pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol PAK4   
Synonyms -
Description p21 (RAC1) activated kinase 4
Transcript NM_001014831   
Other Transcripts NM_001014832 , NM_001014834 , NM_001014835 , NM_005884   
Expression
Putative miRNA Targets on PAK4
3'UTR of PAK4
(miRNA target sites are highlighted)
>PAK4|NM_001014831|3'UTR
   1 GGCCCAGCGCCCTTCCCCTCAACCAAAGAGCCCCCCGGGTCACCCCCGCCCCACTGAGGCCAGTAGGGGGCCAGGCCTCC
  81 CACTCCTCCCAGCCCGGGAGATGCTCCGCGTGGCACCACCCTCCTTGCTGGGGGTAGATGAGACCCTACTACTGAACTCC
 161 AGTTTTGATCTCGTGACTTTTAGAAAAACACAGGGACTCGTGGGAGCAAGCGAGGCTCCCAGGACCCCCACCCTCTGGGA
 241 CAGGCCCTCCCCCATGTTCTTCTGTCTCCAGGAAGGGCAGCGGCCCTCCCATCACTGGAAGTCTGCAGTGGGGGTCGCTG
 321 GGGGTGGAGAGAACACTAAGAGGTGAACATGTATGAGTGTGTGCACGCGTGTGAGTGTGCATGTGTGTGTGTGCAAAGGT
 401 CCAGCCACCCCGTCCTCCAGCCTGCAAGGGGTGTCTGGCGCCTTGCCTGACACCCAGCCCCCTCTCCCCCTGAGCCATTG
 481 TGGGGGTCGATCATGAATGTCCGAAGAGTGGCCTTTTCCCGTAGCCCTGCGCCCCCTTTCTGTGGCTGGATGGGGAGACA
 561 GGTCAGGGCCCCCCACCCTCTCCAGCCCCTGCAGCAAATGACTACTGCACCTGGACAGCCTCCTCTTTTCTAGAAGTCTA
 641 TTTATATTGTCATTTTATAACACTCTAGCCCCTGCCCTTATTGGGGGACAGATGGTCCCTGTCCTGCGGGGTGGCCCTGG
 721 CAGAACCACTGCCTGAAGAACCAGGTTCCTGCCCGGTCAGCGCAGCCCCAGCCCGCCCACCCCTGCCTCGAGTTAGTTTT
 801 ACAATTAAAACATTGTCTTGTTTTGTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agUGUCAACGGUCGACUCUaau 5'
            :| |  | :|| |||||   
Target 5' ttGCTGGGGGTAGATGAGAccc 3'
125 - 146 112.00 -10.02
2
miRNA  3' agugucaacGGUCGACUC--UAAu 5'
                   ||  |||||  ||| 
Target 5' gccccctctCCCCCTGAGCCATTg 3'
457 - 480 109.00 -8.30
3
miRNA  3' aguGUCA--ACGGUCG---ACUCUAau 5'
             || |  | |||||    |||||  
Target 5' tccCACTCCTCCCAGCCCGGGAGATgc 3'
78 - 104 105.00 -13.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20782498 7 COSMIC
COSN31481891 13 COSMIC
COSN30146112 21 COSMIC
COSN30153314 21 COSMIC
COSN31482616 21 COSMIC
COSN30534315 54 COSMIC
COSN30153142 57 COSMIC
COSN30543953 107 COSMIC
COSN26987840 109 COSMIC
COSN28718202 181 COSMIC
COSN15019840 368 COSMIC
COSN20115785 394 COSMIC
COSN19554793 398 COSMIC
COSN28656327 424 COSMIC
COSN16845700 480 COSMIC
COSN26636577 486 COSMIC
COSN31596007 501 COSMIC
COSN20093599 531 COSMIC
COSN31596474 531 COSMIC
COSN15808771 605 COSMIC
COSN31539794 755 COSMIC
COSN22372536 1043 COSMIC
COSN21365336 1601 COSMIC
COSN9357152 1741 COSMIC
COSN18759938 1884 COSMIC
COSN21896621 1933 COSMIC
COSN15871145 1983 COSMIC
COSN14463642 2237 COSMIC
COSN16075757 2314 COSMIC
COSN20801776 2560 COSMIC
COSN17841743 2585 COSMIC
COSN1215450 2734 COSMIC
COSN7126656 2957 COSMIC
COSN15265206 2962 COSMIC
COSN29293393 3010 COSMIC
COSN21763519 3169 COSMIC
COSN1768009 3263 COSMIC
COSN29250091 3666 COSMIC
COSN14874056 3729 COSMIC
COSN6668621 3861 COSMIC
COSN21390004 3877 COSMIC
COSN29335285 4220 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775689254 2 dbSNP
rs763288708 5 dbSNP
rs955292571 7 dbSNP
rs371711789 9 dbSNP
rs1390490815 10 dbSNP
rs774636800 13 dbSNP
rs1333750304 14 dbSNP
rs761914143 16 dbSNP
rs943433847 17 dbSNP
rs1292396979 19 dbSNP
rs1450272969 26 dbSNP
rs773498933 31 dbSNP
rs767574807 32 dbSNP
rs750337887 33 dbSNP
rs755890770 35 dbSNP
rs376520116 37 dbSNP
rs759197317 37 dbSNP
rs766236135 38 dbSNP
rs866108002 42 dbSNP
rs1012246574 43 dbSNP
rs753563139 45 dbSNP
rs921414646 46 dbSNP
rs754729427 48 dbSNP
rs778470823 49 dbSNP
rs1217004787 51 dbSNP
rs535863655 59 dbSNP
rs1487352453 64 dbSNP
rs920694233 70 dbSNP
rs936865698 71 dbSNP
rs1414567722 72 dbSNP
rs1054015107 78 dbSNP
rs930632358 83 dbSNP
rs1263792220 85 dbSNP
rs1168149811 89 dbSNP
rs1047768193 96 dbSNP
rs113335516 97 dbSNP
rs950314122 99 dbSNP
rs945690987 104 dbSNP
rs1236263563 105 dbSNP
rs576692321 108 dbSNP
rs186511166 110 dbSNP
rs1347789084 111 dbSNP
rs1002620013 114 dbSNP
rs1197059841 115 dbSNP
rs1456685317 122 dbSNP
rs753042346 126 dbSNP
rs1055575911 129 dbSNP
rs558927265 136 dbSNP
rs1002125906 152 dbSNP
rs1302975395 160 dbSNP
rs1353936621 160 dbSNP
rs1285937054 161 dbSNP
rs1448635621 163 dbSNP
rs1032731833 166 dbSNP
rs377438234 173 dbSNP
rs143251867 174 dbSNP
rs1400577332 178 dbSNP
rs1009868227 198 dbSNP
rs1405160755 199 dbSNP
rs1412043916 200 dbSNP
rs1019949867 201 dbSNP
rs866969268 211 dbSNP
rs1473408756 212 dbSNP
rs1406618687 226 dbSNP
rs1379825468 232 dbSNP
rs1026879371 233 dbSNP
rs887033467 234 dbSNP
rs1004120330 243 dbSNP
rs1221085386 248 dbSNP
rs1449697042 249 dbSNP
rs1315075838 251 dbSNP
rs1291760908 253 dbSNP
rs3752161 254 dbSNP
rs748363456 257 dbSNP
rs1306899268 258 dbSNP
rs1241719773 269 dbSNP
rs1376928607 271 dbSNP
rs1244961269 276 dbSNP
rs79890280 282 dbSNP
rs45573536 283 dbSNP
rs990059448 292 dbSNP
rs374106536 297 dbSNP
rs914121624 308 dbSNP
rs1483267730 310 dbSNP
rs974327077 311 dbSNP
rs920656197 314 dbSNP
rs930761485 317 dbSNP
rs1380966149 318 dbSNP
rs1411150531 322 dbSNP
rs563675480 323 dbSNP
rs1443690683 327 dbSNP
rs983442982 345 dbSNP
rs907904594 350 dbSNP
rs531540054 351 dbSNP
rs1045990441 353 dbSNP
rs1381232860 354 dbSNP
rs906120211 357 dbSNP
rs928265550 357 dbSNP
rs937489683 360 dbSNP
rs554080534 365 dbSNP
rs550037908 367 dbSNP
rs892886001 368 dbSNP
rs564988446 369 dbSNP
rs766481828 370 dbSNP
rs1048695856 371 dbSNP
rs527283110 371 dbSNP
rs1360265476 374 dbSNP
rs3833875 382 dbSNP
rs397822517 382 dbSNP
rs747896398 382 dbSNP
rs886986047 382 dbSNP
rs1427570449 383 dbSNP
rs1191937585 384 dbSNP
rs142481159 384 dbSNP
rs1477399926 385 dbSNP
rs1260724207 386 dbSNP
rs1195840690 388 dbSNP
rs1019519971 389 dbSNP
rs1255279430 393 dbSNP
rs901154688 393 dbSNP
rs1402660676 397 dbSNP
rs996822387 404 dbSNP
rs547157464 405 dbSNP
rs1018120286 411 dbSNP
rs565463225 412 dbSNP
rs757223909 413 dbSNP
rs1276687573 421 dbSNP
rs13228 424 dbSNP
rs952149803 426 dbSNP
rs1363279203 430 dbSNP
rs1211601143 432 dbSNP
rs1445937015 433 dbSNP
rs1360940436 438 dbSNP
rs1235308788 439 dbSNP
rs983557613 440 dbSNP
rs966889297 441 dbSNP
rs1421283333 442 dbSNP
rs758332718 443 dbSNP
rs1239641903 444 dbSNP
rs1172570877 446 dbSNP
rs114113304 447 dbSNP
rs770105666 448 dbSNP
rs1180022581 449 dbSNP
rs1483970690 453 dbSNP
rs981446705 453 dbSNP
rs1237548378 460 dbSNP
rs1407880083 463 dbSNP
rs927526269 467 dbSNP
rs938303848 468 dbSNP
rs537473149 470 dbSNP
rs34766623 475 dbSNP
rs1178878256 479 dbSNP
rs1259519286 484 dbSNP
rs1220885261 487 dbSNP
rs762898230 489 dbSNP
rs763854391 490 dbSNP
rs937631101 498 dbSNP
rs1332251346 502 dbSNP
rs931053508 503 dbSNP
rs1054624547 504 dbSNP
rs1446052998 514 dbSNP
rs1379446584 515 dbSNP
rs914756610 519 dbSNP
rs11559032 520 dbSNP
rs886929334 521 dbSNP
rs569624934 522 dbSNP
rs1162679968 525 dbSNP
rs537392483 531 dbSNP
rs890889704 532 dbSNP
rs1385727423 533 dbSNP
rs1177475573 537 dbSNP
rs778379784 537 dbSNP
rs1220810337 546 dbSNP
rs529786462 547 dbSNP
rs1198853069 548 dbSNP
rs1039779662 551 dbSNP
rs1265219682 554 dbSNP
rs1322148064 555 dbSNP
rs559205146 561 dbSNP
rs1198758693 569 dbSNP
rs114754037 570 dbSNP
rs995857453 575 dbSNP
rs1316263207 578 dbSNP
rs1050182608 587 dbSNP
rs1374696414 605 dbSNP
rs535246914 616 dbSNP
rs1026800333 621 dbSNP
rs774336353 624 dbSNP
rs1389820403 625 dbSNP
rs553575603 626 dbSNP
rs11559031 631 dbSNP
rs1478570208 634 dbSNP
rs1011388415 636 dbSNP
rs1021066333 638 dbSNP
rs1004060723 639 dbSNP
rs575011914 641 dbSNP
rs1427856762 642 dbSNP
rs1480133730 647 dbSNP
rs971471759 655 dbSNP
rs1171537483 661 dbSNP
rs1264753296 664 dbSNP
rs981436655 665 dbSNP
rs1402710843 669 dbSNP
rs1489647664 671 dbSNP
rs542325659 675 dbSNP
rs1408497669 681 dbSNP
rs1328438679 682 dbSNP
rs1035231113 683 dbSNP
rs927322878 684 dbSNP
rs1350191814 687 dbSNP
rs959618973 688 dbSNP
rs958975773 689 dbSNP
rs915543847 693 dbSNP
rs1438371573 695 dbSNP
rs990832858 708 dbSNP
rs1344846912 718 dbSNP
rs1361963848 722 dbSNP
rs984249544 723 dbSNP
rs1218700077 725 dbSNP
rs549557447 727 dbSNP
rs914849486 730 dbSNP
rs756899310 732 dbSNP
rs1375602719 734 dbSNP
rs1041876941 742 dbSNP
rs1481651434 744 dbSNP
rs912274589 755 dbSNP
rs1452512580 756 dbSNP
rs943829498 761 dbSNP
rs73933820 762 dbSNP
rs1267355486 763 dbSNP
rs1480429346 766 dbSNP
rs939820539 767 dbSNP
rs11122 769 dbSNP
rs1194472140 770 dbSNP
rs1425780573 771 dbSNP
rs45472902 773 dbSNP
rs1040867394 775 dbSNP
rs1474474832 776 dbSNP
rs1318846170 778 dbSNP
rs1167503849 780 dbSNP
rs1399406903 782 dbSNP
rs1414837183 785 dbSNP
rs1406842195 786 dbSNP
rs1469982632 787 dbSNP
rs1301112012 789 dbSNP
rs370782442 790 dbSNP
rs1400468488 791 dbSNP
rs1299980476 793 dbSNP
rs1244353921 802 dbSNP
rs1194485029 805 dbSNP
rs181552710 813 dbSNP
rs1226101527 818 dbSNP
rs564135833 821 dbSNP
rs1205882088 825 dbSNP
rs1358088553 836 dbSNP
rs1048757986 837 dbSNP
rs545839550 838 dbSNP
rs781193264 840 dbSNP
rs1290123897 841 dbSNP
rs1341154441 843 dbSNP
rs35349647 844 dbSNP
rs397803740 844 dbSNP
rs1049688018 845 dbSNP
rs1490289851 846 dbSNP
rs1004006853 848 dbSNP
rs138804183 857 dbSNP
rs1266000951 865 dbSNP
rs1445311083 866 dbSNP
rs371652458 870 dbSNP
rs1238243831 873 dbSNP
rs1367178990 878 dbSNP
rs1185508207 892 dbSNP
rs1473937723 894 dbSNP
rs1237826213 898 dbSNP
rs1003401230 901 dbSNP
rs532247156 903 dbSNP
rs1439385075 906 dbSNP
rs1273428930 909 dbSNP
rs1208956481 912 dbSNP
rs1384318854 917 dbSNP
rs1034337811 919 dbSNP
rs1246102543 920 dbSNP
rs958934983 921 dbSNP
rs1160344400 935 dbSNP
rs547220667 939 dbSNP
rs990180883 942 dbSNP
rs1022261332 943 dbSNP
rs1356706636 961 dbSNP
rs1334310113 964 dbSNP
rs967606632 973 dbSNP
rs367609688 974 dbSNP
rs571864579 974 dbSNP
rs1449928783 978 dbSNP
rs1165970798 980 dbSNP
rs1445368704 987 dbSNP
rs1177079712 988 dbSNP
rs559109120 988 dbSNP
rs978690424 989 dbSNP
rs1471288008 994 dbSNP
rs186951023 995 dbSNP
rs191228356 998 dbSNP
rs975544339 1000 dbSNP
rs1449606573 1004 dbSNP
rs78307152 1013 dbSNP
rs930939175 1018 dbSNP
rs952461068 1023 dbSNP
rs1352423551 1033 dbSNP
rs1048059719 1043 dbSNP
rs983808377 1045 dbSNP
rs1373618472 1046 dbSNP
rs1273842884 1049 dbSNP
rs908268356 1054 dbSNP
rs1344005025 1057 dbSNP
rs569594760 1063 dbSNP
rs375259530 1068 dbSNP
rs1360383791 1072 dbSNP
rs1156936426 1080 dbSNP
rs1444217954 1089 dbSNP
rs78230547 1092 dbSNP
rs551850884 1096 dbSNP
rs750105635 1097 dbSNP
rs976508286 1100 dbSNP
rs939950926 1101 dbSNP
rs1046252464 1102 dbSNP
rs922419128 1105 dbSNP
rs906390512 1108 dbSNP
rs1217354990 1109 dbSNP
rs932527910 1110 dbSNP
rs1277540371 1112 dbSNP
rs1217086688 1121 dbSNP
rs985750961 1122 dbSNP
rs543993672 1130 dbSNP
rs772966825 1130 dbSNP
rs779647779 1131 dbSNP
rs146334045 1132 dbSNP
rs749767656 1137 dbSNP
rs1433039007 1143 dbSNP
rs1042421064 1144 dbSNP
rs1175701067 1147 dbSNP
rs902549442 1152 dbSNP
rs1011953832 1154 dbSNP
rs1056590756 1157 dbSNP
rs1176897035 1160 dbSNP
rs1021620930 1161 dbSNP
rs967596529 1174 dbSNP
rs529827099 1182 dbSNP
rs776175563 1183 dbSNP
rs977666868 1185 dbSNP
rs1236381470 1194 dbSNP
rs1012436195 1196 dbSNP
rs1019841692 1197 dbSNP
rs888045725 1199 dbSNP
rs1005582264 1208 dbSNP
rs965898657 1218 dbSNP
rs755594516 1223 dbSNP
rs1447950572 1227 dbSNP
rs975613860 1228 dbSNP
rs961049958 1229 dbSNP
rs1302346026 1236 dbSNP
rs976456146 1242 dbSNP
rs1029379313 1250 dbSNP
rs920973077 1251 dbSNP
rs1337583264 1253 dbSNP
rs985313623 1256 dbSNP
rs1371099879 1258 dbSNP
rs553637608 1259 dbSNP
rs748576434 1260 dbSNP
rs539279811 1268 dbSNP
rs1325712257 1275 dbSNP
rs908238633 1278 dbSNP
rs939902612 1280 dbSNP
rs772496064 1282 dbSNP
rs773238482 1283 dbSNP
rs1249958967 1287 dbSNP
rs550094021 1289 dbSNP
rs1308600925 1292 dbSNP
rs532711727 1298 dbSNP
rs1248071595 1299 dbSNP
rs894548652 1303 dbSNP
rs535999215 1306 dbSNP
rs1316048000 1307 dbSNP
rs557438326 1314 dbSNP
rs1021562574 1316 dbSNP
rs895235758 1317 dbSNP
rs747283583 1330 dbSNP
rs903168167 1334 dbSNP
rs1349247584 1348 dbSNP
rs575616766 1350 dbSNP
rs771246006 1350 dbSNP
rs1199424255 1351 dbSNP
rs1177684213 1356 dbSNP
rs759239391 1362 dbSNP
rs1252139746 1370 dbSNP
rs1019789703 1374 dbSNP
rs965657428 1379 dbSNP
rs997419971 1380 dbSNP
rs1049223617 1381 dbSNP
rs887984235 1384 dbSNP
rs1028521944 1386 dbSNP
rs116667830 1390 dbSNP
rs1015156462 1392 dbSNP
rs983897100 1393 dbSNP
rs908312604 1397 dbSNP
rs997824889 1403 dbSNP
rs1029327856 1430 dbSNP
rs961004772 1433 dbSNP
rs1366603977 1435 dbSNP
rs1301288619 1443 dbSNP
rs764860639 1443 dbSNP
rs1302554757 1444 dbSNP
rs1347990075 1453 dbSNP
rs1366051317 1459 dbSNP
rs1157528861 1460 dbSNP
rs564302202 1463 dbSNP
rs927828265 1468 dbSNP
rs937983770 1469 dbSNP
rs1420096523 1470 dbSNP
rs1055358013 1473 dbSNP
rs1268624828 1474 dbSNP
rs1197962092 1475 dbSNP
rs562134668 1487 dbSNP
rs776740308 1488 dbSNP
rs946559791 1489 dbSNP
rs372343384 1492 dbSNP
rs903282753 1495 dbSNP
rs1318702831 1498 dbSNP
rs1262755242 1500 dbSNP
rs998772942 1503 dbSNP
rs762846211 1505 dbSNP
rs1406466355 1507 dbSNP
rs901412577 1513 dbSNP
rs997134399 1523 dbSNP
rs1028893963 1524 dbSNP
rs187734853 1525 dbSNP
rs1005738380 1532 dbSNP
rs1164889956 1534 dbSNP
rs529844471 1537 dbSNP
rs1489854554 1556 dbSNP
rs909366349 1556 dbSNP
rs763366272 1560 dbSNP
rs961119884 1564 dbSNP
rs1478531230 1565 dbSNP
rs1036547970 1568 dbSNP
rs1205727360 1569 dbSNP
rs541617995 1570 dbSNP
rs1261450277 1576 dbSNP
rs927686362 1577 dbSNP
rs1323966468 1592 dbSNP
rs1225152329 1600 dbSNP
rs1372190048 1600 dbSNP
rs1050775685 1607 dbSNP
rs114106969 1607 dbSNP
rs990728849 1611 dbSNP
rs1403483986 1612 dbSNP
rs1338240986 1618 dbSNP
rs138278560 1624 dbSNP
rs1407293930 1625 dbSNP
rs946517576 1626 dbSNP
rs1474718898 1627 dbSNP
rs1375214152 1630 dbSNP
rs1194028327 1637 dbSNP
rs1042205131 1639 dbSNP
rs1368000481 1639 dbSNP
rs1444028701 1644 dbSNP
rs924694602 1646 dbSNP
rs1205775819 1649 dbSNP
rs774120438 1657 dbSNP
rs1272012890 1662 dbSNP
rs552176127 1663 dbSNP
rs1341394116 1664 dbSNP
rs1041009144 1673 dbSNP
rs570446583 1677 dbSNP
rs1341155092 1678 dbSNP
rs967884982 1678 dbSNP
rs1216435060 1679 dbSNP
rs552454546 1682 dbSNP
rs1452897243 1686 dbSNP
rs1293660306 1691 dbSNP
rs1375622624 1691 dbSNP
rs1408528806 1693 dbSNP
rs1307181157 1694 dbSNP
rs1399284624 1695 dbSNP
rs999363973 1696 dbSNP
rs1424144768 1697 dbSNP
rs997275286 1702 dbSNP
rs1049983527 1704 dbSNP
rs1232450368 1712 dbSNP
rs888705093 1715 dbSNP
rs1439289054 1716 dbSNP
rs1357011010 1731 dbSNP
rs960607954 1732 dbSNP
rs189790384 1737 dbSNP
rs1293336030 1738 dbSNP
rs112621745 1740 dbSNP
rs1245983631 1740 dbSNP
rs1337875968 1740 dbSNP
rs544932850 1740 dbSNP
rs528834781 1741 dbSNP
rs1486546089 1748 dbSNP
rs75302157 1751 dbSNP
rs1184311938 1752 dbSNP
rs1260596237 1753 dbSNP
rs1165553441 1754 dbSNP
rs1424098443 1756 dbSNP
rs1166481134 1760 dbSNP
rs1387406925 1764 dbSNP
rs116439926 1770 dbSNP
rs1157024578 1772 dbSNP
rs1471076811 1779 dbSNP
rs774678300 1781 dbSNP
rs969820793 1785 dbSNP
rs1489840415 1798 dbSNP
rs568722065 1800 dbSNP
rs1003323891 1813 dbSNP
rs1222608629 1814 dbSNP
rs1361781100 1814 dbSNP
rs1315786083 1816 dbSNP
rs909304904 1817 dbSNP
rs1225112668 1818 dbSNP
rs1035080831 1819 dbSNP
rs1289392888 1820 dbSNP
rs1223215075 1821 dbSNP
rs1344205127 1822 dbSNP
rs1361518800 1827 dbSNP
rs1437344615 1829 dbSNP
rs959041494 1830 dbSNP
rs1402675533 1832 dbSNP
rs990899898 1832 dbSNP
rs182289140 1838 dbSNP
rs1408903347 1844 dbSNP
rs1175476477 1848 dbSNP
rs1479303502 1852 dbSNP
rs1431416258 1856 dbSNP
rs1200017116 1857 dbSNP
rs1022172451 1860 dbSNP
rs368347398 1866 dbSNP
rs1217242746 1867 dbSNP
rs1321828962 1868 dbSNP
rs1447226736 1868 dbSNP
rs560383368 1868 dbSNP
rs1036495660 1869 dbSNP
rs923474931 1870 dbSNP
rs1286626852 1873 dbSNP
rs1268497312 1875 dbSNP
rs569361496 1877 dbSNP
rs1389683990 1880 dbSNP
rs1336291391 1881 dbSNP
rs80024346 1882 dbSNP
rs1468072244 1883 dbSNP
rs1408021066 1884 dbSNP
rs1051140949 1885 dbSNP
rs1259564707 1887 dbSNP
rs764672645 1889 dbSNP
rs1184998631 1890 dbSNP
rs1187799749 1895 dbSNP
rs187699477 1897 dbSNP
rs565696985 1898 dbSNP
rs1242200916 1903 dbSNP
rs1201353225 1905 dbSNP
rs1006986739 1909 dbSNP
rs1265397361 1912 dbSNP
rs1372502609 1920 dbSNP
rs1307456570 1928 dbSNP
rs1271442070 1929 dbSNP
rs923802243 1930 dbSNP
rs1183416525 1934 dbSNP
rs934725657 1936 dbSNP
rs1409333110 1942 dbSNP
rs976841077 1944 dbSNP
rs922694085 1955 dbSNP
rs1385194335 1963 dbSNP
rs903614705 1964 dbSNP
rs1157559389 1969 dbSNP
rs1344620148 1970 dbSNP
rs1172419376 1976 dbSNP
rs1429880776 1979 dbSNP
rs1384073066 1980 dbSNP
rs932636237 1984 dbSNP
rs1446085489 1985 dbSNP
rs1030838049 1989 dbSNP
rs767356520 1992 dbSNP
rs1050195226 2000 dbSNP
rs960556121 2001 dbSNP
rs192662855 2011 dbSNP
rs749992285 2012 dbSNP
rs1231709066 2013 dbSNP
rs1380923380 2014 dbSNP
rs1451633847 2015 dbSNP
rs1309798114 2016 dbSNP
rs1361906607 2017 dbSNP
rs547753522 2021 dbSNP
rs760404603 2023 dbSNP
rs1023984695 2024 dbSNP
rs62120494 2024 dbSNP
rs941628484 2029 dbSNP
rs1037190713 2035 dbSNP
rs1299886498 2038 dbSNP
rs1410348152 2051 dbSNP
rs185270722 2056 dbSNP
rs897352584 2059 dbSNP
rs1003725487 2064 dbSNP
rs1306230051 2065 dbSNP
rs1425952823 2083 dbSNP
rs969394026 2084 dbSNP
rs1312219049 2087 dbSNP
rs1034741504 2089 dbSNP
rs1205057535 2090 dbSNP
rs894889319 2093 dbSNP
rs566399934 2098 dbSNP
rs188392045 2101 dbSNP
rs972162398 2102 dbSNP
rs757385047 2107 dbSNP
rs1233737306 2113 dbSNP
rs1471367809 2118 dbSNP
rs1175939670 2121 dbSNP
rs1314971113 2125 dbSNP
rs1407947403 2126 dbSNP
rs1480794628 2131 dbSNP
rs933504073 2133 dbSNP
rs1178751845 2136 dbSNP
rs986376171 2142 dbSNP
rs978000100 2143 dbSNP
rs1404178852 2146 dbSNP
rs1030892441 2150 dbSNP
rs1329809922 2153 dbSNP
rs1356013142 2156 dbSNP
rs1439792020 2161 dbSNP
rs1161869121 2162 dbSNP
rs942346195 2163 dbSNP
rs1297504681 2164 dbSNP
rs965824767 2167 dbSNP
rs976331007 2172 dbSNP
rs1368276452 2173 dbSNP
rs1435051549 2175 dbSNP
rs1224803053 2180 dbSNP
rs574353832 2181 dbSNP
rs533125537 2188 dbSNP
rs1485032868 2193 dbSNP
rs1262661247 2198 dbSNP
rs932770567 2199 dbSNP
rs1280882760 2202 dbSNP
rs903559115 2203 dbSNP
rs1281370916 2213 dbSNP
rs1322219432 2221 dbSNP
rs935047791 2222 dbSNP
rs8101444 2226 dbSNP
rs896294150 2227 dbSNP
rs1386717321 2229 dbSNP
rs569764493 2230 dbSNP
rs1439891542 2235 dbSNP
rs1405804165 2239 dbSNP
rs537155371 2241 dbSNP
rs563314125 2243 dbSNP
rs941575981 2247 dbSNP
rs1037264348 2250 dbSNP
rs897417791 2252 dbSNP
rs1479299163 2255 dbSNP
rs1378675178 2264 dbSNP
rs1192587259 2267 dbSNP
rs1426785023 2268 dbSNP
rs192833803 2288 dbSNP
rs555868276 2289 dbSNP
rs1006172422 2298 dbSNP
rs1490676730 2304 dbSNP
rs867432253 2314 dbSNP
rs1427219892 2315 dbSNP
rs1480164289 2317 dbSNP
rs1012435540 2320 dbSNP
rs1224673999 2321 dbSNP
rs962043960 2322 dbSNP
rs1168670868 2323 dbSNP
rs1421964854 2331 dbSNP
rs796742919 2332 dbSNP
rs1327999312 2333 dbSNP
rs1335149350 2334 dbSNP
rs1030391382 2335 dbSNP
rs1403598880 2337 dbSNP
rs879478041 2338 dbSNP
rs753273698 2339 dbSNP
rs986710671 2341 dbSNP
rs999163198 2342 dbSNP
rs1444240636 2349 dbSNP
rs910754221 2350 dbSNP
rs1189390315 2352 dbSNP
rs1442767048 2368 dbSNP
rs947622091 2369 dbSNP
rs1194005985 2370 dbSNP
rs1343755353 2371 dbSNP
rs1337108952 2373 dbSNP
rs979058944 2378 dbSNP
rs1182640809 2388 dbSNP
rs1356849798 2399 dbSNP
rs1213181212 2401 dbSNP
rs1030843391 2403 dbSNP
rs965940482 2404 dbSNP
rs184840808 2405 dbSNP
rs1052162863 2406 dbSNP
rs1424045214 2407 dbSNP
rs528095458 2414 dbSNP
rs1029276558 2415 dbSNP
rs954142254 2416 dbSNP
rs114561888 2417 dbSNP
rs1490197703 2420 dbSNP
rs1483999689 2423 dbSNP
rs1045294443 2426 dbSNP
rs905065252 2428 dbSNP
rs796999167 2429 dbSNP
rs1016164535 2431 dbSNP
rs1474587893 2432 dbSNP
rs1167557536 2437 dbSNP
rs1349434124 2439 dbSNP
rs1279341661 2441 dbSNP
rs962668296 2443 dbSNP
rs1352887678 2446 dbSNP
rs1309151695 2451 dbSNP
rs972730570 2452 dbSNP
rs897806356 2453 dbSNP
rs993462155 2454 dbSNP
rs1406189930 2456 dbSNP
rs1161551666 2457 dbSNP
rs778232769 2471 dbSNP
rs939632834 2474 dbSNP
rs1030338792 2481 dbSNP
rs1198590180 2481 dbSNP
rs568793154 2485 dbSNP
rs1247962341 2493 dbSNP
rs1207283172 2495 dbSNP
rs1331630363 2495 dbSNP
rs141893695 2495 dbSNP
rs374824487 2495 dbSNP
rs566315873 2495 dbSNP
rs1056619686 2498 dbSNP
rs1366040781 2500 dbSNP
rs1276698827 2501 dbSNP
rs1007680458 2504 dbSNP
rs775621588 2505 dbSNP
rs1318746521 2509 dbSNP
rs1324180545 2514 dbSNP
rs968941074 2515 dbSNP
rs1175368365 2519 dbSNP
rs1315338732 2519 dbSNP
rs59532686 2519 dbSNP
rs978977892 2521 dbSNP
rs924877554 2522 dbSNP
rs956323017 2522 dbSNP
rs987815197 2522 dbSNP
rs747169503 2523 dbSNP
rs916755940 2526 dbSNP
rs917624406 2527 dbSNP
rs949156700 2527 dbSNP
rs1044845293 2529 dbSNP
rs1466574801 2529 dbSNP
rs926436951 2532 dbSNP
rs568156566 2536 dbSNP
rs535666758 2541 dbSNP
rs897753896 2544 dbSNP
rs1043425829 2547 dbSNP
rs1286350413 2554 dbSNP
rs1445360815 2557 dbSNP
rs117191961 2566 dbSNP
rs1335876388 2571 dbSNP
rs1051712382 2576 dbSNP
rs188178043 2577 dbSNP
rs180791961 2578 dbSNP
rs1416756509 2583 dbSNP
rs901754062 2585 dbSNP
rs997871444 2586 dbSNP
rs1181590027 2588 dbSNP
rs969266134 2591 dbSNP
rs1028808010 2595 dbSNP
rs1454192745 2602 dbSNP
rs953311870 2611 dbSNP
rs1006067661 2612 dbSNP
rs1183393546 2616 dbSNP
rs1016990811 2623 dbSNP
rs1000370460 2624 dbSNP
rs1211421357 2629 dbSNP
rs962826361 2630 dbSNP
rs1382080537 2636 dbSNP
rs746013787 2645 dbSNP
rs918619614 2646 dbSNP
rs993120456 2652 dbSNP
rs960967732 2655 dbSNP
rs992793660 2656 dbSNP
rs1226436305 2658 dbSNP
rs1381068980 2663 dbSNP
rs868835219 2666 dbSNP
rs1313460182 2667 dbSNP
rs1340252587 2670 dbSNP
rs1240312017 2677 dbSNP
rs1309358201 2680 dbSNP
rs747959092 2685 dbSNP
rs1348574869 2687 dbSNP
rs948187657 2689 dbSNP
rs539972592 2693 dbSNP
rs1043877297 2694 dbSNP
rs557976127 2701 dbSNP
rs879326816 2702 dbSNP
rs113368042 2709 dbSNP
rs1202017815 2712 dbSNP
rs1242248518 2719 dbSNP
rs1480609846 2720 dbSNP
rs777798434 2722 dbSNP
rs941833161 2725 dbSNP
rs1037488685 2727 dbSNP
rs545787354 2728 dbSNP
rs929205107 2731 dbSNP
rs533945947 2737 dbSNP
rs890421305 2738 dbSNP
rs1007574795 2739 dbSNP
rs933020982 2740 dbSNP
rs1290117676 2744 dbSNP
rs1409949862 2746 dbSNP
rs183925529 2753 dbSNP
rs1291229239 2756 dbSNP
rs889040172 2757 dbSNP
rs1459122247 2760 dbSNP
rs904615794 2763 dbSNP
rs574418389 2765 dbSNP
rs1165954704 2766 dbSNP
rs1472456122 2767 dbSNP
rs1000317847 2777 dbSNP
rs1184962427 2779 dbSNP
rs1006054326 2798 dbSNP
rs889906214 2798 dbSNP
rs1401879522 2804 dbSNP
rs1016139554 2806 dbSNP
rs898568387 2816 dbSNP
rs994274324 2817 dbSNP
rs1025749631 2822 dbSNP
rs1489609039 2825 dbSNP
rs1266215188 2830 dbSNP
rs960961714 2834 dbSNP
rs1014502751 2838 dbSNP
rs1024574334 2847 dbSNP
rs774214713 2848 dbSNP
rs541740146 2853 dbSNP
rs970776618 2854 dbSNP
rs1344718005 2863 dbSNP
rs1298593005 2865 dbSNP
rs1334560202 2869 dbSNP
rs761831348 2872 dbSNP
rs1227859133 2878 dbSNP
rs1033797091 2880 dbSNP
rs1386894888 2883 dbSNP
rs1325778518 2884 dbSNP
rs557160269 2887 dbSNP
rs139648087 2892 dbSNP
rs1255662634 2895 dbSNP
rs1377523166 2902 dbSNP
rs1024269157 2907 dbSNP
rs919077103 2909 dbSNP
rs969708600 2918 dbSNP
rs545935150 2921 dbSNP
rs1463663827 2927 dbSNP
rs1269786966 2933 dbSNP
rs979564590 2934 dbSNP
rs1209072216 2935 dbSNP
rs1480819747 2938 dbSNP
rs925485028 2945 dbSNP
rs564179133 2949 dbSNP
rs1234833453 2955 dbSNP
rs987826415 2963 dbSNP
rs572187228 2965 dbSNP
rs1432467987 2967 dbSNP
rs1366834997 2969 dbSNP
rs189441052 2974 dbSNP
rs1436212889 2978 dbSNP
rs1402183557 2994 dbSNP
rs923059836 2995 dbSNP
rs943332487 2996 dbSNP
rs1479180518 2997 dbSNP
rs540260836 3003 dbSNP
rs1167962424 3012 dbSNP
rs1175209097 3013 dbSNP
rs561652902 3023 dbSNP
rs368747005 3024 dbSNP
rs904563481 3029 dbSNP
rs868752352 3034 dbSNP
rs1409693821 3037 dbSNP
rs1304304209 3038 dbSNP
rs1347431902 3041 dbSNP
rs371416912 3042 dbSNP
rs936054195 3044 dbSNP
rs1225495764 3046 dbSNP
rs550991668 3051 dbSNP
rs941954936 3057 dbSNP
rs1037520601 3059 dbSNP
rs1398307005 3063 dbSNP
rs563152995 3063 dbSNP
rs993340951 3064 dbSNP
rs1026114080 3069 dbSNP
rs1169461000 3071 dbSNP
rs773096111 3073 dbSNP
rs1014003369 3074 dbSNP
rs1023672747 3076 dbSNP
rs1189282282 3081 dbSNP
rs1442967172 3089 dbSNP
rs760219661 3091 dbSNP
rs182340970 3092 dbSNP
rs551522954 3095 dbSNP
rs566644158 3096 dbSNP
rs1032574602 3097 dbSNP
rs1282820634 3098 dbSNP
rs111994476 3104 dbSNP
rs988276320 3105 dbSNP
rs1408148218 3106 dbSNP
rs1429859619 3109 dbSNP
rs548997342 3111 dbSNP
rs933117544 3120 dbSNP
rs1164805734 3125 dbSNP
rs1429549785 3127 dbSNP
rs1411206436 3130 dbSNP
rs1179925425 3132 dbSNP
rs1473322511 3137 dbSNP
rs1251929470 3140 dbSNP
rs986187092 3147 dbSNP
rs1368064835 3149 dbSNP
rs910242461 3151 dbSNP
rs891889092 3157 dbSNP
rs941693726 3164 dbSNP
rs1335904114 3170 dbSNP
rs766188729 3176 dbSNP
rs1037591970 3179 dbSNP
rs919182182 3181 dbSNP
rs567542291 3186 dbSNP
rs115833748 3187 dbSNP
rs1362753038 3198 dbSNP
rs896556678 3203 dbSNP
rs1293726216 3204 dbSNP
rs1013703099 3213 dbSNP
rs112553953 3214 dbSNP
rs1387624221 3215 dbSNP
rs1156617293 3220 dbSNP
rs1039038682 3227 dbSNP
rs1412553440 3229 dbSNP
rs575453140 3231 dbSNP
rs1293827019 3232 dbSNP
rs905179957 3239 dbSNP
rs1000835291 3249 dbSNP
rs898809876 3251 dbSNP
rs1464116728 3252 dbSNP
rs1032523720 3255 dbSNP
rs956955792 3260 dbSNP
rs539279051 3262 dbSNP
rs557963353 3266 dbSNP
rs759062873 3267 dbSNP
rs1218764490 3270 dbSNP
rs954593393 3284 dbSNP
rs1276892427 3290 dbSNP
rs1441940350 3292 dbSNP
rs77178223 3295 dbSNP
rs910314836 3301 dbSNP
rs1202960243 3305 dbSNP
rs1018763650 3307 dbSNP
rs868077679 3308 dbSNP
rs973066310 3310 dbSNP
rs974659693 3312 dbSNP
rs925880165 3313 dbSNP
rs111353239 3320 dbSNP
rs1448532917 3322 dbSNP
rs561715428 3323 dbSNP
rs573561666 3327 dbSNP
rs929243548 3330 dbSNP
rs1210016691 3331 dbSNP
rs544156681 3331 dbSNP
rs1441134815 3335 dbSNP
rs34725740 3336 dbSNP
rs397752605 3336 dbSNP
rs67192765 3337 dbSNP
rs917115560 3337 dbSNP
rs1341777771 3338 dbSNP
rs1388240956 3339 dbSNP
rs1046263157 3340 dbSNP
rs563056629 3341 dbSNP
rs1301984028 3343 dbSNP
rs1445738831 3345 dbSNP
rs1360784772 3352 dbSNP
rs764865329 3353 dbSNP
rs1428513866 3356 dbSNP
rs868388853 3361 dbSNP
rs927454131 3365 dbSNP
rs1380328357 3370 dbSNP
rs139454118 3385 dbSNP
rs1045127898 3386 dbSNP
rs1420689978 3389 dbSNP
rs1181575844 3391 dbSNP
rs905295989 3393 dbSNP
rs1239697175 3398 dbSNP
rs1211731471 3399 dbSNP
rs1000784396 3400 dbSNP
rs1213099138 3407 dbSNP
rs551584792 3408 dbSNP
rs1311779273 3409 dbSNP
rs1226350845 3410 dbSNP
rs1381313047 3411 dbSNP
rs994415513 3413 dbSNP
rs560295585 3422 dbSNP
rs1368151090 3429 dbSNP
rs186794958 3431 dbSNP
rs753218463 3432 dbSNP
rs1205178024 3434 dbSNP
rs886129277 3436 dbSNP
rs1348901970 3458 dbSNP
rs1009845093 3460 dbSNP
rs758986292 3463 dbSNP
rs1181743257 3464 dbSNP
rs1019123115 3465 dbSNP
rs1409403790 3466 dbSNP
rs964553882 3469 dbSNP
rs954870074 3473 dbSNP
rs1157107806 3480 dbSNP
rs1032895945 3481 dbSNP
rs1008147247 3486 dbSNP
rs957271146 3487 dbSNP
rs1017324947 3491 dbSNP
rs988750987 3493 dbSNP
rs191637905 3496 dbSNP
rs1273799392 3499 dbSNP
rs543540126 3502 dbSNP
rs1348484482 3503 dbSNP
rs567704641 3507 dbSNP
rs1298662351 3509 dbSNP
rs927371843 3510 dbSNP
rs937489647 3511 dbSNP
rs1287089798 3512 dbSNP
rs1323638744 3522 dbSNP
rs1434831214 3527 dbSNP
rs1397156853 3528 dbSNP
rs1166020675 3537 dbSNP
rs1457204892 3555 dbSNP
rs1410335000 3568 dbSNP
rs1161438227 3572 dbSNP
rs950676683 3577 dbSNP
rs537861002 3578 dbSNP
rs550113445 3580 dbSNP
rs1267022248 3586 dbSNP
rs1310772056 3591 dbSNP
rs1209917817 3598 dbSNP
rs1233952137 3599 dbSNP
rs942391777 3601 dbSNP
rs144976332 3605 dbSNP
rs920135529 3610 dbSNP
rs781324711 3611 dbSNP
rs992737620 3619 dbSNP
rs751918009 3627 dbSNP
rs762271649 3628 dbSNP
rs917167079 3629 dbSNP
rs748189115 3631 dbSNP
rs1480823542 3633 dbSNP
rs539730050 3636 dbSNP
rs1269924790 3639 dbSNP
rs930212874 3640 dbSNP
rs1311087618 3641 dbSNP
rs1298482427 3653 dbSNP
rs1423386353 3654 dbSNP
rs948548214 3656 dbSNP
rs1413691291 3670 dbSNP
rs1327020063 3672 dbSNP
rs1434794548 3681 dbSNP
rs147590472 3684 dbSNP
rs1356070971 3685 dbSNP
rs750597635 3689 dbSNP
rs76922779 3691 dbSNP
rs1439855232 3697 dbSNP
rs944390250 3707 dbSNP
rs1345547405 3715 dbSNP
rs1395871701 3729 dbSNP
rs1406281152 3737 dbSNP
rs926707891 3750 dbSNP
rs936785864 3751 dbSNP
rs1280948098 3767 dbSNP
rs1053694659 3768 dbSNP
rs1343926062 3773 dbSNP
rs892442897 3774 dbSNP
rs769813992 3782 dbSNP
rs1234719487 3784 dbSNP
rs1348212064 3790 dbSNP
rs142025812 3796 dbSNP
rs995965676 3797 dbSNP
rs1032827229 3807 dbSNP
rs890703449 3818 dbSNP
rs1298096718 3829 dbSNP
rs1383280451 3829 dbSNP
rs1402057517 3832 dbSNP
rs573072151 3833 dbSNP
rs555180758 3834 dbSNP
rs1274603798 3839 dbSNP
rs1490528132 3841 dbSNP
rs1376340503 3852 dbSNP
rs1201760178 3854 dbSNP
rs1447820537 3856 dbSNP
rs573649359 3858 dbSNP
rs1245201888 3867 dbSNP
rs1193574678 3870 dbSNP
rs1477785361 3878 dbSNP
rs1423207568 3879 dbSNP
rs1020229563 3884 dbSNP
rs971382354 3886 dbSNP
rs981854866 3889 dbSNP
rs898903634 3898 dbSNP
rs994614704 3902 dbSNP
rs1340967132 3908 dbSNP
rs1272309655 3909 dbSNP
rs748001413 3913 dbSNP
rs1366163846 3918 dbSNP
rs1425987981 3925 dbSNP
rs1340438867 3931 dbSNP
rs950385446 3933 dbSNP
rs1416777207 3941 dbSNP
rs543884763 3946 dbSNP
rs959042793 3956 dbSNP
rs992912793 3958 dbSNP
rs1024186923 3960 dbSNP
rs920081688 3961 dbSNP
rs10405422 3964 dbSNP
rs1366706421 3969 dbSNP
rs979891949 3971 dbSNP
rs578210792 3976 dbSNP
rs181168371 3977 dbSNP
rs1250438079 3979 dbSNP
rs560361415 3996 dbSNP
rs1297493051 4004 dbSNP
rs185375809 4005 dbSNP
rs542770493 4006 dbSNP
rs561240846 4009 dbSNP
rs1356070035 4012 dbSNP
rs1052235961 4023 dbSNP
rs1336045101 4029 dbSNP
rs1451135013 4034 dbSNP
rs1287846187 4042 dbSNP
rs1408046630 4046 dbSNP
rs1337807657 4055 dbSNP
rs758386391 4064 dbSNP
rs1184360628 4077 dbSNP
rs141115599 4081 dbSNP
rs1244093350 4082 dbSNP
rs1166752475 4086 dbSNP
rs931706239 4090 dbSNP
rs1411088254 4091 dbSNP
rs1054217354 4092 dbSNP
rs890704290 4094 dbSNP
rs549942436 4097 dbSNP
rs368919226 4098 dbSNP
rs113525787 4099 dbSNP
rs72310827 4099 dbSNP
rs892950905 4099 dbSNP
rs571607391 4101 dbSNP
rs781418277 4101 dbSNP
rs899310121 4102 dbSNP
rs533313591 4103 dbSNP
rs995020093 4105 dbSNP
rs1352930442 4109 dbSNP
rs1002830293 4112 dbSNP
rs2319153 4113 dbSNP
rs1368987058 4114 dbSNP
rs958729230 4119 dbSNP
rs974102219 4120 dbSNP
rs1386075023 4121 dbSNP
rs533445362 4123 dbSNP
rs1318441904 4124 dbSNP
rs1027047318 4125 dbSNP
rs770866256 4127 dbSNP
rs886191428 4128 dbSNP
rs1408094574 4130 dbSNP
rs566736004 4133 dbSNP
rs1013920104 4134 dbSNP
rs1024426138 4149 dbSNP
rs912765400 4151 dbSNP
rs1248022879 4152 dbSNP
rs969981586 4155 dbSNP
rs1449179615 4167 dbSNP
rs533994934 4174 dbSNP
rs776377983 4175 dbSNP
rs1346038625 4198 dbSNP
rs1305868461 4200 dbSNP
rs555511835 4205 dbSNP
rs957168288 4206 dbSNP
rs1268143056 4212 dbSNP
rs1178234985 4218 dbSNP
rs1208349236 4219 dbSNP
rs1054165584 4220 dbSNP
rs1345676183 4222 dbSNP
rs1462502285 4222 dbSNP
rs914330427 4224 dbSNP
rs1185293101 4225 dbSNP
rs1367872335 4227 dbSNP
rs1470186773 4228 dbSNP
rs1159862622 4230 dbSNP
rs1409140050 4232 dbSNP
rs892012 4235 dbSNP
rs1337011311 4236 dbSNP
rs1186990262 4238 dbSNP
rs1282812840 4238 dbSNP
rs1484723126 4238 dbSNP
rs1485852883 4238 dbSNP
rs35892153 4238 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agugucaacggucgACUCUAAu 5'
                        ||||||| 
Target 5' -------------aUGAGAUUu 3'
1 - 9
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000599386.1 | 3UTR | AUGAGAUUUUUUUUUUUUUUUUGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000599386.1 | 3UTR | AUGAGAUUUUUUUUUUUUUUUUGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE14794 Lymphoblastoid cells -0.251 8.5e-3 -0.194 3.3e-2 90 Click to see details
GSE28544 Breast cancer 0.408 2.4e-2 0.441 1.5e-2 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.374 3.6e-2 0.383 3.2e-2 24 Click to see details
GSE27834 Pluripotent stem cells 0.455 3.8e-2 0.412 5.6e-2 16 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.395 4.2e-2 0.087 3.6e-1 20 Click to see details
GSE17498 Multiple myeloma -0.228 7.9e-2 -0.158 1.7e-1 40 Click to see details
GSE19350 CNS germ cell tumors 0.32 1.6e-1 0.512 4.4e-2 12 Click to see details
GSE32688 Pancreatic cancer -0.144 2.2e-1 -0.055 3.8e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.069 2.9e-1 0.084 2.5e-1 64 Click to see details
GSE17306 Multiple myeloma 0.074 3.1e-1 0.401 2.1e-3 49 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.091 3.3e-1 -0.256 1.1e-1 25 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.075 3.6e-1 0.479 7.7e-3 25 Click to see details
GSE21849 B cell lymphoma 0.056 3.9e-1 0.202 1.5e-1 29 Click to see details
GSE28260 Renal cortex and medulla 0.081 4.0e-1 0.021 4.7e-1 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.052 4.1e-1 0.005 4.9e-1 23 Click to see details
GSE38226 Liver fibrosis 0.053 4.1e-1 0.259 1.3e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.566 0 -0.432 0.02 23 Click to see details
BLCA 0.766 0 0.697 0.01 10 Click to see details
KIRP -0.562 0.01 -0.519 0.01 18 Click to see details
LIHC -0.224 0.07 -0.156 0.15 45 Click to see details
PRAD 0.206 0.13 0.281 0.06 31 Click to see details
LUSC -0.242 0.15 -0.191 0.21 20 Click to see details
KICH -0.233 0.25 -0.109 0.37 11 Click to see details
PAAD 0.426 0.29 0.200 0.4 4 Click to see details
THCA 0.084 0.29 0.161 0.14 47 Click to see details
ESCA -0.411 0.29 -0.600 0.2 4 Click to see details
LUAD 0.206 0.3 0.167 0.33 9 Click to see details
KIRC 0.102 0.3 0.027 0.44 29 Click to see details
BRCA -0.092 0.33 -0.093 0.33 25 Click to see details
UCEC -0.145 0.34 -0.442 0.1 10 Click to see details
CHOL 0.083 0.42 0.357 0.19 8 Click to see details
STAD 0.01 0.48 -0.120 0.31 20 Click to see details
STAD 0.01 0.48 -0.120 0.31 20 Click to see details
STAD 0.01 0.48 -0.120 0.31 20 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission