pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol GSTCD   
Synonyms -
Description glutathione S-transferase C-terminal domain containing
Transcript NM_001031720   
Other Transcripts NM_024751   
Expression
Putative miRNA Targets on GSTCD
3'UTR of GSTCD
(miRNA target sites are highlighted)
>GSTCD|NM_001031720|3'UTR
   1 AATGAGATATTCACATTTGATATTTTGCCATCCGTCTTCACGTTGGATGCCCAGTGGCATTCAGGAGGTTCTTGGCATAA
  81 CTAGGAAACAGCATTAGCCATCTTGAACCTATTGTGCTCAGGAAGGAAAGCAACAGGGAAATCTTGGAAGTAAAGGCTCC
 161 CTGCAAAGCATCACAAATGCTTTACAATGTGTGATTAAAGGACTGCTGGTTTTTATAGTGAGAATCCCCTGAAGTCTCAG
 241 CTGCCAAAAGAATAATACTAGTGGAGGTTCCATCACAGGAATAACAATTTCCTTCTCACTTCACAAGCTCCTCTGATCTT
 321 GCCAATGTGATGTTTAATTCAAAACAGCGCACTTACAGCCTTTATTTTATACTTATTTAGATATTCACATGGGAACTGAA
 401 AGTAGACTCAGTGGAGTTTTTTGTTTTTTATATTTTTAACAATTGTACTTTTTCTATCACTTTAAAAAAATCTAGTCAGG
 481 TAATTATAGTACAGTTATTTTTAAGCTGGGGTTAGTTGAACTTGTATAGCATTTAATATACTCCTTTTAAATATATTTCT
 561 GCCAGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGAGAGGCCAAGGTGGGAGGATCATTTGAGCCCAGGATATCG
 641 AGACCAGCCTGCACTACAAAAAAATCCAAAAAATGAGGTGGGAGGATCACTTGAGCCCAGGAAGTCAAGGCTGCAGTGAG
 721 CCTTGATAGCGCCACTGCACTCCTGCCTGGGAAAATGAGACCCAGACTCAAAATAAATCAATGAATGAATTAATAAACAA
 801 ATAAATAAATAAATAAATTTCCCATAAATTACCAAATGAGATTGTCACTGGTTCAAATTATTAAATAATTGCCATAAATT
 881 TCCTATTACGGGAATGTGGAATTTGGACATACATTTTAACAATAAGTACATTGATTAATACATTTAAGTTTATAAGTAAT
 961 TATTGAGGATCCAGTATTTTCAAGACCTTGGCCTAGTTTCTTTTCAATTCAAAGATGAGTTGCAAAAGACATAATGTTTT
1041 GCCTATGGAAGTAGATCATCTAGAAGAAAAAGATTAAAGAATTAGTTAAGCTTTTTTTTTTTTTTTTTTTTGAGACAGAG
1121 TTTCACTCTTGTTGCCCAGGCTGGAATTCAGTGGCTCGATCTTGGCTCACCACAACCTCTGCATTCTCCTGCCTCAGCCT
1201 CCCGAGTAGCTAGGATTATAGGCACCTGCCACCATGCCCGGCTAATTTTGTTTGTAATTTTAGTAGAGATGGGGTTTCTC
1281 CATGTTGGCCAGGCTGGTTTCGAACTCCTGACCTCAGGTGATCTACCCGCCTCAGCCTCCCAAAGTGCTGAAATTACAGG
1361 CGTGAGCCACCTCACCTGGCCATGTTCTTTATGGAATACTACAATGTGTTGTCACAGGATTTGTTATTCAGATGTCAATC
1441 ATTTTTATTTATATATTTCTGGGTAAAACTTATTAGTGGTGTGAGGAGTGCAGAATATGGAAGCTTACCTAAATTCTTTT
1521 TCTGCCAGCCAACATTTTAAAAGACAAATGATGCATCCTTTCTCAATGCTGCTAATTCTTTAAATTTTACATGTCCCAAT
1601 TTATTCCATTTGAGATTTATTTTAATGTTTTCAACCCCTGTGTAACATGTATCATGAGGAGAAAGCACTATCATTGATCA
1681 TCACTATGGATTAAAATATAGGAATATTTTACAGGGCAGTATGGGTGGGGGTGGGAGACATATTGGAATCGTGTTTTCTG
1761 GGATAAAATTTTTAAAAAGAATTAATCATTAGCCCTGAGTATTTTAGTCATTTGTGCCTATAGAAAACAACATGCTCTTT
1841 TATTGTGGACTTTCTTCTTTTAAGTGAGGTTTAATTTATATACAATACAATAACAGATTTTTAAGTATTCATTTGAGATG
1921 TTTTGACAACTGTATATATACATGTAACCATCACTGGAATCAGATATAGAATATTCCCCTTAAATATTGTCAGGTAAACA
2001 CATTGAGAATATTTTTTCCAGTCTGTGGCTTACCTACTTATTTTCATAATGAATGTTTTACTTGTGATGAAGATTTAACT
2081 TACCCTTTTACTTTAATGATTAATATTTTCTGTGTTCTTTCTAATAAATTTTACGAACTCTGAGGTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacaUCCGGAAAUCUAGUGAa 5'
              |||:    :||||||| 
Target 5' aatgAGGTGGGAGGATCACTt 3'
672 - 692 145.00 -15.40
2
miRNA  3' uacaUCCGGAAAUCUAGUGAa 5'
              |||:    :|||||:| 
Target 5' gccaAGGTGGGAGGATCATTt 3'
605 - 625 129.00 -13.20
3
miRNA  3' uaCAUCCGGAAAUCUAGUGAa 5'
            |||  ::|||  |||||| 
Target 5' ttGTA-CTTTTTCTATCACTt 3'
443 - 462 126.00 -8.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN508521 32 COSMIC
COSN508520 47 COSMIC
COSN30478410 53 COSMIC
COSN31601795 72 COSMIC
COSN18718091 100 COSMIC
COSN32001126 111 COSMIC
COSN1284756 137 COSMIC
COSN19563835 198 COSMIC
COSN6789114 326 COSMIC
COSN32057683 493 COSMIC
COSN17078274 758 COSMIC
COSN20091095 949 COSMIC
COSN20100404 971 COSMIC
COSN6789115 1402 COSMIC
COSN7722441 1752 COSMIC
COSN5151066 1798 COSMIC
COSN9583349 1881 COSMIC
COSN22365784 2026 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1423190966 5 dbSNP
rs1302116419 8 dbSNP
rs369159127 14 dbSNP
rs1432235539 15 dbSNP
rs765150544 16 dbSNP
rs1361114135 28 dbSNP
rs1246628167 29 dbSNP
rs200203562 31 dbSNP
rs755303914 34 dbSNP
rs781698183 35 dbSNP
rs372937091 42 dbSNP
rs750227530 42 dbSNP
rs376011427 43 dbSNP
rs756696780 47 dbSNP
rs778366533 50 dbSNP
rs1007370667 82 dbSNP
rs1211184215 87 dbSNP
rs577356805 90 dbSNP
rs1369686112 93 dbSNP
rs1305113352 100 dbSNP
rs1231668447 109 dbSNP
rs933427816 110 dbSNP
rs1297675912 112 dbSNP
rs1436724806 112 dbSNP
rs186481180 114 dbSNP
rs1162558874 115 dbSNP
rs968653378 131 dbSNP
rs988886668 143 dbSNP
rs913263647 146 dbSNP
rs563018058 151 dbSNP
rs576539660 162 dbSNP
rs1466317102 167 dbSNP
rs1360713071 170 dbSNP
rs1171567804 175 dbSNP
rs1431579862 180 dbSNP
rs1434318447 188 dbSNP
rs1391083220 195 dbSNP
rs191003049 196 dbSNP
rs1369725115 203 dbSNP
rs1043037599 206 dbSNP
rs1396822898 210 dbSNP
rs562017083 211 dbSNP
rs182949214 216 dbSNP
rs745466766 217 dbSNP
rs1182980469 220 dbSNP
rs1338753462 227 dbSNP
rs1244207430 234 dbSNP
rs547564942 235 dbSNP
rs1270874221 236 dbSNP
rs955651482 241 dbSNP
rs1210685862 248 dbSNP
rs992585436 257 dbSNP
rs916976502 262 dbSNP
rs1305280927 263 dbSNP
rs1057493664 267 dbSNP
rs560344722 278 dbSNP
rs1396501096 283 dbSNP
rs1045214748 285 dbSNP
rs1310834701 293 dbSNP
rs1414010900 300 dbSNP
rs895981091 307 dbSNP
rs1170733757 316 dbSNP
rs1013319673 330 dbSNP
rs1274281568 347 dbSNP
rs372971193 348 dbSNP
rs1026004170 349 dbSNP
rs376113348 350 dbSNP
rs769171126 351 dbSNP
rs1426057847 355 dbSNP
rs1256100723 371 dbSNP
rs1187591558 387 dbSNP
rs1285578886 388 dbSNP
rs781633135 396 dbSNP
rs1006315065 397 dbSNP
rs1015895258 404 dbSNP
rs1252024204 410 dbSNP
rs1483592372 410 dbSNP
rs897839075 418 dbSNP
rs964988313 422 dbSNP
rs1337083723 424 dbSNP
rs1200661107 425 dbSNP
rs1250244553 432 dbSNP
rs532188570 435 dbSNP
rs1052301742 438 dbSNP
rs890527307 444 dbSNP
rs1291368907 446 dbSNP
rs1007833834 452 dbSNP
rs1440371243 463 dbSNP
rs1331093014 464 dbSNP
rs1350912785 464 dbSNP
rs1389861857 476 dbSNP
rs1396110369 477 dbSNP
rs138715240 481 dbSNP
rs1294187051 483 dbSNP
rs1459511456 487 dbSNP
rs28488297 493 dbSNP
rs1164856918 506 dbSNP
rs904480676 509 dbSNP
rs1414610478 511 dbSNP
rs1180166075 518 dbSNP
rs1000115235 519 dbSNP
rs1451183008 542 dbSNP
rs770262077 555 dbSNP
rs1031558056 558 dbSNP
rs537717926 565 dbSNP
rs1213029128 575 dbSNP
rs1389306096 583 dbSNP
rs992470704 585 dbSNP
rs1024496346 586 dbSNP
rs913337027 592 dbSNP
rs1466403946 595 dbSNP
rs947464897 599 dbSNP
rs1304777023 603 dbSNP
rs1329823227 614 dbSNP
rs1281051856 615 dbSNP
rs1236696408 621 dbSNP
rs868633198 630 dbSNP
rs1335324834 635 dbSNP
rs746496010 640 dbSNP
rs1443127203 641 dbSNP
rs927315027 642 dbSNP
rs547782487 643 dbSNP
rs1458208103 647 dbSNP
rs1387845766 648 dbSNP
rs1157187803 650 dbSNP
rs1469952200 655 dbSNP
rs1362802830 664 dbSNP
rs969818526 668 dbSNP
rs981380096 675 dbSNP
rs926816505 676 dbSNP
rs1480085562 679 dbSNP
rs1321235363 680 dbSNP
rs937624291 681 dbSNP
rs1367444275 696 dbSNP
rs1203094598 700 dbSNP
rs1286263047 700 dbSNP
rs1349714403 702 dbSNP
rs201940185 714 dbSNP
rs1256765339 716 dbSNP
rs1236731567 717 dbSNP
rs575386694 723 dbSNP
rs1297582381 731 dbSNP
rs1057368673 732 dbSNP
rs1328640711 740 dbSNP
rs896013865 741 dbSNP
rs2553444 757 dbSNP
rs1175965393 758 dbSNP
rs973641018 767 dbSNP
rs919489133 772 dbSNP
rs1192383910 782 dbSNP
rs1243724782 792 dbSNP
rs370066116 792 dbSNP
rs1051756269 795 dbSNP
rs372374573 796 dbSNP
rs533680319 798 dbSNP
rs1212829368 799 dbSNP
rs377122745 799 dbSNP
rs56671596 799 dbSNP
rs796080602 799 dbSNP
rs886198454 806 dbSNP
rs1005928656 810 dbSNP
rs943464617 811 dbSNP
rs200199654 816 dbSNP
rs1279887572 838 dbSNP
rs187496632 842 dbSNP
rs1341590797 844 dbSNP
rs1039489303 845 dbSNP
rs1430609040 851 dbSNP
rs1341645071 852 dbSNP
rs1037809977 856 dbSNP
rs1413398016 857 dbSNP
rs1465909874 875 dbSNP
rs1373176896 880 dbSNP
rs1000000969 881 dbSNP
rs1186572416 884 dbSNP
rs1409997385 884 dbSNP
rs75817507 890 dbSNP
rs1247386630 891 dbSNP
rs1475034525 898 dbSNP
rs996525245 900 dbSNP
rs1189720033 907 dbSNP
rs1484575766 920 dbSNP
rs878915970 932 dbSNP
rs771018995 934 dbSNP
rs1014364425 936 dbSNP
rs1439822433 938 dbSNP
rs1375732543 942 dbSNP
rs954585694 943 dbSNP
rs539627858 948 dbSNP
rs1465669719 953 dbSNP
rs201806609 970 dbSNP
rs746989308 970 dbSNP
rs145728883 973 dbSNP
rs556691015 975 dbSNP
rs1020091064 987 dbSNP
rs1214122694 1001 dbSNP
rs17036337 1008 dbSNP
rs978861049 1009 dbSNP
rs17036339 1010 dbSNP
rs1368863249 1011 dbSNP
rs958717508 1024 dbSNP
rs1442452150 1027 dbSNP
rs1355974161 1032 dbSNP
rs1389051868 1033 dbSNP
rs746452126 1045 dbSNP
rs992767361 1061 dbSNP
rs1299565464 1063 dbSNP
rs917513824 1066 dbSNP
rs1312048473 1069 dbSNP
rs892144407 1073 dbSNP
rs930196519 1078 dbSNP
rs1009711987 1080 dbSNP
rs919539853 1089 dbSNP
rs1268425239 1091 dbSNP
rs1203830028 1092 dbSNP
rs1275548960 1092 dbSNP
rs1421090561 1092 dbSNP
rs535829428 1092 dbSNP
rs71586114 1092 dbSNP
rs929552117 1105 dbSNP
rs75596418 1110 dbSNP
rs1330567874 1112 dbSNP
rs1187375551 1113 dbSNP
rs1266961755 1114 dbSNP
rs1225899174 1117 dbSNP
rs141837157 1117 dbSNP
rs1192854505 1118 dbSNP
rs1264992124 1121 dbSNP
rs1374979054 1125 dbSNP
rs1277423146 1131 dbSNP
rs1030120933 1132 dbSNP
rs910047435 1135 dbSNP
rs1327381591 1138 dbSNP
rs941807206 1139 dbSNP
rs1393720612 1154 dbSNP
rs943330571 1158 dbSNP
rs562105570 1159 dbSNP
rs770501941 1162 dbSNP
rs900189463 1164 dbSNP
rs926003127 1183 dbSNP
rs935842538 1184 dbSNP
rs759715667 1190 dbSNP
rs1254939448 1194 dbSNP
rs1052925090 1198 dbSNP
rs767304599 1204 dbSNP
rs891750363 1205 dbSNP
rs1315530400 1212 dbSNP
rs1292353278 1223 dbSNP
rs1281650780 1224 dbSNP
rs1367319727 1225 dbSNP
rs1222820043 1226 dbSNP
rs1014168189 1240 dbSNP
rs995874909 1241 dbSNP
rs1051399486 1243 dbSNP
rs890384904 1251 dbSNP
rs775207724 1256 dbSNP
rs1290631223 1261 dbSNP
rs1010154979 1272 dbSNP
rs760509166 1273 dbSNP
rs1001586023 1276 dbSNP
rs1020164679 1281 dbSNP
rs764007576 1284 dbSNP
rs962423385 1297 dbSNP
rs1158164122 1298 dbSNP
rs1305589411 1303 dbSNP
rs1397189819 1315 dbSNP
rs995000313 1316 dbSNP
rs753779963 1317 dbSNP
rs1000712512 1328 dbSNP
rs191173935 1329 dbSNP
rs959015874 1330 dbSNP
rs1205550969 1342 dbSNP
rs150384021 1353 dbSNP
rs138100018 1358 dbSNP
rs912100480 1362 dbSNP
rs1212122395 1365 dbSNP
rs1348153063 1371 dbSNP
rs1282032411 1377 dbSNP
rs1231368542 1390 dbSNP
rs1311131705 1397 dbSNP
rs1295719173 1399 dbSNP
rs764797812 1401 dbSNP
rs867870672 1405 dbSNP
rs1359851893 1407 dbSNP
rs1288066634 1409 dbSNP
rs1415173240 1410 dbSNP
rs975130251 1413 dbSNP
rs1425686293 1415 dbSNP
rs1434143233 1424 dbSNP
rs1373687115 1430 dbSNP
rs1163257255 1444 dbSNP
rs926053681 1448 dbSNP
rs982985995 1462 dbSNP
rs764256512 1470 dbSNP
rs910067943 1472 dbSNP
rs183300655 1473 dbSNP
rs796291033 1474 dbSNP
rs913070631 1480 dbSNP
rs949895909 1482 dbSNP
rs745543456 1499 dbSNP
rs1305626348 1500 dbSNP
rs187677440 1503 dbSNP
rs1407609007 1505 dbSNP
rs1233622971 1521 dbSNP
rs921714961 1533 dbSNP
rs1357168799 1535 dbSNP
rs1001239476 1540 dbSNP
rs562293656 1544 dbSNP
rs531509811 1546 dbSNP
rs1379229472 1548 dbSNP
rs1299965932 1552 dbSNP
rs1460535216 1554 dbSNP
rs548068424 1560 dbSNP
rs1354408507 1573 dbSNP
rs985926927 1575 dbSNP
rs1229574365 1596 dbSNP
rs1476493838 1621 dbSNP
rs1416110411 1638 dbSNP
rs1309987300 1661 dbSNP
rs1358572918 1667 dbSNP
rs750101182 1669 dbSNP
rs1051468156 1671 dbSNP
rs567763621 1672 dbSNP
rs527270648 1673 dbSNP
rs1041618192 1674 dbSNP
rs904416573 1677 dbSNP
rs1214212954 1689 dbSNP
rs1481984283 1691 dbSNP
rs1291199285 1693 dbSNP
rs1000049044 1694 dbSNP
rs1034564073 1703 dbSNP
rs1243879748 1707 dbSNP
rs1336512505 1709 dbSNP
rs149553633 1717 dbSNP
rs1238311122 1718 dbSNP
rs1484378541 1723 dbSNP
rs1014288765 1724 dbSNP
rs1413180392 1727 dbSNP
rs950925712 1728 dbSNP
rs1450566448 1732 dbSNP
rs1171112227 1733 dbSNP
rs1024292302 1739 dbSNP
rs570467720 1752 dbSNP
rs539474003 1754 dbSNP
rs1429563925 1767 dbSNP
rs556490306 1768 dbSNP
rs192124706 1771 dbSNP
rs1237010132 1772 dbSNP
rs1193783535 1775 dbSNP
rs1009456059 1777 dbSNP
rs1019217310 1780 dbSNP
rs1208961972 1780 dbSNP
rs1359336371 1781 dbSNP
rs1017204620 1782 dbSNP
rs573891461 1785 dbSNP
rs975613989 1789 dbSNP
rs921392129 1793 dbSNP
rs931755086 1794 dbSNP
rs536201471 1801 dbSNP
rs987206733 1815 dbSNP
rs556077587 1820 dbSNP
rs1435714565 1822 dbSNP
rs1299799402 1833 dbSNP
rs1339767105 1838 dbSNP
rs1387547317 1840 dbSNP
rs1157214871 1851 dbSNP
rs925939167 1854 dbSNP
rs1379306792 1864 dbSNP
rs72673865 1865 dbSNP
rs1251033539 1868 dbSNP
rs1198122287 1876 dbSNP
rs1279096179 1879 dbSNP
rs1263519085 1881 dbSNP
rs1203170495 1882 dbSNP
rs1353257023 1886 dbSNP
rs1041749738 1895 dbSNP
rs878867641 1905 dbSNP
rs1236563329 1907 dbSNP
rs1314104192 1911 dbSNP
rs1208285530 1921 dbSNP
rs1345870722 1921 dbSNP
rs957317653 1921 dbSNP
rs988909620 1926 dbSNP
rs144239124 1930 dbSNP
rs1359481958 1931 dbSNP
rs879287344 1931 dbSNP
rs981671579 1933 dbSNP
rs927267493 1944 dbSNP
rs185006504 1954 dbSNP
rs1246765698 1955 dbSNP
rs543854876 1958 dbSNP
rs1055672920 1968 dbSNP
rs1475664491 1974 dbSNP
rs1374792131 1975 dbSNP
rs1173465879 1979 dbSNP
rs1427706007 1982 dbSNP
rs894302465 1988 dbSNP
rs1190744060 2001 dbSNP
rs898175594 2003 dbSNP
rs756469521 2016 dbSNP
rs929614257 2019 dbSNP
rs1173593826 2020 dbSNP
rs1484827043 2026 dbSNP
rs1014320017 2027 dbSNP
rs1046816306 2037 dbSNP
rs1024323314 2040 dbSNP
rs1342078235 2042 dbSNP
rs188270278 2056 dbSNP
rs562673409 2065 dbSNP
rs1356545072 2066 dbSNP
rs531399940 2085 dbSNP
rs192608986 2098 dbSNP
rs900790927 2103 dbSNP
rs996432379 2111 dbSNP
rs1410102659 2113 dbSNP
rs962994351 2114 dbSNP
rs1275150974 2115 dbSNP
rs976063051 2134 dbSNP
rs576638737 2135 dbSNP
rs1033226256 2136 dbSNP
rs963266142 2144 dbSNP
rs1028520293 2149 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uacaUCCGGAAAUCUAGugaa 5'
              |||:    :||||    
Target 5' aaugAGGUGGGAGGAUC---- 3'
3 - 19
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000515279.1 | 3UTR | AAAAAUGAGGUGGGAGGAUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000515279.1 | 3UTR | AAAAUGAGGUGGGAGGAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.867 0.17 0.500 0.33 3 Click to see details
HNSC 0.337 0.23 0.071 0.44 7 Click to see details
UCEC 0.199 0.44 0.500 0.33 3 Click to see details
BLCA -0.046 0.49 0.500 0.33 3 Click to see details
BLCA -0.046 0.49 0.500 0.33 3 Click to see details
BLCA -0.046 0.49 0.500 0.33 3 Click to see details
BLCA -0.046 0.49 0.500 0.33 3 Click to see details
BLCA -0.046 0.49 0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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