pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol RPLP1   
Synonyms LP1, P1, RPP1
Description ribosomal protein lateral stalk subunit P1
Transcript NM_001003   
Other Transcripts NM_213725   
Expression
Putative miRNA Targets on RPLP1
3'UTR of RPLP1
(miRNA target sites are highlighted)
>RPLP1|NM_001003|3'UTR
   1 ACCTCTTTTATAACATGTTCAATAAAAAGCTGAACTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28164786 4 COSMIC
COSN8590293 154 COSMIC
COSN6278962 212 COSMIC
COSN17590429 555 COSMIC
COSN15810711 611 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765659388 3 dbSNP
rs1248806530 4 dbSNP
rs201427547 6 dbSNP
rs1406462480 9 dbSNP
rs1451544124 9 dbSNP
rs1339816580 11 dbSNP
rs202225518 12 dbSNP
rs1332051978 15 dbSNP
rs760411129 19 dbSNP
rs548004580 21 dbSNP
rs753479085 22 dbSNP
rs1382445777 23 dbSNP
rs1337943012 24 dbSNP
rs891749437 26 dbSNP
rs761416059 34 dbSNP
rs1297328209 37 dbSNP
rs200720703 39 dbSNP
rs1326047288 40 dbSNP
rs1424172314 44 dbSNP
rs752174225 46 dbSNP
rs201563838 47 dbSNP
rs1381151634 52 dbSNP
rs1448146397 56 dbSNP
rs768035130 57 dbSNP
rs1471819991 59 dbSNP
rs752982175 62 dbSNP
rs1477541695 64 dbSNP
rs974630507 67 dbSNP
rs1327414287 70 dbSNP
rs1361465680 81 dbSNP
rs1028850976 86 dbSNP
rs1425948656 88 dbSNP
rs1453828595 95 dbSNP
rs1261542510 114 dbSNP
rs1050913476 116 dbSNP
rs1216338593 117 dbSNP
rs1488445891 121 dbSNP
rs1336409651 123 dbSNP
rs564613487 124 dbSNP
rs967890130 125 dbSNP
rs1354988982 128 dbSNP
rs1284727953 131 dbSNP
rs1246959634 136 dbSNP
rs1381055509 146 dbSNP
rs1230819825 154 dbSNP
rs139070897 155 dbSNP
rs547455572 159 dbSNP
rs923709615 160 dbSNP
rs1300203730 161 dbSNP
rs1403709572 170 dbSNP
rs1390045727 176 dbSNP
rs1163889494 178 dbSNP
rs1018048078 180 dbSNP
rs1280648523 181 dbSNP
rs570755023 189 dbSNP
rs1422091810 191 dbSNP
rs539130213 191 dbSNP
rs867697105 200 dbSNP
rs995197145 201 dbSNP
rs1025901530 202 dbSNP
rs951698043 204 dbSNP
rs1466112874 206 dbSNP
rs1188771591 228 dbSNP
rs1419493333 229 dbSNP
rs142400150 231 dbSNP
rs1257284307 232 dbSNP
rs1219020219 233 dbSNP
rs769295132 234 dbSNP
rs549904170 246 dbSNP
rs1474132857 250 dbSNP
rs1173887403 258 dbSNP
rs918052935 259 dbSNP
rs927481703 267 dbSNP
rs969979577 270 dbSNP
rs1470556152 271 dbSNP
rs1176360279 276 dbSNP
rs1404309163 278 dbSNP
rs1170541814 286 dbSNP
rs930819056 288 dbSNP
rs1437773090 309 dbSNP
rs1166765284 315 dbSNP
rs1171150073 317 dbSNP
rs1477532929 320 dbSNP
rs1200393512 325 dbSNP
rs772786408 326 dbSNP
rs1326142170 331 dbSNP
rs886527772 337 dbSNP
rs1428896933 341 dbSNP
rs925401468 345 dbSNP
rs1319884381 347 dbSNP
rs1276293294 359 dbSNP
rs1276635417 361 dbSNP
rs1324402257 370 dbSNP
rs1275591141 372 dbSNP
rs751112039 374 dbSNP
rs72758420 375 dbSNP
rs1330733068 376 dbSNP
rs1052419085 377 dbSNP
rs1448214955 380 dbSNP
rs913897189 387 dbSNP
rs560508781 389 dbSNP
rs945943191 390 dbSNP
rs1051471850 396 dbSNP
rs890932662 400 dbSNP
rs1209188901 402 dbSNP
rs1260605163 403 dbSNP
rs1444853726 415 dbSNP
rs1437304027 421 dbSNP
rs1200565376 425 dbSNP
rs996119955 427 dbSNP
rs1006756337 429 dbSNP
rs1235607551 431 dbSNP
rs529645880 431 dbSNP
rs1442746493 434 dbSNP
rs757950325 435 dbSNP
rs1039454801 436 dbSNP
rs1351740523 442 dbSNP
rs1308699465 443 dbSNP
rs1427872112 455 dbSNP
rs1240953286 468 dbSNP
rs1463912 490 dbSNP
rs554743133 507 dbSNP
rs185533009 508 dbSNP
rs1360062792 515 dbSNP
rs1336535413 516 dbSNP
rs1399131972 525 dbSNP
rs951124951 525 dbSNP
rs991845101 540 dbSNP
rs1325815624 543 dbSNP
rs1346197908 546 dbSNP
rs1404465815 548 dbSNP
rs1281286126 551 dbSNP
rs1352331585 552 dbSNP
rs1181161918 553 dbSNP
rs115934157 554 dbSNP
rs1217444193 555 dbSNP
rs1239024268 555 dbSNP
rs1285511587 555 dbSNP
rs1294306855 555 dbSNP
rs35544190 555 dbSNP
rs78250796 555 dbSNP
rs796442422 555 dbSNP
rs377136654 556 dbSNP
rs1025663594 557 dbSNP
rs969012516 562 dbSNP
rs1348305118 564 dbSNP
rs1211220285 566 dbSNP
rs767971809 574 dbSNP
rs969572428 578 dbSNP
rs1290191855 580 dbSNP
rs754792202 582 dbSNP
rs980354788 592 dbSNP
rs927565339 595 dbSNP
rs752955410 596 dbSNP
rs1298384556 601 dbSNP
rs190255732 602 dbSNP
rs925361319 603 dbSNP
rs1253353560 604 dbSNP
rs1473826529 605 dbSNP
rs1183198443 608 dbSNP
rs1363547875 613 dbSNP
rs930851384 613 dbSNP
rs1468963137 614 dbSNP
rs1415854960 616 dbSNP
rs577082958 619 dbSNP
rs1477336324 620 dbSNP
rs181510849 633 dbSNP
rs555768445 638 dbSNP
rs35605364 646 dbSNP
rs1424095067 650 dbSNP
rs988185097 652 dbSNP
rs913879598 655 dbSNP
rs1220925767 669 dbSNP
rs756389818 672 dbSNP
rs1372501191 675 dbSNP
rs764154932 677 dbSNP
rs1217216957 678 dbSNP
rs933329871 688 dbSNP
rs1391847037 690 dbSNP
rs986722200 694 dbSNP
rs753963296 699 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000260379.6 | 3UTR | AAGUGGAAAAAAAAAAAGAUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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