pre-miRNA Information
pre-miRNA hsa-mir-4419b   
Genomic Coordinates chr12: 128244506 - 128244573
Description Homo sapiens miR-4419b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4419b
Sequence 42| GAGGCUGAAGGAAGAUGG |59
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF665   
Synonyms ZFP160L
Description zinc finger protein 665
Transcript NM_024733   
Expression
Putative miRNA Targets on ZNF665
3'UTR of ZNF665
(miRNA target sites are highlighted)
>ZNF665|NM_024733|3'UTR
   1 AAACCTTACAAAGGACGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGGGGATCACC
  81 TGAGGTCTCGAGTTCGAGACCAGGCTGGCCAACACGGTGAAACGCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGT
 161 GGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAG
 241 TGAGCGAGATCATGCCATTGCACTCCAGCCTGGGCAACAGGAGTGAAACTCCATCTCCAAAAAAAAAAAAAAAAAAAAAG
 321 TAACCTTACAAAGGAGTGCGGCCAGTTTTTCAGCCACAAATTCTTTCACAACATCAGAGAATTCATTCTTGAGACAATTC
 401 TTACAAATACAGTGACTGTGGCAAACTCCTGATGAGTTTAAGCATTAACAGACATCAGAGTTCAAATCCTGTGAATATAC
 481 TATGTATGACAGAAGCTTTATCCAGGTCTCAGAGCTCAATACGCATCAAAAGATACATCTTTGATGAAGTCACACAAACG
 561 TAACATGCATGCTGAGACTATTACTCCTGGACCACAACTGTAGGTGAGGATTCATAGGAAGAGTAGAACTCAGTCTCTAG
 641 TTTCCTCATAACCCTCTGATATTATATACTTCAGCATAATCAGAAGTCCAAATGTGTTAAAACTCATTACATGATACATA
 721 TCAAAGGTTGTAGGATGTTTGGAAATGGCCAATTACTTTCAGCTTATAAAATGTTTTGTTGAAGTATTTAAGATTTATTG
 801 AAAAGGCTACTATTTATAACTTCCAACCAGAACTTTGCAATGTGCTGATTTTATACATGATTATACGCCTAACATGGTGT
 881 TGTTCGGGAAAGAATCAAAGGATGGAAGGGCTCACTCACTTCATTAGGTGAGGATTATTTCTCTCCAAGCTCCTGAAGAA
 961 AAAAGACTCTGCCTTTTAAAATTAAATATAGTCTGAATTAGAGAGCACTTGGAAAGGGCAGAGGATGATGAACTATGATG
1041 TCACTCATCATCCTTATTGCACTGCAGGTGCCCTTCTTCTGACAGAAGAGCACTGTGGGTATGGGAAGAAATTCTCTACT
1121 GGCCGGGCACAGTGGCTCACGCCTGTAATGCCAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggUAGAAGGAAGUCGGAg 5'
            | :| |:||||||:| 
Target 5' ccAATTACTTTCAGCTTa 3'
749 - 766 140.00 -14.30
2
miRNA  3' gguagaAGGAAGUCGGag 5'
                |::|||||||  
Target 5' ggccagTTTTTCAGCCac 3'
340 - 357 132.00 -16.10
3
miRNA  3' gguagaaggaAGUCGGAg 5'
                    ||||:|| 
Target 5' agagtagaacTCAGTCTc 3'
620 - 637 124.00 -10.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30162044 17 COSMIC
COSN13826472 20 COSMIC
COSN30496225 23 COSMIC
COSN13826469 24 COSMIC
COSN31625600 34 COSMIC
COSN30122221 35 COSMIC
COSN30169704 36 COSMIC
COSN31534032 38 COSMIC
COSN18742371 69 COSMIC
COSN30477104 95 COSMIC
COSN31593097 113 COSMIC
COSN13826462 115 COSMIC
COSN18776711 299 COSMIC
COSN20844791 339 COSMIC
COSN24744345 435 COSMIC
COSN25349964 720 COSMIC
COSN26724973 779 COSMIC
COSN26804165 991 COSMIC
COSN32057012 1023 COSMIC
COSN7449103 1140 COSMIC
COSN20864462 1189 COSMIC
COSN19408741 1350 COSMIC
COSN29573333 1402 COSMIC
COSN25509035 1430 COSMIC
COSN8975654 1716 COSMIC
COSN28897973 1822 COSMIC
COSN16060695 1871 COSMIC
COSN5761839 1994 COSMIC
rs1133146 1046 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775879844 5 dbSNP
rs1020110499 9 dbSNP
rs772509712 10 dbSNP
rs746229652 13 dbSNP
rs1230012080 16 dbSNP
rs548473021 16 dbSNP
rs1051450672 17 dbSNP
rs771542547 19 dbSNP
rs749799035 20 dbSNP
rs138817165 21 dbSNP
rs144934242 22 dbSNP
rs751163511 23 dbSNP
rs550775146 24 dbSNP
rs1271154011 25 dbSNP
rs1198025272 32 dbSNP
rs1042794479 33 dbSNP
rs758115625 35 dbSNP
rs532688642 36 dbSNP
rs1378878328 40 dbSNP
rs765068450 45 dbSNP
rs1450671103 47 dbSNP
rs1360461883 50 dbSNP
rs1249774654 54 dbSNP
rs565270654 58 dbSNP
rs915708751 63 dbSNP
rs1198179036 64 dbSNP
rs547064598 64 dbSNP
rs528499519 68 dbSNP
rs4803054 69 dbSNP
rs919648598 70 dbSNP
rs192743148 72 dbSNP
rs1322993041 73 dbSNP
rs928538024 74 dbSNP
rs1299979516 76 dbSNP
rs1429544145 79 dbSNP
rs1207576681 86 dbSNP
rs1283575359 88 dbSNP
rs1329160250 89 dbSNP
rs974161961 90 dbSNP
rs958368293 95 dbSNP
rs749065447 96 dbSNP
rs1453439321 97 dbSNP
rs1200268414 99 dbSNP
rs1411446326 100 dbSNP
rs951347588 105 dbSNP
rs1161740032 109 dbSNP
rs1457829314 114 dbSNP
rs372038384 115 dbSNP
rs190045639 116 dbSNP
rs1303258510 117 dbSNP
rs1349437919 118 dbSNP
rs1363314292 118 dbSNP
rs1226195059 119 dbSNP
rs1320068069 120 dbSNP
rs1308875403 123 dbSNP
rs755756449 124 dbSNP
rs1010038732 126 dbSNP
rs1243952467 127 dbSNP
rs957445121 131 dbSNP
rs184566348 132 dbSNP
rs964257246 133 dbSNP
rs1018887210 134 dbSNP
rs1304569064 136 dbSNP
rs1439092443 142 dbSNP
rs1332399400 154 dbSNP
rs146632398 156 dbSNP
rs543892284 157 dbSNP
rs1370632492 158 dbSNP
rs1423634494 161 dbSNP
rs1163160768 170 dbSNP
rs900524537 171 dbSNP
rs1040776442 173 dbSNP
rs1009139940 185 dbSNP
rs755573737 190 dbSNP
rs1042848694 191 dbSNP
rs947098126 197 dbSNP
rs1187536526 203 dbSNP
rs1169992460 209 dbSNP
rs1373644006 212 dbSNP
rs1432730942 213 dbSNP
rs10427112 214 dbSNP
rs558231972 229 dbSNP
rs549945629 230 dbSNP
rs1273993654 234 dbSNP
rs1340192103 238 dbSNP
rs898249930 239 dbSNP
rs376363633 244 dbSNP
rs572810529 245 dbSNP
rs937066243 246 dbSNP
rs927017194 253 dbSNP
rs981095590 262 dbSNP
rs1248642367 271 dbSNP
rs7260409 280 dbSNP
rs1445763913 295 dbSNP
rs1297222283 296 dbSNP
rs1229391248 298 dbSNP
rs1328326155 299 dbSNP
rs1491476170 299 dbSNP
rs949956329 299 dbSNP
rs1491122280 300 dbSNP
rs982621716 300 dbSNP
rs1299326482 308 dbSNP
rs1465234133 312 dbSNP
rs1386236785 318 dbSNP
rs1384795389 319 dbSNP
rs1208365607 320 dbSNP
rs1208621383 320 dbSNP
rs1216356828 320 dbSNP
rs1224066614 320 dbSNP
rs1228442407 320 dbSNP
rs1265375079 320 dbSNP
rs1296402278 320 dbSNP
rs1311758846 320 dbSNP
rs1362980282 320 dbSNP
rs1432222437 320 dbSNP
rs1453256892 320 dbSNP
rs35735454 320 dbSNP
rs764331903 320 dbSNP
rs774279031 320 dbSNP
rs775717687 320 dbSNP
rs146187673 322 dbSNP
rs1173579816 332 dbSNP
rs1407987550 338 dbSNP
rs951400212 339 dbSNP
rs919897949 340 dbSNP
rs12985467 349 dbSNP
rs12986080 355 dbSNP
rs1367072258 356 dbSNP
rs1217669956 359 dbSNP
rs192315888 367 dbSNP
rs1368457636 370 dbSNP
rs1228104110 374 dbSNP
rs1018356793 387 dbSNP
rs1033240101 388 dbSNP
rs1383506537 395 dbSNP
rs201806685 401 dbSNP
rs965147584 404 dbSNP
rs1449669507 410 dbSNP
rs12972121 411 dbSNP
rs1196689922 412 dbSNP
rs1430909720 414 dbSNP
rs762010738 422 dbSNP
rs1158060974 432 dbSNP
rs1409567744 446 dbSNP
rs1196157629 447 dbSNP
rs776759119 448 dbSNP
rs1402361791 453 dbSNP
rs1318959696 473 dbSNP
rs955492230 478 dbSNP
rs886708615 479 dbSNP
rs1026498363 480 dbSNP
rs768693212 482 dbSNP
rs1305058096 486 dbSNP
rs1346310119 493 dbSNP
rs902866361 494 dbSNP
rs1286830826 496 dbSNP
rs1225357450 497 dbSNP
rs1224794997 499 dbSNP
rs899356423 500 dbSNP
rs1055701243 508 dbSNP
rs937141798 511 dbSNP
rs1219550050 515 dbSNP
rs1011224460 520 dbSNP
rs6509729 522 dbSNP
rs1206266436 533 dbSNP
rs12971840 535 dbSNP
rs1471064578 536 dbSNP
rs938519568 543 dbSNP
rs6509728 559 dbSNP
rs1046978096 565 dbSNP
rs1409412005 575 dbSNP
rs12971799 580 dbSNP
rs1337785903 581 dbSNP
rs543641475 586 dbSNP
rs1443321076 591 dbSNP
rs1331756134 597 dbSNP
rs151291979 598 dbSNP
rs1283918296 599 dbSNP
rs777649455 618 dbSNP
rs1248889319 630 dbSNP
rs935913478 638 dbSNP
rs925842122 640 dbSNP
rs1359596278 644 dbSNP
rs1203966000 647 dbSNP
rs974947063 648 dbSNP
rs867568395 652 dbSNP
rs1296106532 654 dbSNP
rs1439220092 656 dbSNP
rs1182190980 661 dbSNP
rs964825654 668 dbSNP
rs1018959015 669 dbSNP
rs987444082 673 dbSNP
rs950750608 682 dbSNP
rs1026257408 683 dbSNP
rs995140479 685 dbSNP
rs755885420 686 dbSNP
rs1033861863 694 dbSNP
rs1398197565 698 dbSNP
rs1333920926 700 dbSNP
rs576346889 713 dbSNP
rs73057857 722 dbSNP
rs1365147464 734 dbSNP
rs544868610 737 dbSNP
rs1429364462 742 dbSNP
rs978244701 752 dbSNP
rs1267915718 757 dbSNP
rs1471877788 764 dbSNP
rs1045536420 765 dbSNP
rs1341028693 766 dbSNP
rs1196072694 767 dbSNP
rs1013994210 770 dbSNP
rs1459841528 778 dbSNP
rs1205364883 782 dbSNP
rs891505631 790 dbSNP
rs1183372596 793 dbSNP
rs968315231 794 dbSNP
rs117069309 796 dbSNP
rs935940063 801 dbSNP
rs1404326269 805 dbSNP
rs1471139709 807 dbSNP
rs1200082391 810 dbSNP
rs1337832811 812 dbSNP
rs1388477304 817 dbSNP
rs1381031972 825 dbSNP
rs1315593782 831 dbSNP
rs894099988 837 dbSNP
rs925821885 840 dbSNP
rs1227658612 841 dbSNP
rs545148675 848 dbSNP
rs34751425 866 dbSNP
rs1225056335 867 dbSNP
rs906947896 867 dbSNP
rs1464384949 870 dbSNP
rs1046902772 871 dbSNP
rs1263918374 873 dbSNP
rs1198292829 877 dbSNP
rs367717505 877 dbSNP
rs1327022689 885 dbSNP
rs1481550974 886 dbSNP
rs1177523099 892 dbSNP
rs187877009 913 dbSNP
rs911715784 917 dbSNP
rs539960910 918 dbSNP
rs1452231644 919 dbSNP
rs987542375 923 dbSNP
rs898439732 930 dbSNP
rs1382248273 932 dbSNP
rs1442664568 946 dbSNP
rs1337305957 951 dbSNP
rs140353084 953 dbSNP
rs1406460180 955 dbSNP
rs1133145 961 dbSNP
rs1406221261 967 dbSNP
rs973779362 970 dbSNP
rs987303636 971 dbSNP
rs1262380063 973 dbSNP
rs769060927 986 dbSNP
rs1209259894 988 dbSNP
rs1266873265 989 dbSNP
rs1490901615 993 dbSNP
rs1200475412 994 dbSNP
rs1251505436 997 dbSNP
rs934094741 1006 dbSNP
rs963666194 1006 dbSNP
rs1364819924 1017 dbSNP
rs542548575 1035 dbSNP
rs575542318 1036 dbSNP
rs1162370852 1038 dbSNP
rs1034323993 1044 dbSNP
rs1133146 1046 dbSNP
rs1411881954 1052 dbSNP
rs1303423802 1053 dbSNP
rs970908168 1056 dbSNP
rs568635891 1062 dbSNP
rs538798098 1064 dbSNP
rs1308901092 1068 dbSNP
rs1336210521 1070 dbSNP
rs1245244593 1072 dbSNP
rs1289650652 1076 dbSNP
rs1025145295 1085 dbSNP
rs758872511 1107 dbSNP
rs571483703 1116 dbSNP
rs1014046380 1120 dbSNP
rs553477567 1124 dbSNP
rs1052788776 1125 dbSNP
rs1179249397 1126 dbSNP
rs550106742 1127 dbSNP
rs1423729199 1128 dbSNP
rs373886917 1136 dbSNP
rs1039389314 1138 dbSNP
rs756568762 1140 dbSNP
rs567540022 1141 dbSNP
rs991062608 1145 dbSNP
rs943284565 1148 dbSNP
rs1236068883 1149 dbSNP
rs1187158933 1150 dbSNP
rs1460157490 1154 dbSNP
rs1299669213 1157 dbSNP
rs958626083 1160 dbSNP
rs1443247900 1161 dbSNP
rs1245142586 1162 dbSNP
rs1312776098 1165 dbSNP
rs1206915808 1173 dbSNP
rs911768111 1177 dbSNP
rs1051541004 1183 dbSNP
rs1196412250 1184 dbSNP
rs147575004 1188 dbSNP
rs919304979 1190 dbSNP
rs973448076 1192 dbSNP
rs1352633004 1193 dbSNP
rs1282180154 1200 dbSNP
rs963680393 1201 dbSNP
rs1243742574 1214 dbSNP
rs907000267 1218 dbSNP
rs1338221452 1219 dbSNP
rs1432345509 1221 dbSNP
rs1245458158 1224 dbSNP
rs11668679 1227 dbSNP
rs1319617741 1228 dbSNP
rs570721348 1229 dbSNP
rs1418260218 1232 dbSNP
rs981469161 1240 dbSNP
rs970960239 1247 dbSNP
rs1373319157 1254 dbSNP
rs1163068152 1259 dbSNP
rs1445553393 1261 dbSNP
rs1025155133 1262 dbSNP
rs1009698576 1263 dbSNP
rs1453368737 1266 dbSNP
rs1288349733 1268 dbSNP
rs1186901537 1270 dbSNP
rs12977280 1271 dbSNP
rs1006780184 1274 dbSNP
rs1339735014 1276 dbSNP
rs1242752123 1295 dbSNP
rs1216459377 1301 dbSNP
rs1448691582 1303 dbSNP
rs192593712 1305 dbSNP
rs889690097 1308 dbSNP
rs1209028884 1310 dbSNP
rs1359883837 1314 dbSNP
rs1316785545 1316 dbSNP
rs1225704741 1317 dbSNP
rs1363884652 1323 dbSNP
rs999932357 1324 dbSNP
rs904213512 1326 dbSNP
rs1017270235 1327 dbSNP
rs1173981308 1328 dbSNP
rs139803535 1332 dbSNP
rs890340116 1334 dbSNP
rs1470233686 1336 dbSNP
rs1042454842 1341 dbSNP
rs1323397081 1342 dbSNP
rs559547709 1350 dbSNP
rs991380895 1351 dbSNP
rs1403411828 1357 dbSNP
rs187675394 1359 dbSNP
rs1167001916 1360 dbSNP
rs1324782954 1368 dbSNP
rs1282705391 1372 dbSNP
rs897928297 1379 dbSNP
rs1392603283 1386 dbSNP
rs528230014 1388 dbSNP
rs1038220353 1389 dbSNP
rs981106692 1390 dbSNP
rs1420443615 1391 dbSNP
rs1025351881 1394 dbSNP
rs993856371 1395 dbSNP
rs1176432030 1402 dbSNP
rs1405630360 1404 dbSNP
rs942124527 1406 dbSNP
rs1188380813 1408 dbSNP
rs1159923775 1410 dbSNP
rs1477044736 1411 dbSNP
rs1244979645 1416 dbSNP
rs962875699 1418 dbSNP
rs757922937 1422 dbSNP
rs1007119311 1426 dbSNP
rs1346407247 1429 dbSNP
rs560719597 1432 dbSNP
rs980762291 1433 dbSNP
rs372398522 1437 dbSNP
rs1376158711 1438 dbSNP
rs762064199 1439 dbSNP
rs1224882523 1451 dbSNP
rs1286081485 1458 dbSNP
rs1358155265 1463 dbSNP
rs1051000947 1464 dbSNP
rs752352474 1466 dbSNP
rs998196419 1471 dbSNP
rs1215816739 1472 dbSNP
rs1231031584 1476 dbSNP
rs1364866622 1488 dbSNP
rs918148302 1494 dbSNP
rs1042507067 1533 dbSNP
rs1384657831 1537 dbSNP
rs1442803655 1546 dbSNP
rs1165558725 1552 dbSNP
rs988320124 1563 dbSNP
rs1409672882 1568 dbSNP
rs144589625 1570 dbSNP
rs1347824921 1578 dbSNP
rs1055336595 1579 dbSNP
rs1306596203 1582 dbSNP
rs1429457155 1584 dbSNP
rs1355343195 1585 dbSNP
rs1172802305 1587 dbSNP
rs1307019466 1601 dbSNP
rs1316541119 1601 dbSNP
rs1356609181 1601 dbSNP
rs146693184 1601 dbSNP
rs556086994 1602 dbSNP
rs1270600084 1607 dbSNP
rs1439389704 1608 dbSNP
rs1199076221 1609 dbSNP
rs1412897706 1614 dbSNP
rs1459926491 1626 dbSNP
rs1032490729 1631 dbSNP
rs978960353 1634 dbSNP
rs1369184118 1635 dbSNP
rs928226666 1645 dbSNP
rs1166410813 1649 dbSNP
rs968491987 1656 dbSNP
rs1198658780 1659 dbSNP
rs971057470 1660 dbSNP
rs1404459030 1664 dbSNP
rs1480743480 1665 dbSNP
rs1017698301 1668 dbSNP
rs1338116297 1671 dbSNP
rs1340607087 1675 dbSNP
rs1007142827 1685 dbSNP
rs1268008321 1701 dbSNP
rs972797166 1715 dbSNP
rs962518050 1729 dbSNP
rs1017095124 1731 dbSNP
rs890392461 1733 dbSNP
rs1480147514 1739 dbSNP
rs183076648 1740 dbSNP
rs993362616 1743 dbSNP
rs1244003481 1761 dbSNP
rs1029602199 1768 dbSNP
rs563542431 1771 dbSNP
rs1309978234 1779 dbSNP
rs897691433 1780 dbSNP
rs1427710202 1783 dbSNP
rs559432548 1789 dbSNP
rs1223549741 1793 dbSNP
rs942115788 1802 dbSNP
rs1286937228 1803 dbSNP
rs902415942 1823 dbSNP
rs540646645 1824 dbSNP
rs1400285959 1825 dbSNP
rs764332142 1829 dbSNP
rs1343450674 1833 dbSNP
rs191224558 1835 dbSNP
rs893924733 1837 dbSNP
rs1349887269 1847 dbSNP
rs1374496094 1852 dbSNP
rs78350936 1856 dbSNP
rs375017838 1857 dbSNP
rs935568512 1858 dbSNP
rs1199035839 1867 dbSNP
rs925480199 1870 dbSNP
rs1481602379 1872 dbSNP
rs979591981 1874 dbSNP
rs574029755 1876 dbSNP
rs929589518 1877 dbSNP
rs1452334937 1880 dbSNP
rs1017332277 1881 dbSNP
rs369885604 1885 dbSNP
rs941018990 1893 dbSNP
rs954407210 1896 dbSNP
rs1156848934 1900 dbSNP
rs1343279725 1902 dbSNP
rs1388237826 1916 dbSNP
rs1301725059 1923 dbSNP
rs1418341362 1928 dbSNP
rs1250940154 1931 dbSNP
rs1029935974 1936 dbSNP
rs1281332306 1937 dbSNP
rs1354555686 1942 dbSNP
rs1221887612 1950 dbSNP
rs1482089224 1955 dbSNP
rs1490907082 1957 dbSNP
rs909642627 1960 dbSNP
rs111333211 1968 dbSNP
rs1417826297 1975 dbSNP
rs953870402 1977 dbSNP
rs1203767601 1986 dbSNP
rs1439721239 1995 dbSNP
rs1162392543 2004 dbSNP
rs569736116 2006 dbSNP
rs1363256508 2017 dbSNP
rs1266846836 2018 dbSNP
rs1238934133 2026 dbSNP
rs1029528865 2027 dbSNP
rs1317941752 2028 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ggUAGAAGGA---AGUCGGAg 5'
            ||: ||||   ||||||| 
Target 5' cgAUUCUCCUGCCUCAGCCUc 3'
7 - 27
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000600412.1 | 3UTR | UUUUAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000600412.1 | 3UTR | UUUAGCGAUUCUCCUGCCUCAGCCUCCCAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
390 hsa-miR-4419b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061343 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT072743 GLCE glucuronic acid epimerase 2 2
MIRT180549 TXNIP thioredoxin interacting protein 2 2
MIRT186147 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT271044 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT334761 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 6
MIRT443279 TSPAN15 tetraspanin 15 2 2
MIRT447047 ZNF439 zinc finger protein 439 2 2
MIRT447351 KIF6 kinesin family member 6 2 2
MIRT448925 CKS1B CDC28 protein kinase regulatory subunit 1B 2 2
MIRT452899 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT453087 SUMF2 sulfatase modifying factor 2 2 2
MIRT454071 SLC35E3 solute carrier family 35 member E3 2 2
MIRT456216 LIX1L limb and CNS expressed 1 like 2 6
MIRT456951 LRP10 LDL receptor related protein 10 2 2
MIRT458025 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT459999 RFT1 RFT1 homolog 2 2
MIRT460046 CDCP1 CUB domain containing protein 1 2 2
MIRT460982 STK17B serine/threonine kinase 17b 2 2
MIRT464405 URM1 ubiquitin related modifier 1 2 2
MIRT466256 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT466536 TBXA2R thromboxane A2 receptor 2 2
MIRT470922 PLD5 phospholipase D family member 5 2 8
MIRT472835 MTMR10 myotubularin related protein 10 2 6
MIRT473352 MEMO1 mediator of cell motility 1 2 2
MIRT475504 HSP90B1 heat shock protein 90 beta family member 1 2 2
MIRT478862 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT480898 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT482686 NXN nucleoredoxin 2 4
MIRT484128 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT486172 TLE3 transducin like enhancer of split 3 2 4
MIRT486539 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486588 ZNF619 zinc finger protein 619 2 2
MIRT495475 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT495536 TXNRD2 thioredoxin reductase 2 2 2
MIRT495566 UNC5C unc-5 netrin receptor C 2 2
MIRT495719 PADI1 peptidyl arginine deiminase 1 2 2
MIRT495890 CLOCK clock circadian regulator 2 2
MIRT495932 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496026 ZBED3 zinc finger BED-type containing 3 2 2
MIRT496216 PAX6 paired box 6 2 2
MIRT496349 VAMP1 vesicle associated membrane protein 1 2 2
MIRT496354 PPY pancreatic polypeptide 2 2
MIRT496400 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT496416 PARVB parvin beta 2 2
MIRT496458 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 2 2
MIRT496519 GINS2 GINS complex subunit 2 2 2
MIRT496562 SLC39A9 solute carrier family 39 member 9 2 2
MIRT498605 KRT8 keratin 8 2 2
MIRT503434 SLC25A45 solute carrier family 25 member 45 2 6
MIRT503573 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT503847 ATP13A4 ATPase 13A4 2 4
MIRT504247 LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2 4
MIRT505606 SLC35F1 solute carrier family 35 member F1 2 2
MIRT507749 CERS2 ceramide synthase 2 2 4
MIRT508411 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508508 RSRC1 arginine and serine rich coiled-coil 1 2 6
MIRT508944 AK4 adenylate kinase 4 2 4
MIRT509460 ZNF587 zinc finger protein 587 2 6
MIRT509862 ZNF641 zinc finger protein 641 2 4
MIRT511397 IKZF3 IKAROS family zinc finger 3 2 6
MIRT512517 BTBD19 BTB domain containing 19 2 2
MIRT513507 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 6
MIRT514155 TMEM145 transmembrane protein 145 2 4
MIRT514486 SLPI secretory leukocyte peptidase inhibitor 2 4
MIRT514521 SHISA9 shisa family member 9 2 2
MIRT514970 KLLN killin, p53-regulated DNA replication inhibitor 2 4
MIRT515030 IRAK4 interleukin 1 receptor associated kinase 4 2 6
MIRT515963 C9orf156 tRNA methyltransferase O 2 2
MIRT516092 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT517223 PRIM1 DNA primase subunit 1 2 4
MIRT517459 PEX26 peroxisomal biogenesis factor 26 2 4
MIRT517790 EFCAB11 EF-hand calcium binding domain 11 2 2
MIRT517979 DSCR3 DSCR3 arrestin fold containing 2 2
MIRT519458 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT519599 ZNF805 zinc finger protein 805 2 2
MIRT520339 UBXN2A UBX domain protein 2A 2 2
MIRT521345 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521571 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT523382 GSG2 histone H3 associated protein kinase 2 8
MIRT524106 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT524886 ARHGAP11A Rho GTPase activating protein 11A 2 4
MIRT528772 CD1D CD1d molecule 2 2
MIRT530665 TRIM56 tripartite motif containing 56 2 2
MIRT531107 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT531575 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT535173 PLEKHB2 pleckstrin homology domain containing B2 2 4
MIRT544168 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT550582 SLC2A5 solute carrier family 2 member 5 2 2
MIRT551039 GDE1 glycerophosphodiester phosphodiesterase 1 2 4
MIRT551295 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551339 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT552092 SLFN12L schlafen family member 12 like 2 6
MIRT555403 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT557087 HOXB3 homeobox B3 2 2
MIRT559388 ATP11C ATPase phospholipid transporting 11C 2 2
MIRT560305 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT561028 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT562460 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT562982 PARK7 Parkinsonism associated deglycase 2 2
MIRT563548 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT564412 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT569437 PCGF3 polycomb group ring finger 3 2 2
MIRT572097 EXOC8 exocyst complex component 8 2 2
MIRT575571 Cd99 CD99 antigen 2 2
MIRT575789 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT576975 Lmtk2 lemur tyrosine kinase 2 2 2
MIRT610864 ARSA arylsulfatase A 2 2
MIRT614061 NTPCR nucleoside-triphosphatase, cancer-related 2 2
MIRT614141 THAP1 THAP domain containing 1 2 6
MIRT615235 BROX BRO1 domain and CAAX motif containing 2 2
MIRT617429 ANP32E acidic nuclear phosphoprotein 32 family member E 2 4
MIRT618882 MBL2 mannose binding lectin 2 2 2
MIRT618984 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619196 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620323 AQP6 aquaporin 6 2 2
MIRT621960 STX7 syntaxin 7 2 2
MIRT622057 SSBP2 single stranded DNA binding protein 2 2 2
MIRT624930 FBXW2 F-box and WD repeat domain containing 2 2 2
MIRT624986 ZNF665 zinc finger protein 665 2 4
MIRT625463 ZNF681 zinc finger protein 681 2 4
MIRT625497 SMAD9 SMAD family member 9 2 2
MIRT625599 KLHL23 kelch like family member 23 2 2
MIRT625668 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT625888 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT626161 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626238 ZNF749 zinc finger protein 749 2 2
MIRT626631 SLC30A6 solute carrier family 30 member 6 2 2
MIRT626994 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627898 OLFML2A olfactomedin like 2A 2 2
MIRT627988 NDRG3 NDRG family member 3 2 2
MIRT628324 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT628549 ZNF701 zinc finger protein 701 2 2
MIRT629464 WIZ widely interspaced zinc finger motifs 2 2
MIRT630527 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT631487 KLHL21 kelch like family member 21 2 2
MIRT631957 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT632178 CCL22 C-C motif chemokine ligand 22 2 2
MIRT632282 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT632321 TMEM185B transmembrane protein 185B 2 2
MIRT632853 IGF1 insulin like growth factor 1 2 2
MIRT632862 HSPA2 heat shock protein family A (Hsp70) member 2 2 2
MIRT633322 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT633398 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633930 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT634785 CBFA2T2 CBFA2/RUNX1 translocation partner 2 2 2
MIRT634851 ABCF1 ATP binding cassette subfamily F member 1 2 2
MIRT636370 OGFRL1 opioid growth factor receptor like 1 2 2
MIRT637219 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT637690 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 2 2
MIRT639196 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT639599 CD3EAP CD3e molecule associated protein 2 2
MIRT639681 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT640669 ARSK arylsulfatase family member K 2 2
MIRT642377 ZNF581 zinc finger protein 581 2 2
MIRT642403 ZNF556 zinc finger protein 556 2 2
MIRT645079 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT646475 ZNF669 zinc finger protein 669 2 2
MIRT647325 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT647490 ZNF639 zinc finger protein 639 2 2
MIRT647989 PDE12 phosphodiesterase 12 2 2
MIRT648196 CENPN centromere protein N 2 2
MIRT649006 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT650457 ZNF141 zinc finger protein 141 2 2
MIRT650533 CCDC77 coiled-coil domain containing 77 2 2
MIRT650999 ZNF770 zinc finger protein 770 2 2
MIRT653832 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 4
MIRT655734 NRXN3 neurexin 3 2 2
MIRT657577 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT658610 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT658633 ENAH ENAH, actin regulator 2 2
MIRT659820 CASP16 caspase 16, pseudogene 2 2
MIRT661142 ZNF43 zinc finger protein 43 2 2
MIRT661201 MPPE1 metallophosphoesterase 1 2 2
MIRT661436 MANSC1 MANSC domain containing 1 2 2
MIRT661498 CHMP1B charged multivesicular body protein 1B 2 2
MIRT661682 ZNF623 zinc finger protein 623 2 2
MIRT661796 NLRC3 NLR family CARD domain containing 3 2 2
MIRT661808 NUP85 nucleoporin 85 2 2
MIRT661861 ZNF766 zinc finger protein 766 2 2
MIRT661889 EXOSC6 exosome component 6 2 2
MIRT662291 SLC29A4 solute carrier family 29 member 4 2 2
MIRT662515 ANGPT4 angiopoietin 4 2 2
MIRT662682 LRRC47 leucine rich repeat containing 47 2 2
MIRT662716 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT662834 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT662890 PCDHA6 protocadherin alpha 6 2 2
MIRT663134 ULBP3 UL16 binding protein 3 2 2
MIRT663710 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663869 MUC20 mucin 20, cell surface associated 2 2
MIRT664267 NMUR1 neuromedin U receptor 1 2 2
MIRT664510 POLR3K RNA polymerase III subunit K 2 2
MIRT664659 TRIM65 tripartite motif containing 65 2 2
MIRT664849 HUS1 HUS1 checkpoint clamp component 2 2
MIRT664944 CARD6 caspase recruitment domain family member 6 2 4
MIRT665348 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT665514 UTP15 UTP15, small subunit processome component 2 2
MIRT665648 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT665668 TRAF1 TNF receptor associated factor 1 2 2
MIRT665692 TNPO3 transportin 3 2 2
MIRT665741 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT665850 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT665940 TBC1D19 TBC1 domain family member 19 2 4
MIRT666005 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT666172 SNX27 sorting nexin family member 27 2 4
MIRT666373 SHOX short stature homeobox 2 2
MIRT667004 PDPN podoplanin 2 4
MIRT667185 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT667603 LIPC lipase C, hepatic type 2 2
MIRT667828 IRGQ immunity related GTPase Q 2 2
MIRT667862 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT668296 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 4
MIRT668463 FAM208A family with sequence similarity 208 member A 2 2
MIRT668580 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT669012 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669103 CDK19 cyclin dependent kinase 19 2 2
MIRT670073 ZNF783 zinc finger family member 783 2 2
MIRT670326 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670756 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670964 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT670985 MED17 mediator complex subunit 17 2 2
MIRT671195 ZNF891 zinc finger protein 891 2 2
MIRT672423 SLC10A6 solute carrier family 10 member 6 2 2
MIRT672495 YIPF4 Yip1 domain family member 4 2 2
MIRT672537 MGAM maltase-glucoamylase 2 2
MIRT672749 ZNF585B zinc finger protein 585B 2 4
MIRT673390 ZNF124 zinc finger protein 124 2 2
MIRT673452 ZNF583 zinc finger protein 583 2 2
MIRT673917 DCTN6 dynactin subunit 6 2 2
MIRT673952 ZNF500 zinc finger protein 500 2 2
MIRT674102 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674167 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674206 FUT2 fucosyltransferase 2 2 2
MIRT674452 PURB purine rich element binding protein B 2 4
MIRT674687 PLCE1 phospholipase C epsilon 1 2 2
MIRT674701 TMEM59 transmembrane protein 59 2 2
MIRT674800 NPR1 natriuretic peptide receptor 1 2 4
MIRT675247 MAK male germ cell associated kinase 2 2
MIRT676012 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676374 APTX aprataxin 2 2
MIRT676834 TNFSF15 TNF superfamily member 15 2 2
MIRT678193 CRCP CGRP receptor component 2 2
MIRT678293 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT679532 RAB36 RAB36, member RAS oncogene family 2 2
MIRT679669 RABAC1 Rab acceptor 1 2 2
MIRT679850 GPR75 G protein-coupled receptor 75 2 2
MIRT680533 PRIM2 DNA primase subunit 2 2 2
MIRT680563 ZNF584 zinc finger protein 584 2 2
MIRT680577 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT680849 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT680888 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT680940 EVC EvC ciliary complex subunit 1 2 2
MIRT680964 SLC15A1 solute carrier family 15 member 1 2 4
MIRT681017 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681065 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT681209 ZNF638 zinc finger protein 638 2 2
MIRT681291 RFC2 replication factor C subunit 2 2 2
MIRT681366 BRI3BP BRI3 binding protein 2 2
MIRT681517 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681549 ZNF738 zinc finger protein 738 2 2
MIRT681574 ABHD15 abhydrolase domain containing 15 2 2
MIRT681597 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT681806 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681912 SLC11A2 solute carrier family 11 member 2 2 2
MIRT681953 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682037 AGXT2 alanine--glyoxylate aminotransferase 2 2 4
MIRT682111 ITGA3 integrin subunit alpha 3 2 4
MIRT682190 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682247 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682394 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682554 EXOSC2 exosome component 2 2 2
MIRT682665 CASP8 caspase 8 2 2
MIRT683283 ZNF99 zinc finger protein 99 2 2
MIRT683359 SCARF1 scavenger receptor class F member 1 2 2
MIRT683453 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT683596 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT683661 ZNF695 zinc finger protein 695 2 2
MIRT683770 CPE carboxypeptidase E 2 2
MIRT683807 NOTO notochord homeobox 2 2
MIRT684462 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684525 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT684985 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685012 CXorf56 chromosome X open reading frame 56 2 2
MIRT685072 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685115 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685477 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT685831 SLC27A1 solute carrier family 27 member 1 2 2
MIRT686032 UMPS uridine monophosphate synthetase 2 2
MIRT686559 TPM3 tropomyosin 3 2 2
MIRT687287 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT687309 OTUD7B OTU deubiquitinase 7B 2 2
MIRT688085 GLUL glutamate-ammonia ligase 2 2
MIRT688168 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT688584 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT688601 CYCS cytochrome c, somatic 2 2
MIRT688921 C11orf84 chromosome 11 open reading frame 84 2 2
MIRT689285 C5AR2 complement component 5a receptor 2 2 2
MIRT689622 AKAP6 A-kinase anchoring protein 6 2 2
MIRT690051 C6orf141 chromosome 6 open reading frame 141 2 2
MIRT690224 C5orf45 MRN complex interacting protein 2 2
MIRT690272 CAMLG calcium modulating ligand 2 2
MIRT690331 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT690480 ZNF33A zinc finger protein 33A 2 2
MIRT690526 ZNF566 zinc finger protein 566 2 2
MIRT690581 MICA MHC class I polypeptide-related sequence A 2 2
MIRT690675 RPF2 ribosome production factor 2 homolog 2 2
MIRT690790 ZNF589 zinc finger protein 589 2 2
MIRT690873 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT691142 HJURP Holliday junction recognition protein 2 2
MIRT691158 APOL6 apolipoprotein L6 2 2
MIRT691288 CENPM centromere protein M 2 2
MIRT691435 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT691749 IKBKG inhibitor of nuclear factor kappa B kinase subunit gamma 2 2
MIRT691833 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT691885 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT691947 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT692047 PAK1IP1 PAK1 interacting protein 1 2 2
MIRT692668 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT692767 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT692859 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT693122 SCNM1 sodium channel modifier 1 2 2
MIRT693514 MOB3A MOB kinase activator 3A 2 2
MIRT693648 ACBD7 acyl-CoA binding domain containing 7 2 2
MIRT693688 MXRA7 matrix remodeling associated 7 2 2
MIRT694078 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT694163 SLC36A2 solute carrier family 36 member 2 2 2
MIRT694262 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT694506 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT694556 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT694639 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT694710 CD300LG CD300 molecule like family member g 2 2
MIRT694753 LLGL1 LLGL1, scribble cell polarity complex component 2 2
MIRT694896 ZNF417 zinc finger protein 417 2 2
MIRT695158 BTD biotinidase 2 2
MIRT695275 CD209 CD209 molecule 2 2
MIRT695434 TCF23 transcription factor 23 2 2
MIRT695817 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT696008 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696345 SLC35D2 solute carrier family 35 member D2 2 2
MIRT696368 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT696533 C3 complement C3 2 2
MIRT696779 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT697075 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT697498 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT697630 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT697931 TXNDC16 thioredoxin domain containing 16 2 2
MIRT697966 TSPYL1 TSPY like 1 2 2
MIRT698237 TMEM216 transmembrane protein 216 2 2
MIRT698643 TES testin LIM domain protein 2 2
MIRT698661 TERF2 telomeric repeat binding factor 2 2 2
MIRT698974 SPAST spastin 2 2
MIRT699047 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699193 SLX4IP SLX4 interacting protein 2 2
MIRT699586 SIKE1 suppressor of IKBKE 1 2 2
MIRT699759 SEPHS1 selenophosphate synthetase 1 2 2
MIRT700350 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT700402 RAB13 RAB13, member RAS oncogene family 2 2
MIRT700418 QDPR quinoid dihydropteridine reductase 2 2
MIRT700546 PTBP2 polypyrimidine tract binding protein 2 2 2
MIRT700774 PLA2G4A phospholipase A2 group IVA 2 2
MIRT700875 PER2 period circadian clock 2 2 2
MIRT700952 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT701077 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT701172 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT701479 NEK9 NIMA related kinase 9 2 2
MIRT701661 MYH9 myosin heavy chain 9 2 2
MIRT701779 MSL2 MSL complex subunit 2 2 2
MIRT702137 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT702494 KIAA1328 KIAA1328 2 2
MIRT703058 GTPBP10 GTP binding protein 10 2 2
MIRT703224 GOLGA3 golgin A3 2 2
MIRT703620 FBXO45 F-box protein 45 2 2
MIRT703657 FAM60A SIN3-HDAC complex associated factor 2 2
MIRT703765 FAM118A family with sequence similarity 118 member A 2 2
MIRT703832 EVI5 ecotropic viral integration site 5 2 2
MIRT703862 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT704664 CLCC1 chloride channel CLIC like 1 2 2
MIRT704812 CDC73 cell division cycle 73 2 2
MIRT705608 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT705625 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 2
MIRT705682 ANKRD40 ankyrin repeat domain 40 2 2
MIRT705813 AKNA AT-hook transcription factor 2 2
MIRT706238 SYT15 synaptotagmin 15 2 2
MIRT706567 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT709657 DFFB DNA fragmentation factor subunit beta 2 2
MIRT710609 ZNF555 zinc finger protein 555 2 2
MIRT711717 IREB2 iron responsive element binding protein 2 2 2
MIRT714122 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT715204 FKTN fukutin 2 2
MIRT718260 ZDHHC8 zinc finger DHHC-type containing 8 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4419b Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4419b Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4419b Cisplatin + Decitabine resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-mir-4419b Androstenedione+Anastrozole sensitive cell line (MCF-7)

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