pre-miRNA Information
pre-miRNA hsa-mir-548t   
Genomic Coordinates chr4: 173268160 - 173268233
Description Homo sapiens miR-548t stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548t-3p
Sequence 46| AAAAACCACAAUUACUUUUGCACCA |70
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 4 + 173268206 29233923 MiREDiBase
A-to-I 3 4 + 173268207 29233923 MiREDiBase
A-to-I 4 4 + 173268208 29233923 MiREDiBase
A-to-I 10 4 + 173268214 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs73872515 5 dbSNP
rs1426966747 6 dbSNP
rs1158401109 21 dbSNP
rs943938928 24 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF665   
Synonyms ZFP160L
Description zinc finger protein 665
Transcript NM_024733   
Expression
Putative miRNA Targets on ZNF665
3'UTR of ZNF665
(miRNA target sites are highlighted)
>ZNF665|NM_024733|3'UTR
   1 AAACCTTACAAAGGACGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGGGGATCACC
  81 TGAGGTCTCGAGTTCGAGACCAGGCTGGCCAACACGGTGAAACGCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGT
 161 GGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAG
 241 TGAGCGAGATCATGCCATTGCACTCCAGCCTGGGCAACAGGAGTGAAACTCCATCTCCAAAAAAAAAAAAAAAAAAAAAG
 321 TAACCTTACAAAGGAGTGCGGCCAGTTTTTCAGCCACAAATTCTTTCACAACATCAGAGAATTCATTCTTGAGACAATTC
 401 TTACAAATACAGTGACTGTGGCAAACTCCTGATGAGTTTAAGCATTAACAGACATCAGAGTTCAAATCCTGTGAATATAC
 481 TATGTATGACAGAAGCTTTATCCAGGTCTCAGAGCTCAATACGCATCAAAAGATACATCTTTGATGAAGTCACACAAACG
 561 TAACATGCATGCTGAGACTATTACTCCTGGACCACAACTGTAGGTGAGGATTCATAGGAAGAGTAGAACTCAGTCTCTAG
 641 TTTCCTCATAACCCTCTGATATTATATACTTCAGCATAATCAGAAGTCCAAATGTGTTAAAACTCATTACATGATACATA
 721 TCAAAGGTTGTAGGATGTTTGGAAATGGCCAATTACTTTCAGCTTATAAAATGTTTTGTTGAAGTATTTAAGATTTATTG
 801 AAAAGGCTACTATTTATAACTTCCAACCAGAACTTTGCAATGTGCTGATTTTATACATGATTATACGCCTAACATGGTGT
 881 TGTTCGGGAAAGAATCAAAGGATGGAAGGGCTCACTCACTTCATTAGGTGAGGATTATTTCTCTCCAAGCTCCTGAAGAA
 961 AAAAGACTCTGCCTTTTAAAATTAAATATAGTCTGAATTAGAGAGCACTTGGAAAGGGCAGAGGATGATGAACTATGATG
1041 TCACTCATCATCCTTATTGCACTGCAGGTGCCCTTCTTCTGACAGAAGAGCACTGTGGGTATGGGAAGAAATTCTCTACT
1121 GGCCGGGCACAGTGGCTCACGCCTGTAATGCCAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' accacguuuucAUUAACACCAAAAa 5'
                     |||   |||| || 
Target 5' gattatacgccTAA-CATGGTGTTg 3'
859 - 882 109.00 -6.20
2
miRNA  3' acCACGUUUUCAUUAACAC-CAAAaa 5'
            |||  ||| |  |  || ||||  
Target 5' ctGTGGCAAACTCCTGATGAGTTTaa 3'
416 - 441 107.00 -7.40
3
miRNA  3' accAC-GUUUUCAU-UAACACCAAAAa 5'
             || ||:||| : | ||||| | | 
Target 5' ttcTGACAGAAGAGCACTGTGGGTATg 3'
1077 - 1103 106.00 -9.93
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30162044 17 COSMIC
COSN13826472 20 COSMIC
COSN30496225 23 COSMIC
COSN13826469 24 COSMIC
COSN31625600 34 COSMIC
COSN30122221 35 COSMIC
COSN30169704 36 COSMIC
COSN31534032 38 COSMIC
COSN18742371 69 COSMIC
COSN30477104 95 COSMIC
COSN31593097 113 COSMIC
COSN13826462 115 COSMIC
COSN18776711 299 COSMIC
COSN20844791 339 COSMIC
COSN24744345 435 COSMIC
COSN25349964 720 COSMIC
COSN26724973 779 COSMIC
COSN26804165 991 COSMIC
COSN32057012 1023 COSMIC
COSN7449103 1140 COSMIC
COSN20864462 1189 COSMIC
COSN19408741 1350 COSMIC
COSN29573333 1402 COSMIC
COSN25509035 1430 COSMIC
COSN8975654 1716 COSMIC
COSN28897973 1822 COSMIC
COSN16060695 1871 COSMIC
COSN5761839 1994 COSMIC
rs1133146 1046 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775879844 5 dbSNP
rs1020110499 9 dbSNP
rs772509712 10 dbSNP
rs746229652 13 dbSNP
rs1230012080 16 dbSNP
rs548473021 16 dbSNP
rs1051450672 17 dbSNP
rs771542547 19 dbSNP
rs749799035 20 dbSNP
rs138817165 21 dbSNP
rs144934242 22 dbSNP
rs751163511 23 dbSNP
rs550775146 24 dbSNP
rs1271154011 25 dbSNP
rs1198025272 32 dbSNP
rs1042794479 33 dbSNP
rs758115625 35 dbSNP
rs532688642 36 dbSNP
rs1378878328 40 dbSNP
rs765068450 45 dbSNP
rs1450671103 47 dbSNP
rs1360461883 50 dbSNP
rs1249774654 54 dbSNP
rs565270654 58 dbSNP
rs915708751 63 dbSNP
rs1198179036 64 dbSNP
rs547064598 64 dbSNP
rs528499519 68 dbSNP
rs4803054 69 dbSNP
rs919648598 70 dbSNP
rs192743148 72 dbSNP
rs1322993041 73 dbSNP
rs928538024 74 dbSNP
rs1299979516 76 dbSNP
rs1429544145 79 dbSNP
rs1207576681 86 dbSNP
rs1283575359 88 dbSNP
rs1329160250 89 dbSNP
rs974161961 90 dbSNP
rs958368293 95 dbSNP
rs749065447 96 dbSNP
rs1453439321 97 dbSNP
rs1200268414 99 dbSNP
rs1411446326 100 dbSNP
rs951347588 105 dbSNP
rs1161740032 109 dbSNP
rs1457829314 114 dbSNP
rs372038384 115 dbSNP
rs190045639 116 dbSNP
rs1303258510 117 dbSNP
rs1349437919 118 dbSNP
rs1363314292 118 dbSNP
rs1226195059 119 dbSNP
rs1320068069 120 dbSNP
rs1308875403 123 dbSNP
rs755756449 124 dbSNP
rs1010038732 126 dbSNP
rs1243952467 127 dbSNP
rs957445121 131 dbSNP
rs184566348 132 dbSNP
rs964257246 133 dbSNP
rs1018887210 134 dbSNP
rs1304569064 136 dbSNP
rs1439092443 142 dbSNP
rs1332399400 154 dbSNP
rs146632398 156 dbSNP
rs543892284 157 dbSNP
rs1370632492 158 dbSNP
rs1423634494 161 dbSNP
rs1163160768 170 dbSNP
rs900524537 171 dbSNP
rs1040776442 173 dbSNP
rs1009139940 185 dbSNP
rs755573737 190 dbSNP
rs1042848694 191 dbSNP
rs947098126 197 dbSNP
rs1187536526 203 dbSNP
rs1169992460 209 dbSNP
rs1373644006 212 dbSNP
rs1432730942 213 dbSNP
rs10427112 214 dbSNP
rs558231972 229 dbSNP
rs549945629 230 dbSNP
rs1273993654 234 dbSNP
rs1340192103 238 dbSNP
rs898249930 239 dbSNP
rs376363633 244 dbSNP
rs572810529 245 dbSNP
rs937066243 246 dbSNP
rs927017194 253 dbSNP
rs981095590 262 dbSNP
rs1248642367 271 dbSNP
rs7260409 280 dbSNP
rs1445763913 295 dbSNP
rs1297222283 296 dbSNP
rs1229391248 298 dbSNP
rs1328326155 299 dbSNP
rs1491476170 299 dbSNP
rs949956329 299 dbSNP
rs1491122280 300 dbSNP
rs982621716 300 dbSNP
rs1299326482 308 dbSNP
rs1465234133 312 dbSNP
rs1386236785 318 dbSNP
rs1384795389 319 dbSNP
rs1208365607 320 dbSNP
rs1208621383 320 dbSNP
rs1216356828 320 dbSNP
rs1224066614 320 dbSNP
rs1228442407 320 dbSNP
rs1265375079 320 dbSNP
rs1296402278 320 dbSNP
rs1311758846 320 dbSNP
rs1362980282 320 dbSNP
rs1432222437 320 dbSNP
rs1453256892 320 dbSNP
rs35735454 320 dbSNP
rs764331903 320 dbSNP
rs774279031 320 dbSNP
rs775717687 320 dbSNP
rs146187673 322 dbSNP
rs1173579816 332 dbSNP
rs1407987550 338 dbSNP
rs951400212 339 dbSNP
rs919897949 340 dbSNP
rs12985467 349 dbSNP
rs12986080 355 dbSNP
rs1367072258 356 dbSNP
rs1217669956 359 dbSNP
rs192315888 367 dbSNP
rs1368457636 370 dbSNP
rs1228104110 374 dbSNP
rs1018356793 387 dbSNP
rs1033240101 388 dbSNP
rs1383506537 395 dbSNP
rs201806685 401 dbSNP
rs965147584 404 dbSNP
rs1449669507 410 dbSNP
rs12972121 411 dbSNP
rs1196689922 412 dbSNP
rs1430909720 414 dbSNP
rs762010738 422 dbSNP
rs1158060974 432 dbSNP
rs1409567744 446 dbSNP
rs1196157629 447 dbSNP
rs776759119 448 dbSNP
rs1402361791 453 dbSNP
rs1318959696 473 dbSNP
rs955492230 478 dbSNP
rs886708615 479 dbSNP
rs1026498363 480 dbSNP
rs768693212 482 dbSNP
rs1305058096 486 dbSNP
rs1346310119 493 dbSNP
rs902866361 494 dbSNP
rs1286830826 496 dbSNP
rs1225357450 497 dbSNP
rs1224794997 499 dbSNP
rs899356423 500 dbSNP
rs1055701243 508 dbSNP
rs937141798 511 dbSNP
rs1219550050 515 dbSNP
rs1011224460 520 dbSNP
rs6509729 522 dbSNP
rs1206266436 533 dbSNP
rs12971840 535 dbSNP
rs1471064578 536 dbSNP
rs938519568 543 dbSNP
rs6509728 559 dbSNP
rs1046978096 565 dbSNP
rs1409412005 575 dbSNP
rs12971799 580 dbSNP
rs1337785903 581 dbSNP
rs543641475 586 dbSNP
rs1443321076 591 dbSNP
rs1331756134 597 dbSNP
rs151291979 598 dbSNP
rs1283918296 599 dbSNP
rs777649455 618 dbSNP
rs1248889319 630 dbSNP
rs935913478 638 dbSNP
rs925842122 640 dbSNP
rs1359596278 644 dbSNP
rs1203966000 647 dbSNP
rs974947063 648 dbSNP
rs867568395 652 dbSNP
rs1296106532 654 dbSNP
rs1439220092 656 dbSNP
rs1182190980 661 dbSNP
rs964825654 668 dbSNP
rs1018959015 669 dbSNP
rs987444082 673 dbSNP
rs950750608 682 dbSNP
rs1026257408 683 dbSNP
rs995140479 685 dbSNP
rs755885420 686 dbSNP
rs1033861863 694 dbSNP
rs1398197565 698 dbSNP
rs1333920926 700 dbSNP
rs576346889 713 dbSNP
rs73057857 722 dbSNP
rs1365147464 734 dbSNP
rs544868610 737 dbSNP
rs1429364462 742 dbSNP
rs978244701 752 dbSNP
rs1267915718 757 dbSNP
rs1471877788 764 dbSNP
rs1045536420 765 dbSNP
rs1341028693 766 dbSNP
rs1196072694 767 dbSNP
rs1013994210 770 dbSNP
rs1459841528 778 dbSNP
rs1205364883 782 dbSNP
rs891505631 790 dbSNP
rs1183372596 793 dbSNP
rs968315231 794 dbSNP
rs117069309 796 dbSNP
rs935940063 801 dbSNP
rs1404326269 805 dbSNP
rs1471139709 807 dbSNP
rs1200082391 810 dbSNP
rs1337832811 812 dbSNP
rs1388477304 817 dbSNP
rs1381031972 825 dbSNP
rs1315593782 831 dbSNP
rs894099988 837 dbSNP
rs925821885 840 dbSNP
rs1227658612 841 dbSNP
rs545148675 848 dbSNP
rs34751425 866 dbSNP
rs1225056335 867 dbSNP
rs906947896 867 dbSNP
rs1464384949 870 dbSNP
rs1046902772 871 dbSNP
rs1263918374 873 dbSNP
rs1198292829 877 dbSNP
rs367717505 877 dbSNP
rs1327022689 885 dbSNP
rs1481550974 886 dbSNP
rs1177523099 892 dbSNP
rs187877009 913 dbSNP
rs911715784 917 dbSNP
rs539960910 918 dbSNP
rs1452231644 919 dbSNP
rs987542375 923 dbSNP
rs898439732 930 dbSNP
rs1382248273 932 dbSNP
rs1442664568 946 dbSNP
rs1337305957 951 dbSNP
rs140353084 953 dbSNP
rs1406460180 955 dbSNP
rs1133145 961 dbSNP
rs1406221261 967 dbSNP
rs973779362 970 dbSNP
rs987303636 971 dbSNP
rs1262380063 973 dbSNP
rs769060927 986 dbSNP
rs1209259894 988 dbSNP
rs1266873265 989 dbSNP
rs1490901615 993 dbSNP
rs1200475412 994 dbSNP
rs1251505436 997 dbSNP
rs934094741 1006 dbSNP
rs963666194 1006 dbSNP
rs1364819924 1017 dbSNP
rs542548575 1035 dbSNP
rs575542318 1036 dbSNP
rs1162370852 1038 dbSNP
rs1034323993 1044 dbSNP
rs1133146 1046 dbSNP
rs1411881954 1052 dbSNP
rs1303423802 1053 dbSNP
rs970908168 1056 dbSNP
rs568635891 1062 dbSNP
rs538798098 1064 dbSNP
rs1308901092 1068 dbSNP
rs1336210521 1070 dbSNP
rs1245244593 1072 dbSNP
rs1289650652 1076 dbSNP
rs1025145295 1085 dbSNP
rs758872511 1107 dbSNP
rs571483703 1116 dbSNP
rs1014046380 1120 dbSNP
rs553477567 1124 dbSNP
rs1052788776 1125 dbSNP
rs1179249397 1126 dbSNP
rs550106742 1127 dbSNP
rs1423729199 1128 dbSNP
rs373886917 1136 dbSNP
rs1039389314 1138 dbSNP
rs756568762 1140 dbSNP
rs567540022 1141 dbSNP
rs991062608 1145 dbSNP
rs943284565 1148 dbSNP
rs1236068883 1149 dbSNP
rs1187158933 1150 dbSNP
rs1460157490 1154 dbSNP
rs1299669213 1157 dbSNP
rs958626083 1160 dbSNP
rs1443247900 1161 dbSNP
rs1245142586 1162 dbSNP
rs1312776098 1165 dbSNP
rs1206915808 1173 dbSNP
rs911768111 1177 dbSNP
rs1051541004 1183 dbSNP
rs1196412250 1184 dbSNP
rs147575004 1188 dbSNP
rs919304979 1190 dbSNP
rs973448076 1192 dbSNP
rs1352633004 1193 dbSNP
rs1282180154 1200 dbSNP
rs963680393 1201 dbSNP
rs1243742574 1214 dbSNP
rs907000267 1218 dbSNP
rs1338221452 1219 dbSNP
rs1432345509 1221 dbSNP
rs1245458158 1224 dbSNP
rs11668679 1227 dbSNP
rs1319617741 1228 dbSNP
rs570721348 1229 dbSNP
rs1418260218 1232 dbSNP
rs981469161 1240 dbSNP
rs970960239 1247 dbSNP
rs1373319157 1254 dbSNP
rs1163068152 1259 dbSNP
rs1445553393 1261 dbSNP
rs1025155133 1262 dbSNP
rs1009698576 1263 dbSNP
rs1453368737 1266 dbSNP
rs1288349733 1268 dbSNP
rs1186901537 1270 dbSNP
rs12977280 1271 dbSNP
rs1006780184 1274 dbSNP
rs1339735014 1276 dbSNP
rs1242752123 1295 dbSNP
rs1216459377 1301 dbSNP
rs1448691582 1303 dbSNP
rs192593712 1305 dbSNP
rs889690097 1308 dbSNP
rs1209028884 1310 dbSNP
rs1359883837 1314 dbSNP
rs1316785545 1316 dbSNP
rs1225704741 1317 dbSNP
rs1363884652 1323 dbSNP
rs999932357 1324 dbSNP
rs904213512 1326 dbSNP
rs1017270235 1327 dbSNP
rs1173981308 1328 dbSNP
rs139803535 1332 dbSNP
rs890340116 1334 dbSNP
rs1470233686 1336 dbSNP
rs1042454842 1341 dbSNP
rs1323397081 1342 dbSNP
rs559547709 1350 dbSNP
rs991380895 1351 dbSNP
rs1403411828 1357 dbSNP
rs187675394 1359 dbSNP
rs1167001916 1360 dbSNP
rs1324782954 1368 dbSNP
rs1282705391 1372 dbSNP
rs897928297 1379 dbSNP
rs1392603283 1386 dbSNP
rs528230014 1388 dbSNP
rs1038220353 1389 dbSNP
rs981106692 1390 dbSNP
rs1420443615 1391 dbSNP
rs1025351881 1394 dbSNP
rs993856371 1395 dbSNP
rs1176432030 1402 dbSNP
rs1405630360 1404 dbSNP
rs942124527 1406 dbSNP
rs1188380813 1408 dbSNP
rs1159923775 1410 dbSNP
rs1477044736 1411 dbSNP
rs1244979645 1416 dbSNP
rs962875699 1418 dbSNP
rs757922937 1422 dbSNP
rs1007119311 1426 dbSNP
rs1346407247 1429 dbSNP
rs560719597 1432 dbSNP
rs980762291 1433 dbSNP
rs372398522 1437 dbSNP
rs1376158711 1438 dbSNP
rs762064199 1439 dbSNP
rs1224882523 1451 dbSNP
rs1286081485 1458 dbSNP
rs1358155265 1463 dbSNP
rs1051000947 1464 dbSNP
rs752352474 1466 dbSNP
rs998196419 1471 dbSNP
rs1215816739 1472 dbSNP
rs1231031584 1476 dbSNP
rs1364866622 1488 dbSNP
rs918148302 1494 dbSNP
rs1042507067 1533 dbSNP
rs1384657831 1537 dbSNP
rs1442803655 1546 dbSNP
rs1165558725 1552 dbSNP
rs988320124 1563 dbSNP
rs1409672882 1568 dbSNP
rs144589625 1570 dbSNP
rs1347824921 1578 dbSNP
rs1055336595 1579 dbSNP
rs1306596203 1582 dbSNP
rs1429457155 1584 dbSNP
rs1355343195 1585 dbSNP
rs1172802305 1587 dbSNP
rs1307019466 1601 dbSNP
rs1316541119 1601 dbSNP
rs1356609181 1601 dbSNP
rs146693184 1601 dbSNP
rs556086994 1602 dbSNP
rs1270600084 1607 dbSNP
rs1439389704 1608 dbSNP
rs1199076221 1609 dbSNP
rs1412897706 1614 dbSNP
rs1459926491 1626 dbSNP
rs1032490729 1631 dbSNP
rs978960353 1634 dbSNP
rs1369184118 1635 dbSNP
rs928226666 1645 dbSNP
rs1166410813 1649 dbSNP
rs968491987 1656 dbSNP
rs1198658780 1659 dbSNP
rs971057470 1660 dbSNP
rs1404459030 1664 dbSNP
rs1480743480 1665 dbSNP
rs1017698301 1668 dbSNP
rs1338116297 1671 dbSNP
rs1340607087 1675 dbSNP
rs1007142827 1685 dbSNP
rs1268008321 1701 dbSNP
rs972797166 1715 dbSNP
rs962518050 1729 dbSNP
rs1017095124 1731 dbSNP
rs890392461 1733 dbSNP
rs1480147514 1739 dbSNP
rs183076648 1740 dbSNP
rs993362616 1743 dbSNP
rs1244003481 1761 dbSNP
rs1029602199 1768 dbSNP
rs563542431 1771 dbSNP
rs1309978234 1779 dbSNP
rs897691433 1780 dbSNP
rs1427710202 1783 dbSNP
rs559432548 1789 dbSNP
rs1223549741 1793 dbSNP
rs942115788 1802 dbSNP
rs1286937228 1803 dbSNP
rs902415942 1823 dbSNP
rs540646645 1824 dbSNP
rs1400285959 1825 dbSNP
rs764332142 1829 dbSNP
rs1343450674 1833 dbSNP
rs191224558 1835 dbSNP
rs893924733 1837 dbSNP
rs1349887269 1847 dbSNP
rs1374496094 1852 dbSNP
rs78350936 1856 dbSNP
rs375017838 1857 dbSNP
rs935568512 1858 dbSNP
rs1199035839 1867 dbSNP
rs925480199 1870 dbSNP
rs1481602379 1872 dbSNP
rs979591981 1874 dbSNP
rs574029755 1876 dbSNP
rs929589518 1877 dbSNP
rs1452334937 1880 dbSNP
rs1017332277 1881 dbSNP
rs369885604 1885 dbSNP
rs941018990 1893 dbSNP
rs954407210 1896 dbSNP
rs1156848934 1900 dbSNP
rs1343279725 1902 dbSNP
rs1388237826 1916 dbSNP
rs1301725059 1923 dbSNP
rs1418341362 1928 dbSNP
rs1250940154 1931 dbSNP
rs1029935974 1936 dbSNP
rs1281332306 1937 dbSNP
rs1354555686 1942 dbSNP
rs1221887612 1950 dbSNP
rs1482089224 1955 dbSNP
rs1490907082 1957 dbSNP
rs909642627 1960 dbSNP
rs111333211 1968 dbSNP
rs1417826297 1975 dbSNP
rs953870402 1977 dbSNP
rs1203767601 1986 dbSNP
rs1439721239 1995 dbSNP
rs1162392543 2004 dbSNP
rs569736116 2006 dbSNP
rs1363256508 2017 dbSNP
rs1266846836 2018 dbSNP
rs1238934133 2026 dbSNP
rs1029528865 2027 dbSNP
rs1317941752 2028 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' accacguuUUCAUUAACACCaaaaa 5'
                  |||||:   |||     
Target 5' agccucccAAGUAG--CUGGg---- 3'
22 - 40
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000600412.1 | 3UTR | UUUUAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000600412.1 | 3UTR | UAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000600412.1 | 3UTR | UUAGCGAUUCUCCUGCCUCAGCCUCCCAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000600412.1 | 3UTR | UUUAGCGAUUCUCCUGCCUCAGCCUCCCAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
168 hsa-miR-548t-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059365 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT072839 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 6
MIRT076945 PCGF2 polycomb group ring finger 2 2 6
MIRT083941 TFAP2C transcription factor AP-2 gamma 2 2
MIRT085401 ETS2 ETS proto-oncogene 2, transcription factor 2 2
MIRT109790 KLHL15 kelch like family member 15 2 2
MIRT114046 AKAP11 A-kinase anchoring protein 11 2 10
MIRT130165 TXNIP thioredoxin interacting protein 2 6
MIRT150013 MIDN midnolin 2 2
MIRT181258 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT205594 NCL nucleolin 2 2
MIRT222253 ACTB actin beta 2 4
MIRT245653 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT250947 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT252497 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT271990 ARF1 ADP ribosylation factor 1 2 4
MIRT280804 RNF11 ring finger protein 11 2 2
MIRT293803 FEM1A fem-1 homolog A 2 2
MIRT318231 RREB1 ras responsive element binding protein 1 2 2
MIRT341455 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT347413 CEBPG CCAAT/enhancer binding protein gamma 2 4
MIRT351860 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT357983 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT377094 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT407303 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT441564 LMOD3 leiomodin 3 2 2
MIRT442364 ZC3H12C zinc finger CCCH-type containing 12C 2 2
MIRT443228 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT443404 HMX3 H6 family homeobox 3 2 2
MIRT446055 NR5A2 nuclear receptor subfamily 5 group A member 2 2 2
MIRT448277 ZNF652 zinc finger protein 652 2 2
MIRT450822 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT453016 CCDC115 coiled-coil domain containing 115 2 17
MIRT454463 PPP2R2B protein phosphatase 2 regulatory subunit Bbeta 2 2
MIRT456360 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 2 2
MIRT460007 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT463154 ZNF385A zinc finger protein 385A 2 6
MIRT463766 YPEL2 yippee like 2 2 2
MIRT468310 SFT2D2 SFT2 domain containing 2 2 2
MIRT470668 POLR2D RNA polymerase II subunit D 2 4
MIRT478517 CTTN cortactin 2 2
MIRT480507 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT484718 INHBA inhibin beta A subunit 2 12
MIRT485494 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT487302 SLC38A9 solute carrier family 38 member 9 2 2
MIRT487771 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491876 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494304 CEP120 centrosomal protein 120 2 2
MIRT495396 TRIM24 tripartite motif containing 24 2 2
MIRT495646 CDK1 cyclin dependent kinase 1 2 2
MIRT496665 TMEM237 transmembrane protein 237 2 2
MIRT496837 ZNF460 zinc finger protein 460 2 2
MIRT498638 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT503928 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT506063 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT506582 MIER3 MIER family member 3 2 4
MIRT506606 MAT2A methionine adenosyltransferase 2A 2 4
MIRT506844 KIF23 kinesin family member 23 2 6
MIRT508536 RPP14 ribonuclease P/MRP subunit p14 2 4
MIRT509669 ZNF354B zinc finger protein 354B 2 10
MIRT511170 MBNL3 muscleblind like splicing regulator 3 2 6
MIRT512147 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT512831 ID4 inhibitor of DNA binding 4, HLH protein 2 6
MIRT514558 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515856 AJAP1 adherens junctions associated protein 1 2 4
MIRT521848 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT525364 SYNM synemin 2 2
MIRT527120 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT527271 FBLN2 fibulin 2 2 2
MIRT527439 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT527658 CD300E CD300e molecule 2 2
MIRT528334 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529033 EXOC8 exocyst complex component 8 2 2
MIRT529321 PDE5A phosphodiesterase 5A 2 2
MIRT529677 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529846 SMTN smoothelin 2 2
MIRT530385 ZNF431 zinc finger protein 431 2 2
MIRT530913 GPR85 G protein-coupled receptor 85 2 2
MIRT531794 KDR kinase insert domain receptor 2 2
MIRT532246 KLF2 Kruppel like factor 2 2 4
MIRT532658 CBX7 chromobox 7 2 2
MIRT533630 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT534811 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT534975 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536588 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT536779 HNRNPD heterogeneous nuclear ribonucleoprotein D 2 2
MIRT538764 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539294 ANGEL2 angel homolog 2 2 2
MIRT539621 SHISA9 shisa family member 9 2 2
MIRT539651 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540347 OPHN1 oligophrenin 1 2 2
MIRT540413 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541396 CDC27 cell division cycle 27 2 2
MIRT542916 HSBP1 heat shock factor binding protein 1 2 2
MIRT544710 EIF5A eukaryotic translation initiation factor 5A 2 4
MIRT544998 MFF mitochondrial fission factor 2 4
MIRT553289 TSPAN3 tetraspanin 3 2 2
MIRT553455 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT553782 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT554656 ROBO1 roundabout guidance receptor 1 2 2
MIRT555104 PURB purine rich element binding protein B 2 2
MIRT557235 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT560861 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561545 SON SON DNA binding protein 2 2
MIRT561554 SLMO2 PRELI domain containing 3B 2 2
MIRT563764 ZNF678 zinc finger protein 678 2 2
MIRT565653 SIX4 SIX homeobox 4 2 2
MIRT568080 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568759 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569078 CADM2 cell adhesion molecule 2 2 2
MIRT569509 THYN1 thymocyte nuclear protein 1 2 2
MIRT571268 CDKN2AIP CDKN2A interacting protein 2 2
MIRT571809 PHF19 PHD finger protein 19 2 2
MIRT572554 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT573782 SLC24A4 solute carrier family 24 member 4 2 4
MIRT576441 Ccdc115 coiled-coil domain containing 115 2 10
MIRT576712 Slc30a3 solute carrier family 30 (zinc transporter), member 3 2 3
MIRT608377 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608484 NKTR natural killer cell triggering receptor 2 6
MIRT610186 FAM49A family with sequence similarity 49 member A 2 2
MIRT611631 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT613534 TRA2B transformer 2 beta homolog 2 2
MIRT616221 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT622370 SALL1 spalt like transcription factor 1 2 2
MIRT624371 CDK12 cyclin dependent kinase 12 2 2
MIRT624995 ZNF665 zinc finger protein 665 2 4
MIRT626875 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627737 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT628490 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT633647 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 4
MIRT634028 SLC30A3 solute carrier family 30 member 3 2 3
MIRT635923 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638287 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT641959 RNF115 ring finger protein 115 2 2
MIRT643573 CTNNA3 catenin alpha 3 2 2
MIRT645180 NOL9 nucleolar protein 9 2 4
MIRT647497 ZNF639 zinc finger protein 639 2 2
MIRT647682 PCK1 phosphoenolpyruvate carboxykinase 1 2 2
MIRT648422 MYOZ3 myozenin 3 2 2
MIRT650113 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT651076 ZNF518B zinc finger protein 518B 2 4
MIRT651415 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT651456 XKR4 XK related 4 2 2
MIRT653619 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653637 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654896 POU2F1 POU class 2 homeobox 1 2 2
MIRT656483 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT658016 GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit 2 2
MIRT658041 FZD10 frizzled class receptor 10 2 2
MIRT660093 BTBD3 BTB domain containing 3 2 2
MIRT663923 MAGEF1 MAGE family member F1 2 2
MIRT665882 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT669051 CEP128 centrosomal protein 128 2 2
MIRT669711 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT686812 SNX2 sorting nexin 2 2 4
MIRT689883 SOD2 superoxide dismutase 2 2 2
MIRT693274 GLRX2 glutaredoxin 2 2 4
MIRT697056 BCAR1 BCAR1, Cas family scaffolding protein 2 2
MIRT703297 GID4 GID complex subunit 4 homolog 2 2
MIRT704087 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT707719 CDC6 cell division cycle 6 2 2
MIRT708136 GK5 glycerol kinase 5 (putative) 2 2
MIRT709212 KLHL30 kelch like family member 30 2 2
MIRT710062 RWDD2A RWD domain containing 2A 2 2
MIRT712770 POU6F2 POU class 6 homeobox 2 2 2
MIRT715073 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715387 TADA3 transcriptional adaptor 3 2 2
MIRT717712 NCKAP1 NCK associated protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548t Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-548t Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-548t Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-548t Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-548t Vincristine 5978 approved sensitive cell line (W1)
hsa-miR-548t-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-548t-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-548t-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)

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