miRTarBase - #MIRT625533


—
pre-miRNA Information
pre-miRNA hsa-mir-4540   
Genomic Coordinates chr9: 36864254 - 36864308
Description Homo sapiens miR-4540 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4540
Sequence 35| UUAGUCCUGCCUGUAGGUUUA |55
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs937122950 4 dbSNP
rs143699849 7 dbSNP
Putative Targets

Gene Information
Gene Symbol RALGAPB   
Synonyms KIAA1219, RalGAPbeta
Description Ral GTPase activating protein non-catalytic beta subunit
Transcript NM_020336   
Expression
Putative miRNA Targets on RALGAPB
3'UTR of RALGAPB
(miRNA target sites are highlighted)		 
>RALGAPB|NM_020336|3'UTR
   1 ACCACTGAATTTCTAAGACTGTTGAACTCCAGTTTGGGAACTATAACACAGCAGAACAGTTTGATAGGTGATCACTGTAA
  81 AAATAAAAACAAATCACTCCCAAGAGCTTACTGTTTAATCACCAGAATAGAAGAAACACATTATAACCCATTTGATAGAA
 161 GACTTTGGGCTATCTAGTGAAATGGGCTCCCAGACACAATCATACTCCTGCTGATAATGATGATATACATTTTAGCCATA
 241 AACTTTCTTTTAAAAGTGACAATTTTAGTTAAACATAAGCCTTTTGAGGAGAAAGGCTTTTATGCATCTCAGTTAAACAC
 321 GTGCATTGGTAGTATCAACAAATTTGCAATATAGAAGTTGAAGATAGTTTTTTACCTCACTTTTTAGGAGGTTGTATTCA
 401 AAATTAAAATCTCAGAATCTTACAGGACATTTAAAGACTCATGTTGATAGCATGGAGGAGAAGGAAAGAAGTCACAGCCT
 481 TCTACTCAGTTGTAGGTCTTCTTGTCATCCAGCTGTCACACTGACAAAAAGAAAAGATGATACATGTTTTTTGCTCAGAT
 561 AAGAAGCCTGACATTAAAAGATGTCATATTTTTTTCTCCACATTTCAAAAAGTTGTCCTTCTCATCACTGCACAGATCTG
 641 TCTGAAAGCCTCAGTTTCTGAGTGACCCAGGAACAGATCAGAAATGGAGCATGGCCTTGTCCTTTAATGGGGATGCAAAT
 721 AAAGTTTGTGGGGTTAAAAGTTATAAGACAGCAGTGATACCCCACTCTCTCCATTATTGTCCAGCGGGGTGACATAATGA
 801 CAGGTTAAATATTTGTGATTCATTGATTAAATATTATTTAAAGAAATGTAAATTCACAATAAGGGTTGAAAATTATTTGG
 881 TTTCATCCATTGTCTCTTATTTCAGGACCAAGCAGCAAACTGCAGTAGTTTGTGAAGGATTCTAATATGGGGTTCAGGAA
 961 TAGCCTCTCAACGCTACTAATTCAGATCTCTCCCAGAGAACTACTGGATTTCCTCATAATTGACAAACATGAGTGACCAC
1041 CTCTTTGGGTGGCTACTGTTAGAAATGGCTGTTGTCATGTTTTCTGGACTTTGCCAGCCAACAGATCCCTGCCAGGTTTT
1121 GGAAATACTTCTATTACCTCGCTGCTACTTTTCTGCAGGGATAAAACTTTTGAGGTGGCCAGACCCAGAACATCCAAGGA
1201 TTCCTGTTACAGTGCTACAGTATACACTGCTCATTTATCCTATTCTCATGTGCTTTCTTCTTTAGTAAGATTATTTTAAG
1281 AAAATAAGTGATATTTAAAGTCCAAAGAGGAATGATCACAGTTGTATAAGGGGTGTTTTCCCACTTGAACTCTGATGTCA
1361 GTCGACTGTGGGTCAGAGCTACAACCATCTGTTTGGTTTGATGTTTTGGTGGTTTACTTACGGAGTGGGGATAGTGTGAG
1441 ACCTAATTCCCTGTGCAAATGTCTCTTATTCCAGAAATGTGCATTTTGTCATCTATAAGCAAGAAATATGGGCATAGCAG
1521 CTCTTGGTTTAAAGTTTGCCATAACCTGTTCATGTTTGTTTTAAGCTCAGGTAAAGATAACCTCCTCTTTCTATGACTCC
1601 AGTTTCCATTCAGGTTATAGTATTATTCAATAGTTGATTTTCTTTTTAAGCTGGGCAATAAATTGATGTTTCCAGATGGT
1681 AACATGGGAGAGGGCATATAGGATAAAGATGAGCAAATTCTACCCTAAAAATGTTCTAGTAGTTCACAGGAAGAAGATGA
1761 GGTTTAATAACTTTCAAGGTAATTCTAGATTGACATTTTGAGGGGAAAATGGGCTCTTGTTCTAGTTGAAGTGAGCAGAG
1841 AAGGCTATAAATTAATATGTAACTTACAGCATTCCAGAGGTTAAAAATAACTGATGCAGATGTACTTCTTCAGTGTGATT
1921 CTTCAGATCAAACTTTTACTTTTGGCATAGTTAATTTCAGAAAAATGTGCTGTATGTGTGTGTGTATGAGGGTTGGTCTT
2001 GCTGATCCTTCAGTTAGCTCTAAATTCTGGCAACTCCTTGTAATTCCAATGTATTTGATACATGAACAATCATGTTGAAT
2081 GCATTTGTGATCTGGGAGACTTCCTCGTCTTCCAGGGAAGGAAGGATGTGCAGCCCCTGAAGGCATGAAACTCCCAGTGT
2161 GTACGGAGCCAGTGGAATATGGGATACCCATACCTTACCAGGCGCTGGTTCCTTCTGCTCACAATAACATCTGCCCAAAG
2241 AGGGAGTGGGAAGAACGCTTAGCTCTTTCACTAGTATGGATTTGAGTTCATGGTCACTATTTTTACCCACCTGCCTTTGT
2321 TAAAAATCACTTTGAGTAGAATAGCACTGGAGGAACATATTTAGCACCTAATATTAATATTTAGTAGTCCATTGATAAAT
2401 TTGCCAGCATATGTTCTAGCCTCTGGGGGGAAACCAGGACCACTTTTGTCTGTGGCTTAAACAGTTCAGTTGCTATATCT
2481 GTTGGGTATGCCGGGGGTGGATGAGTGTGGCATTCCGTGAAGAGGAAGGTGGTAAGTAAGGTTTCCCTTCTACTGCCTTC
2561 TTAAGTTGCAGGAGGGAGCTTTTCTCCTCCCCTCTGGTTGGGAGCACTGAGGACAGTGAGGAGGGCTTTTACCTTGTTAA
2641 TCCTTTCCTTATTTAGCTAGCTTTCCTTTTTGTCTAGGGCTTCCTCTTGAGACCCTCTTCCATCCATTGGGCCTTTGAAA
2721 GGACTAATCAGACACACACACACACACACACACACACACACACACTCGCATACTCATGCACATTTTCCTTCATTTCCAGA
2801 TCCTTTATTTCAGAGCAGCCCATTTTCCTCTGGATTCATTGATGAATACAAGTACCCACACCTTTGGCCAGTAATGTCAG
2881 TTACCTGCTGCAGGTTCTGTGTATGAGGCCTTCATGAACGGTTACCTTCTCCATACACTAGGGAAGCATTTGTCAGACTC
2961 TGCAGACTGGGTTCTAGAGAGGCAGAGTCTTTAAGAGTATTCATTTCTTCTGGAAGGTGGAGCTTTACCCAAAGTGGAAG
3041 TTAGCCTTGCTCAAAGATGTGTTTTGTGGTAGGTGGTAAAAATAAATAAATAAATAAATAATAAAAAAAGAAACATGTAT
3121 TGGAGGTAATTTGACACTGCTGCTGGCAGTAGTTCTCTATTCACCATTTTAAAGCCCATTCAGGTTCTCTCTTCCTGAAA
3201 AGAACTGATTGCTGTGTTTACATGAAATGACATTGGAGTCAGATGGTCTGTTTTAAAGATTTCCATGACAGCCTCTTTTC
3281 CTGAGTTGGAGAGATTGGAGGTGGTCTATCCGTACGATGTGGAATCAAACGGTGGGTTTCTTAGTAGCTAAAGAAGCCAT
3361 GTACTTCTAGTGTGTTTCTCAGAATATCAACTCATGTTCTTCAGATGCTTTTCTTTTTTTAATGGTGAGGGAAAAGGTAT
3441 AATTTGGGATTCCACAGTGCCTTGCATATAGTAGGCGCCCAGTAAATACTTGTTGAAGCAAACCAAGTTTCCCAAGTCCT
3521 CATCTCTTATAGTGACCAAGACATCTTTCTCCTCTGAAGGGCTTGGCAGTTGTGGCTAAAAAATAAGCAGTATCATTATT
3601 TGCTTGAAATCATATATACAGTTTGTATGAATTTCAGTATGTTGCCAAGACATGATTTTTTCTTATTGTATTTTCTGTAA
3681 ATATTTCTGGCACTGAACTGTAAAGTAAAGGCAAAGTGTAAATATGAAGGCGTGCCCGTGCCCCTTGCCTCCTGTGTTTC
3761 ATCTTCGTCGGTTAGGGAAGAAGGTCCAGAGGTTTGTTTGTATTTATGCCGATCCTTTGTCCAGAAGAAGCCCATGGAAT
3841 ATTGAATGTAATACATTTAGTCAATTAAATTTTAAGGAGATTCTTATCTAATAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUGGAUGUCCGUCCUGAUu 5'
            ::||| : |  ||||||| 
Target 5' tgGGCCT-TTGAAAGGACTAa 3'
 2708 - 2727 146.00 -15.80
2 
miRNA  3' auuuggAUGUCC---GUCCUGAUu 5'
                ||::||   ||||| || 
Target 5' ttctaaTATGGGGTTCAGGAATAg 3'
 940 - 963 123.00 -9.10
3 
miRNA  3' auUUGGAUGUCC-------GUCCUGAUu 5'
            |:||| ::||       |||||| | 
Target 5' ctAGCCTCTGGGGGGAAACCAGGACCAc 3'
 2416 - 2443 123.00 -14.73
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26991471 12 COSMIC
COSN30167883 20 COSMIC
COSN26991472 27 COSMIC
COSN30102250 55 COSMIC
COSN28888611 58 COSMIC
COSN28030600 68 COSMIC
COSN31500755 69 COSMIC
COSN30193064 74 COSMIC
COSN30500827 94 COSMIC
COSN31536417 111 COSMIC
COSN31534585 211 COSMIC
COSN32168488 361 COSMIC
COSN17181965 450 COSMIC
COSN15258757 466 COSMIC
COSN30165120 488 COSMIC
COSN31543913 520 COSMIC
COSN31592744 555 COSMIC
COSN19605899 577 COSMIC
COSN31548136 581 COSMIC
COSN31661600 973 COSMIC
COSN31548984 1166 COSMIC
COSN31548139 1246 COSMIC
COSN1871156 1366 COSMIC
COSN20584838 1439 COSMIC
COSN22661199 1469 COSMIC
COSN29026628 1607 COSMIC
COSN22698583 1681 COSMIC
COSN28638030 1719 COSMIC
COSN21456717 1785 COSMIC
COSN26509249 1947 COSMIC
COSN25002564 2181 COSMIC
COSN22411196 2285 COSMIC
COSN25780874 2502 COSMIC
COSN7090776 2592 COSMIC
COSN21318617 2641 COSMIC
COSN20116438 2766 COSMIC
COSN29105888 2766 COSMIC
COSN16458556 2881 COSMIC
COSN28019165 3078 COSMIC
COSN23118584 3083 COSMIC
COSN26241233 3159 COSMIC
COSN10015272 3179 COSMIC
COSN22215051 3203 COSMIC
COSN8610919 3477 COSMIC
COSN31480534 3478 COSMIC
COSN31533439 3546 COSMIC
COSN31536423 3584 COSMIC
COSN31557416 3784 COSMIC
COSN23804217 3788 COSMIC
COSN25879241 3811 COSMIC
COSN31579048 3833 COSMIC
COSN30157921 3863 COSMIC
COSN31520906 3869 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770730608 2 dbSNP
rs778765832 10 dbSNP
rs771958071 13 dbSNP
rs1464473302 16 dbSNP
rs1218179016 17 dbSNP
rs775559658 19 dbSNP
rs751713519 30 dbSNP
rs1465460651 33 dbSNP
rs1004515269 36 dbSNP
rs768825220 39 dbSNP
rs1015978778 40 dbSNP
rs1376236768 42 dbSNP
rs1479239494 44 dbSNP
rs776879592 48 dbSNP
rs762130495 50 dbSNP
rs1455172130 52 dbSNP
rs1160661185 61 dbSNP
rs765654219 62 dbSNP
rs1172608166 63 dbSNP
rs140477117 67 dbSNP
rs1192802991 77 dbSNP
rs1307802116 93 dbSNP
rs45603931 98 dbSNP
rs895784792 103 dbSNP
rs1010456487 106 dbSNP
rs1271990673 107 dbSNP
rs1482715641 112 dbSNP
rs562585884 113 dbSNP
rs533126137 127 dbSNP
rs1222553956 128 dbSNP
rs1228932922 151 dbSNP
rs781739089 155 dbSNP
rs1479285855 156 dbSNP
rs545192083 166 dbSNP
rs1217272293 170 dbSNP
rs560314817 173 dbSNP
rs989436499 179 dbSNP
rs746294806 191 dbSNP
rs990827 204 dbSNP
rs192310800 211 dbSNP
rs1399579374 220 dbSNP
rs922726527 221 dbSNP
rs1476763041 226 dbSNP
rs1429397547 227 dbSNP
rs951000280 238 dbSNP
rs934111540 244 dbSNP
rs1303837709 248 dbSNP
rs982715681 259 dbSNP
rs1351748326 263 dbSNP
rs1047233742 269 dbSNP
rs909786643 273 dbSNP
rs1434420453 276 dbSNP
rs1337570996 280 dbSNP
rs887348440 294 dbSNP
rs1362610363 298 dbSNP
rs567245712 303 dbSNP
rs1339037750 305 dbSNP
rs1309453369 313 dbSNP
rs138578211 318 dbSNP
rs1340980881 319 dbSNP
rs1376262256 321 dbSNP
rs780454484 322 dbSNP
rs12986 330 dbSNP
rs941618708 334 dbSNP
rs1291382352 343 dbSNP
rs1396555311 347 dbSNP
rs749648655 353 dbSNP
rs768336960 357 dbSNP
rs773969601 366 dbSNP
rs1011939824 367 dbSNP
rs745764633 368 dbSNP
rs1439914310 387 dbSNP
rs1057112837 391 dbSNP
rs1023766962 395 dbSNP
rs1291266031 410 dbSNP
rs866723727 414 dbSNP
rs906291539 415 dbSNP
rs529606432 420 dbSNP
rs7275066 423 dbSNP
rs879323312 424 dbSNP
rs1353243075 430 dbSNP
rs1307224157 438 dbSNP
rs899967757 441 dbSNP
rs1371756751 447 dbSNP
rs1324137124 448 dbSNP
rs997948631 452 dbSNP
rs1388387790 455 dbSNP
rs1449079368 475 dbSNP
rs989384277 488 dbSNP
rs569384383 495 dbSNP
rs1379275088 496 dbSNP
rs1156420742 497 dbSNP
rs951052252 500 dbSNP
rs982435910 502 dbSNP
rs1295941887 512 dbSNP
rs1198782531 513 dbSNP
rs1017303906 516 dbSNP
rs1264369151 520 dbSNP
rs1217764837 521 dbSNP
rs771439561 522 dbSNP
rs1284174364 526 dbSNP
rs1389011913 526 dbSNP
rs377689300 526 dbSNP
rs1274326702 532 dbSNP
rs1232511616 543 dbSNP
rs1322997099 546 dbSNP
rs926487453 556 dbSNP
rs939161937 559 dbSNP
rs149350177 561 dbSNP
rs1359610675 564 dbSNP
rs1295982130 569 dbSNP
rs1318288862 571 dbSNP
rs917320788 582 dbSNP
rs148093788 587 dbSNP
rs1375314641 589 dbSNP
rs546270847 589 dbSNP
rs922641221 589 dbSNP
rs760467323 599 dbSNP
rs1353854184 607 dbSNP
rs983350751 609 dbSNP
rs1284397593 610 dbSNP
rs1330427654 618 dbSNP
rs908739718 622 dbSNP
rs766419744 624 dbSNP
rs1211189866 633 dbSNP
rs941523751 636 dbSNP
rs1246743044 637 dbSNP
rs1341516271 641 dbSNP
rs1280047360 656 dbSNP
rs1053979 659 dbSNP
rs1219109144 665 dbSNP
rs900021522 668 dbSNP
rs1038608846 679 dbSNP
rs1276065300 685 dbSNP
rs1416307831 690 dbSNP
rs894735061 698 dbSNP
rs753730165 700 dbSNP
rs947669563 714 dbSNP
rs1029451640 717 dbSNP
rs759386779 720 dbSNP
rs1397937981 733 dbSNP
rs879736443 742 dbSNP
rs1471960114 745 dbSNP
rs1477775963 745 dbSNP
rs906274086 755 dbSNP
rs1004329900 758 dbSNP
rs1162708120 765 dbSNP
rs1412879602 772 dbSNP
rs1458734297 774 dbSNP
rs764436188 780 dbSNP
rs1003317015 784 dbSNP
rs1439650205 790 dbSNP
rs1470085643 792 dbSNP
rs1335993479 798 dbSNP
rs1199267925 803 dbSNP
rs1338307284 805 dbSNP
rs962661342 810 dbSNP
rs980729774 812 dbSNP
rs1052683445 825 dbSNP
rs539660784 826 dbSNP
rs569083251 834 dbSNP
rs1379560609 836 dbSNP
rs960556397 838 dbSNP
rs1010710296 845 dbSNP
rs566626566 848 dbSNP
rs1351737156 850 dbSNP
rs991946656 860 dbSNP
rs1022129315 865 dbSNP
rs1406344136 866 dbSNP
rs1413457925 871 dbSNP
rs963937618 881 dbSNP
rs568772918 887 dbSNP
rs1471278154 892 dbSNP
rs917373094 892 dbSNP
rs183426669 901 dbSNP
rs977877985 914 dbSNP
rs1457294636 925 dbSNP
rs925990175 936 dbSNP
rs187146386 944 dbSNP
rs1029702343 949 dbSNP
rs573972034 951 dbSNP
rs982859605 955 dbSNP
rs1440905328 964 dbSNP
rs1288873848 966 dbSNP
rs908646967 968 dbSNP
rs1187175968 970 dbSNP
rs867387585 972 dbSNP
rs974249342 973 dbSNP
rs934186115 974 dbSNP
rs1445439783 977 dbSNP
rs1180143302 988 dbSNP
rs1295820491 999 dbSNP
rs544205292 1008 dbSNP
rs887239512 1013 dbSNP
rs1163106729 1021 dbSNP
rs1402710132 1037 dbSNP
rs1411074069 1038 dbSNP
rs1003979217 1044 dbSNP
rs376710775 1049 dbSNP
rs757364411 1050 dbSNP
rs1466527348 1052 dbSNP
rs1174104520 1056 dbSNP
rs1399878037 1060 dbSNP
rs1396894040 1065 dbSNP
rs1038503237 1070 dbSNP
rs556439536 1072 dbSNP
rs1192917402 1076 dbSNP
rs1488759113 1077 dbSNP
rs1413716766 1078 dbSNP
rs1219068049 1097 dbSNP
rs1489124411 1101 dbSNP
rs1308191375 1103 dbSNP
rs781076693 1108 dbSNP
rs1238904215 1110 dbSNP
rs1002263062 1114 dbSNP
rs1302765502 1116 dbSNP
rs1220370729 1117 dbSNP
rs1367491224 1118 dbSNP
rs577980345 1119 dbSNP
rs1045109010 1125 dbSNP
rs73611724 1130 dbSNP
rs960611669 1132 dbSNP
rs191126950 1134 dbSNP
rs560351606 1136 dbSNP
rs939026280 1141 dbSNP
rs1176852095 1142 dbSNP
rs1052165572 1143 dbSNP
rs1020754484 1159 dbSNP
rs966917387 1160 dbSNP
rs892215959 1161 dbSNP
rs1215529168 1162 dbSNP
rs1487096665 1165 dbSNP
rs1350374964 1171 dbSNP
rs1234688375 1178 dbSNP
rs141343221 1179 dbSNP
rs1210175078 1183 dbSNP
rs1311065753 1188 dbSNP
rs1299849710 1190 dbSNP
rs1220928163 1193 dbSNP
rs1341592719 1200 dbSNP
rs1277944412 1204 dbSNP
rs957423321 1210 dbSNP
rs1043573555 1211 dbSNP
rs1303603776 1216 dbSNP
rs1465626133 1220 dbSNP
rs182641601 1222 dbSNP
rs150808101 1233 dbSNP
rs934238578 1240 dbSNP
rs1424148860 1243 dbSNP
rs531321451 1255 dbSNP
rs549477496 1257 dbSNP
rs544522788 1263 dbSNP
rs908726823 1269 dbSNP
rs1275568679 1277 dbSNP
rs1484170642 1285 dbSNP
rs1030007662 1288 dbSNP
rs756680992 1290 dbSNP
rs1201133460 1295 dbSNP
rs898230258 1300 dbSNP
rs1001918605 1306 dbSNP
rs1217218522 1322 dbSNP
rs1342584847 1326 dbSNP
rs1433693975 1327 dbSNP
rs1313716227 1329 dbSNP
rs1395604673 1330 dbSNP
rs1004623944 1344 dbSNP
rs1377157079 1346 dbSNP
rs1054723927 1351 dbSNP
rs780507332 1356 dbSNP
rs1400909730 1360 dbSNP
rs896123584 1361 dbSNP
rs1460298980 1364 dbSNP
rs1015655139 1365 dbSNP
rs1165122582 1376 dbSNP
rs1422863290 1377 dbSNP
rs1013471550 1382 dbSNP
rs1375865023 1385 dbSNP
rs962823421 1388 dbSNP
rs974237924 1396 dbSNP
rs1477551147 1401 dbSNP
rs1358915233 1409 dbSNP
rs754402690 1422 dbSNP
rs1020805076 1423 dbSNP
rs1320118487 1424 dbSNP
rs1311612972 1426 dbSNP
rs966593478 1434 dbSNP
rs6070658 1444 dbSNP
rs1489528005 1447 dbSNP
rs34639404 1449 dbSNP
rs1001094712 1452 dbSNP
rs970701362 1453 dbSNP
rs563218496 1454 dbSNP
rs1389598654 1457 dbSNP
rs1033133574 1459 dbSNP
rs1293871663 1460 dbSNP
rs1457126474 1462 dbSNP
rs533399180 1467 dbSNP
rs1160031122 1481 dbSNP
rs575439207 1482 dbSNP
rs1379081355 1484 dbSNP
rs1180372253 1486 dbSNP
rs1306865433 1488 dbSNP
rs938988809 1491 dbSNP
rs1052057849 1492 dbSNP
rs1390900551 1494 dbSNP
rs1268556474 1496 dbSNP
rs138072958 1496 dbSNP
rs946507712 1498 dbSNP
rs1288458823 1504 dbSNP
rs975460787 1507 dbSNP
rs1043521145 1509 dbSNP
rs899648347 1510 dbSNP
rs1191667810 1518 dbSNP
rs1236849341 1528 dbSNP
rs1332723463 1532 dbSNP
rs1301841811 1536 dbSNP
rs987072396 1542 dbSNP
rs1344582707 1545 dbSNP
rs749700028 1547 dbSNP
rs1226543825 1553 dbSNP
rs1419926039 1570 dbSNP
rs11699115 1571 dbSNP
rs932496969 1577 dbSNP
rs879541436 1590 dbSNP
rs1050987689 1594 dbSNP
rs891046048 1596 dbSNP
rs1004211690 1597 dbSNP
rs1378754806 1600 dbSNP
rs1198722363 1603 dbSNP
rs755473653 1604 dbSNP
rs1488812311 1607 dbSNP
rs1265714525 1616 dbSNP
rs937766753 1632 dbSNP
rs143632358 1635 dbSNP
rs1265120712 1649 dbSNP
rs1282290665 1651 dbSNP
rs1202275164 1656 dbSNP
rs1275381273 1657 dbSNP
rs1232357062 1673 dbSNP
rs896177355 1674 dbSNP
rs1451018287 1676 dbSNP
rs1188930110 1677 dbSNP
rs1339411328 1680 dbSNP
rs1315741982 1683 dbSNP
rs1402227251 1686 dbSNP
rs1415708480 1686 dbSNP
rs1172512195 1687 dbSNP
rs1468698361 1701 dbSNP
rs534072533 1702 dbSNP
rs1447268895 1710 dbSNP
rs1167507095 1711 dbSNP
rs1368687680 1712 dbSNP
rs1042317151 1713 dbSNP
rs995620929 1715 dbSNP
rs1160970133 1721 dbSNP
rs1023067992 1728 dbSNP
rs1321309655 1731 dbSNP
rs1259797125 1732 dbSNP
rs1219044097 1733 dbSNP
rs1338455309 1733 dbSNP
rs1389172606 1734 dbSNP
rs970226807 1737 dbSNP
rs1340627354 1740 dbSNP
rs1440910626 1746 dbSNP
rs982018275 1754 dbSNP
rs900303370 1758 dbSNP
rs1465445169 1759 dbSNP
rs1417731294 1764 dbSNP
rs1367727040 1766 dbSNP
rs549431968 1771 dbSNP
rs1035910208 1772 dbSNP
rs956523746 1773 dbSNP
rs987764047 1776 dbSNP
rs1473240883 1778 dbSNP
rs1237027806 1786 dbSNP
rs1181798891 1800 dbSNP
rs1239964141 1803 dbSNP
rs1199134677 1814 dbSNP
rs1306715480 1817 dbSNP
rs866423326 1817 dbSNP
rs1270621699 1820 dbSNP
rs1295076599 1826 dbSNP
rs1322577268 1828 dbSNP
rs1356570660 1834 dbSNP
rs147158830 1844 dbSNP
rs113666694 1845 dbSNP
rs946455371 1848 dbSNP
rs955387443 1849 dbSNP
rs1263800544 1850 dbSNP
rs1332635400 1851 dbSNP
rs778564876 1856 dbSNP
rs921017230 1858 dbSNP
rs1325916379 1860 dbSNP
rs187065477 1863 dbSNP
rs542046867 1866 dbSNP
rs1413384808 1867 dbSNP
rs538262405 1868 dbSNP
rs1463325351 1869 dbSNP
rs1051406374 1880 dbSNP
rs920101954 1888 dbSNP
rs1187728484 1890 dbSNP
rs771621675 1893 dbSNP
rs1380930163 1895 dbSNP
rs73294769 1898 dbSNP
rs1480262648 1908 dbSNP
rs140416478 1909 dbSNP
rs760206325 1910 dbSNP
rs917654701 1919 dbSNP
rs1223531560 1925 dbSNP
rs1184736620 1928 dbSNP
rs939945705 1930 dbSNP
rs758008443 1934 dbSNP
rs1457325148 1939 dbSNP
rs1042035451 1941 dbSNP
rs1160475075 1946 dbSNP
rs1391514755 1947 dbSNP
rs1037022504 1948 dbSNP
rs764301799 1948 dbSNP
rs936597182 1950 dbSNP
rs1277079819 1951 dbSNP
rs544195301 1953 dbSNP
rs1365278733 1961 dbSNP
rs1421752795 1973 dbSNP
rs762117127 1973 dbSNP
rs1380122950 1975 dbSNP
rs777442347 1975 dbSNP
rs554056945 1977 dbSNP
rs995524274 1993 dbSNP
rs573245830 2006 dbSNP
rs905948848 2017 dbSNP
rs1405729054 2028 dbSNP
rs776664367 2035 dbSNP
rs1424160999 2038 dbSNP
rs1003035684 2049 dbSNP
rs759438095 2050 dbSNP
rs191117002 2051 dbSNP
rs1229090705 2055 dbSNP
rs1219870459 2072 dbSNP
rs989050663 2074 dbSNP
rs1489053300 2081 dbSNP
rs774648037 2082 dbSNP
rs182208564 2090 dbSNP
rs1214778033 2094 dbSNP
rs576026977 2108 dbSNP
rs139677654 2116 dbSNP
rs1016019748 2120 dbSNP
rs1281759420 2125 dbSNP
rs543406789 2136 dbSNP
rs1341393144 2137 dbSNP
rs1255058480 2143 dbSNP
rs979075602 2144 dbSNP
rs1183745924 2154 dbSNP
rs1360897030 2161 dbSNP
rs540656109 2165 dbSNP
rs767775550 2172 dbSNP
rs1158831898 2173 dbSNP
rs564499391 2174 dbSNP
rs986634876 2179 dbSNP
rs765478616 2184 dbSNP
rs1360165301 2188 dbSNP
rs750508253 2189 dbSNP
rs533483939 2194 dbSNP
rs912415009 2204 dbSNP
rs990942630 2205 dbSNP
rs1238699938 2208 dbSNP
rs116023190 2219 dbSNP
rs1323429519 2221 dbSNP
rs1261708852 2225 dbSNP
rs756163800 2232 dbSNP
rs1301247594 2236 dbSNP
rs1220869649 2237 dbSNP
rs770894627 2244 dbSNP
rs555453679 2251 dbSNP
rs1318962536 2254 dbSNP
rs1036924799 2257 dbSNP
rs1380737497 2260 dbSNP
rs1381502926 2275 dbSNP
rs766891599 2278 dbSNP
rs6070663 2283 dbSNP
rs1290343242 2287 dbSNP
rs1405301289 2298 dbSNP
rs1044823207 2299 dbSNP
rs936330516 2301 dbSNP
rs1348518260 2330 dbSNP
rs1467003945 2342 dbSNP
rs1373368410 2347 dbSNP
rs1054141304 2355 dbSNP
rs921838148 2357 dbSNP
rs1223213098 2359 dbSNP
rs1415398830 2360 dbSNP
rs905944553 2369 dbSNP
rs1460443307 2370 dbSNP
rs1051598773 2378 dbSNP
rs868851087 2379 dbSNP
rs1301915073 2387 dbSNP
rs1313669591 2390 dbSNP
rs1458542931 2392 dbSNP
rs1251093604 2397 dbSNP
rs1003393121 2402 dbSNP
rs890260582 2408 dbSNP
rs1323698734 2422 dbSNP
rs149700610 2425 dbSNP
rs1380600825 2433 dbSNP
rs1334617814 2438 dbSNP
rs891935642 2440 dbSNP
rs1279109014 2443 dbSNP
rs549285927 2444 dbSNP
rs755338051 2446 dbSNP
rs1297375242 2456 dbSNP
rs1021799070 2476 dbSNP
rs897172078 2478 dbSNP
rs995509054 2484 dbSNP
rs76296809 2486 dbSNP
rs959615342 2487 dbSNP
rs779086236 2489 dbSNP
rs879675388 2491 dbSNP
rs188757062 2493 dbSNP
rs970844479 2493 dbSNP
rs748527840 2494 dbSNP
rs758030834 2506 dbSNP
rs1489642755 2511 dbSNP
rs144441007 2512 dbSNP
rs923698444 2517 dbSNP
rs78668031 2518 dbSNP
rs1357461835 2520 dbSNP
rs961159231 2528 dbSNP
rs148413815 2547 dbSNP
rs1336252201 2554 dbSNP
rs1306155585 2561 dbSNP
rs1389471668 2570 dbSNP
rs1394677074 2571 dbSNP
rs1430686400 2575 dbSNP
rs919831633 2579 dbSNP
rs1423587291 2589 dbSNP
rs1309926782 2595 dbSNP
rs921558802 2595 dbSNP
rs1368725442 2602 dbSNP
rs554094920 2605 dbSNP
rs572336511 2606 dbSNP
rs1441573731 2608 dbSNP
rs536467704 2617 dbSNP
rs1180213898 2634 dbSNP
rs1435282568 2636 dbSNP
rs34662847 2638 dbSNP
rs931257777 2644 dbSNP
rs1294003792 2649 dbSNP
rs1044383752 2673 dbSNP
rs150221333 2678 dbSNP
rs927313251 2680 dbSNP
rs1288302490 2682 dbSNP
rs1217243424 2683 dbSNP
rs1302463654 2690 dbSNP
rs1260075427 2698 dbSNP
rs1332667187 2708 dbSNP
rs1283656999 2713 dbSNP
rs938709246 2723 dbSNP
rs1343286124 2729 dbSNP
rs1383531628 2730 dbSNP
rs1400795916 2730 dbSNP
rs1222695158 2732 dbSNP
rs1279705283 2732 dbSNP
rs1288627419 2732 dbSNP
rs1315589356 2732 dbSNP
rs1321078802 2732 dbSNP
rs1325407599 2732 dbSNP
rs1398349394 2732 dbSNP
rs1431009824 2732 dbSNP
rs397793591 2732 dbSNP
rs56716236 2732 dbSNP
rs879134422 2732 dbSNP
rs72426341 2734 dbSNP
rs1342429326 2735 dbSNP
rs1336595689 2736 dbSNP
rs1468584064 2738 dbSNP
rs1426223218 2748 dbSNP
rs1230237135 2749 dbSNP
rs940516893 2750 dbSNP
rs1037553777 2758 dbSNP
rs1461787571 2760 dbSNP
rs554420413 2760 dbSNP
rs1459865584 2761 dbSNP
rs1306345286 2762 dbSNP
rs891890131 2762 dbSNP
rs1214847750 2763 dbSNP
rs528205855 2763 dbSNP
rs1247752030 2765 dbSNP
rs995953934 2766 dbSNP
rs367964677 2767 dbSNP
rs1010353444 2768 dbSNP
rs1043245341 2769 dbSNP
rs1329924422 2770 dbSNP
rs576096699 2771 dbSNP
rs1170648803 2772 dbSNP
rs895120281 2777 dbSNP
rs904767843 2779 dbSNP
rs1445319509 2782 dbSNP
rs543142296 2783 dbSNP
rs1029261250 2793 dbSNP
rs1234437813 2801 dbSNP
rs1025161367 2804 dbSNP
rs970897139 2809 dbSNP
rs111617794 2810 dbSNP
rs1031207558 2812 dbSNP
rs1007894903 2823 dbSNP
rs1019745973 2828 dbSNP
rs957813522 2842 dbSNP
rs1313703377 2848 dbSNP
rs961147708 2851 dbSNP
rs989600448 2876 dbSNP
rs746542554 2880 dbSNP
rs1434301965 2881 dbSNP
rs1324959136 2890 dbSNP
rs1305259168 2891 dbSNP
rs373890716 2902 dbSNP
rs1365091130 2903 dbSNP
rs6026624 2908 dbSNP
rs545326790 2915 dbSNP
rs919780927 2920 dbSNP
rs952593874 2921 dbSNP
rs1410103264 2922 dbSNP
rs980396476 2930 dbSNP
rs927249832 2932 dbSNP
rs770526920 2934 dbSNP
rs193292819 2938 dbSNP
rs992877873 2939 dbSNP
rs1230945281 2940 dbSNP
rs527934198 2943 dbSNP
rs45462801 2945 dbSNP
rs1490401714 2947 dbSNP
rs1291447714 2954 dbSNP
rs1290529114 2958 dbSNP
rs561317945 2958 dbSNP
rs911799606 2965 dbSNP
rs370144417 2967 dbSNP
rs946159396 2968 dbSNP
rs1285579896 2971 dbSNP
rs1043195576 2978 dbSNP
rs904672385 2989 dbSNP
rs376774570 2996 dbSNP
rs1051074204 2998 dbSNP
rs1285559133 3009 dbSNP
rs890720487 3012 dbSNP
rs745744050 3017 dbSNP
rs971922295 3018 dbSNP
rs1345152270 3038 dbSNP
rs1301476159 3053 dbSNP
rs920386522 3060 dbSNP
rs1345797963 3062 dbSNP
rs115069585 3064 dbSNP
rs10557 3067 dbSNP
rs550277376 3068 dbSNP
rs1405566442 3073 dbSNP
rs993946937 3076 dbSNP
rs142212962 3080 dbSNP
rs563534361 3080 dbSNP
rs948041710 3080 dbSNP
rs1196751028 3086 dbSNP
rs1046222 3088 dbSNP
rs1046223 3092 dbSNP
rs1240556972 3095 dbSNP
rs1046661782 3097 dbSNP
rs201162898 3097 dbSNP
rs1315624133 3100 dbSNP
rs199823081 3100 dbSNP
rs1000146833 3103 dbSNP
rs1265501292 3103 dbSNP
rs1323205423 3103 dbSNP
rs1026747470 3104 dbSNP
rs1216531844 3105 dbSNP
rs1428668358 3107 dbSNP
rs151118207 3107 dbSNP
rs1459956585 3108 dbSNP
rs141336415 3111 dbSNP
rs1034673533 3115 dbSNP
rs1338548999 3117 dbSNP
rs1428321664 3125 dbSNP
rs960023247 3127 dbSNP
rs1010675017 3136 dbSNP
rs1429895554 3137 dbSNP
rs185104482 3143 dbSNP
rs1185452473 3159 dbSNP
rs538040257 3160 dbSNP
rs1204799477 3164 dbSNP
rs1318350164 3164 dbSNP
rs536116530 3176 dbSNP
rs1461188779 3182 dbSNP
rs946066307 3185 dbSNP
rs554789430 3190 dbSNP
rs1295078418 3201 dbSNP
rs1448382965 3206 dbSNP
rs1285432216 3211 dbSNP
rs961992131 3214 dbSNP
rs1376268667 3222 dbSNP
rs530728328 3223 dbSNP
rs1453282466 3233 dbSNP
rs190349038 3234 dbSNP
rs1300840923 3236 dbSNP
rs1463286262 3243 dbSNP
rs1354783658 3249 dbSNP
rs1050648297 3251 dbSNP
rs890697129 3254 dbSNP
rs930453649 3265 dbSNP
rs1330486923 3281 dbSNP
rs1210937891 3287 dbSNP
rs984196754 3294 dbSNP
rs916654748 3298 dbSNP
rs6026626 3302 dbSNP
rs537174962 3304 dbSNP
rs767680195 3307 dbSNP
rs1241789591 3308 dbSNP
rs1040719110 3309 dbSNP
rs896795952 3312 dbSNP
rs906491882 3313 dbSNP
rs993851871 3316 dbSNP
rs773433809 3317 dbSNP
rs1246684403 3320 dbSNP
rs1053093172 3326 dbSNP
rs888237740 3329 dbSNP
rs1412587844 3331 dbSNP
rs867674487 3341 dbSNP
rs1373712526 3351 dbSNP
rs558213638 3357 dbSNP
rs576493759 3360 dbSNP
rs540630698 3375 dbSNP
rs893998526 3380 dbSNP
rs1011066435 3382 dbSNP
rs1163696260 3384 dbSNP
rs192947033 3391 dbSNP
rs564248719 3394 dbSNP
rs1384047195 3396 dbSNP
rs1367244572 3420 dbSNP
rs1184530650 3424 dbSNP
rs1414836687 3431 dbSNP
rs528160838 3435 dbSNP
rs373996082 3440 dbSNP
rs1180342584 3446 dbSNP
rs1490895793 3450 dbSNP
rs1018622189 3467 dbSNP
rs961987922 3470 dbSNP
rs1357286265 3471 dbSNP
rs761917249 3472 dbSNP
rs542951317 3477 dbSNP
rs1241080063 3478 dbSNP
rs1027970729 3493 dbSNP
rs951943972 3494 dbSNP
rs1351643685 3500 dbSNP
rs1347047580 3511 dbSNP
rs1230837746 3520 dbSNP
rs1278311931 3524 dbSNP
rs372523842 3525 dbSNP
rs967313302 3531 dbSNP
rs978737599 3542 dbSNP
rs1280937869 3550 dbSNP
rs1157429797 3552 dbSNP
rs969453366 3556 dbSNP
rs1269872671 3562 dbSNP
rs184035413 3570 dbSNP
rs531797576 3579 dbSNP
rs1449995883 3591 dbSNP
rs143815160 3593 dbSNP
rs565401787 3597 dbSNP
rs146857568 3599 dbSNP
rs1252714582 3612 dbSNP
rs1486138595 3612 dbSNP
rs986683278 3615 dbSNP
rs1267386933 3617 dbSNP
rs935311821 3618 dbSNP
rs766377682 3625 dbSNP
rs1325351340 3630 dbSNP
rs1283594480 3632 dbSNP
rs1179496312 3633 dbSNP
rs547820116 3635 dbSNP
rs1328892678 3638 dbSNP
rs1363160191 3645 dbSNP
rs1319693043 3649 dbSNP
rs754353496 3653 dbSNP
rs1384910813 3654 dbSNP
rs755533829 3659 dbSNP
rs946908814 3662 dbSNP
rs1392844944 3663 dbSNP
rs1433787715 3666 dbSNP
rs944882228 3667 dbSNP
rs1308101278 3669 dbSNP
rs1371810658 3671 dbSNP
rs1389184794 3674 dbSNP
rs1374906900 3682 dbSNP
rs1194015143 3687 dbSNP
rs188718971 3694 dbSNP
rs889255568 3700 dbSNP
rs1206730567 3710 dbSNP
rs1008666806 3713 dbSNP
rs1036591348 3727 dbSNP
rs1263494708 3729 dbSNP
rs1335706310 3732 dbSNP
rs1342468395 3733 dbSNP
rs1437599771 3734 dbSNP
rs781548765 3738 dbSNP
rs1040507212 3739 dbSNP
rs1277010440 3742 dbSNP
rs78701458 3746 dbSNP
rs897517822 3747 dbSNP
rs74319829 3748 dbSNP
rs1413071470 3756 dbSNP
rs1398917895 3760 dbSNP
rs530049262 3767 dbSNP
rs1475161562 3768 dbSNP
rs567988192 3770 dbSNP
rs1275635944 3771 dbSNP
rs74494035 3772 dbSNP
rs765766536 3775 dbSNP
rs1446350503 3780 dbSNP
rs1243627922 3783 dbSNP
rs1186617352 3786 dbSNP
rs1001321232 3796 dbSNP
rs35692328 3796 dbSNP
rs1194174888 3807 dbSNP
rs11636 3809 dbSNP
rs1249705645 3810 dbSNP
rs370426969 3811 dbSNP
rs180688037 3812 dbSNP
rs1014046866 3815 dbSNP
rs1020126170 3827 dbSNP
rs967299988 3830 dbSNP
rs185503366 3834 dbSNP
rs1250975174 3840 dbSNP
rs1000148840 3855 dbSNP
rs1329876101 3857 dbSNP
rs1409576451 3865 dbSNP
rs1033035178 3866 dbSNP
rs1368848027 3879 dbSNP
rs928026101 3884 dbSNP
rs1391666634 3886 dbSNP
rs1425337044 3887 dbSNP
rs956764905 3888 dbSNP
rs953572725 3889 dbSNP
rs1471720354 3891 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000397038.1 | 3UTR | AUCAGACACACACACACACACACACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000397038.1 | 3UTR | GAAAGGACUAAUCAGACACACACACACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000397038.1 | 3UTR | AUCAGACACACACACACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4540 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT154897 GNAS GNAS complex locus 2 2
MIRT444915 PSG11 pregnancy specific beta-1-glycoprotein 11 2 2
MIRT446718 PSG3 pregnancy specific beta-1-glycoprotein 3 2 2
MIRT464587 UBN2 ubinuclein 2 2 2
MIRT468816 RSRC2 arginine and serine rich coiled-coil 2 2 6
MIRT469397 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT491901 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT498959 ORC4 origin recognition complex subunit 4 2 8
MIRT499438 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT506234 PEX13 peroxisomal biogenesis factor 13 2 4
MIRT527911 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT532624 PHF5A PHD finger protein 5A 2 2
MIRT538103 DDX6 DEAD-box helicase 6 2 2
MIRT549032 CASZ1 castor zinc finger 1 2 2
MIRT559870 ATXN3 ataxin 3 2 2
MIRT575888 Ablim1 actin-binding LIM protein 1 2 4
MIRT608663 ABLIM1 actin binding LIM protein 1 2 5
MIRT616515 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT624063 EID1 EP300 interacting inhibitor of differentiation 1 2 2
MIRT625533 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 2
MIRT637169 TMEM50A transmembrane protein 50A 2 2
MIRT639274 KLHL23 kelch like family member 23 2 2
MIRT642924 CCDC90B coiled-coil domain containing 90B 2 2
MIRT649085 FBXO25 F-box protein 25 2 2
MIRT655089 PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2 2
MIRT700888 PER2 period circadian clock 2 2 2
MIRT705966 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT709418 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT723921 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4540 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-miR-4540 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-4540 Platinum 23939 resistant tissue (non-small cell lung cancer)

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