miRTarBase - #MIRT626034


—
pre-miRNA Information
pre-miRNA hsa-mir-516b-1   
Genomic Coordinates chr19: 53736845 - 53736934
Synonyms MIRN516-4, MIRN516B-1, MIRN516B1, MIR516B1
Description Homo sapiens miR-516b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-516b-2   
Genomic Coordinates chr19: 53725442 - 53725526
Synonyms MIRN516-3, MIRN516B-2, MIRN516B2, MIR516B2
Description Homo sapiens miR-516b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-516b-3p
Sequence 56| UGCUUCCUUUCAGAGGGU |73
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413434631 1 dbSNP
rs746170707 2 dbSNP
rs1312744198 2 dbSNP
rs752101959 3 dbSNP
rs770077784 4 dbSNP
rs1193425541 6 dbSNP
rs953142850 7 dbSNP
rs1020245150 7 dbSNP
rs775845942 11 dbSNP
rs1402471980 11 dbSNP
rs760158839 15 dbSNP
rs78861479 16 dbSNP
rs765933705 16 dbSNP
Putative Targets

Gene Information
Gene Symbol AREL1   
Synonyms FIEL1, KIAA0317
Description apoptosis resistant E3 ubiquitin protein ligase 1
Transcript NM_001039479   
Expression
Putative miRNA Targets on AREL1
3'UTR of AREL1
(miRNA target sites are highlighted)		 
>AREL1|NM_001039479|3'UTR
   1 CCACTCTCCTGTCATCCAGTTGGCTCCCATGCTCTCTGGAGCTTCTGGGCGCAAGTTACAGACATCATAACCACTGATCC
  81 TAACACACATAACCATCAGCCAGAAGATGCCGCATGCTCCCCTGTGTCTGGAGGATTTTGTCACCTACAAGCCTTGTCTT
 161 TACCTCACCTGCTCCCTGCCCATATCTACCACAGGCCACTTTGGCATGGTATGTAAGCTGAGCTCTTCATTCTGTCATGA
 241 GAAGAGGACCATGCTGCTATCATTTATTTGGTCCTTTGAAGATCTCAGTAGCTGAGGGAGATGGCACACGGGGCTCAGCC
 321 CTGTTGGGAAACTGGTGTGGAGACCCTTAAATCCACACTGTGCTCCAAAACTCCCTCTGCTGATACTCCTTGGAGACACC
 401 CTCTTTGGCCCTCACTACTTGACCAGACTGGTACTTGAGTCCTTCTCATGGGTGGGGTGATTGCCTCTTCTCATCAGGAG
 481 CCAGGAGAGAGGGGGACAGATAGGAGGTGGCCCATAGGAGCAGTCCCGCTGCACAATGGTAGGCATAGGCCATGGCACTG
 561 GACTGCCTCTAAGGACTGCTAAAAAGAATATTTTTTTGTGGTGTCAGAACTGGAAAAAGCACTTTCCCTTCGGGCATTTC
 641 TGGAAATGATTATTAATCCACAAAGAAGAACTCTGTAAGCTTTTTCTTGAATTGTAGCCAGTGAGAAAAGCAGATAGACT
 721 GAAGAATATGAAGGATAGCTGAGCTGTAGCCTCCAGAGTGGGGCATGCCTAGGCATATGGCTGGCTTGGAGACTACTGAT
 801 GCTTTTCCCTGAGTTTGTTATTGGCACTGAAGTATGGCCGGCTTGGGCCACTGACTTCCCCATTATGTAGTCTGCTAAAA
 881 GCTGGGGATCCTTTAGCATTCTACTGAAGAAAATTTTGTAGCAAAAGATTAGAACAGTAAGAATAGTATGCCAGCAATCC
 961 CTGATTCTCTCTCTGCTTGGTGTTCTCTGGCAGCACTAAGACAAAGGAACAGGGACTAGGAGTTTACGTGCTTATCACAG
1041 GTCCTTGGCGTCAGGACACTAGGGATGAACATGGAGGTGATATGTTACACAGTAAACACCTGCCAACCCCTGTACTCCCC
1121 TTTGCTCCATCAGTTATCAGGAAGGAGAACTAAGGAGGGAGGAAGCTTATTAGGTTCACTGTTGAATGATGATTGAAGAG
1201 TACCTGCTGCTGTATCTTGGAAGATGACAACATCCTTTTTCATTACTGTTTGATTGAAAATAATTTCAAGATTCAAAATC
1281 TCATTGACTTCCCAAATTTGTGTTTTTAAGAAGGCTTTGCTGCAAGCTACCATTCCCAATGGGGCAGTCAACTCTGAGAA
1361 TATTACAAGCCATCTTTATTGCCAAAACCAGCAAGTACACAGAGTCCTGAAACAAGGCAGGACTTTGGCAATGCCTTGGC
1441 CTCCTGGAAGCATGTCTGAGCCCTCCTGTTCGCAGGGATCATGAGGAACAAGCCCTCCTGAGCTGCTACAGTTCCTGCCT
1521 GACCTCAGTCTTTCGCAGTCATCATTTGTCCTTTCTTGGCACATGGGTGCTGACCTCACTCATCCTTGGGGTCCGGGATC
1601 CAGCATCAGGGTCTCTATACCCCAGGATCCTCCATGCCACATGGTCACTGCTCTCCTCAGGGACCAGGACAAGGTGCTGC
1681 TGCTTGCCCAAATGTTTTCCCATGGGATATGTACCGGAAGGTTTATCACCACCCTGGGAAACATAATGCTGCCCCTTGGG
1761 CCCAGAAAGGGGTTTCCAGCTGGGGGCACGTGGACTGGTTCTGCTGTTTTTGGCAGTCGCTTTTCTGAATTCTCCCCTCC
1841 GGCAGCCTTCCAGAGACTGATCCTGGAGATTGAGTTGATTGTCTTGGCTAGACCTGTCATTTTAAGCTCTAGTCATAGCA
1921 CTTTTTCAGAGCATCTTAGGCACCATTGCAACCCAACCAGGGAAGCTGCATCCCTGTGGTGGTCCTTAGGCACCAGTCTT
2001 TGTTAAACAAAACCCTTTGGCACTATTGTGGTTTTCTATTCTCTGTCTGAACTCTATTCAAAAGTATCTTTGCTCTCTTG
2081 GGCCTTTTCTTTTACTGTTTTGTTTTTTTTTTTTCTAATCCTGCTTTCATACTAGCCAGTGTGGGGAAAAGGTACAATAT
2161 GTCAAAGAGATGAGAGAGTGTTATTTCTTGGGCAATTTTCTATTAGTGTTTCTTATTTTGGCCAGTTCTTTTATTTATGT
2241 CCTTGTGACCCAGGTACTTGGGGGGCCAGCTACCCTTCTGGCCTTTTAGCGTCTTTGAAGGAGACCAGACATGAGTGAAT
2321 ACCTAGGAGAGTGTCAGCATGTTTCTGGAAAATTGGCAGAGACCAAGCCCTGCTGCAGATTCGTCAGGCCAGGTGAAAGG
2401 GCCAGGCAGTTGCAGCTGATGATGTAAATATTTTGTACAGTAGATAAATAAATGTTTAAAAGAACTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugggagaCUUUCCUUCGu 5'
                 |::||||||| 
Target 5' ctaaggaGGGAGGAAGCt 3'
 1150 - 1167 147.00 -13.40
2 
miRNA  3' ugggagacuUUCCUUCGu 5'
                   |:|||||| 
Target 5' aacccaaccAGGGAAGCt 3'
 1950 - 1967 129.00 -14.40
3 
miRNA  3' ugggagacuuUCCUUCgu 5'
                    ||||||  
Target 5' atcagttatcAGGAAGga 3'
 1129 - 1146 120.00 -8.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26966517 50 COSMIC
COSN30110730 51 COSMIC
COSN30501344 56 COSMIC
COSN30514578 128 COSMIC
COSN20710475 144 COSMIC
COSN31543194 169 COSMIC
COSN28707270 188 COSMIC
COSN30544173 223 COSMIC
COSN31537951 246 COSMIC
COSN30176939 294 COSMIC
COSN31486315 631 COSMIC
COSN9617914 849 COSMIC
COSN28099494 1251 COSMIC
COSN21202653 1258 COSMIC
COSN21515711 1282 COSMIC
COSN20092859 1562 COSMIC
COSN31596374 1647 COSMIC
COSN17075860 1715 COSMIC
COSN31533370 1755 COSMIC
COSN28774789 1842 COSMIC
COSN9617913 2032 COSMIC
COSN21029527 2094 COSMIC
COSN20111479 2103 COSMIC
COSN8849885 2261 COSMIC
COSN23345901 2319 COSMIC
COSN31567673 2382 COSMIC
COSN30158053 2395 COSMIC
rs1045430 188 GWAS
rs16661 2107 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751662342 3 dbSNP
rs1462291307 5 dbSNP
rs764120730 13 dbSNP
rs763168136 17 dbSNP
rs1200912870 20 dbSNP
rs1404444657 26 dbSNP
rs1397971864 28 dbSNP
rs765007554 29 dbSNP
rs759342707 30 dbSNP
rs776480679 31 dbSNP
rs371335066 32 dbSNP
rs746900273 33 dbSNP
rs772849447 49 dbSNP
rs771646809 50 dbSNP
rs747808877 51 dbSNP
rs1300720448 62 dbSNP
rs946513097 63 dbSNP
rs75962251 64 dbSNP
rs1054770737 67 dbSNP
rs939007721 73 dbSNP
rs1292787763 74 dbSNP
rs1393536852 77 dbSNP
rs1490843815 80 dbSNP
rs901931562 95 dbSNP
rs1429088632 102 dbSNP
rs1329990714 108 dbSNP
rs928833019 111 dbSNP
rs760197143 112 dbSNP
rs886464792 113 dbSNP
rs981729711 114 dbSNP
rs1417317177 119 dbSNP
rs930905070 124 dbSNP
rs1384847200 125 dbSNP
rs543445945 130 dbSNP
rs1298414666 134 dbSNP
rs1339005072 145 dbSNP
rs916717530 149 dbSNP
rs752377833 152 dbSNP
rs578085826 157 dbSNP
rs1315976581 161 dbSNP
rs1361944528 166 dbSNP
rs766946503 168 dbSNP
rs1260267091 171 dbSNP
rs879186996 172 dbSNP
rs918786001 181 dbSNP
rs1376650029 182 dbSNP
rs1045430 188 dbSNP
rs1434456861 196 dbSNP
rs1184048252 202 dbSNP
rs962797052 205 dbSNP
rs1386678220 211 dbSNP
rs927690943 216 dbSNP
rs978268809 222 dbSNP
rs540838354 224 dbSNP
rs1018782502 234 dbSNP
rs1458137108 243 dbSNP
rs989378053 244 dbSNP
rs1259772664 246 dbSNP
rs1337846061 251 dbSNP
rs1006805789 257 dbSNP
rs113560779 259 dbSNP
rs1238179390 266 dbSNP
rs1306595143 286 dbSNP
rs1343148753 289 dbSNP
rs773706278 294 dbSNP
rs1241350959 307 dbSNP
rs114370888 309 dbSNP
rs765704156 310 dbSNP
rs997964271 312 dbSNP
rs999425102 317 dbSNP
rs1234223607 335 dbSNP
rs901040032 339 dbSNP
rs1250811479 340 dbSNP
rs1420337013 343 dbSNP
rs1173424984 350 dbSNP
rs1332976539 353 dbSNP
rs1469779829 354 dbSNP
rs1307138976 357 dbSNP
rs1446761714 363 dbSNP
rs1378239031 371 dbSNP
rs555261868 375 dbSNP
rs1408704772 387 dbSNP
rs902328950 391 dbSNP
rs1019012282 398 dbSNP
rs1297811465 401 dbSNP
rs762217236 409 dbSNP
rs1005397486 411 dbSNP
rs535766969 413 dbSNP
rs886414698 415 dbSNP
rs1322947020 417 dbSNP
rs148443518 419 dbSNP
rs1264936136 429 dbSNP
rs1172868317 432 dbSNP
rs556164952 434 dbSNP
rs1467230311 448 dbSNP
rs1011172178 450 dbSNP
rs1251524985 453 dbSNP
rs1481433641 454 dbSNP
rs1267491211 455 dbSNP
rs1157474366 456 dbSNP
rs1440269970 457 dbSNP
rs1239862990 468 dbSNP
rs1200693713 470 dbSNP
rs1385265966 473 dbSNP
rs1432162841 476 dbSNP
rs1464391825 480 dbSNP
rs77280012 485 dbSNP
rs1355318153 488 dbSNP
rs1054885037 490 dbSNP
rs145636056 491 dbSNP
rs1292035094 492 dbSNP
rs1055419450 497 dbSNP
rs1405645334 500 dbSNP
rs1441692818 501 dbSNP
rs1338422491 503 dbSNP
rs1256594062 506 dbSNP
rs927648584 507 dbSNP
rs939487079 509 dbSNP
rs1201286874 511 dbSNP
rs1290581126 512 dbSNP
rs928140880 517 dbSNP
rs1347370563 521 dbSNP
rs977839602 521 dbSNP
rs547473623 524 dbSNP
rs1474744005 526 dbSNP
rs930187887 527 dbSNP
rs918846743 528 dbSNP
rs989546601 534 dbSNP
rs375280557 539 dbSNP
rs747136919 546 dbSNP
rs747523844 552 dbSNP
rs1425373541 554 dbSNP
rs1305073805 557 dbSNP
rs17101802 559 dbSNP
rs1312169922 563 dbSNP
rs1446456900 565 dbSNP
rs1340286057 581 dbSNP
rs566305680 584 dbSNP
rs1363726257 588 dbSNP
rs757373688 591 dbSNP
rs1358187258 598 dbSNP
rs1313923381 604 dbSNP
rs549296165 618 dbSNP
rs529644190 623 dbSNP
rs377420528 625 dbSNP
rs950865923 630 dbSNP
rs192753900 631 dbSNP
rs144560323 632 dbSNP
rs1182201517 635 dbSNP
rs999503539 643 dbSNP
rs966626088 646 dbSNP
rs1022643276 652 dbSNP
rs1384807119 657 dbSNP
rs1445520949 665 dbSNP
rs1165725141 668 dbSNP
rs1405829448 674 dbSNP
rs1400193338 676 dbSNP
rs1318818109 677 dbSNP
rs1368886709 677 dbSNP
rs1346950576 679 dbSNP
rs1010701268 682 dbSNP
rs778960599 685 dbSNP
rs895012032 695 dbSNP
rs1033421533 703 dbSNP
rs1383291133 705 dbSNP
rs1003323992 710 dbSNP
rs777502460 716 dbSNP
rs895176902 725 dbSNP
rs906299426 728 dbSNP
rs11537957 758 dbSNP
rs1003810385 761 dbSNP
rs906667901 765 dbSNP
rs140608744 769 dbSNP
rs1319293848 776 dbSNP
rs189030078 777 dbSNP
rs897365498 780 dbSNP
rs777391393 783 dbSNP
rs1185578647 787 dbSNP
rs1231407359 798 dbSNP
rs1469678133 801 dbSNP
rs1039063101 802 dbSNP
rs1356198512 810 dbSNP
rs1410045079 821 dbSNP
rs1053494159 823 dbSNP
rs564258359 828 dbSNP
rs1454390745 832 dbSNP
rs1164205320 835 dbSNP
rs1326431098 836 dbSNP
rs1334875361 837 dbSNP
rs541095967 839 dbSNP
rs8016694 840 dbSNP
rs1364904720 858 dbSNP
rs1263063180 860 dbSNP
rs1324639836 875 dbSNP
rs1206028937 876 dbSNP
rs1271138415 878 dbSNP
rs1437515100 882 dbSNP
rs1182831672 885 dbSNP
rs976611600 888 dbSNP
rs1297265478 890 dbSNP
rs965683963 891 dbSNP
rs1198528297 896 dbSNP
rs908333039 902 dbSNP
rs985489587 903 dbSNP
rs1361948806 917 dbSNP
rs184914086 923 dbSNP
rs1395291018 926 dbSNP
rs767212604 930 dbSNP
rs1330511099 936 dbSNP
rs191500853 947 dbSNP
rs994945856 961 dbSNP
rs959331900 967 dbSNP
rs187535242 971 dbSNP
rs751120056 978 dbSNP
rs1422648024 980 dbSNP
rs1339177832 988 dbSNP
rs1196540014 1000 dbSNP
rs1022210215 1009 dbSNP
rs576332723 1013 dbSNP
rs959223499 1017 dbSNP
rs752434275 1019 dbSNP
rs765936922 1024 dbSNP
rs1221932307 1025 dbSNP
rs1033536294 1027 dbSNP
rs1003390962 1028 dbSNP
rs906246038 1038 dbSNP
rs893995231 1041 dbSNP
rs73301904 1049 dbSNP
rs762187508 1050 dbSNP
rs1169225581 1051 dbSNP
rs539426580 1052 dbSNP
rs898859726 1053 dbSNP
rs1423447348 1058 dbSNP
rs1303272259 1073 dbSNP
rs1366924997 1080 dbSNP
rs1388995289 1082 dbSNP
rs765140628 1083 dbSNP
rs1228687358 1084 dbSNP
rs777204298 1103 dbSNP
rs920897245 1107 dbSNP
rs1245312432 1109 dbSNP
rs764310654 1114 dbSNP
rs1490869586 1120 dbSNP
rs1203241047 1127 dbSNP
rs1260974923 1128 dbSNP
rs1447348242 1130 dbSNP
rs943759401 1134 dbSNP
rs761182486 1137 dbSNP
rs1341935132 1159 dbSNP
rs1195143503 1169 dbSNP
rs368190321 1176 dbSNP
rs759265509 1177 dbSNP
rs934170710 1179 dbSNP
rs1163865604 1190 dbSNP
rs1349942476 1191 dbSNP
rs1325519440 1202 dbSNP
rs922650950 1206 dbSNP
rs375303024 1212 dbSNP
rs1157325576 1214 dbSNP
rs1171060845 1230 dbSNP
rs945389830 1231 dbSNP
rs34442026 1241 dbSNP
rs915257316 1242 dbSNP
rs1381067541 1248 dbSNP
rs147148297 1265 dbSNP
rs1323517404 1270 dbSNP
rs776508866 1270 dbSNP
rs553782787 1276 dbSNP
rs533909512 1280 dbSNP
rs1421830430 1288 dbSNP
rs1033604684 1291 dbSNP
rs981901410 1292 dbSNP
rs1210334992 1295 dbSNP
rs1240998226 1302 dbSNP
rs959445709 1311 dbSNP
rs970587487 1322 dbSNP
rs1026059906 1329 dbSNP
rs531814859 1332 dbSNP
rs1416786946 1339 dbSNP
rs1456810697 1343 dbSNP
rs1363707153 1346 dbSNP
rs1257846019 1349 dbSNP
rs1454718905 1360 dbSNP
rs1162037372 1361 dbSNP
rs74959318 1364 dbSNP
rs1308901559 1372 dbSNP
rs529423446 1373 dbSNP
rs182865908 1376 dbSNP
rs1021604952 1380 dbSNP
rs1381702471 1388 dbSNP
rs1389711136 1399 dbSNP
rs893940160 1404 dbSNP
rs1016317775 1408 dbSNP
rs1007241623 1414 dbSNP
rs1376004619 1421 dbSNP
rs1322546609 1425 dbSNP
rs760049840 1427 dbSNP
rs3813557 1434 dbSNP
rs1040807059 1435 dbSNP
rs1448641838 1446 dbSNP
rs943690524 1450 dbSNP
rs1176292813 1452 dbSNP
rs1049970317 1460 dbSNP
rs1250565296 1461 dbSNP
rs1420354587 1462 dbSNP
rs1184888821 1465 dbSNP
rs752196911 1471 dbSNP
rs371025102 1472 dbSNP
rs901385282 1473 dbSNP
rs1357202898 1475 dbSNP
rs532198323 1481 dbSNP
rs1460612998 1483 dbSNP
rs192650656 1488 dbSNP
rs73301903 1490 dbSNP
rs1411809445 1497 dbSNP
rs915348449 1499 dbSNP
rs772461128 1503 dbSNP
rs80043099 1508 dbSNP
rs1223878037 1509 dbSNP
rs931253505 1510 dbSNP
rs760152663 1512 dbSNP
rs377550107 1513 dbSNP
rs919718807 1516 dbSNP
rs1203295969 1519 dbSNP
rs991316783 1524 dbSNP
rs1179671546 1528 dbSNP
rs1483740496 1529 dbSNP
rs926523701 1534 dbSNP
rs982057075 1535 dbSNP
rs1267342703 1536 dbSNP
rs1480424325 1538 dbSNP
rs1236053434 1539 dbSNP
rs1209046485 1545 dbSNP
rs1262722129 1562 dbSNP
rs1169993413 1563 dbSNP
rs188969970 1564 dbSNP
rs1431677338 1565 dbSNP
rs183738445 1567 dbSNP
rs971110027 1574 dbSNP
rs796078255 1577 dbSNP
rs191097372 1583 dbSNP
rs1020965120 1585 dbSNP
rs1405442149 1585 dbSNP
rs988766840 1586 dbSNP
rs1295835999 1594 dbSNP
rs1343906163 1597 dbSNP
rs771073965 1605 dbSNP
rs1045436 1606 dbSNP
rs1045437 1609 dbSNP
rs576114301 1611 dbSNP
rs562815954 1613 dbSNP
rs1490378895 1615 dbSNP
rs565083834 1616 dbSNP
rs545808632 1617 dbSNP
rs777778000 1622 dbSNP
rs1186340897 1627 dbSNP
rs1376757407 1634 dbSNP
rs900040800 1641 dbSNP
rs1016025809 1644 dbSNP
rs1302026563 1646 dbSNP
rs1007600034 1648 dbSNP
rs1384615528 1665 dbSNP
rs755846377 1679 dbSNP
rs1447608513 1684 dbSNP
rs1343427904 1702 dbSNP
rs577195551 1705 dbSNP
rs747978586 1715 dbSNP
rs540394312 1716 dbSNP
rs931010902 1721 dbSNP
rs1449962378 1730 dbSNP
rs528416084 1736 dbSNP
rs898406715 1744 dbSNP
rs1229602584 1755 dbSNP
rs1055748335 1768 dbSNP
rs901331476 1770 dbSNP
rs1042927210 1771 dbSNP
rs1466535709 1787 dbSNP
rs1181914037 1790 dbSNP
rs1159824167 1810 dbSNP
rs1421373227 1812 dbSNP
rs1473162497 1813 dbSNP
rs1183707366 1814 dbSNP
rs1405674190 1818 dbSNP
rs1009744925 1819 dbSNP
rs937137799 1820 dbSNP
rs533768069 1832 dbSNP
rs893843771 1836 dbSNP
rs1046887410 1839 dbSNP
rs574591728 1840 dbSNP
rs771619038 1841 dbSNP
rs1053913663 1844 dbSNP
rs937985255 1851 dbSNP
rs754576951 1852 dbSNP
rs185795264 1862 dbSNP
rs949506609 1867 dbSNP
rs913855945 1877 dbSNP
rs536064373 1883 dbSNP
rs1269340185 1884 dbSNP
rs926637702 1890 dbSNP
rs1046327464 1892 dbSNP
rs1331643959 1895 dbSNP
rs949257669 1898 dbSNP
rs1319808249 1899 dbSNP
rs988157711 1907 dbSNP
rs570125037 1909 dbSNP
rs958068072 1912 dbSNP
rs751244581 1914 dbSNP
rs941879832 1918 dbSNP
rs908954998 1921 dbSNP
rs550325029 1922 dbSNP
rs747891710 1931 dbSNP
rs115224556 1932 dbSNP
rs1414181076 1944 dbSNP
rs964157772 1945 dbSNP
rs1175503849 1948 dbSNP
rs866680573 1956 dbSNP
rs1415786354 1960 dbSNP
rs1326454615 1968 dbSNP
rs11537958 1984 dbSNP
rs1360035572 1985 dbSNP
rs776068006 1995 dbSNP
rs9441 1998 dbSNP
rs3813559 2004 dbSNP
rs995169702 2005 dbSNP
rs1222036852 2010 dbSNP
rs562221012 2014 dbSNP
rs1346188474 2020 dbSNP
rs556662428 2021 dbSNP
rs1010146153 2025 dbSNP
rs1271161542 2028 dbSNP
rs1437311908 2031 dbSNP
rs377428727 2038 dbSNP
rs1424814894 2039 dbSNP
rs1198647043 2054 dbSNP
rs906998236 2073 dbSNP
rs1191118300 2077 dbSNP
rs1165781794 2078 dbSNP
rs1032826317 2088 dbSNP
rs1429787093 2091 dbSNP
rs1309366636 2095 dbSNP
rs945912289 2096 dbSNP
rs1002310849 2101 dbSNP
rs548357349 2102 dbSNP
rs936658161 2103 dbSNP
rs16661 2107 dbSNP
rs925307131 2107 dbSNP
rs1229443457 2115 dbSNP
rs1268047614 2115 dbSNP
rs1341783338 2115 dbSNP
rs1357381046 2115 dbSNP
rs34192596 2115 dbSNP
rs796480740 2115 dbSNP
rs1453107686 2126 dbSNP
rs562577664 2128 dbSNP
rs964265101 2129 dbSNP
rs897699265 2131 dbSNP
rs1241131062 2132 dbSNP
rs74932001 2144 dbSNP
rs941853020 2151 dbSNP
rs1382781858 2157 dbSNP
rs1423466129 2171 dbSNP
rs1255892414 2181 dbSNP
rs1392132104 2184 dbSNP
rs1388867221 2197 dbSNP
rs909076444 2202 dbSNP
rs985825186 2208 dbSNP
rs150738091 2216 dbSNP
rs1300118442 2224 dbSNP
rs1380664286 2228 dbSNP
rs995272558 2229 dbSNP
rs761088391 2232 dbSNP
rs923038275 2239 dbSNP
rs190203219 2241 dbSNP
rs371594982 2242 dbSNP
rs1203336656 2250 dbSNP
rs1283242483 2258 dbSNP
rs535277229 2262 dbSNP
rs534107459 2266 dbSNP
rs1462400309 2271 dbSNP
rs1397210286 2272 dbSNP
rs1045578 2278 dbSNP
rs1034022667 2282 dbSNP
rs1464811357 2284 dbSNP
rs1021616762 2286 dbSNP
rs376937368 2290 dbSNP
rs554673196 2291 dbSNP
rs958426647 2310 dbSNP
rs1157348034 2330 dbSNP
rs1388294670 2332 dbSNP
rs1458152510 2335 dbSNP
rs1032485548 2337 dbSNP
rs1045621 2345 dbSNP
rs778627218 2355 dbSNP
rs1329905094 2356 dbSNP
rs1322804958 2364 dbSNP
rs1322246776 2368 dbSNP
rs576139637 2369 dbSNP
rs756478557 2370 dbSNP
rs1305811271 2371 dbSNP
rs1428769824 2382 dbSNP
rs746224272 2383 dbSNP
rs1174156174 2393 dbSNP
rs1476972886 2404 dbSNP
rs1260842870 2407 dbSNP
rs1046096484 2408 dbSNP
rs1377033586 2414 dbSNP
rs781490197 2421 dbSNP
rs1483433000 2425 dbSNP
rs1254148342 2428 dbSNP
rs1203280882 2433 dbSNP
rs1166916305 2438 dbSNP
rs1482873726 2439 dbSNP
rs1010059277 2443 dbSNP
rs1221312531 2444 dbSNP
rs905242940 2447 dbSNP
rs1274780183 2448 dbSNP
rs1052506492 2449 dbSNP
rs1182402059 2449 dbSNP
rs1239066495 2457 dbSNP
rs1411966125 2462 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000356357.4 | 3UTR | AUCAGGAAGGAGAACUAAGGAGGGAGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000356357.4 | 3UTR | UAAGGAGGGAGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
85 hsa-miR-516b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT077049 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT155261 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT446119 ASTN1 astrotactin 1 2 2
MIRT447355 STOM stomatin 2 2
MIRT469329 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT470201 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT475944 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT498268 KIAA1644 KIAA1644 2 2
MIRT501725 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT522860 KIAA1551 KIAA1551 2 2
MIRT527900 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT528557 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT531250 PDF peptide deformylase, mitochondrial 2 2
MIRT534410 SENP1 SUMO1/sentrin specific peptidase 1 2 2
MIRT544656 MED19 mediator complex subunit 19 2 2
MIRT550681 YARS tyrosyl-tRNA synthetase 2 2
MIRT557208 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 4
MIRT611532 DDB1 damage specific DNA binding protein 1 2 2
MIRT612087 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT616535 PARD6B par-6 family cell polarity regulator beta 2 4
MIRT616738 DCTN5 dynactin subunit 5 2 2
MIRT616754 SVOP SV2 related protein 2 4
MIRT617380 FAM227A family with sequence similarity 227 member A 2 2
MIRT617624 RAB3IP RAB3A interacting protein 2 2
MIRT620778 MT1A metallothionein 1A 2 2
MIRT623172 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT626034 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT627376 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT630533 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT631686 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT633896 FGF10 fibroblast growth factor 10 2 2
MIRT635933 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636275 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT636285 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT636502 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT638037 SHPK sedoheptulokinase 2 2
MIRT639162 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT639571 GORASP1 golgi reassembly stacking protein 1 2 2
MIRT641248 CENPN centromere protein N 2 2
MIRT643650 MYOCD myocardin 2 2
MIRT645490 TRIM63 tripartite motif containing 63 2 2
MIRT648016 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648102 LRRFIP1 LRR binding FLII interacting protein 1 2 2
MIRT648729 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT650177 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT652787 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT653248 SORD sorbitol dehydrogenase 2 2
MIRT654859 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT655533 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656390 MCU mitochondrial calcium uniporter 2 2
MIRT656881 KIF1C kinesin family member 1C 2 2
MIRT657083 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657629 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT658295 FAM83F family with sequence similarity 83 member F 2 2
MIRT659432 COL1A1 collagen type I alpha 1 chain 2 2
MIRT659791 CBLB Cbl proto-oncogene B 2 2
MIRT660153 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 2
MIRT660490 ARRDC3 arrestin domain containing 3 2 2
MIRT660503 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT666356 SIKE1 suppressor of IKBKE 1 2 2
MIRT677774 FKTN fukutin 2 2
MIRT688556 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT697415 ZFP91 ZFP91 zinc finger protein 2 2
MIRT709468 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT711154 WDR82P1 WD repeat domain 82 pseudogene 1 2 2
MIRT711467 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT712515 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT712661 PCTP phosphatidylcholine transfer protein 2 2
MIRT713304 TYRP1 tyrosinase related protein 1 2 2
MIRT714597 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT716603 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT717537 PYGO2 pygopus family PHD finger 2 2 2
MIRT718058 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT718539 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719768 ZNF236 zinc finger protein 236 2 2
MIRT720162 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT720360 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT721182 HOPX HOP homeobox 2 2
MIRT721278 RAD54L2 RAD54 like 2 2 2
MIRT721357 ENTHD1 ENTH domain containing 1 2 2
MIRT721504 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721918 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722278 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722789 FUT4 fucosyltransferase 4 2 2
MIRT724390 ABAT 4-aminobutyrate aminotransferase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-516b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-516b Bromocriptine approved 31101 Microarray Prolactinoma 22366961 2012 up-regulated
miR-516b Bromocriptine approved 31101 Quantitative real-time PCR Prolactinoma 22366961 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-516b-3p Paclitaxel 36314 NSC125973 approved sensitive High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-516b-3p Ribavirin+Pegylated IFNa-2b sensitive tissue (chronic hepatitis C)
hsa-miR-516b-3p Testosterone+Exemestane sensitive cell line (MCF-7)
hsa-miR-516b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-516b-3p Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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