pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MARCH2   
Synonyms HSPC240, MARCH-II, RNF172
Description membrane associated ring-CH-type finger 2
Transcript NM_001005415   
Other Transcripts NM_001005416 , NM_016496   
Expression
Putative miRNA Targets on MARCH2
3'UTR of MARCH2
(miRNA target sites are highlighted)
>MARCH2|NM_001005415|3'UTR
   1 ATGCTGGGCTCTCCGGACCCTGCAGCAGAGAGGCCAGAGGTAGCTGGTGATACCCTGTCCTGTGGAAGGACTTCCACTTC
  81 AACACTTCCACTTCAACAGTTCCCGCACGGCCTGAACGCTTCTTAGGCCAAGAGACACCATGCAGAGCCTAGTCTGTGAT
 161 CCTGTGTGAAGATATTTTCAGGGTTTTTTTTTTTTTTTTTTTGCATATGGAGGACAGGTGGACATGGTCCTGAGCTCTGG
 241 ACGGAGCAGGCACCCTGATCTCATTCTGAGGTCCACATGGCACCTTCTGGGCCAGCAGCTGTGGCCGGTGTATCAAGGGC
 321 GCCCTTAAAGCTGGAACATTCCAGCAAGCTTCTTGCGCTTCTCTGCACCCGGCAGGCCCACTTTCCTGGCACCCTCGACT
 401 TTATATAAAAGTTGCACTGCGTTTCAAAAACCCACCCCTGAATGAATAAAAGGAGCCCTGGCTGGACAAAAAAAAAAAAA
 481 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugCCGAUC--AC-CU-GGUC-CACUUCa 5'
            | ||||  || || || | |||||| 
Target 5' gaGCCTAGTCTGTGATCCTGTGTGAAGa 3'
145 - 172 131.00 -14.60
2
miRNA  3' ugccgAUCACCUGGUCCACUUca 5'
               |:| ||| ||||||:|  
Target 5' gcataTGGAGGA-CAGGTGGAca 3'
203 - 224 129.00 -16.10
3
miRNA  3' ugCCGAUCACC-UGGUCCACUuca 5'
            ||| || || | | |||||   
Target 5' gaGGCCAGAGGTAGCTGGTGAtac 3'
30 - 53 125.00 -14.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30490506 15 COSMIC
COSN30526143 17 COSMIC
COSN30122417 35 COSMIC
COSN16896550 63 COSMIC
COSN31511512 64 COSMIC
COSN28789688 99 COSMIC
COSN31583079 106 COSMIC
COSN31532231 134 COSMIC
COSN28469678 191 COSMIC
COSN20079551 193 COSMIC
COSN20079378 194 COSMIC
COSN27536972 203 COSMIC
COSN17829609 235 COSMIC
COSN27696379 267 COSMIC
COSN16155790 284 COSMIC
COSN30173584 321 COSMIC
COSN31482476 322 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1229280663 10 dbSNP
rs1455075824 13 dbSNP
rs368150127 14 dbSNP
rs769714910 15 dbSNP
rs773136104 16 dbSNP
rs1453238850 19 dbSNP
rs999401195 26 dbSNP
rs763040085 29 dbSNP
rs770968286 31 dbSNP
rs942217360 32 dbSNP
rs370919367 33 dbSNP
rs758749767 35 dbSNP
rs1428948984 37 dbSNP
rs1206752767 41 dbSNP
rs375801749 45 dbSNP
rs1405765228 49 dbSNP
rs760837249 51 dbSNP
rs948528857 54 dbSNP
rs1161661828 56 dbSNP
rs1451236471 61 dbSNP
rs143629061 70 dbSNP
rs1213456049 72 dbSNP
rs187578553 76 dbSNP
rs921856395 81 dbSNP
rs1484584266 83 dbSNP
rs911812382 86 dbSNP
rs932624437 86 dbSNP
rs891051932 97 dbSNP
rs1053054249 105 dbSNP
rs1359182722 109 dbSNP
rs535075603 110 dbSNP
rs529645897 118 dbSNP
rs1343472197 126 dbSNP
rs1295002087 132 dbSNP
rs543220384 137 dbSNP
rs11259981 145 dbSNP
rs1294344223 149 dbSNP
rs1404561390 153 dbSNP
rs191581305 162 dbSNP
rs1431594109 168 dbSNP
rs1390742990 181 dbSNP
rs1169594775 182 dbSNP
rs1248823584 182 dbSNP
rs140893509 183 dbSNP
rs1191479517 184 dbSNP
rs1225806809 184 dbSNP
rs1251268775 184 dbSNP
rs1267272152 184 dbSNP
rs1483566062 184 dbSNP
rs370862443 184 dbSNP
rs1314085246 185 dbSNP
rs1184820822 186 dbSNP
rs1427940892 187 dbSNP
rs1223179925 188 dbSNP
rs1030792770 189 dbSNP
rs1411454179 191 dbSNP
rs954742265 191 dbSNP
rs1055554 192 dbSNP
rs530810099 193 dbSNP
rs1460402412 194 dbSNP
rs1360449132 196 dbSNP
rs1176495230 199 dbSNP
rs1479929550 203 dbSNP
rs1404405985 204 dbSNP
rs1459111745 205 dbSNP
rs1473132538 206 dbSNP
rs1322194239 208 dbSNP
rs1250249591 214 dbSNP
rs903039781 220 dbSNP
rs1194646085 221 dbSNP
rs963623068 225 dbSNP
rs1256701774 226 dbSNP
rs1429498830 227 dbSNP
rs768272265 238 dbSNP
rs776075619 243 dbSNP
rs367944537 244 dbSNP
rs567208060 251 dbSNP
rs1336200402 253 dbSNP
rs1306009931 256 dbSNP
rs1369022518 257 dbSNP
rs928855118 259 dbSNP
rs1381215852 271 dbSNP
rs938948980 274 dbSNP
rs948219208 278 dbSNP
rs536170735 282 dbSNP
rs1468857645 283 dbSNP
rs991423982 285 dbSNP
rs1055551 288 dbSNP
rs112288235 304 dbSNP
rs1403197624 307 dbSNP
rs1044155939 308 dbSNP
rs1453981903 313 dbSNP
rs915879020 314 dbSNP
rs947438674 315 dbSNP
rs1052791477 319 dbSNP
rs1257510284 319 dbSNP
rs1043526842 321 dbSNP
rs903306463 322 dbSNP
rs935121181 324 dbSNP
rs1217414834 328 dbSNP
rs1210333424 330 dbSNP
rs1052276466 338 dbSNP
rs891020773 341 dbSNP
rs1008167852 342 dbSNP
rs1042992451 344 dbSNP
rs73925332 347 dbSNP
rs899486006 352 dbSNP
rs996378291 354 dbSNP
rs755024482 357 dbSNP
rs995220485 358 dbSNP
rs1382470600 361 dbSNP
rs1055546 364 dbSNP
rs1383825535 365 dbSNP
rs1156396710 367 dbSNP
rs1199358695 370 dbSNP
rs577866357 371 dbSNP
rs182613103 372 dbSNP
rs1014907797 373 dbSNP
rs1055545 381 dbSNP
rs538829097 385 dbSNP
rs1443313896 397 dbSNP
rs1004307468 402 dbSNP
rs1193953642 403 dbSNP
rs1035836912 406 dbSNP
rs558365587 419 dbSNP
rs187279920 421 dbSNP
rs192041701 422 dbSNP
rs1211804861 426 dbSNP
rs973667219 426 dbSNP
rs1315703383 433 dbSNP
rs916199594 434 dbSNP
rs1055544 435 dbSNP
rs35091049 435 dbSNP
rs200268942 436 dbSNP
rs1404975126 439 dbSNP
rs1299675778 441 dbSNP
rs1227544622 443 dbSNP
rs1325292170 448 dbSNP
rs574121751 455 dbSNP
rs774301044 458 dbSNP
rs1366642967 462 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000602117.1 | 3UTR | UGAAGAUAUUUUCAGGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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