pre-miRNA Information
pre-miRNA hsa-mir-103b-1   
Genomic Coordinates chr5: 168560904 - 168560965
Description Homo sapiens miR-103b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-103b-2   
Genomic Coordinates chr20: 3917502 - 3917563
Description Homo sapiens miR-103b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-103b
Sequence 1| UCAUAGCCCUGUACAAUGCUGCU |23
Evidence Experimental
Experiments ChIP-seq
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28198041 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369221403 4 dbSNP
rs1283132774 7 dbSNP
rs1222085747 10 dbSNP
rs572980521 14 dbSNP
rs748411363 15 dbSNP
rs769854452 23 dbSNP
Putative Targets

Gene Information
Gene Symbol CEP89   
Synonyms CCDC123, CEP123
Description centrosomal protein 89
Transcript NM_032816   
Expression
Putative miRNA Targets on CEP89
3'UTR of CEP89
(miRNA target sites are highlighted)
>CEP89|NM_032816|3'UTR
   1 AATCTGCGGGAGCCCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTGCAGGGCAGCCCAT
  81 GGTGGCAGCCGGAGGTGCGTAAGCCCACTGAACGCTGCAGGGCAGGGAAGAAATAAATGGTCTCATAGTTTAATCCATTG
 161 ATAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucGU-CGUAA--CAUGUC----CCGAUACu 5'
            || || ||   |:|||    | | ||| 
Target 5' caCAGGCCTTCCCTGCAGGGCAGCCCATGg 3'
53 - 82 89.00 -13.80
2
miRNA  3' ucgucGUAAC-----AUGUCCCGauacu 5'
               || ||     |:||||||     
Target 5' aagccCACTGAACGCTGCAGGGCaggga 3'
101 - 128 82.00 -14.10
3
miRNA  3' ucgucgUAACAUGUC--CCGAUACu 5'
                | | |:|:|  | | :|| 
Target 5' ------AATCTGCGGGAGCCCGTGg 3'
1 - 19 71.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26970470 7 COSMIC
COSN30106493 8 COSMIC
COSN15020634 15 COSMIC
COSN30468209 15 COSMIC
COSN31593638 17 COSMIC
COSN27107177 66 COSMIC
COSN17406984 93 COSMIC
COSN31596006 100 COSMIC
COSN31500087 101 COSMIC
COSN30506116 106 COSMIC
COSN31573543 130 COSMIC
COSN9849302 522 COSMIC
COSN9355037 603 COSMIC
COSN20723977 1112 COSMIC
COSN1766545 1317 COSMIC
COSN20979961 1386 COSMIC
COSN6142791 1424 COSMIC
COSN22425178 1707 COSMIC
COSN1214289 1747 COSMIC
COSN28895136 1868 COSMIC
COSN1766544 2134 COSMIC
COSN9849301 2761 COSMIC
COSN23751691 2809 COSMIC
COSN8259577 2934 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1411132150 3 dbSNP
rs757097133 4 dbSNP
rs199880123 7 dbSNP
rs763978785 8 dbSNP
rs762805067 12 dbSNP
rs1303919744 14 dbSNP
rs745439546 15 dbSNP
rs377001468 16 dbSNP
rs759191975 19 dbSNP
rs776078700 20 dbSNP
rs905516334 21 dbSNP
rs1482441009 24 dbSNP
rs770493510 26 dbSNP
rs532070824 31 dbSNP
rs1319226051 35 dbSNP
rs1289256370 38 dbSNP
rs1488138847 39 dbSNP
rs1191698444 43 dbSNP
rs1266358993 49 dbSNP
rs932411929 54 dbSNP
rs1427077692 59 dbSNP
rs1489187755 63 dbSNP
rs898208066 66 dbSNP
rs1037984252 67 dbSNP
rs1426532324 89 dbSNP
rs1263253819 90 dbSNP
rs559764233 91 dbSNP
rs1431205534 98 dbSNP
rs145640340 99 dbSNP
rs1348766457 105 dbSNP
rs1297320505 109 dbSNP
rs1311154733 113 dbSNP
rs1295813519 114 dbSNP
rs1360406449 116 dbSNP
rs1237742293 125 dbSNP
rs185168817 135 dbSNP
rs1326527877 137 dbSNP
rs895528489 142 dbSNP
rs939186806 144 dbSNP
rs1322392872 147 dbSNP
rs1223787484 148 dbSNP
rs1248389948 155 dbSNP
rs539347139 158 dbSNP
rs981301888 159 dbSNP
rs374849523 160 dbSNP
rs1454488386 166 dbSNP
rs1036932775 171 dbSNP
rs1248388791 172 dbSNP
rs1022332140 175 dbSNP
rs1365811483 176 dbSNP
rs1161281397 177 dbSNP
rs112767280 178 dbSNP
rs1439505868 180 dbSNP
rs956667498 180 dbSNP
rs2868196 183 dbSNP
rs943256453 183 dbSNP
rs2077201 184 dbSNP
rs1163191256 185 dbSNP
rs1367789358 185 dbSNP
rs879528551 185 dbSNP
rs954745519 187 dbSNP
rs1009116797 188 dbSNP
rs372397715 188 dbSNP
rs1196068235 189 dbSNP
rs777462289 190 dbSNP
rs1264638287 191 dbSNP
rs1268606444 191 dbSNP
rs1208776615 192 dbSNP
rs913962403 194 dbSNP
rs1287758171 195 dbSNP
rs1214123198 198 dbSNP
rs1183146067 200 dbSNP
rs1292829738 200 dbSNP
rs1472892594 200 dbSNP
rs71336972 200 dbSNP
rs1468571895 209 dbSNP
rs1333878099 218 dbSNP
rs551468954 225 dbSNP
rs1359990372 231 dbSNP
rs1352737614 234 dbSNP
rs1303985357 241 dbSNP
rs1235324910 242 dbSNP
rs1450442475 244 dbSNP
rs1029161353 246 dbSNP
rs988267004 247 dbSNP
rs997025489 255 dbSNP
rs1349950405 257 dbSNP
rs898239270 258 dbSNP
rs1288910708 259 dbSNP
rs1038058129 260 dbSNP
rs1198536636 262 dbSNP
rs1382884195 264 dbSNP
rs558794746 269 dbSNP
rs1211792655 273 dbSNP
rs886738372 294 dbSNP
rs1296605712 299 dbSNP
rs1230734109 305 dbSNP
rs539167942 326 dbSNP
rs1471985713 327 dbSNP
rs180690203 329 dbSNP
rs1414878622 338 dbSNP
rs939278759 352 dbSNP
rs1172413455 358 dbSNP
rs1426276246 359 dbSNP
rs1376447624 364 dbSNP
rs1002379645 366 dbSNP
rs969587575 377 dbSNP
rs1025245428 379 dbSNP
rs926471804 379 dbSNP
rs553436254 381 dbSNP
rs536611885 382 dbSNP
rs1377598145 385 dbSNP
rs568386642 389 dbSNP
rs1230932920 391 dbSNP
rs1197501166 397 dbSNP
rs895509531 405 dbSNP
rs1345437111 407 dbSNP
rs1220682367 408 dbSNP
rs1047936025 409 dbSNP
rs993295821 410 dbSNP
rs746641 413 dbSNP
rs946513887 421 dbSNP
rs915346196 422 dbSNP
rs943225196 440 dbSNP
rs567820338 443 dbSNP
rs910440161 444 dbSNP
rs1051713364 445 dbSNP
rs1202011801 454 dbSNP
rs988184679 455 dbSNP
rs11671966 457 dbSNP
rs1170605973 465 dbSNP
rs911889580 468 dbSNP
rs988169371 469 dbSNP
rs777499060 471 dbSNP
rs79874975 479 dbSNP
rs77976196 480 dbSNP
rs376396746 482 dbSNP
rs1438385544 495 dbSNP
rs969574821 496 dbSNP
rs1276465110 498 dbSNP
rs995030918 499 dbSNP
rs1399623374 506 dbSNP
rs1276241073 516 dbSNP
rs1013879123 517 dbSNP
rs963492790 530 dbSNP
rs959966890 533 dbSNP
rs1336525048 535 dbSNP
rs1025946141 538 dbSNP
rs35995416 542 dbSNP
rs576381543 544 dbSNP
rs1187118346 545 dbSNP
rs1016644433 554 dbSNP
rs1450395887 565 dbSNP
rs1190739136 566 dbSNP
rs190920792 576 dbSNP
rs886813307 577 dbSNP
rs898896524 586 dbSNP
rs1056113697 589 dbSNP
rs187342813 593 dbSNP
rs563370720 597 dbSNP
rs1391393710 602 dbSNP
rs781257847 603 dbSNP
rs117630116 607 dbSNP
rs1465633226 618 dbSNP
rs1045361632 628 dbSNP
rs753010231 629 dbSNP
rs1364191263 631 dbSNP
rs1435439567 643 dbSNP
rs1425148867 644 dbSNP
rs888972527 650 dbSNP
rs1338272708 652 dbSNP
rs533300718 658 dbSNP
rs1265489936 669 dbSNP
rs1359121971 674 dbSNP
rs766398935 675 dbSNP
rs1052555599 678 dbSNP
rs1237732092 683 dbSNP
rs1189308397 696 dbSNP
rs115760198 705 dbSNP
rs936671992 706 dbSNP
rs925347434 716 dbSNP
rs911906299 717 dbSNP
rs1423414804 719 dbSNP
rs1188395005 721 dbSNP
rs987477910 726 dbSNP
rs931948948 728 dbSNP
rs1387747809 731 dbSNP
rs181891385 736 dbSNP
rs974026715 738 dbSNP
rs386808721 739 dbSNP
rs561429892 741 dbSNP
rs1395056986 743 dbSNP
rs1256213264 745 dbSNP
rs55851701 746 dbSNP
rs536563145 747 dbSNP
rs1225977511 756 dbSNP
rs1330378140 760 dbSNP
rs982518480 761 dbSNP
rs951121167 762 dbSNP
rs565500778 767 dbSNP
rs1483071391 768 dbSNP
rs951623539 773 dbSNP
rs1258427320 775 dbSNP
rs764053952 777 dbSNP
rs1035153291 780 dbSNP
rs1003228697 785 dbSNP
rs142296375 786 dbSNP
rs963042211 787 dbSNP
rs1449638307 788 dbSNP
rs1398799759 789 dbSNP
rs1161066288 793 dbSNP
rs1375714433 798 dbSNP
rs1373987312 807 dbSNP
rs904817181 810 dbSNP
rs1328647780 818 dbSNP
rs190144010 822 dbSNP
rs765664282 824 dbSNP
rs893684277 829 dbSNP
rs573388717 835 dbSNP
rs1030128993 842 dbSNP
rs935432691 844 dbSNP
rs1230744930 848 dbSNP
rs1299727224 855 dbSNP
rs1311964114 860 dbSNP
rs890559972 864 dbSNP
rs1234351370 868 dbSNP
rs1471649915 872 dbSNP
rs1367672018 883 dbSNP
rs1257992065 890 dbSNP
rs1179082429 900 dbSNP
rs1459011437 904 dbSNP
rs1204582143 905 dbSNP
rs1252585045 909 dbSNP
rs573774619 910 dbSNP
rs1198034634 917 dbSNP
rs1265106006 917 dbSNP
rs932006054 937 dbSNP
rs1432389357 939 dbSNP
rs1468976648 961 dbSNP
rs536649815 962 dbSNP
rs1427399476 963 dbSNP
rs921917179 964 dbSNP
rs1226822393 980 dbSNP
rs777260989 981 dbSNP
rs892357225 987 dbSNP
rs1355987440 994 dbSNP
rs1292306736 995 dbSNP
rs1367439629 1007 dbSNP
rs764601958 1011 dbSNP
rs936639037 1014 dbSNP
rs1340350191 1016 dbSNP
rs531457567 1032 dbSNP
rs73041757 1040 dbSNP
rs1275512773 1042 dbSNP
rs376472164 1053 dbSNP
rs553979858 1067 dbSNP
rs1219376132 1074 dbSNP
rs1263642563 1075 dbSNP
rs908078120 1075 dbSNP
rs917997738 1075 dbSNP
rs1309195349 1077 dbSNP
rs1447356861 1080 dbSNP
rs1187527292 1086 dbSNP
rs557067656 1090 dbSNP
rs983596310 1097 dbSNP
rs1411165992 1104 dbSNP
rs112600495 1107 dbSNP
rs1349963842 1112 dbSNP
rs1458851054 1114 dbSNP
rs1328418716 1115 dbSNP
rs1363464952 1122 dbSNP
rs930150969 1127 dbSNP
rs1298628320 1128 dbSNP
rs1364289445 1130 dbSNP
rs1226714436 1131 dbSNP
rs1325027816 1136 dbSNP
rs569036248 1139 dbSNP
rs982234746 1140 dbSNP
rs969115951 1148 dbSNP
rs963012853 1149 dbSNP
rs1441337886 1151 dbSNP
rs1207815141 1153 dbSNP
rs1248280067 1155 dbSNP
rs112683198 1162 dbSNP
rs1179643274 1163 dbSNP
rs1177943467 1164 dbSNP
rs1478356018 1175 dbSNP
rs985764674 1180 dbSNP
rs1248517256 1181 dbSNP
rs139678953 1183 dbSNP
rs1451218906 1185 dbSNP
rs1287047033 1186 dbSNP
rs1219180379 1192 dbSNP
rs1324329815 1195 dbSNP
rs1351975012 1208 dbSNP
rs1030511606 1210 dbSNP
rs1387018577 1220 dbSNP
rs1235662346 1222 dbSNP
rs1370430549 1224 dbSNP
rs1321595281 1226 dbSNP
rs1276083677 1235 dbSNP
rs893715535 1242 dbSNP
rs1030895383 1247 dbSNP
rs1433716737 1249 dbSNP
rs999380375 1272 dbSNP
rs1283731486 1276 dbSNP
rs997329321 1278 dbSNP
rs1235141296 1287 dbSNP
rs566255724 1296 dbSNP
rs368028967 1297 dbSNP
rs546245095 1300 dbSNP
rs932053902 1313 dbSNP
rs529652883 1315 dbSNP
rs560981668 1321 dbSNP
rs903783103 1322 dbSNP
rs1045047959 1325 dbSNP
rs1483300292 1338 dbSNP
rs75533701 1339 dbSNP
rs747994863 1346 dbSNP
rs908151833 1352 dbSNP
rs1157891976 1354 dbSNP
rs1472534038 1354 dbSNP
rs1410602537 1356 dbSNP
rs1413047439 1358 dbSNP
rs1047927249 1360 dbSNP
rs1414951961 1361 dbSNP
rs896541118 1364 dbSNP
rs1427236758 1369 dbSNP
rs1056980565 1370 dbSNP
rs1392091268 1371 dbSNP
rs1306213292 1374 dbSNP
rs531268594 1386 dbSNP
rs1279995508 1387 dbSNP
rs758490467 1387 dbSNP
rs930140189 1387 dbSNP
rs1477751219 1389 dbSNP
rs938870937 1394 dbSNP
rs928788266 1396 dbSNP
rs1212452460 1397 dbSNP
rs918789410 1397 dbSNP
rs1248960973 1408 dbSNP
rs1483048922 1425 dbSNP
rs1183531569 1427 dbSNP
rs1264095215 1429 dbSNP
rs1038581034 1432 dbSNP
rs981923289 1440 dbSNP
rs565402453 1441 dbSNP
rs1426175427 1444 dbSNP
rs545636125 1456 dbSNP
rs1166842243 1462 dbSNP
rs1370009103 1468 dbSNP
rs1410444578 1468 dbSNP
rs985733584 1469 dbSNP
rs916278836 1480 dbSNP
rs989161069 1484 dbSNP
rs1434072909 1486 dbSNP
rs923030466 1488 dbSNP
rs1056636035 1491 dbSNP
rs956560937 1491 dbSNP
rs1271943211 1494 dbSNP
rs1340849441 1495 dbSNP
rs111468181 1497 dbSNP
rs1000703982 1503 dbSNP
rs1030927827 1506 dbSNP
rs73041755 1507 dbSNP
rs562524395 1508 dbSNP
rs186494215 1509 dbSNP
rs1012238117 1511 dbSNP
rs1389724993 1512 dbSNP
rs996303396 1518 dbSNP
rs1343680768 1530 dbSNP
rs1398600154 1534 dbSNP
rs1403514591 1544 dbSNP
rs777270638 1546 dbSNP
rs1056549532 1556 dbSNP
rs1442745797 1561 dbSNP
rs900595341 1575 dbSNP
rs754903342 1585 dbSNP
rs1363945374 1601 dbSNP
rs1338034835 1602 dbSNP
rs1006179751 1610 dbSNP
rs1354920203 1612 dbSNP
rs146373635 1617 dbSNP
rs1048000807 1619 dbSNP
rs1207165359 1622 dbSNP
rs1247680184 1623 dbSNP
rs1429307653 1624 dbSNP
rs941547987 1627 dbSNP
rs911444172 1631 dbSNP
rs202208156 1634 dbSNP
rs938930562 1637 dbSNP
rs931665603 1645 dbSNP
rs1395053709 1649 dbSNP
rs1159296338 1650 dbSNP
rs928843264 1653 dbSNP
rs1318249226 1659 dbSNP
rs1462836642 1659 dbSNP
rs1413909536 1660 dbSNP
rs535291926 1664 dbSNP
rs181328809 1665 dbSNP
rs948887191 1667 dbSNP
rs1338183788 1668 dbSNP
rs1364026762 1687 dbSNP
rs1243364509 1688 dbSNP
rs1476950304 1689 dbSNP
rs1262788696 1691 dbSNP
rs866820778 1694 dbSNP
rs142416938 1695 dbSNP
rs989192353 1696 dbSNP
rs957701832 1699 dbSNP
rs1267871184 1705 dbSNP
rs1486350024 1711 dbSNP
rs923597189 1711 dbSNP
rs79065831 1714 dbSNP
rs1254261210 1716 dbSNP
rs954773167 1733 dbSNP
rs1030217624 1735 dbSNP
rs1418524511 1737 dbSNP
rs1476128207 1739 dbSNP
rs996428877 1755 dbSNP
rs991182883 1757 dbSNP
rs1362993681 1759 dbSNP
rs960730869 1761 dbSNP
rs1319285845 1763 dbSNP
rs538453310 1771 dbSNP
rs1399554290 1774 dbSNP
rs11670695 1775 dbSNP
rs537196119 1777 dbSNP
rs1219982975 1779 dbSNP
rs375106557 1785 dbSNP
rs1315642205 1787 dbSNP
rs1006254783 1788 dbSNP
rs1357970125 1793 dbSNP
rs897219793 1812 dbSNP
rs886481391 1813 dbSNP
rs1047717540 1814 dbSNP
rs552742475 1824 dbSNP
rs1050004057 1827 dbSNP
rs1447181736 1829 dbSNP
rs1401005170 1830 dbSNP
rs1211735465 1833 dbSNP
rs934204817 1836 dbSNP
rs1486643807 1839 dbSNP
rs536394780 1847 dbSNP
rs1179916582 1864 dbSNP
rs901430338 1868 dbSNP
rs1040423027 1873 dbSNP
rs1003160093 1876 dbSNP
rs935025756 1879 dbSNP
rs923674010 1886 dbSNP
rs1464161073 1887 dbSNP
rs1423114201 1888 dbSNP
rs907455606 1889 dbSNP
rs758589896 1903 dbSNP
rs916450130 1910 dbSNP
rs750665427 1911 dbSNP
rs1412064638 1914 dbSNP
rs371206952 1917 dbSNP
rs893278082 1921 dbSNP
rs1181692701 1924 dbSNP
rs1393532063 1925 dbSNP
rs1458585699 1929 dbSNP
rs990675116 1931 dbSNP
rs1330791212 1937 dbSNP
rs550564516 1951 dbSNP
rs1034959509 1957 dbSNP
rs1340139034 1959 dbSNP
rs1204448099 1965 dbSNP
rs1053560023 1968 dbSNP
rs1250725380 1972 dbSNP
rs1199924669 1990 dbSNP
rs770834957 1991 dbSNP
rs936405591 1997 dbSNP
rs1264988130 2000 dbSNP
rs34035782 2002 dbSNP
rs1396450985 2003 dbSNP
rs757564234 2014 dbSNP
rs932963855 2017 dbSNP
rs1310281807 2023 dbSNP
rs1245023463 2024 dbSNP
rs1355665985 2035 dbSNP
rs1463957923 2037 dbSNP
rs1005628197 2038 dbSNP
rs1394197842 2039 dbSNP
rs1442007957 2044 dbSNP
rs1305912460 2069 dbSNP
rs1363244904 2072 dbSNP
rs77193470 2073 dbSNP
rs200252724 2086 dbSNP
rs117274342 2088 dbSNP
rs1016033625 2093 dbSNP
rs901393182 2094 dbSNP
rs566035594 2097 dbSNP
rs560034300 2104 dbSNP
rs1294254314 2105 dbSNP
rs934966966 2106 dbSNP
rs1459623060 2113 dbSNP
rs902221607 2116 dbSNP
rs1348401384 2119 dbSNP
rs1043486634 2130 dbSNP
rs950794824 2131 dbSNP
rs188562125 2133 dbSNP
rs1440725294 2134 dbSNP
rs1003286914 2136 dbSNP
rs907176083 2141 dbSNP
rs1023650768 2144 dbSNP
rs775914260 2145 dbSNP
rs1417697457 2152 dbSNP
rs1013152823 2153 dbSNP
rs893330381 2154 dbSNP
rs529424094 2155 dbSNP
rs934783885 2158 dbSNP
rs1430268588 2160 dbSNP
rs1289593101 2173 dbSNP
rs563598482 2176 dbSNP
rs902268641 2190 dbSNP
rs765885316 2191 dbSNP
rs762518144 2194 dbSNP
rs1274789852 2197 dbSNP
rs909853343 2213 dbSNP
rs1354156989 2214 dbSNP
rs1287979945 2217 dbSNP
rs1242267953 2220 dbSNP
rs1486568163 2223 dbSNP
rs1237853606 2225 dbSNP
rs1257485412 2246 dbSNP
rs984090257 2255 dbSNP
rs954105744 2263 dbSNP
rs1028420503 2273 dbSNP
rs370017033 2278 dbSNP
rs1302036969 2285 dbSNP
rs543821143 2287 dbSNP
rs965599323 2292 dbSNP
rs1302789815 2299 dbSNP
rs922950157 2308 dbSNP
rs1354794046 2312 dbSNP
rs1032338951 2313 dbSNP
rs1294971246 2324 dbSNP
rs999140531 2327 dbSNP
rs1222932933 2338 dbSNP
rs1284544921 2341 dbSNP
rs529168636 2355 dbSNP
rs1318303939 2361 dbSNP
rs975089539 2372 dbSNP
rs1256179745 2375 dbSNP
rs943287300 2404 dbSNP
rs1157287086 2410 dbSNP
rs1419603166 2415 dbSNP
rs1250175777 2429 dbSNP
rs1469969337 2433 dbSNP
rs1043371536 2434 dbSNP
rs1378757721 2443 dbSNP
rs1198903966 2444 dbSNP
rs1376138148 2452 dbSNP
rs183782886 2456 dbSNP
rs984595966 2461 dbSNP
rs772837977 2466 dbSNP
rs769380250 2467 dbSNP
rs1264747173 2476 dbSNP
rs1279900909 2477 dbSNP
rs981519030 2488 dbSNP
rs558440951 2490 dbSNP
rs971831006 2491 dbSNP
rs1022944750 2492 dbSNP
rs927856813 2494 dbSNP
rs1212344479 2496 dbSNP
rs1271544977 2503 dbSNP
rs1214234063 2513 dbSNP
rs1437728427 2526 dbSNP
rs376009179 2528 dbSNP
rs893402589 2552 dbSNP
rs1256543733 2555 dbSNP
rs939902950 2556 dbSNP
rs148788780 2560 dbSNP
rs999043935 2561 dbSNP
rs903322886 2569 dbSNP
rs954102932 2574 dbSNP
rs1394294427 2582 dbSNP
rs921332909 2589 dbSNP
rs1042560283 2605 dbSNP
rs1400820403 2606 dbSNP
rs1438373846 2610 dbSNP
rs1342664072 2611 dbSNP
rs976904536 2612 dbSNP
rs1235909409 2621 dbSNP
rs997257707 2627 dbSNP
rs144396401 2630 dbSNP
rs1339371408 2644 dbSNP
rs1038688992 2648 dbSNP
rs943004316 2649 dbSNP
rs909135458 2651 dbSNP
rs968933301 2652 dbSNP
rs1253898866 2656 dbSNP
rs1469964784 2660 dbSNP
rs1021895561 2665 dbSNP
rs1010562660 2683 dbSNP
rs1372576507 2684 dbSNP
rs894834277 2691 dbSNP
rs1003326968 2702 dbSNP
rs906278851 2707 dbSNP
rs1048941210 2712 dbSNP
rs552781373 2714 dbSNP
rs1442628677 2718 dbSNP
rs919082612 2723 dbSNP
rs1227448178 2730 dbSNP
rs1316387636 2734 dbSNP
rs909790923 2734 dbSNP
rs1333274054 2738 dbSNP
rs981954755 2762 dbSNP
rs1048324840 2765 dbSNP
rs932643228 2767 dbSNP
rs1337312130 2769 dbSNP
rs1203621484 2796 dbSNP
rs1261235082 2798 dbSNP
rs971501642 2799 dbSNP
rs1191182277 2800 dbSNP
rs1447682185 2811 dbSNP
rs915949557 2828 dbSNP
rs991492824 2833 dbSNP
rs1265298026 2834 dbSNP
rs11666472 2835 dbSNP
rs543639437 2847 dbSNP
rs111740430 2848 dbSNP
rs999096215 2849 dbSNP
rs1156458983 2850 dbSNP
rs1383728854 2854 dbSNP
rs1482267713 2861 dbSNP
rs977554777 2865 dbSNP
rs556732674 2868 dbSNP
rs537059813 2876 dbSNP
rs1354166037 2877 dbSNP
rs113211034 2896 dbSNP
rs746933477 2897 dbSNP
rs1021866174 2905 dbSNP
rs1357777636 2907 dbSNP
rs1237279072 2923 dbSNP
rs997707852 2935 dbSNP
rs771238725 2937 dbSNP
rs1276568600 2938 dbSNP
rs1351636007 2939 dbSNP
rs1227076638 2940 dbSNP
rs1341443609 2941 dbSNP
rs1134575 2954 dbSNP
rs1207024485 2965 dbSNP
rs901600473 2969 dbSNP
rs149550516 2970 dbSNP
rs551392047 2972 dbSNP
rs752720766 2975 dbSNP
rs887413260 2992 dbSNP
rs1048993900 2995 dbSNP
rs929218623 3006 dbSNP
rs765117730 3014 dbSNP
rs1179341192 3044 dbSNP
rs1362900249 3045 dbSNP
rs1003639840 3062 dbSNP
rs1406045449 3069 dbSNP
rs919120968 3076 dbSNP
rs1015326480 3078 dbSNP
rs369186922 3089 dbSNP
rs1390068827 3095 dbSNP
rs1306710257 3097 dbSNP
rs1465712889 3104 dbSNP
rs1336637810 3108 dbSNP
rs1241448323 3110 dbSNP
rs949886101 3114 dbSNP
rs916017785 3115 dbSNP
rs779922005 3121 dbSNP
rs1211625319 3134 dbSNP
rs528820748 3137 dbSNP
rs138342316 3141 dbSNP
rs1193904674 3147 dbSNP
rs1368812383 3158 dbSNP
rs745881224 3159 dbSNP
rs571962902 3160 dbSNP
rs565404224 3172 dbSNP
rs925926286 3174 dbSNP
rs553714723 3179 dbSNP
rs563687561 3195 dbSNP
rs1361460075 3198 dbSNP
rs1460907274 3199 dbSNP
rs1298034015 3203 dbSNP
rs1421950740 3214 dbSNP
rs74798671 3217 dbSNP
rs1393441172 3224 dbSNP
rs541389211 3235 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000305768.5 | 3UTR | UGAUCAUGCCACUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000305768.5 | 3UTR | UGAUCAUGCCACUGCACUCCAGCCUGGGCAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000305768.5 | 3UTR | AGUGAGCUAUGAUCAUGCCACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.475 9.5e-3 0.230 1.4e-1 24 Click to see details
GSE28260 Renal cortex and medulla 0.536 3.0e-2 0.615 1.3e-2 13 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-103b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT218386 E2F3 E2F transcription factor 3 2 2
MIRT404221 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT441502 SPG20 spartin 2 6
MIRT444124 ZNRF3 zinc and ring finger 3 2 2
MIRT454236 OSBPL10 oxysterol binding protein like 10 2 4
MIRT457919 ZNF212 zinc finger protein 212 2 2
MIRT462254 LAMA4 laminin subunit alpha 4 2 2
MIRT463176 ZNF281 zinc finger protein 281 2 2
MIRT472355 TSPAN1 tetraspanin 1 2 2
MIRT474133 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT494946 IFFO2 intermediate filament family orphan 2 2 2
MIRT497403 NPY4R neuropeptide Y receptor Y4 2 2
MIRT497641 GLDN gliomedin 2 2
MIRT505340 TMEM245 transmembrane protein 245 2 6
MIRT505680 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT510706 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT512198 C1orf43 chromosome 1 open reading frame 43 2 2
MIRT522089 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT525074 FRK fyn related Src family tyrosine kinase 2 2
MIRT531276 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT535119 PLXNA2 plexin A2 2 2
MIRT540836 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541018 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT545752 CA12 carbonic anhydrase 12 2 4
MIRT546404 SRP9 signal recognition particle 9 2 2
MIRT547991 HCFC2 host cell factor C2 2 4
MIRT554502 SAE1 SUMO1 activating enzyme subunit 1 2 2
MIRT558360 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT558863 CD2AP CD2 associated protein 2 2
MIRT559939 ZNF567 zinc finger protein 567 2 2
MIRT566300 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT567490 FOXK1 forkhead box K1 2 2
MIRT617139 ZNF556 zinc finger protein 556 2 2
MIRT625400 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT626491 CEP89 centrosomal protein 89 2 2
MIRT629487 GSN gelsolin 2 4
MIRT638456 PLXDC2 plexin domain containing 2 2 2
MIRT648498 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT654845 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT664587 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664977 TDRD1 tudor domain containing 1 2 2
MIRT665028 ELK1 ELK1, ETS transcription factor 2 2
MIRT666043 STON2 stonin 2 2 2
MIRT668863 CRY2 cryptochrome circadian clock 2 2 2
MIRT669297 C17orf85 nuclear cap binding subunit 3 2 2
MIRT680975 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682267 RS1 retinoschisin 1 2 2
MIRT685283 KIAA1143 KIAA1143 2 2
MIRT693375 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT701785 MSL1 male specific lethal 1 homolog 2 2
MIRT709373 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT715154 IL12B interleukin 12B 2 2
MIRT734499 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-103b Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-103b Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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