795 dbSNP
rs1206358529 796 dbSNP
rs1489179909 807 dbSNP
rs1265453778 818 dbSNP
rs989438890 823 dbSNP
rs1028138991 824 dbSNP
rs922896157 824 dbSNP
rs954053376 829 dbSNP
rs1286841210 834 dbSNP
rs1228839380 841 dbSNP
rs1364444959 842 dbSNP
rs1295305027 849 dbSNP
rs934128973 855 dbSNP
rs1392998440 858 dbSNP
rs1294150312 863 dbSNP
rs143466600 870 dbSNP
rs779905903 885 dbSNP
rs1170941291 889 dbSNP
rs1049949727 891 dbSNP
rs527446093 892 dbSNP
rs1389869539 894 dbSNP
rs889537501 894 dbSNP
rs1267475473 897 dbSNP
rs190756578 897 dbSNP
rs1007639985 903 dbSNP
rs1016364340 910 dbSNP
rs1190086838 920 dbSNP
rs548774582 923 dbSNP
rs1276317909 924 dbSNP
rs1038133164 931 dbSNP
rs972073533 936 dbSNP
rs1251474658 938 dbSNP
rs993868756 946 dbSNP
rs919281033 949 dbSNP
rs1175190990 951 dbSNP
rs1270762995 952 dbSNP
rs1331579951 958 dbSNP
rs750365556 968 dbSNP
rs1302129582 985 dbSNP
rs982813198 986 dbSNP
rs1035332279 988 dbSNP
rs1480670063 988 dbSNP
rs1198563281 991 dbSNP
rs1427153956 995 dbSNP
rs1412785723 1001 dbSNP
rs1430583893 1005 dbSNP
rs896438768 1012 dbSNP
rs1166474270 1015 dbSNP
rs566498170 1020 dbSNP
rs1012029887 1027 dbSNP
rs561001456 1030 dbSNP
rs938191013 1032 dbSNP
rs527363004 1034 dbSNP
rs1197614841 1040 dbSNP
rs1023462254 1062 dbSNP
rs549903043 1068 dbSNP
rs758462785 1073 dbSNP
rs1253260094 1075 dbSNP
rs183675852 1084 dbSNP
rs1000652680 1087 dbSNP
rs1042040851 1089 dbSNP
rs1249400564 1091 dbSNP
rs1306456724 1093 dbSNP
rs756193564 1100 dbSNP
rs1345706614 1114 dbSNP
rs998110957 1116 dbSNP
rs1230895020 1117 dbSNP
rs1321528405 1124 dbSNP
rs1290241117 1125 dbSNP
rs988851067 1129 dbSNP
rs1366136832 1133 dbSNP
rs922831685 1134 dbSNP
rs372530226 1138 dbSNP
rs1295670891 1144 dbSNP
rs955641700 1145 dbSNP
rs571600195 1158 dbSNP
rs889589614 1162 dbSNP
rs1413557604 1166 dbSNP
rs911359640 1175 dbSNP
rs941523891 1179 dbSNP
rs188134950 1181 dbSNP
rs1293545856 1185 dbSNP
rs1189442128 1193 dbSNP
rs918368475 1195 dbSNP
rs1016329373 1209 dbSNP
rs1255153052 1211 dbSNP
rs1198687406 1212 dbSNP
rs899236239 1216 dbSNP
rs994013063 1218 dbSNP
rs1266603115 1225 dbSNP
rs192927390 1226 dbSNP
rs566261083 1230 dbSNP
rs1187093875 1231 dbSNP
rs1247178175 1235 dbSNP
rs777752617 1242 dbSNP
rs184552615 1251 dbSNP
rs1333864296 1252 dbSNP
rs73537650 1254 dbSNP
rs982353209 1257 dbSNP
rs1320711726 1259 dbSNP
rs1405084450 1268 dbSNP
rs1456244937 1268 dbSNP
rs556033259 1269 dbSNP
rs1000722954 1276 dbSNP
rs1367714840 1277 dbSNP
rs1181489210 1283 dbSNP
rs1451304157 1285 dbSNP
rs1033492685 1288 dbSNP
rs1209511121 1290 dbSNP
rs537921147 1296 dbSNP
rs959506408 1299 dbSNP
rs956177440 1305 dbSNP
rs1282168396 1307 dbSNP
rs1211881018 1315 dbSNP
rs989618861 1316 dbSNP
rs1357268173 1318 dbSNP
rs1284024695 1319 dbSNP
rs80195741 1321 dbSNP
rs1029630096 1322 dbSNP
rs1302932314 1326 dbSNP
rs1342950817 1333 dbSNP
rs1348575573 1334 dbSNP
rs867893861 1343 dbSNP
rs577537432 1344 dbSNP
rs1360623642 1347 dbSNP
rs1225589758 1357 dbSNP
rs73537654 1358 dbSNP
rs978283667 1361 dbSNP
rs922284057 1364 dbSNP
rs933658327 1365 dbSNP
rs796381605 1391 dbSNP
rs757621650 1392 dbSNP
rs1452466943 1395 dbSNP
rs1291315698 1396 dbSNP
rs1216370191 1403 dbSNP
rs1241475561 1408 dbSNP
rs889722215 1411 dbSNP
rs1344778367 1422 dbSNP
rs941288432 1426 dbSNP
rs541472313 1431 dbSNP
rs929783148 1432 dbSNP
rs1038192275 1434 dbSNP
rs917546685 1450 dbSNP
rs1436550692 1456 dbSNP
rs150930147 1459 dbSNP
rs1300905714 1465 dbSNP
rs7554 1468 dbSNP
rs1370960283 1479 dbSNP
rs1167684700 1483 dbSNP
rs1026826891 1489 dbSNP
rs1427166057 1513 dbSNP
rs1174459561 1525 dbSNP
rs1478400800 1534 dbSNP
rs1268200416 1536 dbSNP
rs1160420390 1539 dbSNP
rs906497709 1545 dbSNP
rs1197568057 1551 dbSNP
rs1044935754 1554 dbSNP
rs1345141199 1566 dbSNP
rs574923807 1567 dbSNP
rs140657313 1574 dbSNP
rs1306324459 1582 dbSNP
rs1281338972 1587 dbSNP
rs1003973516 1590 dbSNP
rs1280751895 1591 dbSNP
rs1411311644 1592 dbSNP
rs1307246228 1602 dbSNP
rs1350694039 1602 dbSNP
rs1439748836 1603 dbSNP
rs1360617689 1610 dbSNP
rs1033862854 1611 dbSNP
rs1413792524 1615 dbSNP
rs1428722911 1615 dbSNP
rs1174332459 1616 dbSNP
rs891872342 1616 dbSNP
rs1239516518 1617 dbSNP
rs1479864030 1617 dbSNP
rs370229857 1617 dbSNP
rs58915339 1617 dbSNP
rs878949853 1617 dbSNP
rs959600737 1623 dbSNP
rs989712198 1624 dbSNP
rs1048683 1625 dbSNP
rs1229673794 1625 dbSNP
rs966883492 1629 dbSNP
rs1224148349 1630 dbSNP
rs1221661556 1632 dbSNP
rs1283395633 1635 dbSNP
rs1326997790 1641 dbSNP
rs1381103342 1642 dbSNP
rs1029765899 1652 dbSNP
rs1245035763 1660 dbSNP
rs1451879636 1660 dbSNP
rs1334868934 1666 dbSNP
rs891109142 1672 dbSNP
rs1389378459 1673 dbSNP
rs1461870631 1686 dbSNP
rs1158670136 1688 dbSNP
rs1328617032 1691 dbSNP
rs118065945 1697 dbSNP
rs1182772410 1698 dbSNP
rs922345759 1701 dbSNP
rs933647465 1707 dbSNP
rs1241830752 1709 dbSNP
rs963028763 1711 dbSNP
rs1464969278 1713 dbSNP
rs144891342 1715 dbSNP
rs1178153437 1718 dbSNP
rs1407811279 1722 dbSNP
rs1323116302 1727 dbSNP
rs1313229200 1730 dbSNP
rs1025769631 1742 dbSNP
rs1456099648 1743 dbSNP
rs951637344 1745 dbSNP
rs1406133350 1751 dbSNP
rs1468860692 1753 dbSNP
rs910914297 1755 dbSNP
rs1331732484 1762 dbSNP
rs991840135 1764 dbSNP
rs138744064 1771 dbSNP
rs1451946577 1771 dbSNP
rs1351811983 1776 dbSNP
rs941256007 1777 dbSNP
rs917682489 1784 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000278618.4 | 3UTR | GAAUGGAAUUGGAAGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000278618.4 | 3UTR | AAUGGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000278618.4 | 3UTR | GAAUGGAAUUGGAAGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000278618.4 | 3UTR | GAAUGGAAUUGGAAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000278618.4 | 3UTR | GUGUGAAGAAUGGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000278618.4 | 3UTR | AAUGGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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